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CAND2 Gene

protein-coding   GIFtS: 52
GCID: GC03P012814

Cullin-Associated And Neddylation-Dissociated 2 (Putative)

  Search for CAND2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cullin-Associated And Neddylation-Dissociated 2 (Putative)1 2     TBP-Interacting Protein 120B2 3
TBP Interacting Protein1 2     TBP-Interacting Protein Of 120 KDa B2 3
Cullin-Associated And Neddylation-Dissociated Protein 22 3     Tp120b2
Epididymis Tissue Protein Li 1692 3     Cullin-Associated NEDD8-Dissociated Protein 22
TIP120B2 3     KIAA06673
P120 CAND22 3     

External Ids:    HGNC: 306891   Entrez Gene: 230662   Ensembl: ENSG000001447127   OMIM: 6104035   UniProtKB: O751553   

Export aliases for CAND2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CAND2 Gene:
CAND2 (cullin-associated and neddylation-dissociated 2 (putative)) is a protein-coding gene. GO annotations related to this gene include TBP-class protein binding. An important paralog of this gene is CAND1.

UniProtKB/Swiss-Prot: CAND2_HUMAN, O75155
Function: Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes
the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the
cellular repertoire of SCF complexes (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the CAND2 gene promoter:
         RFX1   ATF-2   Pax-2   FOXD1   Pax-2a   CREB   deltaCREB   c-Jun   MRF-2   En-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CAND2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CAND2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.2   Ensembl cytogenetic band:  3p25.2   HGNC cytogenetic band: 3p25.2

CAND2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAND2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P012814:  view genomic region     (about GC identifiers)

Start:
12,837,971 bp from pter      End:
12,913,415 bp from pter
Size:
75,445 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CAND2_HUMAN, O75155 (See protein sequence)
Recommended Name: Cullin-associated NEDD8-dissociated protein 2  
Size: 1236 amino acids; 135256 Da
Subunit: Binds TBP, CNOT3 and UBE3C (By similarity)
Sequence caution: Sequence=AAI36593.1; Type=Erroneous initiation;
Secondary accessions: B9EGM9 E9KL24
Alternative splicing: 2 isoforms:  O75155-1   O75155-2   

Explore the universe of human proteins at neXtProt for CAND2: NX_O75155

Explore proteomics data for CAND2 at MOPED

Post-translational modifications: 

  • Ubiquitinated and targeted for proteasomal degradation (By similarity)1
  • Ubiquitination2 at Lys20
  • Modification sites at PhosphoSitePlus

  • See CAND2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001155971.1  NP_036430.1  

    ENSEMBL proteins: 
     ENSP00000295989   ENSP00000390996   ENSP00000387641   ENSP00000403093  

    CAND2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR011989 ARM-like
     IPR013932 TATA-bd_TIP120
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry O75155

    ProtoNet protein and cluster: O75155

    2 Blocks protein domains:
    IPB000357 HEAT repeat
    IPB013932 TATA-binding protein interacting (TIP20)


    UniProtKB/Swiss-Prot: CAND2_HUMAN, O75155
    Similarity: Belongs to the CAND family
    Similarity: Contains 26 HEAT repeats


    Find genes that share domains with CAND2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAND2_HUMAN, O75155
    Function: Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes
    the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the
    cellular repertoire of SCF complexes (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI12207886
    GO:0017025TBP-class protein binding IEA--
         
    Find genes that share ontologies with CAND2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CAND2:
     Increased G1 DNA content  Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cand2):
     homeostasis/metabolism 

    Find genes that share phenotypes with CAND2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CAND2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAND2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAND2

    miRNA
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    miRTarBase miRNAs that target CAND2:
    hsa-let-7a-5p (MIRT052532)

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    6 qRT-PCR Assays for microRNAs that regulate CAND2:
    hsa-miR-4324 hsa-miR-544b hsa-miR-124 hsa-miR-506 hsa-miR-490-3p hsa-miR-4308
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CAND2_HUMAN, O75155: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA12692129
    GO:0005634nucleus IEA--

    Find genes that share ontologies with CAND2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CAND2
    Interactions:

