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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CAP1 Gene

protein-coding   GIFtS: 60
GCID: GC01P040505

CAP, Adenylate Cyclase-Associated Protein 1 (Yeast)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CAP, Adenylate Cyclase-Associated Protein 1 (Yeast)1 2
CAP2 3
CAP 12 3
CAP1-PEN2
Adenylyl Cyclase-Associated Protein 12
SSKAP555

External Ids:    HGNC: 200401   Entrez Gene: 104872   Ensembl: ENSG000001312367   OMIM: 6049695   UniProtKB: Q015183   

Export aliases for CAP1 gene to outside databases

Previous GC identifers: GC01P039969 GC01P039920 GC01P039921 GC01P040175 GC01P040278 GC01P038624


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CAP1 Gene:
The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP
pathway. The human protein is able to interact with other molecules of the same protein, as well as with CAP2 and
actin. Alternatively spliced transcript variants have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for CAP1 Gene: 
CAP1 (CAP, adenylate cyclase-associated protein 1 (yeast)) is a protein-coding gene. Diseases associated with CAP1 include tongue cancer, and beta thalassemia, and among its related super-pathways are Response to elevated platelet cytosolic Ca2+ and Axon guidance. GO annotations related to this gene include actin binding. An important paralog of this gene is CAP2.

UniProtKB/Swiss-Prot: CAP1_HUMAN, Q01518
Function: Directly regulates filament dynamics and has been implicated in a number of complex developmental and
morphological processes, including mRNA localization and the establishment of cell polarity

Gene Wiki entry for CAP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CAP1 gene promoter:
         Pbx1a   AML1a   p300   CUTL1   CREB   AREB6   MZF-1   deltaCREB   Pax-4a   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCAP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CAP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.2   Ensembl cytogenetic band:  1p34.2   HGNC cytogenetic band: 1p34.3

CAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAP1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P040505:  view genomic region     (about GC identifiers)

Start:
40,505,905 bp from pter      End:
40,538,321 bp from pter
Size:
32,417 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CAP1_HUMAN, Q01518 (See protein sequence)
Recommended Name: Adenylyl cyclase-associated protein 1  
Size: 475 amino acids; 51901 Da
Subunit: Homodimer. Binds actin monomers
Subcellular location: Cell membrane; Peripheral membrane protein (By similarity)
1 PDB 3D structure from and Proteopedia for CAP1:
1K8F (3D)    
Secondary accessions: Q53HR7 Q5T0S1 Q5T0S2 Q6I9U6
Alternative splicing: 2 isoforms:  Q01518-1   Q01518-2   

Explore the universe of human proteins at neXtProt for CAP1: NX_Q01518

Explore proteomics data for CAP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q01518

  • CAP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CAP1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001099000.1  NP_006358.1  

    ENSEMBL proteins: 
     ENSP00000361883   ENSP00000361888   ENSP00000398475   ENSP00000403198   ENSP00000398877  
     ENSP00000408561   ENSP00000410586   ENSP00000361878   ENSP00000361884   ENSP00000344832  
     ENSP00000361891   ENSP00000412859   ENSP00000413656   ENSP00000400943   ENSP00000413383  
     ENSP00000389974  
    Reactome Protein details: Q01518
    Human Recombinant Protein Products for CAP1: 
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    OriGene Purified Protein for CAP1
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    Novus Biologicals CAP1 Protein
    Novus Biologicals CAP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CAP1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane IEA--
    GO:0030864cortical actin cytoskeleton IEA--

    CAP1 for ontologies           About GeneDecksing



    CAP1 Antibody Products: 
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    ThermoFisher Antibodies for CAP1
    LSBio Antibodies in human, mouse, rat for CAP1 

    Assay Products for CAP1: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CAP1 
    Cloud-Clone Corp. CLIAs for CAP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR001837 Adenylate_cyclase-assoc_CAP
     IPR013992 Adenylate_cyclase-assoc_CAP_N
     IPR017901 C-CAP_CF_C-like
     IPR016098 CAP/MinC_C
     IPR018106 CAP_CS

    Graphical View of Domain Structure for InterPro Entry Q01518

    ProtoNet protein and cluster: Q01518

    2 Blocks protein domains:
    IPB001837 CAP protein
    IPB006599 Cyclase-associated protein


    UniProtKB/Swiss-Prot: CAP1_HUMAN, Q01518
    Similarity: Belongs to the CAP family
    Similarity: Contains 1 C-CAP/cofactor C-like domain


    CAP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAP1_HUMAN, Q01518
    Function: Directly regulates filament dynamics and has been implicated in a number of complex developmental and
    morphological processes, including mRNA localization and the establishment of cell polarity

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding ----
         
    CAP1 for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for CAP1:
     Increased Salmonella enterica   Increased Salmonella enterica   Increased Salmonella enterica   Increased Salmonella enterica  
     Increased Salmonella enterica   Increased Salmonella-containin  Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CAP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CAP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAP1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CAP1:
    hsa-mir-1 (MIRT002798)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAP1
    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate CAP1 (see all 47):
    hsa-let-7d hsa-miR-513a-5p hsa-miR-1260b hsa-miR-3916 hsa-let-7g hsa-miR-548m hsa-miR-9 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidCAP1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CAP1

    Clone
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    GenScript: all cDNA clones in your preferred vector: CAP1 (NM_014716)
    Browse Sino Biological Human cDNA Clones
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                         Customized lentivirus expression plasmids for stable overexpression of CAP1 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CAP1 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Platelet degranulation
    Platelet degranulation 0.94
    Response to elevated platelet cytosolic Ca2+0.94
    2Axon guidance
    Axon guidance0.69
    Developmental Biology0.69
    3Platelet activation, signaling and aggregation
    Platelet activation, signaling and aggregation0.43
    Hemostasis0.43
    4Activation of Rac
    Signaling by Robo receptor0.44
    5Role of Abl in Robo-Slit signaling
    Role of Abl in Robo-Slit signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CAP1
        Insulin Signaling

    5/8        Reactome Pathways for CAP1 (see all 8)
        Hemostasis
    Developmental Biology
    Platelet degranulation
    Role of Abl in Robo-Slit signaling
    Signaling by Robo receptor



    CAP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/70 Interacting proteins for CAP1 (Q015183 ENSP000003618784) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAP2P401233, ENSP000002299224I2D: score=3 STRING: ENSP00000229922
    ABL2P426843, ENSP000003565954I2D: score=1 STRING: ENSP00000356595
    ACTBP607093, ENSP000003499604I2D: score=1 STRING: ENSP00000349960
    CFL1P235283, ENSP000003096294I2D: score=1 STRING: ENSP00000309629
    MYOCQ999723, ENSP000000375024I2D: score=1 STRING: ENSP00000037502
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ----
    GO:0001667ameboidal cell migration IEA--
    GO:0002576platelet degranulation TAS--
    GO:0006898receptor-mediated endocytosis IEA--
    GO:0007010cytoskeleton organization ----

    CAP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CAP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CAP1

    1 Novoseek inferred chemical compound relationship for CAP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclic amp 32.9 4 1406678 (1), 17951520 (1)

    Search CenterWatch for drugs/clinical trials and news about CAP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CAP1 gene (2 alternative transcripts): 
    NM_001105530.1  NM_006367.3  

    Unigene Cluster for CAP1:

    CAP, adenylate cyclase-associated protein 1 (yeast)
    Hs.370581  [show with all ESTs]
    Unigene Representative Sequence: NM_006367
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000372797(uc001cfa.4 uc001cey.4 uc001cez.4 uc009vvz.3 uc010oje.2)
    ENST00000372802 ENST00000449311 ENST00000421589(uc010ojd.1) ENST00000414893
    ENST00000414281 ENST00000420216 ENST00000372792 ENST00000372798 ENST00000340450
    ENST00000372805 ENST00000435719 ENST00000427843 ENST00000417287 ENST00000424977
    ENST00000446031 ENST00000479759 ENST00000461993
    miRNA
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    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate CAP1 (see all 47):
    hsa-let-7d hsa-miR-513a-5p hsa-miR-1260b hsa-miR-3916 hsa-let-7g hsa-miR-548m hsa-miR-9 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidCAP1 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAP1
    Clone
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    OriGene clones in human, mouse for CAP1 (see all 13)
    OriGene ORF clones in mouse, rat for CAP1
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    GenScript: all cDNA clones in your preferred vector: CAP1 (NM_014716)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAP1
    Sirion Biotech Customized lentivirus for stable overexpression of CAP1 
                         Customized lentivirus expression plasmids for stable overexpression of CAP1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CAP1
    OriGene qSTAR qPCR primer pairs in human, mouse for CAP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CAP1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAP1

    Additional mRNA sequence: 

    AK096193.1 AK222513.1 AK295396.1 AK297829.1 AK298094.1 AK298110.1 AK300861.1 AK315731.1 
    BC013963.2 BC020367.1 BC095440.1 BT007152.1 BX537801.1 CR457409.1 L12168.1 M98474.1 

    24/72 DOTS entries (see all 72):

    DT.100059795  DT.92464595  DT.92464576  DT.444472  DT.102842132  DT.96085130  DT.420521  DT.121410048 
    DT.100690341  DT.91850925  DT.100690352  DT.100769585  DT.100690349  DT.92464645  DT.95303264  DT.100690354 
    DT.121410268  DT.92385067  DT.100847303  DT.121410265  DT.97869858  DT.100690347  DT.97857134  DT.102842131 

    24/1000 AceView cDNA sequences (see all 1000):

    AI468320 BP381733 CA421289 BU177374 BP362262 BM557495 BE275310 BM477512 
    AU077003 BQ424412 BU172993 BG684107 BM462861 AA489356 CF541366 BE255381 
    BE907686 W57898 BE299158 BE909603 BU857455 AI754582 AI002798 BM473386 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CAP1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                    -                                       
    SP3:                                            -     -     -     -     -     -     -     -     -     -     -           -                                       
    SP4:                    -                                                                                                                                       
    SP5:                                                                                -     -     -     -                 -                                       

    ExUns: 13a · 13b ^ 14a · 14b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for CAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CAP1 expression in normal human tissues (normalized intensities)      CAP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCATCAGCT
    CAP1 Expression
    About this image


    CAP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Limb Bud Mesenchyme Cells Limb Bud
             Limb Bud
     
     Bone (Muscoskeletal System)
             Mandibular Condyle
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
     
     Mesoderm (Gastrulation Derivatives)
             Limb Bud Mesenchyme Cells Limb Bud

    See CAP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CAP1

    SOURCE GeneReport for Unigene cluster: Hs.370581
        SABiosciences Expression via Pathway-Focused PCR Array including CAP1: 
              Insulin Signaling Pathway in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CAP1 gene from 10/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cap11 , 5 CAP, adenylate cyclase-associated protein 1 (yeast)1, 5 90.65(n)1
    95.57(a)1
      4 (57.27 cM)5
    123311  NM_007598.31  NP_031624.21 
     1228590475 
    chicken
    (Gallus gallus)
    Aves CAP11 CAP, adenylate cyclase-associated protein 1 (yeast) 73.11(n)
    78.13(a)
      419680  XM_003642584.1  XP_003642632.1 
    lizard
    (Anolis carolinensis)
    Reptilia CAP16
    Adenylyl cyclase-associated protein
    76(a)
    1 ↔ 1
    GL343498.1(211396-233838)
    African clawed frog
    (Xenopus laevis)
    Amphibia CAP1b2 cyclase-associated protein 1b 77.25(n)    AY233268.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj98f012 wufj98f01 79.17(n)   334527  AY162326.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta capt1 capulet 56.16(n)
    52.37(a)
      45233  NM_001038781.1  NP_001033870.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cas-11 Protein CAS-1 48.93(n)
    41.24(a)
      181729  NM_078312.2  NP_510713.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SRV21 Srv2p 47.41(n)
    38.17(a)
      855584   NP_014261.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CAP11 cyclase associated protein 1 47.54(n)
    40.85(a)
      829600  NM_119614.5  NP_195175.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g04479001 hypothetical protein 47.51(n)
    39.49(a)
      4345716  NM_001068469.1  NP_001061934.1 


