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Aliases for CAPG Gene

Aliases for CAPG Gene

  • Capping Actin Protein, Gelsolin Like 2 3
  • Capping Protein (Actin Filament), Gelsolin-Like 2 3 5
  • Actin Regulatory Protein CAP-G 3 4
  • Macrophage Capping Protein 2 3
  • AFCP 3 4
  • MCP 3 4
  • Epididymis Secretory Protein Li 66 3
  • Actin-Regulatory Protein CAP-G 3
  • Gelsolin-Like Capping Protein 3
  • HEL-S-66 3

External Ids for CAPG Gene

Previous HGNC Symbols for CAPG Gene

  • AFCP

Previous GeneCards Identifiers for CAPG Gene

  • GC02M085517
  • GC02M085915
  • GC02M085579
  • GC02M085596
  • GC02M085533
  • GC02M085475
  • GC02M085621
  • GC02M085520

Summaries for CAPG Gene

Entrez Gene Summary for CAPG Gene

  • This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for CAPG Gene

CAPG (Capping Actin Protein, Gelsolin Like) is a Protein Coding gene. GO annotations related to this gene include actin binding and protein complex binding. An important paralog of this gene is VIL1.

UniProtKB/Swiss-Prot for CAPG Gene

  • Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.

Gene Wiki entry for CAPG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPG Gene

Genomics for CAPG Gene

Regulatory Elements for CAPG Gene

Enhancers for CAPG Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CAPG on UCSC Golden Path with GeneCards custom track

Promoters for CAPG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CAPG on UCSC Golden Path with GeneCards custom track

Genomic Location for CAPG Gene

Chromosome:
2
Start:
85,394,748 bp from pter
End:
85,418,467 bp from pter
Size:
23,720 bases
Orientation:
Minus strand

Genomic View for CAPG Gene

Genes around CAPG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPG Gene

Proteins for CAPG Gene

  • Protein details for CAPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40121-CAPG_HUMAN
    Recommended name:
    Macrophage-capping protein
    Protein Accession:
    P40121
    Secondary Accessions:
    • B8ZZS7
    • D6W5K8
    • Q53SA7

    Protein attributes for CAPG Gene

    Size:
    348 amino acids
    Molecular mass:
    38499 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CAPG Gene

    Alternative splice isoforms for CAPG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAPG Gene

Proteomics data for CAPG Gene at MOPED

Post-translational modifications for CAPG Gene

No data available for DME Specific Peptides for CAPG Gene

Domains & Families for CAPG Gene

Gene Families for CAPG Gene

Protein Domains for CAPG Gene

Suggested Antigen Peptide Sequences for CAPG Gene

Graphical View of Domain Structure for InterPro Entry

P40121

UniProtKB/Swiss-Prot:

CAPG_HUMAN :
  • Belongs to the villin/gelsolin family.
  • Contains 3 gelsolin-like repeats.
Family:
  • Belongs to the villin/gelsolin family.
Similarity:
  • Contains 3 gelsolin-like repeats.
genes like me logo Genes that share domains with CAPG: view

Function for CAPG Gene

Molecular function for CAPG Gene

GENATLAS Biochemistry:
CapG,macrophage capping protein (gelsolin/villin family of actin regulatory protein)
UniProtKB/Swiss-Prot Function:
Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.

Gene Ontology (GO) - Molecular Function for CAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with CAPG: view
genes like me logo Genes that share phenotypes with CAPG: view

Animal Models for CAPG Gene

MGI Knock Outs for CAPG:

Animal Model Products

miRNA for CAPG Gene

miRTarBase miRNAs that target CAPG

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAPG Gene

Localization for CAPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPG Gene

Cytoplasm. Nucleus. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAPG Gene COMPARTMENTS Subcellular localization image for CAPG gene
Compartment Confidence
cytoskeleton 5
extracellular 5
nucleus 5
cytosol 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for CAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA 18938132
GO:0005737 cytoplasm IDA 18266911
GO:0042470 melanosome IEA --
GO:0070062 extracellular exosome IDA 19056867
GO:0072686 mitotic spindle IDA 19166812
genes like me logo Genes that share ontologies with CAPG: view

Pathways & Interactions for CAPG Gene

SuperPathways for CAPG Gene

No Data Available

Gene Ontology (GO) - Biological Process for CAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022617 NOT extracellular matrix disassembly IMP 24236012
genes like me logo Genes that share ontologies with CAPG: view

No data available for Pathways by source and SIGNOR curated interactions for CAPG Gene

Drugs & Compounds for CAPG Gene

(2) Drugs for CAPG Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vincristine Approved, Investigational Pharma Microtubule disrupter,antitumor agent 870
calcium Nutra 0

(1) Additional Compounds for CAPG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CAPG: view

Transcripts for CAPG Gene

Unigene Clusters for CAPG Gene

Capping protein (actin filament), gelsolin-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAPG Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
SP1: - - -
SP2: -
SP3: - - - -
SP4: - -
SP5: - -
SP6: -
SP7: -
SP8: -
SP9:

Relevant External Links for CAPG Gene

GeneLoc Exon Structure for
CAPG
ECgene alternative splicing isoforms for
CAPG

Expression for CAPG Gene

mRNA expression in normal human tissues for CAPG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAPG Gene

This gene is overexpressed in Whole Blood (x9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAPG Gene



SOURCE GeneReport for Unigene cluster for CAPG Gene Hs.516155

mRNA Expression by UniProt/SwissProt for CAPG Gene

P40121-CAPG_HUMAN
Tissue specificity: Macrophages and macrophage-like cells.
genes like me logo Genes that share expression patterns with CAPG: view

Protein tissue co-expression partners for CAPG Gene

- Elite partner

Primer Products

No data available for Protein differential expression in normal tissues for CAPG Gene

Orthologs for CAPG Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CAPG 35
  • 87.74 (n)
  • 91.09 (a)
CAPG 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAPG 35
  • 91.19 (n)
  • 95.11 (a)
CAPG 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Capg 35
  • 89.37 (n)
  • 92.82 (a)
Capg 16
Capg 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CAPG 35
  • 99.52 (n)
  • 99.71 (a)
CAPG 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Capg 35
  • 88.31 (n)
  • 92.82 (a)
oppossum
(Monodelphis domestica)
Mammalia CAPG 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAPG 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves CAPG 35
  • 69.84 (n)
  • 66.57 (a)
CAPG 36
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAPG 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia capg 35
  • 55.33 (n)
  • 51.74 (a)
zebrafish
(Danio rerio)
Actinopterygii capgb 35
  • 61.86 (n)
  • 57.36 (a)
wufb14e07 35
capga 36
  • 55 (a)
OneToMany
capgb 36
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K06A4.3 37
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6001 36
  • 5 (a)
OneToMany
Species with no ortholog for CAPG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAPG Gene

ENSEMBL:
Gene Tree for CAPG (if available)
TreeFam:
Gene Tree for CAPG (if available)

Paralogs for CAPG Gene

Paralogs for CAPG Gene

(7) SIMAP similar genes for CAPG Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CAPG: view

Variants for CAPG Gene

Sequence variations from dbSNP and Humsavar for CAPG Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2229668 - 85,401,860(-) AGGGC(A/G)TCTTC reference, missense
rs11539103 - 85,399,210(-) CCATC(C/T)GGGAC reference, missense
rs6886 - 85,394,936(-) GGGCC(A/G)TGAGA reference, missense
rs1803947 -- 85,394,897(-) CTGGA(A/T)ATGAG reference, missense
rs2002444 -- 85,401,433(+) TCCAA(A/G)GGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAPG Gene

Variant ID Type Subtype PubMed ID
nsv834282 CNV Gain 17160897
nsv834283 CNV Loss 17160897

Variation tolerance for CAPG Gene

Residual Variation Intolerance Score: 62.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.22; 52.39% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CAPG Gene

Disorders for CAPG Gene

Relevant External Links for CAPG

Genetic Association Database (GAD)
CAPG
Human Genome Epidemiology (HuGE) Navigator
CAPG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAPG

No disorders were found for CAPG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAPG Gene

Publications for CAPG Gene

  1. Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages. (PMID: 1322908) Dabiri G.A. … Southwick F.S. (J. Biol. Chem. 1992) 2 3 4 23 67
  2. Cap G, a gelsolin family protein modulating protective effects of unidirectional shear stress. (PMID: 12754261) Pellieux C. … Silacci P. (J. Biol. Chem. 2003) 2 3 23
  3. Up-regulation of two actin-associated proteins prompts pulmonary artery smooth muscle cell migration under hypoxia. (PMID: 19188659) Zhang R. … Wan H. (Am. J. Respir. Cell Mol. Biol. 2009) 3 23
  4. Invasive breast cancer cells exhibit increased mobility of the actin-binding protein CapG. (PMID: 18059028) Renz M. … Langowski J. (Int. J. Cancer 2008) 3 23
  5. Clinical significance of gelsolin-like actin-capping protein expression in oral carcinogenesis: an immunohistochemical study of premalignant and malignant lesions of the oral cavity. (PMID: 18237446) Nomura H. … Tanzawa H. (BMC Cancer 2008) 3 23

Products for CAPG Gene

Sources for CAPG Gene

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