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Aliases for CAMTA2 Gene

Aliases for CAMTA2 Gene

  • Calmodulin Binding Transcription Activator 2 2 3
  • KIAA0909 4 6

External Ids for CAMTA2 Gene

Summaries for CAMTA2 Gene

Entrez Gene Summary for CAMTA2 Gene

  • The protein encoded by this gene is a member of the calmodulin-binding transcription activator protein family. Members of this family share a common domain structure that consists of a transcription activation domain, a DNA-binding domain, and a calmodulin-binding domain. The encoded protein may be a transcriptional coactivator of genes involved in cardiac growth. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2010]

GeneCards Summary for CAMTA2 Gene

CAMTA2 (Calmodulin Binding Transcription Activator 2) is a Protein Coding gene. Diseases associated with CAMTA2 include muscle hypertrophy. GO annotations related to this gene include chromatin binding and histone deacetylase binding. An important paralog of this gene is CAMTA1.

UniProtKB/Swiss-Prot for CAMTA2 Gene

  • Transcription activator. May act as tumor suppressor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMTA2 Gene

Genomics for CAMTA2 Gene

Genomic Location for CAMTA2 Gene

Start:
4,967,992 bp from pter
End:
4,987,673 bp from pter
Size:
19,682 bases
Orientation:
Minus strand

Genomic View for CAMTA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAMTA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMTA2 Gene

Regulatory Elements for CAMTA2 Gene

Proteins for CAMTA2 Gene

  • Protein details for CAMTA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94983-CMTA2_HUMAN
    Recommended name:
    Calmodulin-binding transcription activator 2
    Protein Accession:
    O94983
    Secondary Accessions:
    • B9EGL0
    • D3DTL5
    • E7EWU5
    • Q7Z6M8
    • Q8N3V0
    • Q8NDG4
    • Q96G17

    Protein attributes for CAMTA2 Gene

    Size:
    1202 amino acids
    Molecular mass:
    131530 Da
    Quaternary structure:
    • May interact with calmodulin.
    SequenceCaution:
    • Sequence=AAH16163.1; Type=Frameshift; Positions=865; Evidence={ECO:0000305}; Sequence=BAA74932.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CAMTA2 Gene

neXtProt entry for CAMTA2 Gene

Proteomics data for CAMTA2 Gene at MOPED

Post-translational modifications for CAMTA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CAMTA2 Gene

Domains for CAMTA2 Gene

Protein Domains for CAMTA2 Gene

UniProtKB/Swiss-Prot:

CMTA2_HUMAN
Domain:
  • Contains 1 CG-1 DNA-binding domain.:
    • O94983
  • Contains 1 IPT/TIG domain.:
    • O94983
  • Contains 2 IQ domains.:
    • O94983
Family:
  • Belongs to the CAMTA family.:
    • O94983
Similarity:
  • Contains 3 ANK repeats.:
    • O94983
genes like me logo Genes that share domains with CAMTA2: view

No data available for Gene Families for CAMTA2 Gene

Function for CAMTA2 Gene

Molecular function for CAMTA2 Gene

UniProtKB/Swiss-Prot Function: Transcription activator. May act as tumor suppressor.

Gene Ontology (GO) - Molecular Function for CAMTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IDA 16678093
GO:0005515 protein binding IPI 16678093
GO:0008134 transcription factor binding IGI 16678093
GO:0042826 histone deacetylase binding IDA 16678093
genes like me logo Genes that share ontologies with CAMTA2: view

Phenotypes for CAMTA2 Gene

MGI mutant phenotypes for CAMTA2:
inferred from 1 alleles
GenomeRNAi human phenotypes for CAMTA2:
genes like me logo Genes that share phenotypes with CAMTA2: view

Animal Models for CAMTA2 Gene

MGI Knock Outs for CAMTA2:

miRNA for CAMTA2 Gene

miRTarBase miRNAs that target CAMTA2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CAMTA2 Gene

Localization for CAMTA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMTA2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAMTA2 Gene COMPARTMENTS Subcellular localization image for CAMTA2 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CAMTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16678093
genes like me logo Genes that share ontologies with CAMTA2: view

