Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CAND1 Gene

Aliases for CAND1 Gene

  • Cullin Associated And Neddylation Dissociated 1 2 3 5
  • TBP-Interacting Protein Of 120 KDa A 3 4
  • P120 CAND1 3 4
  • TIP120A 3 4
  • TIP120 3 4
  • Cullin-Associated And Neddylation-Dissociated Protein 1 4
  • Cullin-Associated And Neddylation-Dissociated 1 2
  • Cullin-Associated NEDD8-Dissociated Protein 1 3
  • TBP-Interacting Protein 120A 4
  • TBP Interacting Protein 2
  • KIAA0829 4

External Ids for CAND1 Gene

Previous GeneCards Identifiers for CAND1 Gene

  • GC12P065950
  • GC12P067663
  • GC12P064713

Summaries for CAND1 Gene

Entrez Gene Summary for CAND1 Gene

  • This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin ligase complex assembly and activity. In mammalian cell culture, this protein predominantly localizes to the cytoplasm. Knockdown of this gene in preadipocytes results in blocked adipogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]

GeneCards Summary for CAND1 Gene

CAND1 (Cullin Associated And Neddylation Dissociated 1) is a Protein Coding gene. Diseases associated with CAND1 include Familial Hypertension. Among its related pathways are Immune System. GO annotations related to this gene include binding and TBP-class protein binding. An important paralog of this gene is CAND2.

UniProtKB/Swiss-Prot for CAND1 Gene

  • Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes.

Gene Wiki entry for CAND1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAND1 Gene

Genomics for CAND1 Gene

Regulatory Elements for CAND1 Gene

Enhancers for CAND1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F067320 0.2 ENCODE 25.5 +51.8 51782 1.2 SOX13 PKNOX1 KLF17 SIN3A ZNF316 CTBP1 GATA3 ZNF366 PATZ1 FOS CAND1 GGTA2P GC12P067317 MRPL40P1
GH12F067354 0.7 Ensembl ENCODE 25.5 +85.3 85321 0.8 SOX13 ESRRA CEBPG ZNF644 RAD21 YY1 HNF4G FOS GATAD2A SOX5 CAND1 LOC105369812 MRPL40P1
GH12F067267 0.6 ENCODE 23.4 +0.7 659 4.6 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 CAND1 GC12P067317
GH12F067274 0.5 Ensembl 15.1 +5.7 5720 2.0 RARA TEAD3 GATA3 MTA3 CTBP1 SCRT2 PRDM10 FOS ZNF600 TCF7L2 CAND1 GC12P067317
GH12F067067 0.5 ENCODE 15.1 -200.1 -200135 2.8 CTCF PKNOX1 SIN3A RAD21 ZNF2 E2F1 ZFHX2 GLIS2 ZBTB48 POLR2A CAND1 GGTA2P GRIP1 ENSG00000256248 ENSG00000279310
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CAND1 on UCSC Golden Path with GeneCards custom track

Promoters for CAND1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000432385 720 4400 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for CAND1 Gene

Chromosome:
12
Start:
67,269,281 bp from pter
End:
67,319,951 bp from pter
Size:
50,671 bases
Orientation:
Plus strand

Genomic View for CAND1 Gene

Genes around CAND1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAND1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAND1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAND1 Gene

Proteins for CAND1 Gene

  • Protein details for CAND1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VP6-CAND1_HUMAN
    Recommended name:
    Cullin-associated NEDD8-dissociated protein 1
    Protein Accession:
    Q86VP6
    Secondary Accessions:
    • B2RAU3
    • O94918
    • Q6PIY4
    • Q8NDJ4
    • Q96JZ9
    • Q96T19
    • Q9BTC4
    • Q9H0G2
    • Q9P0H7
    • Q9UF85

