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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CAPN1 Gene

protein-coding GIFtS: 67
GCID: GC11P064950

calpain 1, (mu/I) large subunit

Explore 46 diseases affiliated with
CAPN1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Calpain 1, (Mu/I) Large Subunit¹ ²		CANP 1² ³
CANPL1¹ ² ³		EC 3.4.22.52³ ⁸
MuCANP¹		CANP1²
CANP¹ ²		Calpain, Large Polypeptide L1²
MuCL¹		Calpain-1 Catalytic Subunit²
Calcium-Activated Neutral Proteinase 1² ³		Cell Proliferation-Inducing Protein 30²
Calpain Mu-Type² ³		Micromolar-Calpain¹
Calpain-1 Large Subunit² ³		Micromolar-Calpain¹
Cell Proliferation-Inducing Gene 30 Protein² ³		EC 3.4.22⁸

External Ids:	HGNC: 1476¹	Entrez Gene: 823²	Ensembl: ENSG00000014216⁷	OMIM: 114220⁵	UniProtKB: P07384³

ORGUL members:
	NONCODE:n411539

Export aliases for CAPN1 gene to outside databases

Previous GC identifers: GC11P067465 GC11P066630 GC11P065198 GC11P064724 GC11P064705 GC11P061278

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CAPN1:

The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian

calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of

heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene

encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different

isoforms have been found for this gene. (provided by RefSeq, Nov 2010)

UniProtKB/Swiss-Prot: CAN1_HUMAN, P07384

Function: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in

cytoskeletal remodeling and signal transduction

summary for CAPN1:

Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals.

This family contains 14 members with mu-calpain (calpain 1) and m-calpain (calpain 2) being the most

well-characterized. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa

regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure. Calpains are regulated

by Ca2+ concentration, phosphorylation, calpastatin and probably by altering their subcellular localization

(limiting access to substrate). These endopeptidases have numerous functions including, but not limited to,

remodeling of cytoskeletal attachments to the plasma membrane during cell fusion and cell motility,

proteolytic modification of molecules in signal transduction pathways, degradation of enzymes controlling

progression through the cell cycle, regulation of gene expression, substrate degradation in some apoptotic

pathways, and an involvement in long-term potentiation. Perturbations in calpain activity have been

associated in pathophysiological processes contributing to type II diabetes (calpain 10), Alzheimer's

disease (calpain 1), gastric cancer (calpain 9) and muscular dystrophy (calpain 3).

Gene Wiki entry for CAPN1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CAPN1 gene promoter:
SREBP-1c p300 Lmo2 LCR-F1 SREBP-1b Gfi-1 PPAR-gamma1 SREBP-1a PPAR-gamma2 ITF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CAPN1 promoter sequence

Search SABiosciences Chromatin IP Primers for CAPN1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAPN1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13

CAPN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAPN1 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P064950: view genomic region (about GC identifiers)

Start:	64,948,037 bp from pter	End:	64,979,477 bp from pter
Size:	31,441 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CAN1_HUMAN, P07384 (See protein sequence)

Recommended Name: Calpain-1 catalytic subunit

Size: 714 amino acids; 81890 Da

Cofactor: Binds 4 calcium ions

Subunit: Forms a heterodimer with a small (regulatory) subunit (CAPNS1)

Subcellular location: Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding

2 PDB 3D structures from and Proteopedia for CAPN1:

1ZCM (3D)

2ARY (3D)

Secondary accessions: Q2TTR0 Q6DHV4

Explore the universe of human proteins at neXtProt for CAPN1: NX_P07384

Post-translational modifications:

Undergoes calcium-induced successive autoproteolytic cleavages that generate a membrane-bound 78 kDa active form and an

intracellular 75 kDa active form. Calpastatin reduces with high efficiency the transition from 78 kDa to 75 kDa

calpain forms¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P07384

4/39 DME Specific Peptides for CAPN1 (P07384) (see all 39)

LRFFSEK

GATRTDI

YEALSGG

LVKGHAY

CAPN1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001185797.1 NP_001185798.1 NP_005177.2

ENSEMBL proteins:

ENSP00000435847 ENSP00000432512 ENSP00000435272 ENSP00000431341 ENSP00000433823

ENSP00000431528 ENSP00000431686 ENSP00000434176 ENSP00000279247 ENSP00000436693

ENSP00000431793 ENSP00000436002 ENSP00000435092 ENSP00000431172 ENSP00000435198

ENSP00000431984 ENSP00000433366

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: CAPN1 OriGene Custom Protein Services for CAPN1
	GenScript Custom Purified and Recombinant Proteins Services for CAPN1
	Novus Biologicals CAPN1 Proteins Novus Biologicals CAPN1 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CAPN1
	Uscn Proteins for CAPN1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005626	insoluble fraction	--	--
GO:0005737	cytoplasm	IDA	--
GO:0005886	plasma membrane	IEA	--

CAPN1 for ontologies About GeneDecksing

CAPN1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CAPN1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for CAPN1 (calpain 1)
	OriGene Antibodies: CAPN1 OriGene Custom Antibody Services for CAPN1
	GenScript Custom Superior Antibodies Services for CAPN1
	Novus Biologicals CAPN1 Antibodies
	Abcam antibodies for CAPN1
	Uscn Antibodies for CAPN1
	ThermoFisher Antibody for CAPN1

Assay Products for CAPN1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CAPN1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CAPN1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CAPN1 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR011992 EF-hand-like_dom

IPR002048 EF_hand_Ca-bd

IPR001300 Peptidase_C2_calpain_cat

IPR018247 EF_Hand_1_Ca_BS

IPR000169 Pept_cys_AS

Graphical View of Domain Structure for InterPro Entry P07384

ProtoNet protein and cluster: P07384

1 Blocks protein family: IPB001300 Calpain cysteine protease (C2) family signature

UniProtKB/Swiss-Prot: CAN1_HUMAN, P07384

Similarity: Belongs to the peptidase C2 family

Similarity: Contains 1 calpain catalytic domain

Similarity: Contains 4 EF-hand domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CAN1_HUMAN, P07384

Function: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in

cytoskeletal remodeling and signal transduction

Catalytic activity: Broad endopeptidase specificity

Enzyme regulation: Activated by micromolar concentrations of calcium and inhibited by calpastatin

Genatlas biochemistry entry for CAPN1:

calpain,large polypeptide L1,calcium dependent neutral cysteine proteinase,papain superfamily,mu type (not mutated in

MEN1)

Enzyme Numbers (IUBMB): EC 3.4.22.52¹ ² EC 3.4.22²

miRNA Products:		OriGene 3'-UTR Clone: CAPN1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAPN1
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CAPN1 (see all 9):
		hsa-miR-3163 hsa-miR-140-5p hsa-miR-22 hsa-miR-4297 hsa-miR-1301 hsa-miR-1205 hsa-miR-124 hsa-miR-1207-3p

		SwitchGear 3'UTR luciferase reporter plasmid: CAPN1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAPN1 (see all 7) OriGene shRNA RFP: CAPN1 OriGene siRNA: CAPN1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAPN1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CAPN1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAPN1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAPN1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): CAPN1 (NM_005186)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAPN1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPN1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CAPN1
		Search LifeMap BioReagents cell lines for CAPN1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPN1

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	IEA	--
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	--
GO:0008092	cytoskeletal protein binding	--	--

CAPN1 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for CAPN1:

Decreased focal adhesion (FA)

Increased HPV18 LCR reporter a

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-out Capn1^tm1Ahc for CAPN1
8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Capn1):

cardiovascular system	cellular	embryogenesis	hematopoietic system	homeostasis/metabolism
immune system	mortality/aging	normal

CAPN1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

DREAM Repression and Dynorphin Expression

	nNOS Signaling in Skeletal Muscle	0.37			Calpain Protease Regulates Cellular Mechanics	0.22
	Caspase Cascade	0.24

Integrated Pancreatic Cancer Pathway

Integrated Pancreatic Cancer Pathway

1.00

Integrated Pancreatic Cancer Pathway

0.99

Focal Adhesion

Focal Adhesion

1.00

Integrin-mediated cell adhesion

0.38

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

Alzheimer's disease

0.43

Alzheimers Disease

0.00

Protein Stability

Protein Stability

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CAPN1 (see all 7)

	Caspase Cascade
	ERK Signaling
	Alzheimers Disease Pathway
	Calpain Protease Regulates Cellular Mechanics
	FAK1 Signaling

2 Cell Signaling Technology (CST) Pathways for CAPN1

	Neuroscience
	Protein Stability

1 Tocris Bioscience Pathway for CAPN1

Apoptosis Pathway

5/6 BioSystems Pathways for CAPN1 (see all 6)

	Integrin-mediated cell adhesion
	Focal Adhesion
	Integrated Pancreatic Cancer Pathway
	Alzheimers Disease
	Integrated Pancreatic Cancer Pathway

3 Kegg Pathways (Kegg details for CAPN1):

	Protein processing in endoplasmic reticulum
	Apoptosis
	Alzheimer's disease

CAPN1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CAPN1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/70 Interacting proteins for CAPN1 (P07384^{1, 2, 3} ENSP00000279247⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 70)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CAPNS1	P04632²^,³, ENSP00000246533⁴	MINT-7234481 MINT-7234562 MINT-7234580 I2D: score=3 STRING: ENSP00000246533
PTPN1	P18031²^,³, ENSP00000360683⁴	MINT-6793387 MINT-7234481 MINT-7234562 MINT-7234580 I2D: score=2 STRING: ENSP00000360683
EZR	P15311², ENSP00000338934⁴	MINT-8385943 MINT-8385967 STRING: ENSP00000338934
COL1A1	P02452³, ENSP00000225964⁴	I2D: score=3 STRING: ENSP00000225964
COL3A1	P02461³, ENSP00000304408⁴	I2D: score=3 STRING: ENSP00000304408

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--
GO:0008284	positive regulation of cell proliferation	TAS	8702541
GO:0016540	protein autoprocessing	--	--
GO:0032801	receptor catabolic process	IEA	--

CAPN1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CAPN1 for compounds About GeneDecksing

EMD Millipore small molecules for CAPN1:
Small Molecule - inhibitor

Enzo Life Sciences drugs & compounds for CAPN1

Compounds for CAPN1 available from Tocris Bioscience About this table

Compound	Action	CAS #
Calpeptin	Calpain and cathepsin L inhibitor	[117591-20-5]
Acetyl-Calpastatin (184-210) (human)	Selective calpain inhibitor	[123714-50-1]
MDL 28170	Potent, selective calpain and cathepsin B inhibitor	[88191-84-8]
MG 132	Proteasome and calpain inhibitor. Inhibits NF-kappaB activation	[133407-82-6]
MG 101	Calpain inhibitor; activates p53-dependent apoptosis	[110044-82-1]

1 HMDB Compound for CAPN1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

3 DrugBank Compounds for CAPN1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
(2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE	--	--	target	--	10592235
N-[N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-Butyl]-Guanidine	--	--	target	--	10592235
CBZ-LEU-LEU-TYR-CH2F	--	--	target	--	--

10/23 Novoseek chemical compound relationships for CAPN1 gene (see all 23) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
calpeptin	85.5	8	12573450 (1), 18057999 (1), 8032318 (1), 8638921 (1) (see all 5)
n-acetylleucylleucylnorleucinal	72.7	1	12670502 (1)
e 64d	67.7	1	11264351 (1)
cysteine	61.9	15	18501725 (2), 11943592 (1), 18694642 (1), 12072431 (1) (see all 11)
calcium	55.3	87	16107503 (5), 7961733 (4), 9210524 (3), 15358198 (3) (see all 41)
lactacystin	40.1	1	12670502 (1)
ritonavir	35	6	17855594 (2), 15629450 (1), 14555228 (1)
ionomycin	32.6	4	7982901 (2), 12393869 (1), 16081284 (1)
phosphatidylserine	25.6	2	7607311 (1)
mg 132	25.5	1	1734892 (1)

