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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CAND1 Gene

protein-coding   GIFtS: 56
GCID: GC12P067663

Cullin-Associated And Neddylation-Dissociated 1

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cullin-Associated And Neddylation-Dissociated 11 2     P120 CAND12 3
TBP Interacting Protein1 2     TBP-Interacting Protein 120A2 3
Cullin-Associated And Neddylation-Dissociated Protein 12 3     TBP-Interacting Protein Of 120 KDa A2 3
TIP1202 3     Cullin-Associated NEDD8-Dissociated Protein 12
TIP120A2 3     KIAA08293

External Ids:    HGNC: 306881   Entrez Gene: 558322   Ensembl: ENSG000001115307   OMIM: 6077275   UniProtKB: Q86VP63   

Export aliases for CAND1 gene to outside databases

Previous GC identifers: GC12P065950 GC12P064713


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CAND1 Gene: 
CAND1 (cullin-associated and neddylation-dissociated 1) is a protein-coding gene. Diseases associated with CAND1 include glomuvenous malformation, and alzheimer's disease. GO annotations related to this gene include TBP-class protein binding and protein binding. An important paralog of this gene is CAND2.

UniProtKB/Swiss-Prot: CAND1_HUMAN, Q86VP6
Function: Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the
exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular
repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled
with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1,
increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar
role in other cullin-RING E3 ubiquitin ligase complexes

Gene Wiki entry for CAND1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CAND1 gene promoter:
         Sox5   AML1a   Pax-2   Pax-2a   HNF-4alpha2   CUTL1   Ik-3   HNF-4alpha1   c-Myb   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCAND1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CAND1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAND1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14   Ensembl cytogenetic band:  12q14.3   HGNC cytogenetic band: 12q14

CAND1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAND1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P067663:  view genomic region     (about GC identifiers)

Start:
67,663,061 bp from pter      End:
67,713,731 bp from pter
Size:
50,671 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CAND1_HUMAN, Q86VP6 (See protein sequence)
Recommended Name: Cullin-associated NEDD8-dissociated protein 1  
Size: 1230 amino acids; 136376 Da
Subunit: Interacts with TBP (By similarity). Part of a complex that contains CUL1 and RBX1. Interacts with
unneddylated cullins: interacts with CUL1, CUL2, CUL3, CUL4A, CUL4B and CUL5. Does not bind neddylated CUL1.
Interaction with cullins is abolished in presence of COMMD1, which antagonizes with CAND1 for interacting with
cullins
Subcellular location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic
Miscellaneous: A model has been proposed to explain the mechanisms of cullin-RING E3 ubiquitin ligase complexes
assembly. According to this hypothesis, cullin-RING E3 ubiquitin ligase complexes exist in a 'stable' active
state when saturated with substrate, occluding access to deneddylation by the COP9 signalosome (CSN) complex. The
neddylation-conjugated cullin-RING E3 ubiquitin ligase complexes mediate ubiquitination of substrates and can
recruit downstream factors involved in substrate degradation. Depletion of the substrate promotes the ability of
CSN to bind the cullin-RING E3 ubiquitin ligase complex and mediate deneddylation. In this 'intermediate'
deneddylated state, the complex can bind CAND1 and enter the 'exchange' state, resulting in high increase in
dissociation rate of the substrate-recognition subunit. The resulting CAND1-cullin-RING complex rapidly assembles
with another available substrate-recognition subunit to form an unstable ternary intermediate and yield a new
cullin-RING E3 ubiquitin ligase complex. Subsequent neddylation of the cullin, which is stabilized by substrate,
completes the cycle (PubMed:23453757)
Sequence caution: Sequence=BAA74852.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB55090.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
2 PDB 3D structures from and Proteopedia for CAND1:
1U6G (3D)        4A0C (3D)    
Secondary accessions: B2RAU3 O94918 Q6PIY4 Q8NDJ4 Q96JZ9 Q96T19 Q9BTC4 Q9H0G2 Q9P0H7 Q9UF85
Alternative splicing: 3 isoforms:  Q86VP6-1   Q86VP6-2   Q86VP6-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CAND1: NX_Q86VP6

Explore proteomics data for CAND1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86VP6

  • CAND1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CAND1 Protein Expression
    REFSEQ proteins: NP_060918.2  
    ENSEMBL proteins: 
     ENSP00000442318   ENSP00000437594   ENSP00000445794   ENSP00000444089  

