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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CAMK4 Gene

protein-coding   GIFtS: 72
GCID: GC05P110587

Calcium/Calmodulin-Dependent Protein Kinase IV

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Calcium/Calmodulin-Dependent Protein Kinase IV1 2     Brain Ca(2+)-Calmodulin-Dependent Protein Kinase Type IV2
Brain Ca++-Calmodulin-Dependent Protein Kinase Type IV1 2     caMK2
Calcium/Calmodulin-Dependent Protein Kinase Type IV Catalytic Chain1 2     Calcium/Calmodulin-Dependent Protein Kinase Type IV2
CAM Kinase IV1 2     CAMK3
CAM Kinase- GR1 2     CAMK-GR3
CaM Kinase-GR2 3     CAMKIV3
CaMK IV2 3     EC 2.7.11.173
CaMK-GR2     EC 2.7.118
IV2     

External Ids:    HGNC: 14641   Entrez Gene: 8142   Ensembl: ENSG000001524957   OMIM: 1140805   UniProtKB: Q165663   

Export aliases for CAMK4 gene to outside databases

Previous GC identifers: GC05P110183 GC05P111005 GC05P110590 GC05P110636 GC05P105739


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CAMK4 Gene:
The product of this gene belongs to the serine/threonine protein kinase family, and to the
Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein
kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes,
neurons and male germ cells. (provided by RefSeq, Jul 2008)

GeneCards Summary for CAMK4 Gene: 
CAMK4 (calcium/calmodulin-dependent protein kinase IV) is a protein-coding gene. Diseases associated with CAMK4 include cerebral hypoxia, and allan-herndon-dudley syndrome, and among its related super-pathways are VEGF and S-1P Signaling and Signaling by FGFR. GO annotations related to this gene include calmodulin binding and calmodulin-dependent protein kinase activity. An important paralog of this gene is PNCK.

UniProtKB/Swiss-Prot: KCC4_HUMAN, Q16566
Function: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling
cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as
CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation.
In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny.
In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG
and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of
osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal
expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei
and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP
kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and
ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18

Gene Wiki entry for CAMK4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_034772.6  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CAMK4 gene promoter:
         AhR   AML1a   Pbx1a   Nkx2-5   CREB   FAC1   Pax-3   deltaCREB   HFH-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCAMK4 promoter sequence
   Search SABiosciences Chromatin IP Primers for CAMK4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAMK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q21.3   Ensembl cytogenetic band:  5q22.1   HGNC cytogenetic band: 5q22.1

CAMK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAMK4 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P110587:  view genomic region     (about GC identifiers)

Start:
110,559,351 bp from pter      End:
110,830,584 bp from pter
Size:
271,234 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KCC4_HUMAN, Q16566 (See protein sequence)
Recommended Name: Calcium/calmodulin-dependent protein kinase type IV  
Size: 473 amino acids; 51926 Da
Subunit: Monomer (By similarity). Interacts with protein phosphatase 2A (PPP2CA/PPP2CB); the interaction is
mutually exclusive with binding to Ca(2+)/calmodulin
Subcellular location: Cytoplasm. Nucleus. Note=Localized in hippocampal neuron nuclei. In spermatids, associated
with chromatin and nuclear matrix (By similarity)
Developmental stage: Expressed during differentiation of monocyte-derived dendritic cells (at protein level)
Sequence caution: Sequence=AAH16695.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for CAMK4:
2W4O (3D)    
Secondary accessions: D3DSZ7

Explore the universe of human proteins at neXtProt for CAMK4: NX_Q16566

Explore proteomics data for CAMK4 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by CaMKK1 and CaMKK2 on Thr-200. Dephosphorylated by protein phosphatase 2A. Autophosphorylated on
    Ser-12 and Ser-13
  • UniProtKB: Glycosylation at Ser-189 modulates the phosphorylation of CaMK4 at Thr-200 and negatively regulates its activity
    toward CREB1 in basal conditions and during early inomycin stimulation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16566

  • 4/9 DME Specific Peptides for CAMK4 (Q16566) (see all 9)
     FNARRKL  HPNIIKL  AKDLVRK  GGELFDR 

