Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CAND2 Gene

Aliases for CAND2 Gene

  • Cullin-Associated And Neddylation-Dissociated 2 (Putative) 2 3
  • Cullin-Associated And Neddylation-Dissociated Protein 2 3 4
  • TBP-Interacting Protein Of 120 KDa B 3 4
  • Epididymis Tissue Protein Li 169 3 4
  • TBP-Interacting Protein 120B 3 4
  • TBP Interacting Protein 2 3
  • P120 CAND2 3 4
  • TIP120B 3 4
  • Cullin-Associated NEDD8-Dissociated Protein 2 3
  • KIAA0667 4
  • Tp120b 3

External Ids for CAND2 Gene

Summaries for CAND2 Gene

GeneCards Summary for CAND2 Gene

CAND2 (Cullin-Associated And Neddylation-Dissociated 2 (Putative)) is a Protein Coding gene. GO annotations related to this gene include TBP-class protein binding. An important paralog of this gene is CAND1.

UniProtKB/Swiss-Prot for CAND2 Gene

  • Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAND2 Gene

Genomics for CAND2 Gene

Genomic Location for CAND2 Gene

Start:
12,796,472 bp from pter
End:
12,871,916 bp from pter
Size:
75,445 bases
Orientation:
Plus strand

Genomic View for CAND2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAND2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAND2 Gene

Regulatory Elements for CAND2 Gene

Proteins for CAND2 Gene

  • Protein details for CAND2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75155-CAND2_HUMAN
    Recommended name:
    Cullin-associated NEDD8-dissociated protein 2
    Protein Accession:
    O75155
    Secondary Accessions:
    • B9EGM9
    • E9KL24

    Protein attributes for CAND2 Gene

    Size:
    1236 amino acids
    Molecular mass:
    135256 Da
    Quaternary structure:
    • Binds TBP, CNOT3 and UBE3C.
    SequenceCaution:
    • Sequence=AAI36593.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CAND2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAND2 Gene

Proteomics data for CAND2 Gene at MOPED

Post-translational modifications for CAND2 Gene

Other Protein References for CAND2 Gene

No data available for DME Specific Peptides for CAND2 Gene

Domains for CAND2 Gene

Protein Domains for CAND2 Gene

UniProtKB/Swiss-Prot:

CAND2_HUMAN
Family:
  • Belongs to the CAND family.:
    • O75155
Similarity:
  • Contains 26 HEAT repeats.:
    • O75155
genes like me logo Genes that share domains with CAND2: view

No data available for Gene Families for CAND2 Gene

Function for CAND2 Gene

Molecular function for CAND2 Gene

UniProtKB/Swiss-Prot Function: Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes.

Gene Ontology (GO) - Molecular Function for CAND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 12207886
GO:0017025 TBP-class protein binding IEA --
genes like me logo Genes that share ontologies with CAND2: view

Phenotypes for CAND2 Gene

MGI mutant phenotypes for CAND2:
inferred from 1 alleles
GenomeRNAi human phenotypes for CAND2:
genes like me logo Genes that share phenotypes with CAND2: view

miRNA for CAND2 Gene

miRTarBase miRNAs that target CAND2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CAND2 Gene

Localization for CAND2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAND2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAND2 Gene COMPARTMENTS Subcellular localization image for CAND2 gene
Compartment Confidence
cytosol 2
nucleus 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CAND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 12692129
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with CAND2: view

Pathways for CAND2 Gene

SuperPathways for CAND2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CAND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0010265 SCF complex assembly IBA --
GO:0016567 protein ubiquitination IBA --
GO:0045893 positive regulation of transcription, DNA-templated ISS --
genes like me logo Genes that share ontologies with CAND2: view

No data available for Pathways by source for CAND2 Gene

Transcripts for CAND2 Gene

Unigene Clusters for CAND2 Gene

Cullin-associated and neddylation-dissociated 2 (putative):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAND2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15
SP1: - - - -
SP2:
SP3: -
SP4: - -

Relevant External Links for CAND2 Gene

GeneLoc Exon Structure for
CAND2
ECgene alternative splicing isoforms for
CAND2

Expression for CAND2 Gene

mRNA expression in normal human tissues for CAND2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAND2 Gene

This gene is overexpressed in Muscle - Skeletal (17.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAND2 Gene

SOURCE GeneReport for Unigene cluster for CAND2 Gene Hs.343664

mRNA Expression by UniProt/SwissProt for CAND2 Gene

O75155-CAND2_HUMAN
Tissue specificity: Expressed in epididymis (at protein level).
genes like me logo Genes that share expressions with CAND2: view

Orthologs for CAND2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CAND2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAND2 36
  • 99.35 (n)
  • 99.27 (a)
CAND2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CAND2 36
  • 87.46 (n)
  • 91.83 (a)
CAND2 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAND2 36
  • 89.97 (n)
  • 95.39 (a)
CAND2 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cand2 36
  • 85.86 (n)
  • 90.69 (a)
Cand2 16
Cand2 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CAND2 37
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAND2 37
  • 47 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cand2 36
  • 85.67 (n)
  • 91.01 (a)
chicken
(Gallus gallus)
Aves CAND2 37
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAND2 37
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cand2 37
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cand1 37
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cand-1 37
  • 33 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU08875 36
  • 46.49 (n)
  • 33.8 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 45 (a)
OneToMany
Species with no ortholog for CAND2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CAND2 Gene

ENSEMBL:
Gene Tree for CAND2 (if available)
TreeFam:
Gene Tree for CAND2 (if available)

Paralogs for CAND2 Gene

Paralogs for CAND2 Gene

Selected SIMAP similar genes for CAND2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CAND2: view

Variants for CAND2 Gene

Sequence variations from dbSNP and Humsavar for CAND2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs731646 -- 12,816,324(-) AACAC(A/G)GCCCT intron-variant
rs906671 -- 12,819,489(+) TACTC(A/G)GAAAG intron-variant
rs1079361 -- 12,834,381(+) CTCTG(C/G)TTTCT utr-variant-3-prime
rs1508757 -- 12,814,194(-) GGACA(A/G)CCACA intron-variant
rs1876617 -- 12,830,367(+) TCCAG(A/G)CGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAND2 Gene

Variant ID Type Subtype PubMed ID
dgv810e201 CNV Deletion 23290073
dgv850e199 CNV Deletion 23128226
nsv7351 OTHER Inversion 18451855
esv2751977 CNV Gain 17911159
nsv460435 CNV Loss 19166990

Relevant External Links for CAND2 Gene

HapMap Linkage Disequilibrium report
CAND2

Disorders for CAND2 Gene

Relevant External Links for CAND2

Genetic Association Database (GAD)
CAND2
Human Genome Epidemiology (HuGE) Navigator
CAND2
genes like me logo Genes that share disorders with CAND2: view

No data available for UniProtKB/Swiss-Prot for CAND2 Gene

Publications for CAND2 Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4
  2. TIP120B: a novel TIP120-family protein that is expressed specifically in muscle tissues. (PMID: 10441524) Aoki T. … Tamura T.A. (Biochem. Biophys. Res. Commun. 1999) 2 3
  3. TBP-interacting protein 120B, which is induced in relation to myogenesis, binds to NOT3. (PMID: 12207886) Aoki T. … Tamura T.-A. (Biochem. Biophys. Res. Commun. 2002) 3 23
  4. Proteolytic targeting of transcriptional regulator TIP120B by a HECT domain E3 ligase. (PMID: 12692129) You J. … Pickart C.M. (J. Biol. Chem. 2003) 3 23
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 3 4

Products for CAND2 Gene

Sources for CAND2 Gene

Back to Top

Content