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Aliases for CAP2 Gene

Aliases for CAP2 Gene

  • CAP, Adenylate Cyclase-Associated Protein, 2 (Yeast) 2 3 5
  • CAP 2 3 4
  • 2810452G09Rik 3

External Ids for CAP2 Gene

Previous GeneCards Identifiers for CAP2 Gene

  • GC06P017451
  • GC06P017501
  • GC06P017340

Summaries for CAP2 Gene

Entrez Gene Summary for CAP2 Gene

  • This gene was identified by its similarity to the gene for human adenylyl cyclase-associated protein. The function of the protein encoded by this gene is unknown. However, the protein appears to be able to interact with adenylyl cyclase-associated protein and actin. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAP2 Gene

CAP2 (CAP, Adenylate Cyclase-Associated Protein, 2 (Yeast)) is a Protein Coding gene. Among its related pathways are Developmental Biology and Signaling by Robo receptor. GO annotations related to this gene include actin binding. An important paralog of this gene is CAP1.

UniProtKB/Swiss-Prot for CAP2 Gene

  • May have a regulatory bifunctional role.

Gene Wiki entry for CAP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAP2 Gene

Genomics for CAP2 Gene

Regulatory Elements for CAP2 Gene

Promoters for CAP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CAP2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CAP2 gene promoter:

Genomic Location for CAP2 Gene

Chromosome:
6
Start:
17,393,216 bp from pter
End:
17,557,792 bp from pter
Size:
164,577 bases
Orientation:
Plus strand

Genomic View for CAP2 Gene

Genes around CAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAP2 Gene

Proteins for CAP2 Gene

  • Protein details for CAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40123-CAP2_HUMAN
    Recommended name:
    Adenylyl cyclase-associated protein 2
    Protein Accession:
    P40123
    Secondary Accessions:
    • B2R5Y3
    • B7Z1C4
    • B7Z214
    • Q6IAY2

    Protein attributes for CAP2 Gene

    Size:
    477 amino acids
    Molecular mass:
    52824 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAP2 Gene

Proteomics data for CAP2 Gene at MOPED

Post-translational modifications for CAP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CAP2 Gene

Domains & Families for CAP2 Gene

Graphical View of Domain Structure for InterPro Entry

P40123

UniProtKB/Swiss-Prot:

CAP2_HUMAN :
  • Contains 1 C-CAP/cofactor C-like domain.
  • Belongs to the CAP family.
Domain:
  • Contains 1 C-CAP/cofactor C-like domain.
Family:
  • Belongs to the CAP family.
genes like me logo Genes that share domains with CAP2: view

No data available for Gene Families for CAP2 Gene

Function for CAP2 Gene

Molecular function for CAP2 Gene

UniProtKB/Swiss-Prot Function:
May have a regulatory bifunctional role.

Gene Ontology (GO) - Molecular Function for CAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with CAP2: view
genes like me logo Genes that share phenotypes with CAP2: view

Animal Models for CAP2 Gene

MGI Knock Outs for CAP2:
  • Cap2 tm1b(EUCOMM)Wtsi

Animal Model Products

  • Taconic Biosciences Mouse Models for CAP2

miRNA for CAP2 Gene

miRTarBase miRNAs that target CAP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAP2 Gene

Localization for CAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAP2 Gene

Cell membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAP2 Gene COMPARTMENTS Subcellular localization image for CAP2 gene
Compartment Confidence
cytosol 4
plasma membrane 4
nucleus 3
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for CAP2 Gene

Pathways & Interactions for CAP2 Gene

genes like me logo Genes that share pathways with CAP2: view

Pathways by source for CAP2 Gene

Gene Ontology (GO) - Biological Process for CAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IEA --
GO:0007010 cytoskeleton organization IEA --
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with CAP2: view

No data available for SIGNOR curated interactions for CAP2 Gene

Drugs & Compounds for CAP2 Gene

No Compound Related Data Available

Transcripts for CAP2 Gene

Unigene Clusters for CAP2 Gene

CAP, adenylate cyclase-associated protein, 2 (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAP2 Gene

No ASD Table

Relevant External Links for CAP2 Gene

GeneLoc Exon Structure for
CAP2
ECgene alternative splicing isoforms for
CAP2

Expression for CAP2 Gene

mRNA expression in normal human tissues for CAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAP2 Gene

This gene is overexpressed in Muscle - Skeletal (x13.7).

Protein differential expression in normal tissues from HIPED for CAP2 Gene

This gene is overexpressed in Frontal cortex (12.8), Lung (11.4), and Fetal heart (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAP2 Gene



SOURCE GeneReport for Unigene cluster for CAP2 Gene Hs.132902

genes like me logo Genes that share expression patterns with CAP2: view

Protein tissue co-expression partners for CAP2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CAP2 Gene

Orthologs for CAP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CAP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CAP2 35
  • 89.01 (n)
  • 90.97 (a)
CAP2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAP2 35
  • 88.47 (n)
  • 89.73 (a)
CAP2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cap2 35
  • 85.08 (n)
  • 89.08 (a)
Cap2 16
Cap2 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CAP2 35
  • 99.65 (n)
  • 99.16 (a)
CAP2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cap2 35
  • 83.89 (n)
  • 87.61 (a)
oppossum
(Monodelphis domestica)
Mammalia CAP2 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAP2 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves CAP2 35
  • 76.03 (n)
  • 80.71 (a)
CAP2 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAP2 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cap2 35
  • 70.45 (n)
  • 70.38 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
cap2 35
  • 64.86 (n)
  • 63.64 (a)
cap2 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta capt 37
  • 48 (a)
capt 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C18E3.6 37
  • 32 (a)
cah-1 37
  • 46 (a)
cas-1 37
  • 46 (a)
F41G4.2a 37
  • 46 (a)
cas-1 36
  • 15 (a)
ManyToMany
cas-2 36
  • 35 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR061W 35
  • 45.36 (n)
  • 35.65 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRV2 36
  • 31 (a)
OneToMany
SRV2 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.162 36
  • 36 (a)
OneToMany
Species with no ortholog for CAP2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAP2 Gene

ENSEMBL:
Gene Tree for CAP2 (if available)
TreeFam:
Gene Tree for CAP2 (if available)

Paralogs for CAP2 Gene

Paralogs for CAP2 Gene

(2) SIMAP similar genes for CAP2 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for CAP2 Gene

genes like me logo Genes that share paralogs with CAP2: view

Variants for CAP2 Gene

Sequence variations from dbSNP and Humsavar for CAP2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs34620829 - 17,541,077(+) GTCCC(A/G)CATCT reference, missense
rs34206659 - 17,541,093(+) ATCTT(A/G)TCCTT reference, missense
rs9256 -- 17,543,071(+) TGTAA(A/G)AAACT reference, synonymous-codon
rs707859 -- 17,497,260(+) AAAGC(A/T)CAAGT intron-variant
rs714399 -- 17,466,678(-) TCAGC(A/G)GCACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAP2 Gene

Variant ID Type Subtype PubMed ID
nsv349497 CNV Loss 16902084
esv270064 CNV Insertion 20981092
esv274666 CNV Insertion 20981092
nsv5214 CNV Loss 18451855
esv2486925 CNV Deletion 19546169
esv2337248 CNV Deletion 18987734
esv2662516 CNV Deletion 23128226
esv2731631 CNV Deletion 23290073
esv28379 CNV Loss 19812545
esv1591451 CNV Deletion 17803354
nsv823435 CNV Loss 20364138
nsv516012 CNV Gain+Loss 19592680
esv2642821 CNV Deletion 19546169
esv2026108 CNV Deletion 18987734
esv2731632 CNV Deletion 23290073
esv4873 CNV Deletion 18987735
esv993176 CNV Deletion 20482838
esv2519333 CNV Deletion 19546169
esv1751200 CNV Deletion 17803354
esv8324 CNV Loss 19470904
nsv883455 CNV Gain 21882294
nsv883456 CNV Gain 21882294
nsv883457 CNV Gain 21882294
nsv883458 CNV Gain 21882294

Variation tolerance for CAP2 Gene

Residual Variation Intolerance Score: 19.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.54; 64.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAP2 Gene

HapMap Linkage Disequilibrium report
CAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAP2 Gene

Disorders for CAP2 Gene

Relevant External Links for CAP2

Genetic Association Database (GAD)
CAP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAP2

No disorders were found for CAP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAP2 Gene

Publications for CAP2 Gene

  1. Comparison of human CAP and CAP2, homologs of the yeast adenylyl cyclase-associated proteins. (PMID: 7962207) Yu G. … Young D. (J. Cell Sci. 1994) 2 3 4 23 67
  2. Mammalian CAP interacts with CAP, CAP2, and actin. (PMID: 8761950) Hubberstey A. … Young D. (J. Cell. Biochem. 1996) 2 3 23
  3. Overexpression of cyclase-associated protein 2 in multistage hepatocarcinogenesis. (PMID: 17000669) Shibata R. … Sakamoto M. (Clin. Cancer Res. 2006) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. (PMID: 24797263) Tong J. … Moran M.F. (Mol. Cell Proteomics 2014) 3

Products for CAP2 Gene

Sources for CAP2 Gene

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