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CAMLG Gene

protein-coding   GIFtS: 59
GCID: GC05P134074

Calcium Modulating Ligand

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calcium Modulating Ligand1 2
Calcium-Modulating Cyclophilin Ligand1 2
Calcium-Signal Modulating Cyclophilin Ligand1 2
Cyclophilin B-Binding Protein1 2
CAML2 3
Calcium Signal-Modulating Cyclophilin Ligand2

External Ids:    HGNC: 14711   Entrez Gene: 8192   Ensembl: ENSG000001646157   OMIM: 6011185   UniProtKB: P490693   

Export aliases for CAMLG gene to outside databases

Previous GC identifers: GC05P133724 GC05P134588 GC05P134106 GC05P134150 GC05P134102 GC05P129260


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CAMLG Gene:
The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that
normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key
signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A,
binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of
calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction
pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. (provided by RefSeq,
Jul 2008)

GeneCards Summary for CAMLG Gene:
CAMLG (calcium modulating ligand) is a protein-coding gene. Diseases associated with CAMLG include polyhydramnios, and congenital diaphragmatic hernia.

UniProtKB/Swiss-Prot: CAMLG_HUMAN, P49069
Function: Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to
cyclophilin B

Gene Wiki entry for CAMLG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the CAMLG gene promoter:
         MEF-2A   AREB6   C/EBPbeta   AML1a   NCX/Ncx   aMEF-2   Cdc5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCAMLG promoter sequence
   Search Chromatin IP Primers for CAMLG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CAMLG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q23

CAMLG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAMLG gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P134074:  view genomic region     (about GC identifiers)

Start:
134,074,170 bp from pter      End:
134,087,850 bp from pter
Size:
13,681 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CAMLG_HUMAN, P49069 (See protein sequence)
Recommended Name: Calcium signal-modulating cyclophilin ligand  
Size: 296 amino acids; 32953 Da
Subunit: The N-terminal domain binds to TNFRSF13B/TACI. Interacts with human herpes virus 8/HHV-8 protein K7; this
interaction modulates intracellular calcium concentration
Secondary accessions: A1L3Y3

Explore the universe of human proteins at neXtProt for CAMLG: NX_P49069

Explore proteomics data for CAMLG at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CAMLG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001736.1  
    ENSEMBL proteins: 
     ENSP00000297156   ENSP00000427331  

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    Cloud-Clone Corp. CLIAs for CAMLG


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR016719 Ca_signal-mod_cyclophilin_lig

    Graphical View of Domain Structure for InterPro Entry P49069

    ProtoNet protein and cluster: P49069


    CAMLG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAMLG_HUMAN, P49069
    Function: Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to
    cyclophilin B

         Genatlas biochemistry entry for CAMLG:
    calcium-modulating cyclophilin ligand,involved in the regulation of calcium signaling in T lymphocytes and other
    cells (signal transduction)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15451437
    GO:0050839cell adhesion molecule binding IEA--
         
    CAMLG for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Caml):
     cellular  hematopoietic system  immune system  mortality/aging 

    CAMLG for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Camltm1Rjb for CAMLG

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CAMLG
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CAMLG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAMLG
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAMLG

    miRNA
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    miRTarBase miRNAs that target CAMLG:
    hsa-mir-484 (MIRT041724), hsa-mir-615-3p (MIRT039963)

    Block miRNA regulation of human, mouse, rat CAMLG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CAMLG (see all 14):
    hsa-miR-579 hsa-miR-26a-2* hsa-miR-520d-5p hsa-miR-4251 hsa-miR-551b* hsa-miR-374c hsa-miR-513b hsa-miR-1303
    SwitchGear 3'UTR luciferase reporter plasmidCAMLG 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CAMLG
    Predesigned siRNA for gene silencing in human, mouse, rat CAMLG

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: CAMLG (NM_001745)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAMLG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMLG

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMLG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CAMLG_HUMAN, P49069: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytosol1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA12919676
    GO:0016021integral component of membrane IEA--

    CAMLG for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CAMLG About    
    See pathways by source

    SuperPathContained pathways About
    1RANK Signaling in Osteoclasts
    Apoptosis and survival APRIL and BAFF signaling0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for CAMLG
        Apoptosis and survival APRIL and BAFF signaling


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CAMLG
    Interactions:

        GeneGlobe Interaction Network for CAMLG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for CAMLG (P490691, 3 ENSP000002971564) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206478P466951, 3EBI-1748958,EBI-1748945 I2D: score=2 
    ENSG00000227231P466951, 3EBI-1748958,EBI-1748945 I2D: score=2 
    ENSG00000230128P466951, 3EBI-1748958,EBI-1748945 I2D: score=2 
    ENSG00000235030P466951, 3EBI-1748958,EBI-1748945 I2D: score=2 
    ENSG00000237155P466951, 3EBI-1748958,EBI-1748945 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001881receptor recycling IEA--
    GO:0006952defense response TAS7522304
    GO:0007165signal transduction TAS7522304
    GO:0007173epidermal growth factor receptor signaling pathway IEA--
    GO:0016032viral process IEA--

    CAMLG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CAMLG

    1 HMDB Compound for CAMLG    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for CAMLG    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    CyclosporineCiclosporin (see all 4)59865-13-3targetbinder20674565 17016423 20637127 20602248 17139284 20927389

    2 Novoseek inferred chemical compound relationships for CAMLG gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    blys 87.3 5 15697217 (1), 15564725 (1), 18303125 (1), 16239971 (1)
    calcium 32 18 9632697 (5), 7522304 (2), 8621480 (2), 8824814 (1) (see all 6)



    CAMLG for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CAMLG gene: 
    NM_001745.3  

    Unigene Cluster for CAMLG:

    Calcium modulating ligand
    Hs.529846  [show with all ESTs]
    Unigene Representative Sequence: NM_001745
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000297156(uc003kzt.3 uc003kzu.3) ENST00000514518
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CAMLG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CAMLG (see all 14):
    hsa-miR-579 hsa-miR-26a-2* hsa-miR-520d-5p hsa-miR-4251 hsa-miR-551b* hsa-miR-374c hsa-miR-513b hsa-miR-1303
    SwitchGear 3'UTR luciferase reporter plasmidCAMLG 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CAMLG
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMLG
    Primer
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    OriGene qPCR primer pairs and template standards for CAMLG
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      QuantiTect SYBR Green Assays in human, mouse, rat CAMLG
      QuantiFast Probe-based Assays in human, mouse, rat CAMLG

    Additional mRNA sequence: 

    AF068179.1 AK093716.1 AK313156.1 BC063532.1 BC130325.1 U18242.1 

    10 DOTS entries:

    DT.40202552  DT.100781346  DT.120885372  DT.99929720  DT.120885368  DT.91744677  DT.100035013  DT.401091 
    DT.95189805  DT.92023857 

    Selected AceView cDNA sequences (see all 200):

    AI367491 T82308 CR596597 BU948574 CB215757 BX458495 BP369172 AW007129 
    AA934811 AI224069 BG331932 BM696198 BG655744 BP351497 AW006849 AW611860 
    BQ575878 BG285233 AA366860 BM459213 CR593088 NM_001745 AA384656 AA719413 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CAMLG    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4
    SP1:                          -               
    SP2:              -     -     -               
    SP3:                                          
    SP4:              -     -     -     -         
    SP5:                                          


    ECgene alternative splicing isoforms for CAMLG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CAMLG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CAMLG Expression
    About this image

    CAMLG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CAMLG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.529846

    UniProtKB/Swiss-Prot: CAMLG_HUMAN, P49069
    Tissue specificity: Ubiquitous. Highest levels in brain, testis and ovary

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMLG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CAMLG gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Caml1 , 5 calcium modulating ligand1, 5 83.45(n)1
    89.46(a)1
      13 (30.06 cM)5
    123281  NM_007596.21  NP_031622.21 
     556230055 
    chicken
    (Gallus gallus)
    Aves CAMLG1 calcium modulating ligand 74.76(n)
    75.36(a)
      395808  NM_204962.1  NP_990293.1 
    lizard
    (Anolis carolinensis)
    Reptilia CAMLG6
    calcium modulating ligand
    71(a)
    1 ↔ 1
    GL343223.1(229984-239848)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC539002 similar to calcium modulating ligand 73.41(n)    BC041555.1 
    zebrafish
    (Danio rerio)
    Actinopterygii camlg1 calcium modulating ligand 54.68(n)
    56.61(a)
      404622  NM_207090.2  NP_996973.2 


