Aliases for CAPN11 Gene
External Ids for CAPN11 Gene
Previous GeneCards Identifiers for CAPN11 Gene
Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis. [provided by RefSeq, Dec 2008]
GeneCards Summary for CAPN11 Gene
CAPN11 (Calpain 11) is a Protein Coding gene. Among its related pathways are Arrhythmogenic right ventricular cardiomyopathy (ARVC) and DREAM Repression and Dynorphin Expression. GO annotations related to this gene include calcium ion binding and calcium-dependent cysteine-type endopeptidase activity. An important paralog of this gene is CAPN1.
UniProtKB/Swiss-Prot for CAPN11 Gene
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure.