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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CANX Gene

protein-coding GIFtS: 70
GCID: GC05P179105

calnexin

Explore 41 diseases affiliated with
CANX via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Calnexin¹
IP90¹ ² ³
CNX¹ ²
P90¹ ²
Major Histocompatibility Complex Class I Antigen-Binding Protein P88² ³
P90¹ ²

External Ids:	HGNC: 1473¹	Entrez Gene: 821²	Ensembl: ENSG00000127022⁷	OMIM: 114217⁵	UniProtKB: P27824³

Export aliases for CANX gene to outside databases

Previous GC identifers: GC05P179238 GC05P180070 GC05P179190 GC05P179235 GC05P179058 GC05P173852

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CANX:

This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding,

endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked

glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of

protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced

transcript variants encoding the same protein have been described. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CALX_HUMAN, P27824

Function: Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It

may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems

to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins.

Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function

as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated

endocytosis at the synapse

Gene Wiki entry for CANX (Calnexin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_023133.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CANX gene promoter:
CREB AP-1 ATF-2 deltaCREB c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CANX promoter sequence

Search SABiosciences Chromatin IP Primers for CANX

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CANX

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35 Ensembl cytogenetic band: 5q35.3 HGNC cytogenetic band: 5q35

CANX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CANX gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P179105: view genomic region (about GC identifiers)

Start:	179,105,629 bp from pter	End:	179,158,642 bp from pter
Size:	53,014 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CALX_HUMAN, P27824 (See protein sequence)

Recommended Name: Calnexin precursor

Size: 592 amino acids; 67568 Da

Subunit: Interacts with MAPK3/ERK1. Interacts with KCNH2. Associates with ribosomes. Interacts with SGIP1; involved in

negative regulation of endocytosis (By similarity). The palmitoylated form interacts with the ribosome-translocon

complex component SSR1, promoting efficient folding of glycoproteins

Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Melanosome. Note=Identified

by mass spectrometry in melanosome fractions from stage I to stage IV. The palmitoylated form preferentially localizes

to the perinuclear rough ER

Secondary accessions: B2R5V8 D3DWQ3

Explore the universe of human proteins at neXtProt for CANX: NX_P27824

Post-translational modifications:

Phosphorylated at Ser-564 by MAPK3/ERK1. phosphorylation by MAPK3/ERK1 increases its association with ribosomes (By

similarity)¹

Palmitoylation by DHHC6 leads to the preferential localization to the perinuclear rough ER. It mediates the association

of calnexin with the ribosome-translocon complex (RTC) which is required for efficient folding of glycosylated

proteins¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P27824

CANX Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001019820.1 NP_001737.1

ENSEMBL proteins:

ENSP00000424341 ENSP00000424745 ENSP00000424063 ENSP00000247461 ENSP00000391646

ENSP00000425246 ENSP00000426052 ENSP00000426425 ENSP00000421813 ENSP00000421107

ENSP00000426555 ENSP00000427115 ENSP00000424740 ENSP00000421434 ENSP00000424140

ENSP00000394817 ENSP00000423588

Reactome Protein details: P27824
Human Recombinant Protein Products for CANX:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for CANX
	OriGene Purified Protein: CANX OriGene Protein Over-expression Lysate (see all 2): CANX OriGene Custom Protein Services for CANX
	GenScript Custom Purified and Recombinant Proteins Services for CANX
	Novus Biologicals CANX Proteins Novus Biologicals CANX Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CANX
	Uscn Proteins for CANX

Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	--	--
GO:0005783	endoplasmic reticulum	IDA	--
GO:0005788	endoplasmic reticulum lumen	TAS	--
GO:0005789	endoplasmic reticulum membrane	IDA	19723497
GO:0005791	rough endoplasmic reticulum	--	--

CANX for ontologies About GeneDecksing

CANX Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CANX
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for CANX (calnexin)
	OriGene Antibodies (see all 2): CANX OriGene Custom Antibody Services for CANX
	GenScript Superior Antibodies for CANX
	Novus Biologicals CANX Antibodies
	Abcam antibodies for CANX
	Uscn Antibodies for CANX
	ThermoFisher Antibody for CANX

Assay Products for CANX:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CANX
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CANX

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CANX for domains About GeneDecksing

5 InterPro domains/families:

IPR018124 Calret/calnex_CS

IPR013320 ConA-like_subgrp

IPR009033 Calreticulin/calnexin_P_dom

IPR001580 Calret/calnex

IPR008985 ConA-like_lec_gl_sf

Graphical View of Domain Structure for InterPro Entry P27824

ProtoNet protein and cluster: P27824

1 Blocks protein family: IPB001580 Calreticulin

UniProtKB/Swiss-Prot: CALX_HUMAN, P27824

Similarity: Belongs to the calreticulin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CALX_HUMAN, P27824

Function: Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It

may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems

to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins.

Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function

as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated

endocytosis at the synapse

Genatlas biochemistry entry for CANX:

calnexin,90kDa,integral membrane,calcium binding protein,chaperone,interacting with an ER-located peptide transporter

for peptide translocation into microsomes

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	17220478
GO:0030246	carbohydrate binding	--	--
GO:0034185	apolipoprotein binding	IEA	--
GO:0035255	ionotropic glutamate receptor binding	IEA	--

CANX for ontologies About GeneDecksing

Phenotypes:
4 GenomeRNAi human phenotypes for CANX:

Decreased homologous recombina

G0/1 arrest

Increased G1 DNA content

Increased gamma-H2AX phosphory

6 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Canx):

behavior/neurological	growth/size	immune system	mortality/aging	nervous system
no phenotypic analysis

CANX for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for CANX: Canx^tm1.1Den Canx^tm1Den Canx^tm1.1Osb

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CANX

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CANX Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CANX
		8/73 QIAGEN miScript miRNA Assays for microRNAs that regulate CANX (see all 73):
		hsa-miR-124* hsa-miR-323-3p hsa-miR-576-3p hsa-miR-200a hsa-miR-128 hsa-miR-138-2* hsa-miR-3909 hsa-miR-130b

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CANX (see all 7) OriGene shRNA RFP: CANX OriGene siRNA: CANX
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CANX
		Sirion Biotech Custom design and validation of potent shRNA sequences against CANX

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CANX
			Sirion Biotech Customized adenovirus for overexpression of CANX Sirion Biotech Customized adenovirus for potent knockdown of CANX

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CANX (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CANX (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CANX (NM_001024649)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CANX
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CANX

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CANX
		Search LifeMap BioReagents cell lines for CANX
		Sirion Biotech Customized stable knockdown cell line services for CANX Sirion Biotech Customized inducible knockdown cell line services for CANX Sirion Biotech Customized stable overexpressing cell line services for CANX Sirion Biotech Customized inducible overexpressing cell line services for CANX

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CANX

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Asparagine N-linked glycosylation

	Asparagine N-linked glycosylation	1.00			Metabolism of proteins	0.15
	Post-translational protein modification	0.44

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Calnexin/calreticulin cycle

Calnexin/calreticulin cycle

1.00

N-glycan trimming in the ER and Calnexin/Calreticulin cycle

0.85

Immune response Antigen presentation by MHC class I

Immune response Antigen presentation by MHC class I

1.00

Immune response_Antigen presentation by MHC class I

0.92

MHC class II antigen presentation

MHC class II antigen presentation

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CANX

Immune response Antigen presentation by MHC class I

1 Cell Signaling Technology (CST) Pathway for CANX

Translational Control

2 GeneGo (Thomson Reuters) Pathways for CANX

	Immune response Antigen presentation by MHC class I
	CFTR folding and maturation (norm and CF)

5/10 Reactome Pathways for CANX (see all 10)

	Antigen Presentation: Folding, assembly and peptide loading of class I MHC
	Asparagine N-linked glycosylation
	Calnexin/calreticulin cycle
	Adaptive Immune System
	N-glycan trimming in the ER and Calnexin/Calreticulin cycle

3 Kegg Pathways (Kegg details for CANX):

	Protein processing in endoplasmic reticulum
	Phagosome
	Antigen processing and presentation

CANX for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CANX

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/207 Interacting proteins for CANX (P27824^{1, 2, 3} ENSP00000247461⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 207)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SSR1	P43307²^,³, ENSP00000244763⁴	MINT-8381470 MINT-8381592 MINT-4546746 MINT-8381601 MINT-8381559 MINT-8381581 I2D: score=1 STRING: ENSP00000244763
OPRD1	P41143²^,³, ENSP00000234961⁴	MINT-7889342 MINT-7889483 MINT-7889460 MINT-7889449 I2D: score=1 STRING: ENSP00000234961
CALR	P27797²^,³, ENSP00000320866⁴	MINT-8361157 MINT-8361140 I2D: score=1 STRING: ENSP00000320866
TNFRSF1A	P19438²^,³, ENSP00000162749⁴	MINT-49320 I2D: score=3 STRING: ENSP00000162749
ABCA3	Q99758²^,³, ENSP00000301732⁴	MINT-7996633 I2D: score=1 STRING: ENSP00000301732

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	TAS	--
GO:0006457	protein folding	TAS	--
GO:0007568	aging	IEA	--
GO:0009306	protein secretion	TAS	8055875
GO:0018279	protein N-linked glycosylation via asparagine	TAS	--

CANX for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CANX for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CANX

1 HMDB Compound for CANX About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

2 DrugBank Compounds for CANX About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Antihemophilic Factor	AHF (see all 3)	--	target	chaperone	9607108 15213841 9525969 17139284 17899080 17016423
Tenecteplase	t- PA (see all 4)	191588-94-0	target	--	9359841

10/36 Novoseek chemical compound relationships for CANX gene (see all 36) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
castanospermine	91.6	35	11984787 (3), 8612572 (2), 14978212 (2), 9642271 (2) (see all 21)
dolichyl diphosphate	80.5	1	10794707 (1)
man9(glcnac)2	70.8	1	18524852 (1)
tunicamycin	70.7	17	16858427 (3), 17203246 (2), 8702523 (1), 9032450 (1) (see all 10)
polysaccharide	66.9	40	9020131 (3), 18803404 (3), 9348279 (2), 16039588 (2) (see all 28)
mannose	61.3	9	10801790 (2), 9065464 (1), 10671537 (1), 11278527 (1) (see all 8)
udpglucose	60.7	11	12181335 (2), 16154739 (1), 17643373 (1), 12671684 (1) (see all 6)
vtcs	59.6	2	10427085 (1), 15213841 (1)
miglustat	59.4	2	16546175 (1)
deoxymannojirimycin	57	1	8639654 (1)

Search CenterWatch for drugs/clinical trials and news about CANX / CALX

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CANX gene (2 alternative transcripts):

NM_001024649.1 NM_001746.3

Unigene Cluster for CANX:

Calnexin

Hs.567968 [show with all ESTs]

Unigene Representative Sequence: NM_001746

18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):

ENST00000514383 ENST00000502296 ENST00000504734 ENST00000247461(uc003mkk.3 uc011dgq.2)

ENST00000452673(uc011dgp.2 uc010jlb.1 uc003mkl.3) ENST00000502498

ENST00000507307 ENST00000504579 ENST00000513246 ENST00000502673 ENST00000506654

ENST00000514032 ENST00000510810 ENST00000509563 ENST00000503126 ENST00000508787

ENST00000506298 ENST00000505090

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CANX Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CANX
		8/73 QIAGEN miScript miRNA Assays for microRNAs that regulate CANX (see all 73):
		hsa-miR-124* hsa-miR-323-3p hsa-miR-576-3p hsa-miR-200a hsa-miR-128 hsa-miR-138-2* hsa-miR-3909 hsa-miR-130b

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CANX (see all 7) OriGene shRNA RFP: CANX OriGene siRNA: CANX
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CANX
		Sirion Biotech Custom design and validation of potent shRNA sequences against CANX

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CANX (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CANX (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CANX (NM_001024649)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CANX
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CANX

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CANX Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CANX
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CANX
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CANX

Additional cDNA sequence:

AF070646.1 AJ271880.1 AK129990.1 AK130080.1 AK294702.1 AK304420.1 AK312334.1 BC003552.1

BC042843.1 BC050534.1 BX537700.1 L10284.1 L18887.1 M94859.1 M98452.1 S67659.1

24/55 DOTS entries (see all 55):

DT.91889830 DT.97865395 DT.40116945 DT.450755 DT.100887015 DT.97760178 DT.100032450 DT.95093098

DT.91711926 DT.99960318 DT.100887002 DT.120874219 DT.120874237 DT.91949811 DT.95093053 DT.120874210

DT.120874223 DT.92463785 DT.100035034 DT.100886999 DT.100887008 DT.100887013 DT.120874153 DT.120874188

24/1359 AceView cDNA sequences (see all 1359):

BM450202 BU429498 AL537146 BF430977 BU685309 AJ707608 AW612892 BX343355

AA312275 AI337119 BX451536 AW193254 BE208285 BU172532 BQ639108 CD238290

BC042843 BE929419 AI050002 BM695229 BU781785 M94859 BU618179 AW576560

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CANX (see all 8) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7	^	8	^	9a	·	9b	·	9c	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15a	·	15b	^	16	^
SP1:											-		-		-		-																						-
SP2:									-		-		-		-		-						-		-		-		-										-
SP3:
SP4:											-		-		-		-		-		-		-		-
SP5:											-		-		-

ExUns:	17	^	18a	·	18b	^	19	^	20
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for CANX

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CANX expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTACTAAATG

About this image

CANX expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Cap Mesenchyme

Cap Mesenchyme Cells

Kidney

Kidney

Reproductive System

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CANX Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CANX

SOURCE GeneReport for Unigene cluster: Hs.567968

SABiosciences Expression via Pathway-Focused PCR Arrays including CANX:

Cellular Stress Responses in human mouse rat

Unfolded Protein Response in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CANX Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CANX
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CANX
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CANX

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CANX

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for CANX gene from 10/36 species (see all 36) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Canx^{1 , 5}	calnexin^{1, 5}	88.98(n)¹ 93.39(a)¹		11 (30.46 cM)⁵ 12330¹ NM_007597.3¹ NP_031623.1¹ 50294467⁵
chicken (Gallus gallus)	Aves	CANX¹	calnexin	79.71(n) 85.54(a)		416288 NM_001030620.1 NP_001025791.2
lizard (Anolis carolinensis)	Reptilia	CANX⁶	--	77(a)	1 ↔ 1	2(140338701-140365625)
African clawed frog (Xenopus laevis)	Amphibia	BC044970.1²	--	77.51(n)		BC044970.1
zebrafish (Danio rerio)	Actinopterygii	wufc27b06²	Danio rerio cDNA clone MGC63524 IMAGE3815058, complete cds less	77.37(n)		BC054903.1
fruit fly (Drosophila melanogaster)	Insecta	Cnx99A³	chaperone	61(a) (best of 3)		99A7 --
worm (Caenorhabditis elegans)	Secernentea	cnx-1^{1 , 3}	Calnexin³ Protein CNX-1¹	47(a)³ 54.54(n)¹ 44.99(a)¹		III(9886353-9888845)³ 176390¹ NM_066775.3¹ NP_499176.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	CNE1(YAL058W)⁴ CNE1¹	Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast less⁴ Cne1p¹	48.46(n)¹ 34.39(a)¹		1(37464-38972)⁴ 851241^{1, 4} NP_009343.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	CNX1¹	calnexin 1	58.2(n) 52.4(a)		836301 NM_125573.3 NP_200987.1
rice (Oryza sativa)	Liliopsida	Os.11092²	Oryza sativa (japonica cultivar-group) cDNA cloneJ023008D14, full insert sequence less	75.81(n)		AK069118.1

ENSEMBL Gene Tree for CANX (if available)
TreeFam Gene Tree for CANX (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CANX gene