    Protein attributes for CAND1 Gene

    Size:
    1230 amino acids
    Molecular mass:
    136376 Da
    Quaternary structure:
    • Interacts with TBP (By similarity). Part of a complex that contains CUL1 and RBX1. Interacts with unneddylated cullins: interacts with CUL1, CUL2, CUL3, CUL4A, CUL4B and CUL5. Does not bind neddylated CUL1. Interaction with cullins is abolished in presence of COMMD1, which antagonizes with CAND1 for interacting with cullins. Interacts with DCUN1D3.
    Miscellaneous:
    • A model has been proposed to explain the mechanisms of cullin-RING E3 ubiquitin ligase complexes assembly. According to this hypothesis, cullin-RING E3 ubiquitin ligase complexes exist in a stable active state when saturated with substrate, occluding access to deneddylation by the COP9 signalosome (CSN) complex. The neddylation-conjugated cullin-RING E3 ubiquitin ligase complexes mediate ubiquitination of substrates and can recruit downstream factors involved in substrate degradation. Depletion of the substrate promotes the ability of CSN to bind the cullin-RING E3 ubiquitin ligase complex and mediate deneddylation. In this intermediate deneddylated state, the complex can bind CAND1 and enter the exchange state, resulting in high increase in dissociation rate of the substrate-recognition subunit. The resulting CAND1-cullin-RING complex rapidly assembles with another available substrate-recognition subunit to form an unstable ternary intermediate and yield a new cullin-RING E3 ubiquitin ligase complex. Subsequent neddylation of the cullin, which is stabilized by substrate, completes the cycle (PubMed:23453757).
    SequenceCaution:
    • Sequence=BAA74852.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB55090.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CAND1 Gene

    Alternative splice isoforms for CAND1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAND1 Gene

Post-translational modifications for CAND1 Gene

  • Ubiquitination at Lys 14, Lys 51, Lys 55, Lys 255, Lys 355, Lys 373, Lys 403, Lys 630, Lys 826, Lys 957, and Lys 1037
  • Modification sites at PhosphoSitePlus

Other Protein References for CAND1 Gene

No data available for DME Specific Peptides for CAND1 Gene

Domains & Families for CAND1 Gene

Suggested Antigen Peptide Sequences for CAND1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86VP6

UniProtKB/Swiss-Prot:

CAND1_HUMAN :
  • Belongs to the CAND family.
  • Contains 27 HEAT repeats.
Family:
  • Belongs to the CAND family.
Similarity:
  • Contains 27 HEAT repeats.
genes like me logo Genes that share domains with CAND1: view

No data available for Gene Families for CAND1 Gene

Function for CAND1 Gene

Molecular function for CAND1 Gene

UniProtKB/Swiss-Prot Function:
Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes.
UniProtKB/Swiss-Prot Induction:
Repressed by miR-148a.

Gene Ontology (GO) - Molecular Function for CAND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12504025
GO:0017025 TBP-class protein binding IEA --
genes like me logo Genes that share ontologies with CAND1: view
genes like me logo Genes that share phenotypes with CAND1: view

Animal Model Products

miRNA for CAND1 Gene

miRTarBase miRNAs that target CAND1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CAND1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CAND1 Gene

Localization for CAND1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAND1 Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAND1 Gene COMPARTMENTS Subcellular localization image for CAND1 gene
Compartment Confidence
extracellular 5
nucleus 5
golgi apparatus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for CAND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 12609982
GO:0005634 nucleus IEA,IDA 10581176
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 21249194
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with CAND1: view

Pathways & Interactions for CAND1 Gene

SuperPathways for CAND1 Gene

SuperPathway Contained pathways
1 Immune System
genes like me logo Genes that share pathways with CAND1: view

Pathways by source for CAND1 Gene

2 Reactome pathways for CAND1 Gene

Gene Ontology (GO) - Biological Process for CAND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010265 SCF complex assembly IDA 15537541
GO:0016567 protein ubiquitination IDA 12609982
GO:0030154 cell differentiation IDA 10581176
GO:0043086 negative regulation of catalytic activity IDA 12609982
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with CAND1: view

No data available for SIGNOR curated interactions for CAND1 Gene

Transcripts for CAND1 Gene

Unigene Clusters for CAND1 Gene

Cullin-associated and neddylation-dissociated 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CAND1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAND1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b
SP1: - - - - - -
SP2: -
SP3: - -
SP4:
SP5: -
SP6:

Relevant External Links for CAND1 Gene

GeneLoc Exon Structure for
CAND1
ECgene alternative splicing isoforms for
CAND1

Expression for CAND1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CAND1 Gene

Protein differential expression in normal tissues from HIPED for CAND1 Gene

This gene is overexpressed in Bone (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CAND1 Gene



Protein tissue co-expression partners for CAND1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CAND1 Gene:

CAND1

SOURCE GeneReport for Unigene cluster for CAND1 Gene:

Hs.546407
genes like me logo Genes that share expression patterns with CAND1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CAND1 Gene

Orthologs for CAND1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAND1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAND1 34 35
  • 99.67 (n)
oppossum
(Monodelphis domestica)
Mammalia CAND1 35
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAND1 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAND1 34 35
  • 95.23 (n)
cow
(Bos Taurus)
Mammalia CAND1 34 35
  • 95.2 (n)
rat
(Rattus norvegicus)
Mammalia Cand1 34
  • 90.68 (n)
mouse
(Mus musculus)
Mammalia Cand1 34 16 35
  • 89.32 (n)
chicken
(Gallus gallus)
Aves CAND1 34 35
  • 86.18 (n)
lizard
(Anolis carolinensis)
Reptilia CAND1 35
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cand1 34
  • 81.76 (n)
zebrafish
(Danio rerio)
Actinopterygii cand1 34 35
  • 76.31 (n)
wufa93g07 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009970 34
  • 56.23 (n)
fruit fly
(Drosophila melanogaster)
Insecta Cand1 34 35
  • 56.22 (n)
worm
(Caenorhabditis elegans)
Secernentea cand-1 34 35
  • 48.87 (n)
corn
(Zea mays)
Liliopsida Zm.6443 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 53 (a)
OneToMany
Species where no ortholog for CAND1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAND1 Gene

ENSEMBL:
Gene Tree for CAND1 (if available)
TreeFam:
Gene Tree for CAND1 (if available)

Paralogs for CAND1 Gene

Paralogs for CAND1 Gene

(1) SIMAP similar genes for CAND1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CAND1: view

Variants for CAND1 Gene

Sequence variations from dbSNP and Humsavar for CAND1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs193921038 Uncertain significance 67,297,652(+) AGCTG(A/G)TCATA reference, missense
rs10506543 -- 67,312,955(+) CTTCA(C/T)GGAGA utr-variant-3-prime
rs10573806 -- 67,270,770(+) AATCT(-/A)AAAAA intron-variant
rs1060350 -- 67,312,686(+) GCACT(A/G)CTAAC reference, synonymous-codon
rs10713081 -- 67,300,281(+) AACTT(-/A)ACCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAND1 Gene

Variant ID Type Subtype PubMed ID
dgv857e59 CNV tandem duplication 20981092
esv3341682 CNV duplication 20981092
esv3407176 CNV duplication 20981092
esv3580303 CNV loss 25503493
esv3629822 CNV loss 21293372
esv3629823 CNV loss 21293372
esv3629825 CNV loss 21293372
esv8315 CNV gain 19470904
nsv1054111 CNV gain 25217958
nsv1142141 CNV tandem duplication 24896259
nsv1152456 CNV insertion 26484159
nsv525023 CNV loss 19592680
nsv559212 CNV gain 21841781
nsv756 CNV deletion 18451855

Variation tolerance for CAND1 Gene

Residual Variation Intolerance Score: 2.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.67; 31.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAND1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAND1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAND1 Gene

Disorders for CAND1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CAND1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
familial hypertension
  • genetic hypertension
- elite association - COSMIC cancer census association via MalaCards
Search CAND1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CAND1

Genetic Association Database (GAD)
CAND1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAND1
genes like me logo Genes that share disorders with CAND1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAND1 Gene

Publications for CAND1 Gene

  1. TIP120A associates with cullins and modulates ubiquitin ligase activity. (PMID: 12609982) Min K.-W. … Yoon J.-B. (J. Biol. Chem. 2003) 3 4 22 64
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
  3. SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1). (PMID: 25349211) Huang G. … Singh B. (J. Biol. Chem. 2014) 3 4 64
  4. Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins. (PMID: 23453757) Pierce N.W. … Deshaies R.J. (Cell 2013) 3 4 64
  5. Regulation of cullin RING E3 ubiquitin ligases by CAND1 in vivo. (PMID: 21249194) Chua Y.S. … Hagen T. (PLoS ONE 2011) 3 4 64

Products for CAND1 Gene

Sources for CAND1 Gene

Content
Loading form....