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Aliases for CAND2 Gene

Aliases for CAND2 Gene

  • Cullin Associated And Neddylation Dissociated 2 (Putative) 2 3 5
  • Cullin-Associated And Neddylation-Dissociated Protein 2 3 4
  • TBP-Interacting Protein Of 120 KDa B 3 4
  • Epididymis Tissue Protein Li 169 3 4
  • TBP-Interacting Protein 120B 3 4
  • TBP Interacting Protein 2 3
  • P120 CAND2 3 4
  • TIP120B 3 4
  • Cullin-Associated And Neddylation-Dissociated 2 (Putative) 2
  • Cullin-Associated NEDD8-Dissociated Protein 2 3
  • KIAA0667 4
  • Tp120b 3

External Ids for CAND2 Gene

Summaries for CAND2 Gene

GeneCards Summary for CAND2 Gene

CAND2 (Cullin Associated And Neddylation Dissociated 2 (Putative)) is a Protein Coding gene. GO annotations related to this gene include binding and TBP-class protein binding. An important paralog of this gene is CAND1.

UniProtKB/Swiss-Prot for CAND2 Gene

  • Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAND2 Gene

Genomics for CAND2 Gene

Regulatory Elements for CAND2 Gene

Enhancers for CAND2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CAND2 on UCSC Golden Path with GeneCards custom track

Promoters for CAND2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CAND2 Gene

Chromosome:
3
Start:
12,796,472 bp from pter
End:
12,871,916 bp from pter
Size:
75,445 bases
Orientation:
Plus strand

Genomic View for CAND2 Gene

Genes around CAND2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAND2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAND2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAND2 Gene

Proteins for CAND2 Gene

  • Protein details for CAND2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75155-CAND2_HUMAN
    Recommended name:
    Cullin-associated NEDD8-dissociated protein 2
    Protein Accession:
    O75155
    Secondary Accessions:
    • B9EGM9
    • E9KL24

    Protein attributes for CAND2 Gene

    Size:
    1236 amino acids
    Molecular mass:
    135256 Da
    Quaternary structure:
    • Binds TBP, CNOT3 and UBE3C.
    SequenceCaution:
    • Sequence=AAI36593.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CAND2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAND2 Gene

Post-translational modifications for CAND2 Gene

Other Protein References for CAND2 Gene

No data available for DME Specific Peptides for CAND2 Gene

Domains & Families for CAND2 Gene

Protein Domains for CAND2 Gene

Suggested Antigen Peptide Sequences for CAND2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75155

UniProtKB/Swiss-Prot:

CAND2_HUMAN :
  • Belongs to the CAND family.
  • Contains 26 HEAT repeats.
Family:
  • Belongs to the CAND family.
Similarity:
  • Contains 26 HEAT repeats.
genes like me logo Genes that share domains with CAND2: view

No data available for Gene Families for CAND2 Gene

Function for CAND2 Gene

Molecular function for CAND2 Gene

UniProtKB/Swiss-Prot Function:
Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes.

Gene Ontology (GO) - Molecular Function for CAND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12207886
GO:0017025 TBP-class protein binding IEA --
genes like me logo Genes that share ontologies with CAND2: view
genes like me logo Genes that share phenotypes with CAND2: view

Animal Models for CAND2 Gene

MGI Knock Outs for CAND2:

Animal Model Products

CRISPR Products

miRNA for CAND2 Gene

miRTarBase miRNAs that target CAND2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAND2 Gene

Localization for CAND2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAND2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAND2 Gene COMPARTMENTS Subcellular localization image for CAND2 gene
Compartment Confidence
nucleus 4
cytosol 3
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CAND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 12692129
GO:0005634 nucleus IEA,IBA --
genes like me logo Genes that share ontologies with CAND2: view

Pathways & Interactions for CAND2 Gene

SuperPathways for CAND2 Gene

No Data Available

SIGNOR curated interactions for CAND2 Gene

Other effect:

Gene Ontology (GO) - Biological Process for CAND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0010265 SCF complex assembly IBA --
GO:0016567 protein ubiquitination IBA --
GO:0045893 positive regulation of transcription, DNA-templated ISS --
genes like me logo Genes that share ontologies with CAND2: view

No data available for Pathways by source for CAND2 Gene

Drugs & Compounds for CAND2 Gene

No Compound Related Data Available

Transcripts for CAND2 Gene

Unigene Clusters for CAND2 Gene

Cullin-associated and neddylation-dissociated 2 (putative):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAND2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15
SP1: - - - -
SP2:
SP3: -
SP4: - -

Relevant External Links for CAND2 Gene

GeneLoc Exon Structure for
CAND2
ECgene alternative splicing isoforms for
CAND2

Expression for CAND2 Gene

mRNA expression in normal human tissues for CAND2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAND2 Gene

This gene is overexpressed in Muscle - Skeletal (x17.7).