Search CenterWatch for drugs/clinical trials and news about CAPN1 / CAN1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CAPN1 gene (3 alternative transcripts):

NM_001198868.1 NM_001198869.1 NM_005186.3

Unigene Cluster for CAPN1:

Calpain 1, (mu/I) large subunit

Hs.502842 [show with all ESTs]

Unigene Representative Sequence: NM_001198868

18/29 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29):

ENST00000528396 ENST00000529133 ENST00000533820(uc009yqd.2) ENST00000530571

ENST00000527739 ENST00000526966 ENST00000533129 ENST00000524773(uc001odf.2)

ENST00000530442 ENST00000279247(uc001odg.2 uc010roa.2) ENST00000528739

ENST00000532285 ENST00000527189 ENST00000527469 ENST00000534373 ENST00000526954

ENST00000531068 ENST00000527699

miRNA Products:		OriGene 3'-UTR Clone: CAPN1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAPN1
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CAPN1 (see all 9):
		hsa-miR-3163 hsa-miR-140-5p hsa-miR-22 hsa-miR-4297 hsa-miR-1301 hsa-miR-1205 hsa-miR-124 hsa-miR-1207-3p

		SwitchGear 3'UTR luciferase reporter plasmid: CAPN1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAPN1 (see all 7) OriGene shRNA RFP: CAPN1 OriGene siRNA: CAPN1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAPN1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAPN1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAPN1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): CAPN1 (NM_005186)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAPN1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAPN1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CAPN1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CAPN1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAPN1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAPN1

Additional cDNA sequence:

AK022319.1 AK025380.1 AK097277.1 AK301538.1 AK311001.1 AK315556.1 AY550975.1 BC008751.2

BC015091.2 BC017200.2 BC075862.1 NR_040008.1 X04366.1

24/38 DOTS entries (see all 38):

DT.447394 DT.97864406 DT.86840162 DT.75199128 DT.100846351 DT.95189131 DT.100846348 DT.100846341

DT.95365707 DT.100846346 DT.95341266 DT.95189126 DT.120728821 DT.100846343 DT.100846354 DT.120728803

DT.91773350 DT.120728779 DT.120728788 DT.100712092 DT.120728851 DT.95189138 DT.120728832 DT.75199127

24/670 AceView cDNA sequences (see all 670):

AI452945 BQ063309 AW300716 BQ684800 AI610224 AI955708 BQ937978 BI820433

CD515604 AI936036 AK097277 AW778834 BQ690547 AU130911 CA421990 BU197119

BE907919 BI769828 BU849722 BG260192 AW732358 BQ060759 CA489527 BF725827

GeneLoc Exon Structure

5/23 Alternative Splicing Database (ASD) splice patterns (SP) for CAPN1 (see all 23) About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	·	7d	·	7e	·	7f	^	8	^	9	^	10a	·	10b	^	11a	·	11b	·	11c	·	11d	·	11e	^	12a	·	12b	·	12c	·
SP1:
SP2:																																													-		-
SP3:															-		-		-		-		-		-		-																		-		-
SP4:					-		-		-		-		-		-		-		-		-		-		-		-																		-		-
SP5:

ExUns:	12d	·	12e	^	13a	·	13b	^	14a	·	14b	·	14c	·	14d	^	15a	·	15b	·	15c	^	16	^	17a	·	17b	^	18	^	19	^	20a	·	20b	^	21	^	22	^	23	^	24	^	25a	·	25b	·	25c	^	26	^
SP1:																																													-		-
SP2:															-		-
SP3:															-		-
SP4:
SP5:															-		-												-		-

ExUns:	27	^	28a	·	28b	^	29	^	30a	·	30b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for CAPN1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CAPN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCTCGGGAT

About this image

CAPN1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Mandibular Process

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CAPN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CAPN1

SOURCE GeneReport for Unigene cluster: Hs.502842

UniProtKB/Swiss-Prot: CAN1_HUMAN, P07384

Tissue specificity: Ubiquitous

SABiosciences Expression via Pathway-Focused PCR Arrays including CAPN1:

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAPN1 gene from 8/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CAPN1¹	calpain 1, (mu/I) large subunit	77.92(n) 82.07(a)		693249 NM_001044672.1 NP_001038137.1
lizard (Anolis carolinensis)	Reptilia	CAPN1⁶	--	85(a)	1 ↔ 1	GL343994.1(165055-186044)
African clawed frog (Xenopus laevis)	Amphibia	capn1-prov²	calpain 1, (mu/I) large subunit	76.06(n)		BC044317.1
zebrafish (Danio rerio)	Actinopterygii	Dr.17116²	Danio rerio calpain 1 mRNA, complete cds	77.37(n)		AF282675.1
fruit fly (Drosophila melanogaster)	Insecta	CalpA³	actin cytoskeleton organization and biogenesis more	48(a) (best of 3)		56D5 --
worm (Caenorhabditis elegans)	Secernentea	clp-7³	--	47(a) (best of 3)		IV(1435632-1445971) --
thale cress (Arabidopsis thaliana)	eudicotyledons	ATDEK1⁶	calpain-type cysteine protease	6(a)	1 → many	1(20653820-20665095)
rice (Oryza sativa)	Liliopsida	--	calpain, putative, expressed	6(a)	1 → many	2(29335385-29352022)

ENSEMBL Gene Tree for CAPN1 (if available)
TreeFam Gene Tree for CAPN1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CAPN1 gene

CAPN6² CAPN8² CAPN14² CAPN13² CAPN5² CAPN9² CAPN3² CAPN2²

CAPN7² CAPN12² SOLH² CAPN11² CAPN10²

14 SIMAP similar genes for CAPN1 using alignment to 12 protein entries: CAN1_HUMAN (see all proteins):

CAPN2 CAPN8 CAPN11 CAPNS1 CAPN9 CAPNS2

CAPN3 CAPN14 CAPN12 SRI CAPN13 CAPN6

GCA CAPN5

CAPN1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs184054057^1,2	C,	--	61274575(+)	`ACAAAA/TGTTTT`	1	--	nc-transcript-variant		0	--	--	--	--
rs112366910^1,2	C,	--	61275642(+)	`NNNNAC/TTTCTT`	1	--	nc-transcript-variant		2		CSA WA	120
rs17880457^1,2	C,F,	--	61276352(+)	`CCGCGG/ATGCCC`	1	--	us2k¹		1		NS	132
rs12419664^1,2	C,F,H,	--	61276931(+)	`CGAGCC/TTGCTG`	1	--	us2k¹		5		NA EA	246
rs17883654^1,2	C	--	61277075(+)	`TGTGTC/TCCACC`	1	--	us2k¹		3		NS NA	166
rs17883382^1,2	C,	--	61277224(+)	`TCCTGG/CATTCA`	1	--	us2k¹		2		NS WA	292
rs17883146^1,2	C	--	61277240(+)	`AGCACC/TGGGAG`	1	--	us2k¹		3		NS NA	178
rs75873264^1,2		--	61278026(+)	`CGCTGC/GGGCTG`	1	--	us2k¹		0	--	--	--	--
rs3832790^1,2	C,F,	--	61282127(-)	`TGCAGG/-AGGGG`	1	--	int¹ trp³		4		NS NA	178
rs188989930^1,2		--	64946805(+)	`GTGTAG/TGACAG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CAPN1 (64948037 - 64979477 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CAPN1: --

SABiosciences Cancer Mutation PCR Assays

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DNA2.0 Custom Variant and Variant Library Synthesis for CAPN1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CAPN1 for disorders           About GeneDecksing

