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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CANX Gene

protein-coding   GIFtS: 69
GCID: GC05P179105

Calnexin

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
calnexin1 2
Major Histocompatibility Complex Class I Antigen-Binding Protein P881 2 3
IP902 3
CNX2
P902
p903

External Ids:    HGNC: 14731   Entrez Gene: 8212   Ensembl: ENSG000001270227   OMIM: 1142175   UniProtKB: P278243   

Export aliases for CANX gene to outside databases

Previous GC identifers: GC05P179238 GC05P180070 GC05P179190 GC05P179235 GC05P179058 GC05P173852


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CANX Gene:
This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a
calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized
N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality
control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation.
Alternatively spliced transcript variants encoding the same protein have been described. (provided by RefSeq, Jul
2008)

GeneCards Summary for CANX Gene: 
CANX (calnexin) is a protein-coding gene. Diseases associated with CANX include orbital melanoma, and nephrogenic diabetes insipidus, and among its related super-pathways are WNT ligand biogenesis and trafficking and N-glycan trimming in the ER and Calnexin/Calreticulin cycle. GO annotations related to this gene include apolipoprotein binding and calcium ion binding. An important paralog of this gene is CLGN.

UniProtKB/Swiss-Prot: CALX_HUMAN, P27824
Function: Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic
reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein
subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of
incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of
immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may
play a role in receptor-mediated endocytosis at the synapse

Gene Wiki entry for CANX (Calnexin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_023133.13  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CANX gene promoter:
         CREB   AP-1   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCANX promoter sequence
   Search SABiosciences Chromatin IP Primers for CANX

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CANX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35

CANX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CANX gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P179105:  view genomic region     (about GC identifiers)

Start:
179,105,629 bp from pter      End:
179,158,642 bp from pter
Size:
53,014 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CALX_HUMAN, P27824 (See protein sequence)
Recommended Name: Calnexin precursor  
Size: 592 amino acids; 67568 Da
Subunit: Interacts with MAPK3/ERK1. Interacts with KCNH2. Associates with ribosomes. Interacts with SGIP1;
involved in negative regulation of endocytosis (By similarity). The palmitoylated form interacts with the
ribosome-translocon complex component SSR1, promoting efficient folding of glycoproteins
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Melanosome.
Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. The palmitoylated form
preferentially localizes to the perinuclear rough ER
Secondary accessions: B2R5V8 D3DWQ3

Explore the universe of human proteins at neXtProt for CANX: NX_P27824

Explore proteomics data for CANX at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated at Ser-564 by MAPK3/ERK1. phosphorylation by MAPK3/ERK1 increases its association with ribosomes
    (By similarity)
  • UniProtKB: Palmitoylation by DHHC6 leads to the preferential localization to the perinuclear rough ER. It mediates the
    association of calnexin with the ribosome-translocon complex (RTC) which is required for efficient folding of
    glycosylated proteins
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P27824

  • CANX Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CANX Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001019820.1  NP_001737.1  

    ENSEMBL proteins: 
     ENSP00000424341   ENSP00000424745   ENSP00000424063   ENSP00000247461   ENSP00000391646  
     ENSP00000425246   ENSP00000426052   ENSP00000426425   ENSP00000421813   ENSP00000421107  
     ENSP00000426555   ENSP00000427115   ENSP00000424740   ENSP00000421434   ENSP00000424140  
     ENSP00000394817   ENSP00000423588  
    Reactome Protein details: P27824
    Human Recombinant Protein Products for CANX: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for CANX
    OriGene Purified Protein for CANX
    OriGene Protein Over-expression Lysate for CANX
    OriGene MassSpec for CANX 
    OriGene Custom Protein Services for CANX
    GenScript Custom Purified and Recombinant Proteins Services for CANX
    Novus Biologicals CANX Proteins
    Novus Biologicals CANX Lysates
    Sino Biological Recombinant Protein for CANX
    Sino Biological Cell Lysate for CANX 
    ProSpec Recombinant Protein for CANX
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005783endoplasmic reticulum IDA--
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0005789endoplasmic reticulum membrane IDA19723497
    GO:0005840ribosome IEA--

    CANX for ontologies           About GeneDecksing



    CANX Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CANX
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CANX  (calnexin)
    OriGene Antibodies for CANX
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    GenScript Superior Antibodies for CANX
    Novus Biologicals CANX Antibodies
    Abcam antibodies for CANX
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for CANX
    LSBio Antibodies in human, mouse, rat for CANX 

    Assay Products for CANX: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CANX
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR018124 Calret/calnex_CS
     IPR013320 ConA-like_subgrp
     IPR009033 Calreticulin/calnexin_P_dom
     IPR001580 Calret/calnex
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry P27824

    ProtoNet protein and cluster: P27824

    1 Blocks protein domain: IPB001580 Calreticulin

    UniProtKB/Swiss-Prot: CALX_HUMAN, P27824
    Similarity: Belongs to the calreticulin family


    CANX for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CALX_HUMAN, P27824
    Function: Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic
    reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein
    subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of
    incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of
    immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may
    play a role in receptor-mediated endocytosis at the synapse

         Genatlas biochemistry entry for CANX:
    calnexin,90kDa,integral membrane,calcium binding protein,chaperone,interacting with an ER-located peptide
    transporter for peptide translocation into microsomes

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI16361248
    GO:0034185apolipoprotein binding IEA--
    GO:0035255ionotropic glutamate receptor binding IEA--
    GO:0051082unfolded protein binding NAS--
         
    CANX for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CANX:
     Decreased homologous recombina  G0/1 arrest  Increased G1 DNA content  Increased gamma-H2AX phosphory 

         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Canx):
     behavior/neurological  growth/size  immune system  mortality/aging  nervous system 
     no phenotypic analysis 

    CANX for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CANX: Canxtm1.1Den Canxtm1Den Canxtm1.1Osb

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CANX 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CANX

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CANX 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CANX 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CANX
    8/73 QIAGEN miScript miRNA Assays for microRNAs that regulate CANX (see all 73):
    hsa-miR-124* hsa-miR-323-3p hsa-miR-576-3p hsa-miR-200a hsa-miR-128 hsa-miR-138-2* hsa-miR-3909 hsa-miR-130b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CANX
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CANX

    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of CANX

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CANX (see all 16)
    OriGene ORF clones in mouse, rat for CANX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CANX (NM_001024649)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CANX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CANX
    Sirion Biotech Customized lentivirus for stable overexpression of CANX 
                         Customized lentivirus expression plasmids for stable overexpression of CANX 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CANX
    Search LifeMap BioReagents cell lines for CANX
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CANX


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CANX About   (see all 15)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Asparagine N-linked glycosylation
    Asparagine N-linked glycosylation0.77
    Post-translational protein modification0.44
    WNT ligand biogenesis and trafficking0.77
    Metabolism of proteins0.35
    Signaling by Wnt0.62
    2Calnexin/calreticulin cycle
    Calnexin/calreticulin cycle0.85
    N-glycan trimming in the ER and Calnexin/Calreticulin cycle0.85
    3Immune System
    Immune System0.56
    Adaptive Immune System0.56
    4Immune response Antigen presentation by MHC class I
    Immune response Antigen presentation by MHC class I0.92
    5Antigen processing: Ubiquitination & Proteasome degradation
    Class I MHC mediated antigen processing & presentation0.83

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CANX
        Immune response Antigen presentation by MHC class I


    1 Cell Signaling Technology (CST) Pathway for CANX
        Translational Control

    2 GeneGo (Thomson Reuters) Pathways for CANX
        Immune response Antigen presentation by MHC class I
    CFTR folding and maturation (norm and CF)


    5/13        Reactome Pathways for CANX (see all 13)
        Antigen Presentation: Folding, assembly and peptide loading of class I MHC
    Signaling by Wnt
    Asparagine N-linked glycosylation
    Calnexin/calreticulin cycle
    Adaptive Immune System


    5         Kegg Pathways  (Kegg details for CANX):
        Protein processing in endoplasmic reticulum
    Phagosome
    Antigen processing and presentation
    Thyroid hormone synthesis
    HTLV-I infection


    CANX for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CANX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/218 Interacting proteins for CANX (P278241, 2, 3 ENSP000002474614) via UniProtKB, MINT, STRING, and/or I2D (see all 218)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SSR1P433072, 3, ENSP000002447634MINT-8381470 MINT-8381592 MINT-4546746 MINT-8381601 MINT-8381559 MINT-8381581 I2D: score=1 STRING: ENSP00000244763
    OPRD1P411432, 3, ENSP000002349614MINT-7889342 MINT-7889483 MINT-7889460 MINT-7889449 I2D: score=1 STRING: ENSP00000234961
    CALRP277972, 3, ENSP000003208664MINT-8361157 MINT-8361140 I2D: score=1 STRING: ENSP00000320866
    TNFRSF1AP194382, 3, ENSP000001627494MINT-49320 I2D: score=3 STRING: ENSP00000162749
    ABCA3Q997582, 3, ENSP000003017324MINT-7996633 I2D: score=1 STRING: ENSP00000301732
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0006457protein folding TAS--
    GO:0007568aging IEA--
    GO:0009306protein secretion TAS8055875
    GO:0018279protein N-linked glycosylation via asparagine TAS--

    CANX for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CANX for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CANX (CALX)

    1 HMDB Compound for CANX    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 DrugBank Compounds for CANX    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Antihemophilic FactorAHF (see all 3)--targetchaperone9607108 15213841 9525969 17139284 17899080 17016423
    Tenecteplaset- PA (see all 4)191588-94-0target--9359841

    10/36 Novoseek inferred chemical compound relationships for CANX gene (see all 36)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    castanospermine 91.6 35 11984787 (3), 8612572 (2), 14978212 (2), 9642271 (2) (see all 21)
    dolichyl diphosphate 80.5 1 10794707 (1)
    man9(glcnac)2 70.8 1 18524852 (1)
    tunicamycin 70.7 17 16858427 (3), 17203246 (2), 8702523 (1), 9032450 (1) (see all 10)
    polysaccharide 66.9 40 9020131 (3), 18803404 (3), 9348279 (2), 16039588 (2) (see all 28)
    mannose 61.3 9 10801790 (2), 9065464 (1), 10671537 (1), 11278527 (1) (see all 8)
    udpglucose 60.7 11 12181335 (2), 16154739 (1), 17643373 (1), 12671684 (1) (see all 6)
    vtcs 59.6 2 10427085 (1), 15213841 (1)
    miglustat 59.4 2 16546175 (1)
    deoxymannojirimycin 57 1 8639654 (1)

    Search CenterWatch for drugs/clinical trials and news about CANX / CALX

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CANX gene (2 alternative transcripts): 
    NM_001024649.1  NM_001746.3  

    Unigene Cluster for CANX:

    Calnexin
    Hs.567968  [show with all ESTs]
    Unigene Representative Sequence: NM_001746
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000514383 ENST00000502296 ENST00000504734 ENST00000247461(uc003mkk.3 uc011dgq.2)
    ENST00000452673(uc011dgp.2 uc010jlb.1 uc003mkl.3) ENST00000502498
    ENST00000507307 ENST00000504579 ENST00000513246 ENST00000502673 ENST00000506654
    ENST00000514032 ENST00000510810 ENST00000509563 ENST00000503126 ENST00000508787
    ENST00000506298 ENST00000505090
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CANX
    8/73 QIAGEN miScript miRNA Assays for microRNAs that regulate CANX (see all 73):
    hsa-miR-124* hsa-miR-323-3p hsa-miR-576-3p hsa-miR-200a hsa-miR-128 hsa-miR-138-2* hsa-miR-3909 hsa-miR-130b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): CANX (NM_001024649)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CANX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CANX
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                         Customized lentivirus expression plasmids for stable overexpression of CANX 
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    OriGene qSTAR qPCR primer pairs in human, mouse for CANX
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CANX
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CANX
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CANX

    Additional mRNA sequence: 

    AF070646.1 AJ271880.1 AK129990.1 AK130080.1 AK294702.1 AK304420.1 AK312334.1 BC003552.1 
    BC042843.1 BC050534.1 BX537700.1 L10284.1 L18887.1 M94859.1 M98452.1 S67659.1 

    24/55 DOTS entries (see all 55):

    DT.91889830  DT.97865395  DT.40116945  DT.450755  DT.100887015  DT.97760178  DT.100032450  DT.91711926 
    DT.100887002  DT.99960318  DT.120874219  DT.120874237  DT.91949811  DT.95093053  DT.95093098  DT.120874210 
    DT.120874223  DT.100035034  DT.100886999  DT.100887008  DT.120874153  DT.120874188  DT.92027265  DT.92463793 

    24/1359 AceView cDNA sequences (see all 1359):

    BQ956035 BU162040 BP353790 AU138830 BM554962 AI355768 BP377856 AA354980 
    CF135725 BE208285 BE929419 BC042843 M94859 AW576560 AA173980 BE892542 
    BP350624 BU781785 CD238290 BE175854 AI050002 BQ639108 BX476032 BM666405 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CANX (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^
    SP1:                                -     -     -     -                                                                 -                                       
    SP2:                          -     -     -     -     -                 -     -     -     -                             -                                       
    SP3:                                                                                                                                                            
    SP4:                                -     -     -     -     -     -     -     -                                                                                 
    SP5:                                -     -     -                                                                                                               

    ExUns: 17 ^ 18a · 18b ^ 19 ^ 20
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for CANX

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CANX expression in normal human tissues (normalized intensities)      CANX embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTACTAAATG
    CANX Expression
    About this image


    CANX expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Lung (Respiratory System)    fully expand to see all 4 entries
             lung ; pneumocytes   
             trachea   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   

    See CANX Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CANX

    SOURCE GeneReport for Unigene cluster: Hs.567968
        SABiosciences Expression via Pathway-Focused PCR Arrays including CANX: 
              Cellular Stress Responses in human mouse rat
              Unfolded Protein Response in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CANX gene from 10/26 species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Canx1 , 5 calnexin1, 5 88.98(n)1
    93.39(a)1
      11 (30.46 cM)5
    123301  NM_007597.31  NP_031623.11 
     502944675 
    chicken
    (Gallus gallus)
    Aves CANX1 calnexin 79.71(n)
    85.54(a)
      416288  NM_001030620.1  NP_001025791.2 
    lizard
    (Anolis carolinensis)
    Reptilia CANX6
    Uncharacterized protein
    80(a)
    1 ↔ 1
    2(140338701-140365625)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044970.12   -- 77.51(n)    BC044970.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc27b062 Danio rerio cDNA clone MGC63524 IMAGE3815058, complete more 77.37(n)    BC054903.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cnx99A3 chaperone 61(a)
    (best of 3)
      99A7   --
    worm
    (Caenorhabditis elegans)
    Secernentea cnx-11 , 3 Calnexin3
    Protein CNX-11
    47(a)3
    54.54(n)1
    44.99(a)1
      III(9886353-9888845)3
    1763901  NM_066775.31  NP_499176.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CNE1(YAL058W)4
    CNE11
    Calnexin; integral membrane ER chaperone involved in more4
    Cne1p1
    48.46(n)1
    34.39(a)1
      1(37464-38972)4
    8512411, 4  NP_009343.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CNX11 calnexin 1 58.2(n)
    52.4(a)
      836301  NM_125573.3  NP_200987.1 
    rice
    (Oryza sativa)
    Liliopsida Os.110922 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 75.81(n)    AK069118.1 


    ENSEMBL Gene Tree for CANX (if available)
    TreeFam Gene Tree for CANX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CANX gene
    CLGN2  CALR32  CALR2  
    1 SIMAP similar gene for CANX using alignment to 15 protein entries:     CALX_HUMAN (see all proteins):
    CLGN

    CANX for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/686 SNPs in CANX are shown (see all 686)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1152390701,2
    C,F--179124082(+) GAGACG/TGGTTC 2 -- us2k11Minor allele frequency- T:0.22WA 118
    rs1383941181,2
    C--179124202(+) GTCTAC/TGGGTG 2 -- us2k10--------
    rs1438799741,2
    --179124425(+) TCCCAC/TTGAAT 2 -- us2k10--------
    rs1869914141,2
    --179124629(+) AAGTTA/GGGGCG 2 -- us2k10--------
    rs286561951,2
    C--179124673(+) GAGGCC/AGAGGC 2 -- us2k1 tfbs38Minor allele frequency- A:0.00NA WA CSA 14
    rs1483776241,2
    --179124837(+) TGAGCC/TAAGAT 2 -- us2k10--------
    rs77007751,2
    C,A,H--179124853(+) CACTAC/GACTCC 2 -- us2k17Minor allele frequency- G:0.00NA WA CSA 13
    rs77212561,2
    C,F,H--179124859(+) actccA/Cgcctg 2 -- us2k14Minor allele frequency- C:0.00NS EA 418
    rs1915136421,2
    --179125025(+) TTCTAG/TTGTTT 2 -- us2k10--------
    rs733381281,2
    C,F--179125157(+) ACTGAA/GGATGT 2 -- us2k12Minor allele frequency- G:0.08WA 120

