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CAP2 Gene

protein-coding   GIFtS: 57
GCID: GC06P017393

CAP, Adenylate Cyclase-Associated Protein, 2 (Yeast)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CAP, Adenylate Cyclase-Associated Protein, 2 (Yeast)1 2
CAP 22 3
2810452G09Rik2
Adenylyl Cyclase-Associated Protein 22
PI85
SERPINB85

External Ids:    HGNC: 200391   Entrez Gene: 104862   Ensembl: ENSG000001121867   OMIM: 6016975   UniProtKB: P401233   

Export aliases for CAP2 gene to outside databases

Previous GC identifers: GC06P017451 GC06P017501 GC06P017340


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CAP2 Gene:
This gene was identified by its similarity to the gene for human adenylyl cyclase-associated protein. The function
of the protein encoded by this gene is unknown. However, the protein appears to be able to interact with adenylyl
cyclase-associated protein and actin. (provided by RefSeq, Jul 2008)

GeneCards Summary for CAP2 Gene:
CAP2 (CAP, adenylate cyclase-associated protein, 2 (yeast)) is a protein-coding gene. Diseases associated with CAP2 include tongue cancer, and hepatocellular carcinoma. GO annotations related to this gene include actin binding. An important paralog of this gene is CAP1.

UniProtKB/Swiss-Prot: CAP2_HUMAN, P40123
Function: May have a regulatory bifunctional role

Gene Wiki entry for CAP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CAP2 gene promoter:
         ATF-2   E4BP4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCAP2 promoter sequence
   Search Chromatin IP Primers for CAP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.3   Ensembl cytogenetic band:  6p22.3   HGNC cytogenetic band: 6p22.3

CAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAP2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P017393:  view genomic region     (about GC identifiers)

Start:
17,393,447 bp from pter      End:
17,558,023 bp from pter
Size:
164,577 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CAP2_HUMAN, P40123 (See protein sequence)
Recommended Name: Adenylyl cyclase-associated protein 2  
Size: 477 amino acids; 52824 Da
Secondary accessions: B2R5Y3 Q6IAY2

Explore the universe of human proteins at neXtProt for CAP2: NX_P40123

Explore proteomics data for CAP2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CAP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006357.1  
    ENSEMBL proteins: 
     ENSP00000229922   ENSP00000417705   ENSP00000368275   ENSP00000417208   ENSP00000420615  
     ENSP00000418604   ENSP00000419906  
    Reactome Protein details: P40123

    CAP2 Human Recombinant Protein Products:

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    Novus Biologicals CAP2 Protein
    Novus Biologicals CAP2 Lysate
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    Cloud-Clone Corp. Proteins for CAP2

    CAP2 Antibody Products:

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    Abcam antibodies for CAP2
    Cloud-Clone Corp. Antibodies for CAP2
    Search ThermoFisher Antibodies for CAP2
    LSBio Antibodies in human, mouse, rat for CAP2

    CAP2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CAP2
    Cloud-Clone Corp. CLIAs for CAP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 9):
     IPR028418 CAP2
     IPR001837 Adenylate_cyclase-assoc_CAP
     IPR013992 Adenylate_cyclase-assoc_CAP_N
     IPR017901 C-CAP_CF_C-like
     IPR016098 CAP/MinC_C

    Graphical View of Domain Structure for InterPro Entry P40123

    ProtoNet protein and cluster: P40123

    2 Blocks protein domains:
    IPB001837 CAP protein
    IPB006599 Cyclase-associated protein


    UniProtKB/Swiss-Prot: CAP2_HUMAN, P40123
    Similarity: Belongs to the CAP family
    Similarity: Contains 1 C-CAP/cofactor C-like domain


    CAP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAP2_HUMAN, P40123
    Function: May have a regulatory bifunctional role

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
         
    CAP2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CAP2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CAP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAP2

    miRNA
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    Block miRNA regulation of human, mouse, rat CAP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CAP2 (see all 9):
    hsa-miR-3910 hsa-miR-548p hsa-miR-135b hsa-miR-582-5p hsa-miR-2276 hsa-miR-15b* hsa-miR-3119 hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidCAP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CAP2
    Predesigned siRNA for gene silencing in human, mouse, rat CAP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CAP2

    Clone
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    OriGene clones in human, mouse for CAP2 (see all 6)
    OriGene ORF clones in mouse, rat for CAP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CAP2 (NM_006366)
    Sino Biological Human cDNA Clone for CAP2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAP2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CAP2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CAP2_HUMAN, P40123: Cell membrane; Peripheral membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    cytoskeleton1
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--

    CAP2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CAP2 About    
    See pathways by source

    SuperPathContained pathways About
    1L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    2Signaling by Robo receptor
    Signaling by Robo receptor
    Role of Abl in Robo-Slit signaling0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for CAP2
        Role of Abl in Robo-Slit signaling



    CAP2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CAP2
    Interactions:

        Search GeneGlobe Interaction Network for CAP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CAP2 (P401232, 3 ENSP000002299224) via UniProtKB, MINT, STRING, and/or I2D (see all 179)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRPF40AO754002, 3MINT-61869 I2D: score=3 
    ENSG00000206324Q999433, ENSP000003827234I2D: score=3 STRING: ENSP00000382723
    ENSG00000228892Q999433, ENSP000004128054I2D: score=3 STRING: ENSP00000412805
    ENSG00000235758Q999433, ENSP000004012874I2D: score=3 STRING: ENSP00000401287
    AGPAT1Q999433, ENSP000003374634I2D: score=3 STRING: ENSP00000337463
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ----
    GO:0007010cytoskeleton organization IEA--
    GO:0007163establishment or maintenance of cell polarity TAS7962207
    GO:0007165signal transduction TAS7962207
    GO:0007190activation of adenylate cyclase activity TAS7962207

    CAP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CAP2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CAP2 gene: 
    NM_006366.2  

    Unigene Cluster for CAP2:

    CAP, adenylate cyclase-associated protein, 2 (yeast)
    Hs.132902  [show with all ESTs]
    Unigene Representative Sequence: NM_006366
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000229922(uc010jpk.1 uc003ncb.3 uc011dja.2 uc011djb.2 uc011djc.2 uc011djd.2)
    ENST00000489374 ENST00000378990 ENST00000493172 ENST00000479291 ENST00000465994
    ENST00000476263
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CAP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CAP2 (see all 9):
    hsa-miR-3910 hsa-miR-548p hsa-miR-135b hsa-miR-582-5p hsa-miR-2276 hsa-miR-15b* hsa-miR-3119 hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidCAP2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CAP2
    Predesigned siRNA for gene silencing in human, mouse, rat CAP2
    Clone
    Products:
         
    OriGene clones in human, mouse for CAP2 (see all 6)
    OriGene ORF clones in mouse, rat for CAP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CAP2 (NM_006366)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAP2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CAP2
    OriGene qSTAR qPCR primer pairs in human, mouse for CAP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CAP2
      QuantiTect SYBR Green Assays in human, mouse, rat CAP2
      QuantiFast Probe-based Assays in human, mouse, rat CAP2

    Additional mRNA sequence: 

    AK293134.1 AK294215.1 AK295600.1 AK297538.1 AK308461.1 AK312362.1 AL832154.1 BC008481.1 
    CR457022.1 U02390.1 

    10 DOTS entries:

    DT.115804  DT.92442448  DT.101979588  DT.95108858  DT.121380640  DT.86837933  DT.95327992  DT.100660316 
    DT.100787999  DT.100788002 

    Selected AceView cDNA sequences (see all 232):

    BP348444 AI671183 NM_006366 BC008481 AA045873 BU521331 AI468733 BE670582 
    AW130810 BU930998 BM712984 CB117578 F04191 AA031399 AW444984 AV727249 
    AI754419 CD693274 BQ024464 BU508073 BE217938 AU123318 F28199 BQ228045 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CAP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCAAGGTT
    CAP2 Expression
    About this image


    CAP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Neurons
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Skeletal Muscle (Muscoskeletal System)
    CAP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CAP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.132902
        Custom PCR Arrays for CAP2
    Primer
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    OriGene qPCR primer pairs and template standards for CAP2
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    QuantiFast Probe-based Assays in human, mouse, rat CAP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CAP2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cap21 , 5 CAP, adenylate cyclase-associated protein, 2 (yeast)1, 5 85.08(n)1
    89.08(a)1
      13 (23.83 cM)5
    672521  NM_026056.41  NP_080332.11 
     465018485 
    chicken
    (Gallus gallus)
    Aves CAP21 CAP, adenylate cyclase-associated protein, 2 (yeast) 76.03(n)
    80.71(a)
      420847  XM_004939640.1  XP_004939697.1 
    lizard
    (Anolis carolinensis)
    Reptilia CAP26
    CAP, adenylate cyclase-associated protein, 2 (yeas...
    74(a)
    1 ↔ 1
    4(59033261-59103965)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cap21 CAP, adenylate cyclase-associated protein, 2 (yeast) 70.45(n)
    70.38(a)
      100490411  XM_002932680.2  XP_002932726.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC060935.12   -- 73.33(n)   393809  BC060935.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta capt3 actin filament organization actin
    binding
    48(a)   21F2   --
    worm
    (Caenorhabditis elegans)
    Secernentea F41G4.2a3 adenylyl cyclase-associated protein 46(a)
    (best of 4)
      X(16838477-16844453)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SRV2(YNL138W)4 CAP (cyclase-associated protein) subunit of adenylyl more   --   14(366741-368321) 855584  NP_014261.1 


