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Aliases for CAMKK1 Gene

Aliases for CAMKK1 Gene

  • Calcium/Calmodulin-Dependent Protein Kinase Kinase 1, Alpha 2 3
  • Calcium/Calmodulin-Dependent Protein Kinase Kinase Alpha 3 4
  • CaM-Kinase Kinase Alpha 3 4
  • CaM-Kinase IV Kinase 3 4
  • CaM-Kinase Kinase 1 3 4
  • CaM-KK Alpha 3 4
  • CaM-KK 1 3 4
  • CaMKK 1 3 4
  • CAMKKA 3 4
  • Calcium/Calmodulin-Dependent Protein Kinase Kinase 1 3
  • CAMKK Alpha Protein 3
  • EC 4
  • CaMKK Alpha 4
  • EC 2.7.11 64

External Ids for CAMKK1 Gene

Summaries for CAMKK1 Gene

Entrez Gene Summary for CAMKK1 Gene

  • The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAMKK1 Gene

CAMKK1 (Calcium/Calmodulin-Dependent Protein Kinase Kinase 1, Alpha) is a Protein Coding gene. Among its related pathways are CREB Pathway and Ca-dependent events. GO annotations related to this gene include calmodulin binding and calmodulin-dependent protein kinase activity. An important paralog of this gene is STK11.

UniProtKB/Swiss-Prot for CAMKK1 Gene

  • Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.

Tocris Summary for CAMKK1 Gene

  • Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through autoinhibition. Increases in Ca2+ levels allows calmodulin to relieve this autoinhibition and activate the kinase activity. There are two main classes of CaMKs; mulitfunctional CaMKs (CaMKK, CaMKI, CaMKII and CaMKIV) which have multiple downstream targets and substrate-specific CaMKs (CaMKIII) which have only one known downstream target. All CaMKs, with the exception of CaMKII, exist as monomers and most are expressed ubiquitously. Some subtypes display specific distributions, for example, CaMKIVbeta is expressed exclusively in cerebellar granule cells. CaMKs have numerous cellular functions and they influence processes as diverse as gene transcription, cell survival, apoptosis, cytoskeletal re-organization and learning and memory.

Gene Wiki entry for CAMKK1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMKK1 Gene

Genomics for CAMKK1 Gene

Genomic Location for CAMKK1 Gene

3,860,315 bp from pter
3,894,891 bp from pter
34,577 bases
Minus strand

Genomic View for CAMKK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAMKK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMKK1 Gene

Regulatory Elements for CAMKK1 Gene

Proteins for CAMKK1 Gene

  • Protein details for CAMKK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcium/calmodulin-dependent protein kinase kinase 1
    Protein Accession:
    Secondary Accessions:
    • Q9BQH3

    Protein attributes for CAMKK1 Gene

    505 amino acids
    Molecular mass:
    55735 Da
    Quaternary structure:
    • Interacts with CAMK4 and calmodulin.

    Alternative splice isoforms for CAMKK1 Gene


neXtProt entry for CAMKK1 Gene

Proteomics data for CAMKK1 Gene at MOPED

Selected DME Specific Peptides for CAMKK1 Gene

Post-translational modifications for CAMKK1 Gene

  • Appears to be autophosphorylated in a Ca(2+)/calmodulin-dependent manner. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca(2+)/calmodulin. In vitro, phosphorylated by CAMK1 and CAMK4 (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAMKK1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CAMKK1 Gene


  • The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition:
    • Q8N5S9
  • The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates.:
    • Q8N5S9
  • Contains 1 protein kinase domain.:
    • Q8N5S9
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.:
    • Q8N5S9
genes like me logo Genes that share domains with CAMKK1: view

Function for CAMKK1 Gene

Molecular function for CAMKK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by Ca(2+)/calmodulin. Binding of calmodulin may relieve intrasteric autoinhibition. Partially inhibited upon phosphorylation by PRCAKA/PKA (By similarity). May be regulated through phosphorylation by CAMK1 and CAMK4.
UniProtKB/Swiss-Prot Function: Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.

Enzyme Numbers (IUBMB) for CAMKK1 Gene

Gene Ontology (GO) - Molecular Function for CAMKK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity --
GO:0004683 calmodulin-dependent protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 18242179
genes like me logo Genes that share ontologies with CAMKK1: view

Phenotypes for CAMKK1 Gene

genes like me logo Genes that share phenotypes with CAMKK1: view

Animal Models for CAMKK1 Gene

MGI Knock Outs for CAMKK1:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for CAMKK1 Gene

Localization for CAMKK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMKK1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for CAMKK1 Gene COMPARTMENTS Subcellular localization image for CAMKK1 gene
Compartment Confidence
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for CAMKK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CAMKK1: view

Pathways for CAMKK1 Gene

genes like me logo Genes that share pathways with CAMKK1: view

Gene Ontology (GO) - Biological Process for CAMKK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007268 synaptic transmission TAS --
genes like me logo Genes that share ontologies with CAMKK1: view

Compounds for CAMKK1 Gene

(5) Tocris Compounds for CAMKK1 Gene

Compound Action Cas Number
A 484954 CaM kinase III (eEF-2 kinase) inhibitor [142557-61-7]
Arcyriaflavin A Potent cdk4/cyclin D1 and CaM Kinase II inhibitor. Antiviral agent (anti-HCMV) [118458-54-1]
KN-93 CaM kinase II inhibitor. Also K+ channel blocker (KV) [139298-40-1]
NH 125 CaM kinase III (eEF-2 kinase) inhibitor [278603-08-0]
STO-609 acetate Selective CaM kinase kinase inhibitor [52029-86-4]

(3) HMDB Compounds for CAMKK1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
  • Ca
genes like me logo Genes that share compounds with CAMKK1: view

Transcripts for CAMKK1 Gene

Unigene Clusters for CAMKK1 Gene

Calcium/calmodulin-dependent protein kinase kinase 1, alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAMKK1 Gene

No ASD Table

Relevant External Links for CAMKK1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CAMKK1 Gene

mRNA expression in normal human tissues for CAMKK1 Gene

mRNA differential expression in normal tissues according to GTEx for CAMKK1 Gene

This gene is overexpressed in Brain - Cortex (5.2) and Brain - Frontal Cortex (BA9) (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAMKK1 Gene

SOURCE GeneReport for Unigene cluster for CAMKK1 Gene Hs.8417

genes like me logo Genes that share expressions with CAMKK1: view

Orthologs for CAMKK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CAMKK1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CAMKK1 36
  • 97.56 (n)
  • 97.43 (a)
  • 94 (a)
(Bos Taurus)
Mammalia CAMKK1 36
  • 90.03 (n)
  • 93.86 (a)
  • 89 (a)
(Canis familiaris)
Mammalia CAMKK1 36
  • 89.83 (n)
  • 93.07 (a)
  • 89 (a)
(Mus musculus)
Mammalia Camkk1 36
  • 88.84 (n)
  • 93.47 (a)
Camkk1 16
Camkk1 37
  • 89 (a)
(Monodelphis domestica)
Mammalia CAMKK1 37
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia CAMKK1 37
  • 72 (a)
(Rattus norvegicus)
Mammalia Camkk1 36
  • 88.65 (n)
  • 93.66 (a)
(Gallus gallus)
Aves CAMKK1 36
  • 70.66 (n)
  • 76.42 (a)
  • 68 (a)
(Anolis carolinensis)
Reptilia CAMKK1 37
  • 73 (a)
African clawed frog
(Xenopus laevis)
Amphibia CaM-KK 36
(Danio rerio)
Actinopterygii camkk1 36
  • 70.58 (n)
  • 74.18 (a)
camkk1 37
  • 65 (a)
CAMKK1 (1 of 2) 37
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17698 36
  • 50.63 (n)
  • 50.47 (a)
CG17698 37
  • 29 (a)
(Caenorhabditis elegans)
Secernentea ckk-1 37
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SAK1 37
  • 13 (a)
SAK1 39
TOS3 37
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 49 (a)
Species with no ortholog for CAMKK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CAMKK1 Gene

Gene Tree for CAMKK1 (if available)
Gene Tree for CAMKK1 (if available)

Paralogs for CAMKK1 Gene

Paralogs for CAMKK1 Gene

Selected SIMAP similar genes for CAMKK1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CAMKK1: view

Variants for CAMKK1 Gene

Sequence variations from dbSNP and Humsavar for CAMKK1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs9135 -- 3,860,639(-) CCCGA(A/G)GCTTA utr-variant-3-prime
rs177985 -- 3,862,305(-) CCTCT(C/G)TCCCT intron-variant
rs218705 -- 3,863,086(-) GAAAA(C/T)TAGAT intron-variant
rs218706 -- 3,862,874(-) GGATC(A/G)CTTGA intron-variant
rs737360 -- 3,883,508(-) ACAGT(A/G)GTGAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CAMKK1 Gene

Variant ID Type Subtype PubMed ID
nsv907570 CNV Gain 21882294
nsv469791 CNV Complex 16826518
nsv833343 CNV Loss 17160897
nsv907572 CNV Loss 21882294
dgv3043n71 CNV Loss 21882294
dgv3044n71 CNV Loss 21882294
nsv526126 CNV Loss 19592680
nsv907578 CNV Loss 21882294
nsv907579 CNV Gain 21882294
esv2715534 CNV Deletion 23290073
nsv512473 CNV Loss 21212237
nsv820660 CNV Deletion 20802225
esv2150356 CNV Deletion 18987734
esv28673 CNV Gain 19812545
esv2715535 CNV Deletion 23290073
esv2662801 CNV Deletion 23128226
dgv442e201 CNV Deletion 23290073
dgv443e201 CNV Deletion 23290073
esv998088 CNV Deletion 20482838
esv1243821 CNV Deletion 17803354
esv992121 CNV Deletion 20482838
nsv907580 CNV Loss 21882294
esv2662233 CNV Deletion 23128226
nsv524296 CNV Loss 19592680
nsv521340 CNV Gain 19592680

Relevant External Links for CAMKK1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for CAMKK1 Gene

Relevant External Links for CAMKK1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CAMKK1: view

No data available for UniProtKB/Swiss-Prot for CAMKK1 Gene

Publications for CAMKK1 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  2. Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells. (PMID: 12935886) Ishikawa Y. … Kobayashi R. (FEBS Lett. 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Studies on the phosphorylation of protein kinase B by Ca(2+)/calmodulin-dependent protein kinases. (PMID: 10833263) Okuno S. … Fujisawa H. (J. Biochem. 2000) 3 23
  5. Regulation of Ca(2+)/calmodulin-dependent protein kinase kinase alpha by cAMP-dependent protein kinase: I. Biochemical analysis. (PMID: 11574070) Okuno S. … Fujisawa H. (J. Biochem. 2001) 3 23

Products for CAMKK1 Gene

Sources for CAMKK1 Gene

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