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Aliases for CAMSAP1 Gene

Aliases for CAMSAP1 Gene

  • Calmodulin Regulated Spectrin-Associated Protein 1 2 3
  • Calmodulin-Regulated Spectrin-Associated Protein 1 3
  • BA100C15.1 (Novel Protein) 3
  • BA100C15.1 3
  • PRO2405 3

External Ids for CAMSAP1 Gene

Previous GeneCards Identifiers for CAMSAP1 Gene

  • GC09M134141
  • GC09M134139
  • GC09M135927
  • GC09M137841
  • GC09M138700
  • GC09M108162

Summaries for CAMSAP1 Gene

GeneCards Summary for CAMSAP1 Gene

CAMSAP1 (Calmodulin Regulated Spectrin-Associated Protein 1) is a Protein Coding gene. GO annotations related to this gene include microtubule binding. An important paralog of this gene is CAMSAP2.

UniProtKB/Swiss-Prot for CAMSAP1 Gene

  • Probable microtubule-binding protein that plays a role in the regulation of cell morphology and cytoskeletal organization. Through interaction with spectrin may regulate neurite outgrowth.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMSAP1 Gene

Genomics for CAMSAP1 Gene

Regulatory Elements for CAMSAP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CAMSAP1 Gene

Start:
135,808,487 bp from pter
End:
135,907,228 bp from pter
Size:
98,742 bases
Orientation:
Minus strand

Genomic View for CAMSAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAMSAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMSAP1 Gene

Proteins for CAMSAP1 Gene

  • Protein details for CAMSAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T5Y3-CAMP1_HUMAN
    Recommended name:
    Calmodulin-regulated spectrin-associated protein 1
    Protein Accession:
    Q5T5Y3
    Secondary Accessions:
    • A1L4L2
    • B2REB2
    • B2REB3
    • Q70W33
    • Q8NCY0
    • Q96E80
    • Q96FM3
    • Q9UFJ5

    Protein attributes for CAMSAP1 Gene

    Size:
    1602 amino acids
    Molecular mass:
    177972 Da
    Quaternary structure:
    • Interacts with spectrin via SPTBN1; the interaction is direct. Interacts with calmodulin; calcium-dependent it prevents interaction with spectrin.
    SequenceCaution:
    • Sequence=AAI30581.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CAMSAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAMSAP1 Gene

Proteomics data for CAMSAP1 Gene at MOPED

Post-translational modifications for CAMSAP1 Gene

  • Ubiquitination at Lys49 and Lys1341
  • Modification sites at PhosphoSitePlus

Other Protein References for CAMSAP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CAMSAP1 Gene

Domains for CAMSAP1 Gene

Protein Domains for CAMSAP1 Gene

Suggested Antigen Peptide Sequences for CAMSAP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q5T5Y3

UniProtKB/Swiss-Prot:

CAMP1_HUMAN :
  • Q5T5Y3
Domain:
  • The CKK domain binds microtubules.
  • Contains 1 CH (calponin-homology) domain.
  • Contains 1 CKK domain.
Family:
  • Belongs to the CAMSAP1 family.
genes like me logo Genes that share domains with CAMSAP1: view

No data available for Gene Families for CAMSAP1 Gene

Function for CAMSAP1 Gene

Molecular function for CAMSAP1 Gene

UniProtKB/Swiss-Prot Function: Probable microtubule-binding protein that plays a role in the regulation of cell morphology and cytoskeletal organization. Through interaction with spectrin may regulate neurite outgrowth.

Gene Ontology (GO) - Molecular Function for CAMSAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0005516 calmodulin binding ISS --
GO:0008017 microtubule binding IDA 19508979
GO:0030507 spectrin binding IDA 24117850
genes like me logo Genes that share ontologies with CAMSAP1: view

Animal Model Products

CRISPR Products

miRNA for CAMSAP1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAMSAP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CAMSAP1 Gene

Localization for CAMSAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMSAP1 Gene

Cytoplasm, cytoskeleton. Note=Associates with microtubules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAMSAP1 Gene COMPARTMENTS Subcellular localization image for CAMSAP1 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for CAMSAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005874 microtubule IDA 19508979
genes like me logo Genes that share ontologies with CAMSAP1: view

Pathways for CAMSAP1 Gene

SuperPathways for CAMSAP1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Prostate Cancer in human,mouse,rat

Interacting Proteins for CAMSAP1 Gene

Gene Ontology (GO) - Biological Process for CAMSAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IMP 21834987
GO:0022604 regulation of cell morphogenesis IMP 21834987
GO:0031175 neuron projection development IMP 19508979
genes like me logo Genes that share ontologies with CAMSAP1: view

No data available for Pathways by source for CAMSAP1 Gene

Transcripts for CAMSAP1 Gene

Unigene Clusters for CAMSAP1 Gene

Calmodulin regulated spectrin-associated protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAMSAP1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CAMSAP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAMSAP1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: -
SP2:
SP3:
SP4:

Relevant External Links for CAMSAP1 Gene

GeneLoc Exon Structure for
CAMSAP1
ECgene alternative splicing isoforms for
CAMSAP1

Expression for CAMSAP1 Gene

mRNA expression in normal human tissues for CAMSAP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAMSAP1 Gene

SOURCE GeneReport for Unigene cluster for CAMSAP1 Gene Hs.522493

genes like me logo Genes that share expressions with CAMSAP1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CAMSAP1 Gene

Orthologs for CAMSAP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CAMSAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAMSAP1 35
  • 99.48 (n)
  • 99.5 (a)
CAMSAP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CAMSAP1 35
  • 79.36 (n)
  • 81.53 (a)
CAMSAP1 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAMSAP1 35
  • 82.22 (n)
  • 84.98 (a)
CAMSAP1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Camsap1 35
  • 82.85 (n)
  • 86.5 (a)
Camsap1 16
Camsap1 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CAMSAP1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAMSAP1 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Camsap1 35
  • 82.69 (n)
  • 87.4 (a)
chicken
(Gallus gallus)
Aves CAMSAP1 35
  • 73.42 (n)
  • 78.56 (a)
CAMSAP1 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAMSAP1 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488075 35
  • 68.52 (n)
  • 68.89 (a)
Str.20205 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3811 35
zebrafish
(Danio rerio)
Actinopterygii camsap1a 36
  • 52 (a)
OneToMany
camsap1b 35
  • 62.64 (n)
  • 61.79 (a)
camsap1b 36
  • 56 (a)
OneToMany
Dr.26623 35
fruit fly
(Drosophila melanogaster)
Insecta Patronin 36
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ptrn-1 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1969 36
  • 28 (a)
OneToMany
Species with no ortholog for CAMSAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAMSAP1 Gene

ENSEMBL:
Gene Tree for CAMSAP1 (if available)
TreeFam:
Gene Tree for CAMSAP1 (if available)

Paralogs for CAMSAP1 Gene

Paralogs for CAMSAP1 Gene

Selected SIMAP similar genes for CAMSAP1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CAMSAP1 Gene

genes like me logo Genes that share paralogs with CAMSAP1: view

Variants for CAMSAP1 Gene

Sequence variations from dbSNP and Humsavar for CAMSAP1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs7838 -- 135,809,677(-) CACAC(A/G)TGGGC utr-variant-3-prime
rs12671 -- 135,808,672(-) TTTCT(A/G)CACGT utr-variant-3-prime
rs12961 -- 135,883,005(-) CCTGT(A/T)ATCAA synonymous-codon, reference, upstream-variant-2KB
rs730399 -- 135,816,321(-) TGCCC(C/T)GTGCT intron-variant
rs913342 -- 135,815,881(-) ACGGC(C/G)TTCGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAMSAP1 Gene

Variant ID Type Subtype PubMed ID
nsv831756 CNV Loss 17160897
nsv894274 CNV Loss 21882294
nsv894276 CNV Loss 21882294
esv1005577 CNV Loss 20482838
esv25183 CNV Loss 19812545
esv2739312 CNV Deletion 23290073
esv2739313 CNV Deletion 23290073
nsv831757 CNV Loss 17160897
dgv8372n71 CNV Loss 21882294
nsv825173 CNV Gain 20364138
nsv894278 CNV Loss 21882294
dgv8373n71 CNV Loss 21882294
esv24094 CNV Loss 19812545

Relevant External Links for CAMSAP1 Gene

HapMap Linkage Disequilibrium report
CAMSAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMSAP1 Gene

Disorders for CAMSAP1 Gene

Relevant External Links for CAMSAP1

Genetic Association Database (GAD)
CAMSAP1
genes like me logo Genes that share disorders with CAMSAP1: view

No data available for UniProtKB/Swiss-Prot for CAMSAP1 Gene

Publications for CAMSAP1 Gene

  1. The CKK domain (DUF1781) binds microtubules and defines the CAMSAP/ssp4 family of animal proteins. (PMID: 19508979) Baines A.J. … Phillips G.W. (Mol. Biol. Evol. 2009) 3 4 23
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PMID: 21834987) Bai S.W. … Ridley A.J. (BMC Biol. 2011) 3 4
  4. A conserved sequence in CAMSAP1 (calmodulin regulated spectrin- associated protein 1) links its interaction with spectrin and calmodulin to neurite outgrowth. (PMID: 24117850) King M.D. … Baines A.J. (J. Neurochem. 2014) 3 4
  5. MicroRNA-126 modulates the tumor microenvironment by targeting calmodulin-regulated spectrin-associated protein 1 (Camsap1). (PMID: 24603804) Sun X. … Gu H. (Int. J. Oncol. 2014) 3

Products for CAMSAP1 Gene

Sources for CAMSAP1 Gene

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