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    Cloud-Clone Corp. Proteins for CAND1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IDA12609982
    GO:0005634nucleus IDA10581176
    GO:0005737cytoplasm IDA--
    GO:0031461cullin-RING ubiquitin ligase complex IDA15537541

    CAND1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR011989 ARM-like
     IPR013932 TATA-bd_TIP120
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q86VP6

    ProtoNet protein and cluster: Q86VP6

    2 Blocks protein domains:
    IPB000357 HEAT repeat
    IPB013932 TATA-binding protein interacting (TIP20)


    UniProtKB/Swiss-Prot: CAND1_HUMAN, Q86VP6
    Similarity: Belongs to the CAND family
    Similarity: Contains 27 HEAT repeats


    CAND1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAND1_HUMAN, Q86VP6
    Function: Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the
    exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular
    repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled
    with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1,
    increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar
    role in other cullin-RING E3 ubiquitin ligase complexes
    Induction: Repressed by miR-148a

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI12504025
    GO:0017025TBP-class protein binding IEA--
         
    CAND1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CAND1:
     Increased cell death HMECs cel 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidCAND1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CAND1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Protein Stability
    Protein Stability

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CAND1
        Protein Stability




    CAND1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CAND1

    5/606 Interacting proteins for CAND1 (Q86VP61, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 606)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CUL1Q136161, 2, 3EBI-456077,EBI-359390 MINT-4304052 MINT-7945693 I2D: score=7 
    CUL2Q136171, 3EBI-456077,EBI-456179 I2D: score=5 
    CUL4BQ136201, 3EBI-456077,EBI-456067 I2D: score=5 
    CUL3Q136181, 3EBI-456077,EBI-456129 I2D: score=4 
    CUL4AQ136191, 3EBI-456077,EBI-456106 I2D: score=4 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010265SCF complex assembly IDA15537541
    GO:0016567protein ubiquitination IDA12609982
    GO:0030154cell differentiation IDA10581176
    GO:0043086negative regulation of catalytic activity IDA12609982
    GO:0045893positive regulation of transcription, DNA-dependent ----

    CAND1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CAND1

    Search CenterWatch for drugs/clinical trials and news about CAND1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CAND1 gene: 
    NM_018448.3  

    Unigene Cluster for CAND1:

    Cullin-associated and neddylation-dissociated 1
    Hs.546407  [show with all ESTs]
    Unigene Representative Sequence: NM_018448
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000545606(uc001stn.2 uc001sto.2) ENST00000541058 ENST00000539109
    ENST00000539434 ENST00000540525 ENST00000535146 ENST00000540319 ENST00000544619


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    Additional mRNA sequence: 

    AB020636.2 AF157326.1 AK000976.1 AK001791.1 AK027404.1 AK027783.1 AK074922.1 AK096010.1 
    AK129780.1 AK292456.1 AK314358.1 AL133560.1 AL136810.1 AL833880.2 BC004232.1 BC026220.2 
    BC050341.1 

    15 DOTS entries:

    DT.316271  DT.100826732  DT.100826735  DT.100826724  DT.121152839  DT.316269  DT.70100724  DT.430793 
    DT.95234856  DT.121152825  DT.121152844  DT.121152886  DT.91758056  DT.91794617  DT.99988370 

    24/392 AceView cDNA sequences (see all 392):

    BF593592 BE779777 BM833059 CB131333 N47219 BX281977 BC004232 BQ213715 
    AA491234 AI205537 AA744806 CA771949 BQ640517 AA976015 BQ428404 BP377729 
    BM684111 AI128318 AL833880 CB111441 BG678210 AA514379 AK096010 AW503098 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CAND1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b
    SP1:              -           -           -     -                                                                       -     -                     
    SP2:                                                                                            -                                                   
    SP3:              -           -                                                                                                                     
    SP4:                                                                                                                                                
    SP5:              -                                                                                                                                 


    ECgene alternative splicing isoforms for CAND1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CAND1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTTACAAT
    CAND1 Expression
    About this image


