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Aliases for CAMSAP2 Gene

Aliases for CAMSAP2 Gene

  • Calmodulin Regulated Spectrin-Associated Protein Family, Member 2 2 3
  • Calmodulin-Regulated Spectrin-Associated Protein 1-Like Protein 1 3 4
  • CAMSAP1L1 3 4
  • KIAA1078 4 6
  • Calmodulin Regulated Spectrin-Associated Protein 1-Like 1 2
  • Calmodulin-Regulated Spectrin-Associated Protein 2 3
  • CAMSAP1L 6

External Ids for CAMSAP2 Gene

Previous HGNC Symbols for CAMSAP2 Gene

  • CAMSAP1L1

Previous GeneCards Identifiers for CAMSAP2 Gene

  • GC01P200709

Summaries for CAMSAP2 Gene

GeneCards Summary for CAMSAP2 Gene

CAMSAP2 (Calmodulin Regulated Spectrin-Associated Protein Family, Member 2) is a Protein Coding gene. GO annotations related to this gene include microtubule binding. An important paralog of this gene is CAMSAP3.

UniProtKB/Swiss-Prot for CAMSAP2 Gene

  • Microtubule minus-end binding protein that may regulate the organization of non-centrosomal microtubules. May regulate the nucleation and the polymerization of microtubules. Indirectly, through the microtubule cytoskeleton, may regulate the organization of cellular organelles including the Golgi and the early endosomes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMSAP2 Gene

Genomics for CAMSAP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CAMSAP2 Gene

Start:
200,739,558 bp from pter
End:
200,860,704 bp from pter
Size:
121,147 bases
Orientation:
Plus strand

Genomic View for CAMSAP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAMSAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMSAP2 Gene

No data available for Regulatory Elements for CAMSAP2 Gene

Proteins for CAMSAP2 Gene

  • Protein details for CAMSAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08AD1-CAMP2_HUMAN
    Recommended name:
    Calmodulin-regulated spectrin-associated protein 2
    Protein Accession:
    Q08AD1
    Secondary Accessions:
    • B1APG6
    • Q08AD2
    • Q6PGN8
    • Q96FB3
    • Q9UG20
    • Q9UPS4

    Protein attributes for CAMSAP2 Gene

    Size:
    1489 amino acids
    Molecular mass:
    168089 Da
    Quaternary structure:
    • Interacts with CAMSAP3.
    SequenceCaution:
    • Sequence=AAH56910.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CAMSAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAMSAP2 Gene

Proteomics data for CAMSAP2 Gene at MOPED

Post-translational modifications for CAMSAP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAMSAP2 Gene

No data available for DME Specific Peptides for CAMSAP2 Gene

Domains for CAMSAP2 Gene

Protein Domains for CAMSAP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q08AD1

UniProtKB/Swiss-Prot:

CAMP2_HUMAN :
  • Q08AD1
Domain:
  • The CKK domain binds microtubules.
  • Contains 1 CH (calponin-homology) domain.
  • Contains 1 CKK domain.
Family:
  • Belongs to the CAMSAP1 family.
genes like me logo Genes that share domains with CAMSAP2: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for CAMSAP2 Gene

Function for CAMSAP2 Gene

Molecular function for CAMSAP2 Gene

UniProtKB/Swiss-Prot Function: Microtubule minus-end binding protein that may regulate the organization of non-centrosomal microtubules. May regulate the nucleation and the polymerization of microtubules. Indirectly, through the microtubule cytoskeleton, may regulate the organization of cellular organelles including the Golgi and the early endosomes.

Gene Ontology (GO) - Molecular Function for CAMSAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20195357
GO:0008017 microtubule binding --
GO:0051011 microtubule minus-end binding IDA 23169647
genes like me logo Genes that share ontologies with CAMSAP2: view

Phenotypes for CAMSAP2 Gene

genes like me logo Genes that share phenotypes with CAMSAP2: view

Animal Model Products

CRISPR Products

miRNA for CAMSAP2 Gene

miRTarBase miRNAs that target CAMSAP2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAMSAP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CAMSAP2 Gene

Localization for CAMSAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMSAP2 Gene

Cytoplasm, cytoskeleton. Note=Associated with the minus-end of microtubules and also detected at the centrosomes.