        Search GeneGlobe Interaction Network for CAND2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for CAND2 (O751553 ENSP000002959894) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CNOT3O751753, ENSP000002212324I2D: score=2 STRING: ENSP00000221232
    CUL1Q136163, ENSP000003268044I2D: score=2 STRING: ENSP00000326804
    TBPP202263, ENSP000002303544I2D: score=1 STRING: ENSP00000230354
    UBE3CQ153863, ENSP000003091984I2D: score=2 STRING: ENSP00000309198
    TLN1Q9Y4903I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0045893positive regulation of transcription, DNA-templated ISS--

    Find genes that share ontologies with CAND2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CAND2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CAND2 gene (2 alternative transcripts): 
    NM_001162499.1  NM_012298.2  

    Unigene Cluster for CAND2:

    Cullin-associated and neddylation-dissociated 2 (putative)
    Hs.343664  [show with all ESTs]
    Unigene Representative Sequence: NM_001162499
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295989(uc003bxj.2) ENST00000446928 ENST00000456430(uc003bxk.2)
    ENST00000466558 ENST00000454887
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate CAND2:
    hsa-miR-4324 hsa-miR-544b hsa-miR-124 hsa-miR-506 hsa-miR-490-3p hsa-miR-4308
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CAND2
      QuantiTect SYBR Green Assays in human, mouse, rat CAND2
      QuantiFast Probe-based Assays in human, mouse, rat CAND2

    Additional mRNA sequence: 

    AB014567.1 BC136592.1 BX648800.1 GU727621.1 

    9 DOTS entries:

    DT.100052296  DT.40259348  DT.99945073  DT.75172612  DT.70102741  DT.75197842  DT.120880916  DT.120880991 
    DT.99975813 

    Selected AceView cDNA sequences (see all 62):

    AL079841 BE857394 AI914159 CR613433 AB014567 AI698215 BG696221 BQ188038 
    AL045550 F09289 AI086921 AI699404 AW299450 CD106558 BU736736 BX453561 
    AI027494 AI039805 AA971779 BE783517 AI052287 BX648800 W70084 BM704756 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CAND2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15
    SP1:                    -     -     -                                                     -                           
    SP2:                                                                                                                  
    SP3:                                -                                                                                 
    SP4:                    -     -                                                                                       


    ECgene alternative splicing isoforms for CAND2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CAND2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CAND2 Expression
    About this image


    CAND2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Heart (Cardiovascular System)
    CAND2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CAND2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.343664

    UniProtKB/Swiss-Prot: CAND2_HUMAN, O75155
    Tissue specificity: Expressed in epididymis (at protein level)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAND2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CAND2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cand21 , 5 cullin-associated and neddylation-dissociated 2 (putative)1, 5 85.86(n)1
    90.69(a)1
      6 (53.71 cM)5
    670881  NM_025958.21  NP_080234.21 
     1157745385 
    chicken
    (Gallus gallus)
    Aves CAND26
    cullin-associated and neddylation-dissociated 2 (p...
    68(a)
    1 ↔ 1
    12(19444973-19459421)
    lizard
    (Anolis carolinensis)
    Reptilia CAND26
    cullin-associated and neddylation-dissociated 2 (p...
    64(a)
    1 ↔ 1
    GL343273.1(809940-839561)
    zebrafish
    (Danio rerio)
    Actinopterygii cand26
    cullin-associated and neddylation-dissociated 2 (p...
    59(a)
    1 ↔ 1
    22(33734811-33748937) ENSDARG00000005749
    fruit fly
    (Drosophila melanogaster)
    Insecta Cand16
    Cullin-associated and neddylation-dissociated 1
    52(a)
    1 → many
    2L(10358134-10362707)
    worm
    (Caenorhabditis elegans)
    Secernentea cand-16
    Protein CAND-1 (cand-1) mRNA, complete cds
    33(a)
    1 → many
    V(16802874-16814563) WBGene00013606


    ENSEMBL Gene Tree for CAND2 (if available)
    TreeFam Gene Tree for CAND2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CAND2 gene
    CAND12  
    1 SIMAP similar gene for CAND2 using alignment to 3 protein entries:     CAND2_HUMAN (see all proteins):
    CAND1

    Find genes that share paralogs with CAND2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CAND2 (see all 1098)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1117875741,2
    C,F--12836511(+) CTGCTC/GCCTCT 2 -- us2k13Minor allele frequency- G:0.03CSA WA NA 239
    rs1819113011,2
    --12836520(+) CTGTCA/TGGGAA 2 -- us2k10--------
    rs1854606451,2
    --12836736(+) AGTCCC/TCAGGG 2 -- us2k10--------
    rs1898730781,2
    --12836743(+) AGGGGA/GCAGGG 2 -- us2k10--------
    rs40349421,2
    C,F,A,H--12836792(-) GATCTG/ATACAA 2 -- us2k124Minor allele frequency- A:0.46NS EA NA WA CSA 2353
    rs738135511,2
    C,F--12836802(+) CTGCAC/TTGTCC 2 -- us2k16Minor allele frequency- T:0.07WA CSA NA EA 364
    rs1806802301,2
    --12836991(+) CAGTGG/TTCTAT 2 -- us2k10--------
    rs30433061,2
    C--12837066(-) AAAAA-/A/AA  
            
    TCTTT
    2 -- us2k11NA 2
    rs3701630101,2
    C--12837066(+) TAAAG-/TTTTTTT 2 -- us2k10--------
    rs1866513081,2
    --12837100(+) GCTCTA/GTCGCC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CAND2 (12837971 - 12913415 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CAND2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv850e199CNV Deletion23128226
    dgv810e201CNV Deletion23290073
    nsv460435CNV Loss19166990
    esv2751977CNV Gain17911159
    nsv7351OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CAND2
    DNA2.0 Custom Variant and Variant Library Synthesis for CAND2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610403    OMIM disorders: --


    Find genes that share disorders with CAND2           About GenesLikeMe

    Genetic Association Database (GAD): CAND2
    Human Genome Epidemiology (HuGE) Navigator: CAND2 (1 document)

    Export disorders for CAND2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CAND2 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with CAND2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (DNA Res. 1998)
    2. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PubMed id 20736409)1, 2 Li J.... Liu Y. (Mol. Cell. Proteomics 2010)
    3. Evaluation of CAND2 and WNT7a as candidate genes for congenital idiopathic clubfoot. (PubMed id 19159115)1, 4 Shyy W....Morcuende J.A. (Clin. Orthop. Relat. Res. 2009)
    4. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (Nature 2006)
    5. TIP120B: a novel TIP120-family protein that is expressed specifically in muscle tissues. (PubMed id 10441524)1, 3 Aoki T....Tamura T.A. (Biochem. Biophys. Res. Commun. 1999)
    6. TBP-interacting protein 120B, which is induced in relation to myogenesis, binds to NOT3. (PubMed id 12207886)1, 9 Aoki T.... Tamura T.-A. (Biochem. Biophys. Res. Commun. 2002)
    7. Proteolytic targeting of transcriptional regulator TIP120B by a HECT domain E3 ligase. (PubMed id 12692129)1, 9 You J.... Pickart C.M. (J. Biol. Chem. 2003)
    8. The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity. (PubMed id 23864651)1 Huang X....Wheeler M.B. (Mol. Endocrinol. 2013)
    9. Regulation of Cullin-RING ubiquitin ligase 1 by Spliceosome-associated protein 130 (SAP130). (PubMed id 23951410)1 Cordero-Espinoza L. and Hagen T. (Biol Open 2013)
    10. Characterization of carbonic anhydrase IX interactome reveals proteins assisting its nuclear localization in hypoxic cells. (PubMed id 23181366)1 Buanne P....Zambrano N. (J. Proteome Res. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23066 HGNC: 30689 AceView: TIP120B Ensembl:ENSG00000144712 euGenes: HUgn23066
    ECgene: CAND2 H-InvDB: CAND2

    (According to HUGE)
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    HUGE: KIAA0667

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CAND2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CAND2 gene:
    Search GeneIP for patents involving CAND2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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