CAND2 Gene
protein-coding GIFtS : 49 GCID: GC03 P012814
cullin-associated and neddylation-dissociated 2 (putative)
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Aliasesfor CAND2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Cullin-Associated And Neddylation-Dissociated 2 (Putative) 1 2 P120 CAND22 3 TIP120B1 2 3 TBP-Interacting Protein 120B2 3 Tp120b1 2 TBP-Interacting Protein Of 120 KDa B2 3 KIAA06671 3 Cullin-Associated NEDD8-Dissociated Protein 22 Cullin-Associated And Neddylation-Dissociated Protein 22 3 TBP Interacting Protein2 Epididymis Tissue Protein Li 1692 3
Export aliases for CAND2 gene to outside databases
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Summariesfor CAND2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: CAND2_HUMAN, O75155 Function : May play a role in the assembly of ubiquitin ligase complexes and modulate the ubiquitination of targetproteins. May be a transcription regulator (Potential)
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Genomic Viewsfor CAND2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000003.11 NC_018914.1 NT_022517.18 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CAND2 gene promoter:RFX1 ATF-2 Pax-2 FOXD1 Pax-2a CREB deltaCREB c-Jun MRF-2 En-1 Other transcription factors Search SABiosciences Chromatin IP Primers for CAND2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAND2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 3p25.2 Ensembl cytogenetic band: 3p25.2 HGNC cytogenetic band: 3p25.2 CAND2 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03P012814: view genomic region
(about GC identifiers )
Start: 12,837,971 bp from pter End:
12,913,415 bp from pter
Size: 75,445 bases Orientation:
plus strand
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Proteinsfor CAND2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CAND2_HUMAN, O75155 See
protein sequence )Recommended Name: Size : 1236 amino acids; 135256 DaSubunit : Binds TBP, CNOT3 and UBE3C (By similarity)Subcellular location : Nucleus (By similarity)Sequence caution : Sequence=AAI36593.1; Type=Erroneous initiation;Secondary accessions : B9EGM9 E9KL24Alternative splicing : 2 isoforms : O75155-1 O75155-2 Explore the universe of human proteins at neXtProt for CAND2: NX_O75155 Post-translational modifications:
Ubiquitinated and targeted for proteasomal degradation (By similarity)1 View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_O75155 CAND2 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (2 alternative transcripts): NP_001155971.1 NP_036430.1 ENSEMBL proteins: ENSP00000295989 ENSP00000390996 ENSP00000387641 ENSP00000403093 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing CAND2 Antibody Products: Assay Products for CAND2:
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Protein
Domains /for CAND2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry O75155 ProtoNet protein and cluster: O75155
2 Blocks protein families : IPB000357 IPB013932 UniProtKB/Swiss-Prot: CAND2_HUMAN, O75155 Similarity : Belongs to the CAND familySimilarity : Contains 26 HEAT repeats
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Functionfor CAND2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: CAND2_HUMAN, O75155 Function : May play a role in the assembly of ubiquitin ligase complexes and modulate the ubiquitination of targetproteins. May be a transcription regulator (Potential)
Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 4 )human mouse rat see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): CAND2 (NM_012298 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CAND2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CAND2
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAND2
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
About GeneDecksing 2 GenomeRNAi human phenotypes for CAND2 :Animal Models: 1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cand2) :About GeneDecksing
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Pathways & Interactionsfor CAND2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CAND2 STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)5/9 Interacting proteins for CAND2 (O75155 3 ENSP00000295989 4 via UniProtKB, MINT, STRING , and/or I2D (see all 9 )About this table Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006351 transcription, DNA-dependent
IEA -- GO:0045893 positive regulation of transcription, DNA-dependent
ISS --
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Drugs & Compoundsfor CAND2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for CAND2 CAND2
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Transcriptsfor CAND2 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CAND2 gene (2 alternative transcripts): NM_001162499.1 NM_012298.2 Unigene Cluster for CAND2:
Cullin-associated and neddylation-dissociated 2 (putative) Hs.343664 [show with all ESTs ] Unigene Representative Sequence: NM_001162499 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000295989 (uc003bxj.2 ) ENST00000446928 ENST00000456430 (uc003bxk.2 )ENST00000466558 ENST00000454887 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 4 )human mouse rat see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): CAND2 (NM_012298 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CAND2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CAND2
Additional cDNA sequence: AB014567.1 BC136592.1 BX648800.1 GU727621.1
9 DOTS entries : DT.100052296 DT.40259348
DT.99945073 DT.75172612 DT.70102741 DT.75197842 DT.120880916 DT.120880991 DT.99975813 24/62 AceView cDNA sequences (see all 62 ):
