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Aliases for CAND1 Gene

Aliases for CAND1 Gene

  • Cullin-Associated And Neddylation-Dissociated 1 2 3
  • TIP120A 3 4 6
  • TIP120 3 4 6
  • Cullin-Associated And Neddylation-Dissociated Protein 1 3 4
  • TBP-Interacting Protein Of 120 KDa A 3 4
  • TBP-Interacting Protein 120A 3 4
  • TBP Interacting Protein 2 3
  • P120 CAND1 3 4
  • KIAA0829 4 6
  • Cullin-Associated NEDD8-Dissociated Protein 1 3

External Ids for CAND1 Gene

Summaries for CAND1 Gene

GeneCards Summary for CAND1 Gene

CAND1 (Cullin-Associated And Neddylation-Dissociated 1) is a Protein Coding gene. Among its related pathways are Protein Stability. GO annotations related to this gene include TBP-class protein binding. An important paralog of this gene is CAND2.

UniProtKB/Swiss-Prot for CAND1 Gene

  • Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes.

Gene Wiki entry for CAND1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAND1 Gene

Genomics for CAND1 Gene

Genomic Location for CAND1 Gene

Start:
67,269,281 bp from pter
End:
67,319,951 bp from pter
Size:
50,671 bases
Orientation:
Plus strand

Genomic View for CAND1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAND1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAND1 Gene

Regulatory Elements for CAND1 Gene

Proteins for CAND1 Gene

  • Protein details for CAND1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VP6-CAND1_HUMAN
    Recommended name:
    Cullin-associated NEDD8-dissociated protein 1
    Protein Accession:
    Q86VP6
    Secondary Accessions:
    • B2RAU3
    • O94918
    • Q6PIY4
    • Q8NDJ4
    • Q96JZ9
    • Q96T19
    • Q9BTC4
    • Q9H0G2
    • Q9P0H7
    • Q9UF85

    Protein attributes for CAND1 Gene

    Size:
    1230 amino acids
    Molecular mass:
    136376 Da
    Quaternary structure:
    • Interacts with TBP (By similarity). Part of a complex that contains CUL1 and RBX1. Interacts with unneddylated cullins: interacts with CUL1, CUL2, CUL3, CUL4A, CUL4B and CUL5. Does not bind neddylated CUL1. Interaction with cullins is abolished in presence of COMMD1, which antagonizes with CAND1 for interacting with cullins. Interacts with DCUN1D3.
    Miscellaneous:
    • A model has been proposed to explain the mechanisms of cullin-RING E3 ubiquitin ligase complexes assembly. According to this hypothesis, cullin-RING E3 ubiquitin ligase complexes exist in a stable active state when saturated with substrate, occluding access to deneddylation by the COP9 signalosome (CSN) complex. The neddylation-conjugated cullin-RING E3 ubiquitin ligase complexes mediate ubiquitination of substrates and can recruit downstream factors involved in substrate degradation. Depletion of the substrate promotes the ability of CSN to bind the cullin-RING E3 ubiquitin ligase complex and mediate deneddylation. In this intermediate deneddylated state, the complex can bind CAND1 and enter the exchange state, resulting in high increase in dissociation rate of the substrate-recognition subunit. The resulting CAND1-cullin-RING complex rapidly assembles with another available substrate-recognition subunit to form an unstable ternary intermediate and yield a new cullin-RING E3 ubiquitin ligase complex. Subsequent neddylation of the cullin, which is stabilized by substrate, completes the cycle (PubMed:23453757).
    SequenceCaution:
    • Sequence=BAA74852.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB55090.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CAND1 Gene

    Alternative splice isoforms for CAND1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAND1 Gene

Proteomics data for CAND1 Gene at MOPED

Post-translational modifications for CAND1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys14, Lys20, Lys51, Lys55, Lys255, Lys355, Lys373, Lys403, Lys630, Lys826, Lys957, and Lys1037

Other Protein References for CAND1 Gene

No data available for DME Specific Peptides for CAND1 Gene

Domains for CAND1 Gene

Protein Domains for CAND1 Gene

Suggested Antigen Peptide Sequences for CAND1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86VP6

UniProtKB/Swiss-Prot:

CAND1_HUMAN
Family:
  • Belongs to the CAND family.:
    • Q86VP6
Similarity:
  • Contains 27 HEAT repeats.:
    • Q86VP6
genes like me logo Genes that share domains with CAND1: view

No data available for Gene Families for CAND1 Gene

Function for CAND1 Gene

Molecular function for CAND1 Gene

UniProtKB/Swiss-Prot Function: Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes.
UniProtKB/Swiss-Prot Induction: Repressed by miR-148a.

Gene Ontology (GO) - Molecular Function for CAND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 12504025
GO:0017025 TBP-class protein binding IEA --
genes like me logo Genes that share ontologies with CAND1: view

Phenotypes for CAND1 Gene

GenomeRNAi human phenotypes for CAND1:
genes like me logo Genes that share phenotypes with CAND1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CAND1 Gene

Localization for CAND1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAND1 Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAND1 Gene COMPARTMENTS Subcellular localization image for CAND1 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for CAND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 12609982
GO:0005634 nucleus IDA 10581176
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 21249194
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with CAND1: view

Pathways for CAND1 Gene

SuperPathways for CAND1 Gene

Superpath Contained pathways
1 Protein Stability
genes like me logo Genes that share pathways with CAND1: view

Pathways by source for CAND1 Gene

1 Cell Signaling Technology pathway for CAND1 Gene

Gene Ontology (GO) - Biological Process for CAND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010265 SCF complex assembly IDA 15537541
GO:0016567 protein ubiquitination IDA 12609982
GO:0030154 cell differentiation IDA 10581176
GO:0043086 negative regulation of catalytic activity IDA 12609982
GO:0045893 positive regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with CAND1: view

Transcripts for CAND1 Gene

Unigene Clusters for CAND1 Gene

Cullin-associated and neddylation-dissociated 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAND1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b
SP1: - - - - - -
SP2: -
SP3: - -
SP4:
SP5: -
SP6:

Relevant External Links for CAND1 Gene

GeneLoc Exon Structure for
CAND1
ECgene alternative splicing isoforms for
CAND1

Expression for CAND1 Gene

mRNA expression in normal human tissues for CAND1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CAND1 Gene

SOURCE GeneReport for Unigene cluster for CAND1 Gene Hs.546407

genes like me logo Genes that share expressions with CAND1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CAND1 Gene

Orthologs for CAND1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAND1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAND1 35
  • 99.67 (n)
  • 99.92 (a)
CAND1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CAND1 35
  • 95.2 (n)
  • 100 (a)
CAND1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAND1 35
  • 95.23 (n)
  • 99.75 (a)
CAND1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cand1 35
  • 89.32 (n)
  • 99.43 (a)
Cand1 16
Cand1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CAND1 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAND1 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cand1 35
  • 90.68 (n)
  • 99.76 (a)
chicken
(Gallus gallus)
Aves CAND1 35
  • 86.18 (n)
  • 98.67 (a)
CAND1 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAND1 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cand1 35
  • 81.76 (n)
  • 97.8 (a)
zebrafish
(Danio rerio)
Actinopterygii cand1 35
  • 76.31 (n)
  • 93.82 (a)
cand1 36
  • 94 (a)
OneToOne
wufa93g07 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009970 35
  • 56.23 (n)
  • 62.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cand1 35
  • 56.22 (n)
  • 59.57 (a)
Cand1 36
  • 58 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cand-1 35
  • 48.87 (n)
  • 39.37 (a)
cand-1 36
  • 36 (a)
OneToMany
corn
(Zea mays)
Liliopsida Zm.6443 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToMany
Species with no ortholog for CAND1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAND1 Gene

ENSEMBL:
Gene Tree for CAND1 (if available)
TreeFam:
Gene Tree for CAND1 (if available)

Paralogs for CAND1 Gene

Paralogs for CAND1 Gene

Selected SIMAP similar genes for CAND1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CAND1: view

Variants for CAND1 Gene

Sequence variations from dbSNP and Humsavar for CAND1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs710621 -- 67,271,091(-) TATTT(G/T)TTAAA intron-variant
rs710622 -- 67,271,059(-) ATTGA(C/T)TATTT intron-variant
rs710623 -- 67,270,198(-) GAGCA(A/C)GGCGG intron-variant
rs710629 -- 67,304,076(+) CCTCC(A/G)CCTCC intron-variant
rs710630 -- 67,303,537(-) TGTCT(A/G)ACTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAND1 Gene

Variant ID Type Subtype PubMed ID
nsv525023 CNV Loss 19592680
esv259573 OTHER Complex 20981092
esv259775 OTHER Complex 20981092
nsv756 CNV Loss 18451855
esv8315 CNV Gain 19470904

Relevant External Links for CAND1 Gene

HapMap Linkage Disequilibrium report
CAND1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAND1 Gene

Disorders for CAND1 Gene

Relevant External Links for CAND1

Genetic Association Database (GAD)
CAND1
genes like me logo Genes that share disorders with CAND1: view

No data available for UniProtKB/Swiss-Prot for CAND1 Gene

Publications for CAND1 Gene

  1. TIP120A associates with cullins and modulates ubiquitin ligase activity. (PMID: 12609982) Min K.-W. … Yoon J.-B. (J. Biol. Chem. 2003) 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  3. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  5. NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases. (PMID: 12504025) Liu J. … Xiong Y. (Mol. Cell 2002) 3 4

Products for CAND1 Gene

Sources for CAND1 Gene

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