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Aliases for CAMKV Gene

Aliases for CAMKV Gene

  • CaM Kinase Like Vesicle Associated 2 3 5
  • Vesicle-Associated Calmodulin-Binding Protein 3
  • CaM Kinase-Like Vesicle-Associated Protein 3
  • Testis Tissue Sperm-Binding Protein Li 52e 3
  • CaM Kinase-Like Vesicle-Associated 2
  • VACAMKL 3
  • 1G5 3

External Ids for CAMKV Gene

Previous GeneCards Identifiers for CAMKV Gene

  • GC03M049875
  • GC03M049895

Summaries for CAMKV Gene

GeneCards Summary for CAMKV Gene

CAMKV (CaM Kinase Like Vesicle Associated) is a Protein Coding gene. Among its related pathways are MAPK-Erk Pathway and Development ERBB-family signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CAMK1.

UniProtKB/Swiss-Prot for CAMKV Gene

  • Does not appear to have detectable kinase activity.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMKV Gene

Genomics for CAMKV Gene

Regulatory Elements for CAMKV Gene

Enhancers for CAMKV Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G049872 1.2 FANTOM5 ENCODE 0.7 -3.0 -3010 2.4 ELF3 PKNOX1 MLX ARID4B BMI1 DMAP1 ZNF48 ZSCAN9 RAD21 THAP11 RBM6 ZMYND10 GNAI2 HYAL3 NAT6 CAMKV ACTBP13
GH03G049868 1.2 Ensembl ENCODE 0.7 +0.8 826 2.0 HDAC1 NFRKB ARID4B ZNF48 RAD21 ZNF335 GLIS2 EGR1 ZNF143 IKZF2 RBM6 ENSG00000230698 ENSG00000228008 MST1R IP6K1 PHF5EP CAMKV RN7SL217P
GH03G049867 0.7 ENCODE 0.7 +2.3 2250 0.2 SAP130 MIER1 ZNF133 ARID4B NCOA1 MIER2 REST ZSCAN9 RARA HDAC2 IP6K1 ENSG00000230698 ENSG00000228008 MST1R ENSG00000223343 PHF5EP NICN1 CAMKV RN7SL217P
GH03G049869 0.7 ENCODE 0.7 +2.0 2000 0.2 SAP130 MIER1 NFRKB ZNF133 ZNF223 ARID4B NCOA1 REST ZSCAN9 SMARCA4 IP6K1 ENSG00000230698 MST1R ENSG00000228008 ENSG00000223343 PHF5EP NICN1 CAMKV RN7SL217P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CAMKV on UCSC Golden Path with GeneCards custom track

Genomic Location for CAMKV Gene

Chromosome:
3
Start:
49,857,981 bp from pter
End:
49,870,222 bp from pter
Size:
12,242 bases
Orientation:
Minus strand

Genomic View for CAMKV Gene

Genes around CAMKV on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAMKV Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAMKV Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMKV Gene

Proteins for CAMKV Gene

  • Protein details for CAMKV Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCB2-CAMKV_HUMAN
    Recommended name:
    CaM kinase-like vesicle-associated protein
    Protein Accession:
    Q8NCB2
    Secondary Accessions:
    • A6NFD4
    • Q6FIB8
    • Q8NBS8
    • Q8NC85
    • Q8NDU4
    • Q8WTT8
    • Q9BQC9
    • Q9H0Q5

    Protein attributes for CAMKV Gene

    Size:
    501 amino acids
    Molecular mass:
    54354 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with calmodulin, in the presence of calcium.

    Alternative splice isoforms for CAMKV Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAMKV Gene

Post-translational modifications for CAMKV Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CAMKV Gene

Domains & Families for CAMKV Gene

Gene Families for CAMKV Gene

Protein Domains for CAMKV Gene

Graphical View of Domain Structure for InterPro Entry

Q8NCB2

UniProtKB/Swiss-Prot:

CAMKV_HUMAN :
  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Domain:
  • The protein kinase domain is predicted to be catalytically inactive.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with CAMKV: view

Function for CAMKV Gene

Molecular function for CAMKV Gene

UniProtKB/Swiss-Prot Function:
Does not appear to have detectable kinase activity.

Gene Ontology (GO) - Molecular Function for CAMKV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004683 calmodulin-dependent protein kinase activity IBA --
GO:0005516 calmodulin binding IEA,IBA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with CAMKV: view
genes like me logo Genes that share phenotypes with CAMKV: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CAMKV

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CAMKV

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CAMKV Gene

Localization for CAMKV Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMKV Gene

Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Predominantly observed in association with the plasma membrane of soma and in neurites, both axons and dendrites. May be associated with vesicular structures (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAMKV gene
Compartment Confidence
plasma membrane 3
nucleus 3
cytosol 3
mitochondrion 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CAMKV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with CAMKV: view

Pathways & Interactions for CAMKV Gene

genes like me logo Genes that share pathways with CAMKV: view

Pathways by source for CAMKV Gene

Gene Ontology (GO) - Biological Process for CAMKV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IBA --
GO:0018107 peptidyl-threonine phosphorylation IBA --
GO:0035556 intracellular signal transduction IBA --
genes like me logo Genes that share ontologies with CAMKV: view

No data available for SIGNOR curated interactions for CAMKV Gene

Drugs & Compounds for CAMKV Gene

(1) Drugs for CAMKV Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CAMKV: view

Transcripts for CAMKV Gene

Unigene Clusters for CAMKV Gene

CaM kinase-like vesicle-associated:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CAMKV

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAMKV Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^
SP1: - - -
SP2: - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - - -
SP6: -
SP7:
SP8:
SP9: - -
SP10: - - - - - -

ExUns: 12a · 12b · 12c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for CAMKV Gene

GeneLoc Exon Structure for
CAMKV
ECgene alternative splicing isoforms for
CAMKV

Expression for CAMKV Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAMKV Gene

mRNA differential expression in normal tissues according to GTEx for CAMKV Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x10.4), Brain - Cortex (x6.9), Brain - Putamen (basal ganglia) (x6.8), Brain - Caudate (basal ganglia) (x6.2), Brain - Frontal Cortex (BA9) (x5.2), Brain - Anterior cingulate cortex (BA24) (x4.8), and Brain - Hippocampus (x4.4).

Protein differential expression in normal tissues from HIPED for CAMKV Gene

This gene is overexpressed in Brain (24.4), Fetal Brain (22.0), and Frontal cortex (21.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CAMKV Gene



Protein tissue co-expression partners for CAMKV Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CAMKV Gene:

CAMKV

SOURCE GeneReport for Unigene cluster for CAMKV Gene:

Hs.145156

Evidence on tissue expression from TISSUES for CAMKV Gene

  • Nervous system(5)
  • Lung(4)
genes like me logo Genes that share expression patterns with CAMKV: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAMKV Gene

Orthologs for CAMKV Gene

This gene was present in the common ancestor of animals.

Orthologs for CAMKV Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAMKV 34 35
  • 99.67 (n)
cow
(Bos Taurus)
Mammalia CAMKV 34 35
  • 92.17 (n)
dog
(Canis familiaris)
Mammalia CAMKV 34 35
  • 91.28 (n)
mouse
(Mus musculus)
Mammalia Camkv 34 16 35
  • 88.82 (n)
rat
(Rattus norvegicus)
Mammalia Camkv 34
  • 88.16 (n)
oppossum
(Monodelphis domestica)
Mammalia CAMKV 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 64 (a)
OneToMany
-- 35
  • 62 (a)
OneToMany
chicken
(Gallus gallus)
Aves CAMKV 34 35
  • 80.05 (n)
lizard
(Anolis carolinensis)
Reptilia CAMKV 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia camkv 34
  • 77.17 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26466 34
zebrafish
(Danio rerio)
Actinopterygii camkva 35
  • 80 (a)
OneToMany
LOC567243 34
  • 78.48 (n)
camkvb 35
  • 71 (a)
OneToMany
camkvl 35
  • 33 (a)
OneToMany
zgc63506 34
fruit fly
(Drosophila melanogaster)
Insecta CaMKII 35
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-43 35
  • 20 (a)
OneToMany
Species where no ortholog for CAMKV was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAMKV Gene

ENSEMBL:
Gene Tree for CAMKV (if available)
TreeFam:
Gene Tree for CAMKV (if available)

Paralogs for CAMKV Gene

Variants for CAMKV Gene

Sequence variations from dbSNP and Humsavar for CAMKV Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_041337 A colorectal adenocarcinoma sample
VAR_041338 An ovarian serous carcinoma sample
VAR_041339 A colorectal adenocarcinoma sample
rs1000752391 -- 49,870,296(+) CAGAT(-/GGGCAGTC)GGGCT upstream-variant-2KB
rs1000921712 -- 49,863,152(+) GAATA(C/T)ATATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAMKV Gene

Variant ID Type Subtype PubMed ID
nsv834688 CNV loss 17160897

Variation tolerance for CAMKV Gene

Residual Variation Intolerance Score: 41.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAMKV Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAMKV

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMKV Gene

Disorders for CAMKV Gene

Relevant External Links for CAMKV

Genetic Association Database (GAD)
CAMKV
Human Genome Epidemiology (HuGE) Navigator
CAMKV
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAMKV

No disorders were found for CAMKV Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAMKV Gene

Publications for CAMKV Gene

  1. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PMID: 19367581) So H.C. … Sham P.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64

Products for CAMKV Gene

Sources for CAMKV Gene

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