Aliases for CAMKK1 Gene
Aliases for CAMKK1 Gene
External Ids for CAMKK1 Gene
- HGNC: 1469
- Entrez Gene: 84254
- Ensembl: ENSG00000004660
- OMIM: 611411
- UniProtKB: Q8N5S9
Previous GeneCards Identifiers for CAMKK1 Gene
- GC17M004076
- GC17M003714
- GC17M003970
- GC17M003710
- GC17M003763
Summaries for CAMKK1 Gene
-
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for CAMKK1 Gene
CAMKK1 (Calcium/Calmodulin Dependent Protein Kinase Kinase 1) is a Protein Coding gene. Among its related pathways are MAPK-Erk Pathway and Development ERBB-family signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CAMKK2.
UniProtKB/Swiss-Prot for CAMKK1 Gene
-
Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.
-
Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through autoinhibition, which can be relieved by increases in Ca2+ levels.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMKK1 Gene
Genomics for CAMKK1 Gene
Regulatory Elements for CAMKK1 Gene
Enhancers for CAMKK1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CAMKK1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CAMKK1 gene promoter:
Regulatory Element Products
Genomic Location for CAMKK1 Gene
- Chromosome:
- 17
- Start:
- 3,860,315 bp from pter
- End:
- 3,894,891 bp from pter
- Size:
- 34,577 bases
- Orientation:
- Minus strand
Genomic View for CAMKK1 Gene
Genes around CAMKK1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p13.2 by Ensembl
- 17p13.2 by Entrez Gene
- 17p13.2 by HGNC
CAMKK1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CAMKK1 Gene
Proteins for CAMKK1 Gene
-
Protein details for CAMKK1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N5S9-KKCC1_HUMAN
- Recommended name:
- Calcium/calmodulin-dependent protein kinase kinase 1
- Protein Accession:
- Q8N5S9
- Q9BQH3
Protein attributes for CAMKK1 Gene
- Size:
- 505 amino acids
- Molecular mass:
- 55735 Da
- Quaternary structure:
-
- Interacts with CAMK4 and calmodulin.
Protein Expression for CAMKK1 Gene
Selected DME Specific Peptides for CAMKK1 Gene
- Q8N5S9:
-
- GTPAFMAPE
- DGHVKIADFG
Post-translational modifications for CAMKK1 Gene
- Appears to be autophosphorylated in a Ca(2+)/calmodulin-dependent manner. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca(2+)/calmodulin. In vitro, phosphorylated by CAMK1 and CAMK4 (By similarity).
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for CAMKK1 Gene
Antibody Products
- R&D Systems Antibodies for CAMKK1 (CaMKK alpha)
-
Custom Antibody ServicesOriGene Antibodies for CAMKK1
- Novus Biologicals Antibodies for CAMKK1
-
Abcam antibodies for CAMKK1
- Invitrogen Antibodies for CAMKK1
- antibodies-online Antibodies for CAMKK1: See all 60
- Search GeneTex for Antibodies for CAMKK1
-
Santa Cruz Biotechnology (SCBT) Antibodies for CAMKK1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CAMKK1
- Origene Custom Protein Services for CAMKK1
- antibodies-online Proteins for CAMKK1: See all 10
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CAMKK1
-
Abcam proteins for CAMKK1
Assay Products
- antibodies-online Kits for CAMKK1: See all 4
Domains & Families for CAMKK1 Gene
Gene Families for CAMKK1 Gene
Protein Domains for CAMKK1 Gene
Suggested Antigen Peptide Sequences for CAMKK1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8N5S9UniProtKB/Swiss-Prot:
KKCC1_HUMAN :- The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition.
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
- Domain:
-
- The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition.
- The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates.
- Family:
-
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Function for CAMKK1 Gene
Molecular function for CAMKK1 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by Ca(2+)/calmodulin. Binding of calmodulin may relieve intrasteric autoinhibition. Partially inhibited upon phosphorylation by PRCAKA/PKA (By similarity). May be regulated through phosphorylation by CAMK1 and CAMK4.
- UniProtKB/Swiss-Prot Function:
- Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.
Enzyme Numbers (IUBMB) for CAMKK1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IEA | -- |
| GO:0004683 | calmodulin-dependent protein kinase activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 18242179 |
| GO:0005516 | calmodulin binding | IBA,IEA | -- |
Phenotypes for CAMKK1 Gene
- MGI mutant phenotypes for CAMKK1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CAMKK1:
-
- Increased transferrin (TF) endocytosis
- Increased G1 DNA content
- Decreased viability
- Decreased IL-8 secretion
- Decreased cell migration
- Decreased shRNA abundance
- Synthetic lethal with vaccinia virus (VACV) infection
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased cell viability after pRB stimulation
- Increased cell migration
- Decreased IL-13 protein expression
- Decreased Hepatitis C Virus pseudoparticles (HCVpp
- Increased senescence-associated beta-galactosidase protein expression after pRB stimulation
- Paclitaxel antagonistic effect
- Decreased viability in Von Hippel-Lindau (VHL) (-/-) cell line
Animal Models for CAMKK1 Gene
- MGI Knock Outs for CAMKK1:
-
- Camkk1 tm1Tch
Animal Model Products
-
Taconic Biosciences Mouse Models for CAMKK1
- Cyagen custom Knockout/knockin (KOKI) mouse models for CAMKK1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CAMKK1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CAMKK1 gene
- Search ViGene Biosciences for CAMKK1
CRISPR Products
-
OriGene CRISPR knockouts for CAMKK1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CAMKK1
- GenScript: Design CRISPR guide RNA sequences for CAMKK1
miRNA for CAMKK1 Gene
- miRTarBase miRNAs that target CAMKK1
miRNA Products
- Search ViGene Biosciences for CAMKK1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CAMKK1
- Browse OriGene Inhibitory RNA Products For CAMKK1
-
ViGene Biosciences ready-to-package AAV shRNAs for CAMKK1 gene
Clone Products
- Sino Biological Human cDNA Clone for CAMKK1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CAMKK1
- VectorBuilder custom plasmid, inducible vectors for CAMKK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CAMKK1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CAMKK1
-
ViGene Biosciences adenoviral particle packaged cDNA for CAMKK1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CAMKK1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CAMKK1 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAMKK1 Gene
Localization for CAMKK1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CAMKK1 Gene
- Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 4 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA,IEA | -- |
| GO:0005737 | cytoplasm | IEA,IBA | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for CAMKK1 Gene
Pathways by source for CAMKK1 Gene
4 Sino Biological pathways for CAMKK1 Gene
1 BioSystems pathway for CAMKK1 Gene
6 Reactome pathways for CAMKK1 Gene
1 KEGG pathway for CAMKK1 Gene
4 GeneGo (Thomson Reuters) pathways for CAMKK1 Gene
2 R&D Systems pathways for CAMKK1 Gene
2 Qiagen pathways for CAMKK1 Gene
Interacting Proteins for CAMKK1 Gene
Selected Interacting proteins:
Q8N5S9-KKCC1_HUMAN
ENSP00000158166
for CAMKK1 Gene via
IID
STRING
UniProtKB
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0016310 | phosphorylation | IEA | -- |
| GO:0018105 | peptidyl-serine phosphorylation | IBA | -- |
| GO:0018107 | peptidyl-threonine phosphorylation | IBA | -- |
| GO:0035556 | intracellular signal transduction | IBA | -- |
Drugs & Compounds for CAMKK1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Adenosine triphosphate | Approved | Nutra | 0 | |||
| calcium | Nutra | 0 | ||||
| A 484954 | Pharma | EEF2K Inhibitor, CaM kinase III (eEF-2 kinase) inhibitor | 0 | |||
| KN-93 Phosphate | Pharma | CaM kinase II inhibitor, water soluble and cell permeable, CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278). | 0 | |||
| STO-609 acetate | Pharma | Selective CaM kinase kinase inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
||
| Autocamtide-2-related inhibitory peptide, myristoylated |
|
201422-04-0 |
|
|
||
| KN 93 |
|
139298-40-1 |
|
|
(5) Tocris Compounds for CAMKK1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| A 484954 | CaM kinase III (eEF-2 kinase) inhibitor | 142557-61-7 |
| Autocamtide-2-related inhibitory peptide, myristoylated | CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptide | 201422-04-0 |
| KN 93 | CaM kinase II inhibitor; also K+ channel blocker (KV) | 139298-40-1 |
| KN 93 phosphate | CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278). | 1188890-41-6 |
| STO-609 acetate | Selective CaM kinase kinase inhibitor | 1173022-21-3 |
Transcripts for CAMKK1 Gene
mRNA/cDNA for CAMKK1 Gene
- (13) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (76) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CAMKK1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CAMKK1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CAMKK1
- GenScript: Design CRISPR guide RNA sequences for CAMKK1
miRNA Products
- Search ViGene Biosciences for CAMKK1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CAMKK1
- Browse OriGene Inhibitory RNA Products For CAMKK1
-
ViGene Biosciences ready-to-package AAV shRNAs for CAMKK1 gene
Clone Products
- Sino Biological Human cDNA Clone for CAMKK1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CAMKK1
- VectorBuilder custom plasmid, inducible vectors for CAMKK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CAMKK1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CAMKK1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
mRNA differential expression in normal tissues according to GTEx for CAMKK1 Gene
This gene is overexpressed in Brain - Cortex (x5.2) and Brain - Frontal Cortex (BA9) (x4.5).
This gene is overexpressed in Lung (51.2) and Frontal cortex (7.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CAMKK1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CAMKK1 Gene:
CAMKK1SOURCE GeneReport for Unigene cluster for CAMKK1 Gene:
Hs.8417Evidence on tissue expression from TISSUES for CAMKK1 Gene
- Nervous system(4.4)
- Liver(4)
Primer Products
-
OriGene qPCR primer pairs and template standards for CAMKK1
-
OriGene qPCR primer pairs for CAMKK1
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAMKK1 Gene
Orthologs for CAMKK1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CAMKK1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CAMKK1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CAMKK1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Camkk1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Camkk1 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | CAMKK1 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | CAMKK1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CAMKK1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CAMKK1 35 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | CaM-KK 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | camkk1 34 35 |
|
||
| CAMKK1 (1 of 2) 35 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG17698 34 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | ckk-1 35 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TOS3 35 |
|
ManyToMany | |
| SAK1 35 37 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for CAMKK1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for CAMKK1 Gene
(21) SIMAP similar genes for CAMKK1 Gene using alignment to 3 proteins:
Variants for CAMKK1 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000002416 | -- | 3,879,303(+) | CAGAA(A/G)CAGCC | intron-variant | |
| rs1000119243 | -- | 3,887,561(+) | TGCGG(C/G)TGTGG | intron-variant, upstream-variant-2KB | |
| rs1000205315 | -- | 3,893,083(+) | GGGCA(C/G)CGCTC | intron-variant, upstream-variant-2KB | |
| rs1000227626 | -- | 3,860,819(+) | ACAGG(C/T)GCGGA | utr-variant-3-prime | |
| rs1000232169 | -- | 3,874,137(+) | AACAC(-/CAGA)CAAAT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv405e201 | CNV | deletion | 23290073 |
| dgv406e201 | CNV | deletion | 23290073 |
| esv1243821 | CNV | deletion | 17803354 |
| esv2150356 | CNV | deletion | 18987734 |
| esv2662233 | CNV | deletion | 23128226 |
| esv2662801 | CNV | deletion | 23128226 |
| esv2715534 | CNV | deletion | 23290073 |
| esv2715535 | CNV | deletion | 23290073 |
| esv2761940 | CNV | gain | 21179565 |
