Aliases for CAMKK2 Gene
Aliases for CAMKK2 Gene
- Calcium/Calmodulin Dependent Protein Kinase Kinase 2 2 3 5
- Calcium/Calmodulin-Dependent Protein Kinase Kinase 2, Beta 2 3
- Calcium/Calmodulin-Dependent Protein Kinase Kinase Beta 2 4
- CaM-Kinase Kinase Beta 3 4
- CaM-Kinase Kinase 2 3 4
- CaM-KK Beta 3 4
- CaM-KK 2 3 4
- CAMKKB 3 4
- Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 3
External Ids for CAMKK2 Gene
- HGNC: 1470
- Entrez Gene: 10645
- Ensembl: ENSG00000110931
- OMIM: 615002
- UniProtKB: Q96RR4
Previous GeneCards Identifiers for CAMKK2 Gene
- GC12M120537
- GC12M121458
- GC12M120087
- GC12M120138
- GC12M120159
- GC12M121675
- GC12M118685
Summaries for CAMKK2 Gene
-
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012]
GeneCards Summary for CAMKK2 Gene
CAMKK2 (Calcium/Calmodulin Dependent Protein Kinase Kinase 2) is a Protein Coding gene. Among its related pathways are Development Angiotensin activation of ERK and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include calcium ion binding and protein kinase activity. An important paralog of this gene is CAMKK1.
UniProtKB/Swiss-Prot for CAMKK2 Gene
-
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.
-
Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through autoinhibition, which can be relieved by increases in Ca2+ levels.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMKK2 Gene
Genomics for CAMKK2 Gene
Regulatory Elements for CAMKK2 Gene
Enhancers for CAMKK2 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CAMKK2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CAMKK2 gene promoter:
Regulatory Element Products
Genomic Location for CAMKK2 Gene
- Chromosome:
- 12
- Start:
- 121,237,691 bp from pter
- End:
- 121,298,308 bp from pter
- Size:
- 60,618 bases
- Orientation:
- Minus strand
Genomic View for CAMKK2 Gene
Genes around CAMKK2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q24.31 by Ensembl
- 12q24.31 by Entrez Gene
- 12q24.31 by HGNC
CAMKK2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CAMKK2 Gene
Proteins for CAMKK2 Gene
-
Protein details for CAMKK2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96RR4-KKCC2_HUMAN
- Recommended name:
- Calcium/calmodulin-dependent protein kinase kinase 2
- Protein Accession:
- Q96RR4
- A8K7Q7
- O94883
- Q8IUG2
- Q8IUG3
- Q8N3I4
- Q8WY03
- Q8WY04
- Q8WY05
- Q8WY06
- Q96RP1
- Q96RP2
- Q96RR3
- Q9BWE9
- Q9UER3
- Q9UES2
- Q9Y5N2
Protein attributes for CAMKK2 Gene
- Size:
- 588 amino acids
- Molecular mass:
- 64746 Da
- Quaternary structure:
-
- Interacts with calmodulin.
