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CAMKK2 Gene

protein-coding GIFtS: 65

GC12M120138

calcium/calmodulin-dependent protein kinase kinase 2, beta
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CAMKK ^¹, ²
CAMKKB ^¹, ², ³
EC 2.7.11.17 ^³
KIAA0787 ^¹, ², ³
MGC15254 ^¹, ²

Descriptions
CAMKK beta protein ^²
CaM-KK beta ^³
CaM-kinase kinase beta ^³
CaMKK beta ^³
Calcium/calmodulin-dependent protein kinase kinase beta ^³
calcium/calmodulin-dependent protein kinase beta ^²
calcium/calmodulin-dependent protein kinase kinase 2 beta ^²
calcium/calmodulin-dependent protein kinase kinase 2, beta ^²

External Ids
HGNC: 1470¹
Entrez Gene: 10645²
UniProtKB: Q96RR4³
Ensembl: ENSG00000110931⁷

Search outside databases for aliases for CAMKK2 gene

Previous GC identifers: GC12M120537 GC12M121255 GC12M121458 GC12M120087

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CAMKK2:

The product of this gene belongs to the Serine/Threonine protein kinase family, and to the

Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the

calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1

and CaMK4. Seven transcript variants encoding six distinct isoforms have been identified for this

gene. Additional splice variants have been described but their full-length nature has not been

determined. The identified isoforms exhibit a distinct ability to undergo autophosphorylation and

to phosphorylate the downstream kinases. [provided by RefSeq]

UniProtKB/Swiss-Prot: KKCC2_HUMAN, Q96RR4

Function: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered

signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3

phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6

lacking part of the calmodulin-binding domain are inactive. Seems to be involved in hippocampal

activation of CREB1 (By similarity)

Gene Wiki entry for CAMKK2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CAMKK2 gene

Entrez Gene cytogenetic band: 12q24.2 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24.2

CAMKK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M120138: (about GC identifiers)

Start:	120,159,878 bp from pter
End:	120,220,494 bp from pter
Size:	60,617 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000012.10 NT_009775.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: KKCC2_HUMAN, Q96RR4 (See protein sequence)

Recommended Name: Calcium/calmodulin-dependent protein kinase kinase 2

Size: 588 amino acids; 64732 Da

Subunit: Interacts with calmodulin (By similarity)

Subcellular location: Cytoplasm (By similarity)

Sequence caution: Sequence=CAD38990.1; Type=Miscellaneous discrepancy; Note=Intron retention;

Secondary accessions: A8K7Q7 O94883 Q8IUG2 Q8IUG3 Q8N3I4 Q8WY03 Q8WY04 Q8WY05 Q8WY06 Q96RP1 Q96RP2

Q96RR3 Q9BWE9 Q9UER3 Q9UES2 Q9Y5N2

Alternative splicing: 7 isoforms: Q96RR4-1 Q96RR4-2 Q96RR4-3 Q96RR4-4 Q96RR4-5 Q96RR4-6 Q96RR4-7

Post-translational modifications:

Autophosphorylated (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (7 alternative transcripts):

NP_006540.3 NP_705719.2 NP_705720.1 NP_757363.1 NP_757364.1 NP_757365.1 NP_757380.1

ENSEMBL proteins:

ENSP00000312741 ENSP00000321230 ENSP00000384591 ENSP00000384600 ENSP00000336634 ENSP00000376266

ENSP00000353636 ENSP00000376265 ENSP00000376263

Human Recombinant Proteins

	Invitrogen human recombinant proteins for CAMKK2
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for CAMKK2
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (CAMKK2)
	Human Recombinant Proteins from Abnova (CAMKK2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	TAS	11395482
GO:0005737	cytoplasm	IEA	--

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Antibodies for CAMKK2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for CAMKK2
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for CAMKK2
	Antibodies from Abcam (CAMKK2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CAMKK2)
	Novus Biologicals Antibodies for CAMKK2

Assays for CAMKK2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q96RR4

ProtoNet protein and cluster: Q96RR4

UniProtKB/Swiss-Prot: KKCC2_HUMAN, Q96RR4

Domain: The autoinhibitory domain overlaps with the calmodulin binding region and may be involved

in intrasteric autoinhibition

Domain: The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as

substrates (By similarity)

Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CAMKK2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CAMKK2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 7): NM_006549

Applied Biosystems Silencer® siRNAs for CAMKK2

Sigma-Aldrich siRNA and siRNA Panels for CAMKK2

Sigma-Aldrich shRNA Panels and shRNA for CAMKK2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CAMKK2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 7): NM_006549
Myc/DDK tagged cDNA clones in CMV expression vector (see all 7): NM_006549
untagged cDNA clones in CMV expression vector (see all 10): NM_006549