Protein differential expression in normal tissues from HIPED for CAND2 Gene

This gene is overexpressed in Fetal ovary (9.0), Testis (8.6), and Fetal testis (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CAND2 Gene



Protein tissue co-expression partners for CAND2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CAND2 Gene:

CAND2

SOURCE GeneReport for Unigene cluster for CAND2 Gene:

Hs.343664

mRNA Expression by UniProt/SwissProt for CAND2 Gene:

O75155-CAND2_HUMAN
Tissue specificity: Expressed in epididymis (at protein level).
genes like me logo Genes that share expression patterns with CAND2: view

Primer Products

Orthologs for CAND2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CAND2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CAND2 34
  • 87.46 (n)
  • 91.83 (a)
CAND2 35
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAND2 34
  • 89.97 (n)
  • 95.39 (a)
CAND2 35
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cand2 34
  • 85.86 (n)
  • 90.69 (a)
Cand2 16
Cand2 35
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CAND2 34
  • 99.35 (n)
  • 99.27 (a)
CAND2 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cand2 34
  • 85.67 (n)
  • 91.01 (a)
oppossum
(Monodelphis domestica)
Mammalia CAND2 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAND2 35
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves CAND2 35
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAND2 35
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cand2 35
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cand1 35
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cand-1 35
  • 33 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU08875 34
  • 46.49 (n)
  • 33.8 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 45 (a)
OneToMany
Species where no ortholog for CAND2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CAND2 Gene

ENSEMBL:
Gene Tree for CAND2 (if available)
TreeFam:
Gene Tree for CAND2 (if available)

Paralogs for CAND2 Gene

Paralogs for CAND2 Gene

(1) SIMAP similar genes for CAND2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CAND2: view

Variants for CAND2 Gene

Sequence variations from dbSNP and Humsavar for CAND2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2305398 - 12,815,357(-) GGGGC(C/T)GTGTT reference, missense
rs2305397 - 12,815,994(-) GCACA(A/G)GCATA reference, missense
rs3732675 - 12,816,529(+) CTGAC(C/G/T)CTTTC reference, missense
rs9838943 - 12,816,896(+) ACTGC(A/G)CATTC reference, missense
rs17037287 - 12,817,467(+) TTCTT(G/T)TCGCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CAND2 Gene

Variant ID Type Subtype PubMed ID
dgv763e201 CNV deletion 23290073
dgv850e199 CNV deletion 23128226
esv2751977 CNV gain 17911159
esv3893663 CNV gain 25118596
nsv1112379 CNV deletion 24896259
nsv1127940 CNV deletion 24896259
nsv1147269 CNV deletion 26484159
nsv460435 CNV loss 19166990
nsv589714 CNV loss 21841781
nsv589715 CNV loss 21841781
nsv589716 CNV loss 21841781
nsv7351 OTHER inversion 18451855
nsv965144 CNV duplication 23825009

Variation tolerance for CAND2 Gene

Residual Variation Intolerance Score: 93.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.43; 97.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAND2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAND2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAND2 Gene

Disorders for CAND2 Gene

Relevant External Links for CAND2

Genetic Association Database (GAD)
CAND2
Human Genome Epidemiology (HuGE) Navigator
CAND2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAND2

No disorders were found for CAND2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAND2 Gene

Publications for CAND2 Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4 65
  2. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PMID: 20736409) Li J. … Liu Y. (Mol. Cell. Proteomics 2010) 3 4 65
  3. Evaluation of CAND2 and WNT7a as candidate genes for congenital idiopathic clubfoot. (PMID: 19159115) Shyy W. … Morcuende J.A. (Clin. Orthop. Relat. Res. 2009) 3 46 65
  4. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 3 4 65
  5. Proteolytic targeting of transcriptional regulator TIP120B by a HECT domain E3 ligase. (PMID: 12692129) You J. … Pickart C.M. (J. Biol. Chem. 2003) 3 22 65

Products for CAND2 Gene

Sources for CAND2 Gene

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