    See CAND1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CAND1

    SOURCE GeneReport for Unigene cluster: Hs.546407
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CAND1 gene from 9/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cand11 , 5 cullin associated and neddylation disassociated 11, 5 89.32(n)1
    99.43(a)1
      10 (67.08 cM)5
    719021  NM_027994.11  NP_082270.11 
     1191992555 
    chicken
    (Gallus gallus)
    Aves CAND11 cullin-associated and neddylation-dissociated 1 86.18(n)
    98.67(a)
      417837  XM_416078.3  XP_416078.3 
    lizard
    (Anolis carolinensis)
    Reptilia CAND16
    Cullin-associated and neddylation-dissociated prot...
    98(a)
    1 ↔ 1
    GL343256.1(877695-909781)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia CF783134.12   -- 83.8(n)    CF783134.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa93g072 Danio rerio mRNA similar to TBP-interacting protein more 75.46(n)    BC047184.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cand11 Cullin-associated and neddylation-dissociated 1 56.79(n)
    60.31(a)
      34403  NM_135545.2  NP_609389.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cand-11 Protein CAND-1 48.69(n)
    39.25(a)
      180125  NM_074843.4  NP_507244.1 
    soybean
    (Glycine max)
    eudicotyledons 467953392   -- 71.01(n)  
    rice
    (Oryza sativa)
    Liliopsida AK069128.12   -- 72.35(n)    AK069128.1 


    ENSEMBL Gene Tree for CAND1 (if available)
    TreeFam Gene Tree for CAND1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CAND1 gene
    CAND22  
    1 SIMAP similar gene for CAND1 using alignment to 3 protein entries:     CAND1_HUMAN (see all proteins):
    CAND2

    CAND1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/921 SNPs in CAND1 are shown (see all 921)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs39707851,2
    C--67661205(-) acaca-/CACA/CACA
    CA
    /CACACACA
    NNNNN
    2 -- us2k1 cds11CSA 2
    rs788476181,2
    C--67661231(+) TGTGTG/TTTACA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1157641561,2
    F--67661383(+) TATTAC/TGTATA 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1909554941,2
    --67661436(+) CAGGCC/TGGAGT 1 -- us2k10--------
    rs111766641,2
    C--67661519(+) GAGTAG/ACTGTG 1 -- us2k14Minor allele frequency- A:0.35NA EA 244
    rs742357341,2
    C,F--67661696(+) TTACAT/CACATT 1 -- us2k12Minor allele frequency- C:0.09NA EA 240
    rs1828530641,2
    C--67661803(+) TATTGC/GCTGAC 1 -- us2k10--------
    rs1117928931,2
    F--67661805(+) TTGCCC/TGACTT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1437963131,2
    --67662168(+) CATCAA/GGGCCA 1 -- us2k10--------
    rs1866428191,2
    --67662219(+) ATCAGC/TAGGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CAND1 (67663061 - 67713731 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CAND1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv756CNV Loss18451855
    nsv525023CNV Loss19592680
    esv8315CNV Gain19470904
    esv259573OTHER Complex20981092
    esv259775OTHER Complex20981092

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607727    OMIM disorders: --

    4 diseases for CAND1:    About MalaCards
    glomuvenous malformation    alzheimer's disease    prostate cancer    prostatitis


    CAND1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): CAND1

    Export disorders for CAND1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CAND1 gene, integrated from 9 sources (see all 86):
    (articles sorted by number of sources associating them with CAND1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T....Ohara O. (1998)
    2. TIP120A associates with cullins and modulates ubiquitin ligase activity. (PubMed id 12609982)1, 2, 9 Min K.-W.... Yoon J.-B. (2003)
    3. Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins. (PubMed id 23453757)1, 2 Pierce N.W....Deshaies R.J. (2013)
    4. COMMD1 (copper metabolism MURR1 domain-containing pro tein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Ne dd8-dissociated protein 1) binding. (PubMed id 21778237)1, 2 Mao X....Burstein E. (2011)
    5. Regulation of cullin RING E3 ubiquitin ligases by CAN D1 in vivo. (PubMed id 21249194)1, 2 Chua Y.S....Hagen T. (2011)
    6. miR-148a is an androgen-responsive microRNA that prom otes LNCaP prostate cell growth by repressing its target CAND1 expression. (PubMed id 20820187)1, 2 Murata T....Inoue S. (2010)
    7. Hippocampal atrophy as a quantitative trait in a geno me-wide association study identifying novel susceptibility genes for Alzheimer' s disease. (PubMed id 19668339)1, 4 Potkin S.G....Macciardi F. (2009)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases. (PubMed id 15537541)1, 2 Goldenberg S.J.... Zheng N. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55832 HGNC: 30688 AceView: TIP120A Ensembl:ENSG00000111530 euGenes: HUgn55832
    ECgene: CAND1 H-InvDB: CAND1

    (According to HUGE)
    About This Section
    HUGE: KIAA0829

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CAND1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CAND1 gene:
    Search GeneIP for patents involving CAND1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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