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Aliases for CAMP Gene

Aliases for CAMP Gene

  • Cathelicidin Antimicrobial Peptide 2 3 5
  • 18 KDa Cationic Antimicrobial Protein 3 4
  • CAP-18 3 4
  • FALL39 3 4
  • CAP18 3 4
  • FALL-39 3
  • HCAP-18 4
  • CRAMP 3
  • HSD26 3
  • LL37 3

External Ids for CAMP Gene

Previous GeneCards Identifiers for CAMP Gene

  • GC03P048066
  • GC03P047547
  • GC03P048225
  • GC03P048240
  • GC03P048264

Summaries for CAMP Gene

Entrez Gene Summary for CAMP Gene

  • This gene encodes a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is produced by extracellular proteolysis from the C-terminus. In addition to its antibacterial, antifungal, and antiviral activities, the encoded protein functions in cell chemotaxis, immune mediator induction, and inflammatory response regulation. [provided by RefSeq, Sep 2014]

GeneCards Summary for CAMP Gene

CAMP (Cathelicidin Antimicrobial Peptide) is a Protein Coding gene. Diseases associated with CAMP include Mycobacterium Marinum and Guttate Psoriasis. Among its related pathways are Immune System and SREBP signalling.

UniProtKB/Swiss-Prot for CAMP Gene

  • Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity.

Gene Wiki entry for CAMP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMP Gene

Genomics for CAMP Gene

Regulatory Elements for CAMP Gene

Enhancers for CAMP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F048247 0.9 Ensembl ENCODE 11.2 +24.7 24695 2.1 ARID1B IKZF1 MLLT1 NFE2 ATF2 SPI1 CAMP NME6 CDC25A FBXW12 CCDC51 TMA7 ATRIP SPINK8 NDUFB1P1 RNU7-128P
GH03F048267 1.2 Ensembl ENCODE 11 +45.3 45335 3.2 PAF1 MTA2 MNT ZFHX2 POLR2A IKZF1 NBN FOS EGR2 ZNF589 WDR6 FBXW12 PLXNB1 CDC25A NME6 SPINK8 CAMP ENSG00000244380 ATRIP
GH03F048273 0.8 Ensembl ENCODE 10.5 +50.5 50510 0.3 CTCF ZNF654 TRIM22 REST RAD21 POLR2A ZBTB48 SMC3 NME6 ZNF589 PLXNB1 CCDC51 TMA7 ATRIP FBXW12 SPINK8 CAMP CDC25A
GH03F047370 0.9 Ensembl ENCODE 4.4 -852.2 -852247 1.8 CTCF ZNF740 REST MNT ZBTB7A RAD21 ZNF610 POLR2A SMC3 ZNF600 KIF9 KLHL18 CAMP PTPN23 ENSG00000280173
GH03F048226 1.1 Ensembl ENCODE 0.8 +3.6 3635 1.3 MTA2 MNT TBX21 ZFHX2 IKZF1 NBN KLF9 FOS SPI1 EGR2 ZNF589 CDC25A NME6 NDUFB1P1 RNU7-128P ATRIP CCDC51 TMA7 ENSG00000244380 NCKIPSD
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CAMP on UCSC Golden Path with GeneCards custom track

Genomic Location for CAMP Gene

48,223,347 bp from pter
48,225,491 bp from pter
2,145 bases
Plus strand

Genomic View for CAMP Gene

Genes around CAMP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAMP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAMP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMP Gene

Proteins for CAMP Gene

  • Protein details for CAMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cathelicidin antimicrobial peptide
    Protein Accession:
    Secondary Accessions:
    • Q71SN9

    Protein attributes for CAMP Gene

    170 amino acids
    Molecular mass:
    19301 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CAMP Gene

neXtProt entry for CAMP Gene

Post-translational modifications for CAMP Gene

Other Protein References for CAMP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CAMP (CAMP/LL37/FALL39)

No data available for DME Specific Peptides for CAMP Gene

Domains & Families for CAMP Gene

Gene Families for CAMP Gene

Protein Domains for CAMP Gene

Suggested Antigen Peptide Sequences for CAMP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cathelicidin family.
  • Belongs to the cathelicidin family.
genes like me logo Genes that share domains with CAMP: view

Function for CAMP Gene

Molecular function for CAMP Gene

GENATLAS Biochemistry:
cathelicidin cationic antimicrobial peptide,cathelin family,expressed in the specific granules of neutrophils,also expressed in bone marrow and testis
UniProtKB/Swiss-Prot Function:
Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity.
genes like me logo Genes that share phenotypes with CAMP: view

Animal Models for CAMP Gene

MGI Knock Outs for CAMP:

Animal Model Products

miRNA for CAMP Gene

miRTarBase miRNAs that target CAMP

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAMP Gene

Localization for CAMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMP Gene


Gene Ontology (GO) - Cellular Components for CAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA,IDA 12759353
GO:0005618 cell wall TAS --
GO:0005737 cytoplasm IEA --
GO:0042581 specific granule IEA,IDA 12759353
genes like me logo Genes that share ontologies with CAMP: view

No data available for Subcellular locations from COMPARTMENTS for CAMP Gene

Pathways & Interactions for CAMP Gene

genes like me logo Genes that share pathways with CAMP: view

Pathways by source for CAMP Gene

2 BioSystems pathways for CAMP Gene
2 Reactome pathways for CAMP Gene

Interacting Proteins for CAMP Gene

SIGNOR curated interactions for CAMP Gene


Gene Ontology (GO) - Biological Process for CAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002227 innate immune response in mucosa IDA 12860195
GO:0006952 defense response IEA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0019731 antibacterial humoral response IDA 12860195
GO:0042742 defense response to bacterium IEA,IMP 21115716
genes like me logo Genes that share ontologies with CAMP: view

Drugs & Compounds for CAMP Gene

(50) Drugs for CAMP Gene - From: DrugBank, ClinicalTrials, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mitoxantrone Approved, Investigational Pharma 266
Prednisone Approved, Vet_approved Pharma 1359
Selenocysteine Experimental Pharma Target 0
Analgesics Pharma 11287
Anti-Inflammatory Agents Pharma 10355

(34) Additional Compounds for CAMP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) ApexBio Compounds for CAMP Gene

Compound Action Cas Number
6-Bnz-cAMP sodium salt cAMP analog,PKA activator 1135306-29-4
8-Bromo-cAMP, sodium salt cAMP-analogue 76939-46-3
cAMPS-Rp, triethylammonium salt 151837-09-1
cAMPS-Sp, triethylammonium salt
Dibutyryl-cAMP, sodium salt 16980-89-5
genes like me logo Genes that share compounds with CAMP: view

Transcripts for CAMP Gene

mRNA/cDNA for CAMP Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(45) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CAMP Gene

Cathelicidin antimicrobial peptide:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAMP Gene

No ASD Table

Relevant External Links for CAMP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CAMP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CAMP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAMP Gene

This gene is overexpressed in Whole Blood (x45.6).

Protein differential expression in normal tissues from HIPED for CAMP Gene

This gene is overexpressed in Nasal epithelium (25.5), Neutrophil (12.7), and Blymphocyte (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CAMP Gene

Protein tissue co-expression partners for CAMP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CAMP Gene:


SOURCE GeneReport for Unigene cluster for CAMP Gene:


mRNA Expression by UniProt/SwissProt for CAMP Gene:

Tissue specificity: Expressed in bone marrow and testis and neutrophils.
genes like me logo Genes that share expression patterns with CAMP: view

Primer Products

Orthologs for CAMP Gene

This gene was present in the common ancestor of chordates.

Orthologs for CAMP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CAMP 34 35
  • 99.41 (n)
(Bos Taurus)
Mammalia CATHL5 34 35
  • 78.12 (n)
-- 35
  • 60 (a)
  • 59 (a)
-- 35
  • 58 (a)
  • 57 (a)
  • 56 (a)
CATHL1 35 35
  • 54 (a)
  • 49 (a)
-- 35
  • 46 (a)
  • 45 (a)
(Canis familiaris)
Mammalia CAMP 34 35
  • 76.39 (n)
(Rattus norvegicus)
Mammalia Camp 34
  • 72.62 (n)
(Mus musculus)
Mammalia Camp 34 16 35
  • 70.48 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 35 (a)
-- 35
  • 34 (a)
-- 35
  • 28 (a)
-- 35
  • 26 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 32 (a)
-- 35
  • 32 (a)
-- 35
  • 23 (a)
-- 35
  • 22 (a)
-- 35
  • 20 (a)
-- 35
  • 9 (a)
(Anolis carolinensis)
Reptilia CAMP 35
  • 25 (a)
Species where no ortholog for CAMP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CAMP Gene

Gene Tree for CAMP (if available)
Gene Tree for CAMP (if available)

Paralogs for CAMP Gene

No data available for Paralogs for CAMP Gene

Variants for CAMP Gene

Sequence variations from dbSNP and Humsavar for CAMP Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs111459851 -- 48,224,601(+) TTTCC(A/G)GCTGG splice-acceptor-variant
rs111669059 -- 48,225,770(+) CATTC(A/G)AGGGA downstream-variant-500B
rs111916000 -- 48,225,936(+) CTCTG(A/G)CATTG downstream-variant-500B
rs112037155 -- 48,225,536(+) ACTGA(C/G)CCCTT downstream-variant-500B
rs112174022 -- 48,222,788(+) AGTTC(-/T)TTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CAMP Gene

Variant ID Type Subtype PubMed ID
nsv834682 CNV gain 17160897

Variation tolerance for CAMP Gene

Residual Variation Intolerance Score: 76.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAMP Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMP Gene

Disorders for CAMP Gene

MalaCards: The human disease database

(5) MalaCards diseases for CAMP Gene - From: GeneCards

Disorder Aliases PubMed IDs
mycobacterium marinum
  • fish tank granuloma
guttate psoriasis
  • psoriasis guttate
coffin-lowry syndrome
  • mental retardation with osteocartilaginous abnormalities
  • acne rosacea
- elite association - COSMIC cancer census association via MalaCards
Search CAMP in MalaCards View complete list of genes associated with diseases

Relevant External Links for CAMP

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CAMP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAMP Gene

Publications for CAMP Gene

  1. Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein. (PMID: 7890387) Larrick J.W. … Wright S.C. (Infect. Immun. 1995) 3 4 22 64
  2. LL-37 promotes rapid sensing of CpG oligodeoxynucleotides by B lymphocytes and plasmacytoid dendritic cells. (PMID: 20042575) Hurtado P. … Peh C.A. (J. Immunol. 2010) 3 22 64
  3. Injury downregulates the expression of the human cathelicidin protein hCAP18/LL-37 in atopic dermatitis. (PMID: 19645825) Mallbris L. … StAYhle M. (Exp. Dermatol. 2010) 3 22 64
  4. Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells. (PMID: 20190140) Niyonsaba F. … Okumura K. (J. Immunol. 2010) 3 22 64
  5. Low plasma level of cathelicidin antimicrobial peptide (hCAP18) predicts increased infectious disease mortality in patients undergoing hemodialysis. (PMID: 19133797) Gombart A.F. … Thadhani R. (Clin. Infect. Dis. 2009) 3 22 64

Products for CAMP Gene

Sources for CAMP Gene

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