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Aliases for CAPG Gene

Aliases for CAPG Gene

  • Capping Actin Protein, Gelsolin Like 2 3 5
  • Capping Protein (Actin Filament), Gelsolin-Like 2 3
  • AFCP 3 4
  • MCP 3 4
  • Epididymis Secretory Protein Li 66 3
  • Actin-Regulatory Protein CAP-G 3
  • Actin Regulatory Protein CAP-G 4
  • Gelsolin-Like Capping Protein 3
  • Macrophage Capping Protein 2
  • Macrophage-Capping Protein 3
  • HEL-S-66 3

External Ids for CAPG Gene

Previous HGNC Symbols for CAPG Gene

  • AFCP

Previous GeneCards Identifiers for CAPG Gene

  • GC02M085517
  • GC02M085915
  • GC02M085579
  • GC02M085596
  • GC02M085533
  • GC02M085475
  • GC02M085621
  • GC02M085520

Summaries for CAPG Gene

Entrez Gene Summary for CAPG Gene

  • This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for CAPG Gene

CAPG (Capping Actin Protein, Gelsolin Like) is a Protein Coding gene. GO annotations related to this gene include actin binding and protein complex binding. An important paralog of this gene is GSN.

UniProtKB/Swiss-Prot for CAPG Gene

  • Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.

Gene Wiki entry for CAPG Gene

Additional gene information for CAPG Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAPG Gene

Genomics for CAPG Gene

Regulatory Elements for CAPG Gene

Enhancers for CAPG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H085404 1.7 FANTOM5 Ensembl ENCODE dbSUPER 27 +10.1 10067 8 HDGF EGR1 RCOR1 RUNX3 IKZF2 EGR2 SMARCA5 ZNF362 CEBPB ELF1 CAPG RETSAT TGOLN2 KCMF1 LOC105374841 ENSG00000273196
GH02H085412 1.7 FANTOM5 ENCODE dbSUPER 26.3 +4.5 4478 2 PKNOX1 FOXA2 ATF1 MLX ARID4B SIN3A TCF12 ZNF766 GATA2 ELK1 CAPG RETSAT TGOLN2 VAMP8 LOC105374841 ENSG00000273196
GH02H085417 1.4 ENCODE dbSUPER 26.9 -1.9 -1917 5 MLX ZFP64 DMAP1 SLC30A9 ZNF143 SP3 NFYC PPARGC1A MEF2D SSRP1 SNORD94 CAPG ELMOD3 MAT2A TCF7L1 USP39 POLR1A SH2D6 GC02P085438
GH02H085392 1.1 ENCODE dbSUPER 28.7 +25.3 25301 3 HDGF PKNOX1 RB1 TBL1XR1 NFIB ARID4B RAD21 GLIS2 ZNF143 MIXL1 CAPG ENSG00000273196 LOC105374841
GH02H085395 0.9 ENCODE dbSUPER 29.2 +21.4 21396 2 SOX13 SMARCE1 ESRRA ZNF687 DPF2 SREBF1 ZNF217 CTBP1 JUND GATA3 CAPG RETSAT ENSG00000273196 LOC105374841
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CAPG on UCSC Golden Path with GeneCards custom track

Genomic Location for CAPG Gene

Chromosome:
2
Start:
85,394,748 bp from pter
End:
85,418,467 bp from pter
Size:
23,720 bases
Orientation:
Minus strand

Genomic View for CAPG Gene

Genes around CAPG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAPG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAPG Gene

Proteins for CAPG Gene

  • Protein details for CAPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40121-CAPG_HUMAN
    Recommended name:
    Macrophage-capping protein
    Protein Accession:
    P40121
    Secondary Accessions:
    • B8ZZS7
    • D6W5K8
    • Q53SA7

    Protein attributes for CAPG Gene

    Size:
    348 amino acids
    Molecular mass:
    38499 Da
    Quaternary structure:
    • Interacts with NUP62 (PubMed:18266911). Interacts with NUTF2 and RAN; involved in CAPG nuclear import (PubMed:18266911).

    Three dimensional structures from OCA and Proteopedia for CAPG Gene

    Alternative splice isoforms for CAPG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAPG Gene

Post-translational modifications for CAPG Gene

Antibody Products

No data available for DME Specific Peptides for CAPG Gene

Domains & Families for CAPG Gene

Gene Families for CAPG Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CAPG Gene

Suggested Antigen Peptide Sequences for CAPG Gene

Graphical View of Domain Structure for InterPro Entry

P40121

UniProtKB/Swiss-Prot:

CAPG_HUMAN :
  • Belongs to the villin/gelsolin family.
Family:
  • Belongs to the villin/gelsolin family.
genes like me logo Genes that share domains with CAPG: view

Function for CAPG Gene

Molecular function for CAPG Gene

GENATLAS Biochemistry:
CapG,macrophage capping protein (gelsolin/villin family of actin regulatory protein)
UniProtKB/Swiss-Prot Function:
Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.

Phenotypes From GWAS Catalog for CAPG Gene

Gene Ontology (GO) - Molecular Function for CAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18266911
GO:0019904 protein domain specific binding IPI 18266911
GO:0032403 protein complex binding IDA 18266911
GO:0045296 cadherin binding IDA 25468996
GO:0051015 actin filament binding IEA --
genes like me logo Genes that share ontologies with CAPG: view
genes like me logo Genes that share phenotypes with CAPG: view

Animal Models for CAPG Gene

MGI Knock Outs for CAPG:

Animal Model Products

CRISPR Products

miRNA for CAPG Gene

miRTarBase miRNAs that target CAPG

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CAPG
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAPG Gene

Localization for CAPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAPG Gene

Nucleus. Cytoplasm. Secreted. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Redistributes throughout the cytoplasm during mitosis and is excluded from regions containing chromosomes (By similarity). {ECO:0000250 UniProtKB:P24452, ECO:0000269 PubMed:17081065}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAPG gene
Compartment Confidence
extracellular 5
cytoskeleton 5
nucleus 5
cytosol 3
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005634 nucleus IDA 18266911
GO:0005654 nucleoplasm IDA 18938132
GO:0005730 nucleolus IDA 18938132
GO:0005737 cytoplasm IDA,IEA 18266911
genes like me logo Genes that share ontologies with CAPG: view

Pathways & Interactions for CAPG Gene

No Data Available

Gene Ontology (GO) - Biological Process for CAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly NAS 1322908
GO:0022617 NOT extracellular matrix disassembly IMP 24236012
GO:0051016 barbed-end actin filament capping IEA --
GO:0051693 actin filament capping IEA --
GO:0071803 NOT positive regulation of podosome assembly IMP 24236012
genes like me logo Genes that share ontologies with CAPG: view

No data available for Pathways by source and SIGNOR curated interactions for CAPG Gene

Drugs & Compounds for CAPG Gene

(2) Drugs for CAPG Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vincristine Approved, Investigational Pharma Microtubule disrupter,antitumor agent 954
calcium Nutra 0

(1) Additional Compounds for CAPG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CAPG: view

Transcripts for CAPG Gene

Unigene Clusters for CAPG Gene

Capping protein (actin filament), gelsolin-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CAPG
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CAPG Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
SP1: - - -
SP2: -
SP3: - - - -
SP4: - -
SP5: - -
SP6: -
SP7: -
SP8: -
SP9:

Relevant External Links for CAPG Gene

GeneLoc Exon Structure for
CAPG
ECgene alternative splicing isoforms for
CAPG

Expression for CAPG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAPG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAPG Gene

This gene is overexpressed in Whole Blood (x9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CAPG Gene



Protein tissue co-expression partners for CAPG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CAPG Gene:

CAPG

SOURCE GeneReport for Unigene cluster for CAPG Gene:

Hs.516155

mRNA Expression by UniProt/SwissProt for CAPG Gene:

P40121-CAPG_HUMAN
Tissue specificity: Macrophages and macrophage-like cells.

Evidence on tissue expression from TISSUES for CAPG Gene

  • Skin(4.8)
  • Bone marrow(4.4)
  • Liver(4.4)
  • Lung(3.4)
  • Nervous system(2.5)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with CAPG: view

Primer Products

No data available for Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAPG Gene

Orthologs for CAPG Gene

This gene was present in the common ancestor of animals.

Orthologs for CAPG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAPG 33 34
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia CAPG 33 34
  • 91.19 (n)
mouse
(Mus musculus)
Mammalia Capg 33 16 34
  • 89.37 (n)
rat
(Rattus norvegicus)
Mammalia Capg 33
  • 88.31 (n)
cow
(Bos Taurus)
Mammalia CAPG 33 34
  • 87.74 (n)
oppossum
(Monodelphis domestica)
Mammalia CAPG 34
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAPG 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves CAPG 33 34
  • 69.84 (n)
lizard
(Anolis carolinensis)
Reptilia CAPG 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia capg 33
  • 55.33 (n)
zebrafish
(Danio rerio)
Actinopterygii capgb 33 34
  • 61.86 (n)
capga 34
  • 55 (a)
OneToMany
wufb14e07 33
worm
(Caenorhabditis elegans)
Secernentea K06A4.3 35
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6001 34
  • 5 (a)
OneToMany
Species where no ortholog for CAPG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAPG Gene

ENSEMBL:
Gene Tree for CAPG (if available)
TreeFam:
Gene Tree for CAPG (if available)

Paralogs for CAPG Gene

Paralogs for CAPG Gene

(7) SIMAP similar genes for CAPG Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CAPG: view

Variants for CAPG Gene

Sequence variations from dbSNP and Humsavar for CAPG Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000123860 -- 85,412,532(+) ATAAC(-/AAT)AATAA intron-variant, upstream-variant-2KB
rs1000170206 -- 85,407,953(+) CCTCT(A/G)GCCTT intron-variant
rs1000201222 -- 85,407,521(+) CAGCC(C/T)GGGCA intron-variant
rs1000344355 -- 85,398,034(+) TATAG(A/G)TCTTG reference, missense
rs1000526352 -- 85,409,524(+) TAGGT(C/T)TCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAPG Gene

Variant ID Type Subtype PubMed ID
nsv834282 CNV gain 17160897
nsv834283 CNV loss 17160897

Variation tolerance for CAPG Gene

Residual Variation Intolerance Score: 62.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.22; 52.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAPG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAPG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAPG Gene

Disorders for CAPG Gene

Relevant External Links for CAPG

Genetic Association Database (GAD)
CAPG
Human Genome Epidemiology (HuGE) Navigator
CAPG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAPG

No disorders were found for CAPG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAPG Gene

Publications for CAPG Gene

  1. Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages. (PMID: 1322908) Dabiri GA … Southwick FS (The Journal of biological chemistry 1992) 2 3 4 22 60
  2. A new role for nuclear transport factor 2 and Ran: nuclear import of CapG. (PMID: 18266911) Van Impe K … Gettemans J (Traffic (Copenhagen, Denmark) 2008) 3 4 22 60
  3. Cap G, a gelsolin family protein modulating protective effects of unidirectional shear stress. (PMID: 12754261) Pellieux C … Silacci P (The Journal of biological chemistry 2003) 2 3 22 60
  4. The human actin-regulatory protein cap G: gene structure and chromosome location. (PMID: 7851883) Mishra VS … Southwick FS (Genomics 1994) 3 4 22 60
  5. Proteomic study of macrophages exposed to oxLDL identifies a CAPG polymorphism associated with carotid atherosclerosis. (PMID: 19439302) Burillo E … Civeira F (Atherosclerosis 2009) 3 45 60

Products for CAPG Gene

Sources for CAPG Gene

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