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Aliases for CAMKK1 Gene

Aliases for CAMKK1 Gene

  • Calcium/Calmodulin Dependent Protein Kinase Kinase 1 2 3 5
  • Calcium/Calmodulin-Dependent Protein Kinase Kinase Alpha 2 3 4
  • Calcium/Calmodulin-Dependent Protein Kinase Kinase 1, Alpha 2 3
  • CaM-Kinase Kinase Alpha 3 4
  • CaM-Kinase IV Kinase 3 4
  • CaM-Kinase Kinase 1 3 4
  • CaM-KK Alpha 3 4
  • CaM-KK 1 3 4
  • CaMKK 1 3 4
  • CAMKKA 3 4
  • Calcium/Calmodulin-Dependent Protein Kinase Kinase 1 3
  • CAMKK Alpha Protein 3
  • EC 2.7.11.17 4
  • CaMKK Alpha 4
  • EC 2.7.11 61

External Ids for CAMKK1 Gene

Previous GeneCards Identifiers for CAMKK1 Gene

  • GC17M004076
  • GC17M003714
  • GC17M003970
  • GC17M003710
  • GC17M003763

Summaries for CAMKK1 Gene

Entrez Gene Summary for CAMKK1 Gene

  • The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAMKK1 Gene

CAMKK1 (Calcium/Calmodulin Dependent Protein Kinase Kinase 1) is a Protein Coding gene. Among its related pathways are MAPK Signaling: Oxidative Stress Pathway and Activation of NMDA receptor upon glutamate binding and postsynaptic events. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CAMKK2.

UniProtKB/Swiss-Prot for CAMKK1 Gene

  • Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.

Tocris Summary for CAMKK1 Gene

  • Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through autoinhibition, which can be relieved by increases in Ca2+ levels.

Gene Wiki entry for CAMKK1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMKK1 Gene

Genomics for CAMKK1 Gene

Regulatory Elements for CAMKK1 Gene

Enhancers for CAMKK1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CAMKK1 on UCSC Golden Path with GeneCards custom track

Promoters for CAMKK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CAMKK1 Gene

Chromosome:
17
Start:
3,860,315 bp from pter
End:
3,894,891 bp from pter
Size:
34,577 bases
Orientation:
Minus strand

Genomic View for CAMKK1 Gene

Genes around CAMKK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAMKK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAMKK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMKK1 Gene

Proteins for CAMKK1 Gene

  • Protein details for CAMKK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5S9-KKCC1_HUMAN
    Recommended name:
    Calcium/calmodulin-dependent protein kinase kinase 1
    Protein Accession:
    Q8N5S9
    Secondary Accessions:
    • Q9BQH3

    Protein attributes for CAMKK1 Gene

    Size:
    505 amino acids
    Molecular mass:
    55735 Da
    Quaternary structure:
    • Interacts with CAMK4 and calmodulin.

    Alternative splice isoforms for CAMKK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAMKK1 Gene

Selected DME Specific Peptides for CAMKK1 Gene

Post-translational modifications for CAMKK1 Gene

  • Appears to be autophosphorylated in a Ca(2+)/calmodulin-dependent manner. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca(2+)/calmodulin. In vitro, phosphorylated by CAMK1 and CAMK4 (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAMKK1 Gene

Antibody Products

  • Abcam antibodies for CaMKK

Domains & Families for CAMKK1 Gene

Gene Families for CAMKK1 Gene

Suggested Antigen Peptide Sequences for CAMKK1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N5S9

UniProtKB/Swiss-Prot:

KKCC1_HUMAN :
  • The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Domain:
  • The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition.
  • The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with CAMKK1: view

Function for CAMKK1 Gene

Molecular function for CAMKK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by Ca(2+)/calmodulin. Binding of calmodulin may relieve intrasteric autoinhibition. Partially inhibited upon phosphorylation by PRCAKA/PKA (By similarity). May be regulated through phosphorylation by CAMK1 and CAMK4.
UniProtKB/Swiss-Prot Function:
Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.

Enzyme Numbers (IUBMB) for CAMKK1 Gene

Gene Ontology (GO) - Molecular Function for CAMKK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004683 calmodulin-dependent protein kinase activity TAS --
GO:0005515 protein binding IPI 18242179
GO:0005516 calmodulin binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CAMKK1: view
genes like me logo Genes that share phenotypes with CAMKK1: view

Animal Models for CAMKK1 Gene

MGI Knock Outs for CAMKK1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CAMKK1

CRISPR Products

miRNA for CAMKK1 Gene

miRTarBase miRNAs that target CAMKK1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAMKK1 Gene

Localization for CAMKK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMKK1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAMKK1 Gene COMPARTMENTS Subcellular localization image for CAMKK1 gene
Compartment Confidence
cytosol 5
nucleus 4

Gene Ontology (GO) - Cellular Components for CAMKK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CAMKK1: view

Pathways & Interactions for CAMKK1 Gene

genes like me logo Genes that share pathways with CAMKK1: view

SIGNOR curated interactions for CAMKK1 Gene

Activates:

Gene Ontology (GO) - Biological Process for CAMKK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0032147 activation of protein kinase activity IEA --
genes like me logo Genes that share ontologies with CAMKK1: view

Drugs & Compounds for CAMKK1 Gene

(5) Drugs for CAMKK1 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
calcium Nutra 0
A 484954 Pharma EEF2K Inhibitor, CaM kinase III (eEF-2 kinase) inhibitor 0
KN-93 Phosphate Pharma CaM kinase II inhibitor, water soluble and cell permeable, CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278). 0
STO-609 acetate Pharma Selective CaM kinase kinase inhibitor 0

(3) Additional Compounds for CAMKK1 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Autocamtide-2-related inhibitory peptide, myristoylated
201422-04-0
KN 93
139298-40-1

(5) Tocris Compounds for CAMKK1 Gene

Compound Action Cas Number
A 484954 CaM kinase III (eEF-2 kinase) inhibitor 142557-61-7
Autocamtide-2-related inhibitory peptide, myristoylated CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptide 201422-04-0
KN 93 CaM kinase II inhibitor; also K+ channel blocker (KV) 139298-40-1
KN 93 phosphate CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278). 1188890-41-6
STO-609 acetate Selective CaM kinase kinase inhibitor 1173022-21-3
genes like me logo Genes that share compounds with CAMKK1: view

Transcripts for CAMKK1 Gene

Unigene Clusters for CAMKK1 Gene

Calcium/calmodulin-dependent protein kinase kinase 1, alpha:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAMKK1 Gene

No ASD Table

Relevant External Links for CAMKK1 Gene

GeneLoc Exon Structure for
CAMKK1
ECgene alternative splicing isoforms for
CAMKK1

Expression for CAMKK1 Gene

mRNA expression in normal human tissues for CAMKK1 Gene

mRNA differential expression in normal tissues according to GTEx for CAMKK1 Gene

This gene is overexpressed in Brain - Cortex (x5.2) and Brain - Frontal Cortex (BA9) (x4.5).

Protein differential expression in normal tissues from HIPED for CAMKK1 Gene

This gene is overexpressed in Lung (51.2) and Frontal cortex (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CAMKK1 Gene



Protein tissue co-expression partners for CAMKK1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CAMKK1 Gene:

CAMKK1

SOURCE GeneReport for Unigene cluster for CAMKK1 Gene:

Hs.8417
genes like me logo Genes that share expression patterns with CAMKK1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CAMKK1 Gene

Orthologs for CAMKK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CAMKK1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CAMKK1 34
  • 90.03 (n)
  • 93.86 (a)
CAMKK1 35
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAMKK1 34
  • 89.83 (n)
  • 93.07 (a)
CAMKK1 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Camkk1 34
  • 88.84 (n)
  • 93.47 (a)
Camkk1 16
Camkk1 35
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CAMKK1 34
  • 97.56 (n)
  • 97.43 (a)
CAMKK1 35
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Camkk1 34
  • 88.65 (n)
  • 93.66 (a)
oppossum
(Monodelphis domestica)
Mammalia CAMKK1 35
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAMKK1 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves CAMKK1 34
  • 70.66 (n)
  • 76.42 (a)
CAMKK1 35
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAMKK1 35
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia CaM-KK 34
zebrafish
(Danio rerio)
Actinopterygii camkk1 34
  • 70.58 (n)
  • 74.18 (a)
camkk1 35
  • 65 (a)
OneToMany
CAMKK1 (1 of 2) 35
  • 60 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17698 34
  • 50.63 (n)
  • 50.47 (a)
CG17698 35
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ckk-1 35
  • 40 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAK1 35
  • 13 (a)
ManyToMany
TOS3 35
  • 21 (a)
ManyToMany
SAK1 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 49 (a)
OneToMany
Species where no ortholog for CAMKK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CAMKK1 Gene

ENSEMBL:
Gene Tree for CAMKK1 (if available)
TreeFam:
Gene Tree for CAMKK1 (if available)

Paralogs for CAMKK1 Gene

Paralogs for CAMKK1 Gene

genes like me logo Genes that share paralogs with CAMKK1: view

Variants for CAMKK1 Gene

Sequence variations from dbSNP and Humsavar for CAMKK1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs7214723 - 3,872,554(+) CTCAC(C/T)CCTCA reference, missense
rs9135 -- 3,860,639(-) CCCGA(A/G)GCTTA utr-variant-3-prime
rs177985 -- 3,862,305(-) CCTCT(C/G)TCCCT intron-variant
rs218705 -- 3,863,086(-) GAAAA(C/T)TAGAT intron-variant
rs218706 -- 3,862,874(-) GGATC(A/G)CTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAMKK1 Gene

Variant ID Type Subtype PubMed ID
dgv405e201 CNV deletion 23290073
dgv406e201 CNV deletion 23290073
esv1243821 CNV deletion 17803354
esv2150356 CNV deletion 18987734
esv2662233 CNV deletion 23128226
esv2662801 CNV deletion 23128226
esv2715534 CNV deletion 23290073
esv2715535 CNV deletion 23290073
esv2761940 CNV gain 21179565
esv28673 CNV gain 19812545
esv3438240 CNV insertion 20981092
esv3554025 CNV deletion 23714750
esv3639757 CNV loss 21293372
esv3639758 CNV gain 21293372
esv3639759 CNV loss 21293372
esv992121 CNV deletion 20482838
esv998088 CNV deletion 20482838
nsv1055740 CNV gain 25217958
nsv1065489 CNV gain 25217958
nsv1070379 CNV deletion 25765185
nsv1135824 CNV deletion 24896259
nsv469791 CNV loss 16826518
nsv512473 CNV loss 21212237
nsv521340 CNV gain 19592680
nsv524296 CNV loss 19592680
nsv526126 CNV loss 19592680
nsv820660 CNV deletion 20802225
nsv833343 CNV loss 17160897

Variation tolerance for CAMKK1 Gene

Residual Variation Intolerance Score: 9.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.43; 94.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAMKK1 Gene

Human Gene Mutation Database (HGMD)
CAMKK1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAMKK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMKK1 Gene

Disorders for CAMKK1 Gene

Relevant External Links for CAMKK1

Genetic Association Database (GAD)
CAMKK1
Human Genome Epidemiology (HuGE) Navigator
CAMKK1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAMKK1

No disorders were found for CAMKK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAMKK1 Gene

Publications for CAMKK1 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 65
  2. International Lung Cancer Consortium: coordinated association study of 10 potential lung cancer susceptibility variants. (PMID: 20106900) Truong T. … Hung R.J. (Carcinogenesis 2010) 3 46 65
  3. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu C.Y. … Christiani D.C. (Carcinogenesis 2010) 3 46 65
  4. Genome-wide and candidate gene association study of cigarette smoking behaviors. (PMID: 19247474) Caporaso N. … Bergen A.W. (PLoS ONE 2009) 3 46 65
  5. Variants in the GH-IGF axis confer susceptibility to lung cancer. (PMID: 16741161) Rudd M.F. … Houlston R.S. (Genome Res. 2006) 3 46 65

Products for CAMKK1 Gene

Sources for CAMKK1 Gene

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