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Aliases for CAP2 Gene

Aliases for CAP2 Gene

  • Cyclase Associated Actin Cytoskeleton Regulatory Protein 2 2 3 5
  • CAP 2 3 4
  • CAP, Adenylate Cyclase-Associated Protein, 2 (Yeast) 2
  • CAP, Adenylate Cyclase-Associated Protein, 2 3
  • Adenylyl Cyclase-Associated Protein 2 3
  • 2810452G09Rik 3

External Ids for CAP2 Gene

Previous GeneCards Identifiers for CAP2 Gene

  • GC06P017451
  • GC06P017501
  • GC06P017340

Summaries for CAP2 Gene

Entrez Gene Summary for CAP2 Gene

  • This gene was identified by its similarity to the gene for human adenylyl cyclase-associated protein. The function of the protein encoded by this gene is unknown. However, the protein appears to be able to interact with adenylyl cyclase-associated protein and actin. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAP2 Gene

CAP2 (Cyclase Associated Actin Cytoskeleton Regulatory Protein 2) is a Protein Coding gene. Among its related pathways are Ectoderm Differentiation and Signaling by Robo receptor. GO annotations related to this gene include actin binding. An important paralog of this gene is CAP1.

UniProtKB/Swiss-Prot for CAP2 Gene

  • May have a regulatory bifunctional role.

Gene Wiki entry for CAP2 Gene

Additional gene information for CAP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAP2 Gene

Genomics for CAP2 Gene

Regulatory Elements for CAP2 Gene

Enhancers for CAP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H017392 1.3 ENCODE dbSUPER 39.5 +0.9 948 3.2 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ETS1 CAP2 NUP153 LOC105374952 LOC101928491
GH06H017389 1.1 ENCODE dbSUPER 38.3 -2.5 -2546 3.1 PKNOX1 ESRRA ATF1 SIN3A CEBPG NFXL1 RFX5 CTBP1 GATA3 FOSL2 CAP2 LOC100421092
GH06H017276 1.7 FANTOM5 Ensembl ENCODE dbSUPER 21.2 -112.9 -112914 7.6 ZFP64 SIN3A RAD21 GLIS2 SCRT2 FOS CEBPB MAFF ZNF341 KDM1A CAP2 RBM24 STMND1 LOC101928463
GH06H017415 1 Ensembl ENCODE dbSUPER 29 +24.5 24498 4.3 GATA3 POLR2A CEBPA SIN3A FOS CAP2 LOC101928491
GH06H017470 1.7 VISTA Ensembl ENCODE dbSUPER 16.7 +79.8 79801 4.8 PKNOX1 ARNT FEZF1 ZNF2 ZNF121 JUNB TSHZ1 GLIS1 MYNN WT1 CAP2 LOC101928491
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CAP2 on UCSC Golden Path with GeneCards custom track

Promoters for CAP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Transcription factor binding sites by QIAGEN in the CAP2 gene promoter:

Genomic Locations for CAP2 Gene

Genomic Locations for CAP2 Gene
164,577 bases
Plus strand

Genomic View for CAP2 Gene

Genes around CAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAP2 Gene

Proteins for CAP2 Gene

  • Protein details for CAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adenylyl cyclase-associated protein 2
    Protein Accession:
    Secondary Accessions:
    • B2R5Y3
    • B7Z1C4
    • B7Z214
    • Q6IAY2

    Protein attributes for CAP2 Gene

    477 amino acids
    Molecular mass:
    52824 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CAP2 Gene


neXtProt entry for CAP2 Gene

Post-translational modifications for CAP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CAP2 Gene

Domains & Families for CAP2 Gene

Gene Families for CAP2 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CAP family.
  • Belongs to the CAP family.
genes like me logo Genes that share domains with CAP2: view

Function for CAP2 Gene

Molecular function for CAP2 Gene

UniProtKB/Swiss-Prot Function:
May have a regulatory bifunctional role.

Phenotypes From GWAS Catalog for CAP2 Gene

Gene Ontology (GO) - Molecular Function for CAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA,IBA --
GO:0005515 protein binding IPI 25416956
GO:0008179 adenylate cyclase binding IBA --
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with CAP2: view
genes like me logo Genes that share phenotypes with CAP2: view

Animal Models for CAP2 Gene

MGI Knock Outs for CAP2:
  • Cap2 tm1a(EUCOMM)Wtsi
  • Cap2 tm1e(EUCOMM)Wtsi
  • Cap2 tm1b(EUCOMM)Wtsi

Animal Model Products

CRISPR Products

miRNA for CAP2 Gene

miRTarBase miRNAs that target CAP2

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAP2 Gene

Localization for CAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAP2 Gene

Cell membrane; Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAP2 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 4
cytosol 4
nucleus 3
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane IEA --
GO:0030864 cortical actin cytoskeleton IBA --
genes like me logo Genes that share ontologies with CAP2: view

Pathways & Interactions for CAP2 Gene

genes like me logo Genes that share pathways with CAP2: view

Pathways by source for CAP2 Gene

Gene Ontology (GO) - Biological Process for CAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IBA --
GO:0007010 cytoskeleton organization IEA --
GO:0007163 establishment or maintenance of cell polarity TAS 7962207
GO:0007165 signal transduction TAS 7962207
GO:0007190 activation of adenylate cyclase activity TAS 7962207
genes like me logo Genes that share ontologies with CAP2: view

No data available for SIGNOR curated interactions for CAP2 Gene

Drugs & Compounds for CAP2 Gene

No Compound Related Data Available

Transcripts for CAP2 Gene

Unigene Clusters for CAP2 Gene

CAP, adenylate cyclase-associated protein, 2 (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAP2 Gene

No ASD Table

Relevant External Links for CAP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAP2 Gene

This gene is overexpressed in Muscle - Skeletal (x13.7).

Protein differential expression in normal tissues from HIPED for CAP2 Gene

This gene is overexpressed in Frontal cortex (12.8), Lung (11.4), and Fetal heart (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CAP2 Gene

Protein tissue co-expression partners for CAP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CAP2 Gene:


SOURCE GeneReport for Unigene cluster for CAP2 Gene:


Evidence on tissue expression from TISSUES for CAP2 Gene

  • Nervous system(4.9)
  • Liver(4.2)
  • Muscle(2.4)
genes like me logo Genes that share expression patterns with CAP2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAP2 Gene

Orthologs for CAP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CAP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CAP2 33 34
  • 99.65 (n)
(Bos Taurus)
Mammalia CAP2 33 34
  • 89.01 (n)
(Canis familiaris)
Mammalia CAP2 33 34
  • 88.47 (n)
(Monodelphis domestica)
Mammalia CAP2 34
  • 86 (a)
(Mus musculus)
Mammalia Cap2 33 16 34
  • 85.08 (n)
(Rattus norvegicus)
Mammalia Cap2 33
  • 83.89 (n)
(Ornithorhynchus anatinus)
Mammalia CAP2 34
  • 82 (a)
(Gallus gallus)
Aves CAP2 33 34
  • 76.03 (n)
(Anolis carolinensis)
Reptilia CAP2 34
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cap2 33
  • 70.45 (n)
(Danio rerio)
Actinopterygii cap2 33 34
  • 64.86 (n)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta capt 35 34
  • 48 (a)
(Caenorhabditis elegans)
Secernentea cah-1 35
  • 46 (a)
cas-1 35 34
  • 46 (a)
F41G4.2a 35
  • 46 (a)
cas-2 34
  • 35 (a)
C18E3.6 35
  • 32 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR061W 33
  • 45.36 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRV2 34 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.162 34
  • 36 (a)
Species where no ortholog for CAP2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAP2 Gene

Gene Tree for CAP2 (if available)
Gene Tree for CAP2 (if available)

Paralogs for CAP2 Gene

Paralogs for CAP2 Gene

(2) SIMAP similar genes for CAP2 Gene using alignment to 7 proteins: Pseudogenes for CAP2 Gene

genes like me logo Genes that share paralogs with CAP2: view

Variants for CAP2 Gene

Sequence variations from dbSNP and Humsavar for CAP2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000003228 -- 17,468,525(+) AGCAC(C/G)TTTCT intron-variant
rs1000043829 -- 17,526,149(+) GTCTC(A/G)CTCTG intron-variant
rs1000047896 -- 17,537,974(+) AGGCA(A/G)GAGAA intron-variant
rs1000057237 -- 17,444,589(+) TGAGC(C/T)GAGAT intron-variant
rs1000068368 -- 17,478,282(+) GACGT(G/T)CACCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAP2 Gene

Variant ID Type Subtype PubMed ID
nsv969351 CNV duplication 23825009
nsv957548 CNV deletion 24416366
nsv823435 CNV loss 20364138
nsv601046 CNV gain 21841781
nsv5214 CNV deletion 18451855
nsv516012 CNV gain+loss 19592680
nsv472444 CNV novel sequence insertion 20440878
nsv349497 CNV deletion 16902084
nsv1147478 CNV deletion 26484159
nsv1114781 CNV deletion 24896259
nsv1072219 CNV deletion 25765185
nsv1027813 CNV gain 25217958
esv993176 CNV deletion 20482838
esv8324 CNV loss 19470904
esv4873 CNV loss 18987735
esv3608212 CNV loss 21293372
esv3436619 CNV insertion 20981092
esv3426081 CNV insertion 20981092
esv28379 CNV loss 19812545
esv2731632 CNV deletion 23290073
esv2731631 CNV deletion 23290073
esv2662516 CNV deletion 23128226
esv2642821 CNV deletion 19546169
esv2519333 CNV deletion 19546169
esv2486925 CNV deletion 19546169
esv2337248 CNV deletion 18987734
esv2026108 CNV deletion 18987734
esv1751200 CNV deletion 17803354
esv1591451 CNV deletion 17803354
dgv5922n100 CNV gain 25217958
dgv5921n100 CNV gain 25217958
dgv380e215 CNV deletion 23714750
dgv3278n106 CNV deletion 24896259
dgv1715e212 CNV gain 25503493

Variation tolerance for CAP2 Gene

Residual Variation Intolerance Score: 19.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.54; 64.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAP2 Gene

Disorders for CAP2 Gene

Relevant External Links for CAP2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CAP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAP2 Gene

Publications for CAP2 Gene

  1. Comparison of human CAP and CAP2, homologs of the yeast adenylyl cyclase-associated proteins. (PMID: 7962207) Yu G … Young D (Journal of cell science 1994) 2 3 4 22 60
  2. Mammalian CAP interacts with CAP, CAP2, and actin. (PMID: 8761950) Hubberstey A … Young D (Journal of cellular biochemistry 1996) 2 3 22 60
  3. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson DF … Stefansson K (Nature genetics 2008) 3 45 60
  4. Overexpression of cyclase-associated protein 2 in multistage hepatocarcinogenesis. (PMID: 17000669) Shibata R … Sakamoto M (Clinical cancer research : an official journal of the American Association for Cancer Research 2006) 3 22 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for CAP2 Gene

Sources for CAP2 Gene

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