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Aliases for CAPN11 Gene

Aliases for CAPN11 Gene

  • Calpain 11 2 3 5
  • Calcium-Activated Neutral Proteinase 11 3 4
  • CANP 11 3 4
  • EC 63
  • EC 63
  • EC 3.4.22.- 4
  • Calpain11 3
  • EC 3.4.22 63

External Ids for CAPN11 Gene

Previous GeneCards Identifiers for CAPN11 Gene

  • GC06P044128
  • GC06P044173
  • GC06P044235
  • GC06P043847

Summaries for CAPN11 Gene

Entrez Gene Summary for CAPN11 Gene

  • Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis. [provided by RefSeq, Dec 2008]

GeneCards Summary for CAPN11 Gene

CAPN11 (Calpain 11) is a Protein Coding gene. Among its related pathways are DREAM Repression and Dynorphin Expression and Focal Adhesion. GO annotations related to this gene include calcium ion binding and calcium-dependent cysteine-type endopeptidase activity. An important paralog of this gene is CAPN9.

UniProtKB/Swiss-Prot for CAPN11 Gene

  • Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

Tocris Summary for CAPN11 Gene

  • Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPN11 Gene

Genomics for CAPN11 Gene

Regulatory Elements for CAPN11 Gene

Enhancers for CAPN11 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CAPN11 on UCSC Golden Path with GeneCards custom track

Genomic Location for CAPN11 Gene

44,158,811 bp from pter
44,184,402 bp from pter
25,592 bases
Plus strand

Genomic View for CAPN11 Gene

Genes around CAPN11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPN11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPN11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPN11 Gene

Proteins for CAPN11 Gene

  • Protein details for CAPN11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2RA64
    • Q5T3G1
    • Q8N4R5

    Protein attributes for CAPN11 Gene

    739 amino acids
    Molecular mass:
    84423 Da
    Quaternary structure:
    • Heterodimer of a large (catalytic) and a small (regulatory) subunit.
    • Sequence=AAH33733.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG36761.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB52137.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CAPN11 Gene

Proteomics data for CAPN11 Gene at MOPED

Selected DME Specific Peptides for CAPN11 Gene

Post-translational modifications for CAPN11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAPN11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CAPN11 Gene

Gene Families for CAPN11 Gene

Suggested Antigen Peptide Sequences for CAPN11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 calpain catalytic domain.
  • Belongs to the peptidase C2 family.
  • Contains 1 calpain catalytic domain.
  • Contains 2 EF-hand domains.
  • Belongs to the peptidase C2 family.
genes like me logo Genes that share domains with CAPN11: view

Function for CAPN11 Gene

Molecular function for CAPN11 Gene

GENATLAS Biochemistry:
calpain 11,large polypeptide 11,calcium dependent,neutral cysteine proteinase,papain superfamily expressed in the testis
UniProtKB/Swiss-Prot CatalyticActivity:
Broad endopeptidase specificity.
UniProtKB/Swiss-Prot Function:
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

Enzyme Numbers (IUBMB) for CAPN11 Gene

Gene Ontology (GO) - Molecular Function for CAPN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004198 calcium-dependent cysteine-type endopeptidase activity IEA --
genes like me logo Genes that share ontologies with CAPN11: view
genes like me logo Genes that share phenotypes with CAPN11: view

Animal Model Products

miRNA for CAPN11 Gene

miRTarBase miRNAs that target CAPN11

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CAPN11 Gene

Localization for CAPN11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPN11 Gene

Cytoplasmic vesicle, secretory vesicle, acrosome.

Subcellular locations from

Jensen Localization Image for CAPN11 Gene COMPARTMENTS Subcellular localization image for CAPN11 gene
Compartment Confidence
cytosol 3
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CAPN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with CAPN11: view

Pathways & Interactions for CAPN11 Gene

genes like me logo Genes that share pathways with CAPN11: view

Pathways by source for CAPN11 Gene

Interacting Proteins for CAPN11 Gene

Gene Ontology (GO) - Biological Process for CAPN11 Gene


No data available for SIGNOR curated interactions for CAPN11 Gene

Drugs & Compounds for CAPN11 Gene

(2) Drugs for CAPN11 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
MDL 28170 Pharma Calpain and cathepsin B inhibitor, selective, Potent, selective calpain and cathepsin B inhibitor 0

(4) Additional Compounds for CAPN11 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Acetyl-Calpastatin (184-210) (human)
MG 132
PD 150606

(5) Tocris Compounds for CAPN11 Gene

Compound Action Cas Number
Acetyl-Calpastatin (184-210) (human) Selective calpain inhibitor 123714-50-1
Calpeptin Calpain and cathepsin L inhibitor 117591-20-5
MDL 28170 Potent, selective calpain and cathepsin B inhibitor 88191-84-8
MG 132 Proteasome and calpain inhibitor. Inhibits NF-kappaB activation 133407-82-6
PD 150606 Cell permeable calpain inhibitor 179528-45-1
genes like me logo Genes that share compounds with CAPN11: view

Transcripts for CAPN11 Gene

Unigene Clusters for CAPN11 Gene

Calpain 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAPN11 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - -
SP2: -
SP3: - -
SP4: - -
SP5: -
SP7: -

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25

Relevant External Links for CAPN11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CAPN11 Gene

mRNA expression in normal human tissues for CAPN11 Gene

mRNA differential expression in normal tissues according to GTEx for CAPN11 Gene

This gene is overexpressed in Testis (x27.2).

Protein differential expression in normal tissues from HIPED for CAPN11 Gene

This gene is overexpressed in Liver (24.8), Spleen (12.7), Kidney (12.5), and Platelet (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CAPN11 Gene

SOURCE GeneReport for Unigene cluster for CAPN11 Gene Hs.225953

mRNA Expression by UniProt/SwissProt for CAPN11 Gene

Tissue specificity: Highest expression in testis.
genes like me logo Genes that share expression patterns with CAPN11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for CAPN11 Gene

Orthologs for CAPN11 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPN11 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CAPN11 35
  • 84.16 (n)
  • 80.11 (a)
CAPN11 36
  • 77 (a)
(Canis familiaris)
Mammalia CAPN11 35
  • 84 (n)
  • 78.49 (a)
CAPN11 36
  • 70 (a)
(Mus musculus)
Mammalia Capn11 35
  • 79.6 (n)
  • 74.19 (a)
Capn11 16
Capn11 36
  • 74 (a)
(Pan troglodytes)
Mammalia CAPN11 35
  • 98.83 (n)
  • 97.87 (a)
CAPN11 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Capn11 35
  • 79.2 (n)
  • 73.52 (a)
(Danio rerio)
Actinopterygii zgc:85932 36
  • 35 (a)
fruit fly
(Drosophila melanogaster)
Insecta CalpA 37
  • 47 (a)
CalpB 37
  • 41 (a)
CalpC 37
  • 29 (a)
CalpA 36
  • 36 (a)
CalpB 36
  • 31 (a)
(Caenorhabditis elegans)
Secernentea clp-3 37
  • 36 (a)
clp-6 37
  • 40 (a)
clp-7 37
  • 43 (a)
clp-1 36
  • 30 (a)
clp-3 36
  • 26 (a)
clp-4 36
  • 31 (a)
clp-6 36
  • 33 (a)
clp-7 36
  • 28 (a)
Species with no ortholog for CAPN11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CAPN11 Gene

Gene Tree for CAPN11 (if available)
Gene Tree for CAPN11 (if available)

Paralogs for CAPN11 Gene

Paralogs for CAPN11 Gene

(14) SIMAP similar genes for CAPN11 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CAPN11: view

Variants for CAPN11 Gene

Sequence variations from dbSNP and Humsavar for CAPN11 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs7761137 - 44,183,753(+) CTTGA(A/G)CCTGG intron-variant, nc-transcript-variant, reference, missense
rs6938938 - 44,173,351(+) AGGCC(A/G)TGGAG nc-transcript-variant, reference, missense
rs16871612 - 44,177,326(+) TGTGG(C/T)CTGCA intron-variant, nc-transcript-variant, reference, missense
rs34710081 - 44,180,084(+) ATATC(A/G)TTATT nc-transcript-variant, reference, missense
rs35527493 - 44,180,155(+) CACAG(A/C/G/T)GAGTC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CAPN11 Gene

Variant ID Type Subtype PubMed ID
nsv509132 CNV Insertion 20534489
esv2732004 CNV Deletion 23290073
esv2292197 CNV Deletion 18987734
esv2732005 CNV Deletion 23290073
esv2732007 CNV Deletion 23290073
esv2732008 CNV Deletion 23290073
esv2732009 CNV Deletion 23290073
dgv1050e201 CNV Deletion 23290073
nsv510028 CNV Loss 20534489
esv1646210 CNV Deletion 17803354
esv2732011 CNV Deletion 23290073
esv1158501 CNV Deletion 17803354

Variation tolerance for CAPN11 Gene

Residual Variation Intolerance Score: 85.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.36; 90.80% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CAPN11 Gene

Disorders for CAPN11 Gene

Relevant External Links for CAPN11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CAPN11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAPN11 Gene

Publications for CAPN11 Gene

  1. CAPN11: a calpain with high mRNA levels in testis and located on chromosome 6. (PMID: 10409436) Dear T.N. … Boehm T. (Genomics 1999) 2 3 4 23 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  4. Characterisation of capn1, capn2-like, capn3 and capn11 genes in Atlantic halibut (Hippoglossus hippoglossus L.): Transcriptional regulation across tissues and in skeletal muscle at distinct nutritional states. (PMID: 20093171) Macqueen D.J. … Johnston I.A. (Gene 2010) 23
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for CAPN11 Gene

Sources for CAPN11 Gene