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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CAPN11 Gene

protein-coding   GIFtS: 58
GCID: GC06P044126

Calpain 11

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Calpain 111 2     EC 3.4.22.-3
Calcium-Activated Neutral Proteinase 112 3     EC 3.4.228
CANP 112 3     EC 3.4.22.528
calpain-112     EC 3.4.22.548
calpain112     

External Ids:    HGNC: 14781   Entrez Gene: 111312   Ensembl: ENSG000001372257   OMIM: 6048225   UniProtKB: Q9UMQ63   

Export aliases for CAPN11 gene to outside databases

Previous GC identifers: GC06P044128 GC06P044173 GC06P044235 GC06P043847


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CAPN11 Gene:
Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in
this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein
appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role
in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis.
(provided by RefSeq, Dec 2008)

GeneCards Summary for CAPN11 Gene: 
CAPN11 (calpain 11) is a protein-coding gene. Diseases associated with CAPN11 include gastric cancer, and muscular dystrophy, and among its related super-pathways are nNOS Signaling in Skeletal Muscle and Integrin Pathway. GO annotations related to this gene include calcium-dependent cysteine-type endopeptidase activity and calcium ion binding. An important paralog of this gene is CAPN6.

UniProtKB/Swiss-Prot: CAN11_HUMAN, Q9UMQ6
Function: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates
involved in cytoskeletal remodeling and signal transduction

summary for CAPN11 Gene:
Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals.
This family contains 14 members with mu-calpain (calpain 1) and m-calpain (calpain 2) being the most
well-characterized. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa
regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure. Calpains are regulated
by Ca2+ concentration, phosphorylation, calpastatin and probably by altering their subcellular localization
(limiting access to substrate). These endopeptidases have numerous functions including, but not limited to,
remodeling of cytoskeletal attachments to the plasma membrane during cell fusion and cell motility,
proteolytic modification of molecules in signal transduction pathways, degradation of enzymes controlling
progression through the cell cycle, regulation of gene expression, substrate degradation in some apoptotic
pathways, and an involvement in long-term potentiation. Perturbations in calpain activity have been
associated in pathophysiological processes contributing to type II diabetes (calpain 10), Alzheimer's
disease (calpain 1), gastric cancer (calpain 9) and muscular dystrophy (calpain 3).




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CAPN11 gene promoter:
         COUP-TF1   Max1   COUP   LCR-F1   POU3F2   MZF-1   POU2F1   COUP-TF   POU2F1a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCAPN11 promoter sequence
   Search SABiosciences Chromatin IP Primers for CAPN11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAPN11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p12

CAPN11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAPN11 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P044126:  view genomic region     (about GC identifiers)

Start:
44,126,548 bp from pter      End:
44,152,139 bp from pter
Size:
25,592 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CAN11_HUMAN, Q9UMQ6 (See protein sequence)
Recommended Name: Calpain-11  
Size: 739 amino acids; 84423 Da
Subunit: Heterodimer of a large (catalytic) and a small (regulatory) subunit
Subcellular location: Cytoplasmic vesicle, secretory vesicle, acrosome (By similarity)
Sequence caution: Sequence=AAH33733.1; Type=Erroneous initiation; Sequence=BAG36761.1; Type=Erroneous initiation;
Sequence=CAB52137.1; Type=Erroneous initiation;
Secondary accessions: B2RA64 Q5T3G1 Q8N4R5

Explore the universe of human proteins at neXtProt for CAPN11: NX_Q9UMQ6

Explore proteomics data for CAPN11 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UMQ6

  • 4/11 DME Specific Peptides for CAPN11 (Q9UMQ6) (see all 11)
     YAGIFHF  PSTFEPH  KLVFVHS  YEALSGG 

    CAPN11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CAPN11 Protein Expression
    REFSEQ proteins: NP_008989.2  
    ENSEMBL proteins: 
     ENSP00000432420   ENSP00000381758   ENSP00000431963   ENSP00000441078  

    Human Recombinant Protein Products for CAPN11: 
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    Novus Biologicals CAPN11 Proteins
    Novus Biologicals CAPN11 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CAPN11 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005622intracellular ----

    CAPN11 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for CAPN11


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    EFHAND: EF-hand domain containing

    5/8 InterPro protein domains (see all 8):
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom
     IPR001300 Peptidase_C2_calpain_cat
     IPR018247 EF_Hand_1_Ca_BS
     IPR000169 Pept_cys_AS

    Graphical View of Domain Structure for InterPro Entry Q9UMQ6

    ProtoNet protein and cluster: Q9UMQ6

    1 Blocks protein domain: IPB001300 Calpain cysteine protease (C2) family signature

    UniProtKB/Swiss-Prot: CAN11_HUMAN, Q9UMQ6
    Similarity: Belongs to the peptidase C2 family
    Similarity: Contains 1 calpain catalytic domain
    Similarity: Contains 2 EF-hand domains