    HapMap Linkage Disequilibrium report for CANX (179105629 - 179158642 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CANX:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv5160CNV Insertion18451855
    nsv883270CNV Loss21882294
    nsv830560CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 114217    OMIM disorders: --

    20/34 diseases for CANX (see all 34):    About MalaCards
    orbital melanoma    nephrogenic diabetes insipidus    albinism    oculocutaneous albinism
    diabetes insipidus    thymoma    long qt syndrome    hydrocephalus
    motor neuron disease    cystic fibrosis    protein s deficiency    colon adenocarcinoma
    influenza    measles    astrocytoma    medulloblastoma
    esophageal cancer    melanoma    cervicitis    psoriasis

    1 disease from the University of Copenhagen DISEASES database for CANX:
    Cystic fibrosis

    CANX for disorders           About GeneDecksing

    10/16 Novoseek inferred disease relationships for CANX gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cystic fibrosis 40 4 7513695 (1), 18716059 (1), 15923638 (1)
    albinism 37.1 1 15677452 (1)
    shock 17.5 9 16404716 (1), 18230692 (1), 20137130 (1), 16061483 (1) (see all 6)
    mastocytoma 15.2 1 10956670 (1)
    influenza 14.4 4 16407314 (1), 9348279 (1), 8534914 (1), 14731400 (1)
    melanoma 8.7 7 14732231 (2), 7531726 (2), 10360639 (1), 8219759 (1)
    necrosis 4.99 1 9135824 (1)
    tumors 3.47 8 10738909 (3), 14732231 (1), 10933198 (1), 17545629 (1) (see all 5)
    metastasis 2.94 2 14685900 (1)
    cancer 1.14 2 10738909 (1), 16098126 (1)

    Genetic Association Database (GAD): CANX

    Export disorders for CANX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CANX gene, integrated from 9 sources (see all 476):
    (articles sorted by number of sources associating them with CANX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human, mouse, and rat calnexin cDNA cloning: identification of potential calcium binding motifs and gene localization to human chromosome 5. (PubMed id 8136357)1, 2, 3, 9 Tjoelker L.W.... Gray P.W. (1994)
    2. The major histocompatibility complex class I antigen-binding protein p88 is the product of the calnexin gene. (PubMed id 1326756)1, 2, 3, 9 Galvin K.... Ozturk M. (1992)
    3. The molecular chaperones HSP28, GRP78, endoplasmin, and calnexin exhibit strikingly different levels in quiescent keratinocytes as compared to their proliferating normal and transformed counterparts: cDNA cloning and expression of calnexin. (PubMed id 8055875)1, 2, 9 Honore B....Celis J.E. (1994)
    4. Palmitoylated calnexin is a key component of the ribosome-translocon complex. (PubMed id 22314232)1, 2 Lakkaraju A.K.... van der Goot F.G. (2012)
    5. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. Mechanisms of pharmacological rescue of trafficking-defective hERG mutant channels in human long QT syndrome. (PubMed id 16361248)1, 2 Gong Q....Zhou Z. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. (PubMed id 12643545)1, 2 Basrur V.... Appella E. (2003)
    10. Differential interaction of coagulation factor VIII and factor V with protein chaperones calnexin and calreticulin. (PubMed id 9525969)1, 7 Pipe S.W....Kaufman R.J. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 821 HGNC: 1473 AceView: LOC389352 Ensembl:ENSG00000127022 euGenes: HUgn821
    ECgene: CANX Kegg: 821 H-InvDB: CANX

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CANX Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Calnexin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CANX gene:
    Search GeneIP for patents involving CANX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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