Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CAPN1 Gene

protein-coding   GIFtS: 68
GCID: GC11P064950

Calpain 1, (Mu/I) Large Subunit

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Calpain 1, (Mu/I) Large Subunit1 2     CANP2
Calcium-Activated Neutral Proteinase 12 3     CANP12
Calpain Mu-Type2 3     Calpain, Large Polypeptide L12
Calpain-1 Large Subunit2 3     Calpain-1 Catalytic Subunit2
Cell Proliferation-Inducing Gene 30 Protein2 3     Cell Proliferation-Inducing Protein 302
CANPL12 3     micromolar-calpain2
CANP 12 3     muCL2
muCANP2 3     Micromolar-calpain3
EC 3.4.22.523 8     EC 3.4.228

External Ids:    HGNC: 14761   Entrez Gene: 8232   Ensembl: ENSG000000142167   OMIM: 1142205   UniProtKB: P073843   
ORGUL members:         
NONCODE14:n411539      

Export aliases for CAPN1 gene to outside databases

Previous GC identifers: GC11P067465 GC11P066630 GC11P065198 GC11P064724 GC11P064705 GC11P061278


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CAPN1 Gene:
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The
mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes
consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory
subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants
encoding two different isoforms have been found for this gene. (provided by RefSeq, Nov 2010)

GeneCards Summary for CAPN1 Gene: 
CAPN1 (calpain 1, (mu/I) large subunit) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with CAPN1 include meningothelial meningioma, and brain ischemia, and among its related super-pathways are Parkinson's disease and nNOS Signaling in Skeletal Muscle. GO annotations related to this gene include calcium-dependent cysteine-type endopeptidase activity and calcium ion binding. An important paralog of this gene is CAPN6.

UniProtKB/Swiss-Prot: CAN1_HUMAN, P07384
Function: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved
in cytoskeletal remodeling and signal transduction

summary for CAPN1 Gene:
Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals.
This family contains 14 members with mu-calpain (calpain 1) and m-calpain (calpain 2) being the most
well-characterized. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa
regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure. Calpains are regulated
by Ca2+ concentration, phosphorylation, calpastatin and probably by altering their subcellular localization
(limiting access to substrate). These endopeptidases have numerous functions including, but not limited to,
remodeling of cytoskeletal attachments to the plasma membrane during cell fusion and cell motility,
proteolytic modification of molecules in signal transduction pathways, degradation of enzymes controlling
progression through the cell cycle, regulation of gene expression, substrate degradation in some apoptotic
pathways, and an involvement in long-term potentiation. Perturbations in calpain activity have been
associated in pathophysiological processes contributing to type II diabetes (calpain 10), Alzheimer's
disease (calpain 1), gastric cancer (calpain 9) and muscular dystrophy (calpain 3).

Gene Wiki entry for CAPN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CAPN1 gene promoter:
         SREBP-1c   p300   Lmo2   LCR-F1   SREBP-1b   Gfi-1   PPAR-gamma1   SREBP-1a   PPAR-gamma2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCAPN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CAPN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAPN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13

CAPN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAPN1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P064950:  view genomic region     (about GC identifiers)

Start:
64,948,037 bp from pter      End:
64,979,477 bp from pter
Size:
31,441 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CAN1_HUMAN, P07384 (See protein sequence)
Recommended Name: Calpain-1 catalytic subunit  
Size: 714 amino acids; 81890 Da
Cofactor: Binds 4 calcium ions
Subunit: Forms a heterodimer with a small (regulatory) subunit (CAPNS1)
Subcellular location: Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding
2 PDB 3D structures from and Proteopedia for CAPN1:
1ZCM (3D)        2ARY (3D)    
Secondary accessions: Q2TTR0 Q6DHV4

Explore the universe of human proteins at neXtProt for CAPN1: NX_P07384

Explore proteomics data for CAPN1 at MOPED 

Post-translational modifications:

  • UniProtKB: Undergoes calcium-induced successive autoproteolytic cleavages that generate a membrane-bound 78 kDa active form
    and an intracellular 75 kDa active form. Calpastatin reduces with high efficiency the transition from 78 kDa to
    75 kDa calpain forms
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P07384

  • 4/39 DME Specific Peptides for CAPN1 (P07384) (see all 39)
     LRFFSEK  GATRTDI  YEALSGG  LVKGHAY 

    CAPN1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CAPN1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001185797.1  NP_001185798.1  NP_005177.2  

    ENSEMBL proteins: 
     ENSP00000435847   ENSP00000432512   ENSP00000435272   ENSP00000433823   ENSP00000431528  
     ENSP00000431686   ENSP00000434176   ENSP00000279247   ENSP00000436693   ENSP00000431793  
     ENSP00000436002   ENSP00000435092   ENSP00000431172   ENSP00000435198   ENSP00000431984  
     ENSP00000433366  

    Human Recombinant Protein Products for CAPN1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CAPN1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CAPN1
    GenScript Custom Purified and Recombinant Proteins Services for CAPN1
    Novus Biologicals CAPN1 Proteins
    Novus Biologicals CAPN1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CAPN1
    Cloud-Clone Corp. Proteins for CAPN1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IEA--

    CAPN1 for ontologies           About GeneDecksing



    CAPN1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CAPN1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CAPN1  (calpain 1)
    OriGene Antibodies for CAPN1
    OriGene Custom Antibody Services for CAPN1
    GenScript Custom Superior Antibodies Services for CAPN1
    Novus Biologicals CAPN1 Antibodies
    Abcam antibodies for CAPN1
    Cloud-Clone Corp. Antibodies for CAPN1 
    ThermoFisher Antibody for CAPN1
    LSBio Antibodies in human, mouse, rat for CAPN1 

    Assay Products for CAPN1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CAPN1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CAPN1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CAPN1 
    Cloud-Clone Corp. CLIAs for CAPN1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    EFHAND: EF-hand domain containing

    5/8 InterPro protein domains (see all 8):
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom
     IPR001300 Peptidase_C2_calpain_cat
     IPR018247 EF_Hand_1_Ca_BS
     IPR000169 Pept_cys_AS

    Graphical View of Domain Structure for InterPro Entry P07384

    ProtoNet protein and cluster: P07384

    1 Blocks protein domain: IPB001300 Calpain cysteine protease (C2) family signature

    UniProtKB/Swiss-Prot: CAN1_HUMAN, P07384
    Similarity: Belongs to the peptidase C2 family
    Similarity: Contains 1 calpain catalytic domain
    Similarity: Contains 4 EF-hand domains


    CAPN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAN1_HUMAN, P07384
    Function: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved
    in cytoskeletal remodeling and signal transduction
    Catalytic activity: Broad endopeptidase specificity
    Enzyme regulation: Activated by micromolar concentrations of calcium and inhibited by calpastatin

         Genatlas biochemistry entry for CAPN1:
    calpain,large polypeptide L1,calcium dependent neutral cysteine proteinase,papain superfamily,mu type (not mutated
    in MEN1)

         Enzyme Numbers (IUBMB): EC 3.4.22.521 2 EC 3.4.222

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004198calcium-dependent cysteine-type endopeptidase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI19712109
         
    CAPN1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CAPN1:
     Decreased focal adhesion (FA)   Increased HPV18 LCR reporter a  Increased gamma-H2AX phosphory 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Capn1):
     cardiovascular system  cellular  embryogenesis  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  normal 

    CAPN1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Capn1tm1Ahc for CAPN1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CAPN1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CAPN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAPN1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAPN1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAPN1
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CAPN1 (see all 9):
    hsa-miR-3163 hsa-miR-140-5p hsa-miR-22 hsa-miR-4297 hsa-miR-1301 hsa-miR-1205 hsa-miR-124 hsa-miR-1207-3p
    SwitchGear 3'UTR luciferase reporter plasmidCAPN1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CAPN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAPN1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CAPN1
    Sirion Biotech Customized adenovirus for overexpression of CAPN1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CAPN1 (see all 9)
    OriGene ORF clones in mouse, rat for CAPN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CAPN1 (NM_005186)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAPN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPN1
    Sirion Biotech Customized lentivirus for stable overexpression of CAPN1 
                         Customized lentivirus expression plasmids for stable overexpression of CAPN1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CAPN1
    Search LifeMap BioReagents cell lines for CAPN1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPN1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CAPN1 About   (see all 14)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Alzheimer's disease0.46
    Alzheimers Disease0.44
    2DREAM Repression and Dynorphin Expression
    nNOS Signaling in Skeletal Muscle0.37
    Calpain Protease Regulates Cellular Mechanics0.31
    Caspase Cascade0.36
    3Focal Adhesion
    Focal Adhesion0.64
    Integrin-mediated cell adhesion0.38
    4Integrin Pathway
    FAK1 Signaling0.67
    5Rho Family GTPases
    ERK Signaling0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CAPN1 (see all 7)
        Caspase Cascade
    ERK Signaling
    Alzheimers Disease Pathway
    Calpain Protease Regulates Cellular Mechanics
    FAK1 Signaling

    2 Cell Signaling Technology (CST) Pathways for CAPN1
        Neuroscience
    Protein Stability

    1 Tocris Bioscience Pathway for CAPN1
        Apoptosis Pathway

    5 BioSystems Pathways for CAPN1
        Focal Adhesion
    Integrin-mediated cell adhesion
    Alzheimers Disease
    Integrated Pancreatic Cancer Pathway
    Signaling events mediated by PTP1B


    3         Kegg Pathways  (Kegg details for CAPN1):
        Protein processing in endoplasmic reticulum
    Apoptosis
    Alzheimer's disease


    CAPN1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CAPN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/71 Interacting proteins for CAPN1 (P073841, 2, 3 ENSP000002792474) via UniProtKB, MINT, STRING, and/or I2D (see all 71)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAPNS1P046322, 3, ENSP000002465334MINT-7234481 MINT-7234562 MINT-7234580 I2D: score=3 STRING: ENSP00000246533
    PTPN1P180312, 3, ENSP000003606834MINT-6793387 MINT-7234481 MINT-7234562 MINT-7234580 I2D: score=2 STRING: ENSP00000360683
    EZRP153112, ENSP000003389344MINT-8385943 MINT-8385967 STRING: ENSP00000338934
    COL1A1P024523, ENSP000002259644I2D: score=3 STRING: ENSP00000225964
    COL3A1P024613, ENSP000003044084I2D: score=3 STRING: ENSP00000304408
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0008284positive regulation of cell proliferation TAS8702541
    GO:0032801receptor catabolic process IEA--

    CAPN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CAPN1 for compounds           About GeneDecksing

    EMD Millipore small molecules for CAPN1:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for CAPN1

    Compounds for CAPN1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Acetyl-Calpastatin (184-210) (human)Selective calpain inhibitor[123714-50-1]
    MDL 28170 Potent, selective calpain and cathepsin B inhibitor [88191-84-8]
    PD 150606Cell permeable calpain inhibitor[179528-45-1]
    MG 132Proteasome and calpain inhibitor. Inhibits NF-kappaB activation[133407-82-6]
    MG 101Calpain inhibitor; activates p53-dependent apoptosis[110044-82-1]

    1 HMDB Compound for CAPN1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    3 DrugBank Compounds for CAPN1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE-- --target--10592235
    N-[N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-Butyl]-Guanidine-- --target--10592235
    CBZ-LEU-LEU-TYR-CH2F-- --target----

    10/23 Novoseek inferred chemical compound relationships for CAPN1 gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calpeptin 85.5 8 12573450 (1), 18057999 (1), 8032318 (1), 8638921 (1) (see all 5)
    n-acetylleucylleucylnorleucinal 72.7 1 12670502 (1)
    e 64d 67.7 1 11264351 (1)
    cysteine 61.9 15 18501725 (2), 11943592 (1), 18694642 (1), 12072431 (1) (see all 11)
    calcium 55.3 87 16107503 (5), 7961733 (4), 9210524 (3), 15358198 (3) (see all 41)
    lactacystin 40.1 1 12670502 (1)
    ritonavir 35 6 17855594 (2), 15629450 (1), 14555228 (1)
    ionomycin 32.6 4 7982901 (2), 12393869 (1), 16081284 (1)
    phosphatidylserine 25.6 2 7607311 (1)
    mg 132 25.5 1 1734892 (1)

    Search CenterWatch for drugs/clinical trials and news about CAPN1 / CAN1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CAPN1 gene (3 alternative transcripts): 
    NM_001198868.1  NM_001198869.1  NM_005186.3  

    Unigene Cluster for CAPN1:

    Calpain 1, (mu/I) large subunit
    Hs.502842  [show with all ESTs]
    Unigene Representative Sequence: NM_001198868
    18/28 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
    ENST00000528396 ENST00000529133 ENST00000533820(uc009yqd.2) ENST00000527739
    ENST00000526966 ENST00000533129 ENST00000524773(uc001odf.2) ENST00000530442
    ENST00000279247(uc001odg.2 uc010roa.2) ENST00000528739 ENST00000532285
    ENST00000527189 ENST00000527469 ENST00000534373 ENST00000526954 ENST00000531068
    ENST00000527699 ENST00000533909

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAPN1
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CAPN1 (see all 9):
    hsa-miR-3163 hsa-miR-140-5p hsa-miR-22 hsa-miR-4297 hsa-miR-1301 hsa-miR-1205 hsa-miR-124 hsa-miR-1207-3p
    SwitchGear 3'UTR luciferase reporter plasmidCAPN1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CAPN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAPN1
    Clone
    Products:
         
    OriGene clones in human, mouse for CAPN1 (see all 9)
    OriGene ORF clones in mouse, rat for CAPN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): CAPN1 (NM_005186)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAPN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPN1
    Sirion Biotech Customized lentivirus for stable overexpression of CAPN1 
                         Customized lentivirus expression plasmids for stable overexpression of CAPN1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CAPN1
    OriGene qSTAR qPCR primer pairs in human, mouse for CAPN1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CAPN1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAPN1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAPN1

    Additional mRNA sequence: 

    AK022319.1 AK025380.1 AK097277.1 AK301538.1 AK311001.1 AK315556.1 AY550975.1 BC008751.2 
    BC015091.2 BC017200.2 BC075862.1 NR_040008.1 X04366.1 

    24/38 DOTS entries (see all 38):

    DT.447394  DT.97864406  DT.86840162  DT.75199128  DT.100846351  DT.95189131  DT.100846348  DT.100846341 
    DT.95365707  DT.100846346  DT.95341266  DT.95189126  DT.120728821  DT.100846343  DT.100846354  DT.120728803 
    DT.91773350  DT.120728779  DT.120728788  DT.100712092  DT.120728851  DT.95189138  DT.120728832  DT.75199127 

    24/670 AceView cDNA sequences (see all 670):

    BU146807 BQ060759 BG747597 CD515604 AW778834 BM717920 CA432840 BF915559 
    BQ689734 AA394281 CD620043 BU185889 BQ684800 CA748622 BM463453 BQ002160 
    AU130839 AI452945 BG170963 AI955708 BU197119 BQ643043 BM479679 CA391857 

    GeneLoc Exon Structure

    5/23 Alternative Splicing Database (ASD) splice patterns (SP) for CAPN1 (see all 23)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e ^ 12a · 12b · 12c ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                      -     -               
    SP3:                                            -     -     -     -     -     -     -                                                     -     -               
    SP4:              -     -     -     -     -     -     -     -     -     -     -     -                                                     -     -               
    SP5:                                                                                                                                                            

    ExUns: 12d · 12e ^ 13a · 13b ^ 14a · 14b · 14c · 14d ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b · 25c ^ 26 ^
    SP1:                                                                                                                                      -     -               
    SP2:                                            -     -                                                                                                         
    SP3:                                            -     -                                                                                                         
    SP4:                                                                                                                                                            
    SP5:                                            -     -                                   -     -                                                               

    ExUns: 27 ^ 28a · 28b ^ 29 ^ 30a · 30b
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for CAPN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CAPN1 expression in normal human tissues (normalized intensities)      CAPN1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTCGGGAT
    CAPN1 Expression
    About this image


    CAPN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Epidermis (Integumentary System)    fully expand to see all 3 entries
             Spinous Keratinocytes Stratified Epidermis
     
     Esophagus (Gastrointestinal Tract)
             esophageal epithelium   
     
     Lung (Respiratory System)
             bronchoalveolar lavage cells   
     
     Intestine (Gastrointestinal Tract)
             ileum   
     
     Epithelium (Uncategorized)
             esophageal epithelium   

    See CAPN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CAPN1

    SOURCE GeneReport for Unigene cluster: Hs.502842

    UniProtKB/Swiss-Prot: CAN1_HUMAN, P07384
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Arrays including CAPN1: 
              Alzheimer's Disease in human mouse rat
              Necrosis in human mouse rat
              Cell Motility in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CAPN1
    OriGene qSTAR qPCR primer pairs in human, mouse for CAPN1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CAPN1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAPN1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAPN1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CAPN1 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Capn11 , 5 calpain 11, 5 85.97(n)1
    89.34(a)1
      19 (4.34 cM)5
    123331  NM_001110504.11  NP_001103974.11 
     59885465 
    chicken
    (Gallus gallus)
    Aves CAPN11 calpain 1, (mu/I) large subunit 77.92(n)
    82.07(a)
      693249  NM_001044672.1  NP_001038137.1 
    lizard
    (Anolis carolinensis)
    Reptilia CAPN16
    Uncharacterized protein
    85(a)
    1 ↔ 1
    GL343994.1(163047-198614)
    African clawed frog
    (Xenopus laevis)
    Amphibia capn1-prov2 calpain 1, (mu/I) large subunit 76.06(n)    BC044317.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.171162 Danio rerio calpain 1 mRNA, complete cds 77.37(n)    AF282675.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CalpA3 actin cytoskeleton organization and
    biogenesis more
    48(a)
    (best of 3)
      56D5   --
    worm
    (Caenorhabditis elegans)
    Secernentea clp-73   -- 47(a)
    (best of 3)
      IV(1435632-1445971)   --


    ENSEMBL Gene Tree for CAPN1 (if available)
    TreeFam Gene Tree for CAPN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CAPN1 gene
    CAPN62  CAPN82  CAPN142  CAPNS12  CAPN132  CAPN52  CAPN92  CAPN32  
    CAPNS22  CAPN22  CAPN122  CAPN112  CAPN102  
    13 SIMAP similar genes for CAPN1 using alignment to 12 protein entries:     CAN1_HUMAN (see all proteins):
    CAPN2    CAPN8    CAPN11    CAPNS1    CAPN9    CAPNS2
    CAPN3    CAPN14    CAPN12    SRI    CAPN13    CAPN6
    GCA

    CAPN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/735 SNPs in CAPN1 are shown (see all 735)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1889899301,2
    --64946805(+) GTGTAG/TGACAG 1 -- us2k10--------
    rs11959681,2
    C,F,A,H--64946858(+) atggtC/Tgatct 1 -- us2k123Minor allele frequency- T:0.46NS EA NA WA CSA 2521
    rs1920979191,2
    --64947001(+) GAAGTG/TTCTGT 1 -- us2k10--------
    rs1475693161,2
    --64947037(+) AGGCGC/TGGTGG 1 -- us2k10--------
    rs1420586181,2
    C--64947101(+) GTCAGG/TAGTTT 1 -- us2k10--------
    rs1836625041,2
    --64947118(+) AGCTTA/GGCTAA 1 -- us2k10--------
    rs1873930301,2
    --64947125(+) CTAACA/GTGGTG 1 -- us2k10--------
    rs1915206631,2
    --64947196(+) CCCAGC/TTACTG 2 -- us2k10--------
    rs2013060261,2
    C--64947215(+) GAGGC-/AGGAGAAT 2 -- us2k10--------
    rs128003391,2
    C,F,A--64947240(+) ggaggC/Tggagg 2 -- us2k14Minor allele frequency- T:0.38NA 8

    HapMap Linkage Disequilibrium report for CAPN1 (64948037 - 64979477 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CAPN1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509418CNV Insertion20534489
    nsv832190CNV Loss17160897
    nsv897713CNV Loss21882294
    nsv526181CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CAPN1
    DNA2.0 Custom Variant and Variant Library Synthesis for CAPN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 114220    OMIM disorders: --

    20/42 diseases for CAPN1 (see all 42):    About MalaCards
    meningothelial meningioma    brain ischemia    wermer syndrome    gastric cancer
    tauopathy    meningioma    traumatic brain injury    hereditary spastic paraplegia
    alzheimer's disease    congestive heart failure    muscular dystrophy    brain injury
    ischemia    paraplegia    multiple endocrine neoplasia    protein s deficiency
    vaginitis    ichthyosis    neurofibromatosis    chondrosarcoma

    2 diseases from the University of Copenhagen DISEASES database for CAPN1:
    Progressive myoclonus epilepsy     Mucoepidermoid carcinoma

    CAPN1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/11 Novoseek inferred disease relationships for CAPN1 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    brain ischemia 26.8 1 10072294 (1)
    alzheimers disease 5.82 5 8737608 (1), 8622780 (1), 18396356 (1), 19041242 (1)
    associated conditions 0.549 1 7982901 (1)
    carcinoma squamous cell 0 3 12635142 (1), 7982901 (1)
    stroke 0 3 18396356 (1), 19041242 (1)
    meningioma 0 4 11147878 (2), 11745202 (1)
    ischemia 0 2 17514421 (1), 17196166 (1)
    necrosis 0 2 16574073 (1), 17180042 (1)
    breast cancer 0 3 15358198 (1), 12750552 (1), 16081284 (1)
    tumors 0 2 16574073 (1), 17180042 (1)


