Aliases for CAMLG Gene
External Ids for CAMLG Gene
Previous GeneCards Identifiers for CAMLG Gene
The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]
GeneCards Summary for CAMLG Gene
CAMLG (Calcium Modulating Ligand) is a Protein Coding gene. Diseases associated with CAMLG include Cogan-Reese Syndrome. Among its related pathways are RANK Signaling in Osteoclasts and Ca, cAMP and Lipid Signaling. GO annotations related to this gene include cell adhesion molecule binding.
UniProtKB/Swiss-Prot for CAMLG Gene
Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B.