CAMLG Gene
protein-coding GIFtS: 54
GCID: GC05P134074
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calcium modulating ligand
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Aliases
for CAMLG gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Calcium Modulating Ligand1 2 | | CAML1 2 3 | | Calcium Signal-Modulating Cyclophilin Ligand2 | | Calcium-Modulating Cyclophilin Ligand2 | | Calcium-Signal Modulating Cyclophilin Ligand2 | | Cyclophilin B-Binding Protein2 |
Export aliases for CAMLG gene to outside databasesPrevious GC identifers: GC05P133724 GC05P134588 GC05P134106 GC05P134150 GC05P134102 GC05P129260 |
Summaries
for CAMLG gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CAMLG:
The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normallyleads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signalingintermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding tocyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. Thisintegral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicatingcyclophilin B in calcium signaling, even in the absence of cyclosporin. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CAMLG_HUMAN, P49069Function: Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds tocyclophilin B
Gene Wiki entry for CAMLG
|
Genomic Views
for CAMLG gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CAMLG gene promoter:
MEF-2A AREB6 C/EBPbeta AML1a NCX/Ncx aMEF-2 Cdc5
Other transcription factors
Search SABiosciences Chromatin IP Primers for CAMLG
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAMLG |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q23 Ensembl cytogenetic band: 5q31.1 HGNC cytogenetic band: 5q23CAMLG Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P134074: view genomic region
(about GC identifiers)
Start:
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134,074,191 bp from pter |
End:
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134,087,847 bp from pter |
Size:
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13,657 bases |
Orientation:
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plus strand |
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Proteins
for CAMLG gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CAMLG_HUMAN, P49069 (See
protein sequence)Recommended Name: Calcium signal-modulating cyclophilin ligand Size: 296 amino acids; 32953 Da
Subunit: The N-terminal domain binds to TNFRSF13B/TACI
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: A1L3Y3Explore the universe of human proteins at neXtProt for CAMLG: NX_P49069
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P49069
CAMLG Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001736.1
ENSEMBL proteins: ENSP00000297156 ENSP00000427331
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
CAMLG for ontologies About GeneDecksing
CAMLG Antibody Products:
Assay Products for CAMLG: |
Protein
Domains /
Families
for CAMLG gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CAMLG for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P49069ProtoNet protein and cluster: P49069 |
Function
for CAMLG gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CAMLG_HUMAN, P49069Function: Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds tocyclophilin B Genatlas biochemistry entry for CAMLG:calcium-modulating cyclophilin ligand,involved in the regulation of calcium signaling in T lymphocytes and other cells(signal transduction)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAMLG
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMLG |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
CAMLG for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Camltm1Rjb for CAMLG
4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Caml):
CAMLG for phenotypes About GeneDecksing
|
Pathways & Interactions
for CAMLG gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | BAFF in B-Cell Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for CAMLG
1  GeneGo (Thomson Reuters) Pathway for CAMLG
CAMLG for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CAMLG
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/14 Interacting proteins for CAMLG (P490691, 3 ENSP000002971564) via UniProtKB, MINT, STRING, and/or I2D (see all 14)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
CAMLG for ontologies About GeneDecksing
|
Drugs & Compounds
for CAMLG gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CAMLG for compounds About GeneDecksing
 Browse Tocris compounds for CAMLG
1 HMDB Compound for CAMLG About this table
1 DrugBank Compound for CAMLG About this table
2 Novoseek chemical compound relationships for CAMLG gene About this table
Search CenterWatch for drugs/clinical trials and news about CAMLG
|
Transcripts
for CAMLG gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CAMLG gene: NM_001745.3 Unigene Cluster for CAMLG: Calcium modulating ligand Hs.529846 [show with all ESTs]Unigene Representative Sequence: NM_0017452 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000297156(uc003kzt.3 uc003kzu.3) ENST00000514518
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAMLG (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAMLG
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CAMLG (NM_001745) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CAMLG | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMLG |
Additional cDNA sequence: AF068179.1 AK093716.1 AK313156.1 BC063532.1 BC130325.1 U18242.1 10 DOTS entries: DT.40202552 DT.100781346 DT.120885372 DT.99929720 DT.120885368 DT.91744677 DT.100035013 DT.95189805 DT.401091 DT.92023857 24/200 AceView cDNA sequences (see all 200): BQ228443 AA719413 CR590907 BG285233 AA366860 AW007129 CB215757 CR596597 BU948574 BP369172 CR616724 BX458495 AW006849 BF513201 AW611860 BM459213 CR610994 BG331932 NM_001745 BC063532 CB140326 BP351497 BG655744 BM696198
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for CAMLG About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 |
|---|
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| SP1: | | | | | | | | | - | | | | | | |
| SP2: | | | | | - | | - | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | - | | - | | - | | | | |
| SP5: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CAMLG
|
Expression
for CAMLG gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CAMLG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CAMLG Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CAMLG
SOURCE GeneReport for Unigene cluster: Hs.529846
UniProtKB/Swiss-Prot: CAMLG_HUMAN, P49069Tissue specificity: Ubiquitous. Highest levels in brain, testis and ovary
SABiosciences Custom PCR Arrays for CAMLG
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CAMLG
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CAMLG | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAMLG | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAMLG | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMLG |
Orthologs
for CAMLG gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CAMLG gene from 5/12 species (see all 12) About this table
ENSEMBL Gene Tree for CAMLG (if available)
TreeFam Gene Tree for CAMLG (if available) |
Paralogs
for CAMLG gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CAMLG gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CAMLG (134074191 - 134087847 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CAMLG: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CAMLG |
|
Disorders
/ Diseases
for CAMLG gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CAMLG for disorders About GeneDecksing
OMIM gene information: 601118
OMIM disorders: --
14  diseases for CAMLG: About MalaCardscongenital diaphragmatic hernia common variable immunodeficiency polyhydramnios hernia
acute myeloid leukemia myeloid leukemia kaposi's sarcoma rheumatoid arthritis
sarcoma arthritis immunodeficiency leukemia
atherosclerosis myeloma
1 disease from the University of Copenhagen DISEASES database for CAMLG:Common variable immunodeficiency 2 Novoseek disease relationships for CAMLG gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| necrosis |
29.8 |
2 |
10920230 (1), 9311921 (1) |
| tumors |
5.67 |
2 |
10920230 (1), 9311921 (1) |
Human Genome Epidemiology (HuGE) Navigator: CAMLG (1 document)
Export disorders for CAMLG gene to outside databases
|
Publications
for CAMLG gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CAMLG gene, integrated from 9 sources (see all 50):
(articles sorted by number of sources associating them with CAMLG) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Calcium signalling in T cells stimulated by a cyclophilin B-binding protein. (PubMed id 7522304)1, 2, 9 Bram R.J. and Crabtree G.R. (1994)
- The gene for calcium-modulating cyclophilin ligand (CAMLG) is located on human chromosome 5q23 and a syntenic region of mouse chromosome 13. (PubMed id 8824814)1, 3, 9 Bram R.J....Copeland N.G. (1996)
- Calcium-modulating cyclophilin ligand desensitizes hormone-evoked calcium release. (PubMed id 11006089)1, 9 Tovey S.C....Bram R.J. (2000)
- Co-localization of calcium-modulating cyclophilin ligand with intracellular calcium pools. (PubMed id 9632697)1, 9 Holloway M.P. and Bram R.J. (1998)
- NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily. (PubMed id 9311921)1, 9 von Buelow G.-U. and Bram R.J. (1997)
- Dengue virus utilizes calcium modulating cyclophilin-b inding ligand to subvert apoptosis. (PubMed id 22281498)1 Li J....Huang R. (2012)
- Molecular machinery for insertion of tail-anchored mem brane proteins into the endoplasmic reticulum membrane in mammalian cells. (PubMed id 23041287)1 Yamamoto Y. and Sakisaka T. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- CAML promotes prolactin-dependent proliferation of bre ast cancer cells by facilitating prolactin receptor signaling pathways. (PubMed id 21128111)1 Lim J.H....Park J.W. (2011)
|
External Searches for CAMLG gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CAMLG gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CAMLG gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CAMLG gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CAMLG | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CAMLG gene:
Search GeneIP for patents involving CAMLG
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CAMLG gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for CAMLG | | OriGene shRNA RFP for CAMLG | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAMLG | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CAMLG | | | OriGene Protein Over-expression Lysate for CAMLG | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CAMLG | | OriGene 3'-UTR Clone for CAMLG | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAMLG | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAMLG | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CAMLG | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CAMLG | | OriGene Custom Protein Services for CAMLG | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CAMLG | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CAMLG | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAMLG | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAMLG | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAMLG | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAMLG |
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| |  |  |  |  | | | | |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMLG |
|  |  |  | | | | ThermoFisher Antibodies for CAMLG |
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