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Aliases for CAMSAP3 Gene

Aliases for CAMSAP3 Gene

  • Calmodulin Regulated Spectrin-Associated Protein Family, Member 3 2 3
  • KIAA1543 2 3 4 6
  • NEZHA 3 6
  • Calmodulin-Regulated Spectrin-Associated Protein 3 3
  • Protein Phosphatase 1, Regulatory Subunit 80 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 80 2
  • Protein Nezha 4
  • PPP1R80 3

External Ids for CAMSAP3 Gene

Previous Symbols for CAMSAP3 Gene

  • KIAA1543

Summaries for CAMSAP3 Gene

GeneCards Summary for CAMSAP3 Gene

CAMSAP3 (Calmodulin Regulated Spectrin-Associated Protein Family, Member 3) is a Protein Coding gene. Among its related pathways are Stabilization and expansion of the E-cadherin adherens junction. GO annotations related to this gene include microtubule minus-end binding. An important paralog of this gene is CAMSAP2.

UniProtKB/Swiss-Prot for CAMSAP3 Gene

  • Microtubule minus-end binding protein that acts as a regulator of non-centrosomal microtubule dynamics and organization. Specifically required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites. May regulate the nucleation and the polymerization of microtubules. Indirectly, through the microtubule cytoskeleton, may regulate the organization of cellular organelles including the Golgi and the early endosomes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMSAP3 Gene

Genomics for CAMSAP3 Gene

Genomic Location for CAMSAP3 Gene

Start:
7,595,888 bp from pter
End:
7,618,310 bp from pter
Size:
22,423 bases
Orientation:
Plus strand

Genomic View for CAMSAP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAMSAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMSAP3 Gene

No data available for Regulatory Elements for CAMSAP3 Gene

Proteins for CAMSAP3 Gene

  • Protein details for CAMSAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P1Y5-CAMP3_HUMAN
    Recommended name:
    Calmodulin-regulated spectrin-associated protein 3
    Protein Accession:
    Q9P1Y5
    Secondary Accessions:
    • Q8NDF1

    Protein attributes for CAMSAP3 Gene

    Size:
    1249 amino acids
    Molecular mass:
    134750 Da
    Quaternary structure:
    • Interacts with PLEKHA7. Interacts with CAMSAP2 (By similarity).
    Miscellaneous:
    • Nezha is a deity in Chinese mythology

    Alternative splice isoforms for CAMSAP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAMSAP3 Gene

Proteomics data for CAMSAP3 Gene at MOPED

Post-translational modifications for CAMSAP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAMSAP3 Gene

No data available for DME Specific Peptides for CAMSAP3 Gene

Domains for CAMSAP3 Gene

Protein Domains for CAMSAP3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P1Y5

UniProtKB/Swiss-Prot:

CAMP3_HUMAN
Domain:
  • The CKK domain binds microtubules.:
    • Q9P1Y5
  • Contains 1 CH (calponin-homology) domain.:
    • Q9P1Y5
  • Contains 1 CKK domain.:
    • Q9P1Y5
Family:
  • Belongs to the CAMSAP1 family.:
    • Q9P1Y5
genes like me logo Genes that share domains with CAMSAP3: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for CAMSAP3 Gene

Function for CAMSAP3 Gene

Molecular function for CAMSAP3 Gene

UniProtKB/Swiss-Prot Function: Microtubule minus-end binding protein that acts as a regulator of non-centrosomal microtubule dynamics and organization. Specifically required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites. May regulate the nucleation and the polymerization of microtubules. Indirectly, through the microtubule cytoskeleton, may regulate the organization of cellular organelles including the Golgi and the early endosomes.

Gene Ontology (GO) - Molecular Function for CAMSAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008017 microtubule binding --
GO:0051011 microtubule minus-end binding IDA 19041755
genes like me logo Genes that share ontologies with CAMSAP3: view

Phenotypes for CAMSAP3 Gene

GenomeRNAi human phenotypes for CAMSAP3:
genes like me logo Genes that share phenotypes with CAMSAP3: view

miRNA for CAMSAP3 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CAMSAP3 Gene

Localization for CAMSAP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMSAP3 Gene

Cell junction, adherens junction. Cytoplasm. Cytoplasm, cytoskeleton. Note=Scattered in the cytoplasm, associated with the minus-end of microtubules and also detected at the centrosomes. Localizes along zonula adherens only at mature cell-cell contacts.

Gene Ontology (GO) - Cellular Components for CAMSAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19041755
GO:0005813 colocalizes_with centrosome IDA 23169647
GO:0005915 zonula adherens IDA 19041755
GO:0036449 microtubule minus-end IEA --
genes like me logo Genes that share ontologies with CAMSAP3: view

No data available for Subcellular locations from COMPARTMENTS for CAMSAP3 Gene

Pathways for CAMSAP3 Gene

genes like me logo Genes that share pathways with CAMSAP3: view

Pathways by source for CAMSAP3 Gene

Gene Ontology (GO) - Biological Process for CAMSAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IMP 23169647
GO:0010923 negative regulation of phosphatase activity IDA 19389623
GO:0033043 regulation of organelle organization IMP 23169647
GO:0034453 microtubule anchoring IMP 19041755
GO:0045218 zonula adherens maintenance IMP 19041755
genes like me logo Genes that share ontologies with CAMSAP3: view

Transcripts for CAMSAP3 Gene

Unigene Clusters for CAMSAP3 Gene

Calmodulin regulated spectrin-associated protein family, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAMSAP3 Gene

No ASD Table

Relevant External Links for CAMSAP3 Gene

GeneLoc Exon Structure for
CAMSAP3
ECgene alternative splicing isoforms for
CAMSAP3

Expression for CAMSAP3 Gene

mRNA expression in normal human tissues for CAMSAP3 Gene

mRNA differential expression in normal tissues according to GTEx for CAMSAP3 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (6.6) and Skin - Not Sun Exposed (Suprapubic) (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAMSAP3 Gene

SOURCE GeneReport for Unigene cluster for CAMSAP3 Gene Hs.17686

genes like me logo Genes that share expressions with CAMSAP3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CAMSAP3 Gene

Orthologs for CAMSAP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAMSAP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAMSAP3 35
  • 95.07 (n)
  • 94.17 (a)
CAMSAP3 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CAMSAP3 35
  • 87.2 (n)
  • 91.25 (a)
CAMSAP3 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAMSAP3 35
  • 87.14 (n)
  • 91.2 (a)
CAMSAP3 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Camsap3 35
  • 82.82 (n)
  • 89.87 (a)
Camsap3 16
Camsap3 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CAMSAP3 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAMSAP3 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Camsap3 35
  • 83.65 (n)
  • 90.81 (a)
lizard
(Anolis carolinensis)
Reptilia CAMSAP3 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia camsap3 35
  • 58.98 (n)
  • 59.21 (a)
Str.313 35
zebrafish
(Danio rerio)
Actinopterygii camsap3 35
  • 55.59 (n)
  • 53.77 (a)
SI:DKEY-209E8.1 36
  • 43 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Patronin 36
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ptrn-1 36
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1969 36
  • 20 (a)
OneToMany
Species with no ortholog for CAMSAP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAMSAP3 Gene

ENSEMBL:
Gene Tree for CAMSAP3 (if available)
TreeFam:
Gene Tree for CAMSAP3 (if available)

Paralogs for CAMSAP3 Gene

Paralogs for CAMSAP3 Gene

genes like me logo Genes that share paralogs with CAMSAP3: view

Variants for CAMSAP3 Gene

Sequence variations from dbSNP and Humsavar for CAMSAP3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs747569 -- 7,611,031(+) TGTCT(C/G)CCCCC intron-variant
rs794088 -- 7,613,241(+) CAAAC(C/T)CACTA intron-variant
rs1155715 -- 7,598,431(-) AACAC(C/T)GTCCG intron-variant
rs1155716 -- 7,598,344(-) CCACC(A/G)CCACC intron-variant
rs1644755 -- 7,614,845(+) GAAGC(C/T)TTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAMSAP3 Gene

Variant ID Type Subtype PubMed ID
esv2751809 CNV Gain 17911159
nsv833730 CNV Loss 17160897
dgv3712n71 CNV Loss 21882294
nsv910970 CNV Loss 21882294
nsv833731 CNV Loss 17160897
nsv910979 CNV Loss 21882294
esv2656803 CNV Deletion 23128226
esv2673205 CNV Deletion 23128226
esv993190 CNV Deletion 20482838

Relevant External Links for CAMSAP3 Gene

HapMap Linkage Disequilibrium report
CAMSAP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMSAP3 Gene

Disorders for CAMSAP3 Gene

No disorders were found for CAMSAP3 Gene.

No data available for UniProtKB/Swiss-Prot for CAMSAP3 Gene

Publications for CAMSAP3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts. (PMID: 19041755) Meng W. … Takeichi M. (Cell 2008) 2 3 4
  3. The CKK domain (DUF1781) binds microtubules and defines the CAMSAP/ssp4 family of animal proteins. (PMID: 19508979) Baines A.J. … Phillips G.W. (Mol. Biol. Evol. 2009) 2 3
  4. A physical and transcript map of the MCOLN1 gene region on human chromosome 19p13.3-p13.2. (PMID: 11318610) Acierno J.S. Jr. … Slaugenhaupt S.A. (Genomics 2001) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CAMSAP3 Gene

  • antibodies-online peptides for CAMSAP3
  • antibodies-online antibodies for CAMSAP3
  • antibodies-online kits for CAMSAP3

Sources for CAMSAP3 Gene

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