OMIM gene information: 114220    OMIM disorders: --

20/46 diseases for CAPN1 (see all 46):    About MalaCards

alzheimer's disease gastric cancer meningothelial meningioma spastic paraplegia

hereditary spastic paraplegia traumatic brain injury muscular dystrophy type 2 diabetes mellitus

multiple endocrine neoplasia congestive heart failure brain injury paraplegia

brain ischemia atrial fibrillation wermer syndrome diabetes mellitus

spasticity basal cell carcinoma fanconi's anemia ischemia

10/11 Novoseek disease relationships for CAPN1 gene (see all 11) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
brain ischemia	26.8	1	10072294 (1)
alzheimers disease	5.82	5	8737608 (1), 8622780 (1), 18396356 (1), 19041242 (1)
associated conditions	0.549	1	7982901 (1)
carcinoma squamous cell	0	3	12635142 (1), 7982901 (1)
stroke	0	3	18396356 (1), 19041242 (1)
meningioma	0	4	11147878 (2), 11745202 (1)
ischemia	0	2	17514421 (1), 17196166 (1)
necrosis	0	2	16574073 (1), 17180042 (1)
breast cancer	0	3	15358198 (1), 12750552 (1), 16081284 (1)
tumors	0	2	16574073 (1), 17180042 (1)

Export disorders for CAPN1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CAPN1 gene, integrated from 9 sources (see all 316):
(articles sorted by number of sources associating them with CAPN1)

Utopia: connect your pdf to the dynamic
world of online information

Complete amino acid sequence of the large subunit of the low-Ca2+- requiring form of human Ca2+-activated neutral protease (muCANP) deduced from its cDNA sequence. (PubMed id 3017764)^{1, 2, 3} Aoki K.... Suzuki K. (1986)
Four genes for the calpain family locate on four distinct human chromosomes. (PubMed id 2209092)^{1, 3, 9} Ohno S....Suzuki K. (1990)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A novel member of the calcium-dependent cysteine protease family. (PubMed id 2400579)^{1, 2} Sorimachi H.... Suzuki K. (1990)
Functional dissection of human protease mu-calpain in cell migration using RNAi. (PubMed id 16697376)^{1, 9} Wu M....Shen S.H. (2006)
mu-Calpain and calpain-3 are not autolyzed with exhaustive exercise in humans. (PubMed id 16107503)^{1, 9} Murphy R.M....Lamb G.D. (2006)
Cleavage of integrin by mu-calpain during hypoxia in human endometrial cells. (PubMed id 15663601)^{1, 9} Aoyama K....Suzumori K. (2004)
Site-directed mutagenesis of alpha II spectrin at codon 1175 modulates its mu-calpain susceptibility. (PubMed id 8993318)^{1, 9} Stabach P.R.... Morrow J.S. (1997)
Platelet sarcoplasmic endoplasmic reticulum Ca2+-ATPase and mu-calpain activity are altered in type 2 diabetes mellitus and restored by rosiglitazone. (PubMed id 18071073)^{1, 9} Randriamboavonjy V....Fleming I. (2008)
The PEST domain of IkappaBalpha is necessary and sufficient for in vitro degradation by mu-calpain. (PubMed id 10521480)^{1, 9} Shumway S.D....Miyamoto S. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 823	HGNC: 1476	AceView: CAPN1	Ensembl:ENSG00000014216	euGenes: HUgn823
ECgene: CAPN1	Kegg: 823	H-InvDB: CAPN1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CAPN1	Pharmacogenomics, SNPs, Pathways
CaBP	http://structbio.vanderbilt.edu/cabp_database/general/prot_pages/calpain.html
Calpains homepage	http://ag.arizona.edu/calpains/
NIEHS-SNPs	http://egp.gs.washington.edu/data/capn1/

Intellectual Property for CAPN1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CAPN1 gene:
Search GeneIP for patents involving CAPN1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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CAPN1 Gene

calpain 1, (mu/I) large subunit

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CAPN1 Gene

calpain 1, (mu/I) large subunit

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