- SequenceCaution:
-
- Sequence=AAC72943.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA34507.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD38990.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
Protein Expression for CAMKK2 Gene
Selected DME Specific Peptides for CAMKK2 Gene
- Q96RR4:
-
- DLITRML
- GTPAFMAPE
- GHIKIAD
- GKGSYGVV
Post-translational modifications for CAMKK2 Gene
- Autophosphorylated and phosphorylated by PKA. Each isoform may show a different pattern of phosphorylation.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for CAMKK2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- NP_001257414.1
- NP_001257415.1
- NP_006540.3
- NP_705719.2
- NP_705720.1
- NP_757363.1
- NP_757364.1
- NP_757365.1
- NP_757380.1
- XP_005253879.1
- XP_005253880.1
- XP_005253881.1
- XP_011536065.1
- XP_011536066.1
- XP_016874183.1
- XP_016874184.1
- XP_016874185.1
- XP_016874186.1
- XP_016874187.1
- XP_016874188.1
- XP_016874189.1
- XP_016874190.1
- XP_016874191.1
- XP_016874192.1
- XP_016874193.1
- XP_016874194.1
- XP_016874195.1
- XP_016874196.1
- XP_016874197.1
- XP_016874198.1
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CAMKK2
- Cell Signaling Technology (CST) Antibodies for CAMKK2 (CAMKK2)
-
Custom Antibody ServicesOriGene Antibodies for CAMKK2
- Novus Biologicals Antibodies for CAMKK2
- Invitrogen Antibodies for CAMKK2
- antibodies-online Antibodies for CAMKK2: See all 97
- GeneTex CAMKK2 antibody for CAMKK2
-
Santa Cruz Biotechnology (SCBT) Antibodies for CAMKK2
Protein Products
- EMD Millipore Purified and/or Recombinant CAMKK2 Protein
- Search Origene for MassSpec and Protein Over-expression Lysates for CAMKK2
- Origene Custom Protein Services for CAMKK2
- antibodies-online Proteins for CAMKK2: See all 9
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CAMKK2
Assay Products
- antibodies-online Kits for CAMKK2: See all 11
Domains & Families for CAMKK2 Gene
Gene Families for CAMKK2 Gene
Protein Domains for CAMKK2 Gene
Suggested Antigen Peptide Sequences for CAMKK2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96RR4UniProtKB/Swiss-Prot:
KKCC2_HUMAN :- The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition.
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
- Domain:
-
- The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition.
- The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates.
- Family:
-
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Function for CAMKK2 Gene
Molecular function for CAMKK2 Gene
- GENATLAS Biochemistry:
- calcium/calmodulin-dependent protein kinase,kinase 2,beta,expressed as a flag-tagged protein in human non small cell lung cancer
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by Ca(2+)/calmodulin. Binding of calmodulin may relieve intrasteric autoinhibition. Autophosphorylation does not alter activity or regulation by Ca(2+)/calmodulin. In part, activity is independent on Ca(2+)/calmodulin (By similarity).
- UniProtKB/Swiss-Prot Function:
- Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.
- UniProtKB/Swiss-Prot Induction:
- Isoform 1 is up-regulated by PKA pathway.
Enzyme Numbers (IUBMB) for CAMKK2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IEA | -- |
| GO:0004683 | calmodulin-dependent protein kinase activity | IBA | -- |
| GO:0004713 | protein tyrosine kinase activity | TAS | 11395482 |
Phenotypes for CAMKK2 Gene
- MGI mutant phenotypes for CAMKK2:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for CAMKK2:
-
- Increased vaccinia virus (VACV) infection
- Decreased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
- Transferrin accumulation in the perinuclear area
- Increased shRNA abundance (Z-score > 2)
- Decreased viability
- Decreased vesicular stomatitis virus (VSV) infection
- Decreased shRNA abundance (Z-score < -2)
- Decreased HIV-LTR-beta-galactosidase protein expression
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Decreased cell migration
- Increased cell death HMECs cells
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Decreased cell proliferation
Animal Models for CAMKK2 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for CAMKK2
- Cyagen custom Knockout/knockin (KOKI) mouse models for CAMKK2
-
- Search ViGene Biosciences for CAMKK2
CRISPR Products
-
OriGene CRISPR knockouts for CAMKK2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CAMKK2
- GenScript: Design CRISPR guide RNA sequences for CAMKK2
miRNA for CAMKK2 Gene
- miRTarBase miRNAs that target CAMKK2
-
- hsa-mir-103a-3p (MIRT027179)
- hsa-mir-16-5p (MIRT031851)
- hsa-mir-185-5p (MIRT045326)
- hsa-mir-100-5p (MIRT048541)
- hsa-mir-147a (MIRT688850)
- hsa-mir-6818-5p (MIRT688851)
- hsa-mir-4309 (MIRT688852)
- hsa-mir-3198 (MIRT688853)
- hsa-mir-664b-3p (MIRT688854)
- hsa-mir-579-3p (MIRT688855)
- hsa-mir-5100 (MIRT688856)
- hsa-mir-644a (MIRT688857)
- hsa-mir-3911 (MIRT688858)
- hsa-mir-7847-3p (MIRT688859)
- hsa-mir-8078 (MIRT688860)
- hsa-mir-4294 (MIRT688861)
- hsa-mir-1289 (MIRT688862)
- hsa-mir-3664-3p (MIRT688863)
- hsa-mir-4330 (MIRT688864)
- hsa-mir-1288-5p (MIRT688865)
- hsa-mir-9500 (MIRT688866)
- hsa-mir-6822-5p (MIRT688867)
- hsa-mir-6750-5p (MIRT688868)
- hsa-mir-5584-5p (MIRT688869)
- hsa-mir-6854-5p (MIRT688870)
miRNA Products
- Search ViGene Biosciences for CAMKK2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CAMKK2
- Browse OriGene Inhibitory RNA Products For CAMKK2
Clone Products
-
OriGene ORF clones in human for CAMKK2
- RC234502
- RG234502
- RC234426
- RG234426
- RC222692
- RC222692L1
- RC222692L2
- RG222692
- RC219152
- RC219152L1
- RC219152L2
- RG219152
- RC213882
- RC213882L1
- RC213882L2
- RG213882
- RC215581
- RC215581L1
- RC215581L2
- RG215581
- RC219748
- RC219748L1
- RC219748L2
- RG219748
- RC219809
- RC219809L1
- RC219809L2
- RG219809
- RC203468
- RC203468L1
- RC203468L2
- RG203468
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CAMKK2
- VectorBuilder custom plasmid, inducible vectors for CAMKK2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CAMKK2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CAMKK2
Flow Cytometry Products
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAMKK2 Gene
Localization for CAMKK2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CAMKK2 Gene
- Nucleus. Cytoplasm. Cell projection. Note=Predominantly nuclear in unstimulated cells (By similarity). Found in the cytoplasm and neurites after forskolin induction. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | TAS,IMP | 11395482 |
| GO:0005634 | nucleus | IEA,IBA | -- |
| GO:0005737 | cytoplasm | IEA,IBA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0042995 | cell projection | IEA | -- |
Pathways & Interactions for CAMKK2 Gene
Pathways by source for CAMKK2 Gene
2 Cell Signaling Technology pathways for CAMKK2 Gene
1 BioSystems pathway for CAMKK2 Gene
6 KEGG pathways for CAMKK2 Gene
4 GeneGo (Thomson Reuters) pathways for CAMKK2 Gene
2 Qiagen pathways for CAMKK2 Gene
Interacting Proteins for CAMKK2 Gene
SIGNOR curated interactions for CAMKK2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | 11395482 |
| GO:0001934 | positive regulation of protein phosphorylation | IMP | 26103054 |
| GO:0006468 | protein phosphorylation | IDA | 11395482 |
| GO:0016310 | phosphorylation | IEA | -- |
| GO:0018105 | peptidyl-serine phosphorylation | IBA | -- |
Drugs & Compounds for CAMKK2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Adenosine triphosphate | Approved | Nutra | 0 | |||
| calcium | Nutra | 0 | ||||
| A 484954 | Pharma | EEF2K Inhibitor, CaM kinase III (eEF-2 kinase) inhibitor | 0 | |||
| KN-93 Phosphate | Pharma | CaM kinase II inhibitor, water soluble and cell permeable, CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278). | 0 | |||
| STO-609 acetate | Pharma | Selective CaM kinase kinase inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
||
| Autocamtide-2-related inhibitory peptide, myristoylated |
|
201422-04-0 |
|
|
||
| KN 93 |
|
139298-40-1 |
|
|
(5) Tocris Compounds for CAMKK2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| A 484954 | CaM kinase III (eEF-2 kinase) inhibitor | 142557-61-7 |
| Autocamtide-2-related inhibitory peptide, myristoylated | CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptide | 201422-04-0 |
| KN 93 | CaM kinase II inhibitor; also K+ channel blocker (KV) | 139298-40-1 |
| KN 93 phosphate | CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278). | 1188890-41-6 |
| STO-609 acetate | Selective CaM kinase kinase inhibitor | 1173022-21-3 |
Transcripts for CAMKK2 Gene
mRNA/cDNA for CAMKK2 Gene
- (30) REFSEQ mRNAs :
- (19) Additional mRNA sequences :
- (328) Selected AceView cDNA sequences:
- (16) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CAMKK2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CAMKK2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CAMKK2
