Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CAMKK2 Gene

protein-coding GIFtS: 67
GCID: GC12M121675

calcium/calmodulin-dependent protein kinase kinase 2, beta

Explore 15 diseases affiliated with
CAMKK2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Calcium/Calmodulin-Dependent Protein Kinase Kinase 2, Beta¹ ²		Calcium/Calmodulin-Dependent Protein Kinase Beta²
CAMKKB¹ ² ³		Calcium/Calmodulin-Dependent Protein Kinase Kinase 2²
CAMKK¹ ²		CAMKK Beta Protein²
KIAA0787¹ ³		EC 2.7.11.17³
CaM-Kinase Kinase 2² ³		Calcium/Calmodulin-Dependent Protein Kinase Kinase Beta³
CaM-Kinase Kinase Beta² ³		CaMKK 2³
CaM-KK 2² ³		CaMKK Beta³
CaM-KK Beta² ³		EC 2.7.11⁸
MGC15254¹

External Ids:	HGNC: 1470¹	Entrez Gene: 10645²	Ensembl: ENSG00000110931⁷	OMIM: 615002⁵	UniProtKB: Q96RR4³

Export aliases for CAMKK2 gene to outside databases

Previous GC identifers: GC12M120537 GC12M121255 GC12M121458 GC12M120087 GC12M120138 GC12M120159 GC12M118685

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CAMKK2:

The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent

protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase

cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate

AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling

cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse

formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified

isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. (provided by

RefSeq, Jul 2012)

UniProtKB/Swiss-Prot: KKCC2_HUMAN, Q96RR4

Function: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade

involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform

3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are

inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of

PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to

be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may

promote neurite elongation, while isoform 1 may promoter neurite branching

summary for CAMKK2:

Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second

messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through

autoinhibition. Increases in Ca2+ levels allows calmodulin to relieve this autoinhibition and activate the

kinase activity. There are two main classes of CaMKs; mulitfunctional CaMKs (CaMKK, CaMKI, CaMKII and

CaMKIV) which have multiple downstream targets and substrate-specific CaMKs (CaMKIII) which have only one

known downstream target. All CaMKs, with the exception of CaMKII, exist as monomers and most are expressed

ubiquitously. Some subtypes display specific distributions, for example, CaMKIVbeta is expressed exclusively

in cerebellar granule cells. CaMKs have numerous cellular functions and they influence processes as diverse

as gene transcription, cell survival, apoptosis, cytoskeletal re-organization and learning and memory.

Gene Wiki entry for CAMKK2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009775.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CAMKK2 gene promoter:
CREB deltaCREB
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CAMKK2 promoter sequence

Search SABiosciences Chromatin IP Primers for CAMKK2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAMKK2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.2 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24.2

CAMKK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAMKK2 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M121675: view genomic region (about GC identifiers)

Start:	121,675,495 bp from pter	End:	121,736,111 bp from pter
Size:	60,617 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KKCC2_HUMAN, Q96RR4 (See protein sequence)

Recommended Name: Calcium/calmodulin-dependent protein kinase kinase 2

Size: 588 amino acids; 64746 Da

Subunit: Interacts with calmodulin (By similarity)

Subcellular location: Nucleus (By similarity). Cytoplasm. Cell projection. Note=Predominantly nuclear in unstimulated

cells (By similarity). Found in the cytoplasm and neurites after forskolin induction

Sequence caution: Sequence=AAC72943.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=BAA34507.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAD38990.1;

Type=Miscellaneous discrepancy; Note=Intron retention;

1 PDB 3D structure from and Proteopedia for CAMKK2:

2ZV2 (3D)

Secondary accessions: A8K7Q7 O94883 Q8IUG2 Q8IUG3 Q8N3I4 Q8WY03 Q8WY04 Q8WY05 Q8WY06 Q96RP1 Q96RP2

Q96RR3 Q9BWE9 Q9UER3 Q9UES2 Q9Y5N2

Alternative splicing: 7 isoforms: Q96RR4-1 Q96RR4-2 Q96RR4-3 Q96RR4-4 Q96RR4-5 Q96RR4-6 Q96RR4-7 (Inactive. Does not activate CAMK1 and CAMK4)

Explore the universe of human proteins at neXtProt for CAMKK2: NX_Q96RR4

Post-translational modifications:

Autophosphorylated and phosphorylated by PKA. Each isoform may show a different pattern of phosphorylation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96RR4

4 DME Specific Peptides for CAMKK2 (Q96RR4)

DLITRML

GHIKIAD

GKGSYGVV

GTPAFMAPE

CAMKK2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (9 alternative transcripts):

NP_001257414.1 NP_001257415.1 NP_006540.3 NP_705719.2 NP_705720.1 NP_757363.1 NP_757364.1 NP_757365.1

NP_757380.1

ENSEMBL proteins:

ENSP00000376266 ENSP00000321230 ENSP00000445944 ENSP00000336634 ENSP00000312741

ENSP00000441352 ENSP00000388368 ENSP00000384600 ENSP00000384591 ENSP00000388273

ENSP00000376265 ENSP00000444894 ENSP00000445400

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): CAMKK2 OriGene Protein Over-expression Lysate: CAMKK2 OriGene Custom Protein Services for CAMKK2
	GenScript Custom Purified and Recombinant Proteins Services for CAMKK2
	Novus Biologicals CAMKK2 Proteins Novus Biologicals CAMKK2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CAMKK2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	TAS	11395482
GO:0005737	cytoplasm	IDA	--

CAMKK2 for ontologies About GeneDecksing

CAMKK2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CAMKK2
	Browse R&D Systems for Antibodies
	OriGene Antibodies: CAMKK2 OriGene Custom Antibody Services for CAMKK2
	GenScript Custom Superior Antibodies Services for CAMKK2
	Novus Biologicals CAMKK2 Antibodies
	Abcam antibodies for CAMKK2
	Uscn Antibodies for CAMKK2
	ThermoFisher Antibodies for CAMKK2

Assay Products for CAMKK2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CAMKK2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CAMKK2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CAMKK2 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR017441 Protein_kinase_ATP_BS

IPR002290 Ser/Thr_dual-sp_kinase_dom

IPR011009 Kinase-like_dom

IPR008271 Ser/Thr_kinase_AS

IPR000719 Prot_kinase_cat_dom

Graphical View of Domain Structure for InterPro Entry Q96RR4

ProtoNet protein and cluster: Q96RR4

UniProtKB/Swiss-Prot: KKCC2_HUMAN, Q96RR4

Domain: The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric

autoinhibition

Domain: The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates (By

similarity)

Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family

Similarity: Contains 1 protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: KKCC2_HUMAN, Q96RR4

Function: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade

involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform

3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are

inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of

PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to

be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may

promote neurite elongation, while isoform 1 may promoter neurite branching

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme regulation: Activated by Ca(2+)/calmodulin. Binding of calmodulin may relieve intrasteric autoinhibition.

Autophosphorylation does not alter activity or regulation by Ca(2+)/calmodulin. In part, activity is independent on

Ca(2+)/calmodulin (By similarity)

Induction: Isoform 1 is up-regulated by PKA pathway

Genatlas biochemistry entry for CAMKK2:

calcium/calmodulin-dependent protein kinase,kinase 2,beta,expressed as a flag-tagged protein in human non small cell

lung cancer

Enzyme Numbers (IUBMB): EC 2.7.11² EC 2.7.11.17¹

miRNA Products:		OriGene 3'-UTR Clone (see all 7): CAMKK2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAMKK2
		8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate CAMKK2 (see all 60):
		hsa-miR-3194-5p hsa-miR-411 hsa-miR-29a hsa-miR-25 hsa-miR-16-1* hsa-miR-30d hsa-miR-218 hsa-miR-342-3p

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAMKK2 (see all 7) OriGene shRNA RFP: CAMKK2 OriGene siRNA: CAMKK2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAMKK2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CAMKK2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAMKK2 (see all 9) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAMKK2 (see all 10) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 7): CAMKK2 (NM_006549)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAMKK2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMKK2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CAMKK2
		Search LifeMap BioReagents cell lines for CAMKK2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMKK2

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004674	protein serine/threonine kinase activity	--	--
GO:0004683	calmodulin-dependent protein kinase activity	IEA	--
GO:0004713	protein tyrosine kinase activity	TAS	11395482
GO:0005509	calcium ion binding	IDA	11395482
GO:0005516	calmodulin binding	TAS	11395482

CAMKK2 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for CAMKK2:

Decreased focal adhesion (FA)

Decreased number of cells in m

Increased cell death HMECs cel

Animal Models:
Mouse knock-outs for CAMKK2: Camkk2^tm1Tch Camkk2^tm1.1Arm Camkk2^tm1Kpg
6 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Camkk2):

adipose tissue	behavior/neurological	growth/size	homeostasis/metabolism	nervous system
no phenotypic analysis

CAMKK2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune response_Function of MEF2 in T lymphocytes

Immune response_Function of MEF2 in T lymphocytes

1.00

Immune response Function of MEF2 in T lymphocytes

0.90

Signal transduction Calcium signaling

Signal transduction Calcium signaling

1.00

Signal transduction_Calcium signaling

0.97

Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis

Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis

1.00

Development_Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis

0.97

Signal transduction_IP3 signaling

Signal transduction_IP3 signaling

1.00

Signal transduction IP3 signaling

0.92

AMPK signaling

AMPK signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

4 EMD Millipore Pathways for CAMKK2

	Signal transduction Calcium signaling
	Immune response Function of MEF2 in T lymphocytes
	Signal transduction IP3 signaling
	Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CAMKK2

	IP3 Pathway
	Dopamine-DARPP32 Feedback onto cAMP Pathway

4 GeneGo (Thomson Reuters) Pathways for CAMKK2

	Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
	Immune response Function of MEF2 in T lymphocytes
	Signal transduction Calcium signaling
	Signal transduction IP3 signaling

1 BioSystems Pathway for CAMKK2

AMPK signaling

1 Kegg Pathway (Kegg details for CAMKK2):

Adipocytokine signaling pathway

CAMKK2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CAMKK2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/475 Interacting proteins for CAMKK2 (Q96RR4³ ENSP00000312741⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 475)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RPL9	P32969³	I2D: score=1
RPL9P7	P32969³	I2D: score=1
RPL9P8	P32969³	I2D: score=1
RPL9P9	P32969³	I2D: score=1
CALM1	P62158³, ENSP00000349467⁴	I2D: score=5 STRING: ENSP00000349467

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000165	MAPK cascade	TAS	11395482
GO:0006468	protein phosphorylation	IDA	11395482
GO:0019722	calcium-mediated signaling	TAS	11395482
GO:0045859	regulation of protein kinase activity	TAS	11395482
GO:0045893	positive regulation of transcription, DNA-dependent	TAS	11395482

CAMKK2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CAMKK2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for CAMKK2

Compounds for CAMKK2 available from Tocris Bioscience About this table

Compound	Action	CAS #
STO-609 acetate	Selective CaM kinase kinase inhibitor	[52029-86-4]

3 HMDB Compounds for CAMKK2 About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Calcium	Ca (see all 2)	7440-70-2	--

6 Novoseek chemical compound relationships for CAMKK2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
calcium	53.9	39	9859994 (3), 19958286 (2), 16497986 (2), 9822657 (2) (see all 19)
atp	33.6	4	18687367 (3), 10770941 (1)
nmda	30.1	5	9859994 (2), 15689566 (1), 18184567 (1)
serine	24.1	1	9859994 (1)
forskolin	23.5	3	10187789 (1), 15469938 (1), 9195898 (1)
cyclic amp	8.19	1	15764842 (1)

Search CenterWatch for drugs/clinical trials and news about CAMKK2 / KKCC2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CAMKK2 gene (9 alternative transcripts):

NM_001270485.1 NM_001270486.1 NM_006549.3 NM_153499.2 NM_153500.1 NM_172214.2 NM_172215.2 NM_172216.1

NM_172226.2

Unigene Cluster for CAMKK2:

Calcium/calmodulin-dependent protein kinase kinase 2, beta

Hs.297343 [show with all ESTs]

Unigene Representative Sequence: NM_006549

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000392474 ENST00000347034 ENST00000538733 ENST00000337174(uc001tzt.3)

ENST00000324774(uc001tzu.3 uc001tzv.3 uc001tzw.3 uc001tzx.3 uc001tzy.3 uc001uaa.1)

ENST00000545538(uc001tzz.1) ENST00000412367 ENST00000404169(uc001uad.2)

ENST00000402834 ENST00000446440 ENST00000392473(uc001uab.3 uc001uac.3)

ENST00000535524 ENST00000542540 ENST00000539380 ENST00000543477 ENST00000544485

miRNA Products:		OriGene 3'-UTR Clone (see all 7): CAMKK2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAMKK2
		8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate CAMKK2 (see all 60):
		hsa-miR-3194-5p hsa-miR-411 hsa-miR-29a hsa-miR-25 hsa-miR-16-1* hsa-miR-30d hsa-miR-218 hsa-miR-342-3p

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAMKK2 (see all 7) OriGene shRNA RFP: CAMKK2 OriGene siRNA: CAMKK2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAMKK2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAMKK2 (see all 9) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAMKK2 (see all 10) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 7): CAMKK2 (NM_006549)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAMKK2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMKK2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CAMKK2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CAMKK2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAMKK2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAMKK2

Additional cDNA sequence:

AB018330.2 AB081336.1 AB081337.1 AF091074.1 AF101264.1 AF287630.1 AF287631.1 AF321385.1

AF321386.1 AF321387.1 AF321388.1 AF425668.1 AK024748.1 AK292072.1 AK300865.1 AK311473.1

AL834322.1 BC000318.2 BC026060.2

23 DOTS entries:

DT.100824426 DT.95150357 DT.95150349 DT.455652 DT.100824425 DT.100824423 DT.86846422 DT.95150335

DT.92446457 DT.121180026 DT.121180044 DT.100824430 DT.75101428 DT.95150362 DT.100824424 DT.121180053

DT.100824429 DT.121180024 DT.121180014 DT.121180045 DT.121180049 DT.91744128 DT.95150355

24/328 AceView cDNA sequences (see all 328):

AI815054 NM_172214 T31199 BE939864 AI656058 BF926869 AA491295 AI928437

W70128 AI184642 NM_172226 BM718658 AA922204 CB152090 AA678930 BI225425

CB154461 NM_006549 AI972885 CA431335 NM_172215 BM908574 BM547242 T33239

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for CAMKK2 (see all 16) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7a	·	7b	·	7c	·	7d	·	7e	^	8a	·	8b	^	9	^	10	^	11a	·	11b	^	12	^	13a	·	13b	·	13c	·	13d	^
SP1:
SP2:
SP3:
SP4:
SP5:													-		-						-		-		-		-		-								-		-

ExUns:	14	^	15	^	16a	·	16b	·	16c	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^	24a	·	24b	^	25
SP1:																							-		-		-
SP2:
SP3:																	-				-		-
SP4:																	-						-
SP5:

ECgene alternative splicing isoforms for CAMKK2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CAMKK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACTTAAGAG

About this image

CAMKK2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Head Mesenchyme

Branchial Arch 1

Cranial Neural Crest Cells

Neural Crest

Heart

Endocardium

Endocardial Tube Cells

Endocardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

See CAMKK2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CAMKK2

SOURCE GeneReport for Unigene cluster: Hs.297343

UniProtKB/Swiss-Prot: KKCC2_HUMAN, Q96RR4

Tissue specificity: Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen,

prostate, thyroid and leukocytes. The lowest level is in lung

SABiosciences Custom PCR Arrays for CAMKK2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CAMKK2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CAMKK2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAMKK2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAMKK2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMKK2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAMKK2 gene from 6/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CAMKK2¹	calcium/calmodulin-dependent protein kinase kinase more	76.41(n) 80.12(a)		396405 XM_415134.2 XP_415134.2
zebrafish (Danio rerio)	Actinopterygii	zgc:194737¹	zgc:194737	67.08(n) 69.63(a)		100170786 NM_001130625.1 NP_001124097.1
fruit fly (Drosophila melanogaster)	Insecta	CG17698^{1 , 3}	protein amino acid phosphorylation protein serine/threonine more³ CG17698¹	54(a)³ 54.05(n)¹ 57.03(a)¹		4379919¹ NM_001043169.1¹ NP_001036634.1¹
worm (Caenorhabditis elegans)	Secernentea	ckk-1³	--	56(a)		III(5723519-5725386) --
thale cress (Arabidopsis thaliana)	eudicotyledons	GRIK2⁶ ATSNAK2⁶	geminivirus rep interacting kinase 2 calcium/calmodulin-dependent protein kinase kinase...	30(a) 29(a)	many ↔ many many ↔ many	5(24339229-24342590) 3(16570478-16573762)
rice (Oryza sativa)	Liliopsida	--	CAMK_KIN1/SNF1/Nim1_like.18 - CAMK includes calciu...	27(a)	1 → many	3(28701639-28709268)

ENSEMBL Gene Tree for CAMKK2 (if available)
TreeFam Gene Tree for CAMKK2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CAMKK2 gene

CAMKK1²

18/38 SIMAP similar genes for CAMKK2 using alignment to 6 protein entries: KKCC2_HUMAN (see all proteins) (see all similar genes):

