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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CAND2 Gene

protein-coding   GIFtS: 51
GCID: GC03P012814

Cullin-Associated And Neddylation-Dissociated 2 (Putative)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cullin-Associated And Neddylation-Dissociated 2 (Putative)1 2     TBP-Interacting Protein 120B2 3
TBP Interacting Protein1 2     TBP-Interacting Protein Of 120 KDa B2 3
Cullin-Associated And Neddylation-Dissociated Protein 22 3     Tp120b2
Epididymis Tissue Protein Li 1692 3     Cullin-Associated NEDD8-Dissociated Protein 22
TIP120B2 3     KIAA06673
P120 CAND22 3     

External Ids:    HGNC: 306891   Entrez Gene: 230662   Ensembl: ENSG000001447127   OMIM: 6104035   UniProtKB: O751553   

Export aliases for CAND2 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CAND2 Gene: 
CAND2 (cullin-associated and neddylation-dissociated 2 (putative)) is a protein-coding gene. Diseases associated with CAND2 include clubfoot, and epididymitis. GO annotations related to this gene include TBP-class protein binding and protein binding. An important paralog of this gene is CAND1.

UniProtKB/Swiss-Prot: CAND2_HUMAN, O75155
Function: Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes
the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the
cellular repertoire of SCF complexes (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CAND2 gene promoter:
         RFX1   ATF-2   Pax-2   FOXD1   Pax-2a   CREB   deltaCREB   c-Jun   MRF-2   En-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CAND2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAND2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.2   Ensembl cytogenetic band:  3p25.2   HGNC cytogenetic band: 3p25.2

CAND2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAND2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P012814:  view genomic region     (about GC identifiers)

Start:
12,837,971 bp from pter      End:
12,913,415 bp from pter
Size:
75,445 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CAND2_HUMAN, O75155 (See protein sequence)
Recommended Name: Cullin-associated NEDD8-dissociated protein 2  
Size: 1236 amino acids; 135256 Da
Subunit: Binds TBP, CNOT3 and UBE3C (By similarity)
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=AAI36593.1; Type=Erroneous initiation;
Secondary accessions: B9EGM9 E9KL24
Alternative splicing: 2 isoforms:  O75155-1   O75155-2   

Explore the universe of human proteins at neXtProt for CAND2: NX_O75155

Explore proteomics data for CAND2 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated and targeted for proteasomal degradation (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75155

  • CAND2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CAND2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001155971.1  NP_036430.1  

    ENSEMBL proteins: 
     ENSP00000295989   ENSP00000390996   ENSP00000387641   ENSP00000403093  

    Human Recombinant Protein Products for CAND2: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CAND2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA12692129
    GO:0005634nucleus IEA--

    CAND2 for ontologies           About GeneDecksing



    CAND2 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for CAND2 
    Cloud-Clone Corp. CLIAs for CAND2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR011989 ARM-like
     IPR013932 TATA-bd_TIP120
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry O75155

    ProtoNet protein and cluster: O75155

    2 Blocks protein domains:
    IPB000357 HEAT repeat
    IPB013932 TATA-binding protein interacting (TIP20)


    UniProtKB/Swiss-Prot: CAND2_HUMAN, O75155
    Similarity: Belongs to the CAND family
    Similarity: Contains 26 HEAT repeats


    CAND2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAND2_HUMAN, O75155
    Function: Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes
    the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the
    cellular repertoire of SCF complexes (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI12207886
    GO:0017025TBP-class protein binding IEA--
         
    CAND2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CAND2:
     Increased G1 DNA content  Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Cand2):
     homeostasis/metabolism 

    CAND2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CAND2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAND2 
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    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate CAND2:
    hsa-miR-4324 hsa-miR-544b hsa-miR-124 hsa-miR-506 hsa-miR-490-3p hsa-miR-4308
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAND2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CAND2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/9 Interacting proteins for CAND2 (O751553 ENSP000002959894) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CNOT3O751753, ENSP000002212324I2D: score=2 STRING: ENSP00000221232
    CUL1Q136163, ENSP000003268044I2D: score=2 STRING: ENSP00000326804
    TBPP202263, ENSP000002303544I2D: score=1 STRING: ENSP00000230354
    UBE3CQ153863, ENSP000003091984I2D: score=2 STRING: ENSP00000309198
    TLN1Q9Y4903I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0045893positive regulation of transcription, DNA-dependent ISS--

    CAND2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CAND2

    Search CenterWatch for drugs/clinical trials and news about CAND2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CAND2 gene (2 alternative transcripts): 
    NM_001162499.1  NM_012298.2  

    Unigene Cluster for CAND2:

    Cullin-associated and neddylation-dissociated 2 (putative)
    Hs.343664  [show with all ESTs]
    Unigene Representative Sequence: NM_001162499
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295989(uc003bxj.2) ENST00000446928 ENST00000456430(uc003bxk.2)
    ENST00000466558 ENST00000454887
    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate CAND2:
    hsa-miR-4324 hsa-miR-544b hsa-miR-124 hsa-miR-506 hsa-miR-490-3p hsa-miR-4308
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAND2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAND2
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAND2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAND2

    Additional mRNA sequence: 

    AB014567.1 BC136592.1 BX648800.1 GU727621.1 

    9 DOTS entries:

    DT.100052296  DT.40259348  DT.99945073  DT.75172612  DT.70102741  DT.75197842  DT.120880916  DT.120880991 
    DT.99975813 

    24/62 AceView cDNA sequences (see all 62):

    AI699404 AL079841 CR613433 BE857394 BQ188038 BG696221 AB014567 AI914159 
    AI698215 F09289 AI086921 AL045550 BM985429 AA971779 AI039805 BE783517 
    BU736736 BG396611 AL538276 AI373183 BX648800 BX451616 BX502783 AI052287 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CAND2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15
    SP1:                    -     -     -                                                     -                           
    SP2:                                                                                                                  
    SP3:                                -                                                                                 
    SP4:                    -     -                                                                                       


    ECgene alternative splicing isoforms for CAND2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CAND2 expression in normal human tissues (normalized intensities)      CAND2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CAND2 Expression
    About this image


    CAND2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Blood Brain Barrier (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Heart (Cardiovascular System)

    See CAND2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CAND2

    SOURCE GeneReport for Unigene cluster: Hs.343664

    UniProtKB/Swiss-Prot: CAND2_HUMAN, O75155
    Tissue specificity: Expressed in epididymis (at protein level)

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAND2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CAND2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cand21 , 5 cullin-associated and neddylation-dissociated 2 (putative)1, 5 85.86(n)1
    90.69(a)1
      6 (53.71 cM)5
    670881  NM_025958.21  NP_080234.21 
     1157745385 
    chicken
    (Gallus gallus)
    Aves CAND26
    cullin-associated and neddylation-dissociated 2 (p...
    68(a)
    1 ↔ 1
    12(19444973-19459421)
    lizard
    (Anolis carolinensis)
    Reptilia CAND26
    Uncharacterized protein
    64(a)
    1 ↔ 1
    GL343273.1(809940-839561)
    zebrafish
    (Danio rerio)
    Actinopterygii cand26
    cullin-associated and neddylation-dissociated 2 (p...
    59(a)
    1 ↔ 1
    22(33734811-33748937)
    fruit fly
    (Drosophila melanogaster)
    Insecta Cand16
    Cullin-associated and neddylation-dissociated 1
    51(a)
    1 → many
    2L(10358134-10362707)
    worm
    (Caenorhabditis elegans)
    Secernentea cand-16
    Protein CAND-1
    33(a)
    1 → many
    V(16802874-16814563)


    ENSEMBL Gene Tree for CAND2 (if available)
    TreeFam Gene Tree for CAND2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CAND2 gene
    CAND12  
    1 SIMAP similar gene for CAND2 using alignment to 3 protein entries:     CAND2_HUMAN (see all proteins):
    CAND1

    CAND2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1098 SNPs in CAND2 are shown (see all 1098)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1117875741,2
    C,F--12836511(+) CTGCTC/GCCTCT 2 -- us2k13Minor allele frequency- G:0.03CSA WA NA 239
    rs1819113011,2
    --12836520(+) CTGTCA/TGGGAA 2 -- us2k10--------
    rs1854606451,2
    --12836736(+) AGTCCC/TCAGGG 2 -- us2k10--------
    rs1898730781,2
    --12836743(+) AGGGGA/GCAGGG 2 -- us2k10--------
    rs40349421,2
    C,F,A,H--12836792(-) GATCTG/ATACAA 2 -- us2k124Minor allele frequency- A:0.46NS EA NA WA CSA 2353
    rs738135511,2
    C,F--12836802(+) CTGCAC/TTGTCC 2 -- us2k16Minor allele frequency- T:0.07WA CSA NA EA 364
    rs1806802301,2
    --12836991(+) CAGTGG/TTCTAT 2 -- us2k10--------
    rs30433061,2
    C--12837066(-) AAAAA-/A/AA  
            
    TCTTT
    2 -- us2k11NA 2
    rs3701630101,2
    C--12837066(+) TAAAG-/TTTTTTT 2 -- us2k10--------
    rs1866513081,2
    --12837100(+) GCTCTA/GTCGCC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CAND2 (12837971 - 12913415 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CAND2:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv850e199CNV Deletion23128226
    dgv810e201CNV Deletion23290073
    nsv460435CNV Loss19166990
    esv2751977CNV Gain17911159
    nsv7351OTHER Inversion18451855

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610403    OMIM disorders: --

    2 diseases for CAND2:    About MalaCards
    clubfoot    epididymitis


    CAND2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CAND2
    Human Genome Epidemiology (HuGE) Navigator: CAND2 (1 document)

    Export disorders for CAND2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CAND2 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with CAND2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (1998)
    2. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PubMed id 20736409)1, 2 Li J.... Liu Y. (2010)
    3. Evaluation of CAND2 and WNT7a as candidate genes for congenital idiopathic clubfoot. (PubMed id 19159115)1, 4 Shyy W....Morcuende J.A. (2009)
    4. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (2006)
    5. TIP120B: a novel TIP120-family protein that is expres sed specifically in muscle tissues. (PubMed id 10441524)1, 3 Aoki T....Tamura T.A. (1999)
    6. TBP-interacting protein 120B, which is induced in relation to myogenesis, binds to NOT3. (PubMed id 12207886)1, 9 Aoki T.... Tamura T.-A. (2002)
    7. Proteolytic targeting of transcriptional regulator TIP120B by a HECT domain E3 ligase. (PubMed id 12692129)1, 9 You J.... Pickart C.M. (2003)
    8. The Identification of Novel Proteins That Interact Wit h the GLP-1 Receptor and Restrain its Activity. (PubMed id 23864651)1 Huang X....Wheeler M.B. (2013)
    9. Characterization of carbonic anhydrase IX interactome reveals proteins assisting its nuclear localization in hypoxic cells. (PubMed id 23181366)1 Buanne P....Zambrano N. (2013)
    10. Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23066 HGNC: 30689 AceView: TIP120B Ensembl:ENSG00000144712 euGenes: HUgn23066
    ECgene: CAND2 H-InvDB: CAND2

    (According to HUGE)
    About This Section
    HUGE: KIAA0667

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CAND2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CAND2 gene:
    Search GeneIP for patents involving CAND2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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