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Aliases for CAP1 Gene

Aliases for CAP1 Gene

  • Cyclase Associated Actin Cytoskeleton Regulatory Protein 1 2
  • Adenylate Cyclase Associated Protein 1 2 3 5
  • CAP 3 4
  • CAP, Adenylate Cyclase-Associated Protein 1 (Yeast) 2
  • Testis Secretory Sperm-Binding Protein Li 218p 3
  • CAP, Adenylate Cyclase-Associated Protein 1 3
  • Adenylyl Cyclase-Associated Protein 1 3
  • CAP1-PEN 3
  • CAP 1 4

External Ids for CAP1 Gene

Previous GeneCards Identifiers for CAP1 Gene

  • GC01P039969
  • GC01P039920
  • GC01P039921
  • GC01P040175
  • GC01P040278
  • GC01P040505
  • GC01P038624

Summaries for CAP1 Gene

Entrez Gene Summary for CAP1 Gene

  • The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with other molecules of the same protein, as well as with CAP2 and actin. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2016]

GeneCards Summary for CAP1 Gene

CAP1 (Cyclase Associated Actin Cytoskeleton Regulatory Protein 1) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Developmental Biology. GO annotations related to this gene include actin binding. An important paralog of this gene is CAP2.

UniProtKB/Swiss-Prot for CAP1 Gene

  • Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.

Gene Wiki entry for CAP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAP1 Gene

Genomics for CAP1 Gene

Regulatory Elements for CAP1 Gene

Enhancers for CAP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G039931 1.8 FANTOM5 Ensembl ENCODE dbSUPER 21 -105.5 -105462 6.3 HDGF ATF1 FOXA2 PKNOX1 ARNT MLX CREB3L1 ARID4B YY1 TCF12 CAP1 MYCL TRIT1 PPT1 LOC105378668 ENSG00000202222 BMP8B RLF ZMPSTE24 SMAP2
GH01G040063 1.6 Ensembl ENCODE dbSUPER 18.5 +24.4 24388 3.2 PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 PPT1 CAP1 ENSG00000259943 PABPC4 ENSG00000260920 ZMPSTE24 ENSG00000231296
GH01G040013 1.3 Ensembl ENCODE dbSUPER 19.5 -25.7 -25696 3.0 HDAC1 PKNOX1 ESRRA GTF2E2 JUN FOSL1 ZNF316 GATA2 ADNP FOS CAP1 PPT1 MYCL LOC105378668 ENSG00000202222 TRIT1 HEYL ENSG00000259943 PIR32567 LOC105378669
GH01G039865 1.1 FANTOM5 dbSUPER 18.8 -174.5 -174485 0.2 HDGF CBX3 HINFP ZNF140 SALL2 CBX5 ZNF366 SMARCA5 ZNF114 ZBTB2 BMP8B ZMPSTE24 CAP1 TRIT1 PPT1 ENSG00000259943 ZFP69 RIMS3 PPIE RLF
GH01G039959 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11 -79.6 -79645 1.6 HDGF CTCF MXI1 MAX ZIC2 YY1 ZNF121 POLR2A NFYB EED MYCL CAP1 ENSG00000202222 TRIT1 LOC105378668 MFSD2A RPS2P12
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CAP1 on UCSC Golden Path with GeneCards custom track

Promoters for CAP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000005161 467 2601 CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC

Genomic Location for CAP1 Gene

Chromosome:
1
Start:
40,040,233 bp from pter
End:
40,072,649 bp from pter
Size:
32,417 bases
Orientation:
Plus strand

Genomic View for CAP1 Gene

Genes around CAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAP1 Gene

Proteins for CAP1 Gene

  • Protein details for CAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01518-CAP1_HUMAN
    Recommended name:
    Adenylyl cyclase-associated protein 1
    Protein Accession:
    Q01518
    Secondary Accessions:
    • Q53HR7
    • Q5T0S1
    • Q5T0S2
    • Q6I9U6

    Protein attributes for CAP1 Gene

    Size:
    475 amino acids
    Molecular mass:
    51901 Da
    Quaternary structure:
    • Homodimer. Binds actin monomers.

    Three dimensional structures from OCA and Proteopedia for CAP1 Gene

    Alternative splice isoforms for CAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAP1 Gene

Post-translational modifications for CAP1 Gene

  • Ubiquitination at Lys412
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CAP1 (CAP1)

No data available for DME Specific Peptides for CAP1 Gene

Domains & Families for CAP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q01518

UniProtKB/Swiss-Prot:

CAP1_HUMAN :
  • Belongs to the CAP family.
Family:
  • Belongs to the CAP family.
genes like me logo Genes that share domains with CAP1: view

No data available for Gene Families for CAP1 Gene

Function for CAP1 Gene

Molecular function for CAP1 Gene

UniProtKB/Swiss-Prot Function:
Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.

Gene Ontology (GO) - Molecular Function for CAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA,IBA --
GO:0008179 adenylate cyclase binding IBA --
genes like me logo Genes that share ontologies with CAP1: view
genes like me logo Genes that share phenotypes with CAP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CAP1 Gene

Localization for CAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAP1 Gene

Cell membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAP1 gene
Compartment Confidence
extracellular 5
lysosome 4
plasma membrane 3
cytoskeleton 3
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with CAP1: view

Pathways & Interactions for CAP1 Gene

genes like me logo Genes that share pathways with CAP1: view

Pathways by source for CAP1 Gene

1 Cell Signaling Technology pathway for CAP1 Gene

Gene Ontology (GO) - Biological Process for CAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IBA --
GO:0001667 ameboidal-type cell migration IEA --
GO:0006898 receptor-mediated endocytosis IEA --
GO:0007010 cytoskeleton organization IEA --
GO:0007163 establishment or maintenance of cell polarity TAS 1406678
genes like me logo Genes that share ontologies with CAP1: view

No data available for SIGNOR curated interactions for CAP1 Gene

Drugs & Compounds for CAP1 Gene

(1) Drugs for CAP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CAP1: view

Transcripts for CAP1 Gene

Unigene Clusters for CAP1 Gene

CAP, adenylate cyclase-associated protein 1 (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAP1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^
SP1:
SP2: -
SP3: - - - - - - - - - - - -
SP4: -
SP5: - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - - -
SP8:

ExUns: 13a · 13b ^ 14a · 14b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:

Relevant External Links for CAP1 Gene

GeneLoc Exon Structure for
CAP1
ECgene alternative splicing isoforms for
CAP1

Expression for CAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAP1 Gene

This gene is overexpressed in Whole Blood (x10.1).

Protein differential expression in normal tissues from HIPED for CAP1 Gene

This gene is overexpressed in Lymph node (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CAP1 Gene



Protein tissue co-expression partners for CAP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CAP1 Gene:

CAP1

SOURCE GeneReport for Unigene cluster for CAP1 Gene:

Hs.370581

Evidence on tissue expression from TISSUES for CAP1 Gene

  • Nervous system(5)
  • Blood(4.9)
  • Kidney(4.9)
  • Liver(4.8)
  • Skin(4.7)
  • Lung(4.3)
  • Intestine(4.2)
  • Pancreas(4)
  • Eye(3.6)
  • Spleen(2.8)
  • Stomach(2.5)
  • Bone(2.2)
  • Lymph node(2.2)
  • Bone marrow(2.1)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with CAP1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAP1 Gene

Orthologs for CAP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAP1 34 35
  • 99.86 (n)
dog
(Canis familiaris)
Mammalia CAP1 34 35
  • 93.61 (n)
cow
(Bos Taurus)
Mammalia CAP1 34 35
  • 91.95 (n)
rat
(Rattus norvegicus)
Mammalia Cap1 34
  • 90.72 (n)
mouse
(Mus musculus)
Mammalia Cap1 34 16 35
  • 90.65 (n)
oppossum
(Monodelphis domestica)
Mammalia CAP1 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAP1 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves CAP1 34 35
  • 73.46 (n)
lizard
(Anolis carolinensis)
Reptilia CAP1 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cap1 34
  • 68.16 (n)
Str.2788 34
African clawed frog
(Xenopus laevis)
Amphibia CAP1b 34
zebrafish
(Danio rerio)
Actinopterygii cap1 34 35
  • 65.08 (n)
wufj98f01 34
fruit fly
(Drosophila melanogaster)
Insecta capt 34 35
  • 55.09 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010175 34
  • 53.25 (n)
worm
(Caenorhabditis elegans)
Secernentea cas-1 34 35
  • 48.36 (n)
cas-2 35
  • 34 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A11638g 34
  • 47.84 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRV2 34 35
  • 46.75 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons CAP1 34
  • 47.17 (n)
rice
(Oryza sativa)
Liliopsida Os08g0447900 34
  • 47.13 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cap1 34
  • 48.41 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU08008 34
  • 44.49 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.162 35
  • 38 (a)
OneToMany
Species where no ortholog for CAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAP1 Gene

ENSEMBL:
Gene Tree for CAP1 (if available)
TreeFam:
Gene Tree for CAP1 (if available)

Paralogs for CAP1 Gene

Paralogs for CAP1 Gene

Pseudogenes.org Pseudogenes for CAP1 Gene

genes like me logo Genes that share paralogs with CAP1: view

Variants for CAP1 Gene

Sequence variations from dbSNP and Humsavar for CAP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs12061777 Likely benign 40,072,786(+) TAATC(C/T)TCATC downstream-variant-500B, utr-variant-3-prime
rs1057515445 Uncertain significance 40,073,042(-) AGTGT(C/T)TAAGG downstream-variant-500B, utr-variant-3-prime
rs1057515481 Uncertain significance 40,072,973(-) TATTT(A/G)AGCAT downstream-variant-500B, utr-variant-3-prime
rs1057515482 Uncertain significance 40,073,063(-) CTGGA(C/G)ATCAA downstream-variant-500B, utr-variant-3-prime
rs1057515553 Uncertain significance 40,072,760(-) GGGGG(-/G)ATGTG downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CAP1 Gene

Variant ID Type Subtype PubMed ID
esv2750836 CNV gain 17911159
esv2758933 CNV loss 17122850
esv3332178 CNV insertion 20981092
nsv517028 CNV gain 19592680
nsv588 CNV insertion 18451855
nsv945897 CNV duplication 23825009
nsv950665 CNV duplication 24416366

Variation tolerance for CAP1 Gene

Residual Variation Intolerance Score: 52.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 41.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAP1 Gene

Disorders for CAP1 Gene

Relevant External Links for CAP1

Genetic Association Database (GAD)
CAP1
Human Genome Epidemiology (HuGE) Navigator
CAP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAP1

No disorders were found for CAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAP1 Gene

Publications for CAP1 Gene

  1. Identification of a human cDNA encoding a protein that is structurally and functionally related to the yeast adenylyl cyclase- associated CAP proteins. (PMID: 1406678) Matviw H. … Young D. (Mol. Cell. Biol. 1992) 2 3 4 22 64
  2. Crystal structure of the actin binding domain of the cyclase- associated protein. (PMID: 15311924) Dodatko T. … Almo S.C. (Biochemistry 2004) 3 4 22 64
  3. Mammalian CAP interacts with CAP, CAP2, and actin. (PMID: 8761950) Hubberstey A. … Young D. (J. Cell. Biochem. 1996) 2 3 22 64
  4. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PMID: 20416077) Ban H.J. … Park K.J. (BMC Genet. 2010) 3 46 64
  5. Adenylate cyclase-associated protein 1 overexpressed in pancreatic cancers is involved in cancer cell motility. (PMID: 19188911) Yamazaki K. … Sakamoto M. (Lab. Invest. 2009) 3 22 64

Products for CAP1 Gene

Sources for CAP1 Gene

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