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Aliases for CAPN1 Gene

Aliases for CAPN1 Gene

  • Calpain 1, (Mu/I) Large Subunit 2 3
  • Cell Proliferation-Inducing Gene 30 Protein 3 4
  • Calcium-Activated Neutral Proteinase 1 3 4
  • Calpain-1 Large Subunit 3 4
  • Micromolar-Calpain 3 4
  • Calpain Mu-Type 3 4
  • EC 3.4.22.52 4 63
  • CANP 1 3 4
  • CANPL1 3 4
  • MuCANP 3 4
  • Cell Proliferation-Inducing Protein 30 3
  • Calpain, Large Polypeptide L1 3
  • Calpain-1 Catalytic Subunit 3
  • EC 3.4.22 63
  • CANP1 3
  • CANP 3
  • MuCL 3

External Ids for CAPN1 Gene

Previous GeneCards Identifiers for CAPN1 Gene

  • GC11P067465
  • GC11P066630
  • GC11P064724
  • GC11P064705
  • GC11P064950
  • GC11P061278

Summaries for CAPN1 Gene

Entrez Gene Summary for CAPN1 Gene

  • The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for CAPN1 Gene

CAPN1 (Calpain 1, (Mu/I) Large Subunit) is a Protein Coding gene. Diseases associated with CAPN1 include meningothelial meningioma. Among its related pathways are ERK Signaling and Apoptosis Pathway. GO annotations related to this gene include calcium ion binding and calcium-dependent cysteine-type endopeptidase activity. An important paralog of this gene is CAPN9.

UniProtKB/Swiss-Prot for CAPN1 Gene

  • Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction

Tocris Summary for CAPN1 Gene

  • Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. This family contains 14 members with mu-calpain (calpain 1) and m-calpain (calpain 2) being the most well-characterized. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure. Calpains are regulated by Ca2+ concentration, phosphorylation, calpastatin and probably by altering their subcellular localization (limiting access to substrate). These endopeptidases have numerous functions including, but not limited to, remodeling of cytoskeletal attachments to the plasma membrane during cell fusion and cell motility, proteolytic modification of molecules in signal transduction pathways, degradation of enzymes controlling progression through the cell cycle, regulation of gene expression, substrate degradation in some apoptotic pathways, and an involvement in long-term potentiation. Perturbations in calpain activity have been associated in pathophysiological processes contributing to type II diabetes (calpain 10), Alzheimer's disease (calpain 1), gastric cancer (calpain 9) and muscular dystrophy (calpain 3).

Gene Wiki entry for CAPN1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPN1 Gene

Genomics for CAPN1 Gene

Regulatory Elements for CAPN1 Gene

Genomic Location for CAPN1 Gene

Start:
65,180,566 bp from pter
End:
65,212,006 bp from pter
Size:
31,441 bases
Orientation:
Plus strand

Genomic View for CAPN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAPN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPN1 Gene

Proteins for CAPN1 Gene

  • Protein details for CAPN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07384-CAN1_HUMAN
    Recommended name:
    Calpain-1 catalytic subunit
    Protein Accession:
    P07384
    Secondary Accessions:
    • Q2TTR0
    • Q6DHV4

    Protein attributes for CAPN1 Gene

    Size:
    714 amino acids
    Molecular mass:
    81890 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 4 Ca(2+) ions.;
    Quaternary structure:
    • Forms a heterodimer with a small (regulatory) subunit (CAPNS1)

    Three dimensional structures from OCA and Proteopedia for CAPN1 Gene

neXtProt entry for CAPN1 Gene

Proteomics data for CAPN1 Gene at MOPED

Post-translational modifications for CAPN1 Gene

  • Undergoes calcium-induced successive autoproteolytic cleavages that generate a membrane-bound 78 kDa active form and an intracellular 75 kDa active form. Calpastatin reduces with high efficiency the transition from 78 kDa to 75 kDa calpain forms
  • Ubiquitination at Lys20, Lys365, Lys398, Lys461, and Lys583
  • Modification sites at PhosphoSitePlus

Domains for CAPN1 Gene

Gene Families for CAPN1 Gene

HGNC:
  • EFHAND :EF-hand domain containing

Suggested Antigen Peptide Sequences for CAPN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P07384

UniProtKB/Swiss-Prot:

CAN1_HUMAN :
  • P07384
Domain:
  • Contains 1 calpain catalytic domain.
  • Contains 4 EF-hand domains.
Family:
  • Belongs to the peptidase C2 family.
genes like me logo Genes that share domains with CAPN1: view

Function for CAPN1 Gene

Molecular function for CAPN1 Gene

GENATLAS Biochemistry: calpain,large polypeptide L1,calcium dependent neutral cysteine proteinase,papain superfamily,mu type (not mutated in MEN1)
UniProtKB/Swiss-Prot CatalyticActivity: Broad endopeptidase specificity
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by micromolar concentrations of calcium and inhibited by calpastatin
UniProtKB/Swiss-Prot Function: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction

Enzyme Numbers (IUBMB) for CAPN1 Gene

Gene Ontology (GO) - Molecular Function for CAPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004198 calcium-dependent cysteine-type endopeptidase activity ISS --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 19712109
genes like me logo Genes that share ontologies with CAPN1: view
genes like me logo Genes that share phenotypes with CAPN1: view

Animal Models for CAPN1 Gene

MGI Knock Outs for CAPN1:

miRNA for CAPN1 Gene

miRTarBase miRNAs that target CAPN1

No data available for Transcription Factor Targeting and HOMER Transcription for CAPN1 Gene

Localization for CAPN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPN1 Gene

Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAPN1 Gene COMPARTMENTS Subcellular localization image for CAPN1 gene
Compartment Confidence
plasma membrane 5
cytosol 3
cytoskeleton 2
nucleus 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CAPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IDA 12150984
GO:0005886 plasma membrane IDA 12150984
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with CAPN1: view

Pathways for CAPN1 Gene

genes like me logo Genes that share pathways with CAPN1: view

Gene Ontology (GO) - Biological Process for CAPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis ISS --
GO:0008284 positive regulation of cell proliferation TAS 8702541
GO:0022617 extracellular matrix disassembly TAS --
GO:0030198 extracellular matrix organization TAS --
GO:0032801 receptor catabolic process IEA --
genes like me logo Genes that share ontologies with CAPN1: view

Compounds for CAPN1 Gene

(9) ApexBio Compounds for CAPN1 Gene

Compound Action Cas Number
Acetyl-Calpastatin (184-210) (human) Selective calpain inhibitor. [123714-50-1]
Calpain Inhibitor I, ALLN A cell-permeable inhibitor of calpain I, calpain II, cathepsin B, and cathepsin L. [110044-82-1]
Calpain Inhibitor II, ALLM A cell-permeable inhibitor of calpain 1 and calpain 2. [136632-32-1]
Calpeptin Potent cathepsin L inhibitor [117591-20-5]
E-64 Irriversible cysteine protease inhibitor [66701-25-5]
MDL 28170 Potent, selective inhibitor of calpain and cathepsin B. [88191-84-8]
MG-132 Proteasome and calpain inhibitor. [133407-82-6]
PD 150606 Selective, cell-permeable non-peptide calpain inhibitor. [179528-45-1]
Z-FA-FMK An inhibitor of cysteine proteases, such as cathepsin B.

(4) Tocris Compounds for CAPN1 Gene

Compound Action Cas Number
MDL 28170 Potent, selective calpain and cathepsin B inhibitor [88191-84-8]
MG 101 Calpain inhibitor; activates p53-dependent apoptosis [110044-82-1]
MG 132 Proteasome and calpain inhibitor. Inhibits NF-kappaB activation [133407-82-6]
PD 150606 Cell permeable calpain inhibitor [179528-45-1]

(1) HMDB Compounds for CAPN1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(23) Novoseek inferred chemical compound relationships for CAPN1 Gene

Compound -log(P) Hits PubMed IDs
calpeptin 85.5 5
n-acetylleucylleucylnorleucinal 72.7 1
e 64d 67.7 1
cysteine 61.9 12
calcium 55.3 66
genes like me logo Genes that share compounds with CAPN1: view

Transcripts for CAPN1 Gene

Unigene Clusters for CAPN1 Gene

Calpain 1, (mu/I) large subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAPN1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e ^ 12a · 12b · 12c ·
SP1:
SP2: - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5:
SP6: - - - - - - - - - - -
SP7: - -
SP8: - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - -
SP11:
SP12: - - - - - - - -
SP13: - - - -
SP14:
SP15: - - - -
SP16: - - - - - - - - - -
SP17: - - - - - - - - -
SP18:
SP19:
SP20:
SP21: - - - - - -
SP22: -
SP23:

ExUns: 12d · 12e ^ 13a · 13b ^ 14a · 14b · 14c · 14d ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b · 25c ^ 26 ^
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5: - - - -
SP6:
SP7: - - - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - -
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:

ExUns: 27 ^ 28a · 28b ^ 29 ^ 30a · 30b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:

Relevant External Links for CAPN1 Gene

GeneLoc Exon Structure for
CAPN1
ECgene alternative splicing isoforms for
CAPN1

Expression for CAPN1 Gene

mRNA expression in normal human tissues for CAPN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAPN1 Gene

This gene is overexpressed in Esophagus - Mucosa (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAPN1 Gene

SOURCE GeneReport for Unigene cluster for CAPN1 Gene Hs.502842

mRNA Expression by UniProt/SwissProt for CAPN1 Gene

P07384-CAN1_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with CAPN1: view

Orthologs for CAPN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAPN1 35
  • 99.3 (n)
  • 99.72 (a)
CAPN1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CAPN1 35
  • 90.9 (n)
  • 94.82 (a)
CAPN1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAPN1 35
  • 91.75 (n)
  • 97.05 (a)
CAPN1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Capn1 35
  • 85.97 (n)
  • 89.34 (a)
Capn1 16
Capn1 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CAPN1 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAPN1 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Capn1 35
  • 85.74 (n)
  • 89.34 (a)
chicken
(Gallus gallus)
Aves CAPN1 35
  • 77.92 (n)
  • 82.07 (a)
CAPN1 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAPN1 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia capn1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia capn1 35
  • 69.61 (n)
  • 76.86 (a)
zebrafish
(Danio rerio)
Actinopterygii CAPN1 (1 of 2) 36
  • 71 (a)
OneToMany
CAPN1 (2 of 2) 36
  • 66 (a)
OneToMany
Dr.17116 35
zgc:55262 35
  • 68.04 (n)
  • 70.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CalpA 37
  • 48 (a)
CalpB 37
  • 44 (a)
CalpC 37
  • 28 (a)
worm
(Caenorhabditis elegans)
Secernentea clp-7 37
  • 47 (a)
clp-6 37
  • 43 (a)
clp-3 37
  • 37 (a)
Species with no ortholog for CAPN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAPN1 Gene

ENSEMBL:
Gene Tree for CAPN1 (if available)
TreeFam:
Gene Tree for CAPN1 (if available)

Paralogs for CAPN1 Gene

genes like me logo Genes that share paralogs with CAPN1: view

Variants for CAPN1 Gene

Sequence variations from dbSNP and Humsavar for CAPN1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs17583 -- 65,183,499(+) GCCAT(C/T)GCCTC reference, synonymous-codon, nc-transcript-variant
rs542380 -- 65,210,466(+) CCCCA(A/G)CTGCC intron-variant
rs552403 -- 65,202,952(+) gccta(C/T)tggga intron-variant
rs580734 -- 65,203,772(-) tggca(C/G)tttct intron-variant
rs588450 -- 65,202,442(+) tattt(A/G)tttgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAPN1 Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV Gain 19592680
nsv897713 CNV Loss 21882294
nsv509418 CNV Insertion 20534489
nsv832190 CNV Loss 17160897

Relevant External Links for CAPN1 Gene

HapMap Linkage Disequilibrium report
CAPN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPN1 Gene

Disorders for CAPN1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CAPN1 Gene including...

Search for CAPN1 Gene in MalaCards »

(2) University of Copenhagen DISEASES for CAPN1 Gene

(11) Novoseek inferred disease relationships for CAPN1 Gene

Disease -log(P) Hits PubMed IDs
brain ischemia 26.8 1
alzheimers disease 5.82 4
associated conditions 0.549 1
carcinoma squamous cell 0 2
stroke 0 2
genes like me logo Genes that share disorders with CAPN1: view

No data available for UniProtKB/Swiss-Prot for CAPN1 Gene

Publications for CAPN1 Gene

  1. Complete amino acid sequence of the large subunit of the low-Ca2+- requiring form of human Ca2+-activated neutral protease (muCANP) deduced from its cDNA sequence. (PMID: 3017764) Aoki K. … Suzuki K. (FEBS Lett. 1986) 2 3 4
  2. The role of calpain in the proteolytic cleavage of E-cadherin in prostate and mammary epithelial cells. (PMID: 12393869) Rios-Doria J. … Day M.L. (J. Biol. Chem. 2003) 3 23
  3. Mu-calpain is functionally required for alpha-processing of Alzheimer's beta-amyloid precursor protein. (PMID: 15809056) Chen M. … Fernandez H.L. (Biochem. Biophys. Res. Commun. 2005) 3 23
  4. mu-Calpain and calpain-3 are not autolyzed with exhaustive exercise in humans. (PMID: 16107503) Murphy R.M. … Lamb G.D. (Am. J. Physiol., Cell Physiol. 2006) 3 23
  5. Functional dissection of human protease mu-calpain in cell migration using RNAi. (PMID: 16697376) Wu M. … Shen S.H. (FEBS Lett. 2006) 3 23

Products for CAPN1 Gene

  • Addgene plasmids for CAPN1

Sources for CAPN1 Gene

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