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Aliases for CAMTA2 Gene

Aliases for CAMTA2 Gene

  • Calmodulin Binding Transcription Activator 2 2 3 5
  • KIAA0909 4

External Ids for CAMTA2 Gene

Previous GeneCards Identifiers for CAMTA2 Gene

  • GC17M005290
  • GC17M004816
  • GC17M005071
  • GC17M004812
  • GC17M004871

Summaries for CAMTA2 Gene

Entrez Gene Summary for CAMTA2 Gene

  • The protein encoded by this gene is a member of the calmodulin-binding transcription activator protein family. Members of this family share a common domain structure that consists of a transcription activation domain, a DNA-binding domain, and a calmodulin-binding domain. The encoded protein may be a transcriptional coactivator of genes involved in cardiac growth. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2010]

GeneCards Summary for CAMTA2 Gene

CAMTA2 (Calmodulin Binding Transcription Activator 2) is a Protein Coding gene. Diseases associated with CAMTA2 include Miller-Dieker Lissencephaly Syndrome and Neuroblastoma. GO annotations related to this gene include chromatin binding and histone deacetylase binding. An important paralog of this gene is CAMTA1.

UniProtKB/Swiss-Prot for CAMTA2 Gene

  • Transcription activator. May act as tumor suppressor.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMTA2 Gene

Genomics for CAMTA2 Gene

Regulatory Elements for CAMTA2 Gene

Enhancers for CAMTA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G004937 1.4 ENCODE dbSUPER 25.4 +42.7 42656 14.4 MLX CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC SPAG7 CHRNE CAMTA2 ENO3 USP6 RNF167 PLD2 SLC25A11
GH17G005047 1.2 FANTOM5 ENCODE 26.2 -59.9 -59890 0.8 HDAC1 PKNOX1 SREBF2 ARID4B ZNF335 ZNF366 SCRT2 ZNF207 PCBP1 CREM CAMTA2 ENO3 SPAG7 ZFP3 PFN1 KIF1C INCA1 USP6 SLC52A1 LOC105371502
GH17G005044 1.1 ENCODE 26.3 -57.6 -57581 2.3 HDGF PKNOX1 FOXA2 ARNT CREB3L1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 SPAG7 CAMTA2 ENO3 NUP88 ENSG00000234203 KIF1C INCA1 PFN1 ZFP3 ZNF232
GH17G004985 1.1 ENCODE 25.9 +0.1 84 3.7 HNRNPUL1 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B CAMTA2 CHRNE ZNF594 LOC100130950 ENSG00000262678
GH17G004919 1.1 Ensembl ENCODE 17.1 +67.4 67423 1.6 FOXA2 SAP130 TAF1 ARID4B ZMYM3 CEBPG ZNF384 YY1 TEAD3 ZFHX2 CHRNE CAMTA2 ENO3 RNF167 GP1BA
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CAMTA2 on UCSC Golden Path with GeneCards custom track

Promoters for CAMTA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CAMTA2 Gene

4,967,992 bp from pter
4,987,673 bp from pter
19,682 bases
Minus strand

Genomic View for CAMTA2 Gene

Genes around CAMTA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAMTA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAMTA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMTA2 Gene

Proteins for CAMTA2 Gene

  • Protein details for CAMTA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calmodulin-binding transcription activator 2
    Protein Accession:
    Secondary Accessions:
    • B9EGL0
    • D3DTL5
    • E7EWU5
    • Q7Z6M8
    • Q8N3V0
    • Q8NDG4
    • Q96G17

    Protein attributes for CAMTA2 Gene

    1202 amino acids
    Molecular mass:
    131530 Da
    Quaternary structure:
    • May interact with calmodulin.
    • Sequence=AAH16163.1; Type=Frameshift; Positions=865; Evidence={ECO:0000305}; Sequence=BAA74932.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CAMTA2 Gene

neXtProt entry for CAMTA2 Gene

Post-translational modifications for CAMTA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CAMTA2 Gene

Domains & Families for CAMTA2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CAMTA family.
  • Belongs to the CAMTA family.
genes like me logo Genes that share domains with CAMTA2: view

No data available for Gene Families for CAMTA2 Gene

Function for CAMTA2 Gene

Molecular function for CAMTA2 Gene

UniProtKB/Swiss-Prot Function:
Transcription activator. May act as tumor suppressor.

