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Aliases for CAPN1 Gene

Aliases for CAPN1 Gene

  • Calpain 1 2 3 5
  • Cell Proliferation-Inducing Gene 30 Protein 3 4
  • Calcium-Activated Neutral Proteinase 1 3 4
  • Calpain 1, (Mu/I) Large Subunit 2 3
  • Calpain-1 Large Subunit 3 4
  • Micromolar-Calpain 3 4
  • Calpain Mu-Type 3 4
  • EC 3.4.22.52 4 61
  • CANP 1 3 4
  • CANPL1 3 4
  • MuCANP 3 4
  • Cell Proliferation-Inducing Protein 30 3
  • Calpain, Large Polypeptide L1 3
  • Calpain-1 Catalytic Subunit 3
  • EC 3.4.22 61
  • CANP1 3
  • SPG76 3
  • CANP 3
  • MuCL 3

External Ids for CAPN1 Gene

Previous GeneCards Identifiers for CAPN1 Gene

  • GC11P067465
  • GC11P066630
  • GC11P064724
  • GC11P064705
  • GC11P064950
  • GC11P061278

Summaries for CAPN1 Gene

Entrez Gene Summary for CAPN1 Gene

  • The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for CAPN1 Gene

CAPN1 (Calpain 1) is a Protein Coding gene. Among its related pathways are Alzheimers Disease Pathway and Apoptosis Pathway. GO annotations related to this gene include calcium ion binding and calcium-dependent cysteine-type endopeptidase activity. An important paralog of this gene is CAPN2.

UniProtKB/Swiss-Prot for CAPN1 Gene

  • Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

Tocris Summary for CAPN1 Gene

  • Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure.

Gene Wiki entry for CAPN1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPN1 Gene

Genomics for CAPN1 Gene

Regulatory Elements for CAPN1 Gene

Enhancers for CAPN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CAPN1 on UCSC Golden Path with GeneCards custom track

Promoters for CAPN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CAPN1 Gene

Chromosome:
11
Start:
65,180,566 bp from pter
End:
65,212,006 bp from pter
Size:
31,441 bases
Orientation:
Plus strand

Genomic View for CAPN1 Gene

Genes around CAPN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPN1 Gene

Proteins for CAPN1 Gene

  • Protein details for CAPN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07384-CAN1_HUMAN
    Recommended name:
    Calpain-1 catalytic subunit
    Protein Accession:
    P07384
    Secondary Accessions:
    • Q2TTR0
    • Q6DHV4

    Protein attributes for CAPN1 Gene

    Size:
    714 amino acids
    Molecular mass:
    81890 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Forms a heterodimer with a small (regulatory) subunit (CAPNS1).

    Three dimensional structures from OCA and Proteopedia for CAPN1 Gene

neXtProt entry for CAPN1 Gene

Post-translational modifications for CAPN1 Gene

  • Undergoes calcium-induced successive autoproteolytic cleavages that generate a membrane-bound 78 kDa active form and an intracellular 75 kDa active form. Calpastatin reduces with high efficiency the transition from 78 kDa to 75 kDa calpain forms.
  • Ubiquitination at Lys 365, Lys 398, Lys 461, and Lys 583
  • Modification sites at PhosphoSitePlus

Domains & Families for CAPN1 Gene

Gene Families for CAPN1 Gene

Suggested Antigen Peptide Sequences for CAPN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P07384

UniProtKB/Swiss-Prot:

CAN1_HUMAN :
  • Contains 1 calpain catalytic domain.
  • Belongs to the peptidase C2 family.
Domain:
  • Contains 1 calpain catalytic domain.
  • Contains 4 EF-hand domains.
Family:
  • Belongs to the peptidase C2 family.
genes like me logo Genes that share domains with CAPN1: view

Function for CAPN1 Gene

Molecular function for CAPN1 Gene

GENATLAS Biochemistry:
calpain,large polypeptide L1,calcium dependent neutral cysteine proteinase,papain superfamily,mu type (not mutated in MEN1)
UniProtKB/Swiss-Prot CatalyticActivity:
Broad endopeptidase specificity.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by micromolar concentrations of calcium and inhibited by calpastatin.
UniProtKB/Swiss-Prot Function:
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

Enzyme Numbers (IUBMB) for CAPN1 Gene

Gene Ontology (GO) - Molecular Function for CAPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004198 calcium-dependent cysteine-type endopeptidase activity ISS --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IEA,IPI 9407132
GO:0008092 cytoskeletal protein binding IEA --
genes like me logo Genes that share ontologies with CAPN1: view
genes like me logo Genes that share phenotypes with CAPN1: view

