Aliases for CANX Gene
External Ids for CANX Gene
Previous GeneCards Identifiers for CANX Gene
This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for CANX Gene
CANX (Calnexin) is a Protein Coding gene. Diseases associated with CANX include cystic fibrosis and granulocytopenia. Among its related pathways are Transport to the Golgi and subsequent modification and Immune System. GO annotations related to this gene include poly(A) RNA binding and carbohydrate binding. An important paralog of this gene is CALR.
UniProtKB/Swiss-Prot for CANX Gene
Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.