AI086921 AI698215 AL079841 BE857394 F09289 BQ188038 CR613433 AI699404 AB014567 BG696221 AI914159 AL045550 BQ931556 AI052287 BX453561 AI382446 BE783517 AI027494 AI039805 F11635 CD106558 AA971779 BM985429 BU736736 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for CAND2 About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 SP1 : - - - - SP2 : SP3 : - SP4 : - -
ECgene alternative splicing isoforms for CAND2
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Expression for CAND2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CAND2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image CAND2 expression in embryonic tissues and stem cells About this table See CAND2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CAND2 SOURCE GeneReport for Unigene cluster: Hs.343664 UniProtKB/Swiss-Prot: CAND2_HUMAN, O75155 Tissue specificity : Expressed in epididymis (at protein level)SABiosciences Custom PCR Arrays for CAND2 Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAND2
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Orthologsfor CAND2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for CAND2 gene from 7/25 species (see all 25 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves CAND26
Uncharacterized protein
67(a)
1 ↔ 1
12(20105805-20120674)
lizard Reptilia CAND26
--
65(a)
1 ↔ 1
GL343273.1(809940-839459)
zebrafish Actinopterygii cand26
cullin-associated and neddylation-dissociated 2 (p... 59(a)
1 ↔ 1
22(33734811-33748937)
fruit fly Insecta Cand16
Cullin-associated and neddylation-dissociated 1
51(a)
1 → many
2L(10358134-10362707)
worm Secernentea cand-16
CAND1 (Cullin-Associated NEDD8-Dissociated protein... 33(a)
1 → many
V(16802852-16814541)
thale cress eudicotyledons HVE6
cullin-associated NEDD8-dissociated protein 1
38(a)
1 → many
2(689788-697596)
rice Liliopsida ----
HEAT repeat family protein, putative, expressed
39(a) 28(a)
many ↔ manymany ↔ many
2(3659090-3669320) 2(3778034-3791873)
ENSEMBL Gene Tree for CAND2 (if available)TreeFam Gene Tree for CAND2 (if available)
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Paralogsfor CAND2 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for CAND2 gene CAND1 2 1 SIMAP similar gene for CAND2 using alignment to 3 protein entries: CAND2_HUMAN (see all proteins ):CAND1 About GeneDecksing
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Genomic Variantsfor CAND2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 3 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for CAND2 (12837971 - 12913415 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for CAND2 1 CNV 8414 1 Inversion 37239
SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor CAND2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 610403
OMIM disorders : --3 : About MalaCards clubfoot epididymitis pneumonia Human Genome Epidemiology (HuGE) Navigator: CAND2 (1 document)Export disorders for CAND2 gene to outside databases
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Publicationsfor CAND2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CAND2 gene, integrated from 9 sources (see all 17 ):(articles sorted by number of sources associating them with CAND2) Utopia : connect your pdf to the dynamic
Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811) 1 , 2 , 3(1998) Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PubMed id 20736409) 1 , 2 (2010) The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997) 1 , 2 (2006) TIP120B: a novel TIP120-family protein that is expres sed specifically in muscle tissues. (PubMed id 10441524) 1 , 3(1999) TBP-interacting protein 120B, which is induced in relation to myogenesis, binds to NOT3. (PubMed id 12207886) 1 , 9(2002) Proteolytic targeting of transcriptional regulator TIP120B by a HECT domain E3 ligase. (PubMed id 12692129) 1 , 9(2003) Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844) 1 (2012) Global landscape of HIV-human protein complexes. (PubMed id 22190034) 1 (2012) Interplay between two myogenesis-related proteins: TBP -interacting protein 120B and MyoD. (PubMed id 22613845) 1 (2012) Initial characterization of the human central proteome. (PubMed id 21269460) 2 (2011)
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External Searches for CAND2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CAND2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CAND2 gene
(According to HUGE )
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Specialized Databases showing CAND2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for CAND2 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for CAND2 gene: CAND2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CAND2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for CAND2 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for CAND2 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for CAND2 OriGene 3'-UTR Clone for CAND2 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for CAND2 OriGene Custom Protein Services for CAND2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CAND2 Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CAND2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAND2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
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CAND2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAND2
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CAND2
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Aliases for CAND2
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Disorders / Diseases for CAND2
Domains / Families for CAND2
Drugs / Compounds for CAND2
Expression for CAND2
Function for CAND2
Genomic Views for CAND2
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Expression by the Database of Embryonic development, Stem cell research, and
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Anatomical Compartment 
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