CAMKMT Gene
protein-coding GIFtS: 44
GCID: GC02P044589
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calmodulin-lysine N-methyltransferase(Previous name: chromosome 2 open reading frame 34 )
(Previous symbol: C2orf34)
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Aliases
for CAMKMT gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Calmodulin-Lysine N-Methyltransferase1 2 | | Chromosome 2 Open Reading Frame 341 | | C2orf341 2 3 | | Cam2 | | CLNMT1 2 3 | | KMT2 | | CaM KMT2 3 | | EC 2.1.1.603 |
Export aliases for CAMKMT gene to outside databases |
Summaries
for CAMKMT gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CAMKMT:
This gene encodes a class I protein methyltransferase that acts in the formation of trimethyllysine in calmodulin. Theprotein contains a AdoMet-binding motif and may play a role in calcium-dependent signaling. (provided by RefSeq, Sep2012)
UniProtKB/Swiss-Prot: CMKMT_HUMAN, Q7Z624Function: Catalyzes the trimethylation of 'Lys-116' in calmodulin
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Genomic Views
for CAMKMT gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CAMKMT
Other transcription factors
Search SABiosciences Chromatin IP Primers for CAMKMT
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAMKMT |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p21 Ensembl cytogenetic band: 2p21 HGNC cytogenetic band: 2p21CAMKMT Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P044589: view genomic region
(about GC identifiers)
Start:
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44,589,043 bp from pter |
End:
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44,999,731 bp from pter |
Size:
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410,689 bases |
Orientation:
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plus strand |
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Proteins
for CAMKMT gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CMKMT_HUMAN, Q7Z624 (See
protein sequence)Recommended Name: Calmodulin-lysine N-methyltransferase Size: 323 amino acids; 36128 Da
Subunit: Monomer (By similarity)
Subcellular location: Cytoplasm (By similarity)
Secondary accessions: Q4ZG15 Q53SS6 Q8N6P5 Q9H5G8Alternative splicing: 2 isoforms: Q7Z624-1 Q7Z624-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CAMKMT: NX_Q7Z624
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7Z624
CAMKMT Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079042.1
ENSEMBL proteins: ENSP00000385587 ENSP00000384039 ENSP00000367755 ENSP00000385124 ENSP00000406936 ENSP00000407594 ENSP00000410783
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
CAMKMT for ontologies About GeneDecksing
CAMKMT Antibody Products:
Assay Products for CAMKMT: |
Protein
Domains /
Families
for CAMKMT gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CAMKMT for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7Z624ProtoNet protein and cluster: Q7Z624 UniProtKB/Swiss-Prot: CMKMT_HUMAN, Q7Z624Similarity: Belongs to the CLNMT methyltransferase family |
Function
for CAMKMT gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CMKMT_HUMAN, Q7Z624Function: Catalyzes the trimethylation of 'Lys-116' in calmodulinCatalytic activity: S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulinN(6)-methyl-L-lysineEnzyme Number (IUBMB): EC 2.1.1.601
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAMKMT (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAMKMT (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CAMKMT (NM_024766) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CAMKMT | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMKMT |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMKMT |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0018025 | calmodulin-lysine N-methyltransferase activity |
IEA | -- |
CAMKMT for ontologies About GeneDecksing
|
Pathways & Interactions
for CAMKMT gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CAMKMT
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for CAMKMT (ENSP000003677554) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for CAMKMT gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CAMKMT
Search CenterWatch for drugs/clinical trials and news about CAMKMT / CMKMT
|
Transcripts
for CAMKMT gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CAMKMT gene: NM_024766.4 Unigene Cluster for CAMKMT: Calmodulin-lysine N-methyltransferase Hs.468349 [show with all ESTs]Unigene Representative Sequence: NM_0247669 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000402247 ENST00000407131 ENST00000378494(uc002rum.2) ENST00000403853(uc002rul.2)
ENST00000454433 ENST00000477623 ENST00000428929 ENST00000428993 ENST00000477830
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAMKMT (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAMKMT (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CAMKMT (NM_024766) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CAMKMT | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMKMT |
Additional cDNA sequence: AK027104.1 BC029359.1 BC053733.1 8 DOTS entries: DT.109875 DT.97807141 DT.91642793 DT.100674343 DT.304751 DT.91734788 DT.100804795 DT.95269083 24/54 AceView cDNA sequences (see all 54): CR616776 CR604494 BU556609 NM_024766 BQ229112 BM509760 CA442012 CR594532 AK027104 BX365423 AA992800 BC029359 BX387832 AI458029 BI825782 AL120898 BM505350 AI187783 CN479125 AA922097 BX374940 AA431599 AI363115 BG493126
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for CAMKMT About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 |
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| SP1: | | | | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CAMKMT
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Expression
for CAMKMT gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CAMKMT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTCTTTCCT
About this image
See CAMKMT Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CAMKMT
SOURCE GeneReport for Unigene cluster: Hs.468349
UniProtKB/Swiss-Prot: CMKMT_HUMAN, Q7Z624Tissue specificity: Isoform 1 is expressed in brain,liver, muscle colon and lung. Isoform 2 is expressed in colon,testis, kidney and brain. Isoform 1 and isoform 2 are expressed in normal lymphoblastoid cells but not inlymphoblastoid cells from patients with hypotonia-cystinuria syndrome
SABiosciences Custom PCR Arrays for CAMKMT
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CAMKMT
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CAMKMT | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAMKMT | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAMKMT | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMKMT |
Orthologs
for CAMKMT gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CAMKMT gene from 9/22 species (see all 22) About this table
ENSEMBL Gene Tree for CAMKMT (if available)
TreeFam Gene Tree for CAMKMT (if available) |
Paralogs
for CAMKMT gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CAMKMT gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CAMKMT (44589043 - 44839043 bp, first 250kb of CAMKMT)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CAMKMT: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CAMKMT |
|
Disorders
/ Diseases
for CAMKMT gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CAMKMT for disorders About GeneDecksing
OMIM gene information: 609559
OMIM disorders: --
5  diseases for CAMKMT: About MalaCardshypotonia-cystinuria syndrome cystinuria hypotonia osteoporosis
homocysteine
Export disorders for CAMKMT gene to outside databases
|
Publications
for CAMKMT gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CAMKMT gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with CAMKMT) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Calmodulin methyltransferase is an evolutionarily conserved enzyme that trimethylates Lys-115 in calmodulin. (PubMed id 20975703)1, 2, 3 Magnani R.... Houtz R.L. (2010)
- Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)1 Kennedy R.B....Poland G.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Genome-wide pleiotropy of osteoporosis-related phenot ypes: The Framingham study. (PubMed id 20200953)1 Karasik D....Demissie S. (2010)
- Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)1 Lango Allen H....Hirschhorn J.N. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Cooperation between NRF-2 and YY-1 transcription fact ors is essential for triggering the expression of the PREPL-C2ORF34 bidirection al gene pair. (PubMed id 19575798)1 Huang C.C. and Chang W.S. (2009)
- Deletion of C2orf34, PREPL and SLC3A1 causes atypical hypotonia-cystinuria syndrome. (PubMed id 18234729)1 Chabrol B....Creemers J.W. (2008)
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External Searches for CAMKMT gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CAMKMT gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CAMKMT gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CAMKMT gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CAMKMT | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CAMKMT gene:
Search GeneIP for patents involving CAMKMT
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CAMKMT gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CAMKMT | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAMKMT | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CAMKMT | | | OriGene Protein Over-expression Lysate for CAMKMT | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CAMKMT | | OriGene 3'-UTR Clone for CAMKMT | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAMKMT | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAMKMT | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CAMKMT | | OriGene Custom Protein Services for CAMKMT | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CAMKMT | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CAMKMT | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAMKMT | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAMKMT | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAMKMT | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAMKMT |
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| | | | Search Tocris compounds for CAMKMT |
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 | | | CAMKMT Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMKMT |
|  |  |  | | | | ThermoFisher Antibody for CAMKMT |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMKMT |
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