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Aliases for CAMSAP2 Gene

Aliases for CAMSAP2 Gene

  • Calmodulin Regulated Spectrin Associated Protein Family Member 2 2 3 5
  • Calmodulin Regulated Spectrin-Associated Protein Family, Member 2 2 3
  • Calmodulin-Regulated Spectrin-Associated Protein 1-Like Protein 1 3 4
  • CAMSAP1L1 3 4
  • Calmodulin Regulated Spectrin-Associated Protein 1-Like 1 2
  • KIAA1078 4

External Ids for CAMSAP2 Gene

Previous HGNC Symbols for CAMSAP2 Gene

  • CAMSAP1L1

Previous GeneCards Identifiers for CAMSAP2 Gene

  • GC01P200709

Summaries for CAMSAP2 Gene

GeneCards Summary for CAMSAP2 Gene

CAMSAP2 (Calmodulin Regulated Spectrin Associated Protein Family Member 2) is a Protein Coding gene. GO annotations related to this gene include microtubule binding and microtubule minus-end binding. An important paralog of this gene is CAMSAP3.

UniProtKB/Swiss-Prot for CAMSAP2 Gene

  • Microtubule minus-end binding protein that may regulate the organization of non-centrosomal microtubules. May regulate the nucleation and the polymerization of microtubules. Indirectly, through the microtubule cytoskeleton, may regulate the organization of cellular organelles including the Golgi and the early endosomes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMSAP2 Gene

Genomics for CAMSAP2 Gene

Regulatory Elements for CAMSAP2 Gene

Enhancers for CAMSAP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CAMSAP2 on UCSC Golden Path with GeneCards custom track

Promoters for CAMSAP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CAMSAP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CAMSAP2 Gene

Chromosome:
1
Start:
200,739,558 bp from pter
End:
200,860,707 bp from pter
Size:
121,150 bases
Orientation:
Plus strand

Genomic View for CAMSAP2 Gene

Genes around CAMSAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAMSAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAMSAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMSAP2 Gene

Proteins for CAMSAP2 Gene

  • Protein details for CAMSAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08AD1-CAMP2_HUMAN
    Recommended name:
    Calmodulin-regulated spectrin-associated protein 2
    Protein Accession:
    Q08AD1
    Secondary Accessions:
    • B1APG6
    • Q08AD2
    • Q6PGN8
    • Q96FB3
    • Q9UG20
    • Q9UPS4

    Protein attributes for CAMSAP2 Gene

    Size:
    1489 amino acids
    Molecular mass:
    168089 Da
    Quaternary structure:
    • Interacts with CAMSAP3.
    SequenceCaution:
    • Sequence=AAH56910.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CAMSAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAMSAP2 Gene

Proteomics data for CAMSAP2 Gene at MOPED

Post-translational modifications for CAMSAP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAMSAP2 Gene

No data available for DME Specific Peptides for CAMSAP2 Gene

Domains & Families for CAMSAP2 Gene

Protein Domains for CAMSAP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q08AD1

UniProtKB/Swiss-Prot:

CAMP2_HUMAN :
  • The CKK domain binds microtubules.
  • Belongs to the CAMSAP1 family.
Domain:
  • The CKK domain binds microtubules.
  • Contains 1 CH (calponin-homology) domain.
  • Contains 1 CKK domain.
Family:
  • Belongs to the CAMSAP1 family.
genes like me logo Genes that share domains with CAMSAP2: view

No data available for Gene Families for CAMSAP2 Gene

Function for CAMSAP2 Gene

Molecular function for CAMSAP2 Gene

UniProtKB/Swiss-Prot Function:
Microtubule minus-end binding protein that may regulate the organization of non-centrosomal microtubules. May regulate the nucleation and the polymerization of microtubules. Indirectly, through the microtubule cytoskeleton, may regulate the organization of cellular organelles including the Golgi and the early endosomes.

Gene Ontology (GO) - Molecular Function for CAMSAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005516 calmodulin binding IEA --
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with CAMSAP2: view

Phenotypes for CAMSAP2 Gene

genes like me logo Genes that share phenotypes with CAMSAP2: view

Animal Model Products

miRNA for CAMSAP2 Gene

miRTarBase miRNAs that target CAMSAP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CAMSAP2 Gene

Localization for CAMSAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMSAP2 Gene

Cytoplasm, cytoskeleton. Note=Associated with the minus-end of microtubules and also detected at the centrosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAMSAP2 Gene COMPARTMENTS Subcellular localization image for CAMSAP2 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for CAMSAP2 Gene

Pathways & Interactions for CAMSAP2 Gene

SuperPathways for CAMSAP2 Gene

No Data Available

Interacting Proteins for CAMSAP2 Gene

Gene Ontology (GO) - Biological Process for CAMSAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033043 regulation of organelle organization IMP 23169647
genes like me logo Genes that share ontologies with CAMSAP2: view

