Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CAMK4 Gene

Aliases for CAMK4 Gene

  • Calcium/Calmodulin-Dependent Protein Kinase IV 2 3
  • Calcium/Calmodulin-Dependent Protein Kinase Type IV Catalytic Chain 2 3
  • Brain Ca++-Calmodulin-Dependent Protein Kinase Type IV 2 3
  • CAM Kinase- GR 2 3
  • CAM Kinase IV 2 3
  • CaM Kinase-GR 3 4
  • CaMK IV 3 4
  • CaMK-GR 3 4
  • CaMK 3 4
  • Brain Ca(2+)-Calmodulin-Dependent Protein Kinase Type IV 3
  • EC 2.7.11.17 4
  • EC 2.7.11 63
  • CAMKIV 4
  • IV 3

External Ids for CAMK4 Gene

Previous GeneCards Identifiers for CAMK4 Gene

  • GC05P110183
  • GC05P111005
  • GC05P110590
  • GC05P110636
  • GC05P110587
  • GC05P105739

Summaries for CAMK4 Gene

Entrez Gene Summary for CAMK4 Gene

  • The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAMK4 Gene

CAMK4 (Calcium/Calmodulin-Dependent Protein Kinase IV) is a Protein Coding gene. Diseases associated with CAMK4 include cerebral hypoxia. Among its related pathways are Immune System and DAG and IP3 signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is DCX.

UniProtKB/Swiss-Prot for CAMK4 Gene

  • Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on Ser-133 in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.

Gene Wiki entry for CAMK4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMK4 Gene

Genomics for CAMK4 Gene

Regulatory Elements for CAMK4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CAMK4 Gene

Chromosome:
5
Start:
111,223,653 bp from pter
End:
111,494,886 bp from pter
Size:
271,234 bases
Orientation:
Plus strand

Genomic View for CAMK4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for CAMK4 Gene

Proteins for CAMK4 Gene

  • Protein details for CAMK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16566-KCC4_HUMAN
    Recommended name:
    Calcium/calmodulin-dependent protein kinase type IV
    Protein Accession:
    Q16566
    Secondary Accessions:
    • D3DSZ7

    Protein attributes for CAMK4 Gene

    Size:
    473 amino acids
    Molecular mass:
    51926 Da
    Quaternary structure:
    • Monomer (By similarity). Interacts with protein phosphatase 2A (PPP2CA/PPP2CB); the interaction is mutually exclusive with binding to Ca(2+)/calmodulin.
    SequenceCaution:
    • Sequence=AAH16695.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CAMK4 Gene

neXtProt entry for CAMK4 Gene

Proteomics data for CAMK4 Gene at MOPED

Selected DME Specific Peptides for CAMK4 Gene

Post-translational modifications for CAMK4 Gene

  • Glycosylation at Ser-189 modulates the phosphorylation of CaMK4 at Thr-200 and negatively regulates its activity toward CREB1 in basal conditions and during early inomycin stimulation.
  • Phosphorylated by CaMKK1 and CaMKK2 on Thr-200. Dephosphorylated by protein phosphatase 2A. Autophosphorylated on Ser-12 and Ser-13.
  • Ubiquitination at Lys 190 and Lys 303
  • Glycosylation at Thr 57, Ser 58, Ser 137, Ser 189, Ser 344, Ser 345, and Ser 356
  • Modification sites at PhosphoSitePlus

Other Protein References for CAMK4 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CAMK4 (CaMK4)

Domains & Families for CAMK4 Gene

Gene Families for CAMK4 Gene

Suggested Antigen Peptide Sequences for CAMK4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16566

UniProtKB/Swiss-Prot:

KCC4_HUMAN :
  • The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Domain:
  • The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
genes like me logo Genes that share domains with CAMK4: view

Function for CAMK4 Gene

Molecular function for CAMK4 Gene

GENATLAS Biochemistry:
protein kinase,type IV,calcium/calmodulin dependent,brain
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows phosphorylation of Thr-200 within the activation loop by CaMKK1 or CaMKK2. Phosphorylation of Thr-200 results in a 10-20-fold increase in total activity to generate Ca(2+)/calmodulin-independent activity. Autophosphorylation of the N-terminus Ser-12 and Ser-13 is required for full activation. Inactivated by protein phosphatase 2A (PPP2CA/PPP2CB) which dephosphorylates Thr-200, thereby terminating autonomous activity and helping to maintain the enzyme in its autoinhibited state.
UniProtKB/Swiss-Prot Function:
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on Ser-133 in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.

Enzyme Numbers (IUBMB) for CAMK4 Gene

Gene Ontology (GO) - Molecular Function for CAMK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004683 calmodulin-dependent protein kinase activity IDA 8107230
GO:0005515 protein binding --
GO:0005516 calmodulin binding IBA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CAMK4: view
genes like me logo Genes that share phenotypes with CAMK4: view

Animal Models for CAMK4 Gene

MGI Knock Outs for CAMK4:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAMK4

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for CAMK4 Gene

Localization for CAMK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMK4 Gene

Cytoplasm. Nucleus. Note=Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAMK4 Gene COMPARTMENTS Subcellular localization image for CAMK4 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for CAMK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CAMK4: view

Pathways & Interactions for CAMK4 Gene

SuperPathways for CAMK4 Gene

Superpath Contained pathways
1 Interleukin receptor SHC signaling
2 DAG and IP3 signaling
3 Post NMDA receptor activation events
4 Activation of cAMP-Dependent PKA
5 CREB Pathway
genes like me logo Genes that share pathways with CAMK4: view

SIGNOR curated interactions for CAMK4 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for CAMK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002372 NOT myeloid dendritic cell cytokine production IMP 17909078
GO:0006468 protein phosphorylation TAS 8089075
GO:0006913 nucleocytoplasmic transport IEA --
GO:0006954 inflammatory response IEA --
genes like me logo Genes that share ontologies with CAMK4: view

Drugs & Compounds for CAMK4 Gene

(13) Drugs for CAMK4 Gene - From: NovoSeek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Nitric Oxide Approved Pharma 540
3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one Experimental Pharma Target 0
5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE Experimental Pharma Target 0
cyclic amp Experimental Pharma 0

(4) Additional Compounds for CAMK4 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
IONOMYCIN
Retinoid
Syntide-2
genes like me logo Genes that share compounds with CAMK4: view

Transcripts for CAMK4 Gene

Unigene Clusters for CAMK4 Gene

Calcium/calmodulin-dependent protein kinase IV:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAMK4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAMK4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c
SP1: - -
SP2:
SP3:

Relevant External Links for CAMK4 Gene

GeneLoc Exon Structure for
CAMK4
ECgene alternative splicing isoforms for
CAMK4

Expression for CAMK4 Gene

mRNA expression in normal human tissues for CAMK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAMK4 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x12.4), Brain - Cerebellum (x11.3), Brain - Nucleus accumbens (basal ganglia) (x5.0), and Brain - Putamen (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for CAMK4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (34.8), Lymph node (14.7), and Frontal cortex (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAMK4 Gene



SOURCE GeneReport for Unigene cluster for CAMK4 Gene Hs.591269

mRNA Expression by UniProt/SwissProt for CAMK4 Gene

Q16566-KCC4_HUMAN
Tissue specificity: Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue.
genes like me logo Genes that share expression patterns with CAMK4: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for CAMK4 Gene

Orthologs for CAMK4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CAMK4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CAMK4 35
  • 85.71 (n)
  • 83.12 (a)
CAMK4 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAMK4 35
  • 90.17 (n)
  • 90.17 (a)
CAMK4 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Camk4 35
  • 83.26 (n)
  • 81.97 (a)
Camk4 16
Camk4 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CAMK4 35
  • 99.58 (n)
  • 99.79 (a)
CAMK4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Camk4 35
  • 82.51 (n)
  • 83.01 (a)
oppossum
(Monodelphis domestica)
Mammalia CAMK4 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAMK4 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves CAMK4 35
  • 76.61 (n)
  • 80.39 (a)
CAMK4 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAMK4 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia camk4 35
  • 76.29 (n)
  • 81.1 (a)
African clawed frog
(Xenopus laevis)
Amphibia camk4-A 35
zebrafish
(Danio rerio)
Actinopterygii camk4 35
  • 72.07 (n)
  • 79.12 (a)
camk4 36
  • 81 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CaMKI 36
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cmk-1 36
  • 42 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMK1 36
  • 29 (a)
ManyToMany
CMK2 36
  • 26 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9956 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
OneToOne
Species with no ortholog for CAMK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAMK4 Gene

ENSEMBL:
Gene Tree for CAMK4 (if available)
TreeFam:
Gene Tree for CAMK4 (if available)

Paralogs for CAMK4 Gene

genes like me logo Genes that share paralogs with CAMK4: view

Variants for CAMK4 Gene

Sequence variations from dbSNP and Humsavar for CAMK4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_040604 A lung adenocarcinoma sample
VAR_040605 -
VAR_040606 -
VAR_040607 A lung large cell carcinoma sample

Structural Variations from Database of Genomic Variants (DGV) for CAMK4 Gene

Variant ID Type Subtype PubMed ID
nsv882709 CNV Loss 21882294
esv29054 CNV Loss 19812545
dgv1038e199 CNV Deletion 23128226
esv271918 CNV Insertion 20981092
nsv823173 CNV Loss 20364138
esv269264 CNV Insertion 20981092
esv274515 CNV Insertion 20981092
nsv518727 CNV Gain 19592680
esv2647908 CNV Deletion 19546169
esv2313843 CNV Deletion 18987734
esv4209 CNV Deletion 18987735
esv8952 CNV Loss 19470904
esv2730592 CNV Deletion 23290073
esv1341497 CNV Deletion 17803354
nsv328700 CNV Loss 16902084
nsv830449 CNV Gain+Loss 17160897
nsv823174 CNV Loss 20364138

Variation tolerance for CAMK4 Gene

Residual Variation Intolerance Score: 28.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.89; 48.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAMK4 Gene

HapMap Linkage Disequilibrium report
CAMK4
Human Gene Mutation Database (HGMD)
CAMK4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMK4 Gene

Disorders for CAMK4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CAMK4 Gene - From: NovoSeek

Disorder Aliases PubMed IDs
cerebral hypoxia
  • brain hypoxia
- elite association
Search CAMK4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CAMK4

Genetic Association Database (GAD)
CAMK4
Human Genome Epidemiology (HuGE) Navigator
CAMK4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAMK4
genes like me logo Genes that share disorders with CAMK4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAMK4 Gene

Publications for CAMK4 Gene

  1. PLC/CAMK IV-NF-kappaB involved in the receptor for advanced glycation end products mediated signaling pathway in human endothelial cells. (PMID: 20171262) You J. … Lin J.Y. (Mol. Cell. Endocrinol. 2010) 23 67
  2. Thyroid hormone regulation of gene expression in the developing rat fetal cerebral cortex: prominent role of the Ca2+/calmodulin-dependent protein kinase IV pathway. (PMID: 20056827) Morte B. … Bernal J. (Endocrinology 2010) 23 67
  3. The heterogeneous nuclear ribonucleoprotein L is an essential component in the Ca2+/calmodulin-dependent protein kinase IV-regulated alternative splicing through cytidine-adenosine repeats. (PMID: 19017650) Yu J. … Xie J. (J. Biol. Chem. 2009) 23 67
  4. Neuronal cell depolarization induces intragenic chromatin modifications affecting NCAM alternative splicing. (PMID: 19251664) Schor I.E. … Kornblihtt A.R. (Proc. Natl. Acad. Sci. U.S.A. 2009) 23 67
  5. In vivo selection of kinase-responsive RNA elements controlling alternative splicing. (PMID: 19386606) Li H. … Xie J. (J. Biol. Chem. 2009) 23 67

Products for CAMK4 Gene

Sources for CAMK4 Gene

Back to Top

Content