Gene Ontology (GO) - Cellular Components for CAMSAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 colocalizes_with centrosome IDA 23169647
GO:0036449 microtubule minus-end IEA --
genes like me logo Genes that share ontologies with CAMSAP2: view

No data available for Subcellular locations from COMPARTMENTS for CAMSAP2 Gene

Pathways for CAMSAP2 Gene

SuperPathways for CAMSAP2 Gene

No Data Available

Interacting Proteins for CAMSAP2 Gene

Gene Ontology (GO) - Biological Process for CAMSAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IMP 23169647
GO:0033043 regulation of organelle organization IMP 23169647
genes like me logo Genes that share ontologies with CAMSAP2: view

No data available for Pathways by source for CAMSAP2 Gene

Transcripts for CAMSAP2 Gene

Unigene Clusters for CAMSAP2 Gene

Calmodulin regulated spectrin-associated protein family, member 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAMSAP2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CAMSAP2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAMSAP2 Gene

No ASD Table

Relevant External Links for CAMSAP2 Gene

GeneLoc Exon Structure for
CAMSAP2
ECgene alternative splicing isoforms for
CAMSAP2

Expression for CAMSAP2 Gene

mRNA expression in normal human tissues for CAMSAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAMSAP2 Gene

SOURCE GeneReport for Unigene cluster for CAMSAP2 Gene Hs.23585

genes like me logo Genes that share expressions with CAMSAP2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CAMSAP2 Gene

Orthologs for CAMSAP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAMSAP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAMSAP1L1 35
  • 99.68 (n)
  • 99.46 (a)
CAMSAP1L1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CAMSAP2 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAMSAP2 35
  • 91.58 (n)
  • 95.81 (a)
CAMSAP2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Camsap2 35
  • 87.11 (n)
  • 93.16 (a)
Camsap2 16
Camsap2 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CAMSAP2 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAMSAP2 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Camsap2 35
  • 87.55 (n)
  • 93.49 (a)
chicken
(Gallus gallus)
Aves CAMSAP2 35
  • 79.67 (n)
  • 84.92 (a)
CAMSAP2 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAMSAP2 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia camsap2 35
  • 68.28 (n)
  • 71.54 (a)
zebrafish
(Danio rerio)
Actinopterygii camsap2 35
  • 69.6 (n)
  • 75.88 (a)
camsap2 36
  • 59 (a)
OneToMany
CAMSAP2 (1 of 2) 36
  • 55 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Patronin 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ptrn-1 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1969 36
  • 28 (a)
OneToMany
Species with no ortholog for CAMSAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAMSAP2 Gene

ENSEMBL:
Gene Tree for CAMSAP2 (if available)
TreeFam:
Gene Tree for CAMSAP2 (if available)

Paralogs for CAMSAP2 Gene

Paralogs for CAMSAP2 Gene

Selected SIMAP similar genes for CAMSAP2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CAMSAP2: view

Variants for CAMSAP2 Gene

Sequence variations from dbSNP and Humsavar for CAMSAP2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs957148 -- 200,817,482(+) TATTG(G/T)AATTG intron-variant
rs972804 -- 200,750,269(-) ataaa(A/C)tccat intron-variant
rs1045983 -- 200,860,411(+) AAATT(C/T)TGCTA utr-variant-3-prime
rs1046024 -- 200,860,578(+) TGTCC(A/C)CTCTA utr-variant-3-prime
rs1389642 -- 200,815,089(+) GCATT(A/T)TGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAMSAP2 Gene

Variant ID Type Subtype PubMed ID
nsv873095 CNV Gain 21882294
nsv873096 CNV Gain 21882294
nsv826176 CNV Gain 20364138
nsv528910 CNV Loss 19592680
esv2721339 CNV Deletion 23290073
esv1463839 CNV Deletion 17803354
nsv518356 CNV Loss 19592680
nsv873097 CNV Loss 21882294
nsv873098 CNV Gain 21882294
esv33174 CNV Loss 17666407

Relevant External Links for CAMSAP2 Gene

HapMap Linkage Disequilibrium report
CAMSAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMSAP2 Gene

Disorders for CAMSAP2 Gene

UniProtKB/Swiss-Prot

CAMP2_HUMAN
  • Note=Defects in CAMSAP2 may be a cause of susceptibility to epilepsy in the Chinese population.

No disorders were found for CAMSAP2 Gene.

Publications for CAMSAP2 Gene

  1. Two-stage genome-wide association study identifies variants in CAMSAP1L1 as susceptibility loci for epilepsy in Chinese. (PMID: 22116939) Guo Y. … Kwan P. (Hum. Mol. Genet. 2012) 3 4
  2. Nezha/CAMSAP3 and CAMSAP2 cooperate in epithelial-specific organization of noncentrosomal microtubules. (PMID: 23169647) Tanaka N. … Takeichi M. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3 4
  3. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 3 4
  4. KIF14 is a candidate oncogene in the 1q minimal region of genomic gain in multiple cancers. (PMID: 15897902) Corson T.W. … Gallie B.L. (Oncogene 2005) 2 3
  5. The CKK domain (DUF1781) binds microtubules and defines the CAMSAP/ssp4 family of animal proteins. (PMID: 19508979) Baines A.J. … Phillips G.W. (Mol. Biol. Evol. 2009) 2 3

Products for CAMSAP2 Gene

Sources for CAMSAP2 Gene

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