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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CAMK4 Gene

protein-coding   GIFtS: 69
GCID: GC05P110587

calcium/calmodulin-dependent protein kinase IV
 Explore 23 diseases affiliated with
CAMK4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CAMK4    

Aliases
for CAMK4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Calcium/Calmodulin-Dependent Protein Kinase IV1 2     Calcium/Calmodulin-Dependent Protein Kinase Type IV Catalytic Chain2
CaMK-GR1 2     CAM Kinase IV2
CaM Kinase-GR2 3     CAM Kinase- GR2
CaMK IV2 3     CAMK3
IV2     CAMK-GR3
Brain Ca(2+)-Calmodulin-Dependent Protein Kinase Type IV2     CAMKIV3
Brain Ca++-Calmodulin-Dependent Protein Kinase Type IV2     EC 2.7.11.173
CaMK1     EC 2.7.118
Calcium/Calmodulin-Dependent Protein Kinase Type IV2     

External Ids:    HGNC: 14641   Entrez Gene: 8142   Ensembl: ENSG000001524957   OMIM: 1140805   UniProtKB: Q165663   

Export aliases for CAMK4 gene to outside databases

Previous GC identifers: GC05P110183 GC05P111005 GC05P110590 GC05P110636 GC05P105739


Summaries
for CAMK4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CAMK4:
The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent
protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue
distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KCC4_HUMAN, Q16566
Function: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling
cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1,
MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the
thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4
memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4
(through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and
dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2.
Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory
consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1
and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in
vitro CREBBP, PRM2, MEF2A and STMN1/OP18

Gene Wiki entry for CAMK4


Genomic Views
for CAMK4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CAMK4 gene promoter:
         AhR   AML1a   Pbx1a   Nkx2-5   CREB   FAC1   Pax-3   deltaCREB   HFH-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CAMK4 promoter sequence
   Search SABiosciences Chromatin IP Primers for CAMK4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAMK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q21.3   Ensembl cytogenetic band:  5q22.1   HGNC cytogenetic band: 5q22.1

CAMK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAMK4 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P110587:  view genomic region     (about GC identifiers)

Start:
 110,559,351 bp from pter      End:
 110,830,584 bp from pter
Size:
 271,234 bases      Orientation:
 plus strand

Proteins
for CAMK4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KCC4_HUMAN, Q16566 (See protein sequence)
Recommended Name: Calcium/calmodulin-dependent protein kinase type IV  
Size: 473 amino acids; 51926 Da
Subunit: Monomer (By similarity). Interacts with protein phosphatase 2A (PPP2CA/PPP2CB); the interaction is mutually
exclusive with binding to Ca(2+)/calmodulin
Subcellular location: Cytoplasm. Nucleus. Note=Localized in hippocampal neuron nuclei. In spermatids, associated with
chromatin and nuclear matrix (By similarity)
Developmental stage: Expressed during differentiation of monocyte-derived dendritic cells (at protein level)
Sequence caution: Sequence=AAH16695.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for CAMK4:
2W4O (3D)    
Secondary accessions: D3DSZ7

Explore the universe of human proteins at neXtProt for CAMK4: NX_Q16566

Post-translational modifications:

  • Phosphorylated by CaMKK1 and CaMKK2 on Thr-200. Dephosphorylated by protein phosphatase 2A. Autophosphorylated on
    • Ser-12 and Ser-131
  • Glycosylation at Ser-189 modulates the phosphorylation of CaMK4 at Thr-200 and negatively regulates its activity toward
    • CREB1 in basal conditions and during early inomycin stimulation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q16566

    • 4/9 DME Specific Peptides for CAMK4 (Q16566) (see all 9)
     FNARRKL  HPNIIKL  AKDLVRK  GGELFDR 

    CAMK4 Protein expression data from MOPED and PaxDb:    About this image 
    CAMK4 Protein Expression
    REFSEQ proteins: NP_001735.1  
    ENSEMBL proteins: 
     ENSP00000426940   ENSP00000422634   ENSP00000282356   ENSP00000424912   ENSP00000423761  
     ENSP00000421606  
    Reactome Protein details: Q16566
    Human Recombinant Protein Products for CAMK4: 
    EMD Millipore Purified and/or Recombinant CAMK4 Protein
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    Enzo Life Sciences proteins for CAMK4
    OriGene Purified Protein: CAMK4
    OriGene Protein Over-expression Lysate: CAMK4
    OriGene Custom Protein Services for CAMK4 
    GenScript Custom Purified and Recombinant Proteins Services for CAMK4
    Novus Biologicals CAMK4 Proteins
    Novus Biologicals CAMK4 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CAMK4
    Uscn Proteins for CAMK4

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    CAMK4 for ontologies           About GeneDecksing



    CAMK4 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CAMK4
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    Cell Signaling Technology (CST) Antibodies for CAMK4 
    OriGene Antibodies (see all 2): CAMK4
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    GenScript Superior Antibodies for CAMK4
    Novus Biologicals CAMK4 Antibodies
    Abcam antibodies for CAMK4 
    Uscn Antibodies for CAMK4
    ThermoFisher Antibody for CAMK4

    Assay Products for CAMK4: 
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    Browse OriGene Fluorogenic Cell Assay Kits
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    GenScript Custom Assay Services for CAMK4
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CAMK4

    Protein Domains /
    Families
    for CAMK4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CAMK4 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q16566

    ProtoNet protein and cluster: Q16566

    UniProtKB/Swiss-Prot: KCC4_HUMAN, Q16566
    Domain: The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded
    state with the catalytic domain as a pseudosubstrate
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for CAMK4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCC4_HUMAN, Q16566
    Function: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling
    cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1,
    MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the
    thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4
    memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4
    (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and
    dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2.
    Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory
    consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1
    and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in
    vitro CREBBP, PRM2, MEF2A and STMN1/OP18
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves
    intrasteric autoinhibition and allows phosphorylation of Thr-200 within the activation loop by CaMKK1 or CaMKK2.
    Phosphorylation of Thr-200 results in a 10-20-fold increase in total activity to generate
    Ca(2+)/calmodulin-independent activity. Autophosphorylation of the N-terminus Ser-12 and Ser-13 is required for full
    activation. Inactivated by protein phosphatase 2A (PPP2CA/PPP2CB) which dephosphorylates Thr-200, thereby terminating
    autonomous activity and helping to maintain the enzyme in its autoinhibited state

         Genatlas biochemistry entry for CAMK4:
    protein kinase,type IV,calcium/calmodulin dependent,brain

         Enzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.171

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004683calmodulin-dependent protein kinase activity IEA--
    GO:0005515protein binding ----
    GO:0005516calmodulin binding IEA--
    GO:0005524ATP binding IEA--
         
    CAMK4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CAMK4:
     Decreased substrate adherent c 

         13 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Camk4):
     behavior/neurological  cellular  endocrine/exocrine gland  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  integument  mortality/aging  nervous system 
     normal  reproductive system  skeleton 

    CAMK4 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for CAMK4: Camk4tm1Tsmi Camk4tm1Arm Camk4tm2Arm Camk4tm1Tch
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CAMK4 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: CAMK4
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAMK4
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate CAMK4 (see all 11):
    hsa-miR-30c hsa-miR-586 hsa-miR-30d hsa-miR-885-5p hsa-miR-507 hsa-miR-33a hsa-miR-30a hsa-miR-4274
    SwitchGear 3'UTR luciferase reporter plasmid: CAMK4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAMK4 (see all 7)
    OriGene shRNA RFP: CAMK4
    OriGene siRNA: CAMK4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAMK4
    Sirion Biotech Custom design and validation of potent shRNA sequences against CAMK4 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CAMK4
    Sirion Biotech Customized adenovirus for overexpression of CAMK4 
    Sirion Biotech Customized adenovirus for potent knockdown of CAMK4

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAMK4 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAMK4 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CAMK4 (NM_001744)
    Sino Biological Human cDNA Clone for CAMK4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAMK4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMK4 

    Cell Line
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    Search LifeMap BioReagents cell lines for CAMK4
    Sirion Biotech Customized stable knockdown cell line services for CAMK4 
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    Sirion Biotech Customized stable overexpressing cell line services for CAMK4
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMK4


    Pathways & Interactions
    for CAMK4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/41 super-pathways (see all 41) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by FGFR
    8/12 pathways (see all 12)
    		Signaling by FGFR1.00
    		DAP12 signaling0.83
    		Downstream signaling of activated FGFR0.92
    		Signaling by EGFR in Cancer0.83
    		Signaling by FGFR in disease0.91
    		DAP12 interactions0.76
    		Signaling by ERBB20.89
    		Signaling by PDGF0.72
    2DAG and IP3 signaling
    		DAG and IP3 signaling1.00
    		CaM pathway0.84
    		PLC-gamma1 signalling0.94
    		Calmodulin induced events0.84
    		EGFR interacts with phospholipase C-gamma0.94
    		Ca-dependent events0.79
    		PLCG1 events in ERBB2 signaling0.91
    		Phospholipase C-mediated cascade0.57
    3CaMK IV-mediated phosphorylation of CREB
    		CaMK IV-mediated phosphorylation of CREB1.00
    		Activation of CaMK IV0.67
    		CREB phosphorylation through the activation of CaMKK0.75
    4Opioid Signalling
    		Opioid Signalling1.00
    		PLC beta mediated events0.54
    		G-protein mediated events0.55
    5Transmission across Chemical Synapses
    		Transmission across Chemical Synapses1.00
    		Neuronal System0.67
    		Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/6 EMD Millipore Pathways for CAMK4 (see all 6)
        Signal transduction Calcium signaling
    Immune response Function of MEF2 in T lymphocytes
    Signal transduction IP3 signaling
    Signal transduction cAMP signaling
    Transcription CREB pathway

    5/16 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CAMK4 (see all 16)
        PKA Signaling
    IGF1R Signaling
    Intracellular Calcium Signaling
    CRHR Pathway
    Thrombin Signaling

    2 Cell Signaling Technology (CST) Pathways for CAMK4
        Ca, cAMP and Lipid Signaling
    Neuroscience

    5/6 GeneGo (Thomson Reuters) Pathways for CAMK4 (see all 6)
        Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Signal transduction cAMP signaling
    Transcription CREB pathway
    Immune response Function of MEF2 in T lymphocytes
    Signal transduction Calcium signaling

    5/8 BioSystems Pathways for CAMK4 (see all 8) 
        Mitochondrial Gene Expression
    Calcium Regulation in the Cardiac Cell
    Hypothetical Network for Drug Addiction
    Energy Metabolism
    Signaling events mediated by HDAC Class II

    5/36        Reactome Pathways for CAMK4 (see all 36)
        Signaling by EGFR in Cancer
    Post NMDA receptor activation events
    Downstream signal transduction
    Activation of CaMK IV
    Signal Transduction


    5         Kegg Pathways  (Kegg details for CAMK4):
        Calcium signaling pathway
    Osteoclast differentiation
    Long-term potentiation
    Neurotrophin signaling pathway
    Cholinergic synapse


    CAMK4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CAMK4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/25 Interacting proteins for CAMK4 (Q165663 ENSP000002823564) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC4P565243, ENSP000002646064I2D: score=3 STRING: ENSP00000264606
    CAMKK2Q96RR43, ENSP000003127414I2D: score=2 STRING: ENSP00000312741
    GAPDHP044063, ENSP000002292394I2D: score=2 STRING: ENSP00000229239
    NOS1P294753, ENSP000003207584I2D: score=1 STRING: ENSP00000320758
    CAMKK1Q8N5S93, ENSP000001581664I2D: score=1 STRING: ENSP00000158166
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002372NOT myeloid dendritic cell cytokine production IMP17909078
    GO:0006468protein phosphorylation TAS8089075
    GO:0006913nucleocytoplasmic transport IEA--
    GO:0006954inflammatory response IEA--
    GO:0007165signal transduction TAS--

    CAMK4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CAMK4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CAMK4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CAMK4

    3 HMDB Compounds for CAMK4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--

    2 DrugBank Compounds for CAMK4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one-- --target--10592235
    5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE-- --target--10592235

    10/13 Novoseek chemical compound relationships for CAMK4 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    syntide-2 86.4 1 15262326 (1)
    calcium 53.5 41 1645731 (3), 10191497 (2), 20171262 (2), 19711354 (2) (see all 27)
    threonine 45.8 5 19538941 (1), 10932193 (1), 15143065 (1), 15262326 (1)
    serine 42.6 7 1645731 (1), 19538941 (1), 10932193 (1), 1901412 (1) (see all 6)
    cyclic amp 41.8 2 17428448 (1), 12234621 (1)
    ionomycin 33.2 1 7925472 (1)
    atp 25.8 1 8194751 (1)
    retinoid 19.4 1 11559707 (1)
    nmda 12.7 2 19633294 (1)
    magnesium 0 1 8586621 (1)

    Search CenterWatch for drugs/clinical trials and news about CAMK4 / KCC4 

    Transcripts
    for CAMK4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CAMK4 gene: 
    NM_001744.4  

    Unigene Cluster for CAMK4:

    Calcium/calmodulin-dependent protein kinase IV
    Hs.591269  [show with all ESTs]
    Unigene Representative Sequence: NM_001744
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508074 ENST00000512453 ENST00000282356(uc003kpf.3 uc010jbv.3)
    ENST00000515231 ENST00000504544 ENST00000509408 ENST00000514007 ENST00000504090
    ENST00000502916 ENST00000505763 ENST00000509645(uc003kpg.3) ENST00000510858
    ENST00000512890

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAMK4
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate CAMK4 (see all 11):
    hsa-miR-30c hsa-miR-586 hsa-miR-30d hsa-miR-885-5p hsa-miR-507 hsa-miR-33a hsa-miR-30a hsa-miR-4274
    SwitchGear 3'UTR luciferase reporter plasmid: CAMK4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAMK4 (see all 7)
    OriGene shRNA RFP: CAMK4
    OriGene siRNA: CAMK4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAMK4
    Sirion Biotech Custom design and validation of potent shRNA sequences against CAMK4 
    Clone
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    Additional cDNA sequence: 

    AK311662.1 AK312840.1 BC016695.1 BC025687.1 D30742.1 L17000.1 L24959.1 

    8 DOTS entries:

    DT.408507  DT.311969  DT.120813754  DT.120813794  DT.95161510  DT.120813801  DT.97771009  DT.99991905 

    24/39 AceView cDNA sequences (see all 39):

    BP379092 D30742 CR622299 AL134969 BC025687 NM_001744 BM986829 AL119808 
    BX376712 AI627334 AA455227 L24959 CR615443 AA361421 CD558096 CB141413 
    L17000 BU165729 BI548325 CD557572 BX374853 BI561151 BG719489 BP371266 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CAMK4    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c
    SP1:              -     -                           
    SP2:                                                
    SP3:                                                


    ECgene alternative splicing isoforms for CAMK4

    Expression
    for CAMK4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CAMK4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGCCATATG
    CAMK4 Expression
    About this image

    CAMK4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesElongated SpermatidGerm Cells, Male Gametocytes
    TestisSeminiferous TubulesSpermatidGerm Cells, Male Gametocytes
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Cartilage-like cells (Differentiation of s...)Cartilage

    See CAMK4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CAMK4

    SOURCE GeneReport for Unigene cluster: Hs.591269

    UniProtKB/Swiss-Prot: KCC4_HUMAN, Q16566
    Tissue specificity: Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue

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    In Situ
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    Orthologs
    for CAMK4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CAMK4 gene from 6/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CAMK41 calcium/calmodulin-dependent protein kinase IV 76.71(n)
    80(a)    		   723973  NM_001034813.1  NP_001029985.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CAMK46
    		 --
    		 87(a)
    		 1 ↔ 1
    		 GL343193.1(6300581-6421509)
    African clawed frog
    (Xenopus laevis)    		 Amphibia camk4-A2 calcium/calmodulin-dependent protein kinase IV 81.16(n)    AF316822.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii camk41 calcium/calmodulin-dependent protein kinase IV 72.71(n)
    81.04(a)    		   550270  NM_001017607.1  NP_001017607.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons CPK331 calcium-dependent protein kinase 33 50.74(n)
    42.27(a)    		   841492  NM_103952.3  NP_175485.1 
    rice
    (Oryza sativa)    		 Liliopsida Os07g05151001 hypothetical protein 50.78(n)
    42.33(a)    		   4343373  NM_001066310.1  NP_001059775.1 


    ENSEMBL Gene Tree for CAMK4 (if available)
    TreeFam Gene Tree for CAMK4 (if available) 

    Paralogs
    for CAMK4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CAMK4 gene
    PNCK2  CAMK1G2  PSKH22  DCX2  DCLK22  CAMK2A2  CAMK1D2  DCLK12  
    PSKH12  CAMK2D2  DCLK32  CAMKV2  CAMK2G2  CAMK2B2  CAMK12  
    18/42 SIMAP similar genes for CAMK4 using alignment to 4 protein entries:     KCC4_HUMAN (see all proteins) (see all similar genes):
    PNCK    CAMK1    CAMK1D    PSKH1    RPS6KA2    CAMK1G
    DCLK3    MAPKAPK5    RPS6KA4    MGC45428    MYLK4    PSKH2
    RPS6KA3    RPS6KA1    CAMKV    DCLK2    TTN    CAMK2D

    CAMK4 for paralogs           About GeneDecksing



    Genomic Variants
    for CAMK4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/80 NCBI SNPs in CAMK4 are shown (see all 80)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs58704331,2
    		C--110558893(+) TCAGGA/-AAAAA 1 -- us2k1 trp31Minor allele frequency- -:0.00CSA 2
    rs100578211,2
    		C--110601930(+) CACACG/ACACAC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs2009081411,2
    		--110666440(+) TAACT-/GCACTGT 1 -- int10--------
    rs1424821991,2
    		--110682214(+) TATCT-/CCATCC
                ATCTA     		1 -- int10--------
    rs670379091,2
    		C--110688065(-) TTTGCA/-CATTT 1 -- int11Minor allele frequency- -:0.00NA 2
    rs340904821,2
    		C--110689947(+) ACTCA-/AGAGAG 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1436151571,2
    		C--110690311(+) CTGAG-/GCA   
      GGAGAA    TCACT     		1 -- int10--------
    rs709736041,2
    		C--110691211(-) TAATAAAAT/-  
                AAATA     		1 -- int11Minor allele frequency- -:0.00NA 2
    rs572251601,2
    		C--110693258(+) AACAGAG/-GACGA 1 -- int11Minor allele frequency- -:0.00NA 2
    rs104636171,2
    		A,H--110694987(+) ttgtgG/Cttttg 1 -- int14Minor allele frequency- C:0.00NS EA 386

    HapMap Linkage Disequilibrium report for CAMK4 (110559351 - 110809351 bp, first 250kb of CAMK4)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for CAMK4
         2 CNVs: 99257 64276
         5 Indels: 27765 46748 62416 12734 42166
    Human Gene Mutation Database (HGMD): CAMK4

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    Disorders / Diseases
    for CAMK4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CAMK4 for disorders           About GeneDecksing

    OMIM gene information: 114080    OMIM disorders: --

    20/23 diseases for CAMK4 (see all 23):    About MalaCards
    allan-herndon-dudley syndrome    systemic lupus erythematosus    lupus erythematosus    alcohol dependence
    cerebral hypoxia    epithelial ovarian cancer    blastoma    neuronitis
    fibromatosis    neurodegenerative disease    ovarian cancer    azoospermia
    endometrial carcinoma    cerebritis    hypoxia    hematopoiesis
    alcoholism    gingivitis    cholesterol    neuroblastoma

    1 Novoseek disease relationship for CAMK4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cerebral hypoxia 51.2 1 15262326 (1)

    Human Genome Epidemiology (HuGE) Navigator: CAMK4 (5 documents)

    Export disorders for CAMK4 gene to outside databases

    Publications
    for CAMK4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CAMK4 gene, integrated from 9 sources (see all 138):
    (articles sorted by number of sources associating them with CAMK4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1. (PubMed id 8107230)1, 2, 9 Mosialos G....Chatila T.A. (1994)
    2. Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex. (PubMed id 15143065)1, 2, 9 Anderson K.A.... Means A.R. (2004)
    3. The cDNA sequence and characterization of the Ca2+/calmodulin- dependent protein kinase-Gr from human brain and thymus. (PubMed id 8194751)1, 2, 9 Bland M.M.... Ohmstede C.A. (1994)
    4. cDNA cloning and expression of human calmodulin-dependent protein kinase IV. (PubMed id 8089075)1, 2, 9 Kitani T.... Fujisawa H. (1994)
    5. Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade. (PubMed id 8855261)1, 2, 9 Enslen H....Soderling T.R. (1996)
    6. Regulation of calcium/calmodulin-dependent kinase IV by O-GlcNAc modification. (PubMed id 19506079)1, 2 Dias W.B....Hart G.W. (2009)
    7. Calcium/calmodulin-dependent kinase IV in immune and inflammatory responses: novel routes for an ancient traveller. (PubMed id 18930438)1, 2 Racioppi L. and Means A.R. (2008)
    8. Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells. (PubMed id 17909078)1, 2 Illario M....Racioppi L. (2008)
    9. Upregulation of calcium/calmodulin-dependent protein kinase IV improves memory formation and rescues memory loss with aging. (PubMed id 18829949)1, 2 Fukushima H....Kida S. (2008)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for CAMK4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CAMK4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 814 HGNC: 1464 AceView: CAMK4 Ensembl:ENSG00000152495 euGenes: HUgn814
    ECgene: CAMK4 Kegg: 814 H-InvDB: CAMK4

    Other Databases showing CAMK4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CAMK4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CAMK4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CAMK4 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CAMK4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CAMK4 gene:
    Search GeneIP for patents involving CAMK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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