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006549

UniProtKB/Swiss-Prot: KKCC2_HUMAN, Q96RR4

Function: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered

signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3

phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6

lacking part of the calmodulin-binding domain are inactive. Seems to be involved in hippocampal

activation of CREB1 (By similarity)

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme regulation: Activated by Ca(2+)/calmodulin. Binding of calmodulin may releave intrasteric

autoinhibition. Autophosphorylation does not alter activity or regulation by Ca(2+)/calmodulin. In

part, activity is independent on Ca(2+)/calmodulin (By similarity)

Enzyme Number (IUBMB): EC 2.7.11.17

Genatlas biochemistry entry for CAMKK2:

calcium/calmodulin-dependent protein kinase,kinase 2,beta,expressed as a flag-tagged protein in

human non small cell lung cancer

5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Camkk2):

adipose tissue

behavior/neurological

growth/size

homeostasis/metabolism

nervous system

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004683	calmodulin-dependent protein kinase activity	IEA	--
GO:0004713	protein tyrosine kinase activity	TAS	11395482
GO:0005509	calcium ion binding	IDA	11395482
GO:0005516	calmodulin binding	TAS	11395482

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for CAMKK2 (Your Favorite Gene powered by Ingenuity)

Calcium Signaling

GeneDecks CAMKK2 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CAMKK2

5/17 Interacting proteins for CAMKK2 (ENSP00000312741³) via UniProtKB, MINT, and/or STRING (see all 17 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CALM3	ENSP00000291295³	STRING (score=.923)
KRIT1	ENSP00000344668³	STRING (score=.918)
CAMK1	ENSP00000256460³	STRING (score=.892)
PRKAB1	ENSP00000229328³	STRING (score=.892)
PRKAG1	ENSP00000323867³	STRING (score=.888)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000165	MAPKKK cascade	TAS	11395482
GO:0019722	calcium-mediated signaling	TAS	11395482
GO:0045859	regulation of protein kinase activity	TAS	11395482
GO:0045941	positive regulation of transcription	TAS	11395482
GO:0046777	protein amino acid autophosphorylation	IDA	11395482

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for CAMKK2 available from Tocris Bioscience

Compound	Action	CAS number
STO-609 acetate	Selective CaM kinase kinase inhibitor	[52029-86-4]

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4 Novoseek chemical compound relationships for CAMKK2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
calcium	53.57	35	9859994 (3), 9662074 (2), 9822657 (2), 16497986 (2) (see all 16)
atp	36.03	4	18687367 (3), 10770941 (1)
forskolin	25.67	3	10187789 (1), 15469938 (1), 9195898 (1)
cyclic amp	10.38	1	15764842 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CAMKK2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CAMKK2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 7): NM_006549

Sigma-Aldrich siRNA and siRNA Panels for CAMKK2

Sigma-Aldrich shRNA Panels and shRNA for CAMKK2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_006549 NM_153499 NM_153500 NM_172214 NM_172215 NM_172216 NM_172226

REFSEQ mRNAs for CAMKK2 gene (7 alternative transcripts):

NM_006549.3 NM_153499.2 NM_153500.1 NM_172214.1 NM_172215.1 NM_172216.1 NM_172226.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_006549 NM_153499 NM_153500 NM_172214 NM_172215 NM_172216 NM_172226

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 7): NM_006549
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 7): NM_006549
                                 untagged cDNA clones in CMV expression vector (see all 10): NM_006549

Additional cDNA sequence:

AB018330.2 AB081336.1 AB081337.1 AF091074.1 AF101264.1 AF287630.1 AF287631.1 AF321385.1

AF321386.1 AF321387.1 AF321388.1 AF425668.1 AK024748.1 AK292072.1 AK300865.1 AK311473.1

AL834322.1 BC000318.2 BC026060.2 CR601834.1

23 DOTS entries:

DT.100824426 DT.95150357 DT.95150349 DT.455652 DT.100824425 DT.100824423 DT.86846422 DT.95150335

DT.92446457 DT.121180026 DT.121180044 DT.75101428 DT.100824430 DT.95150362 DT.100824424 DT.121180053

DT.100824429 DT.121180024 DT.121180014 DT.121180045 DT.121180049 DT.91744128 DT.95150355

24/328 AceView cDNA sequences (see all 328 ):

NM_172216 BQ883314 CN485118 CB152163 CA431335 T33239 AL834322 CF272493

BG035395 CB265340 AI311536 BQ720725 AI656058 NM_153500 BM928748 BU902211

BM547242 BM723151 AW627348 BE939864 CB152090 BM552231 T31199 BF434093

highest scoring ESTs for CAMKK2:

AB018330 AF287630 AF287631 AF321385 AF321386 AF321387 AF321388 AW014001 AA090321 AA099102

Unigene Cluster for CAMKK2:

Calcium/calmodulin-dependent protein kinase kinase 2, beta

Hs.297343 [show with all ESTs]

Unigene Representative Sequence: NM_006549

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for CAMKK2 (see all 16 )

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7a	·	7b	·	7c	·	7d	·	7e	^	8a	·	8b	^	9	^	10	^	11a	·	11b	^	12	^	13a	·	13b	·	13c	·	13d	^
SP1:
SP2:
SP3:
SP4:
SP5:													-		-						-		-		-		-		-								-		-

ExUns:	14	^	15	^	16a	·	16b	·	16c	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^	24a	·	24b	^	25
SP1:																							-		-		-
SP2:
SP3:																	-				-		-
SP4:																	-						-
SP5:

About this scheme

ECgene alternative splicing isoforms for CAMKK2

9 Ensembl transcripts including schematic representations:

ENST00000324774 ENST00000347034 ENST00000402834 ENST00000404169 ENST00000337174 ENST00000392474

ENST00000360452 ENST00000392473 ENST00000392471

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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CAMKK2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CAMKK2

¹ / ² / ³

10 probe-sets matching CAMKK2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38716_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.91	AB018330	0.80	1.00	0.91	1
64341_f_at²^{, 3}	U95-C	1	1.00	1.00	0.98	1.09	AW014001	0.80	1.00	0.91	1
213812_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AK024748	0.60	1.00	0.82	1
210787_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF140507	0.20	1.00	0.72	1
207359_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006549	0.60	1.00	0.82	1
212252_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AA181179	0.40	1.00	0.76	1
213812_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210787_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207359_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212252_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AACTTAAGAG

SOURCE GeneReport for Unigene cluster: Hs.297343
Expression variation in blood from EXPOLDB for CAMKK2
UniProtKB/Swiss-Prot: KKCC2_HUMAN, Q96RR4
Tissue specificity: Ubiquitously expressed with higher levels in the brain. Intermediate levels are
detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CAMKK2 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CAMKK2¹	--	calcium/calmodulin-dependent protein kinase kinase more	90.8(n) 93.58(a)	486263 XM_543388.2 XP_543388.2
cow (Bos taurus)	CAMKK2¹	--	calcium/calmodulin-dependent protein kinase kinase more	90.25(n) 92.39(a)	509084 NM_001075390.1 NP_001068858.1
rat (Rattus norvegicus)	Camkk2¹	--	calcium/calmodulin-dependent protein kinase kinase more	88.36(n) 92.67(a)	83506 NM_031338.1 NP_112628.1
mouse (Mus musculus)	Camkk2^{1, 5}	5⁵	calcium/calmodulin-dependent protein kinase kinase more^{1, 5}	86.33(n)¹ 91.95(a)¹	207565¹ NM_145358.1¹ NP_663333.1¹ AA386832⁵ AF453383⁵ (see all 18)
chicken (Gallus gallus)	CAMKK2¹	--	calcium/calmodulin-dependent protein kinase kinase more	76.41(n) 80.12(a)	396405 XM_415134.2 XP_415134.2

About this table Species with no ortholog for CAMKK2

ENSEMBL Gene Tree for CAMKK2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CAMKK2 gene

CAMKK1² STK11²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/459 NCBI SNPs in CAMKK2 are shown (see all 459 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 122)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs1063843^1,2	A,C,F,H,O	120166070(+)	`AGCCAC/TGATGT`	7	--	int¹ ut3¹		18	EA MN EU WA NA	3134
	rs1653586^1,2	A,C,F,H,O	120159958(+)	`TAGTTG/TTCTCT`	5	--	ut3¹ ese³		17	MN EA NA EU WA	1656
	rs3817190^1,2	A,C,F,H	120196460(+)	`GGAGGT/AGTCAA`	7	S/T	mis¹ ese³		5	NS EU EA WA	843
	rs2567982^1,2	A,C,F,H	120160097(+)	`GAAAAA/GTCTGC`	5	--	ut3¹		11	NA EU EA WA	980
	rs1653587^1,2	A,C,F,H	120160615(+)	`GACAGA/GGCTGG`	5	--	ut3¹		8	MN NA EU EA WA	740
	rs1653591^1,2	A,C,F,H	120165521(+)	`cTGCTG/AGTCAA`	7	--	int¹ ng5¹		7	EU EA WA NA	554
--	rs1140886^1,2	C,F,H	120165919(-)	`ccaccA/Gtcaac`	7	--	ut3¹ int¹		16	MN EU EA WA NA	1582
	rs1132780^1,2	C,F,H	120175479(-)	`AGACCC/TGCAAG`	7	R/C	mis¹		14	MN EU EA WA NA NS	1611
	rs1653590^1,2	C,F,H	120162155(+)	`GAGCAG/ACTGTC`	5	--	ut3¹ ese³		7	MN EU EA WA NA	772
	rs1653589^1,2	C,F,H	120161921(+)	`TTCATC/TGGCTC`	5	--	ut3¹ ese³		5	MN EU EA WA	602

About this table

HapMap Linkage Disequilibrium images for CAMKK2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

Human Genome Epidemiology Navigator: CAMKK2 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/71 PubMed articles for CAMKK2 gene (see all 71 ):

Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase. (PubMed id 9662074)^{1, 2, 3, 4} Hsu L.-S.... Chen J.-Y. (1998)
Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity. (PubMed id 11395482)^{1, 3, 4} Hsu L.-S.... Chen J.-Y. (2001)
Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta. (PubMed id 9822657)^{1, 3, 4} Anderson K.A.... Means A.R. (1998)
Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells. (PubMed id 12935886)^{1, 3, 4} Ishikawa Y....Kobayashi R. (2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{3, 4} Nakajima D.... Nagase T. (2002)
Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)^{3, 4} Nagase T....Ohara O. (1998)
Inhibition of the Ca2+/calmodulin-dependent protein kinase I cascade by cAMP-dependent protein kinase. (PubMed id 10187789)^{1, 3} Matsushita M. and Nairn A.C. (1999)
Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders. (PubMed id 17197037)^{1, 3} Erhardt A....Holsboer F. (2007)
Thrombin activates AMP-activated protein kinase in endothelial cells via a pathway involving Ca2+/calmodulin-dependent protein kinase kinase beta. (PubMed id 16880506)^{1, 3} Stahmann N....Heller R. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 10645	HGNC: 1470	AceView: CAMKK2	Ensembl:ENSG00000110931	euGenes: HUgn10645
ECgene: CAMKK2	H-InvDB: CAMKK2

(According to HUGE)
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HUGE: KIAA0787

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for CAMKK2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CAMKK2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CAMKK2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CAMKK2		Antibodies for CAMKK2
	Explore super-pooled esiRNAs		Proteins for CAMKK2
	Lentivirus-delivered shRNAs for CAMKK2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CAMKK2)
	Antibodies (CAMKK2)
	Chimera RNAi (CAMKK2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for CAMKK2

	Recombinant Proteins (CAMKK2)
	Antibodies (CAMKK2)

Search OriGene for CAMKK2

Tocris compounds for CAMKK2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CAMKK2

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CAMKK2 Gene at Home site.
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CAMKK2 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for CAMKK2

Summaries
for CAMKK2

Genomic Location
for CAMKK2

Proteins
for CAMKK2

Protein Domains/
Families
for CAMKK2

Gene Function
for CAMKK2

Pathways & Interactions
for CAMKK2

Drugs & Compounds
for CAMKK2

Transcripts
for CAMKK2

Expression
for CAMKK2

Orthologs
for CAMKK2

Paralogs
for CAMKK2

SNPs/Variants
for CAMKK2

Disorders & Mutations
for CAMKK2

Medical News
for CAMKK2

Publications
for CAMKK2

Search for CAMKK2

Genome Databases showing CAMKK2

Other Databases showing CAMKK2

Specialized Databases showing CAMKK2

Licensable Technologies
for CAMKK2

Services
for CAMKK2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CAMKK2 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor CAMKK2

Summariesfor CAMKK2

Genomic Locationfor CAMKK2

Proteinsfor CAMKK2

Protein Domains/Familiesfor CAMKK2

Gene Functionfor CAMKK2

Pathways & Interactionsfor CAMKK2

Drugs & Compoundsfor CAMKK2

Transcriptsfor CAMKK2

Expression for CAMKK2

Orthologsfor CAMKK2

Paralogsfor CAMKK2

SNPs/Variantsfor CAMKK2

Disorders & Mutationsfor CAMKK2

Medical Newsfor CAMKK2

Publicationsfor CAMKK2

Search for CAMKK2

Genome Databases showing CAMKK2

Other Databases showing CAMKK2

Specialized Databases showing CAMKK2

Licensable Technologiesfor CAMKK2

Servicesfor CAMKK2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CAMKK2

Summaries
for CAMKK2

Genomic Location
for CAMKK2

Proteins
for CAMKK2

Protein Domains/
Families
for CAMKK2

Gene Function
for CAMKK2

Pathways & Interactions
for CAMKK2

Drugs & Compounds
for CAMKK2

Transcripts
for CAMKK2

Expression
for CAMKK2

Orthologs
for CAMKK2

Paralogs
for CAMKK2

SNPs/Variants
for CAMKK2

Disorders & Mutations
for CAMKK2

Medical News
for CAMKK2

Publications
for CAMKK2

Licensable Technologies
for CAMKK2

Services
for CAMKK2