    Export disorders for CAPN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CAPN1 gene, integrated from 9 sources (see all 329):
    (articles sorted by number of sources associating them with CAPN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete amino acid sequence of the large subunit of the low-Ca2+- requiring form of human Ca2+-activated neutral protease (muCANP) deduced from its cDNA sequence. (PubMed id 3017764)1, 2, 3 Aoki K.... Suzuki K. (1986)
    2. Four genes for the calpain family locate on four distinct human chromosomes. (PubMed id 2209092)1, 3, 9 Ohno S....Suzuki K. (1990)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. A novel member of the calcium-dependent cysteine protease family. (PubMed id 2400579)1, 2 Sorimachi H.... Suzuki K. (1990)
    5. Functional dissection of human protease mu-calpain in cell migration using RNAi. (PubMed id 16697376)1, 9 Wu M....Shen S.H. (2006)
    6. mu-Calpain and calpain-3 are not autolyzed with exhaustive exercise in humans. (PubMed id 16107503)1, 9 Murphy R.M....Lamb G.D. (2006)
    7. Cleavage of integrin by mu-calpain during hypoxia in human endometrial cells. (PubMed id 15663601)1, 9 Aoyama K....Suzumori K. (2004)
    8. Site-directed mutagenesis of alpha II spectrin at codon 1175 modulates its mu-calpain susceptibility. (PubMed id 8993318)1, 9 Stabach P.R.... Morrow J.S. (1997)
    9. Platelet sarcoplasmic endoplasmic reticulum Ca2+-ATPase and mu-calpain activity are altered in type 2 diabetes mellitus and restored by rosiglitazone. (PubMed id 18071073)1, 9 Randriamboavonjy V....Fleming I. (2008)
    10. The PEST domain of IkappaBalpha is necessary and sufficient for in vitro degradation by mu-calpain. (PubMed id 10521480)1, 9 Shumway S.D....Miyamoto S. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 823 HGNC: 1476 AceView: CAPN1 Ensembl:ENSG00000014216 euGenes: HUgn823
    ECgene: CAPN1 Kegg: 823 H-InvDB: CAPN1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CAPN1 Pharmacogenomics, SNPs, Pathways
    CaBPhttp://structbio.vanderbilt.edu/cabp_database/general/prot_pages/calpain.html
    Calpains homepagehttp://ag.arizona.edu/calpains/
    NIEHS-SNPshttp://egp.gs.washington.edu/data/capn1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CAPN1 gene:
    Search GeneIP for patents involving CAPN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore small molecules (inhibitor) for CAPN1
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CAPN1
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CAPN1   OriGene RNAi products in human, mouse, rat for CAPN1  
     OriGene qPCR primer pairs and template standards for CAPN1   OriGene Protein Over-expression Lysate for CAPN1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CAPN1  
     OriGene qSTAR qPCR primer pairs in human, mouse for CAPN1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CAPN1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CAPN1   OriGene Custom Protein Services for CAPN1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CAPN1
     QIAGEN SeqTarget long-range PCR primers for resequencing CAPN1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAPN1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAPN1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAPN1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAPN1
     GenScript Custom Purified and Recombinant Proteins Services for CAPN1 GenScript cDNA clones with any tag delivered in your preferred vector for CAPN1
     GenScript Custom Assay Services for CAPN1 GenScript Custom Superior Antibodies Services for CAPN1
     GenScript Custom overexpressing Cell Line Services for CAPN1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for CAPN1 
    (calpain 1)

     Regulatory tfbs in CAPN1 promoter
     Search Chromatin IP Primers for CAPN1
     RT2 qPCR Primer Assay in human, mouse, rat CAPN1
     Search GNC Networks for CAPN1
     SABiosciences PCR Arrays including human, mouse, rat CAPN1
     Tocris compounds for CAPN1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs for CAPN1
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CAPN1 antibodies
     CAPN1 proteins
     CAPN1 lysates
     Antibodies for CAPN1
     See all of Abcam's Antibodies, Kits and Proteins for CAPN1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CAPN1




     Proteins for CAPN1
     Antibodies for CAPN1
     ELISAs for CAPN1
     CLIAs for CAPN1
     Search LifeMap BioReagents cell lines for CAPN1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPN1
     SwitchGear 3'UTR luciferase reporter plasmids for CAPN1
     SwitchGear Promoter luciferase reporter plasmids for CAPN1
     ThermoFisher Antibody for CAPN1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPN1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CAPN1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CAPN1
    Customized:
     lentivirus for stable overexpression of CAPN1
     lentivirus expression plasmids for stable overexpression of CAPN1
     adenovirus for overexpression of CAPN1
     LSBio Antibodies in human, mouse, rat for CAPN1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CAPN1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4