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CANX Gene

protein-coding   GIFtS: 70
GCID: GC05P179105

Calnexin

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
calnexin1 2
Major Histocompatibility Complex Class I Antigen-Binding Protein P881 2 3
IP902 3
CNX2
P902
p903

External Ids:    HGNC: 14731   Entrez Gene: 8212   Ensembl: ENSG000001270227   OMIM: 1142175   UniProtKB: P278243   

Export aliases for CANX gene to outside databases

Previous GC identifers: GC05P179238 GC05P180070 GC05P179190 GC05P179235 GC05P179058 GC05P173852


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CANX Gene:
This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a
calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized
N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality
control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation.
Alternatively spliced transcript variants encoding the same protein have been described. (provided by RefSeq, Jul
2008)

GeneCards Summary for CANX Gene:
CANX (calnexin) is a protein-coding gene. Diseases associated with CANX include orbital melanoma, and nephrogenic diabetes insipidus. GO annotations related to this gene include apolipoprotein binding and calcium ion binding. An important paralog of this gene is CLGN.

UniProtKB/Swiss-Prot: CALX_HUMAN, P27824
Function: Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic
reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein
subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of
incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of
immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may
play a role in receptor-mediated endocytosis at the synapse

Gene Wiki entry for CANX (Calnexin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_023133.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the CANX gene promoter:
         CREB   AP-1   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCANX promoter sequence
   Search Chromatin IP Primers for CANX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CANX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35

CANX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CANX gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P179105:  view genomic region     (about GC identifiers)

Start:
179,105,629 bp from pter      End:
179,158,642 bp from pter
Size:
53,014 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CALX_HUMAN, P27824 (See protein sequence)
Recommended Name: Calnexin precursor  
Size: 592 amino acids; 67568 Da
Subunit: Interacts with MAPK3/ERK1. Interacts with KCNH2. Associates with ribosomes. Interacts with SGIP1;
involved in negative regulation of endocytosis (By similarity). The palmitoylated form interacts with the
ribosome-translocon complex component SSR1, promoting efficient folding of glycoproteins. Interacts with
SERPINA2P/SERPINA2 and with the S and Z variants of SERPINA1. Part of a complex which includes CANX, DERL1,
DERL2, DDOST/OST48, RPN1, RPN2, SELK, STT3A, VCP AND VIMP
Secondary accessions: B2R5V8 D3DWQ3

Explore the universe of human proteins at neXtProt for CANX: NX_P27824

Explore proteomics data for CANX at MOPED

Post-translational modifications: 

  • Phosphorylated at Ser-564 by MAPK3/ERK1. phosphorylation by MAPK3/ERK1 increases its association with ribosomes
    (By similarity)1
  • Palmitoylation by DHHC6 leads to the preferential localization to the perinuclear rough ER. It mediates the
    association of calnexin with the ribosome-translocon complex (RTC) which is required for efficient folding of
    glycosylated proteins1
  • Ubiquitination2 at Lys103, Lys118, Lys137, Lys170, Lys182, Lys227, Lys398, Lys401, Lys515
  • Glycosylation2 at Thr59, Thr66, Thr79
  • Modification sites at PhosphoSitePlus

  • See CANX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001019820.1  NP_001737.1  

    ENSEMBL proteins: 
     ENSP00000424341   ENSP00000424745   ENSP00000424063   ENSP00000247461   ENSP00000391646  
     ENSP00000425246   ENSP00000426052   ENSP00000426425   ENSP00000421813   ENSP00000421107  
     ENSP00000426555   ENSP00000427115   ENSP00000424740   ENSP00000421434   ENSP00000424140  
     ENSP00000394817   ENSP00000423588  
    Reactome Protein details: P27824

    CANX Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for CANX
    OriGene Purified Proteins for CANX
    OriGene Protein Over-expression Lysate for CANX
    OriGene MassSpec for CANX
    OriGene Custom Protein Services for CANX
    GenScript Custom Purified and Recombinant Proteins Services for CANX
    Novus Biologicals CANX Proteins
    Novus Biologicals CANX Lysates
    Sino Biological Recombinant Protein for CANX
    Sino Biological Cell Lysate for CANX
    ProSpec Recombinant Protein for CANX
    Browse Proteins at Cloud-Clone Corp.