    CAMK4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CAMK4 Protein Expression
    REFSEQ proteins: NP_001735.1  
    ENSEMBL proteins: 
     ENSP00000426940   ENSP00000422634   ENSP00000282356   ENSP00000423761   ENSP00000424912  
     ENSP00000421606  
    Reactome Protein details: Q16566
    Human Recombinant Protein Products for CAMK4: 
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    OriGene Protein Over-expression Lysate for CAMK4
    OriGene MassSpec for CAMK4 
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    Novus Biologicals CAMK4 Proteins
    Novus Biologicals CAMK4 Lysates
    Sino Biological Recombinant Protein for CAMK4
    Sino Biological Cell Lysate for CAMK4 
    ProSpec Recombinant Protein for CAMK4
    Cloud-Clone Corp. Proteins for CAMK4 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    CAMK4 for ontologies           About GeneDecksing



    CAMK4 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CAMK4
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    Abcam antibodies for CAMK4
    Cloud-Clone Corp. Antibodies for CAMK4 
    ThermoFisher Antibody for CAMK4
    LSBio Antibodies in human, mouse, rat for CAMK4 

    Assay Products for CAMK4: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for CAMK4 
    Cloud-Clone Corp. CLIAs for CAMK4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: calcium/calmodulin-dependent protein kinase IV 
    CAMK1 family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q16566

    ProtoNet protein and cluster: Q16566

    UniProtKB/Swiss-Prot: KCC4_HUMAN, Q16566
    Domain: The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded
    state with the catalytic domain as a pseudosubstrate
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily
    Similarity: Contains 1 protein kinase domain


    CAMK4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCC4_HUMAN, Q16566
    Function: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling
    cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as
    CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation.
    In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny.
    In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG
    and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of
    osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal
    expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei
    and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP
    kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and
    ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that
    relieves intrasteric autoinhibition and allows phosphorylation of Thr-200 within the activation loop by CaMKK1 or
    CaMKK2. Phosphorylation of Thr-200 results in a 10-20-fold increase in total activity to generate
    Ca(2+)/calmodulin-independent activity. Autophosphorylation of the N-terminus Ser-12 and Ser-13 is required for
    full activation. Inactivated by protein phosphatase 2A (PPP2CA/PPP2CB) which dephosphorylates Thr-200, thereby
    terminating autonomous activity and helping to maintain the enzyme in its autoinhibited state

         Genatlas biochemistry entry for CAMK4:
    protein kinase,type IV,calcium/calmodulin dependent,brain

         Enzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.171

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004683calmodulin-dependent protein kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding ----
    GO:0005516calmodulin binding IEA--
         
    CAMK4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CAMK4:
     Decreased substrate adherent c 

         13 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Camk4):
     behavior/neurological  cellular  endocrine/exocrine gland  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  integument  mortality/aging  nervous system 
     normal  reproductive system  skeleton 

    CAMK4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CAMK4: Camk4tm1Tsmi Camk4tm1Arm Camk4tm2Arm Camk4tm1Tch

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CAMK4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CAMK4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAMK4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAMK4 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAMK4
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate CAMK4 (see all 11):
    hsa-miR-30c hsa-miR-586 hsa-miR-30d hsa-miR-885-5p hsa-miR-507 hsa-miR-33a hsa-miR-30a hsa-miR-4274
    SwitchGear 3'UTR luciferase reporter plasmidCAMK4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAMK4
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMK4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CAMK4 About   (see all 42)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1fMLP Pathway
    Alpha-Adrenergic Signaling0.38
    Signal transduction Calcium signaling0.34
    2Signaling by FGFR
    Downstream signaling of activated FGFR0.92
    Downstream signal transduction0.90
    Signaling by FGFR0.92
    Signaling by PDGF0.85
    Signaling by FGFR in disease0.91
    Signaling by EGFR0.84
    DAP12 signaling0.91
    Signaling by EGFR in Cancer0.83
    3Ca-dependent events
    DAG and IP3 signaling0.94
    PLCG1 events in ERBB2 signaling0.91
    EGFR interacts with phospholipase C-gamma0.94
    PLC beta mediated events0.65
    PLC-gamma1 signalling0.94
    G-protein mediated events0.64
    Ca-dependent events0.93
    Phospholipase C-mediated cascade0.57
    4Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.67
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    5CaMK IV-mediated phosphorylation of CREB
    CaMK IV-mediated phosphorylation of CREB0.75
    Activation of CaMK IV0.67
    CREB phosphorylation through the activation of CaMKK0.75

