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CAPG Gene

protein-coding   GIFtS: 61
GCID: GC02M085621

Capping Protein (Actin Filament), Gelsolin-Like


(Previous symbol: AFCP)
  Search for CAPG
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Capping Protein (Actin Filament), Gelsolin-Like1 2     HEL-S-662
AFCP1 2 3     Actin-Regulatory Protein CAP-G2
Macrophage Capping Protein1 2     Epididymis Secretory Protein Li 662
Actin Regulatory Protein CAP-G2 3     Gelsolin-Like Capping Protein2
MCP2 3     Macrophage-Capping Protein2

External Ids:    HGNC: 14741   Entrez Gene: 8222   Ensembl: ENSG000000424937   OMIM: 1536155   UniProtKB: P401213   

Export aliases for CAPG gene to outside databases

Previous GC identifers: GC02M085517 GC02M085915 GC02M085579 GC02M085596 GC02M085533 GC02M085475 GC02M085520


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CAPG Gene:
This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein
reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does
not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein
contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants
have been observed for this gene. (provided by RefSeq, Jan 2012)

GeneCards Summary for CAPG Gene:
CAPG (capping protein (actin filament), gelsolin-like) is a protein-coding gene. GO annotations related to this gene include actin binding. An important paralog of this gene is SVIL.

UniProtKB/Swiss-Prot: CAPG_HUMAN, P40121
Function: Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever
preformed actin filaments. May play an important role in macrophage function. May play a role in regulating
cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA

Gene Wiki entry for CAPG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CAPG gene promoter:
         Spz1   GATA-3   AML1a   GATA-2   GATA-1   E47   PPAR-gamma1   POU2F1   POU2F1a   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCAPG promoter sequence
   Search Chromatin IP Primers for CAPG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CAPG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11.2   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.2

CAPG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAPG gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M085621:  view genomic region     (about GC identifiers)

Start:
85,621,871 bp from pter      End:
85,645,555 bp from pter
Size:
23,685 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CAPG_HUMAN, P40121 (See protein sequence)
Recommended Name: Macrophage-capping protein  
Size: 348 amino acids; 38499 Da
Caution: This protein was originally thought to be a DNA-binding protein with a helix-loop-helix domain
2 PDB 3D structures from and Proteopedia for CAPG:
1J72 (3D)        1JHW (3D)    
Secondary accessions: B8ZZS7 D6W5K8 Q53SA7
Alternative splicing: 2 isoforms:  P40121-1   P40121-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CAPG: NX_P40121

Explore proteomics data for CAPG at MOPED

Post-translational modifications: 

  • The N-terminus is blocked1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CAPG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001243068.1  NP_001243069.1  NP_001738.2  

    ENSEMBL proteins: 
     ENSP00000263867   ENSP00000397381   ENSP00000387063   ENSP00000386315   ENSP00000386965  
     ENSP00000391923   ENSP00000403330   ENSP00000398232   ENSP00000386596  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR007122 Villin/Gelsolin
     IPR007123 Gelsolin_dom

    Graphical View of Domain Structure for InterPro Entry P40121

    ProtoNet protein and cluster: P40121

    UniProtKB/Swiss-Prot: CAPG_HUMAN, P40121
    Similarity: Belongs to the villin/gelsolin family
    Similarity: Contains 3 gelsolin-like repeats


    Find genes that share domains with CAPG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAPG_HUMAN, P40121
    Function: Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever
    preformed actin filaments. May play an important role in macrophage function. May play a role in regulating
    cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA

         Genatlas biochemistry entry for CAPG:
    CapG,macrophage capping protein (gelsolin/villin family of actin regulatory protein)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
         
    Find genes that share ontologies with CAPG           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Capg):
     cellular  hematopoietic system  immune system 

    Find genes that share phenotypes with CAPG           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Capgtm1Djk for CAPG

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CAPG
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAPG

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    miRTarBase miRNAs that target CAPG:
    hsa-mir-1 (MIRT023906), hsa-let-7b-5p (MIRT001646), hsa-mir-34a-5p (MIRT025493)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CAPG_HUMAN, P40121: Cytoplasm. Nucleus. Melanosome. Note=Identified by mass spectrometry in melanosome fractions
    from stage I to stage IV
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol3
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0008290F-actin capping protein complex TAS1322908
    GO:0031965nuclear membrane IDA--

    Find genes that share ontologies with CAPG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CAPG
    Interactions:

        GeneGlobe Interaction Network for CAPG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for CAPG (P401212, 3 ENSP000002638674) via UniProtKB, MINT, STRING, and/or I2D (see all 785)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCAPHQ150032, 3, ENSP000002404234MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000240423
    SMC2O953472, ENSP000002863984MINT-7945693 MINT-7947479 STRING: ENSP00000286398
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    CAPZA1P529072, ENSP000002631684MINT-7945693 MINT-7947479 STRING: ENSP00000263168
    NCAPD2Q150212, ENSP000003250174MINT-7945693 MINT-7947479 STRING: ENSP00000325017
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly NAS1322908
    GO:0030031cell projection assembly IEA--
    GO:0051016barbed-end actin filament capping TAS1322908

    Find genes that share ontologies with CAPG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CAPG

    1 HMDB Compound for CAPG    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 Novoseek inferred chemical compound relationships for CAPG gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pip2 66.4 6 9265648 (3), 9252353 (1), 7698981 (1)
    calcium 0 4 8188679 (2), 9252353 (1)



    Find genes that share compounds with CAPG           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CAPG gene (3 alternative transcripts): 
    NM_001256139.1  NM_001256140.1  NM_001747.3  

    Unigene Cluster for CAPG:

    Capping protein (actin filament), gelsolin-like
    Hs.516155  [show with all ESTs]
    Unigene Representative Sequence: AK300507
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263867(uc002spl.1 uc002spm.1 uc010fgi.1) ENST00000453973
    ENST00000409921 ENST00000409670 ENST00000409724(uc010fgj.1) ENST00000471064
    ENST00000483659 ENST00000439385 ENST00000449030 ENST00000447219 ENST00000459793
    ENST00000409275 ENST00000415012 ENST00000491267 ENST00000479651
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      QuantiTect SYBR Green Assays in human, mouse, rat CAPG
      QuantiFast Probe-based Assays in human, mouse, rat CAPG

    Additional mRNA sequence: 

    AK130130.1 AK225374.1 AK225378.1 AK300507.1 AK309290.1 AK313898.1 BC000728.2 BC014549.1 
    M94345.1 

    21 DOTS entries:

    DT.95134436  DT.416533  DT.95134370  DT.97820036  DT.92452320  DT.100039439  DT.95134378  DT.100039434 
    DT.91695992  DT.97862251  DT.95334446  DT.120985593  DT.121120260  DT.87001323  DT.100881157  DT.120985611 
    DT.92452321  DT.92452324  DT.95134355  DT.95134435  DT.97862250 

    Selected AceView cDNA sequences (see all 612):

    BM470864 CR604518 AW270152 CB993818 BF221769 BQ420938 CA421855 BQ933730 
    BU527388 BG281354 CR613753 CD697267 H49082 CR607458 AI420886 BQ691419 
    BQ217642 BU500981 BG762736 BU156879 BQ931966 BQ683793 BG766121 BP360097 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CAPG (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                            -                                               -           -                     
    SP2:                                            -                                                                                 
    SP3:                                            -                                   -     -     -                                 
    SP4:                                            -                                               -                                 
    SP5:                                            -     -                                                                           


    ECgene alternative splicing isoforms for CAPG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CAPG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCCCCTGCC
    CAPG Expression
    About this image


    CAPG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Eye (Sensory Organs)
             Corneal Epithelium
    CAPG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CAPG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516155

    UniProtKB/Swiss-Prot: CAPG_HUMAN, P40121
    Tissue specificity: Macrophages and macrophage-like cells

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAPG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CAPG gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Capg1 , 5 capping protein (actin filament), gelsolin-like1, 5 89.37(n)1
    92.82(a)1
      6 (32.27 cM)5
    123321  NM_007599.41  NP_031625.21 
     725443915 
    chicken
    (Gallus gallus)
    Aves CAPG1 capping protein (actin filament), gelsolin-like 69.84(n)
    66.57(a)
      431244  XM_428798.4  XP_428798.3 
    lizard
    (Anolis carolinensis)
    Reptilia CAPG6
    capping protein (actin filament), gelsolin-like
    71(a)
    1 ↔ 1
    GL343238.1(227328-240778)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia capg1 capping protein (actin filament), gelsolin-like 55.33(n)
    51.74(a)
      496747  NM_001011294.1  NP_001011294.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb14e072 Danio rerio, Similar to capping protein (actin filament), more 75.35(n)    BC049461.1 


    ENSEMBL Gene Tree for CAPG (if available)
    TreeFam Gene Tree for CAPG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CAPG gene
    SVIL2  FLII2  VILL2  AVIL2  SCIN2  GSN2  VIL12  
    7 SIMAP similar genes for CAPG using alignment to 4 protein entries:     CAPG_HUMAN (see all proteins):
    DKFZp313L0718    GSN    AVIL    SCIN    VIL1    VILL
    FLII

    Find genes that share paralogs with CAPG           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CAPG (see all 520)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs719777631,2
    C--85531622(+) TCTCA-/AAAAAA 3 -- int10--------
    rs1459187931,2
    C--85621429(+) AGTGGC/TCCTGG 3 -- int10--------
    rs760973521,2
    C--85621572(+) GCATCC/TGAAGA 3 -- int14Minor allele frequency- T:0.05CSA WA NA EA 360
    rs753820211,2
    C,F--85621573(+) CATCCG/AAAGAA 3 -- int11Minor allele frequency- A:0.05EA 120
    rs1115232741,2
    C--85621945(+) ACTGAC/TCAGGC 3 -- ut310--------
    rs3700428271,2
    C--85622008(+) AAGACA/GCCCAC 3 -- ut310--------
    rs68861,2,,4
    C,F,H--85622059(-) GGGCCA/GTGAGA 6 H R mis1 ese334Minor allele frequency- N:0.00EA MN NA NS WA CSA EU 9665
    rs1923927301,2
    --85622157(+) GGGGGA/CCAGAG 3 -- int10--------
    rs116906501,2
    C,F,A,H--85622317(+) ATAAAC/TGCCAC 3 -- int128Minor allele frequency- N:0.00EA NA NS WA CSA 2982
    rs1384025781,2
    --85622327(+) CCAACA/GGTAGC 3 -- int10--------

    HapMap Linkage Disequilibrium report for CAPG (85621871 - 85645555 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CAPG:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834283CNV Loss17160897
    nsv834282CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CAPG
    DNA2.0 Custom Variant and Variant Library Synthesis for CAPG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 153615    OMIM disorders: --


    Find genes that share disorders with CAPG           About GenesLikeMe

    1 Novoseek inferred disease relationship for CAPG gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 8.5 10 18059028 (2), 18237446 (2), 15454578 (1), 18461482 (1) (see all 5)

    Genetic Association Database (GAD): CAPG
    Human Genome Epidemiology (HuGE) Navigator: CAPG (2 documents)

    Export disorders for CAPG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CAPG gene, integrated from 10 sources (see all 56):
    (articles sorted by number of sources associating them with CAPG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages. (PubMed id 1322908)1, 2, 3, 9 Dabiri G.A.... Southwick F.S. (J. Biol. Chem. 1992)
    2. Cap G, a gelsolin family protein modulating protective effects of unidirectional shear stress. (PubMed id 12754261)1, 3, 9 Pellieux C....Silacci P. (J. Biol. Chem. 2003)
    3. The human actin-regulatory protein cap G: gene structure and chromosome location. (PubMed id 7851883)1, 2, 9 Mishra V.S.... Southwick F.S. (Genomics 1994)
    4. Proteomic study of macrophages exposed to oxLDL identifies a CAPG polymorphism associated with carotid atherosclerosis. (PubMed id 19439302)1, 4 Burillo E....Civeira F. (Atherosclerosis 2009)
    5. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (J. Proteome Res. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Gain-of-function mutations conferring actin-severing activity to human macrophage cap G. (PubMed id 7814409)1, 2 Southwick F.S. (J. Biol. Chem. 1995)
    8. Clinical significance of gelsolin-like actin-capping protein expression in oral carcinogenesis: an immunohistochemical study of premalignant and malignant lesions of the oral cavity. (PubMed id 18237446)1, 9 Nomura H....Tanzawa H. (BMC Cancer 2008)
    9. Increased importin-beta-dependent nuclear import of the actin modulating protein CapG promotes cell invasion. (PubMed id 15454578)1, 9 De Corte V....Gettemans J. (J. Cell. Sci. 2004)
    10. A new role for nuclear transport factor 2 and Ran: nuclear import of CapG. (PubMed id 18266911)1, 9 Van Impe K....Gettemans J. (Traffic 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 822 HGNC: 1474 AceView: CAPG Ensembl:ENSG00000042493 euGenes: HUgn822
    ECgene: CAPG H-InvDB: CAPG

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CAPG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CAPG Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CAPG gene:
    Search GeneIP for patents involving CAPG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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