    CANX Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CANX
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CANX  (calnexin)
    OriGene Antibodies for CANX
    OriGene Custom Antibody Services for CANX
    Novus Biologicals CANX Antibodies
    Abcam antibodies for CANX
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for CANX
    LSBio Antibodies in human, mouse, rat for CANX

    CANX Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CANX
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CANX
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR018124 Calret/calnex_CS
     IPR013320 ConA-like_subgrp
     IPR009033 Calreticulin/calnexin_P_dom
     IPR001580 Calret/calnex
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry P27824

    ProtoNet protein and cluster: P27824

    1 Blocks protein domain: IPB001580 Calreticulin

    UniProtKB/Swiss-Prot: CALX_HUMAN, P27824
    Similarity: Belongs to the calreticulin family


    CANX for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CALX_HUMAN, P27824
    Function: Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic
    reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein
    subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of
    incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of
    immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may
    play a role in receptor-mediated endocytosis at the synapse

         Genatlas biochemistry entry for CANX:
    calnexin,90kDa,integral membrane,calcium binding protein,chaperone,interacting with an ER-located peptide
    transporter for peptide translocation into microsomes

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001948glycoprotein binding IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI16361248
    GO:0034185apolipoprotein binding IEA--
    GO:0035255ionotropic glutamate receptor binding IEA--
         
    CANX for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CANX:
     Decreased homologous recombina  G0/1 arrest  Increased G1 DNA content  Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Canx):
     behavior/neurological  growth/size/body  immune system  mortality/aging  nervous system 
     no phenotypic analysis 

    CANX for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CANX: Canxtm1.1Den Canxtm1Den Canxtm1.1Osb

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CANX
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CANX

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CANX
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CANX

    miRNA
    Products:
        
    miRTarBase miRNAs that target CANX:
    hsa-mir-30e-5p (MIRT044143), hsa-mir-615-3p (MIRT040022), hsa-mir-342-3p (MIRT043681), hsa-mir-877-3p (MIRT037113), hsa-mir-18a-5p (MIRT050692), hsa-mir-185-5p (MIRT045334), hsa-mir-222-3p (MIRT046689), hsa-mir-196a-5p (MIRT048231), hsa-mir-17-5p (MIRT050869), hsa-mir-935 (MIRT036689), hsa-mir-320a (MIRT044560)

    Block miRNA regulation of human, mouse, rat CANX using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CANX (see all 73):
    hsa-miR-124* hsa-miR-323-3p hsa-miR-576-3p hsa-miR-200a hsa-miR-128 hsa-miR-138-2* hsa-miR-3909 hsa-miR-130b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CANX
    Predesigned siRNA for gene silencing in human, mouse, rat CANX

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CANX

    Clone
    Products:
         
    OriGene clones in human, mouse for CANX (see all 14)
    OriGene ORF clones in mouse, rat for CANX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CANX (NM_001024649)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CANX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CANX

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CANX
    Browse ESI BIO Cell Lines and PureStem Progenitors for CANX 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CANX


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CALX_HUMAN, P27824: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum.
    Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. The
    palmitoylated form preferentially localizes to the perinuclear rough ER
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytosol2
    golgi apparatus2
    plasma membrane2
    vacuole2
    cytoskeleton1
    endosome1
    extracellular1
    lysosome1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005783endoplasmic reticulum IDA--
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0005789endoplasmic reticulum membrane IDA19723497
    GO:0005840ribosome IEA--

    CANX for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CANX About   (see all 15)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Asparagine N-linked glycosylation0.49
    Calnexin/calreticulin cycle0.00
    Post-translational protein modification0.43
    N-glycan trimming in the ER and Calnexin/Calreticulin cycle0.00
    Metabolism of proteins0.30
    2Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    3Influenza Viral RNA Transcription and Replication
    Influenza Life Cycle0.82
    Influenza Infection0.80
    4Virus Assembly and Release
    Virus Assembly and Release
    Assembly of Viral Components at the Budding Site0.00
    5CDK-mediated phosphorylation and removal of Cdc6
    Immune response Antigen presentation by MHC class I0.68

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CANX
        Translational Control

    2 GeneGo (Thomson Reuters) Pathways for CANX
        Immune response Antigen presentation by MHC class I
    CFTR folding and maturation (norm and CF)


    4 Reactome Pathways for CANX
        Assembly of Viral Components at the Budding Site
    Antigen Presentation: Folding, assembly and peptide loading of class I MHC
    Calnexin/calreticulin cycle
    MHC class II antigen presentation