Pathways for CAMTA2 Gene

SuperPathways for CAMTA2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CAMTA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IDA 16678093
GO:0014898 cardiac muscle hypertrophy in response to stress IDA 16678093
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IGI 16678093
genes like me logo Genes that share ontologies with CAMTA2: view

No data available for Pathways by source for CAMTA2 Gene

Transcripts for CAMTA2 Gene

Unigene Clusters for CAMTA2 Gene

Calmodulin binding transcription activator 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAMTA2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^
SP1: - - -
SP2: -
SP3:
SP4:
SP5: -
SP6:
SP7:

ExUns: 22a · 22b · 22c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for CAMTA2 Gene

GeneLoc Exon Structure for
CAMTA2
ECgene alternative splicing isoforms for
CAMTA2

Expression for CAMTA2 Gene

mRNA expression in normal human tissues for CAMTA2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CAMTA2 Gene

SOURCE GeneReport for Unigene cluster for CAMTA2 Gene Hs.632242

mRNA Expression by UniProt/SwissProt for CAMTA2 Gene

O94983-CMTA2_HUMAN
Tissue specificity: Detected in brain. Expressed at constant levels throughout the cell cycle in neuroblastoma cell lines.
genes like me logo Genes that share expressions with CAMTA2: view

Orthologs for CAMTA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAMTA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAMTA2 36
  • 99.03 (n)
  • 99 (a)
CAMTA2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CAMTA2 36
  • 91.77 (n)
  • 95.73 (a)
CAMTA2 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAMTA2 36
  • 89.49 (n)
  • 92.31 (a)
CAMTA2 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Camta2 36
  • 88.73 (n)
  • 92.51 (a)
Camta2 16
Camta2 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CAMTA2 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 80 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Camta2 36
  • 88.87 (n)
  • 92.67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1392 36
zebrafish
(Danio rerio)
Actinopterygii CAMTA2 37
  • 39 (a)
OneToOne
zgc56118 36
fruit fly
(Drosophila melanogaster)
Insecta Camta 37
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea camt-1 37
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 30 (a)
OneToMany
Species with no ortholog for CAMTA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAMTA2 Gene

ENSEMBL:
Gene Tree for CAMTA2 (if available)
TreeFam:
Gene Tree for CAMTA2 (if available)

Paralogs for CAMTA2 Gene

Paralogs for CAMTA2 Gene

Selected SIMAP similar genes for CAMTA2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with CAMTA2: view

Variants for CAMTA2 Gene

Sequence variations from dbSNP and Humsavar for CAMTA2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs171133 -- 4,975,630(+) CACTC(A/G)GGCTT intron-variant
rs238228 -- 4,975,665(+) GAGGC(A/G)AAACT intron-variant
rs238229 -- 4,973,825(+) TTGAG(A/G)TGGCC intron-variant
rs238230 -- 4,972,271(+) TCCTC(C/T)GGAGC reference, synonymous-codon
rs238231 -- 4,983,477(-) tgaaa(C/T)cctgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAMTA2 Gene

Variant ID Type Subtype PubMed ID
nsv833349 CNV Loss 17160897
nsv907619 CNV Loss 21882294
nsv907620 CNV Loss 21882294
nsv833350 CNV Loss 17160897

Relevant External Links for CAMTA2 Gene

HapMap Linkage Disequilibrium report
CAMTA2
Human Gene Mutation Database (HGMD)
CAMTA2

Disorders for CAMTA2 Gene

(1) MalaCards Diseases for CAMTA2 Gene

Search for CAMTA2 Gene in MalaCards »
genes like me logo Genes that share disorders with CAMTA2: view

No data available for UniProtKB/Swiss-Prot for CAMTA2 Gene

Publications for CAMTA2 Gene

  1. A novel family of calmodulin-binding transcription activators in multicellular organisms. (PMID: 11925432) Bouche N. … Fromm H. (J. Biol. Chem. 2002) 2 3 4
  2. CAMTA in cardiac hypertrophy. (PMID: 16678087) Schwartz R.J. … Schneider M.D. (Cell 2006) 3 23
  3. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for CAMTA2 Gene

Sources for CAMTA2 Gene

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