CAMKK1 STK38L MAPK8 RPS6KA1 STK11 BRSK2

FGFR1 MARK4 RPS6KA2 CAMK1 FLT4 MAPK14

BRAF CDK7 HUNK MAP4K5 PHKG1 TXK

CAMKK2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11609877^1,2	H	--	121675130(+)	`tttttA/Taattt`	7	--	ds500¹ int¹		0	--	--	--	--
rs11611762^1,2	H	--	121675132(+)	`ttttaA/Tttttt`	7	--	int¹ ds500¹		0	--	--	--	--
rs34283701^1,2	C,	--	121675150(+)	`TTTTT-/AAGAGA`	7	--	int¹ ds500¹		0	--	--	--	--
rs79886121^1,2	C	--	121675150(+)	`TTTTTA/TAGAGA`	7	--	ds500¹ int¹		0	--	--	--	--
rs7136106^1,2	C,A,	--	121675268(+)	`cggccG/Agcacc`	7	--	ds500¹ int¹		3		NA WA	240
rs139409167^1,2		--	121675289(+)	`ACCCAC/GTCACA`	7	--	ds500¹ int¹		0	--	--	--	--
rs10849861^1,2	C,F,A,H,	--	121675307(+)	`CTGGCG/ACTACT`	7	--	ds500¹ int¹		8		NS EA CSA WA NA	750
rs116433104^1,2	C,F,	--	121675479(+)	`ACCTCC/TCCAAG`	7	--	ds500¹ int¹		1		WA	118
rs1653586^1,2	C,F,O,A,H,	--	121675575(+)	`TAGTTG/TTCTCT`	7	--	ut3¹ ese³		29		MN EA NA NS CSA WA	3168
rs11308^1,2	C,	--	121675684(-)	`TGCCCG/AATGCT`	7	--	ut3¹ ese³		1		MN	184

HapMap Linkage Disequilibrium report for CAMKK2 (121675495 - 121736111 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CAMKK2: --
Human Gene Mutation Database (HGMD): CAMKK2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CAMKK2

DNA2.0 Custom Variant and Variant Library Synthesis for CAMKK2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CAMKK2 for disorders           About GeneDecksing

OMIM gene information: 615002    OMIM disorders: --

15 diseases for CAMKK2:    About MalaCards

bipolar affective disorder amyotrophic lateral sclerosis lateral sclerosis mantle cell lymphoma

anxiety disorder neuronitis cervical cancer cervicitis

lung cancer breast cancer hypoxia schizophrenia

thyroiditis malaria prostatitis

Human Genome Epidemiology (HuGE) Navigator: CAMKK2 (4 documents)

Export disorders for CAMKK2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CAMKK2 gene, integrated from 9 sources (see all 102):
(articles sorted by number of sources associating them with CAMKK2)

Utopia: connect your pdf to the dynamic
world of online information

Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase. (PubMed id 9662074)^{1, 2, 3, 9} Hsu L.-S.... Chen J.-Y. (1998)
Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity. (PubMed id 11395482)^{1, 2, 9} Hsu L.-S.... Chen J.-Y. (2001)
Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta. (PubMed id 9822657)^{1, 2, 9} Anderson K.A.... Means A.R. (1998)
Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells. (PubMed id 12935886)^{1, 2, 9} Ishikawa Y....Kobayashi R. (2003)
Differential effects of PKA-controlled CaMKK2 variants on neuronal differentiation. (PubMed id 21957496)^{1, 2} Cao W....Xie J. (2011)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{1, 2} Nakajima D.... Nagase T. (2002)
Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)^{1, 2} Nagase T.... Ohara O. (1998)
Inhibition of the Ca2+/calmodulin-dependent protein kinase I cascade by cAMP-dependent protein kinase. (PubMed id 10187789)^{1, 9} Matsushita M. and Nairn A.C. (1999)
Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders. (PubMed id 17197037)^{1, 9} Erhardt A....Holsboer F. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10645	HGNC: 1470	AceView: CAMKK2	Ensembl:ENSG00000110931	euGenes: HUgn10645
ECgene: CAMKK2	Kegg: 10645	H-InvDB: CAMKK2

