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CAMK4 Gene

protein-coding   GIFtS: 73
GCID: GC05P110587

Calcium/Calmodulin-Dependent Protein Kinase IV

  See CAMK4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calcium/Calmodulin-Dependent Protein Kinase IV1 2     Brain Ca(2+)-Calmodulin-Dependent Protein Kinase Type IV2
Brain Ca++-Calmodulin-Dependent Protein Kinase Type IV1 2     caMK2
Calcium/Calmodulin-Dependent Protein Kinase Type IV Catalytic Chain1 2     Calcium/Calmodulin-Dependent Protein Kinase Type IV2
CAM Kinase IV1 2     CAMK3
CAM Kinase- GR1 2     CAMK-GR3
CaM Kinase-GR2 3     CAMKIV3
CaMK IV2 3     EC 2.7.11.173
CaMK-GR2     EC 2.7.118
IV2     

External Ids:    HGNC: 14641   Entrez Gene: 8142   Ensembl: ENSG000001524957   OMIM: 1140805   UniProtKB: Q165663   

Export aliases for CAMK4 gene to outside databases

Previous GC identifers: GC05P110183 GC05P111005 GC05P110590 GC05P110636 GC05P105739


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CAMK4 Gene:
The product of this gene belongs to the serine/threonine protein kinase family, and to the
Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein
kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes,
neurons and male germ cells. (provided by RefSeq, Jul 2008)

GeneCards Summary for CAMK4 Gene:
CAMK4 (calcium/calmodulin-dependent protein kinase IV) is a protein-coding gene. Diseases associated with CAMK4 include cerebral hypoxia, and allan-herndon-dudley syndrome. GO annotations related to this gene include calmodulin binding and calmodulin-dependent protein kinase activity. An important paralog of this gene is PNCK.

UniProtKB/Swiss-Prot: KCC4_HUMAN, Q16566
Function: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling
cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as
CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation.
In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny.
In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG
and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of
osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal
expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei
and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP
kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and
ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18

Gene Wiki entry for CAMK4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the CAMK4 gene promoter:
         AhR   AML1a   Pbx1a   Nkx2-5   CREB   FAC1   Pax-3   deltaCREB   HFH-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCAMK4 promoter sequence
   Search Chromatin IP Primers for CAMK4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CAMK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q21.3   Ensembl cytogenetic band:  5q22.1   HGNC cytogenetic band: 5q22.1

CAMK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAMK4 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P110587:  view genomic region     (about GC identifiers)

Start:
110,559,351 bp from pter      End:
110,830,584 bp from pter
Size:
271,234 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KCC4_HUMAN, Q16566 (See protein sequence)
Recommended Name: Calcium/calmodulin-dependent protein kinase type IV  
Size: 473 amino acids; 51926 Da
Subunit: Monomer (By similarity). Interacts with protein phosphatase 2A (PPP2CA/PPP2CB); the interaction is
mutually exclusive with binding to Ca(2+)/calmodulin
Developmental stage: Expressed during differentiation of monocyte-derived dendritic cells (at protein level)
Sequence caution: Sequence=AAH16695.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for CAMK4:
2W4O (3D)    
Secondary accessions: D3DSZ7

Explore the universe of human proteins at neXtProt for CAMK4: NX_Q16566

Explore proteomics data for CAMK4 at MOPED

Post-translational modifications: 

  • Phosphorylated by CaMKK1 and CaMKK2 on Thr-200. Dephosphorylated by protein phosphatase 2A. Autophosphorylated on
    Ser-12 and Ser-131
  • Glycosylation at Ser-189 modulates the phosphorylation of CaMK4 at Thr-200 and negatively regulates its activity
    toward CREB1 in basal conditions and during early inomycin stimulation1
  • Ubiquitination2 at Lys190, Lys303
  • Glycosylation2 at Thr57, Ser58, Ser137, Ser189, Ser344, Ser345, Ser356
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CAMK4 (Q16566) (see all 9)
     FNARRKL  HPNIIKL  AKDLVRK  GGELFDR 


    See CAMK4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001735.1  
    ENSEMBL proteins: 
     ENSP00000426940   ENSP00000422634   ENSP00000282356   ENSP00000423761   ENSP00000424912  
     ENSP00000421606  
    Reactome Protein details: Q16566

    CAMK4 Human Recombinant Protein Products:

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    Novus Biologicals CAMK4 Proteins
    Novus Biologicals CAMK4 Lysates
    Sino Biological Recombinant Protein for CAMK4
    Sino Biological Cell Lysate for CAMK4
    ProSpec Recombinant Protein for CAMK4
    Cloud-Clone Corp. Proteins for CAMK4

     
    Search eBioscience for Proteins for CAMK4 

    CAMK4 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CAMK4
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    Abcam antibodies for CAMK4
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    LSBio Antibodies in human, mouse, rat for CAMK4

    CAMK4 Assay Products:

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    GenScript Custom Assay Services for CAMK4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CAMK4
    Cloud-Clone Corp. CLIAs for CAMK4
    Search eBioscience for ELISAs for CAMK4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: calcium/calmodulin-dependent protein kinase IV
    CAMK1 family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q16566

    ProtoNet protein and cluster: Q16566

    UniProtKB/Swiss-Prot: KCC4_HUMAN, Q16566
    Domain: The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded
    state with the catalytic domain as a pseudosubstrate
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with CAMK4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCC4_HUMAN, Q16566
    Function: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling
    cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as
    CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation.
    In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny.
    In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG
    and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of
    osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal
    expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei
    and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP
    kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and
    ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that
    relieves intrasteric autoinhibition and allows phosphorylation of Thr-200 within the activation loop by CaMKK1 or
    CaMKK2. Phosphorylation of Thr-200 results in a 10-20-fold increase in total activity to generate
    Ca(2+)/calmodulin-independent activity. Autophosphorylation of the N-terminus Ser-12 and Ser-13 is required for
    full activation. Inactivated by protein phosphatase 2A (PPP2CA/PPP2CB) which dephosphorylates Thr-200, thereby
    terminating autonomous activity and helping to maintain the enzyme in its autoinhibited state

         Genatlas biochemistry entry for CAMK4:
    protein kinase,type IV,calcium/calmodulin dependent,brain

         Enzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.171

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004683calmodulin-dependent protein kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding ----
    GO:0005516calmodulin binding IEA--
         
    Find genes that share ontologies with CAMK4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CAMK4:
     Decreased substrate adherent c 

         13 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Camk4):
     behavior/neurological  cellular  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  mortality/aging  nervous system 
     normal  reproductive system  skeleton 

    Find genes that share phenotypes with CAMK4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CAMK4: Camk4tm1Tsmi Camk4tm1Arm Camk4tm2Arm Camk4tm1Tch

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CAMK4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CAMK4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAMK4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAMK4

    miRNA
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    miRTarBase miRNAs that target CAMK4:
    hsa-mir-215-5p (MIRT024679), hsa-mir-26b-5p (MIRT030257), hsa-mir-192-5p (MIRT026869)

    Block miRNA regulation of human, mouse, rat CAMK4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CAMK4 (see all 11):
    hsa-miR-30c hsa-miR-586 hsa-miR-30d hsa-miR-885-5p hsa-miR-507 hsa-miR-33a hsa-miR-30a hsa-miR-4274
    SwitchGear 3'UTR luciferase reporter plasmidCAMK4 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: CAMK4 (NM_001744)
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    Addgene plasmids for CAMK4 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KCC4_HUMAN, Q16566: Cytoplasm. Nucleus. Note=Localized in hippocampal neuron nuclei. In spermatids, associated
    with chromatin and nuclear matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    Find genes that share ontologies with CAMK4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CAMK4 About   (see all 41)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Ca-dependent events
    DAG and IP3 signaling0.94
    PLCG1 events in ERBB2 signaling0.92
    EGFR interacts with phospholipase C-gamma0.94
    PLC beta mediated events0.67
    PLC-gamma1 signalling0.94
    G-protein mediated events0.65
    CaM pathway0.93
    Phospholipase C-mediated cascade0.59
    2Post NMDA receptor activation events
    Post NMDA receptor activation events0.90
    Activation of CaMK IV0.00
    Activation of NMDA receptor upon glutamate binding and postsynaptic events0.90
    CaMK IV-mediated phosphorylation of CREB0.00
    Long-term potentiation0.35
    CREB phosphorylation through the activation of CaMKK0.00
    3Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82
    4Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77


    Find genes that share SuperPaths with CAMK4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CAMK4 (see all 16)
        PKA Signaling
    IGF1R Signaling
    Intracellular Calcium Signaling
    CRHR Pathway
    Thrombin Signaling

    2 Cell Signaling Technology (CST) Pathways for CAMK4
        Ca, cAMP and Lipid Signaling
    Neuroscience

    Selected GeneGo (Thomson Reuters) Pathways for CAMK4 (see all 6)
        Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Signal transduction cAMP signaling
    Transcription CREB pathway
    Immune response Function of MEF2 in T lymphocytes
    Signal transduction Calcium signaling

    Selected BioSystems Pathways for CAMK4 (see all 10)
        Mitochondrial Gene Expression
    Hypothetical Network for Drug Addiction
    Calcium Regulation in the Cardiac Cell
    BDNF signaling pathway
    Energy Metabolism

    1 Sino Biological Pathway for CAMK4
        EGFR Signaling Pathway

    4 Reactome Pathways for CAMK4
        Activation of CaMK IV
    Transcriptional activation of mitochondrial biogenesis
    CaMK IV-mediated phosphorylation of CREB
    CREB phosphorylation through the activation of CaMKK


    Selected Kegg Pathways  (Kegg details for CAMK4) (see all 8):
        Calcium signaling pathway
    Osteoclast differentiation
    Long-term potentiation
    Neurotrophin signaling pathway
    Cholinergic synapse

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CAMK4
    Interactions:

        GeneGlobe Interaction Network for CAMK4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CAMK4 (Q165663 ENSP000002823564) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC4P565243, ENSP000002646064I2D: score=3 STRING: ENSP00000264606
    CAMKK2Q96RR43, ENSP000003127414I2D: score=2 STRING: ENSP00000312741
    GAPDHP044063, ENSP000002292394I2D: score=2 STRING: ENSP00000229239
    NOS1P294753, ENSP000003207584I2D: score=1 STRING: ENSP00000320758
    CAMKK1Q8N5S93, ENSP000001581664I2D: score=1 STRING: ENSP00000158166
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002372NOT myeloid dendritic cell cytokine production IMP17909078
    GO:0006468protein phosphorylation TAS8089075
    GO:0006913nucleocytoplasmic transport IEA--
    GO:0006954inflammatory response IEA--
    GO:0007165signal transduction TAS--

    Find genes that share ontologies with CAMK4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CAMK4 (KCC4)

    3 HMDB Compounds for CAMK4    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--

    2 DrugBank Compounds for CAMK4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one-- --target--10592235
    5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for CAMK4 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    syntide-2 86.4 1 15262326 (1)
    calcium 53.5 41 1645731 (3), 10191497 (2), 20171262 (2), 19711354 (2) (see all 27)
    threonine 45.8 5 19538941 (1), 10932193 (1), 15143065 (1), 15262326 (1)
    serine 42.6 7 1645731 (1), 19538941 (1), 10932193 (1), 1901412 (1) (see all 6)
    cyclic amp 41.8 2 17428448 (1), 12234621 (1)
    ionomycin 33.2 1 7925472 (1)
    atp 25.8 1 8194751 (1)
    retinoid 19.4 1 11559707 (1)
    nmda 12.7 2 19633294 (1)
    magnesium 0 1 8586621 (1)



    Find genes that share compounds with CAMK4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CAMK4 gene: 
    NM_001744.4  

    Unigene Cluster for CAMK4:

    Calcium/calmodulin-dependent protein kinase IV
    Hs.591269  [show with all ESTs]
    Unigene Representative Sequence: NM_001744
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508074 ENST00000512453 ENST00000282356(uc003kpf.3 uc010jbv.3)
    ENST00000504544 ENST00000515231 ENST00000509408 ENST00000514007 ENST00000504090
    ENST00000502916 ENST00000505763 ENST00000509645(uc003kpg.3) ENST00000510858
    ENST00000512890
    miRNA
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    Additional mRNA sequence: 

    AK311662.1 AK312840.1 BC016695.1 BC025687.1 D30742.1 L17000.1 L24959.1 

    8 DOTS entries:

    DT.408507  DT.311969  DT.120813754  DT.120813794  DT.95161510  DT.120813801  DT.97771009  DT.99991905 

    Selected AceView cDNA sequences (see all 39):

    CR622299 AA455227 NM_001744 AA361421 BC025687 L24959 CD558096 CR615443 
    AL119808 BX376712 BM986829 AL134969 D30742 CB141413 BP379092 AI627334 
    BP371266 BC016695 BI561151 BI548325 BU165729 BX506878 CD557572 L17000 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CAMK4    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c
    SP1:              -     -                           
    SP2:                                                
    SP3:                                                


    ECgene alternative splicing isoforms for CAMK4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CAMK4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCCATATG
    CAMK4 Expression
    About this image


    CAMK4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Spermatid Seminiferous Tubules
     
     Gonad
             Spermatid Seminiferous Tubules
     
     Lung (Respiratory System)
             Basal Cells Trachea
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Blood (Hematopoietic System)
             Small Pre B-Cells Hematopoietic Bone Marrow
    CAMK4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CAMK4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591269

    UniProtKB/Swiss-Prot: KCC4_HUMAN, Q16566
    Tissue specificity: Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CAMK4 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Camk41 , 5 calcium/calmodulin-dependent protein kinase IV1, 5 83.26(n)1
    81.97(a)1
      18 (18.15 cM)5
    123261  NM_009793.31  NP_033923.21 
     329390415 
    chicken
    (Gallus gallus)
    Aves CAMK41 calcium/calmodulin-dependent protein kinase IV 76.61(n)
    80.39(a)
      723973  NM_001034813.1  NP_001029985.1 
    lizard
    (Anolis carolinensis)
    Reptilia CAMK46
    calcium/calmodulin-dependent protein kinase IV
    75(a)
    1 ↔ 1
    GL343193.1(6299952-6426516)
    African clawed frog
    (Xenopus laevis)
    Amphibia camk4-A2 calcium/calmodulin-dependent protein kinase IV 81.16(n)    AF316822.1 
    zebrafish
    (Danio rerio)
    Actinopterygii camk41 calcium/calmodulin-dependent protein kinase IV 72.07(n)
    79.12(a)
      550270  NM_001017607.1  NP_001017607.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CaMKI6
    Calcium/calmodulin-dependent protein kinase I
    36(a)
    1 ↔ 1
    4(466130-474573)
    worm
    (Caenorhabditis elegans)
    Secernentea cmk-16
    Protein CMK-1 (cmk-1) mRNA, complete cds
    42(a)
    1 ↔ 1
    IV(1824528-1834029) WBGene00000553
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CMK16
    CMK26
    Calmodulin-dependent protein kinase; may play a ro...
    Calmodulin-dependent protein kinase; may play a ro...
    29(a)
    26(a)
    many ↔ many
    many ↔ many
    VI(172537-173877) YFR014C
    XV(294777-296120) YOL016C


    ENSEMBL Gene Tree for CAMK4 (if available)
    TreeFam Gene Tree for CAMK4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CAMK4 gene
    PNCK2  CAMK1G2  PSKH22  DCX2  DCLK22  CAMK2A2  CAMK1D2  DCLK12  
    PSKH12  CAMK2D2  DCLK32  CAMKV2  CAMK2G2  CAMK2B2  CAMK12  
    Selected SIMAP similar genes for CAMK4 using alignment to 4 protein entries:     KCC4_HUMAN (see all proteins) (see all similar genes):
    PNCK    CAMK1    CAMK1D    PSKH1    RPS6KA2    CAMK1G
    DCLK3    RPS6KA4    MGC45428    MYLK4    PSKH2    RPS6KA3
    RPS6KA1    CAMKV    DAPK2    DCLK2    TTN    CAMK2D

    Find genes that share paralogs with CAMK4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CAMK4 (see all 5356)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0406074
    A lung large cell carcinoma sample4--see VAR_0406072 I M mis40--------
    VAR_0406044
    A lung adenocarcinoma sample4--see VAR_0406042 E G mis40--------
    rs21628931,2
    C,F,A,H--105737116(-) aaataC/Tagatg 1 -- us2k1 tfbs315Minor allele frequency- T:0.27NS EA NA WA CSA 673
    rs1819174141,2
    --105737128(+) CAGGGA/GCTCTC 1 -- us2k10--------
    rs1862345791,2
    --105737172(+) TGTCAG/TATCAG 1 -- us2k10--------
    rs1906445011,2
    --105737302(+) ACCCCC/TAGATA 1 -- us2k10--------
    rs769015901,2
    C,F--105737464(+) TCTTCC/ACCACC 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1828221261,2
    --105737489(+) AAAATC/TATCTT 1 -- us2k10--------
    rs763666941,2
    F--105737517(+) GGTGCC/TGAAAA 1 -- us2k11Minor allele frequency- T:0.09NA 120
    rs1855675031,2
    --105737525(+) AAAGGC/TTGGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CAMK4 (110559351 - 110809351 bp, first 250kb of CAMK4)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CAMK4 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2647908CNV Deletion19546169
    esv2730592CNV Deletion23290073
    esv4209CNV Deletion18987735
    esv2313843CNV Deletion18987734
    esv1341497CNV Deletion17803354
    dgv1038e199CNV Deletion23128226
    esv274515CNV Insertion20981092
    esv269264CNV Insertion20981092
    esv271918CNV Insertion20981092
    esv8952CNV Loss19470904

    Human Gene Mutation Database (HGMD): CAMK4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CAMK4
    DNA2.0 Custom Variant and Variant Library Synthesis for CAMK4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 114080    OMIM disorders: --

    2 diseases for CAMK4:    
    About MalaCards
    cerebral hypoxia    allan-herndon-dudley syndrome

    1 disease from the University of Copenhagen DISEASES database for CAMK4:
    Allan-Herndon-Dudley syndrome

    Find genes that share disorders with CAMK4           About GenesLikeMe

    1 Novoseek inferred disease relationship for CAMK4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cerebral hypoxia 51.2 1 15262326 (1)

    Genetic Association Database (GAD): CAMK4
    Human Genome Epidemiology (HuGE) Navigator: CAMK4 (5 documents)

    Export disorders for CAMK4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CAMK4 gene, integrated from 10 sources (see all 149):
    (articles sorted by number of sources associating them with CAMK4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1. (PubMed id 8107230)1, 2, 9 Mosialos G....Chatila T.A. (J. Virol. 1994)
    2. Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex. (PubMed id 15143065)1, 2, 9 Anderson K.A.... Means A.R. (J. Biol. Chem. 2004)
    3. The cDNA sequence and characterization of the Ca2+/calmodulin- dependent protein kinase-Gr from human brain and thymus. (PubMed id 8194751)1, 2, 9 Bland M.M.... Ohmstede C.A. (Gene 1994)
    4. cDNA cloning and expression of human calmodulin-dependent protein kinase IV. (PubMed id 8089075)1, 2, 9 Kitani T.... Fujisawa H. (J. Biochem. 1994)
    5. Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade. (PubMed id 8855261)1, 2, 9 Enslen H.... Soderling T.R. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    6. Association study on long-living individuals from Southern Italy identifies rs10491334 in the CAMKIV gene that regulates survival proteins. (PubMed id 21612516)1, 4 Malovini A....Puca A.A. (Rejuvenation Res 2011)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PubMed id 20378615)1, 4 Aston K.I....Carrell D.T. (Hum. Reprod. 2010)
    9. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    10. Regulation of calcium/calmodulin-dependent kinase IV by O-GlcNAc modification. (PubMed id 19506079)1, 2 Dias W.B.... Hart G.W. (J. Biol. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 814 HGNC: 1464 AceView: CAMK4 Ensembl:ENSG00000152495 euGenes: HUgn814
    ECgene: CAMK4 Kegg: 814 H-InvDB: CAMK4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CAMK4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CAMK4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CAMK4 gene:
    Search GeneIP for patents involving CAMK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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