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Aliases for CAPN11 Gene

Aliases for CAPN11 Gene

  • Calpain 11 2 3
  • Calcium-Activated Neutral Proteinase 11 3 4
  • CANP 11 3 4
  • EC 3.4.22.54 63
  • EC 3.4.22.52 63
  • EC 3.4.22.- 4
  • Calpain-11 3
  • Calpain11 3
  • EC 3.4.22 63

External Ids for CAPN11 Gene

Previous GeneCards Identifiers for CAPN11 Gene

  • GC06P044128
  • GC06P044173
  • GC06P044235
  • GC06P043847

Summaries for CAPN11 Gene

Entrez Gene Summary for CAPN11 Gene

  • Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis. [provided by RefSeq, Dec 2008]

GeneCards Summary for CAPN11 Gene

CAPN11 (Calpain 11) is a Protein Coding gene. Among its related pathways are ERK Signaling and Apoptosis Pathway. GO annotations related to this gene include calcium ion binding and calcium-dependent cysteine-type endopeptidase activity. An important paralog of this gene is CAPN9.

UniProtKB/Swiss-Prot for CAPN11 Gene

  • Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction

Tocris Summary for CAPN11 Gene

  • Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. This family contains 14 members with mu-calpain (calpain 1) and m-calpain (calpain 2) being the most well-characterized. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure. Calpains are regulated by Ca2+ concentration, phosphorylation, calpastatin and probably by altering their subcellular localization (limiting access to substrate). These endopeptidases have numerous functions including, but not limited to, remodeling of cytoskeletal attachments to the plasma membrane during cell fusion and cell motility, proteolytic modification of molecules in signal transduction pathways, degradation of enzymes controlling progression through the cell cycle, regulation of gene expression, substrate degradation in some apoptotic pathways, and an involvement in long-term potentiation. Perturbations in calpain activity have been associated in pathophysiological processes contributing to type II diabetes (calpain 10), Alzheimer's disease (calpain 1), gastric cancer (calpain 9) and muscular dystrophy (calpain 3).

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPN11 Gene

Genomics for CAPN11 Gene

Regulatory Elements for CAPN11 Gene

Genomic Location for CAPN11 Gene

Start:
44,158,811 bp from pter
End:
44,184,402 bp from pter
Size:
25,592 bases
Orientation:
Plus strand

Genomic View for CAPN11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAPN11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPN11 Gene

Proteins for CAPN11 Gene

  • Protein details for CAPN11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UMQ6-CAN11_HUMAN
    Recommended name:
    Calpain-11
    Protein Accession:
    Q9UMQ6
    Secondary Accessions:
    • B2RA64
    • Q5T3G1
    • Q8N4R5

    Protein attributes for CAPN11 Gene

    Size:
    739 amino acids
    Molecular mass:
    84423 Da
    Quaternary structure:
    • Heterodimer of a large (catalytic) and a small (regulatory) subunit
    SequenceCaution:
    • Sequence=AAH33733.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG36761.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB52137.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CAPN11 Gene

Proteomics data for CAPN11 Gene at MOPED

Selected DME Specific Peptides for CAPN11 Gene

Post-translational modifications for CAPN11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAPN11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains for CAPN11 Gene

Gene Families for CAPN11 Gene

HGNC:
  • EFHAND :EF-hand domain containing

Suggested Antigen Peptide Sequences for CAPN11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UMQ6

UniProtKB/Swiss-Prot:

CAN11_HUMAN :
  • Q9UMQ6
Domain:
  • Contains 1 calpain catalytic domain.
  • Contains 2 EF-hand domains.
Family:
  • Belongs to the peptidase C2 family.
genes like me logo Genes that share domains with CAPN11: view

Function for CAPN11 Gene

Molecular function for CAPN11 Gene

GENATLAS Biochemistry: calpain 11,large polypeptide 11,calcium dependent,neutral cysteine proteinase,papain superfamily expressed in the testis
UniProtKB/Swiss-Prot CatalyticActivity: Broad endopeptidase specificity
UniProtKB/Swiss-Prot Function: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction

Enzyme Numbers (IUBMB) for CAPN11 Gene

Gene Ontology (GO) - Molecular Function for CAPN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA --
GO:0005509 calcium ion binding IEA --
GO:0008233 peptidase activity TAS 10409436
genes like me logo Genes that share ontologies with CAPN11: view

Animal Model Products

CRISPR Products

miRNA for CAPN11 Gene

miRTarBase miRNAs that target CAPN11

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CAPN11 Gene

Localization for CAPN11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPN11 Gene

Cytoplasmic vesicle, secretory vesicle, acrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAPN11 Gene COMPARTMENTS Subcellular localization image for CAPN11 gene
Compartment Confidence
cytosol 3
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CAPN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005622 intracellular --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with CAPN11: view

Pathways for CAPN11 Gene

genes like me logo Genes that share pathways with CAPN11: view

Pathways by source for CAPN11 Gene

1 Tocris pathway for CAPN11 Gene

Interacting Proteins for CAPN11 Gene

Gene Ontology (GO) - Biological Process for CAPN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IBA --
genes like me logo Genes that share ontologies with CAPN11: view

Compounds for CAPN11 Gene

(4) Tocris Compounds for CAPN11 Gene

Compound Action Cas Number
MDL 28170 Potent, selective calpain and cathepsin B inhibitor [88191-84-8]
MG 101 Calpain inhibitor; activates p53-dependent apoptosis [110044-82-1]
MG 132 Proteasome and calpain inhibitor. Inhibits NF-kappaB activation [133407-82-6]
PD 150606 Cell permeable calpain inhibitor [179528-45-1]

(1) HMDB Compounds for CAPN11 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with CAPN11: view

Transcripts for CAPN11 Gene

mRNA/cDNA for CAPN11 Gene

Unigene Clusters for CAPN11 Gene

Calpain 11:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAPN11

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CAPN11

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAPN11 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - -
SP2: -
SP3: - -
SP4: - -
SP5: -
SP6:
SP7: -

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for CAPN11 Gene

GeneLoc Exon Structure for
CAPN11
ECgene alternative splicing isoforms for
CAPN11

Expression for CAPN11 Gene

mRNA expression in normal human tissues for CAPN11 Gene

mRNA differential expression in normal tissues according to GTEx for CAPN11 Gene

This gene is overexpressed in Testis (27.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CAPN11 Gene

SOURCE GeneReport for Unigene cluster for CAPN11 Gene Hs.225953

mRNA Expression by UniProt/SwissProt for CAPN11 Gene

Q9UMQ6-CAN11_HUMAN
Tissue specificity: Highest expression in testis.
genes like me logo Genes that share expressions with CAPN11: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CAPN11 Gene

Orthologs for CAPN11 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPN11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAPN11 35
  • 98.83 (n)
  • 97.87 (a)
CAPN11 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CAPN11 35
  • 84.16 (n)
  • 80.11 (a)
CAPN11 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAPN11 35
  • 84 (n)
  • 78.49 (a)
CAPN11 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Capn11 35
  • 79.6 (n)
  • 74.19 (a)
Capn11 16
Capn11 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Capn11 35
  • 79.2 (n)
  • 73.52 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:85932 36
  • 35 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CalpA 36
  • 36 (a)
ManyToMany
CalpB 36
  • 31 (a)
ManyToMany
CalpA 37
  • 47 (a)
CalpB 37
  • 41 (a)
CalpC 37
  • 29 (a)
worm
(Caenorhabditis elegans)
Secernentea clp-1 36
  • 30 (a)
ManyToMany
clp-3 36
  • 26 (a)
ManyToMany
clp-4 36
  • 31 (a)
ManyToMany
clp-6 36
  • 33 (a)
ManyToMany
clp-7 36
  • 28 (a)
ManyToMany
clp-7 37
  • 43 (a)
clp-6 37
  • 40 (a)
clp-3 37
  • 36 (a)
Species with no ortholog for CAPN11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CAPN11 Gene

ENSEMBL:
Gene Tree for CAPN11 (if available)
TreeFam:
Gene Tree for CAPN11 (if available)

Paralogs for CAPN11 Gene

Selected SIMAP similar genes for CAPN11 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CAPN11: view

Variants for CAPN11 Gene

Sequence variations from dbSNP and Humsavar for CAPN11 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs885130 -- 44,157,905(+) TTAAT(A/T)TTCTC upstream-variant-2KB
rs914501 -- 44,167,127(-) GTCAG(A/G)TAATG intron-variant
rs914502 -- 44,167,116(-) GCTGA(A/G)CAGGT intron-variant
rs914503 -- 44,166,844(-) CGACG(A/G)GTCTG intron-variant
rs1418487 -- 44,172,538(+) TTTGG(A/G)CTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAPN11 Gene

Variant ID Type Subtype PubMed ID
nsv509132 CNV Insertion 20534489
esv2732004 CNV Deletion 23290073
esv2292197 CNV Deletion 18987734
esv2732005 CNV Deletion 23290073
esv2732007 CNV Deletion 23290073
esv2732008 CNV Deletion 23290073
esv2732009 CNV Deletion 23290073
dgv1050e201 CNV Deletion 23290073
nsv510028 CNV Loss 20534489
esv1646210 CNV Deletion 17803354
esv2732011 CNV Deletion 23290073
esv1158501 CNV Deletion 17803354

Relevant External Links for CAPN11 Gene

HapMap Linkage Disequilibrium report
CAPN11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPN11 Gene

Disorders for CAPN11 Gene

No disorders were found for CAPN11 Gene.

No data available for UniProtKB/Swiss-Prot for CAPN11 Gene

Publications for CAPN11 Gene

  1. CAPN11: a calpain with high mRNA levels in testis and located on chromosome 6. (PMID: 10409436) Dear T.N. … Boehm T. (Genomics 1999) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Calpain 11 is unique to mouse spermatogenic cells. (PMID: 16541461) Ben-Aharon I. … Eddy E.M. (Mol. Reprod. Dev. 2006) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for CAPN11 Gene

Sources for CAPN11 Gene

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