Aliases for CAND1 Gene
External Ids for CAND1 Gene
Previous GeneCards Identifiers for CAND1 Gene
GeneCards Summary for CAND1 Gene
CAND1 (Cullin Associated And Neddylation Dissociated 1) is a Protein Coding gene. Diseases associated with CAND1 include familial hypertension. GO annotations related to this gene include binding and TBP-class protein binding. An important paralog of this gene is CAND2.
UniProtKB/Swiss-Prot for CAND1 Gene
Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes.