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Aliases for CAMLG Gene

Aliases for CAMLG Gene

  • Calcium Modulating Ligand 2 3
  • Calcium-Signal Modulating Cyclophilin Ligand 2 3
  • Calcium-Modulating Cyclophilin Ligand 2 3
  • Cyclophilin B-Binding Protein 2 3
  • CAML 3 4

External Ids for CAMLG Gene

Previous GeneCards Identifiers for CAMLG Gene

  • GC05P133724
  • GC05P134588
  • GC05P134106
  • GC05P134150
  • GC05P134102
  • GC05P134074
  • GC05P129260

Summaries for CAMLG Gene

Entrez Gene Summary for CAMLG Gene

  • The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAMLG Gene

CAMLG (Calcium Modulating Ligand) is a Protein Coding gene. Diseases associated with CAMLG include cogan-reese syndrome. Among its related pathways are Ca, cAMP and Lipid Signaling and RANK Signaling in Osteoclasts. GO annotations related to this gene include cell adhesion molecule binding.

UniProtKB/Swiss-Prot for CAMLG Gene

  • Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B

Gene Wiki entry for CAMLG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMLG Gene

Genomics for CAMLG Gene

Regulatory Elements for CAMLG Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CAMLG Gene

Chromosome:
5
Start:
134,737,927 bp from pter
End:
134,752,160 bp from pter
Size:
14,234 bases
Orientation:
Plus strand

Genomic View for CAMLG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAMLG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMLG Gene

Proteins for CAMLG Gene

  • Protein details for CAMLG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49069-CAMLG_HUMAN
    Recommended name:
    Calcium signal-modulating cyclophilin ligand
    Protein Accession:
    P49069
    Secondary Accessions:
    • A1L3Y3

    Protein attributes for CAMLG Gene

    Size:
    296 amino acids
    Molecular mass:
    32953 Da
    Quaternary structure:
    • The N-terminal domain binds to TNFRSF13B/TACI. Interacts with human herpes virus 8/HHV-8 protein K7; this interaction modulates intracellular calcium concentration.

neXtProt entry for CAMLG Gene

Proteomics data for CAMLG Gene at MOPED

Post-translational modifications for CAMLG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAMLG Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CAMLG (CAMLG)

No data available for DME Specific Peptides for CAMLG Gene

Domains & Families for CAMLG Gene

Protein Domains for CAMLG Gene

Suggested Antigen Peptide Sequences for CAMLG Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CAMLG: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CAMLG Gene

Function for CAMLG Gene

Molecular function for CAMLG Gene

GENATLAS Biochemistry:
calcium-modulating cyclophilin ligand,involved in the regulation of calcium signaling in T lymphocytes and other cells (signal transduction)
UniProtKB/Swiss-Prot Function:
Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B

Gene Ontology (GO) - Molecular Function for CAMLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15451437
genes like me logo Genes that share ontologies with CAMLG: view

Phenotypes for CAMLG Gene

genes like me logo Genes that share phenotypes with CAMLG: view

Animal Models for CAMLG Gene

MGI Knock Outs for CAMLG:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CAMLG Gene

Localization for CAMLG Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMLG Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAMLG Gene COMPARTMENTS Subcellular localization image for CAMLG gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for CAMLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 12919676
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CAMLG: view

Pathways & Interactions for CAMLG Gene

genes like me logo Genes that share pathways with CAMLG: view

Pathways by source for CAMLG Gene

1 Cell Signaling Technology pathway for CAMLG Gene
1 GeneGo (Thomson Reuters) pathway for CAMLG Gene

Gene Ontology (GO) - Biological Process for CAMLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001881 receptor recycling IEA --
GO:0006952 defense response TAS 7522304
GO:0007165 signal transduction TAS 7522304
GO:0007173 epidermal growth factor receptor signaling pathway IEA --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with CAMLG: view

No data available for SIGNOR curated interactions for CAMLG Gene

Drugs & Compounds for CAMLG Gene

(3) Drugs for CAMLG Gene - From: DGIdb, DrugBank, NovoSeek, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporine Approved, Investigational Pharma inhibitor, Target, binder Immunosuppressant drug 0
Calcium Nutra 0
CYCLOSPORINE A Pharma 0

(1) Additional Compounds for CAMLG Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
BLyS
genes like me logo Genes that share compounds with CAMLG: view

Transcripts for CAMLG Gene

mRNA/cDNA for CAMLG Gene

Unigene Clusters for CAMLG Gene

Calcium modulating ligand:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAMLG

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAMLG Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4
SP1: -
SP2: - - -
SP3:
SP4: - - - -
SP5:

Relevant External Links for CAMLG Gene

GeneLoc Exon Structure for
CAMLG
ECgene alternative splicing isoforms for
CAMLG

Expression for CAMLG Gene

mRNA expression in normal human tissues for CAMLG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CAMLG Gene

This gene is overexpressed in Bone (27.9) and Fetal Brain (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAMLG Gene



SOURCE GeneReport for Unigene cluster for CAMLG Gene Hs.529846

mRNA Expression by UniProt/SwissProt for CAMLG Gene

P49069-CAMLG_HUMAN
Tissue specificity: Ubiquitous. Highest levels in brain, testis and ovary
genes like me logo Genes that share expression patterns with CAMLG: view

Protein tissue co-expression partners for CAMLG Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CAMLG Gene

Orthologs for CAMLG Gene

This gene was present in the common ancestor of chordates.

Orthologs for CAMLG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CAMLG 35
  • 92.58 (n)
  • 93.84 (a)
CAMLG 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAMLG 35
  • 91.78 (n)
  • 93.92 (a)
CAMLG 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Caml 35
  • 83.45 (n)
  • 89.46 (a)
Caml 16
Caml 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CAMLG 35
  • 99.55 (n)
  • 99.66 (a)
CAMLG 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Camlg 35
  • 82.14 (n)
  • 87.03 (a)
oppossum
(Monodelphis domestica)
Mammalia CAMLG 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAMLG 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves CAMLG 35
  • 74.76 (n)
  • 75.36 (a)
CAMLG 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAMLG 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia camlg 35
  • 65.91 (n)
  • 65.28 (a)
Str.3785 35
African clawed frog
(Xenopus laevis)
Amphibia MGC53900 35
zebrafish
(Danio rerio)
Actinopterygii camlg 35
  • 54.68 (n)
  • 56.61 (a)
camlg 36
  • 38 (a)
OneToOne
Species with no ortholog for CAMLG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAMLG Gene

ENSEMBL:
Gene Tree for CAMLG (if available)
TreeFam:
Gene Tree for CAMLG (if available)

Paralogs for CAMLG Gene

No data available for Paralogs for CAMLG Gene

Variants for CAMLG Gene

Sequence variations from dbSNP and Humsavar for CAMLG Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_024297 -
VAR_050710 -

Structural Variations from Database of Genomic Variants (DGV) for CAMLG Gene

Variant ID Type Subtype PubMed ID
nsv830493 CNV Loss 17160897

Variation tolerance for CAMLG Gene

Residual Variation Intolerance Score: 28.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.38; 27.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAMLG Gene

HapMap Linkage Disequilibrium report
CAMLG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMLG Gene

Disorders for CAMLG Gene

MalaCards: The human disease database

(1) MalaCards diseases for CAMLG Gene - From: DISEASES

Disorder Aliases PubMed IDs
cogan-reese syndrome
- elite association
Search CAMLG in MalaCards View complete list of genes associated with diseases

Relevant External Links for CAMLG

Genetic Association Database (GAD)
CAMLG
Human Genome Epidemiology (HuGE) Navigator
CAMLG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAMLG
genes like me logo Genes that share disorders with CAMLG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAMLG Gene

Publications for CAMLG Gene

  1. The gene for calcium-modulating cyclophilin ligand (CAMLG) is located on human chromosome 5q23 and a syntenic region of mouse chromosome 13. (PMID: 8824814) Bram R.J. … Copeland N.G. (Genomics 1996) 2 23 67
  2. Solution structure of the cysteine-rich domain in Fn14, a member of the tumor necrosis factor receptor superfamily. (PMID: 19241374) He F. … Yokoyama S. (Protein Sci. 2009) 23 67
  3. Gut-associated lymphoid tissue contains the molecular machinery to support T-cell-dependent and T-cell-independent class switch recombination. (PMID: 19741596) Barone F. … Spencer J. (Mucosal Immunol 2009) 23 67
  4. Atacicept (TACI-Ig) inhibits growth of TACI(high) primary myeloma cells in SCID-hu mice and in coculture with osteoclasts. (PMID: 18046446) Yaccoby S. … Shaughnessy J.D. (Leukemia 2008) 23 67
  5. Pharmacokinetics and biological activity of atacicept in patients with rheumatoid arthritis. (PMID: 18303125) Nestorov I. … Visich J. (J Clin Pharmacol 2008) 23 67

Products for CAMLG Gene

Sources for CAMLG Gene

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