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CAMP Gene

protein-coding   GIFtS: 58
GCID: GC03P048264

Cathelicidin Antimicrobial Peptide

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cathelicidin Antimicrobial Peptide1 2     CRAMP2
FALL392 3 5     FALL-392
18 KDa Cationic Antimicrobial Protein2 3     LL372
CAP-182 3     hCAP-183
CAP182 3     

External Ids:    HGNC: 14721   Entrez Gene: 8202   Ensembl: ENSG000001640477   OMIM: 6004745   UniProtKB: P499133   

Export aliases for CAMP gene to outside databases

Previous GC identifers: GC03P048066 GC03P047547 GC03P048225 GC03P048240


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CAMP Gene:
This gene encodes a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal
signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is
produced by extracellular proteolysis from the C-terminus. The encoded protein has several functions in addition
to antimicrobial activity, including cell chemotaxis, immune mediator induction and inflammatory response
regulation. (provided by RefSeq, Aug 2011)

GeneCards Summary for CAMP Gene:
CAMP (cathelicidin antimicrobial peptide) is a protein-coding gene. Diseases associated with CAMP include rosacea, and eczema herpeticum.

UniProtKB/Swiss-Prot: CAMP_HUMAN, P49913
Function: Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity

Gene Wiki entry for CAMP (Cathelicidin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the CAMP gene promoter:
         E2F-3a   CREB   E2F   deltaCREB   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCAMP promoter sequence
   Search Chromatin IP Primers for CAMP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CAMP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.3

CAMP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAMP gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P048264:  view genomic region     (about GC identifiers)

Start:
48,264,837 bp from pter      End:
48,266,981 bp from pter
Size:
2,145 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CAMP_HUMAN, P49913 (See protein sequence)
Recommended Name: Cathelicidin antimicrobial peptide precursor  
Size: 170 amino acids; 19301 Da
Caution: PubMed:11238224 sequence was incorrectly assigned to originate from M.mulatta
6 PDB 3D structures from and Proteopedia for CAMP:
2FBS (3D)        2FBU (3D)        2FCG (3D)        2K6O (3D)        2LMF (3D)        4EYC (3D)    
Secondary accessions: Q71SN9

Explore the universe of human proteins at neXtProt for CAMP: NX_P49913

Explore proteomics data for CAMP at MOPED

Post-translational modifications: 

  • The N-terminus is blocked1
  • Modification sites at neXtProt

  • See CAMP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004336.3  
    ENSEMBL proteins: 
     ENSP00000296435   ENSP00000458149  
    Reactome Protein details: P49913

    CAMP Human Recombinant Protein Products:

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    Novus Biologicals CAMP Proteins
    Novus Biologicals CAMP Lysates
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    Cloud-Clone Corp. Proteins for CAMP

    CAMP Antibody Products:

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    Abcam antibodies for CAMP
    Cloud-Clone Corp. Antibodies for CAMP
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    LSBio Antibodies in human, mouse, rat for CAMP

    CAMP Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CAMP
    Cloud-Clone Corp. CLIAs for CAMP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    3 InterPro protein domains:
     IPR022746 Cathlecidin_C
     IPR001894 Cathelicidin
     IPR018216 Cathelicidin_CS

    Graphical View of Domain Structure for InterPro Entry P49913

    ProtoNet protein and cluster: P49913

    1 Blocks protein domain: IPB001894 Cathelicidin

    UniProtKB/Swiss-Prot: CAMP_HUMAN, P49913
    Similarity: Belongs to the cathelicidin family


    CAMP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAMP_HUMAN, P49913
    Function: Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity

         Genatlas biochemistry entry for CAMP:
    cathelicidin cationic antimicrobial peptide,cathelin family,expressed in the specific granules of neutrophils,also
    expressed in bone marrow and testis

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    CAMP for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CAMP:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Camp):
     cellular  hematopoietic system  immune system  mortality/aging  vision/eye 

    CAMP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CAMP: Camptm1Rlg Camptm1.1Jimw

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CAMP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CAMP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAMP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAMP

    miRNA
    Products:
        
    miRTarBase miRNAs that target CAMP:
    hsa-mir-124-3p (MIRT023085)

    Block miRNA regulation of human, mouse, rat CAMP using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CAMP
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CAMP
    Predesigned siRNA for gene silencing in human, mouse, rat CAMP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CAMP

    Clone
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    OriGene clones in human, mouse for CAMP (see all 6)
    OriGene ORF clones in mouse, rat for CAMP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CAMP (NM_004345)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAMP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMP

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CAMP
    Browse ESI BIO Cell Lines and PureStem Progenitors for CAMP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CAMP_HUMAN, P49913: Secreted

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space ----
    GO:0005618cell wall TAS--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    CAMP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CAMP About    
    See pathways by source

    SuperPathContained pathways About
    1Salivary secretion
    Salivary secretion0.34
    2Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    SREBP signalling0.31
    3Tuberculosis
    Tuberculosis
    4Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for CAMP
        SREBP signalling
    Integrated Pancreatic Cancer Pathway

    1 Reactome Pathway for CAMP
        Phagosomal maturation (early endosomal stage)


    2 Kegg Pathways  (Kegg details for CAMP):
        Salivary secretion
    Tuberculosis


    CAMP for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CAMP: 
              Innate & Adaptive Immune Responses in human mouse rat
              Antibacterial Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CAMP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for CAMP (P499131, 3 ENSP000002964354) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IGF1RP080691, 3, ENSP000002680354EBI-6378485,EBI-475981 I2D: score=2 STRING: ENSP00000268035
    CTSGP083113, ENSP000002163364I2D: score=1 STRING: ENSP00000216336
    ELANEP082463, ENSP000002636214I2D: score=1 STRING: ENSP00000263621
    PRTN3P241583, ENSP000002343474I2D: score=1 STRING: ENSP00000234347
    GAPDHP044063I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934positive regulation of protein phosphorylation ----
    GO:0006952defense response ----
    GO:0008284positive regulation of cell proliferation ----
    GO:0042742defense response to bacterium IEA--
    GO:0044130negative regulation of growth of symbiont in host ----

    CAMP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CAMP

    1 DrugBank Compound for CAMP    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Selenocysteine-- 4408-78-0target--17139284 17016423 10592235

    Selected Novoseek inferred chemical compound relationships for CAMP gene (see all 67)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hbd2 85.9 12 12819054 (4), 17943185 (2), 16926414 (1), 15886266 (1) (see all 6)
    pr 39 78.1 1 17343577 (1)
    forskolin 64.3 45 15381832 (2), 14701824 (2), 8908208 (2), 15985706 (2) (see all 30)
    ibmx 52.2 19 15689414 (1), 7508195 (1), 8078306 (1), 18983503 (1) (see all 10)
    vitamin d 49.8 30 19389235 (4), 19005165 (2), 19133797 (2), 15985530 (2) (see all 9)
    pge2 49.5 40 9024261 (3), 15833737 (2), 18923446 (2), 15626689 (2) (see all 21)
    1,25 dihydroxy vitamin d3 45.8 5 15985530 (2), 19948723 (1)
    25-hydroxyvitamin d 44.1 2 19389235 (1), 16957024 (1)
    lipoteichoic acid 40.8 2 12244186 (1), 16940084 (1)
    iloprost 39.5 9 8908208 (3), 14670842 (1), 7547677 (1), 18983503 (1)



    CAMP for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CAMP gene: 
    NM_004345.4  

    Unigene Cluster for CAMP:

    Cathelicidin antimicrobial peptide
    Hs.51120  [show with all ESTs]
    Unigene Representative Sequence: BU506539
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296435(uc003csj.2) ENST00000576243
    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CAMP
    Clone
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    GenScript: all cDNA clones in your preferred vector: CAMP (NM_004345)
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CAMP
      QuantiTect SYBR Green Assays in human, mouse, rat CAMP
      QuantiFast Probe-based Assays in human, mouse, rat CAMP

    Additional mRNA sequence: 

    AY162210.1 AY251531.1 BC055089.1 CR457083.1 CR541961.1 U19970.1 X89658.1 Z38026.1 

    1 DOTS entry:

    DT.210451 

    Selected AceView cDNA sequences (see all 45):

    NM_004345 BM712116 BX280365 BM670409 AW574631 AY162210 BF893650 AY251531 
    CR457083 BF893660 BF893640 U19970 BC055089 AA770349 X89658 CR541961 
    BF902396 BP370445 AJ706351 AJ706901 AJ706132 AJ706514 AW404163 BF893631 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CAMP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGACCCAAA
    CAMP Expression
    About this image


    CAMP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 8 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Bone Marrow CD133+ Cells   
             neutrophils   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Bone Marrow
             bone marrow   
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Granulosa Cells Primary Follicle
    CAMP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CAMP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.51120

    UniProtKB/Swiss-Prot: CAMP_HUMAN, P49913
    Tissue specificity: Expressed in bone marrow and testis and neutrophils

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CAMP: 
              Innate & Adaptive Immune Responses in human mouse rat
              Antibacterial Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CAMP
    OriGene qSTAR qPCR primer pairs in human, mouse for CAMP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CAMP
    QuantiTect SYBR Green Assays in human, mouse, rat CAMP
    QuantiFast Probe-based Assays in human, mouse, rat CAMP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CAMP gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Camp1 , 5 cathelicidin antimicrobial peptide1, 5 70.48(n)1
    54.82(a)1
      9 (59.80 cM)5
    127961  NM_009921.21  NP_034051.21 
     1098473755 
    lizard
    (Anolis carolinensis)
    Reptilia CAMP6
    cathelicidin antimicrobial peptide
    25(a)
    1 ↔ 1
    GL343332.1(1040726-1045940)


    ENSEMBL Gene Tree for CAMP (if available)
    TreeFam Gene Tree for CAMP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CAMP (see all 109)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1403039321,2
    --48263002(+) TTTATC/TTCTCC 1 -- us2k10--------
    rs1868337361,2
    --48263096(+) GAGGTA/CGAATC 1 -- us2k10--------
    rs1453425111,2
    --48263229(+) AAAGAG/TCAGGA 1 -- us2k10--------
    rs1130068661,2
    C--48263273(+) TGACAT/GTCTGG 1 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs1915941451,2
    --48263474(+) AGGTGA/GAGTCT 1 -- us2k10--------
    rs1837606431,2
    C--48263517(+) ATGGCA/GGCAGG 1 -- us2k10--------
    rs767211261,2
    C,F--48263656(+) GGGACG/ATTCAT 1 -- us2k12Minor allele frequency- A:0.17CSA WA 120
    rs779938281,2
    C,F--48263782(+) GTGACC/TCCACA 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1888797051,2
    --48263933(+) ACCAGA/GCTTGA 1 -- us2k10--------
    rs1932365631,2
    --48264021(+) AGAAGC/GGTAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CAMP (48264837 - 48266981 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CAMP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834682CNV Gain17160897

    Human Gene Mutation Database (HGMD): CAMP
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CAMP
    DNA2.0 Custom Variant and Variant Library Synthesis for CAMP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600474    OMIM disorders: --

    Selected diseases for CAMP (see all 58):    
    About MalaCards
    rosacea    eczema herpeticum    catecholaminergic polymorphic ventricular tachycardia    cellulitis
    cardiovascular disease risk factor    periodontal disease    severe congenital neutropenia    disseminated intravascular coagulation
    cholera    polycystic kidney disease    neutropenia    cystic fibrosis
    kidney disease    skin disease    vaccinia    shigellosis
    acne    sepsis    acute promyelocytic leukemia    periodontitis


    CAMP for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CAMP gene (see all 38)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    eczema vaccinatum 63.9 1 14734759 (1)
    skin infection 59.7 3 15728389 (1), 15587410 (1)
    psoriasis 54 30 12374875 (3), 16100459 (3), 19645825 (3), 15587410 (3) (see all 11)
    dermatitis atopic 52.7 12 12374875 (2), 16100459 (2), 19808939 (1), 18573153 (1) (see all 8)
    skin diseases 49.4 7 16034119 (2), 20190140 (1), 16100459 (1), 10225921 (1)
    bacterial infections 49.3 9 19605696 (1), 12454100 (1), 12819054 (1), 16751768 (1) (see all 9)
    cholera 45.7 12 17697117 (3), 15345481 (1), 15689414 (1), 11956020 (1) (see all 10)
    inflammation 44.2 30 16740661 (2), 19075071 (2), 16340000 (1), 19309368 (1) (see all 22)
    cystic fibrosis 44 5 7529238 (1), 11053013 (1), 15463886 (1), 9736536 (1) (see all 5)
    arpkd 32.6 1 16767405 (1)

    Human Genome Epidemiology (HuGE) Navigator: CAMP (166 documents)

    Export disorders for CAMP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CAMP gene, integrated from 10 sources (see all 472):
    (articles sorted by number of sources associating them with CAMP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein. (PubMed id 7890387)1, 2, 9 Larrick J.W.... Wright S.C. (Infect. Immun. 1995)
    2. Structures of human host defense cathelicidin LL-37 and its smallest antimicrobial peptide KR-12 in lipid micelles. (PubMed id 18818205)1, 2 Wang G. (J. Biol. Chem. 2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Rhesus monkey (Macaca mulatta) mucosal antimicrobial peptides are close homologues of human molecules. (PubMed id 11238224)1, 2 Bals R.... Wilson J.M. (Clin. Diagn. Lab. Immunol. 2001)
    5. The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytes. (PubMed id 8681941)1, 2 Gudmundsson G.H....Salcedo R. (Eur. J. Biochem. 1996)
    6. Structural, functional analysis and localization of the human CAP18 gene. (PubMed id 8946956)1, 2 Larrick J.W....Balint R.F. (FEBS Lett. 1996)
    7. hCAP-18, a cathelin/pro-bactenecin-like protein of human neutrophil specific granules. (PubMed id 7615076)1, 2 Cowland J.B.... Borregaard N. (FEBS Lett. 1995)
    8. Structure of the gene for porcine peptide antibiotic PR-39, a cathelin gene family member: comparative mapping of the locus for the human peptide antibiotic FALL-39. (PubMed id 7624374)1, 3 Gudmundsson G.H....Boman H.G. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    9. FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis. (PubMed id 7529412)1, 2 Agerberth B....Gudmundsson G.H. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    10. LL-37 complexation with glycosaminoglycans in cystic fibrosis lungs inhibits antimicrobial activity, which can be restored by hypertonic saline. (PubMed id 19542465)1, 9 Bergsson G....McElvaney N.G. (J. Immunol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
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    PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 820 HGNC: 1472 AceView: CAMP Ensembl:ENSG00000164047 euGenes: HUgn820
    ECgene: CAMP Kegg: 820 H-InvDB: CAMP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CAMP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CAMP gene:
    Search GeneIP for patents involving CAMP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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