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Aliases for CAMLG Gene

Aliases for CAMLG Gene

  • Calcium Modulating Ligand 2 3
  • Calcium-Signal Modulating Cyclophilin Ligand 2 3
  • Calcium-Modulating Cyclophilin Ligand 2 3
  • Cyclophilin B-Binding Protein 2 3
  • CAML 3 4
  • Calcium Signal-Modulating Cyclophilin Ligand 3

External Ids for CAMLG Gene

Previous GeneCards Identifiers for CAMLG Gene

  • GC05P133724
  • GC05P134588
  • GC05P134106
  • GC05P134150
  • GC05P134102
  • GC05P134074
  • GC05P129260

Summaries for CAMLG Gene

Entrez Gene Summary for CAMLG Gene

  • The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAMLG Gene

CAMLG (Calcium Modulating Ligand) is a Protein Coding gene. Among its related pathways are RANK Signaling in Osteoclasts.

UniProtKB/Swiss-Prot for CAMLG Gene

  • Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B

Gene Wiki entry for CAMLG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMLG Gene

Genomics for CAMLG Gene

Regulatory Elements for CAMLG Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CAMLG Gene

134,738,480 bp from pter
134,752,160 bp from pter
13,681 bases
Plus strand

Genomic View for CAMLG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAMLG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMLG Gene

Proteins for CAMLG Gene

  • Protein details for CAMLG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcium signal-modulating cyclophilin ligand
    Protein Accession:
    Secondary Accessions:
    • A1L3Y3

    Protein attributes for CAMLG Gene

    296 amino acids
    Molecular mass:
    32953 Da
    Quaternary structure:
    • The N-terminal domain binds to TNFRSF13B/TACI. Interacts with human herpes virus 8/HHV-8 protein K7; this interaction modulates intracellular calcium concentration.

neXtProt entry for CAMLG Gene

Proteomics data for CAMLG Gene at MOPED

Post-translational modifications for CAMLG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAMLG Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CAMLG (CAMLG)

No data available for DME Specific Peptides for CAMLG Gene

Domains for CAMLG Gene

Protein Domains for CAMLG Gene

Suggested Antigen Peptide Sequences for CAMLG Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CAMLG: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CAMLG Gene

Function for CAMLG Gene

Molecular function for CAMLG Gene

GENATLAS Biochemistry:
calcium-modulating cyclophilin ligand,involved in the regulation of calcium signaling in T lymphocytes and other cells (signal transduction)
UniProtKB/Swiss-Prot Function:
Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B

Gene Ontology (GO) - Molecular Function for CAMLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15451437
GO:0050839 cell adhesion molecule binding IEA --
genes like me logo Genes that share ontologies with CAMLG: view
genes like me logo Genes that share phenotypes with CAMLG: view

Animal Models for CAMLG Gene

MGI Knock Outs for CAMLG:

Animal Model Products

CRISPR Products

miRNA for CAMLG Gene

miRTarBase miRNAs that target CAMLG

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CAMLG Gene

Localization for CAMLG Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMLG Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CAMLG Gene COMPARTMENTS Subcellular localization image for CAMLG gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CAMLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 12919676
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CAMLG: view

Pathways for CAMLG Gene

genes like me logo Genes that share pathways with CAMLG: view

Pathways by source for CAMLG Gene

1 GeneGo (Thomson Reuters) pathway for CAMLG Gene

Gene Ontology (GO) - Biological Process for CAMLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001881 receptor recycling IEA --
GO:0006952 defense response TAS 7522304
GO:0007165 signal transduction TAS 7522304
GO:0007173 epidermal growth factor receptor signaling pathway IEA --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with CAMLG: view

Drugs for CAMLG Gene

(1) Drugbank Compounds for CAMLG Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • Ciclosporin
59865-13-3 Target binder approved, investigational

(1) HMDB Compounds for CAMLG Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(2) Novoseek inferred chemical compound relationships for CAMLG Gene

Compound -log(P) Hits PubMed IDs
blys 87.3 4
calcium 32 12
genes like me logo Genes that share compounds with CAMLG: view

Transcripts for CAMLG Gene

mRNA/cDNA for CAMLG Gene

Unigene Clusters for CAMLG Gene

Calcium modulating ligand:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAMLG

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAMLG Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4
SP1: -
SP2: - - -
SP4: - - - -

Relevant External Links for CAMLG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CAMLG Gene

mRNA expression in normal human tissues for CAMLG Gene

Protein differential expression in normal tissues for CAMLG Gene

This gene is overexpressed in Bone (27.9) and Fetal Brain (7.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAMLG Gene

SOURCE GeneReport for Unigene cluster for CAMLG Gene Hs.529846

mRNA Expression by UniProt/SwissProt for CAMLG Gene

Tissue specificity: Ubiquitous. Highest levels in brain, testis and ovary
genes like me logo Genes that share expressions with CAMLG: view

Expression partners for CAMLG Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CAMLG Gene

Orthologs for CAMLG Gene

This gene was present in the common ancestor of chordates.

Orthologs for CAMLG Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CAMLG 35
  • 92.58 (n)
  • 93.84 (a)
  • 94 (a)
(Canis familiaris)
Mammalia CAMLG 35
  • 91.78 (n)
  • 93.92 (a)
  • 94 (a)
(Mus musculus)
Mammalia Caml 35
  • 83.45 (n)
  • 89.46 (a)
Caml 16
Caml 36
  • 89 (a)
(Pan troglodytes)
Mammalia CAMLG 35
  • 99.55 (n)
  • 99.66 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Camlg 35
  • 82.14 (n)
  • 87.03 (a)
(Monodelphis domestica)
Mammalia CAMLG 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia CAMLG 36
  • 73 (a)
(Gallus gallus)
Aves CAMLG 35
  • 74.76 (n)
  • 75.36 (a)
  • 73 (a)
(Anolis carolinensis)
Reptilia CAMLG 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia camlg 35
  • 65.91 (n)
  • 65.28 (a)
Str.3785 35
African clawed frog
(Xenopus laevis)
Amphibia MGC53900 35
(Danio rerio)
Actinopterygii camlg 35
  • 54.68 (n)
  • 56.61 (a)
camlg 36
  • 38 (a)
Species with no ortholog for CAMLG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAMLG Gene

Gene Tree for CAMLG (if available)
Gene Tree for CAMLG (if available)

Paralogs for CAMLG Gene

No data available for Paralogs for CAMLG Gene

Variants for CAMLG Gene

Sequence variations from dbSNP and Humsavar for CAMLG Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs185011 -- 134,744,703(+) CATTT(G/T)GTCTA intron-variant
rs246348 -- 134,752,442(+) gagtg(C/T)agtgg downstream-variant-500B
rs246350 -- 134,740,626(+) GTCTC(A/G)CTCTG intron-variant
rs1044794 -- 134,751,145(+) TGATA(G/T)GAAGA utr-variant-3-prime
rs6865617 -- 134,736,501(+) CACTT(A/C)TTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CAMLG Gene

Variant ID Type Subtype PubMed ID
nsv830493 CNV Loss 17160897

Relevant External Links for CAMLG Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMLG Gene

Disorders for CAMLG Gene

(1) University of Copenhagen DISEASES for CAMLG Gene

(2) Novoseek inferred disease relationships for CAMLG Gene

Disease -log(P) Hits PubMed IDs
necrosis 29.8 2
tumors 5.67 2

Relevant External Links for CAMLG

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CAMLG: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot and Genatlas for CAMLG Gene

Publications for CAMLG Gene

  1. The gene for calcium-modulating cyclophilin ligand (CAMLG) is located on human chromosome 5q23 and a syntenic region of mouse chromosome 13. (PMID: 8824814) Bram R.J. … Copeland N.G. (Genomics 1996) 2 3 23
  2. Calcium signalling in T cells stimulated by a cyclophilin B-binding protein. (PMID: 7522304) Bram R.J. … Crabtree G.R. (Nature 1994) 3 4 23
  3. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 48
  4. Calcium-modulating cyclophilin ligand desensitizes hormone-evoked calcium release. (PMID: 11006089) Tovey S.C. … Bram R.J. (Biochem. Biophys. Res. Commun. 2000) 3 23
  5. Co-localization of calcium-modulating cyclophilin ligand with intracellular calcium pools. (PMID: 9632697) Holloway M.P. … Bram R.J. (J. Biol. Chem. 1998) 3 23

Products for CAMLG Gene

  • Addgene plasmids for CAMLG

Sources for CAMLG Gene

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