Animal Models for CAPN1 Gene

MGI Knock Outs for CAPN1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CAPN1

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAPN1 Gene

Localization for CAPN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPN1 Gene

Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding. In granular keratinocytes and in lower corneocytes, colocalizes with FLG and FLG2 (PubMed:21531719). {ECO:0000269 PubMed:21531719}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAPN1 Gene COMPARTMENTS Subcellular localization image for CAPN1 gene
Compartment Confidence
cytosol 5
extracellular 5
plasma membrane 4
mitochondrion 3
cytoskeleton 2
lysosome 2
nucleus 2
vacuole 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CAPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005764 lysosome IEA --
GO:0005829 cytosol IEA,TAS --
GO:0005886 plasma membrane IDA 12150984
genes like me logo Genes that share ontologies with CAPN1: view

Pathways & Interactions for CAPN1 Gene

genes like me logo Genes that share pathways with CAPN1: view

Pathways by source for CAPN1 Gene

Gene Ontology (GO) - Biological Process for CAPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,ISS --
GO:0008284 positive regulation of cell proliferation TAS 8702541
GO:0016241 regulation of macroautophagy NAS 17264674
GO:0016540 protein autoprocessing IEA --
GO:0022617 extracellular matrix disassembly TAS --
genes like me logo Genes that share ontologies with CAPN1: view

No data available for SIGNOR curated interactions for CAPN1 Gene

Drugs & Compounds for CAPN1 Gene

(22) Drugs for CAPN1 Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE Experimental Pharma Target 0
CBZ-LEU-LEU-TYR-CH2F Experimental Pharma Target 0
N-[N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-Butyl]-Guanidine Experimental Pharma Target 0
Acetyl-Calpastatin (184-210) (human) Pharma Calpain I/II inhibitor, Selective calpain inhibitor 0
Calpeptin Pharma Ca2+-dependent protease,calpain inhibitor, Calpain and cathepsin L inhibitor 0

(10) Additional Compounds for CAPN1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
MG 132
133407-82-6

(2) Tocris Compounds for CAPN1 Gene

Compound Action Cas Number
Acetyl-Calpastatin (184-210) (human) Selective calpain inhibitor 123714-50-1
MG 132 Proteasome and calpain inhibitor. Inhibits NF-kappaB activation 133407-82-6

(7) ApexBio Compounds for CAPN1 Gene

Compound Action Cas Number
Acetyl-Calpastatin (184-210) (human) Calpain I/II inhibitor 123714-50-1
Calpain Inhibitor I, ALLN Calpain I/II/ B/L inhibitor 110044-82-1
Calpain Inhibitor II, ALLM Calpain inhibitor 136632-32-1
Calpeptin Ca2+-dependent protease,calpain inhibitor 117591-20-5
MDL 28170 Calpain and cathepsin B inhibitor, selective 88191-84-8
PD 150606 Non-peptide calpain inhibitor 179528-45-1
PD 151746 calpain inhibitor, cell-permeable 179461-52-0
genes like me logo Genes that share compounds with CAPN1: view

Drug Products

Transcripts for CAPN1 Gene

Unigene Clusters for CAPN1 Gene

Calpain 1, (mu/I) large subunit:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CAPN1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAPN1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e ^ 12a · 12b · 12c ·
SP1:
SP2: - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5:
SP6: - - - - - - - - - - -
SP7: - -
SP8: - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - -
SP11:
SP12: - - - - - - - -
SP13: - - - -
SP14:
SP15: - - - -
SP16: - - - - - - - - - -
SP17: - - - - - - - - -
SP18:
SP19:
SP20:
SP21: - - - - - -
SP22: -
SP23:

ExUns: 12d · 12e ^ 13a · 13b ^ 14a · 14b · 14c · 14d ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b · 25c ^ 26 ^
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5: - - - -
SP6:
SP7: - - - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - -
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:

ExUns: 27 ^ 28a · 28b ^ 29 ^ 30a · 30b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:

Relevant External Links for CAPN1 Gene

GeneLoc Exon Structure for
CAPN1
ECgene alternative splicing isoforms for
CAPN1

Expression for CAPN1 Gene

mRNA expression in normal human tissues for CAPN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAPN1 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CAPN1 Gene



Protein tissue co-expression partners for CAPN1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CAPN1 Gene:

CAPN1

SOURCE GeneReport for Unigene cluster for CAPN1 Gene:

Hs.502842

mRNA Expression by UniProt/SwissProt for CAPN1 Gene:

P07384-CAN1_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with CAPN1: view

Primer Products

No data available for Protein differential expression in normal tissues for CAPN1 Gene

Orthologs for CAPN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPN1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CAPN1 34
  • 90.9 (n)
  • 94.82 (a)
CAPN1 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAPN1 34
  • 91.75 (n)
  • 97.05 (a)
CAPN1 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Capn1 34
  • 85.97 (n)
  • 89.34 (a)
Capn1 16
Capn1 35
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CAPN1 34
  • 99.3 (n)
  • 99.72 (a)
CAPN1 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Capn1 34
  • 85.74 (n)
  • 89.34 (a)
oppossum
(Monodelphis domestica)
Mammalia CAPN1 35
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAPN1 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves CAPN1 34
  • 77.92 (n)
  • 82.07 (a)
CAPN1 35
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAPN1 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia capn1 34
  • 69.61 (n)
  • 76.86 (a)
African clawed frog
(Xenopus laevis)
Amphibia capn1-prov 34
zebrafish
(Danio rerio)
Actinopterygii Dr.17116 34
zgc:55262 34
  • 68.04 (n)
  • 70.45 (a)
CAPN1 (1 of 2) 35
  • 71 (a)
OneToMany
CAPN1 (2 of 2) 35
  • 66 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CalpA 36
  • 48 (a)
CalpB 36
  • 44 (a)
CalpC 36
  • 28 (a)
worm
(Caenorhabditis elegans)
Secernentea clp-3 36
  • 37 (a)
clp-6 36
  • 43 (a)
clp-7 36
  • 47 (a)
Species where no ortholog for CAPN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAPN1 Gene

ENSEMBL:
Gene Tree for CAPN1 (if available)
TreeFam:
Gene Tree for CAPN1 (if available)

Paralogs for CAPN1 Gene

genes like me logo Genes that share paralogs with CAPN1: view

Variants for CAPN1 Gene

Sequence variations from dbSNP and Humsavar for CAPN1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_021085 -
rs10895991 - 65,204,815(+) GCGCC(A/C/G)CTTCG nc-transcript-variant, reference, missense
rs17883283 - 65,206,583(+) CACCC(A/G)GGGAG nc-transcript-variant, reference, missense
rs17884773 - 65,210,419(+) ATTTC(A/G)TTTGC nc-transcript-variant, reference, missense
rs1195732 -- 65,201,675(+) accac(A/G)cccgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAPN1 Gene

Variant ID Type Subtype PubMed ID
nsv1070043 CNV deletion 25765185
nsv1136131 CNV deletion 24896259
nsv509418 CNV insertion 20534489
nsv526181 CNV gain 19592680
nsv832190 CNV loss 17160897

Variation tolerance for CAPN1 Gene

Residual Variation Intolerance Score: 62.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.05; 68.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAPN1 Gene

Human Gene Mutation Database (HGMD)
CAPN1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAPN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPN1 Gene

Disorders for CAPN1 Gene

Relevant External Links for CAPN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAPN1

No disorders were found for CAPN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAPN1 Gene

Publications for CAPN1 Gene

  1. Complete amino acid sequence of the large subunit of the low-Ca2+- requiring form of human Ca2+-activated neutral protease (muCANP) deduced from its cDNA sequence. (PMID: 3017764) Aoki K. … Suzuki K. (FEBS Lett. 1986) 2 3 4 65
  2. Deimination of human filaggrin-2 promotes its proteolysis by calpain 1. (PMID: 21531719) Hsu C.Y. … Simon M. (J. Biol. Chem. 2011) 3 4 65
  3. Calpain-mediated activation of NO synthase in human neuroblastoma SK-N-BE cells. (PMID: 19457105) Averna M. … Melloni E. (J. Neurochem. 2009) 3 22 65
  4. Platelet sarcoplasmic endoplasmic reticulum Ca2+-ATPase and mu-calpain activity are altered in type 2 diabetes mellitus and restored by rosiglitazone. (PMID: 18071073) Randriamboavonjy V. … Fleming I. (Circulation 2008) 3 22 65
  5. Necessity of inositol (1,4,5)-trisphosphate receptor 1 and mu-calpain in NO-induced osteoclast motility. (PMID: 17690304) Yaroslavskiy B.B. … Blair H.C. (J. Cell. Sci. 2007) 3 22 65

Products for CAPN1 Gene

  • Addgene plasmids for CAPN1

Sources for CAPN1 Gene

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