V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

CANX Gene

protein-coding GIFtS: 66

GC05P179058

calnexin
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CNX ^¹, ²
FLJ26570 ^²
IP90 ^¹, ², ³
P90 ^¹, ²
calnexin ^²
p90 ^³

Descriptions
Major histocompatibility complex class I antigen-binding protein p88 ^², ³

External Ids
HGNC: 1473¹
Entrez Gene: 821²
UniProtKB: P27824³
Ensembl: ENSG00000127022⁷

Search outside databases for aliases for CANX gene

Previous GC identifers: GC05P179238 GC05P180070 GC05P179190 GC05P179235

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CANX:

This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a

calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with

newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also

play a central role in the quality control of protein folding by retaining incorrectly folded

protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding

the same protein have been described. [provided by RefSeq]

UniProtKB/Swiss-Prot: CALX_HUMAN, P27824

Function: Calcium-binding protein that interacts with newly synthesized glycoproteins in the

endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the

ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus

of the ER by the retention of incorrectly folded proteins

Gene Wiki entry for CANX (Calnexin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CANX gene

Entrez Gene cytogenetic band: 5q35 Ensembl cytogenetic band: 5q35.3 HGNC cytogenetic band: 5q35

CANX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P179058: (about GC identifiers)

Start:	179,058,536 bp from pter
End:	179,091,248 bp from pter
Size:	32,713 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000005.8 NT_023133.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CALX_HUMAN, P27824 (See protein sequence)

Recommended Name: Calnexin precursor

Size: 592 amino acids; 67568 Da

Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001019820.1 NP_001737.1

ENSEMBL proteins:

ENSP00000366152 ENSP00000247461 ENSP00000346370

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Calnexin - ER membrane marker)
	Human Recombinant Proteins from Abnova (CANX)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IDA	14966132
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--
GO:0042470	melanosome	IEA	--

About this table

Antibodies for CANX:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of CANX
	Sigma-Aldrich Antibody Arrays and Antibodies for CANX
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for CANX (Calnexin)
	Antibodies from Abcam (Calnexin - ER membrane marker), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CANX)
	Novus Biologicals Antibodies for CANX

Assays for CANX:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P27824

ProtoNet protein and cluster: P27824

1 Blocks protein family: IPB001580 Calreticulin

UniProtKB/Swiss-Prot: CALX_HUMAN, P27824

Similarity: Belongs to the calreticulin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CANX)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CANX)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001024649

Applied Biosystems Silencer® siRNAs for CANX

Sigma-Aldrich siRNA for CANX

Sigma-Aldrich shRNA for CANX

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CANX
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001024649
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001024649
untagged cDNA clones in CMV expression vector (see all 2): NM_001024649

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001746

UniProtKB/Swiss-Prot: CALX_HUMAN, P27824

Function: Calcium-binding protein that interacts with newly synthesized glycoproteins in the

endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the

ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus

of the ER by the retention of incorrectly folded proteins

Genatlas biochemistry entry for CANX:

calnexin,90kDa,integral membrane,calcium binding protein,chaperone,interacting with an ER-located

peptide transporter for peptide translocation into microsomes

5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Canx):

behavior/neurological

growth/size

lethality-postnatal

nervous system

no phenotypic analysis

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	TAS	8136357
GO:0005529	sugar binding	IEA	--
GO:0051082	unfolded protein binding	NAS	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for CANX (Your Favorite Gene powered by Ingenuity)

Antigen Presentation Pathway
Lipid Antigen Presentation by CD1

GeneDecks CANX for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CANX

5/82 Interacting proteins for CANX (P27824^{1, 2} ENSP00000247461³) via UniProtKB, MINT, and/or STRING (see all 82 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CFTR	P13569², ENSP00000003084³	MINT-1794992 MINT-1794969 MINT-14845 STRING (score=.999)
PSMB5	P28074², ENSP00000355325³	MINT-6176482 STRING (score=.953)
VCP	P55072², ENSP00000351777³	MINT-6176482 STRING (score=.942)
PSMB1	P20618², ENSP00000262193³	MINT-6176482 STRING (score=.928)
PRAF2	O60831², ENSP00000365570³	MINT-58201 STRING (score=.784)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006457	protein folding	IEA	--
GO:0009306	protein secretion	TAS	8055875