CLGN² CALR3² CALR²

2 SIMAP similar genes for CANX using alignment to 15 protein entries: CALX_HUMAN (see all proteins):

CLGN CALR

CANX for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs5873662^1,2	C	--	179123955(+)	`GTATAAT/-ATGTT`	2	--	us2k¹		1		NA	2
rs115239070^1,2	F	--	179124082(+)	`GAGACG/TGGTTC`	2	--	us2k¹		1		WA	118
rs138394118^1,2		--	179124202(+)	`GTCTAC/TGGGTG`	2	--	us2k¹		0	--	--	--	--
rs143879974^1,2		--	179124425(+)	`TCCCAC/TTGAAT`	2	--	us2k¹		0	--	--	--	--
rs186991414^1,2		--	179124629(+)	`AAGTTA/GGGGCG`	2	--	us2k¹		0	--	--	--	--
rs28656195^1,2	C	--	179124673(+)	`GAGGCC/AGAGGC`	2	--	us2k¹ tfbs³		8		NA WA CSA	14
rs148377624^1,2		--	179124837(+)	`TGAGCC/TAAGAT`	2	--	us2k¹		0	--	--	--	--
rs7700775^1,2	C,A,H	--	179124853(+)	`CACTAC/GACTCC`	2	--	us2k¹		7		NA WA CSA	13
rs7721256^1,2	C,H	--	179124859(+)	`actccA/Cgcctg`	2	--	us2k¹		4		NS EA	418
rs191513642^1,2		--	179125025(+)	`TTCTAG/TTGTTT`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CANX (179105629 - 179158642 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CANX
1 CNV: 4481

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CANX for disorders           About GeneDecksing

OMIM gene information: 114217    OMIM disorders: --

20/41 diseases for CANX (see all 41):    About MalaCards

retinol binding protein nephrogenic diabetes insipidus oculocutaneous albinism diabetes insipidus

orbital melanoma albinism cystic fibrosis motor neuron disease

acute lymphoblastic leukemia lymphoblastic leukemia thymoma leukemia/lymphoma

insulin resistance cervical carcinoma hydrocephalus protein s deficiency

influenza fibrosis colon adenocarcinoma melanoma

1 disease from the University of Copenhagen DISEASES database for CANX:

Cystic fibrosis

10/16 Novoseek disease relationships for CANX gene (see all 16) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cystic fibrosis	40	4	7513695 (1), 18716059 (1), 15923638 (1)
albinism	37.1	1	15677452 (1)
shock	17.5	9	16404716 (1), 18230692 (1), 20137130 (1), 16061483 (1) (see all 6)
mastocytoma	15.2	1	10956670 (1)
influenza	14.4	4	16407314 (1), 9348279 (1), 8534914 (1), 14731400 (1)
melanoma	8.7	7	14732231 (2), 7531726 (2), 10360639 (1), 8219759 (1)
necrosis	4.99	1	9135824 (1)
tumors	3.47	8	10738909 (3), 14732231 (1), 10933198 (1), 17545629 (1) (see all 5)
metastasis	2.94	2	14685900 (1)
cancer	1.14	2	10738909 (1), 16098126 (1)

Genetic Association Database (GAD): CANX

Export disorders for CANX gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CANX gene, integrated from 9 sources (see all 457):
(articles sorted by number of sources associating them with CANX)

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Human, mouse, and rat calnexin cDNA cloning: identification of potential calcium binding motifs and gene localization to human chromosome 5. (PubMed id 8136357)^{1, 2, 3, 9} Tjoelker L.W.... Gray P.W. (1994)
The major histocompatibility complex class I antigen-binding protein p88 is the product of the calnexin gene. (PubMed id 1326756)^{1, 2, 3, 9} Galvin K.... Ozturk M. (1992)
The molecular chaperones HSP28, GRP78, endoplasmin, and calnexin exhibit strikingly different levels in quiescent keratinocytes as compared to their proliferating normal and transformed counterparts: cDNA cloning and expression of calnexin. (PubMed id 8055875)^{1, 2, 9} Honore B....Celis J.E. (1994)
Palmitoylated calnexin is a key component of the ribosome-translocon complex. (PubMed id 22314232)^{1, 2} Lakkaraju A.K.... van der Goot F.G. (2012)
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)^{1, 2} Chi A....Hunt D.F. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Mechanisms of pharmacological rescue of trafficking-defective hERG mutant channels in human long QT syndrome. (PubMed id 16361248)^{1, 2} Gong Q....Zhou Z. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. (PubMed id 12643545)^{1, 2} Basrur V.... Appella E. (2003)
Differential interaction of coagulation factor VIII and factor V with protein chaperones calnexin and calreticulin. (PubMed id 9525969)^{1, 7} Pipe S.W....Kaufman R.J. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 821	HGNC: 1473	AceView: LOC389352	Ensembl:ENSG00000127022	euGenes: HUgn821
ECgene: CANX	Kegg: 821	H-InvDB: CANX

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CANX	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Calnexin

Intellectual Property for CANX gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CANX gene:
Search GeneIP for patents involving CANX

GeneCards and IP:
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