No data available for Pathways by source and SIGNOR curated interactions for CAMSAP2 Gene

Drugs & Compounds for CAMSAP2 Gene

No Compound Related Data Available

Transcripts for CAMSAP2 Gene

Unigene Clusters for CAMSAP2 Gene

Calmodulin regulated spectrin-associated protein family, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAMSAP2 Gene

No ASD Table

Relevant External Links for CAMSAP2 Gene

GeneLoc Exon Structure for
CAMSAP2
ECgene alternative splicing isoforms for
CAMSAP2

Expression for CAMSAP2 Gene

mRNA expression in normal human tissues for CAMSAP2 Gene

Protein differential expression in normal tissues from HIPED for CAMSAP2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (30.5), Frontal cortex (7.7), Milk (7.5), and Placenta (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAMSAP2 Gene



SOURCE GeneReport for Unigene cluster for CAMSAP2 Gene Hs.23585

genes like me logo Genes that share expression patterns with CAMSAP2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CAMSAP2 Gene

Orthologs for CAMSAP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAMSAP2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CAMSAP2 35
  • 91.58 (n)
  • 95.81 (a)
CAMSAP2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Camsap2 35
  • 87.11 (n)
  • 93.16 (a)
Camsap2 16
Camsap2 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CAMSAP1L1 35
  • 99.68 (n)
  • 99.46 (a)
CAMSAP1L1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Camsap2 35
  • 87.55 (n)
  • 93.49 (a)
cow
(Bos Taurus)
Mammalia CAMSAP2 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CAMSAP2 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAMSAP2 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves CAMSAP2 35
  • 79.67 (n)
  • 84.92 (a)
CAMSAP2 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAMSAP2 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia camsap2 35
  • 68.28 (n)
  • 71.54 (a)
zebrafish
(Danio rerio)
Actinopterygii camsap2 35
  • 69.6 (n)
  • 75.88 (a)
camsap2 36
  • 59 (a)
OneToMany
CAMSAP2 (1 of 2) 36
  • 55 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Patronin 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ptrn-1 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1969 36
  • 28 (a)
OneToMany
Species with no ortholog for CAMSAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAMSAP2 Gene

ENSEMBL:
Gene Tree for CAMSAP2 (if available)
TreeFam:
Gene Tree for CAMSAP2 (if available)

Paralogs for CAMSAP2 Gene

Paralogs for CAMSAP2 Gene

(2) SIMAP similar genes for CAMSAP2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CAMSAP2: view

Variants for CAMSAP2 Gene

Sequence variations from dbSNP and Humsavar for CAMSAP2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_038399 A colorectal cancer sample
rs3753952 -, - 200,849,642(+) TCACC(C/T)ATCTC reference, missense
rs6674599 -, - 200,849,852(+) AGAAC(C/G)TCAGT reference, missense
rs972804 -- 200,750,269(-) ataaa(A/C)tccat intron-variant
rs1045983 -- 200,860,411(+) AAATT(C/T)TGCTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CAMSAP2 Gene

Variant ID Type Subtype PubMed ID
nsv873095 CNV Gain 21882294
nsv873096 CNV Gain 21882294
nsv826176 CNV Gain 20364138
nsv528910 CNV Loss 19592680
esv2721339 CNV Deletion 23290073
esv1463839 CNV Deletion 17803354
nsv518356 CNV Loss 19592680
nsv873097 CNV Loss 21882294
nsv873098 CNV Gain 21882294
esv33174 CNV Loss 17666407

Variation tolerance for CAMSAP2 Gene

Residual Variation Intolerance Score: 8.14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.98; 49.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAMSAP2 Gene

HapMap Linkage Disequilibrium report
CAMSAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMSAP2 Gene

Disorders for CAMSAP2 Gene

UniProtKB/Swiss-Prot

CAMP2_HUMAN
  • Note=Defects in CAMSAP2 may be a cause of susceptibility to epilepsy in the Chinese population. {ECO:0000305 PubMed:22116939}.

Relevant External Links for CAMSAP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAMSAP2

No disorders were found for CAMSAP2 Gene.

No data available for MalaCards and Genatlas for CAMSAP2 Gene

Publications for CAMSAP2 Gene

  1. Nezha/CAMSAP3 and CAMSAP2 cooperate in epithelial-specific organization of noncentrosomal microtubules. (PMID: 23169647) Tanaka N. … Takeichi M. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3 4 67
  2. The CKK domain (DUF1781) binds microtubules and defines the CAMSAP/ssp4 family of animal proteins. (PMID: 19508979) Baines A.J. … Phillips G.W. (Mol. Biol. Evol. 2009) 2 3
  3. KIF14 is a candidate oncogene in the 1q minimal region of genomic gain in multiple cancers. (PMID: 15897902) Corson T.W. … Gallie B.L. (Oncogene 2005) 2 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for CAMSAP2 Gene

Sources for CAMSAP2 Gene

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