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Aliases for CAMKV Gene

Aliases for CAMKV Gene

  • CaM Kinase-Like Vesicle-Associated 2 3
  • 1G5 3 6
  • Vesicle-Associated Calmodulin-Binding Protein 3
  • CaM Kinase-Like Vesicle-Associated Protein 3
  • VACAMKL 3

External Ids for CAMKV Gene

Summaries for CAMKV Gene

GeneCards Summary for CAMKV Gene

CAMKV (CaM Kinase-Like Vesicle-Associated) is a Protein Coding gene. Among its related pathways are EGFR Signaling Pathway. GO annotations related to this gene include protein kinase activity and calmodulin binding. An important paralog of this gene is DCX.

UniProtKB/Swiss-Prot for CAMKV Gene

  • Does not appear to have detectable kinase activity

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMKV Gene

Genomics for CAMKV Gene

Genomic Location for CAMKV Gene

Start:
49,857,981 bp from pter
End:
49,870,222 bp from pter
Size:
12,242 bases
Orientation:
Minus strand

Genomic View for CAMKV Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAMKV Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMKV Gene

Regulatory Elements for CAMKV Gene

Proteins for CAMKV Gene

  • Protein details for CAMKV Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCB2-CAMKV_HUMAN
    Recommended name:
    CaM kinase-like vesicle-associated protein
    Protein Accession:
    Q8NCB2
    Secondary Accessions:
    • A6NFD4
    • Q6FIB8
    • Q8NBS8
    • Q8NC85
    • Q8NDU4
    • Q8WTT8
    • Q9BQC9
    • Q9H0Q5

    Protein attributes for CAMKV Gene

    Size:
    501 amino acids
    Molecular mass:
    54354 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with calmodulin, in the presence of calcium.

    Alternative splice isoforms for CAMKV Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAMKV Gene

Proteomics data for CAMKV Gene at MOPED

Post-translational modifications for CAMKV Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CAMKV Gene

Domains for CAMKV Gene

Gene Families for CAMKV Gene

UniProtKB/Swiss-Prot:

CAMKV_HUMAN
Domain:
  • The protein kinase domain is predicted to be catalytically inactive:
    • Q8NCB2
  • Contains 1 protein kinase domain.:
    • Q8NCB2
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.:
    • Q8NCB2
genes like me logo Genes that share domains with CAMKV: view

Function for CAMKV Gene

Molecular function for CAMKV Gene

UniProtKB/Swiss-Prot Function: Does not appear to have detectable kinase activity

Gene Ontology (GO) - Molecular Function for CAMKV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005516 calmodulin binding IEA --
GO:0005524 ATP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with CAMKV: view
genes like me logo Genes that share phenotypes with CAMKV: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CAMKV Gene

Localization for CAMKV Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMKV Gene

Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Predominantly observed in association with the plasma membrane of soma and in neurites, both axons and dendrites. May be associated with vesicular structures (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAMKV Gene COMPARTMENTS Subcellular localization image for CAMKV gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 2
cytoskeleton 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CAMKV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0030659 cytoplasmic vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle --
genes like me logo Genes that share ontologies with CAMKV: view

Pathways for CAMKV Gene

SuperPathways for CAMKV Gene

Superpath Contained pathways
1 EGFR Signaling Pathway
genes like me logo Genes that share pathways with CAMKV: view

Pathways by source for CAMKV Gene

1 Sino Biological pathway for CAMKV Gene

Gene Ontology (GO) - Biological Process for CAMKV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with CAMKV: view

Compounds for CAMKV Gene

(1) HMDB Compounds for CAMKV Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with CAMKV: view

Transcripts for CAMKV Gene

Unigene Clusters for CAMKV Gene

CaM kinase-like vesicle-associated:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAMKV Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^
SP1: - - -
SP2: - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - - -
SP6: -
SP7:
SP8:
SP9: - -
SP10: - - - - - -

ExUns: 12a · 12b · 12c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for CAMKV Gene

GeneLoc Exon Structure for
CAMKV
ECgene alternative splicing isoforms for
CAMKV

Expression for CAMKV Gene

mRNA expression in normal human tissues for CAMKV Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAMKV Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (10.4), Brain - Cortex (6.9), Brain - Putamen (basal ganglia) (6.8), Brain - Caudate (basal ganglia) (6.2), Brain - Frontal Cortex (BA9) (5.2), Brain - Anterior cingulate cortex (BA24) (4.8), and Brain - Hippocampus (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAMKV Gene

SOURCE GeneReport for Unigene cluster for CAMKV Gene Hs.145156

genes like me logo Genes that share expressions with CAMKV: view

Orthologs for CAMKV Gene

This gene was present in the common ancestor of animals.

Orthologs for CAMKV Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAMKV 36
  • 99.67 (n)
  • 99.8 (a)
CAMKV 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CAMKV 36
  • 92.17 (n)
  • 92.77 (a)
CAMKV 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAMKV 36
  • 91.28 (n)
  • 93.81 (a)
CAMKV 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Camkv 36
  • 88.82 (n)
  • 93.41 (a)
Camkv 16
Camkv 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CAMKV 37
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 64 (a)
OneToMany
-- 37
  • 62 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Camkv 36
  • 88.16 (n)
  • 92.42 (a)
chicken
(Gallus gallus)
Aves CAMKV 36
  • 80.05 (n)
  • 87.05 (a)
CAMKV 37
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAMKV 37
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.26466 36
tropical clawed frog
(Silurana tropicalis)
Amphibia camkv 36
  • 77.17 (n)
  • 88.79 (a)
zebrafish
(Danio rerio)
Actinopterygii camkva 37
  • 80 (a)
OneToMany
camkvb 37
  • 71 (a)
OneToMany
camkvl 37
  • 33 (a)
OneToMany
LOC567243 36
  • 78.48 (n)
  • 88.48 (a)
zgc63506 36
fruit fly
(Drosophila melanogaster)
Insecta CaMKII 37
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-43 37
  • 20 (a)
OneToMany
Species with no ortholog for CAMKV:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAMKV Gene

ENSEMBL:
Gene Tree for CAMKV (if available)
TreeFam:
Gene Tree for CAMKV (if available)

Paralogs for CAMKV Gene

genes like me logo Genes that share paralogs with CAMKV: view

Variants for CAMKV Gene

Sequence variations from dbSNP and Humsavar for CAMKV Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs952594 -- 49,870,590(+) CCTGT(A/G)TGGCA upstream-variant-2KB
rs1320312 -- 49,868,568(-) GGCTG(G/T)CTGTT intron-variant
rs1320313 -- 49,862,523(+) CCAGG(A/G)GGGGC intron-variant
rs2352981 -- 49,870,340(+) GTAAA(C/T)ACACA upstream-variant-2KB
rs2681780 -- 49,860,397(+) CCTTC(C/T)AGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAMKV Gene

Variant ID Type Subtype PubMed ID
nsv834688 CNV Loss 17160897
nsv876766 CNV Loss 21882294

Relevant External Links for CAMKV Gene

HapMap Linkage Disequilibrium report
CAMKV

Disorders for CAMKV Gene

Relevant External Links for CAMKV

Genetic Association Database (GAD)
CAMKV
Human Genome Epidemiology (HuGE) Navigator
CAMKV
genes like me logo Genes that share disorders with CAMKV: view

No data available for UniProtKB/Swiss-Prot for CAMKV Gene

Publications for CAMKV Gene

  1. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PMID: 19367581) So H.C. … Sham P.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 49
  2. 1G5: a calmodulin-binding, vesicle-associated, protein kinase-like protein enriched in forebrain neurites. (PMID: 8283228) Godbout M. … Sutcliffe J.G. (J. Neurosci. 1994) 3 23
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for CAMKV Gene

  • Addgene plasmids for CAMKV

Sources for CAMKV Gene

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