Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CAMKK2 Gene

protein-coding   GIFtS: 70
GCID: GC12M121675

Calcium/Calmodulin-Dependent Protein Kinase Kinase 2, Beta

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Calcium/Calmodulin-Dependent Protein Kinase Kinase 2, Beta1 2     Calcium/Calmodulin-Dependent Protein Kinase Kinase 22
CaM-Kinase Kinase 22 3     CAMKK Beta Protein2
CaM-Kinase Kinase Beta2 3     EC 2.7.11.173
CaM-KK 22 3     KIAA07873
CaM-KK Beta2 3     Calcium/Calmodulin-Dependent Protein Kinase Kinase Beta3
CAMKKB2 3     CaMKK 23
CAMKK2     CaMKK Beta3
Calcium/Calmodulin-Dependent Protein Kinase Beta2     EC 2.7.118

External Ids:    HGNC: 14701   Entrez Gene: 106452   Ensembl: ENSG000001109317   OMIM: 6150025   UniProtKB: Q96RR43   

Export aliases for CAMKK2 gene to outside databases

Previous GC identifers: GC12M120537 GC12M121255 GC12M121458 GC12M120087 GC12M120138 GC12M120159 GC12M118685


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CAMKK2 Gene:
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the
Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the
calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4.
Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest
expression in the brain and influences signalling cascades involved with learning and memory, neuronal
differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple
transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo
autophosphorylation and to phosphorylate downstream kinases. (provided by RefSeq, Jul 2012)

GeneCards Summary for CAMKK2 Gene: 
CAMKK2 (calcium/calmodulin-dependent protein kinase kinase 2, beta) is a protein-coding gene. Diseases associated with CAMKK2 include anxiety disorder, and mantle cell lymphoma, and among its related super-pathways are Immune response Function of MEF2 in T lymphocytes and Signal transduction IP3 signaling. GO annotations related to this gene include protein tyrosine kinase activity and calcium ion binding. An important paralog of this gene is CAMKK1.

UniProtKB/Swiss-Prot: KKCC2_HUMAN, Q96RR4
Function: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade
involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4.
Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain
are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting
of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity).
Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth.
Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching

summary for CAMKK2 Gene:
Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second
messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through
autoinhibition. Increases in Ca2+ levels allows calmodulin to relieve this autoinhibition and activate the
kinase activity. There are two main classes of CaMKs; mulitfunctional CaMKs (CaMKK, CaMKI, CaMKII and
CaMKIV) which have multiple downstream targets and substrate-specific CaMKs (CaMKIII) which have only one
known downstream target. All CaMKs, with the exception of CaMKII, exist as monomers and most are expressed
ubiquitously. Some subtypes display specific distributions, for example, CaMKIVbeta is expressed exclusively
in cerebellar granule cells. CaMKs have numerous cellular functions and they influence processes as diverse
as gene transcription, cell survival, apoptosis, cytoskeletal re-organization and learning and memory.

Gene Wiki entry for CAMKK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009775.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CAMKK2 gene promoter:
         CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CAMKK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CAMKK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAMKK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.2   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.2

CAMKK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAMKK2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M121675:  view genomic region     (about GC identifiers)

Start:
121,675,495 bp from pter      End:
121,736,111 bp from pter
Size:
60,617 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KKCC2_HUMAN, Q96RR4 (See protein sequence)
Recommended Name: Calcium/calmodulin-dependent protein kinase kinase 2  
Size: 588 amino acids; 64746 Da
Subunit: Interacts with calmodulin (By similarity)
Subcellular location: Nucleus (By similarity). Cytoplasm. Cell projection. Note=Predominantly nuclear in
unstimulated cells (By similarity). Found in the cytoplasm and neurites after forskolin induction
Sequence caution: Sequence=AAC72943.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA34507.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAD38990.1;
Type=Miscellaneous discrepancy; Note=Intron retention;
1 PDB 3D structure from and Proteopedia for CAMKK2:
2ZV2 (3D)    
Secondary accessions: A8K7Q7 O94883 Q8IUG2 Q8IUG3 Q8N3I4 Q8WY03 Q8WY04 Q8WY05 Q8WY06 Q96RP1
Q96RP2 Q96RR3 Q9BWE9 Q9UER3 Q9UES2 Q9Y5N2
Alternative splicing: 7 isoforms:  Q96RR4-1   Q96RR4-2   Q96RR4-3   Q96RR4-4   Q96RR4-5   Q96RR4-6   Q96RR4-7   (Inactive. Does not activate CAMK1 and CAMK4)

Explore the universe of human proteins at neXtProt for CAMKK2: NX_Q96RR4

Explore proteomics data for CAMKK2 at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated and phosphorylated by PKA. Each isoform may show a different pattern of phosphorylation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96RR4

  • 4 DME Specific Peptides for CAMKK2 (Q96RR4)
     DLITRML  GHIKIAD  GKGSYGVV  GTPAFMAPE 

    CAMKK2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CAMKK2 Protein Expression
    REFSEQ proteins (9 alternative transcripts): 
    NP_001257414.1  NP_001257415.1  NP_006540.3  NP_705719.2  NP_705720.1  NP_757363.1  NP_757364.1  NP_757365.1  
    NP_757380.1  

    ENSEMBL proteins: 
     ENSP00000376266   ENSP00000321230   ENSP00000445944   ENSP00000336634   ENSP00000312741  
     ENSP00000441352   ENSP00000388368   ENSP00000384600   ENSP00000384591   ENSP00000388273  
     ENSP00000376265   ENSP00000444894   ENSP00000445400  

    Human Recombinant Protein Products for CAMKK2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for CAMKK2
    OriGene Protein Over-expression Lysate for CAMKK2
    OriGene MassSpec for CAMKK2 
    OriGene Custom Protein Services for CAMKK2
    GenScript Custom Purified and Recombinant Proteins Services for CAMKK2
    Novus Biologicals CAMKK2 Proteins
    Novus Biologicals CAMKK2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CAMKK2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular TAS11395482
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0042995cell projection IEA--

    CAMKK2 for ontologies           About GeneDecksing



    CAMKK2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CAMKK2
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CAMKK2 
    OriGene Antibodies for CAMKK2
    OriGene Custom Antibody Services for CAMKK2
    GenScript Custom Superior Antibodies Services for CAMKK2
    Novus Biologicals CAMKK2 Antibodies
    Abcam antibodies for CAMKK2
    Cloud-Clone Corp. Antibodies for CAMKK2 
    ThermoFisher Antibody for CAMKK2
    LSBio Antibodies in human, mouse, rat for CAMKK2 

    Assay Products for CAMKK2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CAMKK2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CAMKK2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CAMKK2 
    Cloud-Clone Corp. CLIAs for CAMKK2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: calcium/calmodulin-dependent protein kinase kinase 2, beta 
    Meta subfamily

    5/6 InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q96RR4

    ProtoNet protein and cluster: Q96RR4

    UniProtKB/Swiss-Prot: KKCC2_HUMAN, Q96RR4
    Domain: The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric
    autoinhibition
    Domain: The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates (By
    similarity)
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    CAMKK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KKCC2_HUMAN, Q96RR4
    Function: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade
    involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4.
    Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain
    are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting
    of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity).
    Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth.
    Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by Ca(2+)/calmodulin. Binding of calmodulin may relieve intrasteric autoinhibition.
    Autophosphorylation does not alter activity or regulation by Ca(2+)/calmodulin. In part, activity is independent
    on Ca(2+)/calmodulin (By similarity)
    Induction: Isoform 1 is up-regulated by PKA pathway

         Genatlas biochemistry entry for CAMKK2:
    calcium/calmodulin-dependent protein kinase,kinase 2,beta,expressed as a flag-tagged protein in human non small
    cell lung cancer

         Enzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.171

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004683calmodulin-dependent protein kinase activity IEA--
    GO:0004713protein tyrosine kinase activity TAS11395482
    GO:0005509calcium ion binding IDA11395482
         
    CAMKK2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CAMKK2:
     Decreased focal adhesion (FA)   Decreased number of cells in m  Increased cell death HMECs cel 

         6 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Camkk2):
     adipose tissue  behavior/neurological  growth/size  homeostasis/metabolism  nervous system 
     no phenotypic analysis 

    CAMKK2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CAMKK2: Camkk2tm1Tch Camkk2tm1.1Arm Camkk2tm1Kpg

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CAMKK2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CAMKK2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAMKK2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAMKK2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAMKK2
    8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate CAMKK2 (see all 60):
    hsa-miR-3194-5p hsa-miR-411 hsa-miR-29a hsa-miR-25 hsa-miR-16-1* hsa-miR-30d hsa-miR-218 hsa-miR-342-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CAMKK2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAMKK2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CAMKK2
    Sirion Biotech Customized adenovirus for overexpression of CAMKK2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CAMKK2 (see all 34)
    OriGene ORF clones in mouse, rat for CAMKK2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 7): CAMKK2 (NM_006549)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAMKK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMKK2
    Sirion Biotech Customized lentivirus for stable overexpression of CAMKK2 
                         Customized lentivirus expression plasmids for stable overexpression of CAMKK2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CAMKK2
    Search LifeMap BioReagents cell lines for CAMKK2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMKK2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CAMKK2 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response Function of MEF2 in T lymphocytes
    Immune response Function of MEF2 in T lymphocytes0.90
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis0.38
    2Signal transduction IP3 signaling
    Signal transduction IP3 signaling0.92
    3CREB Pathway
    IP3 Pathway0.68
    4fMLP Pathway
    Signal transduction Calcium signaling0.34
    5Alcoholism
    Alcoholism0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for CAMKK2
        Signal transduction Calcium signaling
    Immune response Function of MEF2 in T lymphocytes
    Signal transduction IP3 signaling
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CAMKK2
        IP3 Pathway
    Dopamine-DARPP32 Feedback onto cAMP Pathway

    2 Cell Signaling Technology (CST) Pathways for CAMKK2
        Neuroscience
    Glucose / Energy Metabolism

    4 GeneGo (Thomson Reuters) Pathways for CAMKK2
        Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Immune response Function of MEF2 in T lymphocytes
    Signal transduction Calcium signaling
    Signal transduction IP3 signaling

    1 BioSystems Pathway for CAMKK2
        AMPK signaling


    2         Kegg Pathways  (Kegg details for CAMKK2):
        Adipocytokine signaling pathway
    Alcoholism


    CAMKK2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CAMKK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/496 Interacting proteins for CAMKK2 (Q96RR43 ENSP000003127414) via UniProtKB, MINT, STRING, and/or I2D (see all 496)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    ENSG00000232804P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade TAS11395482
    GO:0006468protein phosphorylation IDA11395482
    GO:0019722calcium-mediated signaling TAS11395482
    GO:0045859regulation of protein kinase activity TAS11395482
    GO:0045893positive regulation of transcription, DNA-dependent TAS11395482

    CAMKK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CAMKK2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for CAMKK2

    Compounds for CAMKK2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    NH 125CaM kinase III (eEF-2 kinase) inhibitor[278603-08-0]
    STO-609 acetateSelective CaM kinase kinase inhibitor[52029-86-4]
    A 484954CaM kinase III (eEF-2 kinase) inhibitor[142557-61-7]
    KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
    Arcyriaflavin APotent cdk4/cyclin D1 and CaM Kinase II inhibitor. Antiviral agent (anti-HCMV)[118458-54-1]

    3 HMDB Compounds for CAMKK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--

    6 Novoseek inferred chemical compound relationships for CAMKK2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 53.9 39 9859994 (3), 19958286 (2), 16497986 (2), 9822657 (2) (see all 19)
    atp 33.6 4 18687367 (3), 10770941 (1)
    nmda 30.1 5 9859994 (2), 15689566 (1), 18184567 (1)
    serine 24.1 1 9859994 (1)
    forskolin 23.5 3 10187789 (1), 15469938 (1), 9195898 (1)
    cyclic amp 8.19 1 15764842 (1)

    Search CenterWatch for drugs/clinical trials and news about CAMKK2 / KKCC2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CAMKK2 gene (9 alternative transcripts): 
    NM_001270485.1  NM_001270486.1  NM_006549.3  NM_153499.2  NM_153500.1  NM_172214.2  NM_172215.2  NM_172216.1  
    NM_172226.2  

    Unigene Cluster for CAMKK2:

    Calcium/calmodulin-dependent protein kinase kinase 2, beta
    Hs.297343  [show with all ESTs]
    Unigene Representative Sequence: NM_006549
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392474 ENST00000347034 ENST00000538733 ENST00000337174(uc001tzt.3)
    ENST00000324774(uc001tzu.3 uc001tzv.3 uc001tzw.3 uc001tzx.3 uc001tzy.3 uc001uaa.1)
    ENST00000545538(uc001tzz.1) ENST00000412367 ENST00000404169(uc001uad.2)
    ENST00000402834 ENST00000446440 ENST00000392473(uc001uab.3 uc001uac.3)
    ENST00000535524 ENST00000542540 ENST00000539380 ENST00000543477 ENST00000544485

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAMKK2
    8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate CAMKK2 (see all 60):
    hsa-miR-3194-5p hsa-miR-411 hsa-miR-29a hsa-miR-25 hsa-miR-16-1* hsa-miR-30d hsa-miR-218 hsa-miR-342-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CAMKK2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAMKK2
    Clone
    Products:
         
    OriGene clones in human, mouse for CAMKK2 (see all 34)
    OriGene ORF clones in mouse, rat for CAMKK2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 7): CAMKK2 (NM_006549)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAMKK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMKK2
    Sirion Biotech Customized lentivirus for stable overexpression of CAMKK2 
                         Customized lentivirus expression plasmids for stable overexpression of CAMKK2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CAMKK2
    OriGene qSTAR qPCR primer pairs in human, mouse for CAMKK2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CAMKK2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAMKK2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAMKK2

    Additional mRNA sequence: 

    AB018330.2 AB081336.1 AB081337.1 AF091074.1 AF101264.1 AF287630.1 AF287631.1 AF321385.1 
    AF321386.1 AF321387.1 AF321388.1 AF425668.1 AK024748.1 AK292072.1 AK300865.1 AK311473.1 
    AL834322.1 BC000318.2 BC026060.2 

    23 DOTS entries:

    DT.100824426  DT.95150357  DT.95150349  DT.455652  DT.100824425  DT.100824423  DT.86846422  DT.95150335 
    DT.92446457  DT.121180026  DT.121180044  DT.100824430  DT.75101428  DT.95150362  DT.100824424  DT.121180053 
    DT.100824429  DT.121180024  DT.121180014  DT.121180045  DT.121180049  DT.91744128  DT.95150355 

    24/328 AceView cDNA sequences (see all 328):

    CN485118 BM908574 BF221898 NM_153500 AW627348 BI225425 AI815054 AI656058 
    BE939864 AW276068 AA633487 BQ720725 AI972885 T31199 BM552231 NM_172226 
    AW014001 AB018330 AL834322 BQ883314 BM828772 BM928748 CB152090 BM547242 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for CAMKK2 (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                      -     -                 -     -     -     -     -                       -     -                                       

    ExUns: 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25
    SP1:                                                                    -     -     -         
    SP2:                                                                                          
    SP3:                                                  -           -     -                     
    SP4:                                                  -                 -                     
    SP5:                                                                                          


    ECgene alternative splicing isoforms for CAMKK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CAMKK2 expression in normal human tissues (normalized intensities)      CAMKK2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTTAAGAG
    CAMKK2 Expression
    About this image


    CAMKK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/28 selected tissues (see all 28) fully expand
     
     Brain (Nervous System)    fully expand to see all 11 entries
             Cerebral Cortex
             postcentral gyrus   
     
     Epithelium (Reproductive System)    fully expand to see all 5 entries
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             neutrophils   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             testis ; cells in seminiferus ducts   

    See CAMKK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CAMKK2

    SOURCE GeneReport for Unigene cluster: Hs.297343

    UniProtKB/Swiss-Prot: KKCC2_HUMAN, Q96RR4
    Tissue specificity: Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in
    spleen, prostate, thyroid and leukocytes. The lowest level is in lung

        SABiosciences Custom PCR Arrays for CAMKK2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CAMKK2
    OriGene qSTAR qPCR primer pairs in human, mouse for CAMKK2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CAMKK2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAMKK2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAMKK2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMKK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CAMKK2 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Camkk21 , 5 calcium/calmodulin-dependent protein kinase kinase more1, 5 87.51(n)1
    91.82(a)1
      5 (62.55 cM)5
    2075651  NM_001199676.11  NP_001186605.11 
     1227311735 
    chicken
    (Gallus gallus)
    Aves CAMKK21 calcium/calmodulin-dependent protein kinase kinase more 76.41(n)
    80.12(a)
      396405  XM_415134.2  XP_415134.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1947371 zgc:194737 67.08(n)
    69.63(a)
      100170786  NM_001130625.1  NP_001124097.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG176981 , 3 protein amino acid phosphorylation
    protein serine/threonine more3
    CG176981
    54(a)3
    54.05(n)1
    57.03(a)1
      43799191  NM_001043169.11  NP_001036634.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ckk-13   -- 56(a)   III(5723519-5725386)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TOS3(YGL179C)4 Protein kinase, related to and functionally redundant more   --   7(165091-163409) 852696  NP_011336.1 


    ENSEMBL Gene Tree for CAMKK2 (if available)
    TreeFam Gene Tree for CAMKK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CAMKK2 gene
    CAMKK12  STK112  
    18/38 SIMAP similar genes for CAMKK2 using alignment to 6 protein entries:     KKCC2_HUMAN (see all proteins) (see all similar genes):
    CAMKK1    STK38L    MAPK8    RPS6KA1    STK11    BRSK2
    FGFR1    MARK4    RPS6KA2    CAMK1    FLT4    MAPK14
    BRAF    CDK7    HUNK    MAP4K5    PHKG1    TXK

    CAMKK2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1846 SNPs in CAMKK2 are shown (see all 1846)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0406124
    A colorectal adenocarcinoma sample4--see VAR_0406122 A T mis40--------
    VAR_0406114
    A lung neuroendocrine carcinoma sample4--see VAR_0406112 P L mis40--------
    rs116098771,2
    H--121472982(+) tttttA/Taattt 7 -- ds5001 int10--------
    rs116117621,2
    H--121472984(+) ttttaA/Tttttt 7 -- ds5001 int10--------
    rs1387816941,2
    C--121473001(+) TTTTT-/T/TA  
            
    AAGAG
    7 -- ds5001 int10--------
    rs342837011,2
    C--121473002(+) TTTTT-/AAGAGA 7 -- ds5001 int10--------
    rs798861211,2
    C--121473002(+) TTTTTA/TAGAGA 7 -- ds5001 int10--------
    rs71361061,2
    C,F,A--121473120(+) cggccG/Agcacc 7 -- ds5001 int13Minor allele frequency- A:0.11NA WA 240
    rs1394091671,2
    --121473141(+) ACCCAC/GTCACA 7 -- ds5001 int10--------
    rs108498611,2
    C,F,A,H--121473159(+) CTGGCG/ACTACT 7 -- ds5001 int18Minor allele frequency- A:0.23NS EA CSA WA NA 750

    HapMap Linkage Disequilibrium report for CAMKK2 (121675495 - 121736111 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CAMKK2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2746484CNV Deletion23290073
    esv2660506CNV Deletion23128226
    esv2746485CNV Deletion23290073
    esv1008629CNV Insertion20482838
    nsv513372CNV Insertion21212237
    nsv455731CNV Loss19166990
    nsv899564CNV Loss21882294
    nsv521928CNV Gain19592680
    nsv899565CNV Gain+Loss21882294


    Human Gene Mutation Database (HGMD): CAMKK2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CAMKK2
    DNA2.0 Custom Variant and Variant Library Synthesis for CAMKK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 615002    OMIM disorders: --

    14 diseases for CAMKK2:    About MalaCards
    anxiety disorder    mantle cell lymphoma    amyotrophic lateral sclerosis    lateral sclerosis
    cervical cancer    endotheliitis    schizophrenia    cervicitis
    hypoxia    neuronitis    thyroiditis    lung cancer
    breast cancer    prostatitis


    CAMKK2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CAMKK2
    Human Genome Epidemiology (HuGE) Navigator: CAMKK2 (4 documents)

    Export disorders for CAMKK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CAMKK2 gene, integrated from 9 sources (see all 106):
    (articles sorted by number of sources associating them with CAMKK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase. (PubMed id 9662074)1, 2, 3, 9 Hsu L.-S.... Chen J.-Y. (1998)
    2. Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity. (PubMed id 11395482)1, 2, 9 Hsu L.-S.... Chen J.-Y. (2001)
    3. Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders. (PubMed id 17197037)1, 4, 9 Erhardt A....Holsboer F. (2007)
    4. Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta. (PubMed id 9822657)1, 2, 9 Anderson K.A.... Means A.R. (1998)
    5. Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells. (PubMed id 12935886)1, 2, 9 Ishikawa Y....Kobayashi R. (2003)
    6. Differential effects of PKA-controlled CaMKK2 variants on neuronal differentiation. (PubMed id 21957496)1, 2 Cao W....Xie J. (2011)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    8. Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder. (PubMed id 16673375)1, 4 Barden N....Muller-Myhsok B. (2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10645 HGNC: 1470 AceView: CAMKK2 Ensembl:ENSG00000110931 euGenes: HUgn10645
    ECgene: CAMKK2 Kegg: 10645 H-InvDB: CAMKK2

    (According to HUGE)
    About This Section
    HUGE: KIAA0787

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CAMKK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CAMKK2 gene:
    Search GeneIP for patents involving CAMKK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CAMKK2
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CAMKK2   OriGene RNAi products in human, mouse, rat for CAMKK2  
     OriGene qPCR primer pairs and template standards for CAMKK2   OriGene Protein Over-expression Lysate for CAMKK2  
     OriGene MassSpec something-or-other for CAMKK2   OriGene clones in human, mouse for CAMKK2  
     OriGene qSTAR qPCR primer pairs in human, mouse for CAMKK2   OriGene Purified Protein for CAMKK2  
     OriGene ORF clones in mouse, rat for CAMKK2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CAMKK2   OriGene Custom Protein Services for CAMKK2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CAMKK2
     QIAGEN SeqTarget long-range PCR primers for resequencing CAMKK2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAMKK2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAMKK2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAMKK2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAMKK2
     GenScript Custom Purified and Recombinant Proteins Services for CAMKK2 GenScript cDNA clones with any tag delivered in your preferred vector for CAMKK2
     GenScript Custom Assay Services for CAMKK2 GenScript Custom Superior Antibodies Services for CAMKK2
     GenScript Custom overexpressing Cell Line Services for CAMKK2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for CAMKK2 

     Regulatory tfbs in CAMKK2 promoter
     Search Chromatin IP Primers for CAMKK2
     RT2 qPCR Primer Assay in human, mouse, rat CAMKK2
     GNC Network for CAMKK2
     SABiosciences PCR Arrays including human, mouse, rat CAMKK2
     Tocris compounds for CAMKK2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs for CAMKK2
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CAMKK2 antibodies
     CAMKK2 proteins
     CAMKK2 lysates
     Antibodies for CAMKK2
     See all of Abcam's Antibodies, Kits and Proteins for CAMKK2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CAMKK2
     Antibodies for CAMKK2
     ELISAs for CAMKK2
     CLIAs for CAMKK2
     Search LifeMap BioReagents cell lines for CAMKK2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMKK2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CAMKK2
     SwitchGear Promoter luciferase reporter plasmids for CAMKK2
     ThermoFisher Antibody for CAMKK2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMKK2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CAMKK2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CAMKK2
    Customized:
     lentivirus for stable overexpression of CAMKK2
     lentivirus expression plasmids for stable overexpression of CAMKK2
     adenovirus for overexpression of CAMKK2
     LSBio Antibodies in human, mouse, rat for CAMKK2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CAMKK2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4