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Aliases for CAP1 Gene

Aliases for CAP1 Gene

  • CAP, Adenylate Cyclase-Associated Protein 1 (Yeast) 2 3 5
  • CAP 1 3 4
  • CAP 3 4
  • Testis Secretory Sperm-Binding Protein Li 218p 3
  • CAP1-PEN 3

External Ids for CAP1 Gene

Previous GeneCards Identifiers for CAP1 Gene

  • GC01P039969
  • GC01P039920
  • GC01P039921
  • GC01P040175
  • GC01P040278
  • GC01P040505
  • GC01P038624

Summaries for CAP1 Gene

Entrez Gene Summary for CAP1 Gene

  • The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with other molecules of the same protein, as well as with CAP2 and actin. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAP1 Gene

CAP1 (CAP, Adenylate Cyclase-Associated Protein 1 (Yeast)) is a Protein Coding gene. Diseases associated with CAP1 include herpes simplex encephalitis 3 and pollen allergy. Among its related pathways are Developmental Biology and Platelet activation, signaling and aggregation. GO annotations related to this gene include actin binding. An important paralog of this gene is CAP2.

UniProtKB/Swiss-Prot for CAP1 Gene

  • Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.

Gene Wiki entry for CAP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAP1 Gene

Genomics for CAP1 Gene

Regulatory Elements for CAP1 Gene

Enhancers for CAP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CAP1 on UCSC Golden Path with GeneCards custom track

Promoters for CAP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CAP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CAP1 Gene

Chromosome:
1
Start:
40,040,233 bp from pter
End:
40,072,649 bp from pter
Size:
32,417 bases
Orientation:
Plus strand

Genomic View for CAP1 Gene

Genes around CAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAP1 Gene

Proteins for CAP1 Gene

  • Protein details for CAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01518-CAP1_HUMAN
    Recommended name:
    Adenylyl cyclase-associated protein 1
    Protein Accession:
    Q01518
    Secondary Accessions:
    • Q53HR7
    • Q5T0S1
    • Q5T0S2
    • Q6I9U6

    Protein attributes for CAP1 Gene

    Size:
    475 amino acids
    Molecular mass:
    51901 Da
    Quaternary structure:
    • Homodimer. Binds actin monomers.

    Three dimensional structures from OCA and Proteopedia for CAP1 Gene

    Alternative splice isoforms for CAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAP1 Gene

Proteomics data for CAP1 Gene at MOPED

Post-translational modifications for CAP1 Gene

  • Ubiquitination at Lys 412
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CAP1 Gene

Domains & Families for CAP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q01518

UniProtKB/Swiss-Prot:

CAP1_HUMAN :
  • Contains 1 C-CAP/cofactor C-like domain.
  • Belongs to the CAP family.
Domain:
  • Contains 1 C-CAP/cofactor C-like domain.
Family:
  • Belongs to the CAP family.
genes like me logo Genes that share domains with CAP1: view

No data available for Gene Families for CAP1 Gene

Function for CAP1 Gene

Molecular function for CAP1 Gene

UniProtKB/Swiss-Prot Function:
Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.

Gene Ontology (GO) - Molecular Function for CAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with CAP1: view
genes like me logo Genes that share phenotypes with CAP1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CAP1 Gene

Localization for CAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAP1 Gene

Cell membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAP1 Gene COMPARTMENTS Subcellular localization image for CAP1 gene
Compartment Confidence
extracellular 5
cytoskeleton 3
cytosol 3
plasma membrane 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CAP1: view

Pathways & Interactions for CAP1 Gene

genes like me logo Genes that share pathways with CAP1: view

Pathways by source for CAP1 Gene

Gene Ontology (GO) - Biological Process for CAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0006898 receptor-mediated endocytosis IEA --
GO:0007010 cytoskeleton organization IEA --
GO:0007411 axon guidance TAS --
GO:0030036 actin cytoskeleton organization IEA --
genes like me logo Genes that share ontologies with CAP1: view

No data available for SIGNOR curated interactions for CAP1 Gene

Drugs & Compounds for CAP1 Gene

(1) Drugs for CAP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CAP1: view

Transcripts for CAP1 Gene

Unigene Clusters for CAP1 Gene

CAP, adenylate cyclase-associated protein 1 (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAP1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^
SP1:
SP2: -
SP3: - - - - - - - - - - - -
SP4: -
SP5: - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - - -
SP8:

ExUns: 13a · 13b ^ 14a · 14b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:

Relevant External Links for CAP1 Gene

GeneLoc Exon Structure for
CAP1
ECgene alternative splicing isoforms for
CAP1

Expression for CAP1 Gene

mRNA expression in normal human tissues for CAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAP1 Gene

This gene is overexpressed in Whole Blood (x10.1).

Protein differential expression in normal tissues from HIPED for CAP1 Gene

This gene is overexpressed in Lymph node (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAP1 Gene



SOURCE GeneReport for Unigene cluster for CAP1 Gene Hs.370581

genes like me logo Genes that share expression patterns with CAP1: view

Protein tissue co-expression partners for CAP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CAP1 Gene

Orthologs for CAP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CAP1 35
  • 91.95 (n)
  • 93.86 (a)
CAP1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAP1 35
  • 93.61 (n)
  • 95.79 (a)
CAP1 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cap1 35
  • 90.65 (n)
  • 95.57 (a)
Cap1 16
Cap1 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CAP1 35
  • 99.86 (n)
  • 100 (a)
CAP1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cap1 35
  • 90.72 (n)
  • 95.78 (a)
oppossum
(Monodelphis domestica)
Mammalia CAP1 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAP1 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves CAP1 35
  • 73.46 (n)
  • 78.56 (a)
CAP1 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAP1 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cap1 35
  • 68.16 (n)
  • 71.22 (a)
Str.2788 35
African clawed frog
(Xenopus laevis)
Amphibia CAP1b 35
zebrafish
(Danio rerio)
Actinopterygii cap1 35
  • 65.08 (n)
  • 65.87 (a)
wufj98f01 35
cap1 36
  • 66 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010175 35
  • 53.25 (n)
  • 49.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta capt 35
  • 55.09 (n)
  • 51.64 (a)
capt 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cas-1 35
  • 48.36 (n)
  • 39.96 (a)
cas-1 36
  • 15 (a)
ManyToMany
cas-2 36
  • 34 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A11638g 35
  • 47.84 (n)
  • 38.35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRV2 36
  • 32 (a)
OneToMany
SRV2 35
  • 46.75 (n)
  • 37.66 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons CAP1 35
  • 47.17 (n)
  • 39.51 (a)
rice
(Oryza sativa)
Liliopsida Os08g0447900 35
  • 47.13 (n)
  • 39.07 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08008 35
  • 44.49 (n)
  • 32.61 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cap1 35
  • 48.41 (n)
  • 36.92 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.162 36
  • 38 (a)
OneToMany
Species with no ortholog for CAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAP1 Gene

ENSEMBL:
Gene Tree for CAP1 (if available)
TreeFam:
Gene Tree for CAP1 (if available)

Paralogs for CAP1 Gene

Paralogs for CAP1 Gene

Pseudogenes.org Pseudogenes for CAP1 Gene

genes like me logo Genes that share paralogs with CAP1: view

Variants for CAP1 Gene

Sequence variations from dbSNP and Humsavar for CAP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs11207440 - 40,067,594(+) GATCA(G/T)GTCCT reference, missense
rs6665926 - 40,067,615(+) CACCA(G/T)GCCCC reference, missense
rs6665933 - 40,067,643(+) TACCA(G/T)TTCAT reference, missense
rs6665936 - 40,067,648(+) TTTCA(G/T)GCTCA reference, missense
rs6665937 - 40,067,654(+) GCTCA(C/G/T)ATGAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CAP1 Gene

Variant ID Type Subtype PubMed ID
dgv49e1 CNV Complex 17122850
esv2750836 CNV Gain 17911159
nsv517028 CNV Gain 19592680
esv267524 CNV Insertion 20981092
nsv588 CNV Insertion 18451855

Variation tolerance for CAP1 Gene

Residual Variation Intolerance Score: 52.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 41.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAP1 Gene

HapMap Linkage Disequilibrium report
CAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAP1 Gene

Disorders for CAP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CAP1 Gene - From: OMIM and GeneCards

Disorder Aliases PubMed IDs
herpes simplex encephalitis 3
  • herpes simplex encephalitis, susceptibility to, 3
pollen allergy
  • hay fever
- elite association - COSMIC cancer census association via MalaCards
Search CAP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CAP1

Genetic Association Database (GAD)
CAP1
Human Genome Epidemiology (HuGE) Navigator
CAP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAP1
genes like me logo Genes that share disorders with CAP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAP1 Gene

Publications for CAP1 Gene

  1. Identification of a human cDNA encoding a protein that is structurally and functionally related to the yeast adenylyl cyclase- associated CAP proteins. (PMID: 1406678) Matviw H. … Young D. (Mol. Cell. Biol. 1992) 2 3 4 23 67
  2. Mammalian CAP interacts with CAP, CAP2, and actin. (PMID: 8761950) Hubberstey A. … Young D. (J. Cell. Biochem. 1996) 2 3 23
  3. Adenylate cyclase-associated protein 1 overexpressed in pancreatic cancers is involved in cancer cell motility. (PMID: 19188911) Yamazaki K. … Sakamoto M. (Lab. Invest. 2009) 3 23
  4. Mitochondrial shuttling of CAP1 promotes actin- and cofilin-dependent apoptosis. (PMID: 18716285) Wang C. … Field J. (J. Cell. Sci. 2008) 3 23
  5. Adenylyl cyclase-associated protein-1/CAP1 as a biological target substrate of gelatinase B/MMP-9. (PMID: 18671965) Cauwe B. … Opdenakker G. (Exp. Cell Res. 2008) 3 23

Products for CAP1 Gene

Sources for CAP1 Gene

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