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CAMKK2 Gene

protein-coding   GIFtS: 70
GCID: GC12M121675

Calcium/Calmodulin-Dependent Protein Kinase Kinase 2, Beta

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calcium/Calmodulin-Dependent Protein Kinase Kinase 2, Beta1 2     Calcium/Calmodulin-Dependent Protein Kinase Beta2
CAMKKB2 3 5     Calcium/Calmodulin-Dependent Protein Kinase Kinase 22
CaM-Kinase Kinase 22 3     CAMKK Beta Protein2
CaM-Kinase Kinase Beta2 3     EC 2.7.11.173
CaM-KK 22 3     Calcium/Calmodulin-Dependent Protein Kinase Kinase Beta3
CaM-KK Beta2 3     CaMKK 23
KIAA07873 5     CaMKK Beta3
CAMKK2     EC 2.7.118

External Ids:    HGNC: 14701   Entrez Gene: 106452   Ensembl: ENSG000001109317   OMIM: 6150025   UniProtKB: Q96RR43   

Export aliases for CAMKK2 gene to outside databases

Previous GC identifers: GC12M120537 GC12M121255 GC12M121458 GC12M120087 GC12M120138 GC12M120159 GC12M118685


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CAMKK2 Gene:
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the
Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the
calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4.
Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest
expression in the brain and influences signalling cascades involved with learning and memory, neuronal
differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple
transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo
autophosphorylation and to phosphorylate downstream kinases. (provided by RefSeq, Jul 2012)

GeneCards Summary for CAMKK2 Gene:
CAMKK2 (calcium/calmodulin-dependent protein kinase kinase 2, beta) is a protein-coding gene. Diseases associated with CAMKK2 include anxiety disorder, and mantle cell lymphoma. GO annotations related to this gene include protein tyrosine kinase activity and calcium ion binding. An important paralog of this gene is CAMKK1.

UniProtKB/Swiss-Prot: KKCC2_HUMAN, Q96RR4
Function: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade
involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4.
Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain
are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting
of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity).
Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth.
Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching

summary for CAMKK2 Gene:
Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second
messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through
autoinhibition. Increases in Ca2+ levels allows calmodulin to relieve this autoinhibition and activate the
kinase activity. There are two main classes of CaMKs; mulitfunctional CaMKs (CaMKK, CaMKI, CaMKII and
CaMKIV) which have multiple downstream targets and substrate-specific CaMKs (CaMKIII) which have only one
known downstream target. All CaMKs, with the exception of CaMKII, exist as monomers and most are expressed
ubiquitously. Some subtypes display specific distributions, for example, CaMKIVbeta is expressed exclusively
in cerebellar granule cells. CaMKs have numerous cellular functions and they influence processes as diverse
as gene transcription, cell survival, apoptosis, cytoskeletal re-organization and learning and memory.

Gene Wiki entry for CAMKK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CAMKK2 gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CAMKK2 promoter sequence
   Search Chromatin IP Primers for CAMKK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CAMKK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.2   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.2

CAMKK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAMKK2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M121675:  view genomic region     (about GC identifiers)

Start:
121,675,495 bp from pter      End:
121,736,111 bp from pter
Size:
60,617 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KKCC2_HUMAN, Q96RR4 (See protein sequence)
Recommended Name: Calcium/calmodulin-dependent protein kinase kinase 2  
Size: 588 amino acids; 64746 Da
Subunit: Interacts with calmodulin (By similarity)
Sequence caution: Sequence=AAC72943.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA34507.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAD38990.1;
Type=Miscellaneous discrepancy; Note=Intron retention;
1 PDB 3D structure from and Proteopedia for CAMKK2:
2ZV2 (3D)    
Secondary accessions: A8K7Q7 O94883 Q8IUG2 Q8IUG3 Q8N3I4 Q8WY03 Q8WY04 Q8WY05 Q8WY06 Q96RP1
Q96RP2 Q96RR3 Q9BWE9 Q9UER3 Q9UES2 Q9Y5N2
Alternative splicing: 7 isoforms:  Q96RR4-1   Q96RR4-2   Q96RR4-3   Q96RR4-4   Q96RR4-5   Q96RR4-6   Q96RR4-7   (Inactive. Does not activate CAMK1 and CAMK4)

Explore the universe of human proteins at neXtProt for CAMKK2: NX_Q96RR4

Explore proteomics data for CAMKK2 at MOPED

Post-translational modifications: 

  • Autophosphorylated and phosphorylated by PKA. Each isoform may show a different pattern of phosphorylation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for CAMKK2 (Q96RR4)
     DLITRML  GHIKIAD  GKGSYGVV  GTPAFMAPE 


    See CAMKK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (9 alternative transcripts): 
    NP_001257414.1  NP_001257415.1  NP_006540.3  NP_705719.2  NP_705720.1  NP_757363.1  NP_757364.1  NP_757365.1  
    NP_757380.1  

    ENSEMBL proteins: 
     ENSP00000376266   ENSP00000321230   ENSP00000445944   ENSP00000336634   ENSP00000312741  
     ENSP00000441352   ENSP00000388368   ENSP00000384600   ENSP00000384591   ENSP00000388273  
     ENSP00000376265   ENSP00000444894   ENSP00000445400  

    CAMKK2 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CAMKK2 Protein
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    OriGene Protein Over-expression Lysate for CAMKK2
    OriGene MassSpec for CAMKK2
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    GenScript Custom Purified and Recombinant Proteins Services for CAMKK2
    Novus Biologicals CAMKK2 Proteins
    Novus Biologicals CAMKK2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CAMKK2

    CAMKK2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CAMKK2
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    Cell Signaling Technology (CST) Antibodies for CAMKK2 
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    Novus Biologicals CAMKK2 Antibodies
    Abcam antibodies for CAMKK2
    Cloud-Clone Corp. Antibodies for CAMKK2
    ThermoFisher Antibody for CAMKK2
    LSBio Antibodies in human, mouse, rat for CAMKK2

    CAMKK2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. CLIAs for CAMKK2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: calcium/calmodulin-dependent protein kinase kinase 2, beta
    Meta subfamily

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q96RR4

    ProtoNet protein and cluster: Q96RR4

    UniProtKB/Swiss-Prot: KKCC2_HUMAN, Q96RR4
    Domain: The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric
    autoinhibition
    Domain: The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates (By
    similarity)
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    CAMKK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KKCC2_HUMAN, Q96RR4
    Function: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade
    involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4.
    Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain
    are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting
    of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity).
    Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth.
    Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by Ca(2+)/calmodulin. Binding of calmodulin may relieve intrasteric autoinhibition.
    Autophosphorylation does not alter activity or regulation by Ca(2+)/calmodulin. In part, activity is independent
    on Ca(2+)/calmodulin (By similarity)
    Induction: Isoform 1 is up-regulated by PKA pathway

         Genatlas biochemistry entry for CAMKK2:
    calcium/calmodulin-dependent protein kinase,kinase 2,beta,expressed as a flag-tagged protein in human non small
    cell lung cancer

         Enzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.171

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004683calmodulin-dependent protein kinase activity IEA--
    GO:0004713protein tyrosine kinase activity TAS11395482
    GO:0005509calcium ion binding IDA11395482
         
    CAMKK2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CAMKK2:
     Decreased focal adhesion (FA)   Decreased number of cells in m  Increased cell death HMECs cel 

         6 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Camkk2):
     adipose tissue  behavior/neurological  growth/size/body  homeostasis/metabolism  nervous system 
     no phenotypic analysis 

    CAMKK2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CAMKK2: Camkk2tm1Tch Camkk2tm1.1Arm Camkk2tm1Kpg

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CAMKK2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CAMKK2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAMKK2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAMKK2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CAMKK2:
    hsa-mir-103a-3p (MIRT027179), hsa-mir-100-5p (MIRT048541), hsa-mir-185-5p (MIRT045326), hsa-mir-16-5p (MIRT031851)

    Block miRNA regulation of human, mouse, rat CAMKK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CAMKK2 (see all 60):
    hsa-miR-3194-5p hsa-miR-411 hsa-miR-29a hsa-miR-25 hsa-miR-16-1* hsa-miR-30d hsa-miR-218 hsa-miR-342-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CAMKK2
    Predesigned siRNA for gene silencing in human, mouse, rat CAMKK2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CAMKK2

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 7): CAMKK2 (NM_006549)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAMKK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMKK2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMKK2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KKCC2_HUMAN, Q96RR4: Nucleus (By similarity). Cytoplasm. Cell projection. Note=Predominantly nuclear in
    unstimulated cells (By similarity). Found in the cytoplasm and neurites after forskolin induction
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular TAS11395482
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0042995cell projection IEA--

    CAMKK2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CAMKK2 About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response Function of MEF2 in T lymphocytes
    Development Role of HDAC and calcium calmodulin dependent kinase CaMK in control of skeletal myogenesis0.38
    Immune response Function of MEF2 in T lymphocytes0.38
    2CREB Pathway
    IP3 Pathway0.68
    3Development Angiotensin activation of ERK
    Signal transduction IP3 signaling0.43
    4Ca-dependent events
    Signal transduction Calcium signaling0.35
    5RNA Polymerase I Promoter Opening
    Alcoholism0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CAMKK2
        IP3 Pathway
    Dopamine-DARPP32 Feedback onto cAMP Pathway

    2 Cell Signaling Technology (CST) Pathways for CAMKK2
        Neuroscience
    Glucose / Energy Metabolism

    4 GeneGo (Thomson Reuters) Pathways for CAMKK2
        Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Immune response Function of MEF2 in T lymphocytes
    Signal transduction Calcium signaling
    Signal transduction IP3 signaling

    1 BioSystems Pathway for CAMKK2
        AMPK signaling


    3 Kegg Pathways  (Kegg details for CAMKK2):
        Adipocytokine signaling pathway
    Oxytocin signaling pathway
    Alcoholism


    CAMKK2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CAMKK2
    Interactions:

        GeneGlobe Interaction Network for CAMKK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CAMKK2 (Q96RR43 ENSP000003127414) via UniProtKB, MINT, STRING, and/or I2D (see all 554)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    ENSG00000232804P081073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade TAS11395482
    GO:0006468protein phosphorylation IDA11395482
    GO:0018108peptidyl-tyrosine phosphorylation TAS11395482
    GO:0019722calcium-mediated signaling TAS11395482
    GO:0045859regulation of protein kinase activity TAS11395482

    CAMKK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for CAMKK2
      Browse compounds at ApexBio 

    Compounds for CAMKK2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    NH 125CaM kinase III (eEF-2 kinase) inhibitor[278603-08-0]
    STO-609 acetateSelective CaM kinase kinase inhibitor[52029-86-4]
    A 484954CaM kinase III (eEF-2 kinase) inhibitor[142557-61-7]
    KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
    Arcyriaflavin APotent cdk4/cyclin D1 and CaM Kinase II inhibitor. Antiviral agent (anti-HCMV)[118458-54-1]

    3 HMDB Compounds for CAMKK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--

    6 Novoseek inferred chemical compound relationships for CAMKK2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 53.9 39 9859994 (3), 19958286 (2), 16497986 (2), 9822657 (2) (see all 19)
    atp 33.6 4 18687367 (3), 10770941 (1)
    nmda 30.1 5 9859994 (2), 15689566 (1), 18184567 (1)
    serine 24.1 1 9859994 (1)
    forskolin 23.5 3 10187789 (1), 15469938 (1), 9195898 (1)
    cyclic amp 8.19 1 15764842 (1)



    CAMKK2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for CAMKK2 gene (9 alternative transcripts): 
    NM_001270485.1  NM_001270486.1  NM_006549.3  NM_153499.2  NM_153500.1  NM_172214.2  NM_172215.2  NM_172216.1  
    NM_172226.2  

    Unigene Cluster for CAMKK2:

    Calcium/calmodulin-dependent protein kinase kinase 2, beta
    Hs.297343  [show with all ESTs]
    Unigene Representative Sequence: NM_006549
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392474 ENST00000347034 ENST00000538733 ENST00000337174(uc001tzt.3)
    ENST00000324774(uc001tzu.3 uc001tzv.3 uc001tzw.3 uc001tzx.3 uc001tzy.3 uc001uaa.1)
    ENST00000545538(uc001tzz.1) ENST00000412367 ENST00000404169(uc001uad.2)
    ENST00000402834 ENST00000446440 ENST00000392473(uc001uab.3 uc001uac.3)
    ENST00000535524 ENST00000542540 ENST00000539380 ENST00000543477 ENST00000544485

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Selected qRT-PCR Assays for microRNAs that regulate CAMKK2 (see all 60):
    hsa-miR-3194-5p hsa-miR-411 hsa-miR-29a hsa-miR-25 hsa-miR-16-1* hsa-miR-30d hsa-miR-218 hsa-miR-342-3p
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      QuantiFast Probe-based Assays in human, mouse, rat CAMKK2

    Additional mRNA sequence: 

    AB018330.2 AB081336.1 AB081337.1 AF091074.1 AF101264.1 AF287630.1 AF287631.1 AF321385.1 
    AF321386.1 AF321387.1 AF321388.1 AF425668.1 AK024748.1 AK292072.1 AK300865.1 AK311473.1 
    AL834322.1 BC000318.2 BC026060.2 

    23 DOTS entries:

    DT.100824426  DT.95150357  DT.95150349  DT.455652  DT.100824425  DT.100824423  DT.86846422  DT.95150335 
    DT.92446457  DT.121180026  DT.121180044  DT.100824430  DT.75101428  DT.95150362  DT.100824424  DT.121180053 
    DT.100824429  DT.121180024  DT.121180014  DT.121180045  DT.121180049  DT.91744128  DT.95150355 

    Selected AceView cDNA sequences (see all 328):

    AB018330 CB265340 BM723151 BI225425 T33239 AI972885 BF926869 BC026060 
    AI349309 BC000318 BE939864 NM_153500 AL119772 AI928437 NM_172215 BM928748 
    AL834322 AI815054 BM794142 BF221898 NM_006549 CN485118 BU902211 BM718658 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CAMKK2 (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                      -     -                 -     -     -     -     -                       -     -                                       

    ExUns: 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25
    SP1:                                                                    -     -     -         
    SP2:                                                                                          
    SP3:                                                  -           -     -                     
    SP4:                                                  -                 -                     
    SP5:                                                                                          


    ECgene alternative splicing isoforms for CAMKK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CAMKK2 expression in normal human tissues (normalized intensities)      CAMKK2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTTAAGAG
    CAMKK2 Expression
    About this image


    CAMKK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebellum
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Bone (Muscoskeletal System)
             Bone Marrow
    CAMKK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CAMKK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.297343

    UniProtKB/Swiss-Prot: KKCC2_HUMAN, Q96RR4
    Tissue specificity: Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in
    spleen, prostate, thyroid and leukocytes. The lowest level is in lung

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CAMKK2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Camkk21 , 5 calcium/calmodulin-dependent protein kinase kinase more1, 5 87.09(n)1
    91.67(a)1
      5 (62.55 cM)5
    2075651  NM_001199676.11  NP_001186605.11 
     1227311735 
    chicken
    (Gallus gallus)
    Aves CAMKK21 calcium/calmodulin-dependent protein kinase kinase more 79.1(n)
    83.95(a)
      396405  XM_004945549.1  XP_004945606.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    74(a)
    many ↔ many
    GL343913.1(137250-145095)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia camkk21 calcium/calmodulin-dependent protein kinase kinase more 71.3(n)
    77.02(a)
      100135108  XM_002937701.2  XP_002937747.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1947371 zgc:194737 66.75(n)
    69.63(a)
      100170786  NM_001130625.2  NP_001124097.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG176983 protein amino acid phosphorylation
    protein serine/threonine more
    54(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea ckk-11 , 3 ckk-11 56(a)3
    57.56(n)1
    56.01(a)1
      III(5723519-5725386)3
    1822781  NM_001025982.31  NP_001021153.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TOS3(YGL179C)4 Protein kinase, related to and functionally redundant more   --   7(165091-163409) 852696  NP_011336.1 


    ENSEMBL Gene Tree for CAMKK2 (if available)
    TreeFam Gene Tree for CAMKK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CAMKK2 gene
    CAMKK12  STK112  
    Selected SIMAP similar genes for CAMKK2 using alignment to 5 protein entries:     KKCC2_HUMAN (see all proteins) (see all similar genes):
    CAMKK1    STK38L    MAPK8    RPS6KA1    STK11    BRSK2
    FGFR1    MARK4    RPS6KA2    CAMK1    FLT4    MAPK14
    BRAF    CDK7    HUNK    MAP4K5    PHKG1    TXK

    CAMKK2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CAMKK2 (see all 1846)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0406124
    A colorectal adenocarcinoma sample4--see VAR_0406122 A T mis40--------
    VAR_0406114
    A lung neuroendocrine carcinoma sample4--see VAR_0406112 P L mis40--------
    rs116098771,2
    H--121472982(+) tttttA/Taattt 7 -- ds5001 int10--------
    rs116117621,2
    H--121472984(+) ttttaA/Tttttt 7 -- ds5001 int10--------
    rs1387816941,2
    C--121473001(+) TTTTT-/T/TA  
            
    AAGAG
    7 -- ds5001 int10--------
    rs342837011,2
    C--121473002(+) TTTTT-/AAGAGA 7 -- ds5001 int10--------
    rs798861211,2
    C--121473002(+) TTTTTA/TAGAGA 7 -- ds5001 int10--------
    rs71361061,2
    C,F,A--121473120(+) cggccG/Agcacc 7 -- ds5001 int13Minor allele frequency- A:0.11NA WA 240
    rs1394091671,2
    --121473141(+) ACCCAC/GTCACA 7 -- ds5001 int10--------
    rs108498611,2
    C,F,A,H--121473159(+) CTGGCG/ACTACT 7 -- ds5001 int18Minor allele frequency- A:0.23NS EA CSA WA NA 750

    HapMap Linkage Disequilibrium report for CAMKK2 (121675495 - 121736111 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CAMKK2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2746484CNV Deletion23290073
    esv2660506CNV Deletion23128226
    esv2746485CNV Deletion23290073
    esv1008629CNV Insertion20482838
    nsv513372CNV Insertion21212237
    nsv455731CNV Loss19166990
    nsv899564CNV Loss21882294
    nsv521928CNV Gain19592680
    nsv899565CNV Gain+Loss21882294

    Human Gene Mutation Database (HGMD): CAMKK2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CAMKK2
    DNA2.0 Custom Variant and Variant Library Synthesis for CAMKK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615002    OMIM disorders: --

    18 diseases for CAMKK2:    About MalaCards
    anxiety disorder    mantle cell lymphoma    lateral sclerosis    amyotrophic lateral sclerosis
    cervical cancer    cervicitis    schizophrenia    tonsillitis
    endotheliitis    hypoxia    neuronitis    thyroiditis
    lung cancer    prostatitis    prostate cancer    cerebritis
    breast cancer    malaria


    CAMKK2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CAMKK2
    Human Genome Epidemiology (HuGE) Navigator: CAMKK2 (4 documents)

    Export disorders for CAMKK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CAMKK2 gene, integrated from 10 sources (see all 108):
    (articles sorted by number of sources associating them with CAMKK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase. (PubMed id 9662074)1, 2, 3, 9 Hsu L.-S.... Chen J.-Y. (J. Biomed. Sci. 1998)
    2. Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity. (PubMed id 11395482)1, 2, 9 Hsu L.-S.... Chen J.-Y. (J. Biol. Chem. 2001)
    3. Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders. (PubMed id 17197037)1, 4, 9 Erhardt A....Holsboer F. (J Affect Disord 2007)
    4. Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta. (PubMed id 9822657)1, 2, 9 Anderson K.A.... Means A.R. (J. Biol. Chem. 1998)
    5. Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells. (PubMed id 12935886)1, 2, 9 Ishikawa Y....Kobayashi R. (FEBS Lett. 2003)
    6. Differential effects of PKA-controlled CaMKK2 variants on neuronal differentiation. (PubMed id 21957496)1, 2 Cao W.... Xie J. (RNA Biol. 2011)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder. (PubMed id 16673375)1, 4 Barden N....MA1ller-Myhsok B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10645 HGNC: 1470 AceView: CAMKK2 Ensembl:ENSG00000110931 euGenes: HUgn10645
    ECgene: CAMKK2 Kegg: 10645 H-InvDB: CAMKK2

    (According to HUGE)
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    HUGE: KIAA0787

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CAMKK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CAMKK2 gene:
    Search GeneIP for patents involving CAMKK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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