Gene Ontology (GO) - Molecular Function for CAMTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IBA --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IDA 16678093
GO:0005515 protein binding IPI 16678093
GO:0008134 transcription factor binding IGI 16678093
genes like me logo Genes that share ontologies with CAMTA2: view
genes like me logo Genes that share phenotypes with CAMTA2: view

Animal Models for CAMTA2 Gene

MGI Knock Outs for CAMTA2:

Animal Model Products

CRISPR Products

miRNA for CAMTA2 Gene

miRTarBase miRNAs that target CAMTA2

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAMTA2 Gene

Localization for CAMTA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMTA2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAMTA2 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
mitochondrion 2
cytosol 2

Gene Ontology (GO) - Cellular Components for CAMTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 16678093
genes like me logo Genes that share ontologies with CAMTA2: view

Pathways & Interactions for CAMTA2 Gene

SuperPathways for CAMTA2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CAMTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IDA 16678093
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0014898 cardiac muscle hypertrophy in response to stress IDA 16678093
genes like me logo Genes that share ontologies with CAMTA2: view

No data available for Pathways by source and SIGNOR curated interactions for CAMTA2 Gene

Drugs & Compounds for CAMTA2 Gene

No Compound Related Data Available

Transcripts for CAMTA2 Gene

Unigene Clusters for CAMTA2 Gene

Calmodulin binding transcription activator 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAMTA2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^
SP1: - - -
SP2: -
SP5: -

ExUns: 22a · 22b · 22c

Relevant External Links for CAMTA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CAMTA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAMTA2 Gene

Protein differential expression in normal tissues from HIPED for CAMTA2 Gene

This gene is overexpressed in Plasma (67.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CAMTA2 Gene

Protein tissue co-expression partners for CAMTA2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CAMTA2 Gene:


SOURCE GeneReport for Unigene cluster for CAMTA2 Gene:


mRNA Expression by UniProt/SwissProt for CAMTA2 Gene:

Tissue specificity: Detected in brain. Expressed at constant levels throughout the cell cycle in neuroblastoma cell lines.

Evidence on tissue expression from TISSUES for CAMTA2 Gene

  • Muscle(2)
  • Nervous system(4.8)
  • Eye(4.3)
genes like me logo Genes that share expression patterns with CAMTA2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAMTA2 Gene

Orthologs for CAMTA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAMTA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CAMTA2 34 35
  • 99.03 (n)
(Bos Taurus)
Mammalia CAMTA2 34 35
  • 91.77 (n)
(Canis familiaris)
Mammalia CAMTA2 34 35
  • 89.49 (n)
(Rattus norvegicus)
Mammalia Camta2 34
  • 88.87 (n)
(Mus musculus)
Mammalia Camta2 34 16 35
  • 88.73 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 80 (a)
(Monodelphis domestica)
Mammalia CAMTA2 35
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1392 34
(Danio rerio)
Actinopterygii CAMTA2 35
  • 39 (a)
zgc56118 34
fruit fly
(Drosophila melanogaster)
Insecta Camta 35
  • 14 (a)
(Caenorhabditis elegans)
Secernentea camt-1 35
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
Species where no ortholog for CAMTA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAMTA2 Gene

Gene Tree for CAMTA2 (if available)
Gene Tree for CAMTA2 (if available)

Paralogs for CAMTA2 Gene

Paralogs for CAMTA2 Gene

(1) SIMAP similar genes for CAMTA2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with CAMTA2: view

Variants for CAMTA2 Gene

Sequence variations from dbSNP and Humsavar for CAMTA2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000008477 -- 4,982,968(+) CAAAC(G/T)TTCTC intron-variant
rs1000064517 -- 4,975,692(+) GAGAG(A/T)GAGAA intron-variant
rs1000096604 -- 4,975,935(+) TGTAT(A/G)TGCCT intron-variant
rs1000191463 -- 4,986,832(+) ATAGA(A/C)TCTGG intron-variant, upstream-variant-2KB
rs1000248186 -- 4,970,591(+) CTGTA(A/C)CCTCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CAMTA2 Gene

Variant ID Type Subtype PubMed ID
dgv5431n54 CNV loss 21841781
nsv574273 CNV gain 21841781
nsv833349 CNV loss 17160897
nsv833350 CNV loss 17160897

Variation tolerance for CAMTA2 Gene

Residual Variation Intolerance Score: 17.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.80; 66.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAMTA2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMTA2 Gene

Disorders for CAMTA2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CAMTA2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
miller-dieker lissencephaly syndrome
  • mds
  • neuroblastoma 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CAMTA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CAMTA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAMTA2 Gene

Publications for CAMTA2 Gene

  1. A novel family of calmodulin-binding transcription activators in multicellular organisms. (PMID: 11925432) Bouche N. … Fromm H. (J. Biol. Chem. 2002) 2 3 4 64
  2. CAMTA in cardiac hypertrophy. (PMID: 16678087) Schwartz R.J. … Schneider M.D. (Cell 2006) 3 22 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for CAMTA2 Gene

Sources for CAMTA2 Gene

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