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CANX
10/23 Novoseek chemical compound relationships for CANX gene (see all 23 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
dolichyl diphosphate	81.01	1	10794707 (1)
man9(glcnac)2	71.65	1	18524852 (1)
mannose	61.16	9	10801790 (2), 9065464 (1), 10671537 (1), 11278527 (1) (see all 8)
vtcs	60.73	2	10427085 (1), 15213841 (1)
udpglucose	60.36	10	12181335 (2), 16154739 (1), 17643373 (1), 12671684 (1) (see all 5)
tetrasaccharide	39.84	1	12706973 (1)
dithiothreitol	36.03	7	11796709 (1), 7729412 (1), 16752927 (1), 7642652 (1) (see all 5)
mannose 6-phosphate	31.07	1	15757671 (1)
glucose	29.25	39	7499436 (4), 9020131 (4), 12239218 (2), 10504336 (2) (see all 21)
ryanodine	27.31	2	11580896 (1), 12407053 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CANX)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CANX)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001024649

Sigma-Aldrich siRNA for CANX

Sigma-Aldrich shRNA for CANX

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001024649 NM_001746

REFSEQ mRNAs for CANX gene (2 alternative transcripts):

NM_001024649.1 NM_001746.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001024649 NM_001746

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001024649
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001024649
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001024649

Additional cDNA sequence:

AF070646.1 AJ271880.1 AK129990.1 AK130080.1 AK294702.1 AK304420.1 AK312334.1 BC003552.1

BC042843.1 BC050534.1 BX537700.1 CR609178.1 CR613697.1 L10284.1 L18887.1 M94859.1

M98452.1 S67659.1

24/56 DOTS entries (see all 56 ):

DT.91889830 DT.97865395 DT.40116945 DT.450755 DT.100887015 DT.97760178 DT.100032450 DT.75101647

DT.91711926 DT.100887002 DT.99960318 DT.120874219 DT.120874237 DT.91949811 DT.95093053 DT.95093098

DT.120874210 DT.120874223 DT.100035034 DT.100886999 DT.100887008 DT.120874153 DT.92027265 DT.92463793

24/1359 AceView cDNA sequences (see all 1359 ):

BQ015049 BU171327 AA425090 AW612892 AI654260 F04923 BP345481 AA732976

BQ639108 AI560540 AA354980 BM457901 BU172532 F07403 BX476032 AW594012

AL537146 CB137929 M94859 AI803817 AA384195 BP341781 AF070646 AW500108

highest scoring ESTs for CANX:

AW006369 L10284 AA054145 AA070640 AA074678 AA112407 AA114030 AA114031 AA114045 AA134159

Unigene Cluster for CANX:

Calnexin

Hs.699155 [show with all ESTs]

Unigene Representative Sequence: NM_001746

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CANX (see all 8 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7	^	8	^	9a	·	9b	·	9c	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15a	·	15b	^	16	^
SP1:											-		-		-		-																						-
SP2:									-		-		-		-		-						-		-		-		-										-
SP3:
SP4:											-		-		-		-		-		-		-		-
SP5:											-		-		-

ExUns:	17	^	18a	·	18b	^	19	^	20
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for CANX

3 Ensembl transcripts including schematic representations:

ENST00000376953 ENST00000247461 ENST00000354394

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CANX expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CANX

¹ / ² / ³

11 probe-sets matching CANX gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40125_at²^{, 3}	U95-A	1	1.00	1.00	0.78	1.02	L10284	1.00	1.00	1.00	1
57826_at²^{, 3}	U95-C	1	1.00	1.00	0.70	1.11	AW006369	1.00	1.00	1.00	1
53131_at²^{, 3}	U95-C	1	0.94	1.00	0.36	0.88	N25670	0.80	1.00	0.91	1
200068_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	M94859	0.80	1.00	0.91	1
208852_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI761759	0.80	1.00	0.91	1
238034_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI890021	0.60	1.00	0.82	1
208853_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	L18887	0.80	1.00	0.91	1
200068_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208852_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
238034_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208853_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTACTAAATG

SOURCE GeneReport for Unigene cluster: Hs.699155
Expression variation in blood from EXPOLDB for CANX

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CANX gene from 5/23 species (see all 23 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CANX¹	--	calnexin	91.6(n) 95.43(a)	403908 NM_001003232.1 NP_001003232.1
chimpanzee (Pan troglodytes)	CANX¹	--	calnexin	99.32(n) 99.16(a)	462330 XM_001151434.1 XP_001151434.1
rat (Rattus norvegicus)	Canx¹	--	calnexin	90.15(n) 94.4(a)	29144 NM_172008.1 NP_742005.1
mouse (Mus musculus)	Canx^{1, 5}	11 (30.00 cM)⁵	calnexin^{1, 5}	88.98(n)¹ 93.39(a)¹	12330¹ NM_007597.2¹ NP_031623.1¹ AI853036⁵ AI988026⁵ (see all 27)
chicken (Gallus gallus)	CANX¹	--	calnexin	79.77(n) 85.64(a)	416288 NM_001030620.1 NP_001025791.1

About this table Species with no ortholog for CANX

ENSEMBL Gene Tree for CANX

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CANX gene

CLGN² CALR² CALR3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/163 NCBI SNPs in CANX are shown (see all 163 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 42)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs6639^1,2	A,C,F,H,O	179089388(+)	`GACTTG/TAGAAG`	2	--	ut3¹ ese³		6		MN EU EA WA	790
	rs7566^1,2	A,C,F,H	179089055(+)	`AGGAAC/TGCTAG`	2	--	ut3¹ ese³		8		MN EU EA WA NA	964
	rs4701195^1,2	A,C,F	179058004(+)	`GGCGCC/GGGCTC`	2	--	ng5¹		2		MN EA	356
	rs4701196^1,2	A,C,F	179058541(+)	`AGGGCC/AGGGCT`	2	--	ut5¹ ese³		2		MN EA	356
	rs1135927^1,2	A,C	179090454(+)	`ATTTTC/TTTATC`	2	--	ut3¹		1		MN	184
	rs11749335^1,2	C,F	179058696(+)	`GGTCCT/CCGGGA`	2	--	ut5¹ int¹ ese³		2		MN EA	356
--	rs7700775^1,2	A,C	179057459(+)	`cactaC/Gactcc`	2	--	ng5¹		0	--	--	--	--
--	rs17079630^1,2	F	179058284(+)	`TTAAAC/GCAGCC`	2	--	ng5¹		1		EA	200
	rs10387^1,2	C	179089760(+)	`TTCTTT/CAGAGG`	2	--	ut3¹ ese³		1		MN	184
--	rs7721256^1,2	H	179057465(+)	`actccA/Cgcctg`	2	--	ng5¹		4		EU EA WA	418

About this table

HapMap Linkage Disequilibrium images for CANX (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 114217

10/16 Novoseek disease relationships for CANX gene (see all 16 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cystic fibrosis	41.99	4	7513695 (1), 18716059 (1), 15923638 (1)
albinism	39.29	1	15677452 (1)
influenza	18.81	4	16407314 (1), 9348279 (1), 8534914 (1), 14731400 (1)
shock	17.81	8	16404716 (1), 18230692 (1), 16061483 (1), 9688848 (1) (see all 5)
mastocytoma	16.96	1	10956670 (1)
melanoma	11.24	7	14732231 (2), 7531726 (2), 10360639 (1), 8219759 (1)
carcinoma	5.00	1	17622526 (1)
necrosis	3.67	1	9135824 (1)
metastasis	3.42	2	14685900 (1)
tumors	3.02	8	10738909 (3), 14732231 (1), 10933198 (1), 17545629 (1) (see all 5)

About this table

Genetic Association Database: CANX

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/361 PubMed articles for CANX gene (see all 361 ):

Human, mouse, and rat calnexin cDNA cloning: identification of potential calcium binding motifs and gene localization to human chromosome 5. (PubMed id 8136357)^{1, 2, 3, 4} Tjoelker L.W....Gray P.W. (1994)
The major histocompatibility complex class I antigen-binding protein p88 is the product of the calnexin gene. (PubMed id 1326756)^{1, 2, 3, 4} Galvin K.... Ozturk M. (1992)
The molecular chaperones HSP28, GRP78, endoplasmin, and calnexin exhibit strikingly different levels in quiescent keratinocytes as compared to their proliferating normal and transformed counterparts: cDNA cloning and expression of calnexin. (PubMed id 8055875)^{1, 3, 4} Honore B....Celis J.E. (1994)
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)^{3, 4} Chi A....Hunt D.F. (2006)
Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)^{3, 4} Nousiainen M.... Koerner R. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. (PubMed id 12643545)^{3, 4} Basrur V.... Appella E. (2003)
Interaction with newly synthesized and retained proteins in the endoplasmic reticulum suggests a chaperone function for human integral membrane protein IP90 (calnexin). (PubMed id 8486646)^{3, 4} David V.... Brenner M.B. (1993)
Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PubMed id 1286667)^{3, 4} Rasmussen H.H....Vandekerckhove J. (1992)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 821	HGNC: 1473	AceView: LOC389352	Ensembl:ENSG00000127022	euGenes: HUgn821
ECgene: CANX	H-InvDB: CANX

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Wikipedia	http://en.wikipedia.org/wiki/Calnexin

Licensable Technologies for CANX
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CANX:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CANX-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CANX		Antibodies for CANX
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CANX		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CANX)
	Antibodies (CANX)
	Chimera RNAi (CANX)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for CANX (Calnexin)

	Recombinant Proteins (Calnexin - ER membrane marker)
	Antibodies (Calnexin - ER membrane marker)

Search OriGene for CANX

Search Tocris compounds for CANX

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CANX

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CANX Gene at Home site.
Version 2.41.1
server5.xennexinc.com

CANX Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for CANX

Summaries
for CANX

Genomic Location
for CANX

Proteins
for CANX

Protein Domains/
Families
for CANX

Gene Function
for CANX

Pathways & Interactions
for CANX

Drugs & Compounds
for CANX

Transcripts
for CANX

Expression
for CANX

Orthologs
for CANX

Paralogs
for CANX

SNPs/Variants
for CANX

Disorders & Mutations
for CANX

Medical News
for CANX

Publications
for CANX

Search for CANX

Genome Databases showing CANX

Other Databases showing CANX

Specialized Databases showing CANX

Licensable Technologies
for CANX

Services
for CANX

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CANX Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor CANX

Summariesfor CANX

Genomic Locationfor CANX

Proteinsfor CANX

Protein Domains/Familiesfor CANX

Gene Functionfor CANX

Pathways & Interactionsfor CANX

Drugs & Compoundsfor CANX

Transcriptsfor CANX

Expression for CANX

Orthologsfor CANX

Paralogsfor CANX

SNPs/Variantsfor CANX

Disorders & Mutationsfor CANX

Medical Newsfor CANX

Publicationsfor CANX

Search for CANX

Genome Databases showing CANX

Other Databases showing CANX

Specialized Databases showing CANX

Licensable Technologiesfor CANX

Servicesfor CANX

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CANX

Summaries
for CANX

Genomic Location
for CANX

Proteins
for CANX

Protein Domains/
Families
for CANX

Gene Function
for CANX

Pathways & Interactions
for CANX

Drugs & Compounds
for CANX

Transcripts
for CANX

Expression
for CANX

Orthologs
for CANX

Paralogs
for CANX

SNPs/Variants
for CANX

Disorders & Mutations
for CANX

Medical News
for CANX

Publications
for CANX

Licensable Technologies
for CANX

Services
for CANX