    CAPN11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAN11_HUMAN, Q9UMQ6
    Function: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates
    involved in cytoskeletal remodeling and signal transduction
    Catalytic activity: Broad endopeptidase specificity

         Genatlas biochemistry entry for CAPN11:
    calpain 11,large polypeptide 11,calcium dependent,neutral cysteine proteinase,papain superfamily expressed in the
    testis

         Enzyme Numbers (IUBMB): EC 3.4.22.542 EC 3.4.222 EC 3.4.22.522 EC 3.4.22.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004198calcium-dependent cysteine-type endopeptidase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0008233peptidase activity TAS10409436
         
    CAPN11 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CAPN11 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CAPN11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAPN11 
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    miRNA
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    hsa-miR-922
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPN11


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CAPN11 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1DREAM Repression and Dynorphin Expression
    nNOS Signaling in Skeletal Muscle0.37
    Calpain Protease Regulates Cellular Mechanics0.31
    Caspase Cascade0.36
    2Integrin Pathway
    FAK1 Signaling0.67
    3Rho Family GTPases
    ERK Signaling0.61
    4Apoptosis Pathway
    Apoptosis Pathway0.45
    5Focal Adhesion
    Integrin-mediated cell adhesion0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CAPN11
        Caspase Cascade
    ERK Signaling
    Calpain Protease Regulates Cellular Mechanics
    FAK1 Signaling
    nNOS Signaling in Skeletal Muscle

    1 Tocris Bioscience Pathway for CAPN11
        Apoptosis Pathway

    1 BioSystems Pathway for CAPN11
        Integrin-mediated cell adhesion


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CAPN11

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for CAPN11 (ENSP000003817584) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANAPC11ENSP000003499574STRING: ENSP00000349957
    PRKAR1AENSP000003514104STRING: ENSP00000351410
    UNGENSP000002425764STRING: ENSP00000242576
    XRCC6ENSP000003522574STRING: ENSP00000352257
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--

    CAPN11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for CAPN11:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CAPN11 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Acetyl-Calpastatin (184-210) (human)Selective calpain inhibitor[123714-50-1]
    MDL 28170 Potent, selective calpain and cathepsin B inhibitor [88191-84-8]
    PD 150606Cell permeable calpain inhibitor[179528-45-1]
    MG 132Proteasome and calpain inhibitor. Inhibits NF-kappaB activation[133407-82-6]
    MG 101Calpain inhibitor; activates p53-dependent apoptosis[110044-82-1]

    1 HMDB Compound for CAPN11    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Search CenterWatch for drugs/clinical trials and news about CAPN11 / CAN11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CAPN11 gene: 
    NM_007058.3  

    Unigene Cluster for CAPN11:

    Calpain 11
    Hs.225953  [show with all ESTs]
    Unigene Representative Sequence: BC033733
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000532171 ENST00000398776(uc003owt.1 uc011dvn.2) ENST00000526118
    ENST00000524554 ENST00000533604 ENST00000542245

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate CAPN11:
    hsa-miR-922
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    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAPN11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPN11
    Sirion Biotech Customized lentivirus for stable overexpression of CAPN11 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAPN11
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAPN11

    Additional mRNA sequence: 

    AJ242832.1 AK300107.1 AK314054.1 BC033733.1 

    4 DOTS entries:

    DT.92032960  DT.121312846  DT.121312873  DT.121312848 

    15 AceView cDNA sequences:

    BX280178 BQ925378 BI825216 BI828421 BP371443 BM554389 BX345175 AJ242832 
    NM_007058 BG721593 BC033733 CD243920 BI460638 BI850928 BI559807 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CAPN11 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
    SP1:                          -                                                                       -                       -                                 
    SP2:              -                                                                                                                                             
    SP3:              -           -                                                                                                                                 
    SP4:              -           -                                                                                                                                 
    SP5:                          -                                                                                                                                 

    ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for CAPN11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CAPN11 expression in normal human tissues (normalized intensities)      CAPN11 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTGCTGTCC
    CAPN11 Expression
    About this image


    CAPN11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Endothelium (Cardiovascular System)
             PureStem endothelial progenitor 30-MV2-12
     
     Blood (Hematopoietic System)
             PureStem endothelial progenitor 30-MV2-12
     
     Testis (Reproductive System)

    See CAPN11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CAPN11

    SOURCE GeneReport for Unigene cluster: Hs.225953

    UniProtKB/Swiss-Prot: CAN11_HUMAN, Q9UMQ6
    Tissue specificity: Highest expression in testis