    5 Kegg Pathways  (Kegg details for CANX):
        Protein processing in endoplasmic reticulum
    Phagosome
    Antigen processing and presentation
    Thyroid hormone synthesis
    HTLV-I infection


    CANX for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CANX: 
              Cellular Stress Responses in human mouse rat
              Unfolded Protein Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CANX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CANX (P278241, 2, 3 ENSP000002474614) via UniProtKB, MINT, STRING, and/or I2D (see all 303)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SSR1P433071, 2, 3, ENSP000002447634EBI-355947,EBI-714168 MINT-8381470 MINT-8381592 MINT-4546746 MINT-8381601 MINT-8381559 MINT-8381581 I2D: score=1 STRING: ENSP00000244763
    OPRD1P411431, 2, 3, ENSP000002349614EBI-355947,EBI-2624456 MINT-7889342 MINT-7889483 MINT-7889460 MINT-7889449 I2D: score=1 STRING: ENSP00000234961
    CALRP277972, 3, ENSP000003208664MINT-8361157 MINT-8361140 I2D: score=1 STRING: ENSP00000320866
    RPL12P300501, 2EBI-355947,EBI-352743 MINT-8381470 MINT-8381543 MINT-8381601
    SEC61A1P616191, 2EBI-355947,EBI-358919 MINT-8381470 MINT-8381530 MINT-8381559
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0006457protein folding TAS--
    GO:0007568aging IEA--
    GO:0009306protein secretion TAS8055875
    GO:0018279protein N-linked glycosylation via asparagine TAS--

    CANX for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CANX (CALX)

    1 HMDB Compound for CANX    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 DrugBank Compounds for CANX    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Antihemophilic FactorAHF (see all 3)--targetchaperone9607108 15213841 9525969 17139284 17899080 17016423
    Tenecteplaset- PA (see all 4)191588-94-0target--9359841

    Selected Novoseek inferred chemical compound relationships for CANX gene (see all 36)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    castanospermine 91.6 35 11984787 (3), 8612572 (2), 14978212 (2), 9642271 (2) (see all 21)
    dolichyl diphosphate 80.5 1 10794707 (1)
    man9(glcnac)2 70.8 1 18524852 (1)
    tunicamycin 70.7 17 16858427 (3), 17203246 (2), 8702523 (1), 9032450 (1) (see all 10)
    polysaccharide 66.9 40 9020131 (3), 18803404 (3), 9348279 (2), 16039588 (2) (see all 28)
    mannose 61.3 9 10801790 (2), 9065464 (1), 10671537 (1), 11278527 (1) (see all 8)
    udpglucose 60.7 11 12181335 (2), 16154739 (1), 17643373 (1), 12671684 (1) (see all 6)
    vtcs 59.6 2 10427085 (1), 15213841 (1)
    miglustat 59.4 2 16546175 (1)
    deoxymannojirimycin 57 1 8639654 (1)



    CANX for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for CANX gene (2 alternative transcripts): 
    NM_001024649.1  NM_001746.3  

    Unigene Cluster for CANX:

    Calnexin
    Hs.567968  [show with all ESTs]
    Unigene Representative Sequence: NM_001746
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000514383 ENST00000502296 ENST00000504734 ENST00000247461(uc003mkk.3 uc011dgq.2)
    ENST00000452673(uc011dgp.2 uc010jlb.1 uc003mkl.3) ENST00000502498
    ENST00000507307 ENST00000504579 ENST00000513246 ENST00000502673 ENST00000506654
    ENST00000514032 ENST00000510810 ENST00000509563 ENST00000503126 ENST00000508787
    ENST00000506298 ENST00000505090
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CANX using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CANX (see all 73):
    hsa-miR-124* hsa-miR-323-3p hsa-miR-576-3p hsa-miR-200a hsa-miR-128 hsa-miR-138-2* hsa-miR-3909 hsa-miR-130b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CANX
    Predesigned siRNA for gene silencing in human, mouse, rat CANX
    Clone
    Products:
         
    OriGene clones in human, mouse for CANX (see all 14)
    OriGene ORF clones in mouse, rat for CANX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CANX (NM_001024649)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CANX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CANX
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CANX
    OriGene qSTAR qPCR primer pairs in human, mouse for CANX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CANX
      QuantiTect SYBR Green Assays in human, mouse, rat CANX
      QuantiFast Probe-based Assays in human, mouse, rat CANX

    Additional mRNA sequence: 

    AF070646.1 AJ271880.1 AK129990.1 AK130080.1 AK294702.1 AK304420.1 AK312334.1 BC003552.1 
    BC042843.1 BC050534.1 BX537700.1 L10284.1 L18887.1 M94859.1 M98452.1 S67659.1 

    Selected DOTS entries (see all 55):

    DT.91889830  DT.97865395  DT.40116945  DT.450755  DT.100887015  DT.97760178  DT.100032450  DT.91711926 
    DT.100887002  DT.99960318  DT.120874219  DT.120874237  DT.91949811  DT.95093053  DT.95093098  DT.120874210 
    DT.120874223  DT.100035034  DT.100886999  DT.100887008  DT.120874153  DT.120874188  DT.92027265  DT.92463793 

    Selected AceView cDNA sequences (see all 1359):

    BM554962 BU618179 BU172532 AA354980 AW576560 F09122 BP377856 BM453749 
    AV703293 BU781785 BE929419 AA954112 W88998 AW516747 BC042843 CF135725 
    CR609178 BQ956035 BP357075 BQ639108 AI970368 BQ272520 BE175854 BP350624 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CANX (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^
    SP1:                                -     -     -     -                                                                 -                                       
    SP2:                          -     -     -     -     -                 -     -     -     -                             -                                       
    SP3:                                                                                                                                                            
    SP4:                                -     -     -     -     -     -     -     -                                                                                 
    SP5:                                -     -     -                                                                                                               

    ExUns: 17 ^ 18a · 18b ^ 19 ^ 20
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for CANX

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CANX expression in normal human tissues (normalized intensities)      CANX embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTACTAAATG
    CANX Expression
    About this image


    CANX expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    CANX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CANX Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567968
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CANX: 
              Cellular Stress Responses in human mouse rat
              Unfolded Protein Response in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CANX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CANX gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Canx1 , 5 calnexin1, 5 88.31(n)1
    92.2(a)1
      11 (30.46 cM)5
    123301  NM_001110499.11  NP_001103969.11 
     502944675 
    chicken
    (Gallus gallus)
    Aves CANX1 calnexin 79.44(n)
    84.58(a)
      416288  NM_001030620.1  NP_001025791.2 
    lizard
    (Anolis carolinensis)
    Reptilia CANX6
    calnexin
    80(a)
    1 ↔ 1
    2(140338701-140365625)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044970.12   -- 77.51(n)    BC044970.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc27b062 Danio rerio cDNA clone MGC63524 IMAGE3815058, complete cds less 77.37(n)    BC054903.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cnx99A3
    Cnx14D1
    chaperone3
    Calnexin 14D1
    61(a)
    (best of 3)3
    57.23(n)1
    54.72(a)1
      99A73
    326201  NM_132903.21  NP_573131.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cnx-11 , 3 Calnexin3
    cnx-11
    47(a)3
    55.9(n)1
    47.79(a)1
      III(9886353-9888845)3
    1763901  NM_066775.41  NP_499176.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CNE1(YAL058W)4 Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast less   --   1(37464-38972) 851241  NP_009343.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CNX11 CNX1 58.25(n)
    52.83(a)
      836301  NM_125573.3  NP_200987.1 
    rice
    (Oryza sativa)
    Liliopsida Os.110922 Oryza sativa (japonica cultivar-group) cDNA cloneJ023008D14, full insert sequence less 75.81(n)    AK069118.1 


    ENSEMBL Gene Tree for CANX (if available)
    TreeFam Gene Tree for CANX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CANX gene
    CLGN2  CALR32  CALR2  
    1 SIMAP similar gene for CANX using alignment to 15 protein entries:     CALX_HUMAN (see all proteins):
    CLGN

    CANX for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for CANX (see all 686)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1152390701,2
    C,F--179124082(+) GAGACG/TGGTTC 2 -- us2k11Minor allele frequency- T:0.22WA 118
    rs1383941181,2
    C--179124202(+) GTCTAC/TGGGTG 2 -- us2k10--------
    rs1438799741,2
    --179124425(+) TCCCAC/TTGAAT 2 -- us2k10--------
    rs1869914141,2
    --179124629(+) AAGTTA/GGGGCG 2 -- us2k10--------
    rs286561951,2
    C--179124673(+) GAGGCC/AGAGGC 2 -- us2k1 tfbs38Minor allele frequency- A:0.00NA WA CSA 14
    rs1483776241,2
    --179124837(+) TGAGCC/TAAGAT 2 -- us2k10--------
    rs77007751,2
    C,A,H--179124853(+) CACTAC/GACTCC 2 -- us2k17Minor allele frequency- G:0.00NA WA CSA 13
    rs77212561,2
    C,F,H--179124859(+) actccA/Cgcctg 2 -- us2k14Minor allele frequency- C:0.00NS EA 418
    rs1915136421,2
    --179125025(+) TTCTAG/TTGTTT 2 -- us2k10--------
    rs733381281,2
    C,F--179125157(+) ACTGAA/GGATGT 2 -- us2k12Minor allele frequency- G:0.08WA 120

    HapMap Linkage Disequilibrium report for CANX (179105629 - 179158642 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CANX:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5160CNV Insertion18451855
    nsv883270CNV Loss21882294
    nsv830560CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for CANX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 114217    OMIM disorders: --

    Selected diseases for CANX (see all 39):    About MalaCards
    orbital melanoma    nephrogenic diabetes insipidus    albinism    oculocutaneous albinism
    diabetes insipidus    thymoma    long qt syndrome    cystic fibrosis
    hydrocephalus    motor neuron disease    protein s deficiency    severe acute respiratory syndrome
    influenza    measles    colon adenocarcinoma    astrocytoma
    medulloblastoma    esophageal cancer    melanoma    psoriasis

    1 disease from the University of Copenhagen DISEASES database for CANX:
    Cystic fibrosis

    CANX for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CANX gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cystic fibrosis 40 4 7513695 (1), 18716059 (1), 15923638 (1)
    albinism 37.1 1 15677452 (1)
    shock 17.5 9 16404716 (1), 18230692 (1), 20137130 (1), 16061483 (1) (see all 6)
    mastocytoma 15.2 1 10956670 (1)
    influenza 14.4 4 16407314 (1), 9348279 (1), 8534914 (1), 14731400 (1)
    melanoma 8.7 7 14732231 (2), 7531726 (2), 10360639 (1), 8219759 (1)
    necrosis 4.99 1 9135824 (1)
    tumors 3.47 8 10738909 (3), 14732231 (1), 10933198 (1), 17545629 (1) (see all 5)
    metastasis 2.94 2 14685900 (1)
    cancer 1.14 2 10738909 (1), 16098126 (1)

    Genetic Association Database (GAD): CANX

    Export disorders for CANX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CANX gene, integrated from 10 sources (see all 481):
    (articles sorted by number of sources associating them with CANX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human, mouse, and rat calnexin cDNA cloning: identification of potential calcium binding motifs and gene localization to human chromosome 5. (PubMed id 8136357)1, 2, 3, 9 Tjoelker L.W.... Gray P.W. (Biochemistry 1994)
    2. The major histocompatibility complex class I antigen-binding protein p88 is the product of the calnexin gene. (PubMed id 1326756)1, 2, 3, 9 Galvin K.... Ozturk M. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    3. The molecular chaperones HSP28, GRP78, endoplasmin, and calnexin exhibit strikingly different levels in quiescent keratinocytes as compared to their proliferating normal and transformed counterparts: cDNA cloning and expression of calnexin. (PubMed id 8055875)1, 2, 9 Honore B....Celis J.E. (Electrophoresis 1994)
    4. Palmitoylated calnexin is a key component of the ribosome-translocon complex. (PubMed id 22314232)1, 2 Lakkaraju A.K.... van der Goot F.G. (EMBO J. 2012)
    5. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (J. Proteome Res. 2006)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. Mechanisms of pharmacological rescue of trafficking-defective hERG mutant channels in human long QT syndrome. (PubMed id 16361248)1, 2 Gong Q.... Zhou Z. (J. Biol. Chem. 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. (PubMed id 12643545)1, 2 Basrur V.... Appella E. (J. Proteome Res. 2003)
    10. Differential interaction of coagulation factor VIII and factor V with protein chaperones calnexin and calreticulin. (PubMed id 9525969)1, 7 Pipe S.W....Kaufman R.J. (J. Biol. Chem. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 821 HGNC: 1473 AceView: LOC389352 Ensembl:ENSG00000127022 euGenes: HUgn821
    ECgene: CANX Kegg: 821 H-InvDB: CANX

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CANX Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Calnexin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CANX gene:
    Search GeneIP for patents involving CANX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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