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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CAMKK1 Gene

protein-coding   GIFtS: 69
GCID: GC17M003763

Calcium/Calmodulin-Dependent Protein Kinase Kinase 1, Alpha

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Calcium/Calmodulin-Dependent Protein Kinase Kinase 1, Alpha1 2     CaMKK 12 3
Calcium/Calmodulin-Dependent Protein Kinase Kinase Alpha2 3     CAMKKA2 3
CaM-Kinase IV Kinase2 3     Calcium/Calmodulin-Dependent Protein Kinase Kinase 12
CaM-Kinase Kinase 12 3     CAMKK Alpha Protein2
CaM-Kinase Kinase Alpha2 3     EC 2.7.11.173
CaM-KK 12 3     CaMKK Alpha3
CaM-KK Alpha2 3     EC 2.7.118

External Ids:    HGNC: 14691   Entrez Gene: 842542   Ensembl: ENSG000000046607   OMIM: 6114115   UniProtKB: Q8N5S93   

Export aliases for CAMKK1 gene to outside databases

Previous GC identifers: GC17M004076 GC17M003714 GC17M003970 GC17M003710


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CAMKK1 Gene:
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the
Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the
calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have
been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CAMKK1 Gene: 
CAMKK1 (calcium/calmodulin-dependent protein kinase kinase 1, alpha) is a protein-coding gene. Diseases associated with CAMKK1 include esophageal adenocarcinoma, and lung cancer, and among its related super-pathways are Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell and Activation of NMDA receptor upon glutamate binding and postsynaptic events. GO annotations related to this gene include calmodulin binding and calmodulin-dependent protein kinase activity. An important paralog of this gene is CAMKK2.

UniProtKB/Swiss-Prot: KKCC1_HUMAN, Q8N5S9
Function: Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling
cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in
regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic
BAD/Bcl2-antagonist of cell death

summary for CAMKK1 Gene:
Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second
messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through
autoinhibition. Increases in Ca2+ levels allows calmodulin to relieve this autoinhibition and activate the
kinase activity. There are two main classes of CaMKs; mulitfunctional CaMKs (CaMKK, CaMKI, CaMKII and
CaMKIV) which have multiple downstream targets and substrate-specific CaMKs (CaMKIII) which have only one
known downstream target. All CaMKs, with the exception of CaMKII, exist as monomers and most are expressed
ubiquitously. Some subtypes display specific distributions, for example, CaMKIVbeta is expressed exclusively
in cerebellar granule cells. CaMKs have numerous cellular functions and they influence processes as diverse
as gene transcription, cell survival, apoptosis, cytoskeletal re-organization and learning and memory.

Gene Wiki entry for CAMKK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CAMKK1 gene promoter:
         ER-alpha   AREB6   Olf-1   Nkx5-1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCAMKK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CAMKK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAMKK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.2   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13.3

CAMKK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAMKK1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M003763:  view genomic region     (about GC identifiers)

Start:
3,763,609 bp from pter      End:
3,798,185 bp from pter
Size:
34,577 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KKCC1_HUMAN, Q8N5S9 (See protein sequence)
Recommended Name: Calcium/calmodulin-dependent protein kinase kinase 1  
Size: 505 amino acids; 55735 Da
Subunit: Interacts with CAMK4 and calmodulin (By similarity)
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
Secondary accessions: Q9BQH3
Alternative splicing: 2 isoforms:  Q8N5S9-1   Q8N5S9-2   

Explore the universe of human proteins at neXtProt for CAMKK1: NX_Q8N5S9

Explore proteomics data for CAMKK1 at MOPED 

Post-translational modifications:

  • UniProtKB: Appears to be autophosphorylated in a Ca(2+)/calmodulin-dependent manner. Phosphorylated at multiple sites by
    PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca(2+)/calmodulin. In vitro, phosphorylated by
    CAMK1 and CAMK4 (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N5S9

  • 2 DME Specific Peptides for CAMKK1 (Q8N5S9)
     GTPAFMAPE  DGHVKIADFG 

    CAMKK1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CAMKK1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_115670.1  NP_757343.1  NP_757344.2  

    ENSEMBL proteins: 
     ENSP00000371188   ENSP00000323118   ENSP00000158166   ENSP00000371190  
    Reactome Protein details: Q8N5S9
    Human Recombinant Protein Products for CAMKK1: 
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    OriGene Protein Over-expression Lysate for CAMKK1
    OriGene MassSpec for CAMKK1 
    OriGene Custom Protein Services for CAMKK1
    GenScript Purified and Recombinant Proteins for CAMKK1
    Novus Biologicals CAMKK1 Proteins
    Novus Biologicals CAMKK1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CAMKK1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--

