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Aliases for CAPN11 Gene

Aliases for CAPN11 Gene

  • Calpain 11 2 3 5
  • Calcium-Activated Neutral Proteinase 11 3 4
  • CANP 11 3 4
  • EC 3.4.22.54 61
  • EC 3.4.22.52 61
  • EC 3.4.22.- 4
  • Calpain-11 3
  • Calpain11 3
  • EC 3.4.22 61

External Ids for CAPN11 Gene

Previous GeneCards Identifiers for CAPN11 Gene

  • GC06P044128
  • GC06P044173
  • GC06P044235
  • GC06P043847

Summaries for CAPN11 Gene

Entrez Gene Summary for CAPN11 Gene

  • Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis. [provided by RefSeq, Dec 2008]

GeneCards Summary for CAPN11 Gene

CAPN11 (Calpain 11) is a Protein Coding gene. Among its related pathways are Arrhythmogenic right ventricular cardiomyopathy (ARVC) and DREAM Repression and Dynorphin Expression. GO annotations related to this gene include calcium ion binding and calcium-dependent cysteine-type endopeptidase activity. An important paralog of this gene is CAPN1.

UniProtKB/Swiss-Prot for CAPN11 Gene

  • Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

Tocris Summary for CAPN11 Gene

  • Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPN11 Gene

Genomics for CAPN11 Gene

Regulatory Elements for CAPN11 Gene

Enhancers for CAPN11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F044200 0.8 Ensembl ENCODE 21.8 +43.6 43566 3.8 PKNOX1 CREB3L1 GATA2 FOS SP5 NCOA1 REST PPARG SREBF1 SMARCA4 SLC29A1 CAPN11 HSP90AB1 NFKBIE TMEM151B SLC35B2 MIR4647 MRPL14 TMEM63B LOC101929726
GH06F044232 1.5 FANTOM5 Ensembl ENCODE 21.8 +77.1 77067 6.4 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 POLH CAPN11 RPS2P29 NFKBIE SLC35B2 MIR4647 MRPL14 TMEM63B TMEM151B LOC101929726
GH06F044172 1.3 Ensembl ENCODE 18 +14.0 14034 1.1 ELF3 HDGF HDAC1 ATF1 PKNOX1 TBL1XR1 SIN3A KLF17 ARID4B ZNF48 CAPN11 SLC29A1 LOC105375072
GH06F043836 1 FANTOM5 Ensembl 15.3 -322.2 -322210 0.4 PKNOX1 ATF1 ARNT MLX ZNF48 YY1 SLC30A9 ELK1 GATA2 FOS CAPN11 CDC5L TCTE1 VEGFA RSPH9 LRRC73 ABCC10 MAD2L1BP LOC105375069 LOC105375070
GH06F044094 0.8 ENCODE 12.3 -63.9 -63903 1.8 HDGF PKNOX1 MLX ARID4B DMAP1 SLC30A9 ZNF766 CBX5 ZNF143 FOS MRPL14 AARS2 TMEM63B CUL9 CAPN11 VEGFA SLC29A1 HSP90AB1 MIR4647 SLC35B2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CAPN11 on UCSC Golden Path with GeneCards custom track

Genomic Location for CAPN11 Gene

Chromosome:
6
Start:
44,158,811 bp from pter
End:
44,184,402 bp from pter
Size:
25,592 bases
Orientation:
Plus strand

Genomic View for CAPN11 Gene

Genes around CAPN11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPN11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPN11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPN11 Gene

Proteins for CAPN11 Gene

  • Protein details for CAPN11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UMQ6-CAN11_HUMAN
    Recommended name:
    Calpain-11
    Protein Accession:
    Q9UMQ6
    Secondary Accessions:
    • B2RA64
    • Q5T3G1
    • Q8N4R5

    Protein attributes for CAPN11 Gene

    Size:
    739 amino acids
    Molecular mass:
    84423 Da
    Quaternary structure:
    • Heterodimer of a large (catalytic) and a small (regulatory) subunit.
    SequenceCaution:
    • Sequence=AAH33733.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG36761.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB52137.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CAPN11 Gene

Selected DME Specific Peptides for CAPN11 Gene

Q9UMQ6:
  • LGDCWLLA
  • YEALSGG
  • PSTFEPH
  • LEICNLTPD
  • LFEDPLFPA
  • TFWTNPQ
  • IDFDSFI
  • YAGIFHF
  • KLVFVHS
  • LLEKAYAK
  • EDFTGGV

Post-translational modifications for CAPN11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAPN11 Gene

Domains & Families for CAPN11 Gene

Gene Families for CAPN11 Gene

Suggested Antigen Peptide Sequences for CAPN11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UMQ6

UniProtKB/Swiss-Prot:

CAN11_HUMAN :
  • Contains 1 calpain catalytic domain.
  • Belongs to the peptidase C2 family.
Domain:
  • Contains 1 calpain catalytic domain.
  • Contains 2 EF-hand domains.
Family:
  • Belongs to the peptidase C2 family.
genes like me logo Genes that share domains with CAPN11: view

Function for CAPN11 Gene

Molecular function for CAPN11 Gene

GENATLAS Biochemistry:
calpain 11,large polypeptide 11,calcium dependent,neutral cysteine proteinase,papain superfamily expressed in the testis
UniProtKB/Swiss-Prot CatalyticActivity:
Broad endopeptidase specificity.
UniProtKB/Swiss-Prot Function:
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

Enzyme Numbers (IUBMB) for CAPN11 Gene

Gene Ontology (GO) - Molecular Function for CAPN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004198 calcium-dependent cysteine-type endopeptidase activity IEA,TAS --
GO:0005509 calcium ion binding IEA --
GO:0008233 peptidase activity TAS 10409436
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CAPN11: view
genes like me logo Genes that share phenotypes with CAPN11: view

Animal Models for CAPN11 Gene

MGI Knock Outs for CAPN11:

Animal Model Products

miRNA for CAPN11 Gene

miRTarBase miRNAs that target CAPN11

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAPN11 Gene

Localization for CAPN11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPN11 Gene

Cytoplasmic vesicle, secretory vesicle, acrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAPN11 Gene COMPARTMENTS Subcellular localization image for CAPN11 gene
Compartment Confidence
cytosol 3
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CAPN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IBA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with CAPN11: view

Pathways & Interactions for CAPN11 Gene

genes like me logo Genes that share pathways with CAPN11: view

Pathways by source for CAPN11 Gene

Gene Ontology (GO) - Biological Process for CAPN11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with CAPN11: view

No data available for SIGNOR curated interactions for CAPN11 Gene

Drugs & Compounds for CAPN11 Gene

(2) Drugs for CAPN11 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
Acetyl-Calpastatin (184-210) (human) Pharma Calpain I/II inhibitor, Selective calpain inhibitor 0

(1) Additional Compounds for CAPN11 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
MG 132
133407-82-6

(2) Tocris Compounds for CAPN11 Gene

Compound Action Cas Number
Acetyl-Calpastatin (184-210) (human) Selective calpain inhibitor 123714-50-1
MG 132 Proteasome and calpain inhibitor. Inhibits NF-kappaB activation 133407-82-6
genes like me logo Genes that share compounds with CAPN11: view

Transcripts for CAPN11 Gene

Unigene Clusters for CAPN11 Gene

Calpain 11:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAPN11 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - -
SP2: -
SP3: - -
SP4: - -
SP5: -
SP6:
SP7: -

ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for CAPN11 Gene

GeneLoc Exon Structure for
CAPN11
ECgene alternative splicing isoforms for
CAPN11

Expression for CAPN11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CAPN11 Gene

mRNA differential expression in normal tissues according to GTEx for CAPN11 Gene

This gene is overexpressed in Testis (x27.2).

Protein differential expression in normal tissues from HIPED for CAPN11 Gene

This gene is overexpressed in Liver (24.8), Spleen (12.7), Kidney (12.5), and Platelet (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CAPN11 Gene



NURSA nuclear receptor signaling pathways regulating expression of CAPN11 Gene:

CAPN11

SOURCE GeneReport for Unigene cluster for CAPN11 Gene:

Hs.225953

mRNA Expression by UniProt/SwissProt for CAPN11 Gene:

Q9UMQ6-CAN11_HUMAN
Tissue specificity: Highest expression in testis.
genes like me logo Genes that share expression patterns with CAPN11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for CAPN11 Gene

Orthologs for CAPN11 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPN11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAPN11 34 35
  • 98.83 (n)
cow
(Bos Taurus)
Mammalia CAPN11 34 35
  • 84.16 (n)
dog
(Canis familiaris)
Mammalia CAPN11 34 35
  • 84 (n)
mouse
(Mus musculus)
Mammalia Capn11 34 16 35
  • 79.6 (n)
rat
(Rattus norvegicus)
Mammalia Capn11 34
  • 79.2 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:85932 35
  • 35 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CalpA 36 35
  • 47 (a)
CalpB 36 35
  • 41 (a)
CalpC 36
  • 29 (a)
worm
(Caenorhabditis elegans)
Secernentea clp-7 36 35
  • 43 (a)
clp-6 36 35
  • 40 (a)
clp-3 36 35
  • 36 (a)
clp-4 35
  • 31 (a)
ManyToMany
clp-1 35
  • 30 (a)
ManyToMany
Species where no ortholog for CAPN11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CAPN11 Gene

ENSEMBL:
Gene Tree for CAPN11 (if available)
TreeFam:
Gene Tree for CAPN11 (if available)

Paralogs for CAPN11 Gene

Paralogs for CAPN11 Gene

(14) SIMAP similar genes for CAPN11 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CAPN11: view

Variants for CAPN11 Gene

Sequence variations from dbSNP and Humsavar for CAPN11 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10807296 -- 44,177,569(+) TGCAA(A/C)CTCAG intron-variant
rs10948127 -- 44,173,948(+) ATTAT(C/G)TTGCT intron-variant
rs111161411 -- 44,181,662(+) CACAC(A/T)CACAC intron-variant
rs111161412 -- 44,181,669(+) ACACA(C/T)ACATA intron-variant
rs111161414 -- 44,181,953(+) CACAC(A/T)CACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAPN11 Gene

Variant ID Type Subtype PubMed ID
dgv1003e201 CNV deletion 23290073
dgv3506e59 CNV duplication 20981092
esv1158501 CNV deletion 17803354
esv1646210 CNV deletion 17803354
esv2292197 CNV deletion 18987734
esv2732004 CNV deletion 23290073
esv2732005 CNV deletion 23290073
esv2732007 CNV deletion 23290073
esv2732008 CNV deletion 23290073
esv2732009 CNV deletion 23290073
esv2732011 CNV deletion 23290073
esv3608825 CNV loss 21293372
esv3608826 CNV gain 21293372
nsv1110794 CNV insertion 24896259
nsv1135962 CNV deletion 24896259
nsv509132 CNV insertion 20534489
nsv510028 OTHER sequence alteration 20534489
nsv958346 CNV deletion 24416366

Variation tolerance for CAPN11 Gene

Residual Variation Intolerance Score: 85.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.36; 90.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAPN11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAPN11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPN11 Gene

Disorders for CAPN11 Gene

Relevant External Links for CAPN11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAPN11

No disorders were found for CAPN11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAPN11 Gene

Publications for CAPN11 Gene

  1. CAPN11: a calpain with high mRNA levels in testis and located on chromosome 6. (PMID: 10409436) Dear T.N. … Boehm T. (Genomics 1999) 2 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3 64
  5. Characterisation of capn1, capn2-like, capn3 and capn11 genes in Atlantic halibut (Hippoglossus hippoglossus L.): Transcriptional regulation across tissues and in skeletal muscle at distinct nutritional states. (PMID: 20093171) Macqueen D.J. … Johnston I.A. (Gene 2010) 22 64

Products for CAPN11 Gene

Sources for CAPN11 Gene

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