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CAND1 Gene

protein-coding   GIFtS: 56
GCID: GC12P067663

Cullin-Associated And Neddylation-Dissociated 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cullin-Associated And Neddylation-Dissociated 11 2     P120 CAND12 3
TIP1202 3 5     TBP-Interacting Protein 120A2 3
TIP120A2 3 5     TBP-Interacting Protein Of 120 KDa A2 3
TBP Interacting Protein1 2     KIAA08293 5
Cullin-Associated And Neddylation-Dissociated Protein 12 3     Cullin-Associated NEDD8-Dissociated Protein 12

External Ids:    HGNC: 306881   Entrez Gene: 558322   Ensembl: ENSG000001115307   OMIM: 6077275   UniProtKB: Q86VP63   

Export aliases for CAND1 gene to outside databases

Previous GC identifers: GC12P065950 GC12P064713


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CAND1 Gene:
CAND1 (cullin-associated and neddylation-dissociated 1) is a protein-coding gene. Diseases associated with CAND1 include glomuvenous malformation, and cystic fibrosis. GO annotations related to this gene include TBP-class protein binding. An important paralog of this gene is CAND2.

UniProtKB/Swiss-Prot: CAND1_HUMAN, Q86VP6
Function: Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the
exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular
repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled
with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1,
increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar
role in other cullin-RING E3 ubiquitin ligase complexes

Gene Wiki entry for CAND1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the CAND1 gene promoter:
         Sox5   AML1a   Pax-2   Pax-2a   HNF-4alpha2   CUTL1   Ik-3   HNF-4alpha1   c-Myb   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCAND1 promoter sequence
   Search Chromatin IP Primers for CAND1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CAND1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14   Ensembl cytogenetic band:  12q14.3   HGNC cytogenetic band: 12q14

CAND1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAND1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P067663:  view genomic region     (about GC identifiers)

Start:
67,663,061 bp from pter      End:
67,713,731 bp from pter
Size:
50,671 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CAND1_HUMAN, Q86VP6 (See protein sequence)
Recommended Name: Cullin-associated NEDD8-dissociated protein 1  
Size: 1230 amino acids; 136376 Da
Subunit: Interacts with TBP (By similarity). Part of a complex that contains CUL1 and RBX1. Interacts with
unneddylated cullins: interacts with CUL1, CUL2, CUL3, CUL4A, CUL4B and CUL5. Does not bind neddylated CUL1.
Interaction with cullins is abolished in presence of COMMD1, which antagonizes with CAND1 for interacting with
cullins
Miscellaneous: A model has been proposed to explain the mechanisms of cullin-RING E3 ubiquitin ligase complexes
assembly. According to this hypothesis, cullin-RING E3 ubiquitin ligase complexes exist in a 'stable' active
state when saturated with substrate, occluding access to deneddylation by the COP9 signalosome (CSN) complex. The
neddylation-conjugated cullin-RING E3 ubiquitin ligase complexes mediate ubiquitination of substrates and can
recruit downstream factors involved in substrate degradation. Depletion of the substrate promotes the ability of
CSN to bind the cullin-RING E3 ubiquitin ligase complex and mediate deneddylation. In this 'intermediate'
deneddylated state, the complex can bind CAND1 and enter the 'exchange' state, resulting in high increase in
dissociation rate of the substrate-recognition subunit. The resulting CAND1-cullin-RING complex rapidly assembles
with another available substrate-recognition subunit to form an unstable ternary intermediate and yield a new
cullin-RING E3 ubiquitin ligase complex. Subsequent neddylation of the cullin, which is stabilized by substrate,
completes the cycle (PubMed:23453757)
Sequence caution: Sequence=BAA74852.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB55090.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
2 PDB 3D structures from and Proteopedia for CAND1:
1U6G (3D)        4A0C (3D)    
Secondary accessions: B2RAU3 O94918 Q6PIY4 Q8NDJ4 Q96JZ9 Q96T19 Q9BTC4 Q9H0G2 Q9P0H7 Q9UF85
Alternative splicing: 3 isoforms:  Q86VP6-1   Q86VP6-2   Q86VP6-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CAND1: NX_Q86VP6

Explore proteomics data for CAND1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys14, Lys20, Lys51, Lys55, Lys255, Lys355, Lys373, Lys403, Lys630, Lys826,
                                 Lys957, Lys1037
  • Modification sites at PhosphoSitePlus

  • See CAND1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060918.2  
    ENSEMBL proteins: 
     ENSP00000442318   ENSP00000437594   ENSP00000445794   ENSP00000444089  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR011989 ARM-like
     IPR013932 TATA-bd_TIP120
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q86VP6

    ProtoNet protein and cluster: Q86VP6

    2 Blocks protein domains:
    IPB000357 HEAT repeat
    IPB013932 TATA-binding protein interacting (TIP20)


    UniProtKB/Swiss-Prot: CAND1_HUMAN, Q86VP6
    Similarity: Belongs to the CAND family
    Similarity: Contains 27 HEAT repeats


    CAND1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAND1_HUMAN, Q86VP6
    Function: Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the
    exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular
    repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled
    with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1,
    increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar
    role in other cullin-RING E3 ubiquitin ligase complexes
    Induction: Repressed by miR-148a

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI12504025
    GO:0017025TBP-class protein binding IEA--
         
    CAND1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CAND1:
     Increased cell death HMECs cel 

    Animal Models:
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    miRNA
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    hsa-mir-195-5p (MIRT044866), hsa-mir-1296-5p (MIRT036143), hsa-mir-425-5p (MIRT039318), hsa-mir-1301-3p (MIRT036016), hsa-mir-1 (MIRT001378), hsa-mir-186-5p (MIRT045132)

    Block miRNA regulation of human, mouse, rat CAND1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CAND1 (see all 21):
    hsa-miR-3164 hsa-miR-323-3p hsa-miR-607 hsa-miR-148b hsa-miR-500a hsa-miR-649 hsa-miR-3143 hsa-miR-148a
    SwitchGear 3'UTR luciferase reporter plasmidCAND1 3' UTR sequence
    Inhib. RNA
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    Sino Biological Human cDNA Clone for CAND1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CAND1_HUMAN, Q86VP6: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IDA12609982
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0031461cullin-RING ubiquitin ligase complex IDA15537541

    CAND1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CAND1 About    
    See pathways by source

    SuperPathContained pathways About
    1Protein Stability
    Protein Stability

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CAND1
        Protein Stability




    CAND1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CAND1
    Interactions:

        GeneGlobe Interaction Network for CAND1

    Selected Interacting proteins for CAND1 (Q86VP61, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 605)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CUL1Q136161, 2, 3EBI-456077,EBI-359390 MINT-4304052 MINT-7945693 I2D: score=7 
    CUL2Q136171, 3EBI-456077,EBI-456179 I2D: score=5 
    CUL4BQ136201, 3EBI-456077,EBI-456067 I2D: score=5 
    CUL3Q136181, 3EBI-456077,EBI-456129 I2D: score=4 
    CUL4AQ136191, 3EBI-456077,EBI-456106 I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010265SCF complex assembly IDA15537541
    GO:0016567protein ubiquitination IDA12609982
    GO:0030154cell differentiation IDA10581176
    GO:0043086negative regulation of catalytic activity IDA12609982
    GO:0045893positive regulation of transcription, DNA-templated ----

    CAND1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CAND1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CAND1 gene: 
    NM_018448.3  

    Unigene Cluster for CAND1:

    Cullin-associated and neddylation-dissociated 1
    Hs.546407  [show with all ESTs]
    Unigene Representative Sequence: NM_018448
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000545606(uc001stn.2 uc001sto.2) ENST00000541058 ENST00000539109
    ENST00000539434 ENST00000540525 ENST00000535146 ENST00000540319 ENST00000544619

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    Selected qRT-PCR Assays for microRNAs that regulate CAND1 (see all 21):
    hsa-miR-3164 hsa-miR-323-3p hsa-miR-607 hsa-miR-148b hsa-miR-500a hsa-miR-649 hsa-miR-3143 hsa-miR-148a
    SwitchGear 3'UTR luciferase reporter plasmidCAND1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CAND1
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      QuantiFast Probe-based Assays in human, mouse, rat CAND1

    Additional mRNA sequence: 

    AB020636.2 AF157326.1 AK000976.1 AK001791.1 AK027404.1 AK027783.1 AK074922.1 AK096010.1 
    AK129780.1 AK292456.1 AK314358.1 AL133560.1 AL136810.1 AL833880.2 BC004232.1 BC026220.2 
    BC050341.1 

    15 DOTS entries:

    DT.316271  DT.100826732  DT.100826735  DT.100826724  DT.121152839  DT.316269  DT.70100724  DT.430793 
    DT.95234856  DT.121152825  DT.121152844  DT.121152886  DT.91758056  DT.91794617  DT.99988370 

    Selected AceView cDNA sequences (see all 392):

    BM478760 N47219 AW503445 AA774790 AA491234 CB140355 BM917780 BQ001404 
    AA806410 W92280 AA514379 BM684111 AA179457 BU508402 AI128318 AA339535 
    AW503098 AW675511 BE779777 AA761434 AW851296 BM504793 BQ437801 BG678210 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CAND1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b
    SP1:              -           -           -     -                                                                       -     -                     
    SP2:                                                                                            -                                                   
    SP3:              -           -                                                                                                                     
    SP4:                                                                                                                                                
    SP5:              -                                                                                                                                 


    ECgene alternative splicing isoforms for CAND1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CAND1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTTACAAT
    CAND1 Expression
    About this image

    CAND1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CAND1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.546407
        Custom PCR Arrays for CAND1
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    QuantiFast Probe-based Assays in human, mouse, rat CAND1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAND1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CAND1 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cand11 , 5 cullin associated and neddylation disassociated 11, 5 89.32(n)1
    99.43(a)1
      10 (67.08 cM)5
    719021  NM_027994.11  NP_082270.11 
     1191992555 
    chicken
    (Gallus gallus)
    Aves CAND11 cullin-associated and neddylation-dissociated 1 86.18(n)
    98.67(a)
      417837  XM_416078.4  XP_416078.3 
    lizard
    (Anolis carolinensis)
    Reptilia CAND16
    Uncharacterized protein
    99(a)
    1 ↔ 1
    GL343256.1(877695-909781)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia CF783134.12   -- 83.8(n)    CF783134.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa93g072 Danio rerio mRNA similar to TBP-interacting protein more 75.46(n)    BC047184.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cand11 Cullin-associated and neddylation-dissociated 1 56.22(n)
    59.57(a)
      34403  NM_001273404.1  NP_001260333.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cand-11 cand-1 48.87(n)
    39.37(a)
      180125  NM_074843.5  NP_507244.1 
    soybean
    (Glycine max)
    eudicotyledons 467953392   -- 71.01(n)  
    rice
    (Oryza sativa)
    Liliopsida AK069128.12   -- 72.35(n)    AK069128.1 


    ENSEMBL Gene Tree for CAND1 (if available)
    TreeFam Gene Tree for CAND1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CAND1 gene
    CAND22  
    1 SIMAP similar gene for CAND1 using alignment to 3 protein entries:     CAND1_HUMAN (see all proteins):
    CAND2

    CAND1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CAND1 (see all 921)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs39707851,2
    C--67661205(-) acaca-/CACA/CACA
    CA
    /CACACACA
    NNNNN
    2 -- us2k1 cds11CSA 2
    rs788476181,2
    C--67661231(+) TGTGTG/TTTACA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1157641561,2
    F--67661383(+) TATTAC/TGTATA 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1909554941,2
    --67661436(+) CAGGCC/TGGAGT 1 -- us2k10--------
    rs111766641,2
    C--67661519(+) GAGTAG/ACTGTG 1 -- us2k14Minor allele frequency- A:0.35NA EA 244
    rs742357341,2
    C,F--67661696(+) TTACAT/CACATT 1 -- us2k12Minor allele frequency- C:0.09NA EA 240
    rs1828530641,2
    C--67661803(+) TATTGC/GCTGAC 1 -- us2k10--------
    rs1117928931,2
    F--67661805(+) TTGCCC/TGACTT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1437963131,2
    --67662168(+) CATCAA/GGGCCA 1 -- us2k10--------
    rs1866428191,2
    --67662219(+) ATCAGC/TAGGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CAND1 (67663061 - 67713731 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CAND1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv756CNV Loss18451855
    nsv525023CNV Loss19592680
    esv8315CNV Gain19470904
    esv259573OTHER Complex20981092
    esv259775OTHER Complex20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CAND1
    DNA2.0 Custom Variant and Variant Library Synthesis for CAND1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607727    OMIM disorders: --

    8 diseases for CAND1:    
    About MalaCards
    glomuvenous malformation    cystic fibrosis    alzheimer's disease    hiv-1
    prostatitis    prostate cancer    malaria    endotheliitis


    CAND1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CAND1

    Export disorders for CAND1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CAND1 gene, integrated from 10 sources (see all 90):
    (articles sorted by number of sources associating them with CAND1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1998)
    2. TIP120A associates with cullins and modulates ubiquitin ligase activity. (PubMed id 12609982)1, 2, 9 Min K.-W.... Yoon J.-B. (J. Biol. Chem. 2003)
    3. Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins. (PubMed id 23453757)1, 2 Pierce N.W....Deshaies R.J. (Cell 2013)
    4. COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding. (PubMed id 21778237)1, 2 Mao X....Burstein E. (J. Biol. Chem. 2011)
    5. Regulation of cullin RING E3 ubiquitin ligases by CAND1 in vivo. (PubMed id 21249194)1, 2 Chua Y.S.... Hagen T. (PLoS ONE 2011)
    6. miR-148a is an androgen-responsive microRNA that promotes LNCaP prostate cell growth by repressing its target CAND1 expression. (PubMed id 20820187)1, 2 Murata T.... Inoue S. (Prostate Cancer Prostatic Dis. 2010)
    7. Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease. (PubMed id 19668339)1, 4 Potkin S.G....Macciardi F. (PLoS ONE 2009)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases. (PubMed id 15537541)1, 2 Goldenberg S.J.... Zheng N. (Cell 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55832 HGNC: 30688 AceView: TIP120A Ensembl:ENSG00000111530 euGenes: HUgn55832
    ECgene: CAND1 H-InvDB: CAND1

    (According to HUGE)
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    HUGE: KIAA0829

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CAND1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CAND1 gene:
    Search GeneIP for patents involving CAND1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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