Aliases for CAMSAP3 Gene
Aliases for CAMSAP3 Gene
External Ids for CAMSAP3 Gene
- HGNC: 29307
- Entrez Gene: 57662
- Ensembl: ENSG00000076826
- OMIM: 612685
- UniProtKB: Q9P1Y5
Previous HGNC Symbols for CAMSAP3 Gene
- KIAA1543
Previous GeneCards Identifiers for CAMSAP3 Gene
- GC19P007661
Summaries for CAMSAP3 Gene
GeneCards Summary for CAMSAP3 Gene
CAMSAP3 (Calmodulin Regulated Spectrin Associated Protein Family Member 3) is a Protein Coding gene. Among its related pathways are Stabilization and expansion of the E-cadherin adherens junction. GO annotations related to this gene include microtubule binding and microtubule minus-end binding. An important paralog of this gene is CAMSAP2.
UniProtKB/Swiss-Prot for CAMSAP3 Gene
-
Microtubule minus-end binding protein that acts as a regulator of non-centrosomal microtubule dynamics and organization. Specifically required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites. May regulate the nucleation and the polymerization of microtubules. Indirectly, through the microtubule cytoskeleton, may regulate the organization of cellular organelles including the Golgi and the early endosomes.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMSAP3 Gene
Genomics for CAMSAP3 Gene
Regulatory Elements for CAMSAP3 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH19G007595 | 1.1 | ENCODE dbSUPER | 13.1 | +0.3 | 278 | 1.8 | ZSCAN4 ARID4B DMAP1 GLIS2 SCRT2 PCBP1 RELB THAP11 SP3 SP5 | XAB2 ELAVL1 HNRNPM CAMSAP3 ZNF414 PCP2 MIR6792 |
| GH19G007188 | 1.2 | Ensembl ENCODE dbSUPER | 10 | -406.9 | -406870 | 1.6 | CTCF SOX13 KLF1 CEBPG ZBTB40 ZNF121 ZFHX2 GATA2 FOS EGR2 | ARHGEF18 PEX11G TEX45 CAMSAP3 RETN GC19P007214 GC19P007151 |
| GH19G007714 | 1.1 | Ensembl ENCODE dbSUPER | 10.9 | +118.9 | 118905 | 1.3 | PKNOX1 DPF2 MNT MBD2 CTBP1 GATA3 ZNF544 CREB1 | CD209 TRAPPC5 MCEMP1 RPL21P129 CAMSAP3 ZNF414 CLEC4G FCER2 XAB2 LOC105372262 |
| GH19G007618 | 0.9 | dbSUPER | 13 | +20.9 | 20854 | 0.5 | KLF17 RAD21 RARA GLIS2 ZNF207 RELB PCBP1 CREM THAP11 ZNF263 | CAMSAP3 CLEC4G MIR6792 |
| GH19G007616 | 0.9 | dbSUPER | 13 | +20.7 | 20712 | 0.7 | ARID4B ZNF48 GLIS2 ZNF207 ZNF263 TBX21 SMARCA4 MXD3 NBN CTCF | XAB2 PET100 CAMSAP3 CLEC4G MIR6792 |
Regulatory Element Products
Genomic Location for CAMSAP3 Gene
- Chromosome:
- 19
- Start:
- 7,595,902 bp from pter
- End:
- 7,618,310 bp from pter
- Size:
- 22,409 bases
- Orientation:
- Plus strand
Genomic View for CAMSAP3 Gene
- Cytogenetic band:
-
- 19p13.2 by Ensembl
- 19p13.2 by Entrez Gene
- 19p13.2 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CAMSAP3 Gene
Proteins for CAMSAP3 Gene
-
Protein details for CAMSAP3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9P1Y5-CAMP3_HUMAN
- Recommended name:
- Calmodulin-regulated spectrin-associated protein 3
- Protein Accession:
- Q9P1Y5
- Q8NDF1
Protein attributes for CAMSAP3 Gene
- Size:
- 1249 amino acids
- Molecular mass:
- 134750 Da
- Quaternary structure:
-
- Interacts with PLEKHA7. Interacts with CAMSAP2 (By similarity).
- Miscellaneous:
-
- Nezha is a deity in Chinese mythology.
Protein Expression for CAMSAP3 Gene
Post-translational modifications for CAMSAP3 Gene
Other Protein References for CAMSAP3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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- antibodies-online Antibodies for CAMSAP3: See all 18
- GeneTex CAMSAP3 antibody for CAMSAP3
Protein Products
-
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Assay Products
No data available for DME Specific Peptides for CAMSAP3 Gene
Domains & Families for CAMSAP3 Gene
Gene Families for CAMSAP3 Gene
Protein Domains for CAMSAP3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CAMSAP3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9P1Y5UniProtKB/Swiss-Prot:
CAMP3_HUMAN :- The CKK domain binds microtubules.
- Belongs to the CAMSAP1 family.
- Domain:
-
- The CKK domain binds microtubules.
- Family:
-
- Belongs to the CAMSAP1 family.