(According to HUGE)
About This Section

HUGE: KIAA0787

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CAMKK2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CAMKK2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CAMKK2 gene:
Search GeneIP for patents involving CAMKK2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Small Molecules at EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of CAMKK2
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for CAMKK2		OriGene shRNA RFP for CAMKK2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAMKK2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CAMKK2
	OriGene Protein Over-expression Lysate for CAMKK2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CAMKK2		OriGene 3'-UTR Clone for CAMKK2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAMKK2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAMKK2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for CAMKK2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CAMKK2		OriGene Custom Protein Services for CAMKK2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CAMKK2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CAMKK2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAMKK2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAMKK2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAMKK2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAMKK2

	GenScript Custom Purified and Recombinant Proteins Services for CAMKK2		GenScript cDNA clones with any tag delivered in your preferred vector for CAMKK2
	GenScript Custom Assay Services for CAMKK2		GenScript Custom Superior Antibodies Services for CAMKK2
	GenScript Custom overexpressing Cell Line Services for CAMKK2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in CAMKK2 promoter
	Search Chromatin IP Primers for CAMKK2
	RT² qPCR Primer Assay in human, mouse, rat CAMKK2
	GNC Network for CAMKK2
	SABiosciences PCR Arrays including human, mouse, rat CAMKK2

Tocris compounds for CAMKK2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

	Drugs for CAMKK2
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CAMKK2 antibodies
	CAMKK2 proteins
	CAMKK2 lysates

	Antibodies for CAMKK2
	See all of Abcam's Antibodies, Kits and Proteins for CAMKK2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

CAMKK2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for CAMKK2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMKK2

	Browse SwitchGear 3'UTR luciferase reporter plasmids for CAMKK2
	SwitchGear Promoter luciferase reporter plasmids for CAMKK2

ThermoFisher Antibodies for CAMKK2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMKK2

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CAMKK2 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

CAMKK2 Gene

calcium/calmodulin-dependent protein kinase kinase 2, beta

Aliases
for CAMKK2 gene

Summaries
for CAMKK2 gene

Genomic Views
for CAMKK2 gene

Proteins
for CAMKK2 gene

Protein Domains /
Families
for CAMKK2 gene

Function
for CAMKK2 gene

Pathways & Interactions
for CAMKK2 gene

Drugs & Compounds
for CAMKK2 gene

Transcripts
for CAMKK2 gene

Expression
for CAMKK2 gene

Orthologs
for CAMKK2 gene

Paralogs
for CAMKK2 gene

Genomic Variants
for CAMKK2 gene

Disorders / Diseases
for CAMKK2 gene

Publications
for CAMKK2 gene

External Searches for CAMKK2 gene

Genome Databases showing CAMKK2 gene

Other Databases showing CAMKK2 gene

Specialized Databases showing CAMKK2 gene

Intellectual Property
for CAMKK2 gene

Products
for CAMKK2 gene

View Random Gene

Advanced Search

Export list of displayed genes

CAMKK2 Gene

calcium/calmodulin-dependent protein kinase kinase 2, beta

Aliasesfor CAMKK2 gene

Summariesfor CAMKK2 gene

Genomic Viewsfor CAMKK2 gene

Proteinsfor CAMKK2 gene

Protein Domains /Familiesfor CAMKK2 gene

Functionfor CAMKK2 gene

Pathways & Interactionsfor CAMKK2 gene

Drugs & Compoundsfor CAMKK2 gene

Transcriptsfor CAMKK2 gene

Expression for CAMKK2 gene

Orthologsfor CAMKK2 gene

Paralogsfor CAMKK2 gene

Genomic Variantsfor CAMKK2 gene

Disorders / Diseasesfor CAMKK2 gene

Publicationsfor CAMKK2 gene

External Searches for CAMKK2 gene

Genome Databases showing CAMKK2 gene

Other Databases showing CAMKK2 gene

Specialized Databases showing CAMKK2 gene

Intellectual Propertyfor CAMKK2 gene

Productsfor CAMKK2 gene

View Random Gene

Aliases
for CAMKK2 gene

Summaries
for CAMKK2 gene

Genomic Views
for CAMKK2 gene

Proteins
for CAMKK2 gene

Protein Domains /
Families
for CAMKK2 gene

Function
for CAMKK2 gene

Pathways & Interactions
for CAMKK2 gene

Drugs & Compounds
for CAMKK2 gene

Transcripts
for CAMKK2 gene

Expression
for CAMKK2 gene

Orthologs
for CAMKK2 gene

Paralogs
for CAMKK2 gene

Genomic Variants
for CAMKK2 gene

Disorders / Diseases
for CAMKK2 gene

Publications
for CAMKK2 gene

Intellectual Property
for CAMKK2 gene

Products
for CAMKK2 gene