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Aliases for CAPN10 Gene

Aliases for CAPN10 Gene

  • Calpain 10 2 3
  • Calcium-Activated Neutral Proteinase 10 3 4
  • NIDDM1 3 6
  • Calpain-Like Protease CAPN10 3
  • EC 3.4.22.- 4
  • Calpain-10 3
  • KIAA1845 4
  • CANP 10 4
  • CANP10 3

External Ids for CAPN10 Gene

Summaries for CAPN10 Gene

Entrez Gene Summary for CAPN10 Gene

  • Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq, Sep 2010]

GeneCards Summary for CAPN10 Gene

CAPN10 (Calpain 10) is a Protein Coding gene. Diseases associated with CAPN10 include polycystic ovary syndrome and hyperandrogenism. Among its related pathways are ERK Signaling and Apoptosis Pathway. GO annotations related to this gene include cytoskeletal protein binding and SNARE binding. An important paralog of this gene is CAPN9.

UniProtKB/Swiss-Prot for CAPN10 Gene

  • Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake.

Tocris Summary for CAPN10 Gene

  • Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. This family contains 14 members with mu-calpain (calpain 1) and m-calpain (calpain 2) being the most well-characterized. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure. Calpains are regulated by Ca2+ concentration, phosphorylation, calpastatin and probably by altering their subcellular localization (limiting access to substrate). These endopeptidases have numerous functions including, but not limited to, remodeling of cytoskeletal attachments to the plasma membrane during cell fusion and cell motility, proteolytic modification of molecules in signal transduction pathways, degradation of enzymes controlling progression through the cell cycle, regulation of gene expression, substrate degradation in some apoptotic pathways, and an involvement in long-term potentiation. Perturbations in calpain activity have been associated in pathophysiological processes contributing to type II diabetes (calpain 10), Alzheimers disease (calpain 1), gastric cancer (calpain 9) and muscular dystrophy (calpain 3).

Gene Wiki entry for CAPN10 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPN10 Gene

Genomics for CAPN10 Gene

Genomic Location for CAPN10 Gene

Start:
240,586,716 bp from pter
End:
240,617,705 bp from pter
Size:
30,990 bases
Orientation:
Plus strand

Genomic View for CAPN10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAPN10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPN10 Gene

Regulatory Elements for CAPN10 Gene

Transcription factor binding sites by QIAGEN in the CAPN10 gene promoter:

Proteins for CAPN10 Gene

  • Protein details for CAPN10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HC96-CAN10_HUMAN
    Recommended name:
    Calpain-10
    Protein Accession:
    Q9HC96
    Secondary Accessions:
    • A8MVS7
    • Q4ZFV1
    • Q8NCD4
    • Q96IG4
    • Q96JI2
    • Q9HC89
    • Q9HC90
    • Q9HC91
    • Q9HC92
    • Q9HC93
    • Q9HC94
    • Q9HC95

    Protein attributes for CAPN10 Gene

    Size:
    672 amino acids
    Molecular mass:
    74952 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB47474.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CAPN10 Gene

neXtProt entry for CAPN10 Gene

Proteomics data for CAPN10 Gene at MOPED

Post-translational modifications for CAPN10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CAPN10 Gene

Domains for CAPN10 Gene

UniProtKB/Swiss-Prot:

CAN10_HUMAN
Domain:
  • Contains 1 calpain catalytic domain.:
    • Q9HC96
Family:
  • Belongs to the peptidase C2 family.:
    • Q9HC96
genes like me logo Genes that share domains with CAPN10: view

No data available for Gene Families for CAPN10 Gene

Function for CAPN10 Gene

Molecular function for CAPN10 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Broad endopeptidase specificity
UniProtKB/Swiss-Prot Function: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake.

Enzyme Numbers (IUBMB) for CAPN10 Gene

Gene Ontology (GO) - Molecular Function for CAPN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding ISS --
GO:0004198 calcium-dependent cysteine-type endopeptidase activity IMP 15044459
GO:0008092 cytoskeletal protein binding ISS --
genes like me logo Genes that share ontologies with CAPN10: view
genes like me logo Genes that share phenotypes with CAPN10: view

Animal Models for CAPN10 Gene

MGI Knock Outs for CAPN10:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for CAPN10 Gene