Function for CAMSAP3 Gene
Molecular function for CAMSAP3 Gene
- UniProtKB/Swiss-Prot Function:
- Microtubule minus-end binding protein that acts as a regulator of non-centrosomal microtubule dynamics and organization. Specifically required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites. May regulate the nucleation and the polymerization of microtubules. Indirectly, through the microtubule cytoskeleton, may regulate the organization of cellular organelles including the Golgi and the early endosomes.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005516 | calmodulin binding | IEA | -- |
| GO:0008017 | microtubule binding | IEA | -- |
| GO:0030507 | spectrin binding | IEA | -- |
| GO:0051011 | microtubule minus-end binding | IDA | 19041755 |
Phenotypes for CAMSAP3 Gene
- MGI mutant phenotypes for CAMSAP3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CAMSAP3:
Animal Models for CAMSAP3 Gene
- MGI Knock Outs for CAMSAP3:
-
- Camsap3 tm1a(EUCOMM)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
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-
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- Search ViGene Biosciences for CAMSAP3
CRISPR Products
-
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-
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miRNA for CAMSAP3 Gene
- miRTarBase miRNAs that target CAMSAP3
miRNA Products
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Inhibitory RNA Products
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CAMSAP3
-
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-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAMSAP3 Gene
Localization for CAMSAP3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CAMSAP3 Gene
- Cell junction, adherens junction. Cytoplasm. Cytoplasm, cytoskeleton. Note=Scattered in the cytoplasm, associated with the minus-end of microtubules and also detected at the centrosomes. Localizes along zonula adherens only at mature cell-cell contacts.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,IDA | 19041755 |
| GO:0005813 | colocalizes_with centrosome | IDA | 23169647 |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005874 | microtubule | IEA | -- |
| GO:0005912 | adherens junction | IEA | -- |
Pathways & Interactions for CAMSAP3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Stabilization and expansion of the E-cadherin adherens junction | ||
Pathways by source for CAMSAP3 Gene
1 BioSystems pathway for CAMSAP3 Gene
Interacting Proteins for CAMSAP3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000226 | microtubule cytoskeleton organization | IMP | 23169647 |
| GO:0010923 | negative regulation of phosphatase activity | IDA | 19389623 |
| GO:0031175 | neuron projection development | IEA | -- |
| GO:0033043 | regulation of organelle organization | IMP | 23169647 |
| GO:0034453 | microtubule anchoring | IMP | 19041755 |
No data available for SIGNOR curated interactions for CAMSAP3 Gene
Transcripts for CAMSAP3 Gene
mRNA/cDNA for CAMSAP3 Gene
- (5) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (128) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CAMSAP3 Gene
- Calmodulin regulated spectrin-associated protein family, member 3:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for CAMSAP3
-
Santa Cruz Biotechnology (SCBT) CRISPR for CAMSAP3
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miRNA Products
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Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CAMSAP3
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-
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Clone Products
- Addgene plasmids for CAMSAP3
- VectorBuilder custom plasmid, inducible vectors for CAMSAP3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CAMSAP3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CAMSAP3 Gene
mRNA differential expression in normal tissues according to GTEx for CAMSAP3 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CAMSAP3 Gene
NURSA nuclear receptor signaling pathways regulating expression of CAMSAP3 Gene:
CAMSAP3SOURCE GeneReport for Unigene cluster for CAMSAP3 Gene:
Hs.17686Evidence on tissue expression from TISSUES for CAMSAP3 Gene
- Nervous system(4.3)
- Liver(4.2)
Primer Products
-
OriGene qPCR primer pairs for CAMSAP3
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAMSAP3 Gene
Orthologs for CAMSAP3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CAMSAP3 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CAMSAP3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CAMSAP3 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Camsap3 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Camsap3 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CAMSAP3 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CAMSAP3 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CAMSAP3 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | camsap3 34 |
|
||
| Str.313 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | camsap3 34 |
|
||
| SI:DKEY-209E8.1 35 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | Patronin 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | ptrn-1 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.1969 35 |
|
OneToMany |
- Species where no ortholog for CAMSAP3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CAMSAP3 Gene
Variants for CAMSAP3 Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000011985 | -- | 7,601,494(+) | TTGTA(C/T)TTTTA | intron-variant | |
| rs1000059525 | -- | 7,601,884(+) | CGTGG(G/T)GAAAC | intron-variant | |
| rs1000184088 | -- | 7,613,700(+) | TGGGT(G/T)ATGGA | intron-variant | |
| rs1000223446 | -- | 7,610,188(+) | TGGCA(C/T)ACTCC | intron-variant | |
| rs1000239194 | -- | 7,604,528(+) | CTACC(C/T)CCCTC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1703n106 | CNV | deletion | 24896259 |
| esv2656803 | CNV | deletion | 23128226 |
| esv2673205 | CNV | deletion | 23128226 |
| esv2751809 | CNV | gain | 17911159 |
| esv993190 | CNV | deletion | 20482838 |
| nsv1060887 | CNV | gain | 25217958 |
| nsv1072316 | CNV | deletion | 25765185 |
| nsv1072855 | CNV | deletion | 25765185 |
| nsv833730 | CNV | loss | 17160897 |
| nsv833731 | CNV | loss | 17160897 |
| nsv953958 | CNV | deletion | 24416366 |
Relevant External Links for CAMSAP3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CAMSAP3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMSAP3 Gene
Disorders for CAMSAP3 Gene
Relevant External Links for CAMSAP3
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- CAMSAP3
No disorders were found for CAMSAP3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAMSAP3 Gene
Publications for CAMSAP3 Gene
- Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts. (PMID: 19041755) Meng W. … Takeichi M. (Cell 2008) 2 3 4 64
- Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
- Nezha/CAMSAP3 and CAMSAP2 cooperate in epithelial-specific organization of noncentrosomal microtubules. (PMID: 23169647) Tanaka N. … Takeichi M. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3 4 64
- The CKK domain (DUF1781) binds microtubules and defines the CAMSAP/ssp4 family of animal proteins. (PMID: 19508979) Baines A.J. … Phillips G.W. (Mol. Biol. Evol. 2009) 2 3 64
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64
Products for CAMSAP3 Gene
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- VectorBuilder custom plasmid, inducible vectors for CAMSAP3
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CAMSAP3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
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- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
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- (71) Sino Biological
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- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
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- (100) COMPARTMENTS
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