- GenScript: Design CRISPR guide RNA sequences for CAMKK2
miRNA Products
- Search ViGene Biosciences for CAMKK2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CAMKK2
- Browse OriGene Inhibitory RNA Products For CAMKK2
Clone Products
-
OriGene ORF clones in human for CAMKK2
- RC234502
- RG234502
- RC234426
- RG234426
- RC222692
- RC222692L1
- RC222692L2
- RG222692
- RC219152
- RC219152L1
- RC219152L2
- RG219152
- RC213882
- RC213882L1
- RC213882L2
- RG213882
- RC215581
- RC215581L1
- RC215581L2
- RG215581
- RC219748
- RC219748L1
- RC219748L2
- RG219748
- RC219809
- RC219809L1
- RC219809L2
- RG219809
- RC203468
- RC203468L1
- RC203468L2
- RG203468
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CAMKK2
- VectorBuilder custom plasmid, inducible vectors for CAMKK2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CAMKK2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | · | 13c | · | 13d | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - |
| ExUns: | 14 | ^ | 15 | ^ | 16a | · | 16b | · | 16c | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24a | · | 24b | ^ | 25 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||
| SP10: | - | - | |||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||||
| SP15: | |||||||||||||||||||||||||||||
| SP16: |
Expression for CAMKK2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Brain (Nervous System)
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
- Blood (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for CAMKK2 Gene
This gene is overexpressed in Brain - Cerebellar Hemisphere (x7.3) and Brain - Cerebellum (x7.2).
This gene is overexpressed in Lung (33.9) and Amniocyte (18.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CAMKK2 Gene
NURSA nuclear receptor signaling pathways regulating expression of CAMKK2 Gene:
CAMKK2SOURCE GeneReport for Unigene cluster for CAMKK2 Gene:
Hs.297343mRNA Expression by UniProt/SwissProt for CAMKK2 Gene:
Q96RR4-KKCC2_HUMAN
Tissue specificity:
Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung.
Evidence on tissue expression from TISSUES for CAMKK2 Gene
- Nervous system(5)
- Liver(4.3)
- Stomach(4.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for CAMKK2
-
OriGene qPCR primer pairs for CAMKK2
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CAMKK2 Gene
Orthologs for CAMKK2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CAMKK2 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | CAMKK2 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CAMKK2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CAMKK2 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Camkk2 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Camkk2 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | CAMKK2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CAMKK2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
ManyToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | camkk2 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | CAMKK2 35 |
|
OneToOne | |
| zgc:194737 34 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002250 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG17698 36 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | ckk-1 36 34 35 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TOS3 37 35 |
|
||
| SAK1 35 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for CAMKK2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CAMKK2 Gene
(38) SIMAP similar genes for CAMKK2 Gene using alignment to 5 proteins:
Variants for CAMKK2 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_040611 | A lung neuroendocrine carcinoma sample | ||||
| VAR_040612 | A colorectal adenocarcinoma sample | ||||
| rs1000002040 | -- | 121,293,020(+) | CCTGT(A/G)ATCCC | intron-variant | |
| rs1000022043 | -- | 121,289,807(+) | ACAAT(C/T)GCCTG | intron-variant | |
| rs1000047916 | -- | 121,248,896(+) | GGGGC(A/G)GAAAC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1008629 | CNV | insertion | 20482838 |
| esv2660506 | CNV | deletion | 23128226 |
| esv2746484 | CNV | deletion | 23290073 |
| esv2746485 | CNV | deletion | 23290073 |
| esv3336861 | CNV | duplication | 20981092 |
| esv3630945 | CNV | loss | 21293372 |
| nsv1048801 | CNV | gain | 25217958 |
| nsv1054878 | CNV | gain | 25217958 |
| nsv455731 | CNV | loss | 19166990 |
| nsv513372 | CNV | insertion | 21212237 |
| nsv521928 | CNV | gain | 19592680 |
| nsv560454 | CNV | loss | 21841781 |
| nsv560455 | CNV | gain | 21841781 |
| nsv560456 | CNV | loss | 21841781 |
| nsv952494 | CNV | deletion | 24416366 |
| nsv983372 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
44.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.62;
89.08% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CAMKK2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMKK2 Gene
Disorders for CAMKK2 Gene
Relevant External Links for CAMKK2
No disorders were found for CAMKK2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAMKK2 Gene
Publications for CAMKK2 Gene
- Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase. (PMID: 9662074) Hsu L.-S. … Chen J.-Y. (J. Biomed. Sci. 1998) 2 3 4 22 64
- Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders. (PMID: 17197037) Erhardt A. … Holsboer F. (J Affect Disord 2007) 3 22 46 64
- Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells. (PMID: 12935886) Ishikawa Y. … Kobayashi R. (FEBS Lett. 2003) 3 4 22 64
- Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity. (PMID: 11395482) Hsu L.-S. … Chen J.-Y. (J. Biol. Chem. 2001) 3 4 22 64
- Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta. (PMID: 9822657) Anderson K.A. … Means A.R. (J. Biol. Chem. 1998) 3 4 22 64
Products for CAMKK2 Gene
- Browse Small Molecules at EMD Millipore
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CAMKK2
- EMD Millipore Purified and/or Recombinant CAMKK2 Protein
- Browse Kits and Assays available from EMD Millipore
- EMD Millipore genomic analysis products
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
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- Browse Cell Selection and Detection Kits
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- Browse ELISpot/FluoroSpot Kits and Development Modules
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- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CAMKK2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CAMKK2
- Origene Custom Protein Services for CAMKK2
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CAMKK2
- Browse OriGene Inhibitory RNA Products For CAMKK2
- OriGene qPCR primer pairs and template standards for CAMKK2
- OriGene qPCR primer pairs for CAMKK2
- OriGene CRISPR knockouts for CAMKK2
- OriGene ORF clones in human for CAMKK2
- RC234502
- RG234502
- RC234426
- RG234426
- RC222692
- RC222692L1
- RC222692L2
- RG222692
- RC219152
- RC219152L1
- RC219152L2
- RG219152
- RC213882
- RC213882L1
- RC213882L2
- RG213882
- RC215581
- RC215581L1
- RC215581L2
- RG215581
- RC219748
- RC219748L1
- RC219748L2
- RG219748
- RC219809
- RC219809L1
- RC219809L2
- RG219809
- RC203468
- RC203468L1
- RC203468L2
- RG203468
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CAMKK2
- GenScript: Next-day shipping cDNA ORF clone for CAMKK2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CAMKK2
- GenScript Custom Assay Services for CAMKK2
- GenScript Custom overexpressing Cell Line Services for CAMKK2
- GenScript: Design CRISPR guide RNA sequences for CAMKK2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CAMKK2
- Cell Signaling Technology (CST) Antibodies for CAMKK2 (CAMKK2)
- Search for Antibodies & Assays
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for CAMKK2
- Novus Biologicals proteins and lysates for CAMKK2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Taconic Biosciences Mouse Models for CAMKK2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Addgene plasmids for CAMKK2
- antibodies-online Antibodies for CAMKK2: See all 97
- antibodies-online Kits for CAMKK2: See all 11
- antibodies-online Proteins for CAMKK2: See all 9
- Search antibodies-online for peptides
- GeneTex CAMKK2 antibody for CAMKK2
- Search GeneTex for Proteins for CAMKK2
- Search ViGene Biosciences for CAMKK2
- Santa Cruz Biotechnology (SCBT) Antibodies for CAMKK2
- Search Santa Cruz Biotechnology (SCBT) for CAMKK2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CAMKK2
- Horizon Cell Lines for CAMKK2
- Cyagen custom Knockout/knockin (KOKI) mouse models for CAMKK2
- VectorBuilder custom plasmid, inducible vectors for CAMKK2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CAMKK2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CAMKK2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer