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Aliases for CAMTA2 Gene

Aliases for CAMTA2 Gene

  • Calmodulin Binding Transcription Activator 2 2 3 5
  • KIAA0909 4

External Ids for CAMTA2 Gene

Previous GeneCards Identifiers for CAMTA2 Gene

  • GC17M005290
  • GC17M004816
  • GC17M005071
  • GC17M004812
  • GC17M004871

Summaries for CAMTA2 Gene

Entrez Gene Summary for CAMTA2 Gene

  • The protein encoded by this gene is a member of the calmodulin-binding transcription activator protein family. Members of this family share a common domain structure that consists of a transcription activation domain, a DNA-binding domain, and a calmodulin-binding domain. The encoded protein may be a transcriptional coactivator of genes involved in cardiac growth. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2010]

GeneCards Summary for CAMTA2 Gene

CAMTA2 (Calmodulin Binding Transcription Activator 2) is a Protein Coding gene. Diseases associated with CAMTA2 include miller-dieker lissencephaly syndrome. GO annotations related to this gene include chromatin binding and histone deacetylase binding. An important paralog of this gene is CAMTA1.

UniProtKB/Swiss-Prot for CAMTA2 Gene

  • Transcription activator. May act as tumor suppressor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMTA2 Gene

Genomics for CAMTA2 Gene

Regulatory Elements for CAMTA2 Gene

Enhancers for CAMTA2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CAMTA2 on UCSC Golden Path with GeneCards custom track

Promoters for CAMTA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CAMTA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CAMTA2 Gene

Chromosome:
17
Start:
4,967,992 bp from pter
End:
4,987,673 bp from pter
Size:
19,682 bases
Orientation:
Minus strand

Genomic View for CAMTA2 Gene

Genes around CAMTA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAMTA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAMTA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMTA2 Gene

Proteins for CAMTA2 Gene

  • Protein details for CAMTA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94983-CMTA2_HUMAN
    Recommended name:
    Calmodulin-binding transcription activator 2
    Protein Accession:
    O94983
    Secondary Accessions:
    • B9EGL0
    • D3DTL5
    • E7EWU5
    • Q7Z6M8
    • Q8N3V0
    • Q8NDG4
    • Q96G17

    Protein attributes for CAMTA2 Gene

    Size:
    1202 amino acids
    Molecular mass:
    131530 Da
    Quaternary structure:
    • May interact with calmodulin.
    SequenceCaution:
    • Sequence=AAH16163.1; Type=Frameshift; Positions=865; Evidence={ECO:0000305}; Sequence=BAA74932.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CAMTA2 Gene

neXtProt entry for CAMTA2 Gene

Proteomics data for CAMTA2 Gene at MOPED

Post-translational modifications for CAMTA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CAMTA2 Gene

Domains & Families for CAMTA2 Gene

Protein Domains for CAMTA2 Gene

Graphical View of Domain Structure for InterPro Entry

O94983

UniProtKB/Swiss-Prot:

CMTA2_HUMAN :
  • Contains 1 CG-1 DNA-binding domain.
  • Belongs to the CAMTA family.
  • Contains 3 ANK repeats.
Domain:
  • Contains 1 CG-1 DNA-binding domain.
  • Contains 1 IPT/TIG domain.
  • Contains 2 IQ domains.
Family:
  • Belongs to the CAMTA family.
Similarity:
  • Contains 3 ANK repeats.
genes like me logo Genes that share domains with CAMTA2: view

No data available for Gene Families for CAMTA2 Gene

Function for CAMTA2 Gene

Molecular function for CAMTA2 Gene

UniProtKB/Swiss-Prot Function:
Transcription activator. May act as tumor suppressor.

Gene Ontology (GO) - Molecular Function for CAMTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IBA --
GO:0003677 DNA binding IEA --
GO:0008134 transcription factor binding IGI 16678093
GO:0042826 histone deacetylase binding IDA 16678093
GO:0043565 sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with CAMTA2: view
genes like me logo Genes that share phenotypes with CAMTA2: view

Animal Models for CAMTA2 Gene

MGI Knock Outs for CAMTA2:

Animal Model Products

miRNA for CAMTA2 Gene

miRTarBase miRNAs that target CAMTA2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAMTA2 Gene

Localization for CAMTA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMTA2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAMTA2 Gene COMPARTMENTS Subcellular localization image for CAMTA2 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
mitochondrion 2

No data available for Gene Ontology (GO) - Cellular Components for CAMTA2 Gene

Pathways & Interactions for CAMTA2 Gene

SuperPathways for CAMTA2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CAMTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IGI 16678093
genes like me logo Genes that share ontologies with CAMTA2: view

No data available for Pathways by source and SIGNOR curated interactions for CAMTA2 Gene

Drugs & Compounds for CAMTA2 Gene

No Compound Related Data Available

Transcripts for CAMTA2 Gene

Unigene Clusters for CAMTA2 Gene

Calmodulin binding transcription activator 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAMTA2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^
SP1: - - -
SP2: -
SP3:
SP4:
SP5: -
SP6:
SP7:

ExUns: 22a · 22b · 22c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for CAMTA2 Gene

GeneLoc Exon Structure for
CAMTA2
ECgene alternative splicing isoforms for
CAMTA2

Expression for CAMTA2 Gene

mRNA expression in normal human tissues for CAMTA2 Gene

Protein differential expression in normal tissues from HIPED for CAMTA2 Gene

This gene is overexpressed in Plasma (67.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CAMTA2 Gene



SOURCE GeneReport for Unigene cluster for CAMTA2 Gene Hs.632242

mRNA Expression by UniProt/SwissProt for CAMTA2 Gene

O94983-CMTA2_HUMAN
Tissue specificity: Detected in brain. Expressed at constant levels throughout the cell cycle in neuroblastoma cell lines.
genes like me logo Genes that share expression patterns with CAMTA2: view

Protein tissue co-expression partners for CAMTA2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CAMTA2 Gene

Orthologs for CAMTA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAMTA2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CAMTA2 35
  • 91.77 (n)
  • 95.73 (a)
CAMTA2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAMTA2 35
  • 89.49 (n)
  • 92.31 (a)
CAMTA2 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Camta2 35
  • 88.73 (n)
  • 92.51 (a)
Camta2 16
Camta2 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CAMTA2 35
  • 99.03 (n)
  • 99 (a)
CAMTA2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Camta2 35
  • 88.87 (n)
  • 92.67 (a)
oppossum
(Monodelphis domestica)
Mammalia CAMTA2 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 80 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1392 35
zebrafish
(Danio rerio)
Actinopterygii zgc56118 35
CAMTA2 36
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Camta 36
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea camt-1 36
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
Species with no ortholog for CAMTA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAMTA2 Gene

ENSEMBL:
Gene Tree for CAMTA2 (if available)
TreeFam:
Gene Tree for CAMTA2 (if available)

Paralogs for CAMTA2 Gene

Paralogs for CAMTA2 Gene

(1) SIMAP similar genes for CAMTA2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with CAMTA2: view

Variants for CAMTA2 Gene

Sequence variations from dbSNP and Humsavar for CAMTA2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs238234 - 4,980,523(+) GTGAG(A/C/G)GTGGG nc-transcript-variant, reference, missense
rs16942615 - 4,972,333(+) CTTGG(A/G)GTTGG nc-transcript-variant, reference, missense
rs171133 -- 4,975,630(+) CACTC(A/G)GGCTT intron-variant
rs238228 -- 4,975,665(+) GAGGC(A/G)AAACT intron-variant
rs238229 -- 4,973,825(+) TTGAG(A/G)TGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAMTA2 Gene

Variant ID Type Subtype PubMed ID
nsv833349 CNV Loss 17160897
nsv907619 CNV Loss 21882294
nsv907620 CNV Loss 21882294
nsv833350 CNV Loss 17160897

Variation tolerance for CAMTA2 Gene

Residual Variation Intolerance Score: 17.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.80; 66.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAMTA2 Gene

HapMap Linkage Disequilibrium report
CAMTA2
Human Gene Mutation Database (HGMD)
CAMTA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMTA2 Gene

Disorders for CAMTA2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CAMTA2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
miller-dieker lissencephaly syndrome
  • mds
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CAMTA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAMTA2
genes like me logo Genes that share disorders with CAMTA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAMTA2 Gene

Publications for CAMTA2 Gene

  1. A novel family of calmodulin-binding transcription activators in multicellular organisms. (PMID: 11925432) Bouche N. … Fromm H. (J. Biol. Chem. 2002) 2 3 4 67
  2. CAMTA in cardiac hypertrophy. (PMID: 16678087) Schwartz R.J. … Schneider M.D. (Cell 2006) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. CAMTAs: calmodulin-binding transcription activators from plants to human. (PMID: 17689537) Finkler A. … Fromm H. (FEBS Lett. 2007) 3

Products for CAMTA2 Gene

Sources for CAMTA2 Gene

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