    ENSEMBL Gene Tree for CAP2 (if available)
    TreeFam Gene Tree for CAP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CAP2 gene
    CAP12  
    2 SIMAP similar genes for CAP2 using alignment to 7 protein entries:     CAP2_HUMAN (see all proteins):
    DKFZp686D0714    CAP1

    CAP2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CAP2
    PGOHUM00000247881


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CAP2 (see all 3481)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs9749481,2
    C,A,H--17391759(+) GTCCAA/GTTGGA 1 -- us2k110Minor allele frequency- G:0.49MN WA NA CSA EA 551
    rs1846789831,2
    --17391773(+) TATGGA/GCAATA 1 -- us2k10--------
    rs9749491,2
    C,F,A,H--17391785(+) GTATCA/CAAGAG 1 -- us2k119Minor allele frequency- C:0.21MN NS EA WA NA CSA 2514
    rs766853921,2
    C,F--17391905(+) GGCTCG/ATTACT 1 -- us2k11Minor allele frequency- A:0.06WA 118
    rs1408210921,2
    --17391949(+) GATTTC/TCCTGC 1 -- us2k10--------
    rs119651991,2
    C,F,A,H--17391992(+) CCAAAC/TTAACC 1 -- us2k19Minor allele frequency- T:0.41NA WA CSA EA 368
    rs119683121,2
    C,F,H--17391999(+) AACCAT/CTGCTA 1 -- us2k16Minor allele frequency- C:0.49NA WA CSA 127
    rs21434471,2
    C,F,A--17392039(+) TCCCCC/AAGTGC 1 -- us2k19Minor allele frequency- A:0.20NA WA CSA EA 370
    rs1899493731,2
    --17392098(+) CAGCCA/GGGGCC 1 -- us2k10--------
    rs69374631,2
    C,F,A--17392147(+) TCCAGC/GTAAAC 1 -- us2k18Minor allele frequency- G:0.19WA NA CSA EA 368

    HapMap Linkage Disequilibrium report for CAP2 (17393447 - 17558023 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CAP2 (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2642821CNV Deletion19546169
    esv1751200CNV Deletion17803354
    esv2731631CNV Deletion23290073
    esv2026108CNV Deletion18987734
    esv2486925CNV Deletion19546169
    esv2337248CNV Deletion18987734
    esv2519333CNV Deletion19546169
    esv993176CNV Deletion20482838
    esv2731632CNV Deletion23290073
    esv4873CNV Deletion18987735

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CAP2
    DNA2.0 Custom Variant and Variant Library Synthesis for CAP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601697    OMIM disorders: --

    4 diseases for CAP2:    
    About MalaCards
    tongue cancer    hepatocellular carcinoma    cerebritis    endotheliitis


    CAP2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CAP2

    Export disorders for CAP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CAP2 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with CAP2)
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    1. Comparison of human CAP and CAP2, homologs of the yeast adenylyl cyclase-associated proteins. (PubMed id 7962207)1, 2, 3, 9 Yu G.... Young D. (J. Cell Sci. 1994)
    2. Mammalian CAP interacts with CAP, CAP2, and actin. (PubMed id 8761950)1, 3, 9 Hubberstey A....Young D. (J. Cell. Biochem. 1996)
    3. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Overexpression of cyclase-associated protein 2 in multistage hepatocarcinogenesis. (PubMed id 17000669)1, 9 Shibata R....Sakamoto M. (Clin. Cancer Res. 2006)
    6. Involvement of hepatocellular carcinoma biomarker, cyclase-associated protein 2 in zebrafish body development and cancer progression. (PubMed id 23022774)1 Effendi K....Sakamoto M. (Exp. Cell Res. 2013)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    9. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    10. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10486 HGNC: 20039 AceView: CAP2 Ensembl:ENSG00000112186 euGenes: HUgn10486
    ECgene: CAP2 H-InvDB: CAP2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CAP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CAP2 gene:
    Search GeneIP for patents involving CAP2

    GeneCards and IP:
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