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Aliases for CAMKMT Gene

Aliases for CAMKMT Gene

  • Calmodulin-Lysine N-Methyltransferase 2 3 5
  • CaM KMT 2 3 4
  • C2orf34 3 4
  • CLNMT 3 4
  • Chromosome 2 Open Reading Frame 34 2
  • EC 4
  • CaM 3
  • KMT 3

External Ids for CAMKMT Gene

Previous HGNC Symbols for CAMKMT Gene

  • C2orf34

Previous GeneCards Identifiers for CAMKMT Gene

  • GC02P044589

Summaries for CAMKMT Gene

Entrez Gene Summary for CAMKMT Gene

  • This gene encodes a class I protein methyltransferase that acts in the formation of trimethyllysine in calmodulin. The protein contains a AdoMet-binding motif and may play a role in calcium-dependent signaling. [provided by RefSeq, Sep 2012]

GeneCards Summary for CAMKMT Gene

CAMKMT (Calmodulin-Lysine N-Methyltransferase) is a Protein Coding gene. Diseases associated with CAMKMT include Atypical Hypotonia-Cystinuria Syndrome and 2P21 Microdeletion Syndrome Without Cystinuria. Among its related pathways are Phototransduction and Lysine degradation. GO annotations related to this gene include calmodulin-lysine N-methyltransferase activity.

UniProtKB/Swiss-Prot for CAMKMT Gene

  • Catalyzes the trimethylation of Lys-116 in calmodulin.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMKMT Gene

Genomics for CAMKMT Gene

Regulatory Elements for CAMKMT Gene

Enhancers for CAMKMT Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CAMKMT on UCSC Golden Path with GeneCards custom track

Promoters for CAMKMT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CAMKMT on UCSC Golden Path with GeneCards custom track

Genomic Location for CAMKMT Gene

44,361,904 bp from pter
44,772,592 bp from pter
410,689 bases
Plus strand

Genomic View for CAMKMT Gene

Genes around CAMKMT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAMKMT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAMKMT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMKMT Gene

Proteins for CAMKMT Gene

  • Protein details for CAMKMT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calmodulin-lysine N-methyltransferase
    Protein Accession:
    Secondary Accessions:
    • Q4ZG15
    • Q53SS6
    • Q8N6P5
    • Q9H5G8

    Protein attributes for CAMKMT Gene

    323 amino acids
    Molecular mass:
    36128 Da
    Quaternary structure:
    • Monomer (By similarity). Interacts with HSP90, probably as a client.

    Three dimensional structures from OCA and Proteopedia for CAMKMT Gene

    Alternative splice isoforms for CAMKMT Gene


neXtProt entry for CAMKMT Gene

Proteomics data for CAMKMT Gene at MOPED

Post-translational modifications for CAMKMT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CAMKMT Gene

Domains & Families for CAMKMT Gene

Protein Domains for CAMKMT Gene

Suggested Antigen Peptide Sequences for CAMKMT Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class I-like SAM-binding methyltransferase superfamily. CLNMT methyltransferase family.
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. CLNMT methyltransferase family.
genes like me logo Genes that share domains with CAMKMT: view

No data available for Gene Families for CAMKMT Gene

Function for CAMKMT Gene

Molecular function for CAMKMT Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N(6)-methyl-L-lysine.
UniProtKB/Swiss-Prot Function:
Catalyzes the trimethylation of Lys-116 in calmodulin.

Enzyme Numbers (IUBMB) for CAMKMT Gene

Phenotypes for CAMKMT Gene

genes like me logo Genes that share phenotypes with CAMKMT: view

Human Phenotype Ontology for CAMKMT Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CAMKMT Gene

MGI Knock Outs for CAMKMT:

Animal Model Products

CRISPR Products

miRNA for CAMKMT Gene

miRTarBase miRNAs that target CAMKMT

No data available for Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for CAMKMT Gene

Localization for CAMKMT Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMKMT Gene

Isoform 1: Cytoplasm. Nucleus.
Isoform 2: Golgi apparatus.

Subcellular locations from

Jensen Localization Image for CAMKMT Gene COMPARTMENTS Subcellular localization image for CAMKMT gene
Compartment Confidence
cytosol 5
nucleus 5
golgi apparatus 3
cytoskeleton 2
extracellular 1

Gene Ontology (GO) - Cellular Components for CAMKMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with CAMKMT: view

Pathways & Interactions for CAMKMT Gene

genes like me logo Genes that share pathways with CAMKMT: view

Pathways by source for CAMKMT Gene

Interacting Proteins for CAMKMT Gene

Gene Ontology (GO) - Biological Process for CAMKMT Gene


No data available for SIGNOR curated interactions for CAMKMT Gene

Drugs & Compounds for CAMKMT Gene

(2) Drugs for CAMKMT Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0
genes like me logo Genes that share compounds with CAMKMT: view

Transcripts for CAMKMT Gene

Unigene Clusters for CAMKMT Gene

Calmodulin-lysine N-methyltransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAMKMT Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - -
SP2: -
SP3: - -

Relevant External Links for CAMKMT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CAMKMT Gene

mRNA expression in normal human tissues for CAMKMT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CAMKMT Gene

This gene is overexpressed in Heart (58.6) and Fetal ovary (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAMKMT Gene

SOURCE GeneReport for Unigene cluster for CAMKMT Gene Hs.468349

mRNA Expression by UniProt/SwissProt for CAMKMT Gene

Tissue specificity: Isoform 1 is expressed in brain,liver, muscle colon and lung. Isoform 2 is expressed in colon, testis, kidney and brain. Isoform 1 and isoform 2 are expressed in normal lymphoblastoid cells but not in lymphoblastoid cells from patients with hypotonia-cystinuria syndrome.
genes like me logo Genes that share expression patterns with CAMKMT: view

Protein tissue co-expression partners for CAMKMT Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for CAMKMT Gene

Orthologs for CAMKMT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAMKMT Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CAMKMT 35
  • 91.23 (n)
  • 87.31 (a)
  • 87 (a)
(Canis familiaris)
Mammalia CAMKMT 35
  • 92.05 (n)
  • 89.47 (a)
  • 89 (a)
(Mus musculus)
Mammalia Camkmt 35
  • 88.24 (n)
  • 83.59 (a)
Camkmt 16
Camkmt 36
  • 84 (a)
(Pan troglodytes)
Mammalia CAMKMT 35
  • 99.69 (n)
  • 99.69 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Camkmt 35
  • 86.89 (n)
  • 84.21 (a)
(Monodelphis domestica)
Mammalia CAMKMT 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia CAMKMT 36
  • 76 (a)
(Gallus gallus)
Aves CAMKMT 35
  • 80.26 (n)
  • 79.28 (a)
(Anolis carolinensis)
Reptilia CAMKMT 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia camkmt 35
  • 72.66 (n)
  • 69.09 (a)
(Danio rerio)
Actinopterygii si:ch73-54n14.2 35
  • 62.32 (n)
  • 62.68 (a)
camkmt 36
  • 60 (a)
CAMKMT (1 of 2) 36
  • 38 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009131 35
  • 48.95 (n)
  • 43.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10947 35
  • 47.03 (n)
  • 40.73 (a)
CG10947 36
  • 24 (a)
(Caenorhabditis elegans)
Secernentea Y48E1C.1 36
  • 8 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G35987 35
  • 45.57 (n)
  • 34.27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
Species with no ortholog for CAMKMT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAMKMT Gene

Gene Tree for CAMKMT (if available)
Gene Tree for CAMKMT (if available)

Paralogs for CAMKMT Gene

(1) SIMAP similar genes for CAMKMT Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CAMKMT: view

No data available for Paralogs for CAMKMT Gene

Variants for CAMKMT Gene

Sequence variations from dbSNP and Humsavar for CAMKMT Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs343935 -- 44,763,961(+) TTCCA(C/T)TATTC intron-variant
rs343936 -- 44,765,411(+) ACCAC(C/T)CTTCA intron-variant
rs343937 -- 44,766,403(+) AAAAT(A/G)TGTGA intron-variant
rs343938 -- 44,721,169(-) GTGGA(C/T)ATTTT intron-variant
rs343940 -- 44,761,798(+) GTGTG(G/T)GTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAMKMT Gene

Variant ID Type Subtype PubMed ID
nsv873986 CNV Gain 21882294
nsv833947 CNV Gain 17160897
esv2671323 CNV Deletion 23128226
esv2720003 CNV Deletion 23290073
esv2253758 CNV Deletion 18987734
esv2720004 CNV Deletion 23290073
nsv214031 CNV Loss 16902084
dgv4110n71 CNV Loss 21882294
nsv522689 CNV Loss 19592680
nsv873989 CNV Loss 21882294
esv2480971 CNV Deletion 19546169
nsv511784 CNV Loss 21212237
nsv214988 CNV Loss 16902084
esv1306593 CNV Deletion 17803354
esv2657450 CNV Deletion 23128226
esv1206912 CNV Deletion 17803354
esv22809 CNV Loss 19812545
esv2662977 CNV Deletion 23128226
esv270639 CNV Insertion 20981092
esv273785 CNV Insertion 20981092
nsv441756 CNV CNV 18776908
nsv514066 CNV Loss 21397061
esv271057 CNV Insertion 20981092
nsv507010 CNV Insertion 20534489
esv2592933 CNV Deletion 19546169

Variation tolerance for CAMKMT Gene

Residual Variation Intolerance Score: 20.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.61% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CAMKMT Gene

Disorders for CAMKMT Gene

MalaCards: The human disease database

(6) MalaCards diseases for CAMKMT Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
atypical hypotonia-cystinuria syndrome
  • atypical hcs
2p21 microdeletion syndrome without cystinuria
  • del(2)(p21) without cystinuria
2p21 microdeletion syndrome
  • 2p21 deletion syndrome
hypotonia-cystinuria syndrome
  • hcs
  • csnu
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CAMKMT

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CAMKMT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAMKMT Gene

Publications for CAMKMT Gene

  1. Calmodulin methyltransferase is an evolutionarily conserved enzyme that trimethylates Lys-115 in calmodulin. (PMID: 20975703) Magnani R. … Houtz R.L. (Nat. Commun. 2010) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 3
  4. Further delineation of genotype-phenotype correlation in homozygous 2p21 deletion syndromes: first description of patients without cystinuria. (PMID: 23794250) Bartholdi D. … Rauch A. (Am. J. Med. Genet. A 2013) 3
  5. A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. (PMID: 24025145) Chung S. … Nakamura Y. (Breast Cancer Res. 2013) 3

Products for CAMKMT Gene

Sources for CAMKMT Gene