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/6 EMD Millipore Pathways for CAMK4 (see all 6)
        Signal transduction Calcium signaling
    Immune response Function of MEF2 in T lymphocytes
    Signal transduction IP3 signaling
    Signal transduction cAMP signaling
    Transcription CREB pathway

    5/16 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CAMK4 (see all 16)
        PKA Signaling
    IGF1R Signaling
    Intracellular Calcium Signaling
    CRHR Pathway
    Thrombin Signaling

    2 Cell Signaling Technology (CST) Pathways for CAMK4
        Ca, cAMP and Lipid Signaling
    Neuroscience

    5/6 GeneGo (Thomson Reuters) Pathways for CAMK4 (see all 6)
        Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Signal transduction cAMP signaling
    Transcription CREB pathway
    Immune response Function of MEF2 in T lymphocytes
    Signal transduction Calcium signaling

    5/10 BioSystems Pathways for CAMK4 (see all 10)
        Mitochondrial Gene Expression
    Hypothetical Network for Drug Addiction
    Calcium Regulation in the Cardiac Cell
    BDNF signaling pathway
    Energy Metabolism

    1 Sino Biological Pathway for CAMK4 
        EGFR Signaling Pathway

    5/36        Reactome Pathways for CAMK4 (see all 36)
        Signaling by EGFR in Cancer
    Post NMDA receptor activation events
    Downstream signal transduction
    Activation of CaMK IV
    Signal Transduction


    5/7         Kegg Pathways  (Kegg details for CAMK4) (see all 7):
        Calcium signaling pathway
    Osteoclast differentiation
    Long-term potentiation
    Neurotrophin signaling pathway
    Cholinergic synapse


    CAMK4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CAMK4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/25 Interacting proteins for CAMK4 (Q165663 ENSP000002823564) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC4P565243, ENSP000002646064I2D: score=3 STRING: ENSP00000264606
    CAMKK2Q96RR43, ENSP000003127414I2D: score=2 STRING: ENSP00000312741
    GAPDHP044063, ENSP000002292394I2D: score=2 STRING: ENSP00000229239
    NOS1P294753, ENSP000003207584I2D: score=1 STRING: ENSP00000320758
    CAMKK1Q8N5S93, ENSP000001581664I2D: score=1 STRING: ENSP00000158166
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002372NOT myeloid dendritic cell cytokine production IMP17909078
    GO:0006468protein phosphorylation TAS8089075
    GO:0006913nucleocytoplasmic transport IEA--
    GO:0006954inflammatory response IEA--
    GO:0007165signal transduction TAS--

    CAMK4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CAMK4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CAMK4 (KCC4)

    3 HMDB Compounds for CAMK4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--

    2 DrugBank Compounds for CAMK4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one-- --target--10592235
    5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE-- --target--10592235

    10/13 Novoseek inferred chemical compound relationships for CAMK4 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    syntide-2 86.4 1 15262326 (1)
    calcium 53.5 41 1645731 (3), 10191497 (2), 20171262 (2), 19711354 (2) (see all 27)
    threonine 45.8 5 19538941 (1), 10932193 (1), 15143065 (1), 15262326 (1)
    serine 42.6 7 1645731 (1), 19538941 (1), 10932193 (1), 1901412 (1) (see all 6)
    cyclic amp 41.8 2 17428448 (1), 12234621 (1)
    ionomycin 33.2 1 7925472 (1)
    atp 25.8 1 8194751 (1)
    retinoid 19.4 1 11559707 (1)
    nmda 12.7 2 19633294 (1)
    magnesium 0 1 8586621 (1)

    Search CenterWatch for drugs/clinical trials and news about CAMK4 / KCC4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CAMK4 gene: 
    NM_001744.4  

    Unigene Cluster for CAMK4:

    Calcium/calmodulin-dependent protein kinase IV
    Hs.591269  [show with all ESTs]
    Unigene Representative Sequence: NM_001744
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508074 ENST00000512453 ENST00000282356(uc003kpf.3 uc010jbv.3)
    ENST00000504544 ENST00000515231 ENST00000509408 ENST00000514007 ENST00000504090
    ENST00000502916 ENST00000505763 ENST00000509645(uc003kpg.3) ENST00000510858
    ENST00000512890