    ENSEMBL Gene Tree for CAP1 (if available)
    TreeFam Gene Tree for CAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CAP1 gene
    CAP22  
    2 SIMAP similar genes for CAP1 using alignment to 13 protein entries:     CAP1_HUMAN (see all proteins):
    DKFZp686D0714    CAP2

    CAP1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CAP1
    PGOHUM00000262843 PGOHUM00000238079


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/773 SNPs in CAP1 are shown (see all 773)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0284214
    ----see VAR_0284212 I S mis40--------
    VAR_0284194
    ----see VAR_0284192 C G mis40--------
    VAR_0284244
    ----see VAR_0284242 S A mis40--------
    VAR_0284224
    ----see VAR_0284222 C G mis40--------
    VAR_0284204
    ----see VAR_0284202 C G mis40--------
    rs775389851,2
    C--40512153(+) AAAAC-/AAAAAA 2 -- int11Minor allele frequency- A:0.00CSA 2
    rs105616601,2
    C--40517068(+) CACAT-/ACACACA 2 -- int10--------
    rs612758651,2
    C--40527895(+) GGAGACTCT/-  
            
    CTCTT
    2 -- int11Minor allele frequency- -:0.50CSA 2
    rs106024881,2
    C--40534503(+) TTATTTTTTA/
            
    TTTTA
    2 -- int11Minor allele frequency- -:0.50CSA 2
    rs1474357591,2
    --40581918(+) CGCCTC/TGGCCT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CAP1 (40505905 - 40538321 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CAP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv267524CNV Insertion20981092
    nsv588CNV Insertion18451855
    esv2750836CNV Gain17911159
    nsv517028CNV Gain19592680
    dgv49e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604969    OMIM disorders: --

    7 diseases for CAP1:    About MalaCards
    tongue cancer    beta thalassemia    thalassemia    pancreatic cancer
    pancreatitis    hepatocellular carcinoma    gastric cancer


    CAP1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CAP1
    Human Genome Epidemiology (HuGE) Navigator: CAP1 (3 documents)

    Export disorders for CAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CAP1 gene, integrated from 9 sources (see all 66):
    (articles sorted by number of sources associating them with CAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a human cDNA encoding a protein that is structurally and functionally related to the yeast adenylyl cyclase- associated CAP proteins. (PubMed id 1406678)1, 2, 3, 9 Matviw H.... Young D. (1992)
    2. Mammalian CAP interacts with CAP, CAP2, and actin. (PubMed id 8761950)1, 3, 9 Hubberstey A....Young D. (1996)
    3. Crystal structure of the actin binding domain of the cyclase- associated protein. (PubMed id 15311924)1, 2, 9 Dodatko T.... Almo S.C. (2004)
    4. Identification of type 2 diabetes-associated combinat ion of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (2010)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    6. Phosphoproteomic analysis of the human pituitary. (PubMed id 16807684)1, 2 Beranova-Giorgianni S.... Giorgianni F. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    9. Comparison of human CAP and CAP2, homologs of the yeast adenylyl cyclase-associated proteins. (PubMed id 7962207)1, 9 Yu G.... Young D. (1994)
    10. Human CAP1 is a key factor in the recycling of cofilin and actin for rapid actin turnover. (PubMed id 11950878)1, 9 Moriyama K. and Yahara I. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10487 HGNC: 20040 AceView: CAP1 Ensembl:ENSG00000131236 euGenes: HUgn10487
    ECgene: CAP1 H-InvDB: CAP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CAP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CAP1 gene:
    Search GeneIP for patents involving CAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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