    ENSEMBL Gene Tree for CAMLG (if available)
    TreeFam Gene Tree for CAMLG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for CAMLG (see all 281)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs68656171,2
    C,F,H--134072191(+) CACTTC/ATTTTT 1 -- us2k1 trp316Minor allele frequency- A:0.07NS EA WA NA 2338
    rs1862781681,2
    --134072415(+) AGTAAA/GTCATT 1 -- us2k10--------
    rs1904779141,2
    --134072525(+) GACTGC/TATTGC 1 -- us2k10--------
    rs1834448831,2
    --134072654(+) GGCCCC/GATCAT 1 -- us2k10--------
    rs1886616501,2
    --134072751(+) CAAGCA/CCGACT 1 -- us2k10--------
    rs1932306741,2
    --134072829(+) TCAAGC/TGATCC 1 -- us2k10--------
    rs1827010421,2
    --134073053(+) AGTAGC/TTGGGA 1 -- us2k10--------
    rs1878212651,2
    --134073072(+) GCATGC/TCACCA 1 -- us2k10--------
    rs1927932101,2
    --134073278(+) CTGTCA/GCCCAG 1 -- us2k10--------
    rs1119661421,2
    C--134073380(+) AATGTGCACG   
      AAAG
    /-
    GTTTC
    1 -- us2k11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for CAMLG (134074170 - 134087850 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CAMLG:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830493CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CAMLG
    DNA2.0 Custom Variant and Variant Library Synthesis for CAMLG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601118    OMIM disorders: --

    14 diseases for CAMLG:    
    About MalaCards
    polyhydramnios    congenital diaphragmatic hernia    common variable immunodeficiency    kaposi's sarcoma
    acute myeloid leukemia    sarcoma    myeloid leukemia    atherosclerosis
    rheumatoid arthritis    arthritis    myeloma    hiv-1
    leukemia    breast cancer

    1 disease from the University of Copenhagen DISEASES database for CAMLG:
    Common variable immunodeficiency

    CAMLG for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for CAMLG gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 29.8 2 10920230 (1), 9311921 (1)
    tumors 5.67 2 10920230 (1), 9311921 (1)

    Genetic Association Database (GAD): CAMLG
    Human Genome Epidemiology (HuGE) Navigator: CAMLG (1 document)

    Export disorders for CAMLG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CAMLG gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with CAMLG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Calcium signalling in T cells stimulated by a cyclophilin B-binding protein. (PubMed id 7522304)1, 2, 9 Bram R.J. and Crabtree G.R. (Nature 1994)
    2. The gene for calcium-modulating cyclophilin ligand (CAMLG) is located on human chromosome 5q23 and a syntenic region of mouse chromosome 13. (PubMed id 8824814)1, 3, 9 Bram R.J....Copeland N.G. (Genomics 1996)
    3. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (J. Hum. Genet. 2010)
    4. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    5. Kaposi's sarcoma-associated herpesvirus mitochondrial K7 protein targets a cellular calcium-modulating cyclophilin ligand to modulate intracellular calcium concentration and inhibit apoptosis. (PubMed id 12388711)1, 2 Feng P....Jung J.U. (J. Virol. 2002)
    6. Calcium-modulating cyclophilin ligand desensitizes hormone-evoked calcium release. (PubMed id 11006089)1, 9 Tovey S.C....Bram R.J. (Biochem. Biophys. Res. Commun. 2000)
    7. Co-localization of calcium-modulating cyclophilin ligand with intracellular calcium pools. (PubMed id 9632697)1, 9 Holloway M.P. and Bram R.J. (J. Biol. Chem. 1998)
    8. NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily. (PubMed id 9311921)1, 9 von Buelow G.-U. and Bram R.J. (Science 1997)
    9. A novel interaction between calcium-modulating cyclophilin ligand and Basigin regulates calcium signaling and matrix metalloproteinase activities in human melanoma cells. (PubMed id 23879967)1 Long T....Chen X. (Cancer Lett. 2013)
    10. Dengue virus utilizes calcium modulating cyclophilin-binding ligand to subvert apoptosis. (PubMed id 22281498)1 Li J....Huang R. (Biochem. Biophys. Res. Commun. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
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      Query String
    PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 819 HGNC: 1471 AceView: CAMLG Ensembl:ENSG00000164615 euGenes: HUgn819
    ECgene: CAMLG H-InvDB: CAMLG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CAMLG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CAMLG gene:
    Search GeneIP for patents involving CAMLG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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