    CAMKK1 for ontologies           About GeneDecksing



    CAMKK1 Antibody Products: 
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    Cloud-Clone Corp. Antibodies for CAMKK1 
    ThermoFisher Antibodies for CAMKK1
    LSBio Antibodies in human, mouse, rat for CAMKK1 

    Assay Products for CAMKK1: 
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    Cloud-Clone Corp. CLIAs for CAMKK1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: calcium/calmodulin-dependent protein kinase kinase 1, alpha 
    Meta subfamily

    5/6 InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q8N5S9

    ProtoNet protein and cluster: Q8N5S9

    UniProtKB/Swiss-Prot: KKCC1_HUMAN, Q8N5S9
    Domain: The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric
    autoinhibition
    Domain: The RP domain (arginine/proline-rich) is involved in the recognition of CAMKI and CAMK4 as substrates (By
    similarity)
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    CAMKK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KKCC1_HUMAN, Q8N5S9
    Function: Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling
    cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in
    regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic
    BAD/Bcl2-antagonist of cell death
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by Ca(2+)/calmodulin. Binding of calmodulin may relieve intrasteric autoinhibition.
    Partially inhibited upon phosphorylation by PRCAKA/PKA (By similarity). May be regulated through phosphorylation
    by CAMK1 and CAMK4

         Enzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.171

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004683calmodulin-dependent protein kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI18242179
         
    CAMKK1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CAMKK1:
     Increased G1 DNA content  Paclitaxel antagonistic effect 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Camkk1):
     behavior/neurological  nervous system  reproductive system 

    CAMKK1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Camkk1tm1Tch for CAMKK1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CAMKK1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CAMKK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAMKK1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAMKK1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAMKK1
    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate CAMKK1 (see all 41):
    hsa-miR-3194-5p hsa-miR-218 hsa-miR-650 hsa-miR-654-5p hsa-miR-2116 hsa-miR-3612 hsa-miR-181b hsa-miR-3690
    SwitchGear 3'UTR luciferase reporter plasmidCAMKK1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CAMKK1
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    Gene Editing
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    Clone
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    Sino Biological Human cDNA Clone for CAMKK1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAMKK1
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                         Customized lentivirus expression plasmids for stable overexpression of CAMKK1 

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    Search LifeMap BioReagents cell lines for CAMKK1
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMKK1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CAMKK1 About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.67
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    2Post NMDA receptor activation events
    Post NMDA receptor activation events0.89
    Activation of NMDA receptor upon glutamate binding and postsynaptic events0.89
    3Immune response Function of MEF2 in T lymphocytes
    Immune response Function of MEF2 in T lymphocytes0.90
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis0.38
    4Signal transduction IP3 signaling
    Signal transduction IP3 signaling0.92
    5CaMK IV-mediated phosphorylation of CREB
    CREB phosphorylation through the activation of CaMKK0.75

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for CAMKK1
        Signal transduction Calcium signaling
    Immune response Function of MEF2 in T lymphocytes
    Signal transduction IP3 signaling
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CAMKK1
        IP3 Pathway
    Dopamine-DARPP32 Feedback onto cAMP Pathway

    4 GeneGo (Thomson Reuters) Pathways for CAMKK1
        Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Immune response Function of MEF2 in T lymphocytes
    Signal transduction Calcium signaling
    Signal transduction IP3 signaling

    1 BioSystems Pathway for CAMKK1
        AMPK signaling

    1 Sino Biological Pathway for CAMKK1 
        EGFR Signaling Pathway

    5/6        Reactome Pathways for CAMKK1 (see all 6)
        Transmission across Chemical Synapses
    Activation of NMDA receptor upon glutamate binding and postsynaptic events
    Post NMDA receptor activation events
    Neuronal System
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell


    2         Kegg Pathways  (Kegg details for CAMKK1):
        Adipocytokine signaling pathway
    Alcoholism


    CAMKK1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CAMKK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/24 Interacting proteins for CAMKK1 (Q8N5S92, 3 ENSP000001581664) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAHQ049172, 3, ENSP000002489754MINT-6491259 MINT-6491287 MINT-6491322 MINT-6491274 MINT-6491300 I2D: score=2 STRING: ENSP00000248975
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    CAMK1Q140123, ENSP000002564604I2D: score=2 STRING: ENSP00000256460
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0007268synaptic transmission TAS--

    CAMKK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CAMKK1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for CAMKK1

    Compounds for CAMKK1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    NH 125CaM kinase III (eEF-2 kinase) inhibitor[278603-08-0]
    STO-609 acetateSelective CaM kinase kinase inhibitor[52029-86-4]
    A 484954CaM kinase III (eEF-2 kinase) inhibitor[142557-61-7]
    KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
    Arcyriaflavin APotent cdk4/cyclin D1 and CaM Kinase II inhibitor. Antiviral agent (anti-HCMV)[118458-54-1]

    3 HMDB Compounds for CAMKK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--

    Search CenterWatch for drugs/clinical trials and news about CAMKK1 / KKCC1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CAMKK1 gene (3 alternative transcripts): 
    NM_032294.2  NM_172206.1  NM_172207.2  

    Unigene Cluster for CAMKK1:

    Calcium/calmodulin-dependent protein kinase kinase 1, alpha
    Hs.8417  [show with all ESTs]
    Unigene Representative Sequence: AK128601
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381769(uc002fwt.3) ENST00000348335(uc002fwu.3) ENST00000158166(uc002fwv.3)
    ENST00000573483 ENST00000381771
    miRNA
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    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate CAMKK1 (see all 41):
    hsa-miR-3194-5p hsa-miR-218 hsa-miR-650 hsa-miR-654-5p hsa-miR-2116 hsa-miR-3612 hsa-miR-181b hsa-miR-3690
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    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAMKK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMKK1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAMKK1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAMKK1

    Additional mRNA sequence: 

    AF425232.1 AF425301.1 AK126617.1 AK128601.1 AL136576.1 BC011401.1 BC031647.1 BC043487.1 

    9 DOTS entries:

    DT.412205  DT.98083256  DT.97792621  DT.100759723  DT.101970571  DT.40254985  DT.100694702  DT.102829061 
    DT.99949406 

    24/76 AceView cDNA sequences (see all 76):

    NM_172206 BM966951 BM127924 AA470785 BQ932168 AA897335 T41157 AF425301 
    AK128601 AW188181 BG060096 AF425232 BX459685 AI685610 AA432185 NM_172207 
    NM_032294 BF002553 AL136576 AI142127 AI206284 AW451519 BM127904 AA324142 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CAMKK1 expression in normal human tissues (normalized intensities)      CAMKK1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATCTGTAAT
    CAMKK1 Expression
    About this image


    CAMKK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 13 entries
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   

    See CAMKK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CAMKK1

    SOURCE GeneReport for Unigene cluster: Hs.8417
        SABiosciences Expression via Pathway-Focused PCR Array including CAMKK1: 
              Prostate Cancer in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for CAMKK1
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAMKK1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMKK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CAMKK1 gene from 10/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Camkk11 , 5 calcium/calmodulin-dependent protein kinase kinase more1, 5 88.84(n)1
    93.47(a)1
      11 (45.12 cM)5
    559841  NM_018883.21  NP_061371.21 
     730190085 
    chicken
    (Gallus gallus)
    Aves CAMKK11 calcium/calmodulin-dependent protein kinase kinase more 70.66(n)
    76.42(a)
      771003  XM_001234324.2  XP_001234325.2 
    lizard
    (Anolis carolinensis)
    Reptilia CAMKK16
    --
    --
    72(a)
    64(a)
    1 ↔ 1
    possible ortholog
    AAWZ02040127(21-5861)
    GL343913.1(137250-145095)
    African clawed frog
    (Xenopus laevis)
    Amphibia CaM-KK2 calcium/calmodulin-dependent protein kinase kinase 74.52(n)    AB083001.1 
    zebrafish
    (Danio rerio)
    Actinopterygii camkk11 calcium/calmodulin-dependent protein kinase kinase more 70.58(n)
    74.18(a)
      541526  NM_001014339.1  NP_001014361.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG176986
    --
    29(a)
    1 → many
    3L(23731060-23742158)
    worm
    (Caenorhabditis elegans)
    Secernentea ckk-11 Protein CKK-1 55.64(n)
    55.73(a)
      182278  NM_001025982.2  NP_001021153.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SAK1(YER129W)4 Upstream serine/threonine kinase for the SNF1 complex; more   --   5(417281-420709) 856866  NP_011055.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GRIK21 geminivirus rep interacting kinase 2 50.06(n)
    42.26(a)
      836176  NM_125448.4  NP_200863.2 
    rice
    (Oryza sativa)
    Liliopsida Os03g07113001 hypothetical protein 50.19(n)
    42.32(a)
      4333884  NM_001057590.1  NP_001051055.1 


    ENSEMBL Gene Tree for CAMKK1 (if available)
    TreeFam Gene Tree for CAMKK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CAMKK1 gene
    CAMKK22  STK112  
    18/21 SIMAP similar genes for CAMKK1 using alignment to 3 protein entries:     KKCC1_HUMAN (see all proteins) (see all similar genes):
    CAMKK2    STK11    MARK4    MAPK13    NUAK1    RPS6KA2
    TRIB1    PRKD1    PRKAA1    RPS6KA3    CDK4    PRKACB
    CHEK2    MYO3A    TSSK3    CCRK    TRIB2    CAMK2D

    CAMKK1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/977 SNPs in CAMKK1 are shown (see all 977)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1142439321,2
    C,F--3763155(+) GACTCT/CTTTCG 2 -- ds50011Minor allele frequency- C:0.04WA 118
    rs1860401001,2
    --3763238(+) TAAGCA/GGGGAT 2 -- ds50010--------
    rs1427580151,2
    --3763253(+) GGTCAC/TTGGGC 2 -- ds50010--------
    rs22408091,2
    C,F,A,H--3763433(-) GTGACG/CGGGCT 2 -- ds50019Minor allele frequency- C:0.38NA WA CSA EA 369
    rs739741411,2
    C,F--3763434(+) GCCCGG/ATCACC 2 -- ds50012Minor allele frequency- A:0.11WA 120
    rs739741421,2
    C,F--3763506(+) TCAGGG/AACTTA 2 -- ds50014Minor allele frequency- A:0.14WA CSA 123
    rs15582941,2
    C,F,A,H--3763574(-) TATACG/ATTCTT 2 -- ds500129Minor allele frequency- A:0.29NS EA NA WA 4856
    rs22408081,2
    C,F--3763609(-) AAAAAA/TGGTTT 2 -- ut31 trp31Minor allele frequency- T:0.03EA 120
    rs2022004421,2
    C--3763680(+) ATTTT-/AAAACA 2 -- ut310--------
    rs1389044831,2
    C--3763769(+) CATCCC/TACCTG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for CAMKK1 (3763609 - 3798185 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/25 variations for CAMKK1 (see all 25):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2662801CNV Deletion23128226
    dgv443e201CNV Deletion23290073
    dgv442e201CNV Deletion23290073
    esv2150356CNV Deletion18987734
    esv998088CNV Deletion20482838
    esv2715535CNV Deletion23290073
    esv2715534CNV Deletion23290073
    nsv820660CNV Deletion20802225
    esv2662233CNV Deletion23128226
    esv992121CNV Deletion20482838


    Human Gene Mutation Database (HGMD): CAMKK1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CAMKK1
    DNA2.0 Custom Variant and Variant Library Synthesis for CAMKK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611411    OMIM disorders: --

    7 diseases for CAMKK1:    About MalaCards
    esophageal adenocarcinoma    lung cancer    esophagitis    adenocarcinoma
    prostate cancer    neuronitis    prostatitis


    CAMKK1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CAMKK1
    Human Genome Epidemiology (HuGE) Navigator: CAMKK1 (4 documents)

    Export disorders for CAMKK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CAMKK1 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with CAMKK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    2. International Lung Cancer Consortium: coordinated ass ociation study of 10 potential lung cancer susceptibility variants. (PubMed id 20106900)1, 4 Truong T....Hung R.J. (2010)
    3. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (2010)
    4. Genome-wide and candidate gene association study of cigarette smoking behaviors. (PubMed id 19247474)1, 4 Caporaso N....Bergen A.W. (2009)
    5. Variants in the GH-IGF axis confer susceptibility to lung cancer. (PubMed id 16741161)1, 4 Rudd M.F....Houlston R.S. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells. (PubMed id 12935886)1, 2 Ishikawa Y....Kobayashi R. (2003)
    8. Studies on the phosphorylation of protein kinase B by Ca(2+)/calmodulin-dependent protein kinases. (PubMed id 10833263)1, 9 Okuno S....Fujisawa H. (2000)
    9. Regulation of Ca(2+)/calmodulin-dependent protein kinase kinase alpha by cAMP-dependent protein kinase: I. Biochemical analysis. (PubMed id 11574070)1, 9 Okuno S....Fujisawa H. (2001)
    10. 14-3-3 proteins sequester a pool of soluble TRIM32 ubi quitin ligase to repress autoubiquitylation and cytoplasmic body formation. (PubMed id 23444366)1 Ichimura T....Hachiya N. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84254 HGNC: 1469 AceView: CAMKK1 Ensembl:ENSG00000004660 euGenes: HUgn84254
    ECgene: CAMKK1 Kegg: 84254 H-InvDB: CAMKK1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CAMKK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CAMKK1 gene:
    Search GeneIP for patents involving CAMKK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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