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Aliases for CAPG Gene

Aliases for CAPG Gene

  • Capping Protein (Actin Filament), Gelsolin-Like 2 3
  • Actin Regulatory Protein CAP-G 3 4
  • Macrophage Capping Protein 2 3
  • AFCP 3 4
  • MCP 3 4
  • Epididymis Secretory Protein Li 66 3
  • Actin-Regulatory Protein CAP-G 3
  • Gelsolin-Like Capping Protein 3
  • Macrophage-Capping Protein 3
  • HEL-S-66 3

External Ids for CAPG Gene

Previous HGNC Symbols for CAPG Gene

  • AFCP

Previous GeneCards Identifiers for CAPG Gene

  • GC02M085517
  • GC02M085915
  • GC02M085579
  • GC02M085596
  • GC02M085533
  • GC02M085475
  • GC02M085621
  • GC02M085520

Summaries for CAPG Gene

Entrez Gene Summary for CAPG Gene

  • This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for CAPG Gene

CAPG (Capping Protein (Actin Filament), Gelsolin-Like) is a Protein Coding gene. GO annotations related to this gene include actin binding. An important paralog of this gene is AVIL.

UniProtKB/Swiss-Prot for CAPG Gene

  • Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA

Gene Wiki entry for CAPG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPG Gene

Genomics for CAPG Gene

Regulatory Elements for CAPG Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CAPG Gene

Start:
85,394,748 bp from pter
End:
85,418,432 bp from pter
Size:
23,685 bases
Orientation:
Minus strand

Genomic View for CAPG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPG Gene

Proteins for CAPG Gene

  • Protein details for CAPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40121-CAPG_HUMAN
    Recommended name:
    Macrophage-capping protein
    Protein Accession:
    P40121
    Secondary Accessions:
    • B8ZZS7
    • D6W5K8
    • Q53SA7

    Protein attributes for CAPG Gene

    Size:
    348 amino acids
    Molecular mass:
    38499 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CAPG Gene

    Alternative splice isoforms for CAPG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAPG Gene

Proteomics data for CAPG Gene at MOPED

Post-translational modifications for CAPG Gene

Antibody Products

No data available for DME Specific Peptides for CAPG Gene

Domains for CAPG Gene

Protein Domains for CAPG Gene

Suggested Antigen Peptide Sequences for CAPG Gene

Graphical View of Domain Structure for InterPro Entry

P40121

UniProtKB/Swiss-Prot:

CAPG_HUMAN :
  • P40121
Family:
  • Belongs to the villin/gelsolin family.
Similarity:
  • Contains 3 gelsolin-like repeats.
genes like me logo Genes that share domains with CAPG: view

No data available for Gene Families for CAPG Gene

Function for CAPG Gene

Molecular function for CAPG Gene

GENATLAS Biochemistry: CapG,macrophage capping protein (gelsolin/villin family of actin regulatory protein)
UniProtKB/Swiss-Prot Function: Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA

Gene Ontology (GO) - Molecular Function for CAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 18266911
GO:0019904 protein domain specific binding IPI 18266911
GO:0032403 protein complex binding IDA 18266911
genes like me logo Genes that share ontologies with CAPG: view
genes like me logo Genes that share phenotypes with CAPG: view

Animal Models for CAPG Gene

MGI Knock Outs for CAPG:

Animal Model Products

CRISPR Products

miRNA for CAPG Gene

miRTarBase miRNAs that target CAPG

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAPG

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CAPG Gene

Localization for CAPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPG Gene

Cytoplasm. Nucleus. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAPG Gene COMPARTMENTS Subcellular localization image for CAPG gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for CAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA 18938132
GO:0005730 nucleolus IDA 18938132
GO:0005737 cytoplasm IDA 18266911
GO:0005814 centriole IDA 19166812
genes like me logo Genes that share ontologies with CAPG: view

Pathways for CAPG Gene

SuperPathways for CAPG Gene

No Data Available

Gene Ontology (GO) - Biological Process for CAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly NAS 1322908
GO:0022617 NOT extracellular matrix disassembly IMP 24236012
GO:0030031 cell projection assembly IEA --
GO:0051016 barbed-end actin filament capping IEA --
GO:0071803 NOT positive regulation of podosome assembly IMP 24236012
genes like me logo Genes that share ontologies with CAPG: view

No data available for Pathways by source for CAPG Gene

Compounds for CAPG Gene

(1) HMDB Compounds for CAPG Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(2) Novoseek inferred chemical compound relationships for CAPG Gene

Compound -log(P) Hits PubMed IDs
pip2 66.4 5
calcium 0 3
genes like me logo Genes that share compounds with CAPG: view

Transcripts for CAPG Gene

Unigene Clusters for CAPG Gene

Capping protein (actin filament), gelsolin-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAPG

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAPG Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
SP1: - - -
SP2: -
SP3: - - - -
SP4: - -
SP5: - -
SP6: -
SP7: -
SP8: -
SP9:

Relevant External Links for CAPG Gene

GeneLoc Exon Structure for
CAPG
ECgene alternative splicing isoforms for
CAPG

Expression for CAPG Gene

mRNA expression in normal human tissues for CAPG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAPG Gene

This gene is overexpressed in Whole Blood (9.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAPG Gene

SOURCE GeneReport for Unigene cluster for CAPG Gene Hs.516155

mRNA Expression by UniProt/SwissProt for CAPG Gene

P40121-CAPG_HUMAN
Tissue specificity: Macrophages and macrophage-like cells
genes like me logo Genes that share expressions with CAPG: view

In Situ Assay Products

Orthologs for CAPG Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAPG 35
  • 99.52 (n)
  • 99.71 (a)
CAPG 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CAPG 35
  • 87.74 (n)
  • 91.09 (a)
CAPG 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAPG 35
  • 91.19 (n)
  • 95.11 (a)
CAPG 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Capg 35
  • 89.37 (n)
  • 92.82 (a)
Capg 16
Capg 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CAPG 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAPG 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Capg 35
  • 88.31 (n)
  • 92.82 (a)
chicken
(Gallus gallus)
Aves CAPG 35
  • 69.84 (n)
  • 66.57 (a)
CAPG 36
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAPG 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia capg 35
  • 55.33 (n)
  • 51.74 (a)
zebrafish
(Danio rerio)
Actinopterygii capga 36
  • 55 (a)
OneToMany
capgb 35
  • 61.86 (n)
  • 57.36 (a)
capgb 36
  • 50 (a)
OneToMany
wufb14e07 35
worm
(Caenorhabditis elegans)
Secernentea K06A4.3 37
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6001 36
  • 5 (a)
OneToMany
Species with no ortholog for CAPG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAPG Gene

ENSEMBL:
Gene Tree for CAPG (if available)
TreeFam:
Gene Tree for CAPG (if available)

Paralogs for CAPG Gene

Paralogs for CAPG Gene

Selected SIMAP similar genes for CAPG Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CAPG: view

Variants for CAPG Gene

Sequence variations from dbSNP and Humsavar for CAPG Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs6885 -- 85,398,099(-) AGCCC(A/C)TTTGC reference, synonymous-codon
rs6886 - 85,394,936(-) GGGCC(A/G)TGAGA reference, missense
rs1131549 -- 85,394,949(-) AGATT(C/T)TGCCT reference, synonymous-codon
rs1803947 -- 85,394,897(-) CTGGA(A/T)ATGAG reference, missense
rs2002444 -- 85,401,433(+) TCCAA(A/G)GGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAPG Gene

Variant ID Type Subtype PubMed ID
nsv834282 CNV Gain 17160897
nsv834283 CNV Loss 17160897

Relevant External Links for CAPG Gene

HapMap Linkage Disequilibrium report
CAPG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPG Gene

Disorders for CAPG Gene

(1) Novoseek inferred disease relationships for CAPG Gene

Disease -log(P) Hits PubMed IDs
cancer 8.5 7

Relevant External Links for CAPG

Genetic Association Database (GAD)
CAPG
Human Genome Epidemiology (HuGE) Navigator
CAPG
genes like me logo Genes that share disorders with CAPG: view

No data available for UniProtKB/Swiss-Prot for CAPG Gene

Publications for CAPG Gene

  1. Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages. (PMID: 1322908) Dabiri G.A. … Southwick F.S. (J. Biol. Chem. 1992) 2 3 4 23
  2. Cap G, a gelsolin family protein modulating protective effects of unidirectional shear stress. (PMID: 12754261) Pellieux C. … Silacci P. (J. Biol. Chem. 2003) 2 3 23
  3. The human actin-regulatory protein cap G: gene structure and chromosome location. (PMID: 7851883) Mishra V.S. … Southwick F.S. (Genomics 1994) 3 4 23
  4. Increased importin-beta-dependent nuclear import of the actin modulating protein CapG promotes cell invasion. (PMID: 15454578) De Corte V. … Gettemans J. (J. Cell. Sci. 2004) 3 23
  5. Invasive breast cancer cells exhibit increased mobility of the actin-binding protein CapG. (PMID: 18059028) Renz M. … Langowski J. (Int. J. Cancer 2008) 3 23

Products for CAPG Gene

Sources for CAPG Gene

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