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    Additional mRNA sequence: 

    AK311662.1 AK312840.1 BC016695.1 BC025687.1 D30742.1 L17000.1 L24959.1 

    8 DOTS entries:

    DT.408507  DT.311969  DT.120813754  DT.120813794  DT.95161510  DT.120813801  DT.97771009  DT.99991905 

    24/39 AceView cDNA sequences (see all 39):

    CD558096 AL134969 BP379092 BC025687 AA455227 AI627334 D30742 BX376712 
    L24959 CR615443 AA361421 NM_001744 AL119808 CR622299 CB141413 BM986829 
    BC016695 AL833368 BP371266 BX506878 BG719489 BU165729 AA465605 BI561151 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CAMK4    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c
    SP1:              -     -                           
    SP2:                                                
    SP3:                                                


    ECgene alternative splicing isoforms for CAMK4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CAMK4 expression in normal human tissues (normalized intensities)      CAMK4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCCATATG
    CAMK4 Expression
    About this image


    CAMK4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Testis (Reproductive System)
             Elongated Spermatid Seminiferous Tubules
     
     Gonad
             Elongated Spermatid Seminiferous Tubules
     
     Blood (Hematopoietic System)
             Small Pre B-Cells Hematopoietic Bone Marrow
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Thymus (Hematopoietic System)

    See CAMK4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CAMK4

    SOURCE GeneReport for Unigene cluster: Hs.591269

    UniProtKB/Swiss-Prot: KCC4_HUMAN, Q16566
    Tissue specificity: Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CAMK4 gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Camk41 , 5 calcium/calmodulin-dependent protein kinase IV1, 5 83.83(n)1
    82.4(a)1
      18 (18.15 cM)5
    123261  NM_009793.31  NP_033923.21 
     329390415 
    chicken
    (Gallus gallus)
    Aves CAMK41 calcium/calmodulin-dependent protein kinase IV 76.71(n)
    80(a)
      723973  NM_001034813.1  NP_001029985.1 
    lizard
    (Anolis carolinensis)
    Reptilia CAMK46
    --
    Uncharacterized protein
    74(a)
    73(a)
    1 ↔ 1
    possible ortholog
    GL343193.1(6299952-6426516)
    GL343756.1(217795-264032)
    African clawed frog
    (Xenopus laevis)
    Amphibia camk4-A2 calcium/calmodulin-dependent protein kinase IV 81.16(n)    AF316822.1 
    zebrafish
    (Danio rerio)
    Actinopterygii camk41 calcium/calmodulin-dependent protein kinase IV 72.71(n)
    81.04(a)
      550270  NM_001017607.1  NP_001017607.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CMK26
    CMK16
    Calmodulin-dependent protein kinase; may play a ro...
    Calmodulin-dependent protein kinase; may play a ro...
    28(a)
    28(a)
    many ↔ many
    many ↔ many
    XV(294777-296120)
    VI(172537-173877)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CPK331 calcium-dependent protein kinase 33 50.74(n)
    42.27(a)
      841492  NM_103952.3  NP_175485.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g05151001 hypothetical protein 50.78(n)
    42.33(a)
      4343373  NM_001066310.1  NP_001059775.1 


    ENSEMBL Gene Tree for CAMK4 (if available)
    TreeFam Gene Tree for CAMK4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CAMK4 gene
    PNCK2  CAMK1G2  PSKH22  PHKG22  CAMK2A2  CAMK1D2  PSKH12  CAMK2D2  
    PHKG12  CAMKV2  CAMK2G2  CAMK2B2  CAMK12  
    18/40 SIMAP similar genes for CAMK4 using alignment to 4 protein entries:     KCC4_HUMAN (see all proteins) (see all similar genes):
    PNCK    CAMK1    CAMK1D    PSKH1    RPS6KA2    CAMK1G
    DCLK3    RPS6KA4    MGC45428    MYLK4    PSKH2    RPS6KA3
    RPS6KA1    CAMKV    DAPK2    DCLK2    TTN    CAMK2D

    CAMK4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5356 SNPs in CAMK4 are shown (see all 5356)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0406074
    A lung large cell carcinoma sample4--see VAR_0406072 I M mis40--------
    VAR_0406044
    A lung adenocarcinoma sample4--see VAR_0406042 E G mis40--------
    rs21628931,2
    C,F,A,H--105737116(-) aaataC/Tagatg 1 -- us2k1 tfbs315Minor allele frequency- T:0.27NS EA NA WA CSA 673
    rs1819174141,2
    --105737128(+) CAGGGA/GCTCTC 1 -- us2k10--------
    rs1862345791,2
    --105737172(+) TGTCAG/TATCAG 1 -- us2k10--------
    rs1906445011,2
    --105737302(+) ACCCCC/TAGATA 1 -- us2k10--------
    rs769015901,2
    C,F--105737464(+) TCTTCC/ACCACC 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1828221261,2
    --105737489(+) AAAATC/TATCTT 1 -- us2k10--------
    rs763666941,2
    F--105737517(+) GGTGCC/TGAAAA 1 -- us2k11Minor allele frequency- T:0.09NA 120
    rs1855675031,2
    --105737525(+) AAAGGC/TTGGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CAMK4 (110559351 - 110809351 bp, first 250kb of CAMK4)

    Structural Variations
         Database of Genomic Variants (DGV) 10/17 variations for CAMK4 (see all 17):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2647908CNV Deletion19546169
    esv2730592CNV Deletion23290073
    esv4209CNV Deletion18987735
    esv2313843CNV Deletion18987734
    esv1341497CNV Deletion17803354
    dgv1038e199CNV Deletion23128226
    esv274515CNV Insertion20981092
    esv269264CNV Insertion20981092
    esv271918CNV Insertion20981092
    esv8952CNV Loss19470904


    Human Gene Mutation Database (HGMD): CAMK4
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 114080    OMIM disorders: --

    20/21 diseases for CAMK4 (see all 21):    About MalaCards
    cerebral hypoxia    allan-herndon-dudley syndrome    blastoma    fibromatosis
    hypoxia    alcohol dependence    azoospermia    narcolepsy
    gingivitis    cerebritis    endometrial carcinoma    alcoholism
    neuronitis    ovarian cancer    systemic lupus erythematosus    neuroblastoma
    lupus erythematosus    mental retardation    thyroiditis    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for CAMK4:
    Allan-Herndon-Dudley syndrome

    CAMK4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for CAMK4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cerebral hypoxia 51.2 1 15262326 (1)

    Genetic Association Database (GAD): CAMK4
    Human Genome Epidemiology (HuGE) Navigator: CAMK4 (5 documents)

    Export disorders for CAMK4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CAMK4 gene, integrated from 9 sources (see all 145):
    (articles sorted by number of sources associating them with CAMK4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1. (PubMed id 8107230)1, 2, 9 Mosialos G....Chatila T.A. (1994)
    2. Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex. (PubMed id 15143065)1, 2, 9 Anderson K.A.... Means A.R. (2004)
    3. The cDNA sequence and characterization of the Ca2+/calmodulin- dependent protein kinase-Gr from human brain and thymus. (PubMed id 8194751)1, 2, 9 Bland M.M.... Ohmstede C.A. (1994)
    4. cDNA cloning and expression of human calmodulin-dependent protein kinase IV. (PubMed id 8089075)1, 2, 9 Kitani T.... Fujisawa H. (1994)
    5. Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade. (PubMed id 8855261)1, 2, 9 Enslen H....Soderling T.R. (1996)
    6. Association study on long-living individuals from Sou thern Italy identifies rs10491334 in the CAMKIV gene that regulates survival pr oteins. (PubMed id 21612516)1, 4 Malovini A....Puca A.A. (2011)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    8. Evaluation of 172 candidate polymorphisms for associa tion with oligozoospermia or azoospermia in a large cohort of men of European d escent. (PubMed id 20378615)1, 4 Aston K.I....Carrell D.T. (2010)
    9. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (2010)
    10. Regulation of calcium/calmodulin-dependent kinase IV by O-GlcNAc modification. (PubMed id 19506079)1, 2 Dias W.B....Hart G.W. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 814 HGNC: 1464 AceView: CAMK4 Ensembl:ENSG00000152495 euGenes: HUgn814
    ECgene: CAMK4 Kegg: 814 H-InvDB: CAMK4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CAMK4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CAMK4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CAMK4 gene:
    Search GeneIP for patents involving CAMK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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