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CAPN1 Gene

protein-coding GIFtS: 66

GC11P064705

calpain 1, (mu/I) large subunit
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CANP ^¹, ²
CANP1 ^²
CANPL1 ^¹, ², ³
EC 3.4.22.52 ^³
Micromolar-calpain ^³
muCANP ^¹, ², ³
muCL ^¹, ²

Descriptions
CANP 1 ^³
Calcium-activated neutral proteinase 1 ^³
Calpain mu-type ^³
Calpain-1 large subunit ^³
Cell proliferation-inducing gene 30 protein ^³
calcium-activated neutral proteinase ^²
calpain 1, (mu/I) large subunit ^²
calpain 1, large subunit ^²
calpain, large polypeptide L1 ^²
cell proliferation-inducing protein 30 ^²

External Ids
HGNC: 1476¹
Entrez Gene: 823²
UniProtKB: P07384³
Ensembl: ENSG00000014216⁷

Search outside databases for aliases for CAPN1 gene

Previous GC identifers: GC11P067465 GC11P066630 GC11P065198 GC11P064724

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CAPN1:

The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine

proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific

proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits

associated with a common small, regulatory subunit. This gene encodes the large subunit of the

ubiquitous enzyme, calpain 1. [provided by RefSeq]

UniProtKB/Swiss-Prot: CAN1_HUMAN, P07384

Function: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of

substrates involved in cytoskeletal remodeling and signal transduction

Gene Wiki entry for CAPN1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CAPN1 gene

Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13

CAPN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P064705: (about GC identifiers)

Start:	64,705,919 bp from pter
End:	64,736,052 bp from pter
Size:	30,134 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.8 NT_033903.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CAN1_HUMAN, P07384 (See protein sequence)

Recommended Name: Calpain-1 catalytic subunit

Size: 714 amino acids; 81890 Da

Cofactor: Binds 3 calcium ions

Subunit: Forms a heterodimer with a small (regulatory) subunit (CAPNS1)

Subcellular location: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Translocates

to the plasma membrane upon Ca(2+) binding (By similarity)

PDB structure from and Proteopedia :

1ZCM (3D)

2ARY (3D)

Secondary accessions: Q2TTR0 Q6DHV4

REFSEQ proteins: NP_005177.2

ENSEMBL proteins:

ENSP00000279247

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for CAPN1
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Calpain, Calpain 1)
	Human Recombinant Proteins from Abnova (CAPN1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005886	plasma membrane	IEA	--

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Antibodies for CAPN1:

	Invitrogen Antibodies for CAPN1
	Millipore Mono- and Polyclonal Antibodies for the study of CAPN1
	Sigma-Aldrich Antibodies for CAPN1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for CAPN1 (Calpain 1)
	Antibodies from Abcam (Calpain, Calpain 1), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for CAPN1

Assays for CAPN1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P07384

ProtoNet protein and cluster: P07384

1 Blocks protein family: IPB001300 Calpain cysteine protease (C2) family signature

UniProtKB/Swiss-Prot: CAN1_HUMAN, P07384

Similarity: Belongs to the peptidase C2 family

Similarity: Contains 1 calpain catalytic domain

Similarity: Contains 4 EF-hand domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CAPN1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CAPN1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005186

Applied Biosystems Silencer® siRNAs for CAPN1

Sigma-Aldrich siRNA and siRNA Panels for CAPN1

Sigma-Aldrich shRNA Panels and shRNA for CAPN1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CAPN1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005186
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005186
untagged cDNA clone in CMV expression vector: NM_005186

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005186

UniProtKB/Swiss-Prot: CAN1_HUMAN, P07384

Function: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of

substrates involved in cytoskeletal remodeling and signal transduction

Catalytic activity: Broad endopeptidase specificity

Enzyme regulation: Activated by micromolar concentrations of calcium and inhibited by calpastatin

Enzyme Number (IUBMB): EC 3.4.22.52

Genatlas biochemistry entry for CAPN1:

calpain,large polypeptide L1,calcium dependent neutral cysteine proteinase,papain superfamily,mu

type (not mutated in MEN1)

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Capn1):

hematopoietic system

homeostasis/metabolism

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	IEA	--
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	15935327
GO:0008233	peptidase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for CAPN1 (Your Favorite Gene powered by Ingenuity) (see all 6 )

CDK5 Signaling
Integrin Signaling
Amyloid Processing
Apoptosis Signaling
Huntington's Disease Signaling

GeneDecks CAPN1 for the pathways selected above

About GeneDecksing

5/18 Interacting proteins for CAPN1 (ENSP00000279247³ P07384^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 18 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTPN1	P18031²	STRING (score=.967) MINT-6793387
RCAN1	P53805-2¹	EBI-1542113, EBI-1541912
TTN	ENSP00000340554³	STRING (score=.953)
GANC	ENSP00000326227³	STRING (score=.952)
CAST	ENSP00000339914³	STRING (score=.943)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--
GO:0008284	positive regulation of cell proliferation	TAS	8702541

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for CAPN1

Sigma-Aldrich Small Molecules for CAPN1:

Inhibitor

Compounds for CAPN1 available from Tocris Bioscience

Compound	Action	CAS number
MDL 28170	Potent, selective calpain and cathepsin B inhibitor	[88191-84-8]
Calpeptin	Calpain and cathepsin L inhibitor	[117591-20-5]
MG 132	Proteasome and calpain inhibitor. Inhibits NF-kappaB activation	[133407-82-6]
MG 101	Calpain inhibitor; activates p53-dependent apoptosis	[110044-82-1]
Acetyl-Calpastatin (184-210) (human)	Selective calpain inhibitor	[123714-50-1]

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10/11 Novoseek chemical compound relationships for CAPN1 gene (see all 11 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
calcium	54.49	83	16107503 (5), 7961733 (4), 9210524 (3), 1400400 (3) (see all 37)
ionomycin	33.75	4	7982901 (2), 12393869 (1), 16081284 (1)
peroxynitrite	16.32	2	15650007 (1), 18071073 (1)
nacl	9.74	11	10641868 (2), 9972251 (1)
atp	0.00	1	7782321 (1)
superoxide	0.00	1	15372247 (1)
nitric oxide	0.00	2	17690304 (2)
ethanol	0.00	7	11084212 (2), 9109511 (1)
adp	0.00	1	15372247 (1)
tyrosine	0.00	6	9677317 (2), 18071073 (2), 9312088 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CAPN1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CAPN1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005186

Sigma-Aldrich siRNA and siRNA Panels for CAPN1

Sigma-Aldrich shRNA Panels and shRNA for CAPN1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005186

REFSEQ mRNAs for CAPN1 gene:

NM_005186.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005186

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005186
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005186
                                 untagged cDNA clone in CMV expression vector: NM_005186

Additional cDNA sequence:

AK022319.1 AK025380.1 AK097277.1 AK301538.1 AK311001.1 AK315556.1 AY550975.1 BC008751.2

BC015091.2 BC017200.2 BC075862.1 X04366.1

24/37 DOTS entries (see all 37 ):

DT.447394 DT.97864406 DT.86840162 DT.75199128 DT.100846351 DT.95189131 DT.100846348 DT.100846341

DT.95365707 DT.95341266 DT.100846346 DT.95189126 DT.120728821 DT.100846343 DT.100846354 DT.120728803

DT.91773350 DT.120728779 DT.120728788 DT.100712092 DT.120728851 DT.95189138 DT.120728832 DT.75199127

24/670 AceView cDNA sequences (see all 670 ):

BG170963 BI820433 BE887298 BG292133 BQ002160 BX446678 AW778834 BU146807

BE259281 BQ024432 CB243815 AL548580 BQ056880 BQ057563 AI470066 BQ877831

BQ962226 AW083107 AI752051 AU130839 CA489527 BQ684996 BE907919 CA748622

highest scoring ESTs for CAPN1:

X04366 AA099375 AA394281 AA776189 AA779377 AA863164 AI125947 AI133437 AI452945 AI470066

Unigene Cluster for CAPN1:

Calpain 1, (mu/I) large subunit

Hs.502842 [show with all ESTs]

Unigene Representative Sequence: BC008751

GeneLoc Exon Structure

5/23 Alternative Splicing Database (ASD) splice patterns (SP) for CAPN1 (see all 23 )

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	·	7d	·	7e	·	7f	^	8	^	9	^	10a	·	10b	^	11a	·	11b	·	11c	·	11d	·	11e	^	12a	·	12b	·	12c	·
SP1:
SP2:																																													-		-
SP3:															-		-		-		-		-		-		-																		-		-
SP4:					-		-		-		-		-		-		-		-		-		-		-		-																		-		-
SP5:

ExUns:	12d	·	12e	^	13a	·	13b	^	14a	·	14b	·	14c	·	14d	^	15a	·	15b	·	15c	^	16	^	17a	·	17b	^	18	^	19	^	20a	·	20b	^	21	^	22	^	23	^	24	^	25a	·	25b	·	25c	^	26	^
SP1:																																													-		-
SP2:															-		-
SP3:															-		-
SP4:
SP5:															-		-												-		-

ExUns:	27	^	28a	·	28b	^	29	^	30a	·	30b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for CAPN1

1 Ensembl transcript including schematic representation:

ENST00000279247

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CAPN1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CAPN1

¹ / ² / ³

6 probe-sets matching CAPN1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
62648_at²^{, 3}	U95-C	1	1.00	1.00	0.76	0.95	AA813065	0.20	0.33	0.27	2
33908_at²^{, 3}	U95-A	1	1.00	1.00	0.65	1.05	X04366	1.00	1.00	1.00	1
200752_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005186	0.60	1.00	0.82	1
232012_at²	U133-B	1	0.91	1.00	--	--	--	--	--	--	--
200752_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
232012_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGCTCGGGAT

SOURCE GeneReport for Unigene cluster: Hs.502842
Expression variation in blood from EXPOLDB for CAPN1
UniProtKB/Swiss-Prot: CAN1_HUMAN, P07384
Tissue specificity: Ubiquitous

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CAPN1 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CAPN1¹	--	calpain 1, (mu/I) large subunit	91.8(n) 97.05(a)	483745 XM_540866.2 XP_540866.2
chimpanzee (Pan troglodytes)	CAPN1¹	--	calpain 1, (mu/I) large subunit	99.25(n) 99.72(a)	451317 XM_001169100.1 XP_001169100.1
cow (Bos taurus)	CAPN1¹	--	calpain 1, (mu/I) large subunit	90.99(n) 94.96(a)	281661 NM_174259.2 NP_776684.1
rat (Rattus norvegicus)	Capn1¹	--	calpain 1	85.79(n) 89.34(a)	29153 NM_019152.2 NP_062025.1
mouse (Mus musculus)	Capn1^{1, 5}	19 (3.00 cM)⁵	calpain 1^{1, 5}	86.07(n)¹ 89.34(a)¹	12333¹ NM_007600.2¹ NP_031626.1¹ AF021847⁵ AF084459⁵ (see all 24)

About this table Species with no ortholog for CAPN1

ENSEMBL Gene Tree for CAPN1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CAPN1 gene

CAPN2² CAPN8²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/204 NCBI SNPs in CAPN1 are shown (see all 204 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 110)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3953797^1,2	A,C,F,H	64704853(+)	`ACAACA/CTGCAA`	1	--	ng5¹		5	EU EA WA	582
--	rs12422027^1,2	A,C,F	64705131(+)	`GAGAGA/GACAGG`	1	--	ng5¹ tfbs³ trp³		2	MN EA	1252
	rs10895991^1,2	C,F,H	64728862(+)	`GCGCCG/CCTTCG`	1	P/R	mis¹ ese³		6	NS EU EA WA	748
--	rs1129366^1,2	F	64704254(-)	`GTAGAG/AATGGG`	1	--	ng5¹		1	MN	184
	rs17880457^1,2	F	64705695(+)	`CCGCGG/ATGCCC`	1	--	ng5¹		1	NS	132
--	rs17855397^1,2	H	64732140(+)	`TTCAAG/TGCCCT`	1	K/N	mis¹ ese³		4	EU EA WA	418
	rs17583^1,2	C,F,H	64707546(+)	`GCCATC/TGCCTC`	1	I/I	syn¹		11	MN NS EU EA WA NA	1158
	rs17880800^1,2	C,F	64706907(+)	`AGTGGG/AACCCT`	1	G/G	syn¹ ese³		2	NS NA	248
	rs11826089^1,2	H	64728884(+)	`GAGACT/AATTGG`	1	T/T	syn¹ ese³		4	EU EA WA	414
	rs2271449^1,2	A,C,F,H,O	64733735(-)	`GCTTGC/TCTTAT`	1	--	int¹		10	EA NA NS EU WA	2370

About this table

HapMap Linkage Disequilibrium images for CAPN1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 114220

10/11 Novoseek disease relationships for CAPN1 gene (see all 11 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
brain ischemia	28.63	1	10072294 (1)
alzheimers disease	8.64	5	8737608 (1), 8622780 (1), 18396356 (1), 19041242 (1)
cancer	3.58	2	16461767 (1), 16081284 (1)
associated conditions	2.93	1	7982901 (1)
necrosis	0.00	2	16574073 (1), 17180042 (1)
breast cancer	0.00	3	15358198 (1), 12750552 (1), 16081284 (1)
tumors	0.00	2	16574073 (1), 17180042 (1)
carcinoma squamous cell	0.00	3	12635142 (1), 7982901 (1)
stroke	0.00	3	18396356 (1), 19041242 (1)
meningioma	0.00	4	11147878 (2), 11745202 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/239 PubMed articles for CAPN1 gene (see all 239 ):

Complete amino acid sequence of the large subunit of the low-Ca2+- requiring form of human Ca2+-activated neutral protease (muCANP) deduced from its cDNA sequence. (PubMed id 3017764)^{2, 3, 4} Aoki K.... Suzuki K. (1986)
Four genes for the calpain family locate on four distinct human chromosomes. (PubMed id 2209092)^{1, 2, 3} Ohno S....Suzuki K. (1990)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
A novel member of the calcium-dependent cysteine protease family. (PubMed id 2400579)^{3, 4} Sorimachi H.... Suzuki K. (1990)
Functional dissection of human protease mu-calpain in cell migration using RNAi. (PubMed id 16697376)^{1, 3} Wu M....Shen S.H. (2006)
mu-Calpain and calpain-3 are not autolyzed with exhaustive exercise in humans. (PubMed id 16107503)^{1, 3} Murphy R.M....Lamb G.D. (2006)
Cleavage of integrin by mu-calpain during hypoxia in human endometrial cells. (PubMed id 15663601)^{1, 3} Aoyama K....Suzumori K. (2004)
Site-directed mutagenesis of alpha II spectrin at codon 1175 modulates its mu-calpain susceptibility. (PubMed id 8993318)^{1, 3} Stabach P.R.... Morrow J.S. (1997)
Platelet sarcoplasmic endoplasmic reticulum Ca2+-ATPase and mu-calpain activity are altered in type 2 diabetes mellitus and restored by rosiglitazone. (PubMed id 18071073)^{1, 3} Randriamboavonjy V....Fleming I. (2008)
The PEST domain of IkappaBalpha is necessary and sufficient for in vitro degradation by mu-calpain. (PubMed id 10521480)^{1, 3} Shumway S.D....Miyamoto S. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 823	HGNC: 1476	AceView: CAPN1	Ensembl:ENSG00000014216	euGenes: HUgn823
ECgene: CAPN1	H-InvDB: CAPN1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
CaBP	http://structbio.vanderbilt.edu/cabp_database/general/prot_pages/calpain.html
Calpains homepage	http://ag.arizona.edu/calpains/
NIEHS-SNPs	http://egp.gs.washington.edu/data/capn1/

Licensable Technologies for CAPN1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CAPN1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CAPN1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CAPN1		Antibodies for CAPN1
	Explore super-pooled esiRNAs		Proteins for CAPN1
	Lentivirus-delivered shRNAs for CAPN1		Small molecules for CAPN1
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CAPN1)
	Search for Antibodies
	Chimera RNAi (CAPN1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for CAPN1 (Calpain 1)

	Recombinant Proteins (Calpain, Calpain 1)
	Antibodies (Calpain, Calpain 1)

Search OriGene for CAPN1

Tocris compounds for CAPN1

	Drugs for CAPN1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CAPN1

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CAPN1 Gene at Home site.
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CAPN1 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for CAPN1

Summaries
for CAPN1

Genomic Location
for CAPN1

Proteins
for CAPN1

Protein Domains/
Families
for CAPN1

Gene Function
for CAPN1

Pathways & Interactions
for CAPN1

Drugs & Compounds
for CAPN1

Transcripts
for CAPN1

Expression
for CAPN1

Orthologs
for CAPN1

Paralogs
for CAPN1

SNPs/Variants
for CAPN1

Disorders & Mutations
for CAPN1

Medical News
for CAPN1

Publications
for CAPN1

Search for CAPN1

Genome Databases showing CAPN1

Other Databases showing CAPN1

Specialized Databases showing CAPN1

Licensable Technologies
for CAPN1

Services
for CAPN1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CAPN1 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor CAPN1

Summariesfor CAPN1

Genomic Locationfor CAPN1

Proteinsfor CAPN1

Protein Domains/Familiesfor CAPN1

Gene Functionfor CAPN1

Pathways & Interactionsfor CAPN1

Drugs & Compoundsfor CAPN1

Transcriptsfor CAPN1

Expression for CAPN1

Orthologsfor CAPN1

Paralogsfor CAPN1

SNPs/Variantsfor CAPN1

Disorders & Mutationsfor CAPN1

Medical Newsfor CAPN1

Publicationsfor CAPN1

Search for CAPN1

Genome Databases showing CAPN1

Other Databases showing CAPN1

Specialized Databases showing CAPN1

Licensable Technologiesfor CAPN1

Servicesfor CAPN1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CAPN1

Summaries
for CAPN1

Genomic Location
for CAPN1

Proteins
for CAPN1

Protein Domains/
Families
for CAPN1

Gene Function
for CAPN1

Pathways & Interactions
for CAPN1

Drugs & Compounds
for CAPN1

Transcripts
for CAPN1

Expression
for CAPN1

Orthologs
for CAPN1

Paralogs
for CAPN1

SNPs/Variants
for CAPN1

Disorders & Mutations
for CAPN1

Medical News
for CAPN1

Publications
for CAPN1

Licensable Technologies
for CAPN1

Services
for CAPN1