        SABiosciences Custom PCR Arrays for CAPN11
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAPN11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPN11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CAPN11 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Capn111 , 5 calpain 111, 5 79.89(n)1
    74.5(a)1
      17 (22.59 cM)5
    2689581  NM_001013767.21  NP_001013789.11 
     456302045 
    chicken
    (Gallus gallus)
    Aves CAPN16
    Calpain-1 catalytic subunit
    57(a)
    1 ↔ 1
    3(29680438-29690820)
    lizard
    (Anolis carolinensis)
    Reptilia CAPN116
    calpain 11
    60(a)
    1 ↔ 1
    1(227547842-227602381)
    zebrafish
    (Danio rerio)
    Actinopterygii capn1a6
    CAPN11 (2 of 2)6
    calpain 11
    58(a)
    55(a)
    1 ↔ many
    1 ↔ many
    13(43334374-43377626)
    22(26890263-26915140)
    fruit fly
    (Drosophila melanogaster)
    Insecta CalpA3 actin cytoskeleton organization and
    biogenesis more
    47(a)
    (best of 3)
      56D5   --
    worm
    (Caenorhabditis elegans)
    Secernentea clp-73   -- 43(a)
    (best of 3)
      IV(1435632-1445971)   --


    ENSEMBL Gene Tree for CAPN11 (if available)
    TreeFam Gene Tree for CAPN11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CAPN11 gene
    CAPN62  CAPN82  CAPN142  CAPNS12  CAPN132  CAPN12  CAPN52  CAPN92  
    CAPN32  CAPNS22  CAPN22  CAPN122  CAPN102  
    14 SIMAP similar genes for CAPN11 using alignment to 4 protein entries:     CAN11_HUMAN (see all proteins):
    CAPN2    CAPN1    CAPN8    CAPNS1    CAPNS2    CAPN9
    CAPN3    CAPN12    CAPN14    GCA    CAPN5    SRI
    CAPN13    CAPN6

    CAPN11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/825 SNPs in CAPN11 are shown (see all 825)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs763114541,2
    F--44124663(+) GCCTGT/ATTTCC 1 -- us2k11Minor allele frequency- A:0.09WA 118
    rs1906522041,2
    --44124766(+) TTAGCC/TGAGAC 1 -- us2k10--------
    rs1153424451,2
    C,F--44124948(+) ACACCC/TGTGCC 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs93949871,2
    C,F,A,H--44124954(+) GTGCCT/CGCCTG 1 -- us2k17Minor allele frequency- C:0.42WA NA CSA EA 366
    rs1162953221,2
    C,F--44124964(+) GCACCC/TTACCC 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs77537071,2
    C,H--44125104(+) TGGGGG/TCAGCA 1 -- us2k14Minor allele frequency- T:0.00NS EA 410
    rs1169833871,2
    F--44125117(+) AGATAC/GGGATA 1 -- us2k11Minor allele frequency- G:0.01EA 120
    rs1379728711,2
    --44125140(+) ATGGCC/TGGGCA 1 -- us2k10--------
    rs1135108681,2
    C,F--44125143(+) GCCGGG/ACACGG 1 -- us2k12Minor allele frequency- A:0.17CSA WA 120
    rs1435436711,2
    --44125172(+) CTAGCA/GCTTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CAPN11 (44126548 - 44152139 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for CAPN11 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2292197CNV Deletion18987734
    esv2732009CNV Deletion23290073
    esv1646210CNV Deletion17803354
    esv2732004CNV Deletion23290073
    dgv1050e201CNV Deletion23290073
    esv2732011CNV Deletion23290073
    esv2732007CNV Deletion23290073
    esv2732005CNV Deletion23290073
    esv1158501CNV Deletion17803354
    esv2732008CNV Deletion23290073

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604822    OMIM disorders: --

    3 diseases for CAPN11:    About MalaCards
    gastric cancer    muscular dystrophy    alzheimer's disease


    CAPN11 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for CAPN11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CAPN11 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with CAPN11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CAPN11: a calpain with high mRNA levels in testis and located on chromosome 6. (PubMed id 10409436)1, 2, 3, 9 Dear T.N.... Boehm T. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    4. Calpain 11 is unique to mouse spermatogenic cells. (PubMed id 16541461)1 Ben-Aharon I....Eddy E.M. (2006)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Calpain-calpastatin: a novel, complete calcium-dependent protease system in human spermatozoa. (PubMed id 10340998)1 Rojas F.J....Moretti-Rojas I. (1999)
    10. Calpain: new perspectives in molecular diversity and physiological-pathological involvement. (PubMed id 8070630)1 Saido T.C....Suzuki K. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11131 HGNC: 1478 AceView: CAPN11 Ensembl:ENSG00000137225 euGenes: HUgn11131
    ECgene: CAPN11 H-InvDB: CAPN11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CAPN11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CAPN11 gene:
    Search GeneIP for patents involving CAPN11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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