Localization for CAPN10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAPN10 Gene COMPARTMENTS Subcellular localization image for CAPN10 gene
Compartment Confidence
cytosol 3
plasma membrane 3
mitochondrion 2
endoplasmic reticulum 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CAPN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005623 cell IDA 17572128
GO:0005739 mitochondrion IDA 16790502
GO:0005829 cytosol ISS --
GO:0005886 plasma membrane ISS --
genes like me logo Genes that share ontologies with CAPN10: view

Pathways for CAPN10 Gene

genes like me logo Genes that share pathways with CAPN10: view

Pathways by source for CAPN10 Gene

1 BioSystems pathway for CAPN10 Gene

Interacting Proteins for CAPN10 Gene

Gene Ontology (GO) - Biological Process for CAPN10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IMP 15044459
GO:0006921 cellular component disassembly involved in execution phase of apoptosis IC --
GO:0031532 actin cytoskeleton reorganization ISS 12974673
GO:0032024 positive regulation of insulin secretion IMP 15471947
GO:0032388 positive regulation of intracellular transport ISS 12974673
genes like me logo Genes that share ontologies with CAPN10: view

Compounds for CAPN10 Gene

(9) ApexBio Compounds for CAPN10 Gene

Compound Action Cas Number
Acetyl-Calpastatin (184-210) (human) Selective calpain inhibitor. [123714-50-1]
Calpain Inhibitor I, ALLN A cell-permeable inhibitor of calpain I, calpain II, cathepsin B, and cathepsin L. [110044-82-1]
Calpain Inhibitor II, ALLM A cell-permeable inhibitor of calpain 1 and calpain 2. [136632-32-1]
Calpeptin Potent cathepsin L inhibitor [117591-20-5]
E-64 Irriversible cysteine protease inhibitor [66701-25-5]
MDL 28170 Potent, selective inhibitor of calpain and cathepsin B. [88191-84-8]
MG-132 Proteasome and calpain inhibitor. [133407-82-6]
PD 150606 Selective, cell-permeable non-peptide calpain inhibitor. [179528-45-1]
Z-FA-FMK An inhibitor of cysteine proteases, such as cathepsin B.

(5) Tocris Compounds for CAPN10 Gene

Compound Action Cas Number
Acetyl-Calpastatin (184-210) (human) Selective calpain inhibitor [123714-50-1]
MDL 28170 Potent, selective calpain and cathepsin B inhibitor [88191-84-8]
MG 101 Calpain inhibitor; activates p53-dependent apoptosis [110044-82-1]
MG 132 Proteasome and calpain inhibitor. Inhibits NF-kappaB activation [133407-82-6]
PD 150606 Cell permeable calpain inhibitor [179528-45-1]

(1) HMDB Compounds for CAPN10 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(8) Novoseek inferred chemical compound relationships for CAPN10 Gene

Compound -log(P) Hits PubMed IDs
glucose 51.1 24
cysteine 48.3 9
potassium 6.43 3
glycogen 4.75 2
calcium 4.39 1
genes like me logo Genes that share compounds with CAPN10: view

Transcripts for CAPN10 Gene

Unigene Clusters for CAPN10 Gene

Calpain 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAPN10 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ·
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - - -
SP7: -
SP8: - - -
SP9:
SP10:
SP11:
SP12:
SP13: - - - - - - - - - - - - - - - - - - - - - - -
SP14: - - - - - - - - - - - - - - - - - -
SP15:
SP16: -
SP17:

ExUns: 16c ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: - - -
SP10:
SP11: - -
SP12: -
SP13: - - -
SP14:
SP15:
SP16:
SP17:

Relevant External Links for CAPN10 Gene

GeneLoc Exon Structure for
CAPN10
ECgene alternative splicing isoforms for
CAPN10

Expression for CAPN10 Gene

mRNA expression in normal human tissues for CAPN10 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CAPN10 Gene

SOURCE GeneReport for Unigene cluster for CAPN10 Gene Hs.728234

mRNA Expression by UniProt/SwissProt for CAPN10 Gene

Q9HC96-CAN10_HUMAN
Tissue specificity: Detected in primary skeletal muscle cells (at protein level). Ubiquitous.
genes like me logo Genes that share expressions with CAPN10: view

Orthologs for CAPN10 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPN10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAPN10 36
  • 98.31 (n)
  • 97.7 (a)
CAPN10 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CAPN10 37
  • 85 (a)
OneToOne
LOC789674 36
  • 85.03 (n)
  • 84.75 (a)
dog
(Canis familiaris)
Mammalia CAPN10 36
  • 84.74 (n)
  • 82.18 (a)
CAPN10 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Capn10 36
  • 82.41 (n)
  • 81.95 (a)
Capn10 16
Capn10 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CAPN10 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 66 (a)
OneToMany
-- 37
  • 72 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Capn10 36
  • 82.56 (n)
  • 81.8 (a)
chicken
(Gallus gallus)
Aves CAPN10 36
  • 65.55 (n)
  • 66.16 (a)
lizard
(Anolis carolinensis)
Reptilia CAPN10 37
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia capn10 36
  • 56.05 (n)
  • 52.77 (a)
zebrafish
(Danio rerio)
Actinopterygii capn10 36
  • 57.69 (n)
  • 52.9 (a)
capn10 37
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CalpC 37
  • 22 (a)
OneToOne
Species with no ortholog for CAPN10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAPN10 Gene

ENSEMBL:
Gene Tree for CAPN10 (if available)
TreeFam:
Gene Tree for CAPN10 (if available)

Paralogs for CAPN10 Gene

Selected SIMAP similar genes for CAPN10 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CAPN10: view

Variants for CAPN10 Gene

Sequence variations from dbSNP and Humsavar for CAPN10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2953168 -- 240,599,586(-) AATCC(C/T)AGGAC downstream-variant-500B
rs2953169 -- 240,599,518(-) GTCCA(C/T)GTGAA downstream-variant-500B
rs2953170 -- 240,599,000(-) GTGTG(A/G)GGCCT utr-variant-3-prime
rs2953171 -- 240,596,636(-) TTCCC(A/G)GTGGC intron-variant
rs2975756 -- 240,590,567(+) TGCCG(A/T)AGAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAPN10 Gene

Variant ID Type Subtype PubMed ID
nsv876116 CNV Loss 21882294
nsv876125 CNV Loss 21882294
dgv1295e1 CNV Complex 17122850
nsv876132 CNV Loss 21882294
nsv834586 CNV Loss 17160897
dgv4471n71 CNV Loss 21882294
dgv4472n71 CNV Loss 21882294
nsv876144 CNV Loss 21882294
dgv4473n71 CNV Loss 21882294
nsv876148 CNV Loss 21882294
nsv876157 CNV Loss 21882294
nsv876160 CNV Loss 21882294
nsv470529 CNV Loss 18288195
dgv4477n71 CNV Loss 21882294

Relevant External Links for CAPN10 Gene

HapMap Linkage Disequilibrium report
CAPN10
Human Gene Mutation Database (HGMD)
CAPN10

Disorders for CAPN10 Gene

(1) OMIM Diseases for CAPN10 Gene (605286)

UniProtKB/Swiss-Prot

CAN10_HUMAN
  • Diabetes mellitus, non-insulin-dependent, 1 (NIDDM1) [MIM:601283]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the bodys own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269 PubMed:11017071, ECO:0000269 PubMed:16721485}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for CAPN10 Gene

(22) Novoseek inferred disease relationships for CAPN10 Gene

Disease -log(P) Hits PubMed IDs
niddm 67 13
polycystic ovary syndrome 65.7 11
lgmd2a 60 1
insulin resistance 57 17
impaired glucose tolerance 53.9 1

Relevant External Links for CAPN10

Genetic Association Database (GAD)
CAPN10
Human Genome Epidemiology (HuGE) Navigator
CAPN10
genes like me logo Genes that share disorders with CAPN10: view

Publications for CAPN10 Gene

  1. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. (PMID: 11017071) Horikawa Y. … Bell G.I. (Nat. Genet. 2000) 2 3 4 23 49
  2. A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance. (PMID: 11018080) Baier L.J. … Bogardus C. (J. Clin. Invest. 2000) 2 3 23 49
  3. A novel 111/121 diplotype in the Calpain-10 gene is associated with type 2 diabetes. (PMID: 16721485) Kang E.S. … Lee H.C. (J. Hum. Genet. 2006) 3 4 23 49
  4. Calpain 10 and development of diabetes mellitus in cystic fibrosis. (PMID: 16377260) Derbel S. … Bienvenu T. (J. Cyst. Fibros. 2006) 3 23 49
  5. Polymorphisms of interleukin-6, hepatic lipase and calpain-10 genes, and preeclampsia. (PMID: 16427731) Saarela T. … Laakso M. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2006) 3 23 49

Products for CAPN10 Gene

Sources for CAPN10 Gene

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