| esv28673 | CNV | gain | 19812545 |
| esv3438240 | CNV | insertion | 20981092 |
| esv3554025 | CNV | deletion | 23714750 |
| esv3639757 | CNV | loss | 21293372 |
| esv3639758 | CNV | gain | 21293372 |
| esv3639759 | CNV | loss | 21293372 |
| esv992121 | CNV | deletion | 20482838 |
| esv998088 | CNV | deletion | 20482838 |
| nsv1055740 | CNV | gain | 25217958 |
| nsv1065489 | CNV | gain | 25217958 |
| nsv1070379 | CNV | deletion | 25765185 |
| nsv1135824 | CNV | deletion | 24896259 |
| nsv469791 | CNV | loss | 16826518 |
| nsv512473 | CNV | loss | 21212237 |
| nsv521340 | CNV | gain | 19592680 |
| nsv524296 | CNV | loss | 19592680 |
| nsv526126 | CNV | loss | 19592680 |
| nsv820660 | CNV | deletion | 20802225 |
| nsv833343 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
9.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
12.43;
94.29% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CAMKK1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMKK1 Gene
Disorders for CAMKK1 Gene
Relevant External Links for CAMKK1
No disorders were found for CAMKK1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAMKK1 Gene
Publications for CAMKK1 Gene
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
- A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu C.Y. … Christiani D.C. (Carcinogenesis 2010) 3 46 64
- International Lung Cancer Consortium: coordinated association study of 10 potential lung cancer susceptibility variants. (PMID: 20106900) Truong T. … Hung R.J. (Carcinogenesis 2010) 3 46 64
- Genome-wide and candidate gene association study of cigarette smoking behaviors. (PMID: 19247474) Caporaso N. … Bergen A.W. (PLoS ONE 2009) 3 46 64
- Variants in the GH-IGF axis confer susceptibility to lung cancer. (PMID: 16741161) Rudd M.F. … Houlston R.S. (Genome Res. 2006) 3 46 64
Products for CAMKK1 Gene
- R&D Systems Antibodies for CAMKK1 (CaMKK alpha)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CAMKK1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CAMKK1
- Origene Custom Protein Services for CAMKK1
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CAMKK1
- Browse OriGene Inhibitory RNA Products For CAMKK1
- OriGene qPCR primer pairs and template standards for CAMKK1
- OriGene qPCR primer pairs for CAMKK1
- OriGene CRISPR knockouts for CAMKK1
- OriGene ORF clones in human for CAMKK1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CAMKK1
- GenScript: Next-day shipping cDNA ORF clone for CAMKK1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CAMKK1
- GenScript Custom Assay Services for CAMKK1
- GenScript Custom overexpressing Cell Line Services for CAMKK1
- GenScript: Design CRISPR guide RNA sequences for CAMKK1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CAMKK1
- Sino Biological Human cDNA Clone for CAMKK1
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for CAMKK1
- Novus Biologicals proteins and lysates for CAMKK1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for CAMKK1
- Abcam proteins for CAMKK1
- Search for Assays for CAMKK1 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Taconic Biosciences Mouse Models for CAMKK1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Addgene plasmids for CAMKK1
- antibodies-online Antibodies for CAMKK1: See all 60
- antibodies-online Kits for CAMKK1: See all 4
- antibodies-online Proteins for CAMKK1: See all 10
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for CAMKK1
- Search GeneTex for Proteins for CAMKK1
- ViGene Biosciences adenoviral particle packaged cDNA for CAMKK1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CAMKK1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CAMKK1 gene
- Search ViGene Biosciences for CAMKK1
- Santa Cruz Biotechnology (SCBT) Antibodies for CAMKK1
- Search Santa Cruz Biotechnology (SCBT) for CAMKK1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CAMKK1
- Horizon Cell Lines for CAMKK1
- Cyagen custom Knockout/knockin (KOKI) mouse models for CAMKK1
- VectorBuilder custom plasmid, inducible vectors for CAMKK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CAMKK1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CAMKK1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer