Aliases for CAMK4 Gene
Aliases for CAMK4 Gene
External Ids for CAMK4 Gene
- HGNC: 1464
- Entrez Gene: 814
- Ensembl: ENSG00000152495
- OMIM: 114080
- UniProtKB: Q16566
Previous GeneCards Identifiers for CAMK4 Gene
- GC05P110183
- GC05P111005
- GC05P110590
- GC05P110636
- GC05P110587
- GC05P105739
Summaries for CAMK4 Gene
-
The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008]
GeneCards Summary for CAMK4 Gene
CAMK4 (Calcium/Calmodulin Dependent Protein Kinase IV) is a Protein Coding gene. Diseases associated with CAMK4 include Cerebral Hypoxia and Gingival Fibromatosis. Among its related pathways are MAPK-Erk Pathway and Development ERBB-family signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CAMK1G.
UniProtKB/Swiss-Prot for CAMK4 Gene
-
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on Ser-133 in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMK4 Gene
Genomics for CAMK4 Gene
Regulatory Elements for CAMK4 Gene
Enhancers for CAMK4 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH05G111223 | 1.9 | FANTOM5 Ensembl ENCODE dbSUPER | 20.8 | +8.0 | 8001 | 16.7 | HDGF PKNOX1 WRNIP1 SIN3A ZNF121 GLIS2 CBX5 ZNF207 FOS KLF7 | CAMK4 ENSG00000249318 TSLP WDR36 GC05M111236 |
| GH05G111251 | 1.5 | FANTOM5 ENCODE dbSUPER | 8.2 | +30.2 | 30228 | 3.9 | HDGF PKNOX1 FEZF1 YBX1 CBX5 ZNF143 JUNB TSHZ1 TBX21 SMARCA4 | TSLP CAMK4 WDR36 GC05P111246 ENSG00000249318 |
| GH05G111143 | 0.9 | Ensembl ENCODE | 4.1 | -79.3 | -79302 | 1.1 | CTCF JUNB EBF1 ZFHX2 JUND CBX5 IKZF1 EED IKZF2 EGR2 | TSLP CAMK4 GC05M111139 GC05P111128 |
| GH05G111248 | 0.6 | dbSUPER | 5.5 | +24.6 | 24645 | 1.8 | OSR2 PRDM6 JUND SMARCA4 GFI1B PRDM1 | ENSG00000249318 TSLP CAMK4 GC05P111246 |
| GH05G111247 | 0.6 | dbSUPER | 5.5 | +24.6 | 24645 | 1.8 | OSR2 PRDM6 JUND SMARCA4 GFI1B PRDM1 | ENSG00000249318 TSLP CAMK4 GC05P111246 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CAMK4 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for CAMK4 Gene
- Chromosome:
- 5
- Start:
- 111,223,653 bp from pter
- End:
- 111,494,886 bp from pter
- Size:
- 271,234 bases
- Orientation:
- Plus strand
Genomic View for CAMK4 Gene
Genes around CAMK4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q22.1 by Ensembl
- 5q22.1 by Entrez Gene
- 5q22.1 by HGNC
CAMK4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CAMK4 Gene
Proteins for CAMK4 Gene
-
Protein details for CAMK4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q16566-KCC4_HUMAN
- Recommended name:
- Calcium/calmodulin-dependent protein kinase type IV
- Protein Accession:
- Q16566
- D3DSZ7
Protein attributes for CAMK4 Gene
- Size:
- 473 amino acids
- Molecular mass:
- 51926 Da
- Quaternary structure:
-
- Monomer (By similarity). Interacts with protein phosphatase 2A (PPP2CA/PPP2CB); the interaction is mutually exclusive with binding to Ca(2+)/calmodulin.
- SequenceCaution:
-
- Sequence=AAH16695.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for CAMK4 Gene
Selected DME Specific Peptides for CAMK4 Gene
- Q16566:
-
- AKDLVRK
- HPNIIKL
- VTGGELF
- GGELFDR
- LKPENLL
- RDLKPEN
- FNARRKL
- VHRDLKP
- IVHRDLK
Post-translational modifications for CAMK4 Gene
- Glycosylation at Ser-189 modulates the phosphorylation of CaMK4 at Thr-200 and negatively regulates its activity toward CREB1 in basal conditions and during early inomycin stimulation.
- Phosphorylated by CaMKK1 and CaMKK2 on Thr-200. Dephosphorylated by protein phosphatase 2A. Autophosphorylated on Ser-12 and Ser-13.
- Ubiquitination at posLast=190190 and posLast=303303
- Glycosylation at posLast=5757, Ser58, Ser137, posLast=189189, Ser344, Ser345, and Ser356
- Modification sites at PhosphoSitePlus
Other Protein References for CAMK4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CAMK4
- Cell Signaling Technology (CST) Antibodies for CAMK4 (CAMK4)
- Novus Biologicals Antibodies for CAMK4
- Invitrogen Antibodies for CAMK4
- antibodies-online Antibodies for CAMK4: See all 154
- GeneTex CAMK4 antibody for CAMK4
-
Santa Cruz Biotechnology (SCBT) Antibodies for CAMK4
Protein Products
- EMD Millipore Purified and/or Recombinant CAMK4 Protein
-
OriGene Purified Proteins for CAMK4
- Search Origene for MassSpec and Protein Over-expression Lysates for CAMK4
- Origene Custom Protein Services for CAMK4
- Sino Biological Cell Lysates for CAMK4
- Sino Biological Recombinant Proteins for CAMK4
- ProSpec Recombinant Proteins for CAMK4
- antibodies-online Proteins for CAMK4: See all 16
- Search antibodies-online for peptides
- GeneTex Proteins for CAMK4
Assay Products
- antibodies-online Kits for CAMK4: See all 9
Domains & Families for CAMK4 Gene
Gene Families for CAMK4 Gene
Protein Domains for CAMK4 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CAMK4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q16566UniProtKB/Swiss-Prot:
KCC4_HUMAN :- The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.
- Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
- Domain:
-
- The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.
- Family:
-
- Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Function for CAMK4 Gene
Molecular function for CAMK4 Gene
- GENATLAS Biochemistry:
- protein kinase,type IV,calcium/calmodulin dependent,brain
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows phosphorylation of Thr-200 within the activation loop by CaMKK1 or CaMKK2. Phosphorylation of Thr-200 results in a 10-20-fold increase in total activity to generate Ca(2+)/calmodulin-independent activity. Autophosphorylation of the N-terminus Ser-12 and Ser-13 is required for full activation. Inactivated by protein phosphatase 2A (PPP2CA/PPP2CB) which dephosphorylates Thr-200, thereby terminating autonomous activity and helping to maintain the enzyme in its autoinhibited state.
- UniProtKB/Swiss-Prot Function:
- Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on Ser-133 in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.
Enzyme Numbers (IUBMB) for CAMK4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IEA | -- |
| GO:0004683 | calmodulin-dependent protein kinase activity | IDA | 8107230 |
| GO:0005516 | calmodulin binding | IBA,IEA | -- |
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for CAMK4 Gene
- MGI mutant phenotypes for CAMK4:
-
inferred from 5 alleles
- mortality/aging
- cellular phenotype
- behavior/neurological phenotype
- normal phenotype
- growth/size/body region phenotype
- immune system phenotype
- nervous system phenotype
- homeostasis/metabolism phenotype
- reproductive system phenotype
- endocrine/exocrine gland phenotype
- integument phenotype
- skeleton phenotype
- hematopoietic system phenotype
- GenomeRNAi human phenotypes for CAMK4:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased viability ratio
- Increased transferrin (TF) endocytosis
- Transferrin accumulation in the perinuclear area
- Increased shRNA abundance (Z-score > 2)
- Decreased viability
- Decreased vesicular stomatitis virus (VSV) infection
- Decreased shRNA abundance (Z-score < -2)
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased cell viability after pRB stimulation
- Decreased substrate adherent cell growth
- Increased simian virus 40 (SV40) infection
- Decreased Cdk9 T-loop phosphorylation
Animal Models for CAMK4 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CAMK4
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CAMK4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CAMK4 gene
- Search ViGene Biosciences for CAMK4
CRISPR Products
-
OriGene CRISPR knockouts for CAMK4
-
Santa Cruz Biotechnology (SCBT) CRISPR for CAMK4
- GenScript: Design CRISPR guide RNA sequences for CAMK4
miRNA for CAMK4 Gene
- miRTarBase miRNAs that target CAMK4
-
- hsa-mir-215-5p (MIRT024679)
- hsa-mir-192-5p (MIRT026869)
- hsa-mir-26b-5p (MIRT030257)
- hsa-mir-185-5p (MIRT437481)
- hsa-mir-6792-3p (MIRT460330)
- hsa-mir-4691-5p (MIRT460331)
- hsa-mir-6509-3p (MIRT460332)
- hsa-mir-196a-3p (MIRT460333)
- hsa-mir-3128 (MIRT460334)
- hsa-mir-4746-5p (MIRT460335)
- hsa-mir-1273g-3p (MIRT460336)
- hsa-mir-181a-2-3p (MIRT460337)
- hsa-mir-6807-5p (MIRT496932)
- hsa-mir-922 (MIRT496933)
- hsa-mir-1245b-3p (MIRT496934)
- hsa-mir-574-5p (MIRT628363)
- hsa-mir-4455 (MIRT628364)
- hsa-mir-30e-3p (MIRT628365)
- hsa-mir-30d-3p (MIRT628366)
- hsa-mir-30a-3p (MIRT628367)
- hsa-mir-6867-5p (MIRT628368)
- hsa-mir-622 (MIRT628369)
- hsa-mir-629-3p (MIRT719212)
- hsa-mir-6867-3p (MIRT719213)
- hsa-mir-4713-5p (MIRT719214)
- hsa-mir-3156-3p (MIRT719215)
- hsa-mir-1255b-5p (MIRT719216)
- hsa-mir-1255a (MIRT719217)
- hsa-mir-3605-5p (MIRT719218)
- hsa-mir-6770-5p (MIRT719219)
- hsa-mir-1253 (MIRT719220)
- hsa-mir-2116-3p (MIRT719221)
- hsa-mir-532-3p (MIRT719222)
- hsa-mir-150-5p (MIRT719223)
- hsa-mir-4301 (MIRT719224)
- hsa-mir-329-5p (MIRT719225)
- hsa-mir-5197-3p (MIRT719226)
miRNA Products
- Search ViGene Biosciences for CAMK4
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CAMK4
- Browse OriGene Inhibitory RNA Products For CAMK4
-
ViGene Biosciences ready-to-package AAV shRNAs for CAMK4 gene
Clone Products
-
OriGene ORF clones in human for CAMK4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CAMK4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CAMK4
- VectorBuilder custom plasmid, inducible vectors for CAMK4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CAMK4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CAMK4
-
ViGene Biosciences adenoviral particle packaged cDNA for CAMK4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CAMK4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CAMK4 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAMK4 Gene
Localization for CAMK4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CAMK4 Gene
- Cytoplasm. Nucleus. Note=Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity). {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| mitochondrion | 2 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001650 | fibrillar center | IDA | -- |
| GO:0005634 | nucleus | IEA,IBA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IBA,IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for CAMK4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | DAG and IP3 signaling |
.93
|
|
| 2 | RET signaling |
.92
|
|
| 3 | Post NMDA receptor activation events | ||
| 4 | Activation of cAMP-Dependent PKA |
.77
|
.56
|
| 5 | CREB Pathway |
.68
.68
|
|
Pathways by source for CAMK4 Gene
4 Sino Biological pathways for CAMK4 Gene
2 Cell Signaling Technology pathways for CAMK4 Gene
8 BioSystems pathways for CAMK4 Gene
28 Reactome pathways for CAMK4 Gene
12 KEGG pathways for CAMK4 Gene
6 GeneGo (Thomson Reuters) pathways for CAMK4 Gene
16 Qiagen pathways for CAMK4 Gene
Interacting Proteins for CAMK4 Gene
SIGNOR curated interactions for CAMK4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002250 | adaptive immune response | IEA | -- |
| GO:0002372 | NOT myeloid dendritic cell cytokine production | IMP | 17909078 |
| GO:0002376 | immune system process | IEA | -- |
| GO:0006468 | protein phosphorylation | TAS,IEA | 8089075 |
| GO:0006954 | inflammatory response | IEA | -- |
Drugs & Compounds for CAMK4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Adenosine triphosphate | Approved | Nutra | 0 | |||
| 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one | Experimental | Pharma | Target | 0 | ||
| 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE | Experimental | Pharma | Target | 0 | ||
| calcium | Nutra | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
Drug Products
- Enzo Life Sciences drugs & compounds for CAMK4
Transcripts for CAMK4 Gene
mRNA/cDNA for CAMK4 Gene
- (5) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (39) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CAMK4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CAMK4
-
Santa Cruz Biotechnology (SCBT) CRISPR for CAMK4
- GenScript: Design CRISPR guide RNA sequences for CAMK4
miRNA Products
- Search ViGene Biosciences for CAMK4
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CAMK4
- Browse OriGene Inhibitory RNA Products For CAMK4
-
ViGene Biosciences ready-to-package AAV shRNAs for CAMK4 gene
Clone Products
-
OriGene ORF clones in human for CAMK4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CAMK4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CAMK4
- VectorBuilder custom plasmid, inducible vectors for CAMK4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CAMK4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||
| SP2: | |||||||||||||||
| SP3: |
Expression for CAMK4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- Elongated Spermatid Seminiferous Tubules
- Spermatid Seminiferous Tubules
-
Gonad
- Elongated Spermatid Seminiferous Tubules
- Spermatid Seminiferous Tubules
-
Blood (Hematopoietic System)
- Small Pre B-Cells Hematopoietic Bone Marrow
-
Lung (Respiratory System)
- Basal Cells Trachea
-
Epithelial Cells
- Basal Cells Trachea
-
Hair (Integumentary System)
- Bulge Stem Cells Bulge
-
Eye (Sensory Organs)
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Neurons
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Thymus (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for CAMK4 Gene
This gene is overexpressed in Brain - Cerebellar Hemisphere (x12.4), Brain - Cerebellum (x11.3), Brain - Nucleus accumbens (basal ganglia) (x5.0), and Brain - Putamen (basal ganglia) (x4.1).
This gene is overexpressed in Peripheral blood mononuclear cells (34.8), Lymph node (14.7), and Frontal cortex (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CAMK4 Gene
NURSA nuclear receptor signaling pathways regulating expression of CAMK4 Gene:
CAMK4SOURCE GeneReport for Unigene cluster for CAMK4 Gene:
Hs.591269mRNA Expression by UniProt/SwissProt for CAMK4 Gene:
Q16566-KCC4_HUMAN
Tissue specificity:
Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue.
Evidence on tissue expression from TISSUES for CAMK4 Gene
- Nervous system(4.7)
- Blood(4.3)
- Liver(4.1)
- Lung(4.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for CAMK4
-
OriGene qPCR primer pairs for CAMK4
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAMK4 Gene
Orthologs for CAMK4 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CAMK4 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CAMK4 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CAMK4 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Camk4 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Camk4 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CAMK4 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CAMK4 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CAMK4 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CAMK4 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | camk4 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | camk4-A 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | camk4 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CaMKI 35 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | cmk-1 35 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CMK1 35 |
|
ManyToMany | |
| CMK2 35 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.9956 34 |
|
- Species where no ortholog for CAMK4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CAMK4 Gene
Paralogs for CAMK4 Gene
(42) SIMAP similar genes for CAMK4 Gene using alignment to 4 proteins:
Variants for CAMK4 Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_040604 | A lung adenocarcinoma sample | ||||
| VAR_040607 | A lung large cell carcinoma sample | ||||
| rs1000016744 | -- | 111,325,312(+) | TACTG(C/T)AATAA | intron-variant | |
| rs1000031602 | -- | 111,478,621(+) | TTTCA(A/G)TTTTA | intron-variant | |
| rs1000050513 | -- | 111,244,081(+) | CACTT(G/T)TGTCT | intron-variant |
Residual Variation Intolerance Score:
28.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.89;
48.62% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CAMK4 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMK4 Gene
Disorders for CAMK4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cerebral hypoxia |
|
|
| gingival fibromatosis |
|
|
Search CAMK4 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for CAMK4
No data available for UniProtKB/Swiss-Prot and Genatlas for CAMK4 Gene
Publications for CAMK4 Gene
- Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex. (PMID: 15143065) Anderson K.A. … Means A.R. (J. Biol. Chem. 2004) 3 4 22 64
- Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade. (PMID: 8855261) Enslen H. … Soderling T.R. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 4 22 64
- cDNA cloning and expression of human calmodulin-dependent protein kinase IV. (PMID: 8089075) Kitani T. … Fujisawa H. (J. Biochem. 1994) 3 4 22 64
- A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1. (PMID: 8107230) Mosialos G. … Chatila T.A. (J. Virol. 1994) 3 4 22 64
- The cDNA sequence and characterization of the Ca2+/calmodulin- dependent protein kinase-Gr from human brain and thymus. (PMID: 8194751) Bland M.M. … Ohmstede C.A. (Gene 1994) 3 4 22 64
Products for CAMK4 Gene
- Browse Small Molecules at EMD Millipore
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CAMK4
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- Custom Antibody ServicesOriGene Antibodies for CAMK4
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- Santa Cruz Biotechnology (SCBT) Antibodies for CAMK4
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CAMK4 Gene
- (1) GeneCards
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- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
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