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CAMK4 Gene

protein-coding GIFtS: 62

GC05P110587

calcium/calmodulin-dependent protein kinase IV
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CaMK-GR ^¹, ²
EC 2.7.11.17 ^³
MGC36771 ^²

Descriptions
CAM kinase IV ^²
CAM kinase- GR ^²
CAM kinase-GR ^³
CaMK IV ^³
brain Ca(2+)-calmodulin-dependent protein kinase type IV ^²
brain Ca++-calmodulin-dependent protein kinase type IV ^²
calcium/calmodulin-dependent protein kinase IV ^²
calcium/calmodulin-dependent protein kinase type IV catalytic chain ^²

External Ids
HGNC: 1464¹
Entrez Gene: 814²
UniProtKB: Q16566³
Ensembl: ENSG00000152495⁷

Search outside databases for aliases for CAMK4 gene

Previous GC identifers: GC05P110183 GC05P111005 GC05P110590 GC05P110636

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CAMK4:

The product of this gene belongs to the serine/threonine protein kinase family, and to the

Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional

serine/threonine protein kinase with limited tissue distribution, that has been implicated in

transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq]

UniProtKB/Swiss-Prot: KCC4_HUMAN, Q16566

Function: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered

signaling cascade. May be involved in transcriptional regulation. May be involved in regulation of

microtubule dynamics. In vitro, phosphorylates CREB1, CREBBP, PRM2, MEF2A, MEF2D and STMN1/OP18.

May be involved in spermatogenesis. May play a role in the consolidation/retention of

hippocampus-dependent long-term memory (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CAMK4 gene

Entrez Gene cytogenetic band: 5q21.3 Ensembl cytogenetic band: 5q22.1 HGNC cytogenetic band: 5q21-q23

CAMK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P110587: (about GC identifiers)

Start:	110,587,981 bp from pter
End:	110,848,648 bp from pter
Size:	260,668 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000005.8 NT_034772.5

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: KCC4_HUMAN, Q16566 (See protein sequence)

Recommended Name: Calcium/calmodulin-dependent protein kinase type IV

Size: 473 amino acids; 51926 Da

Subunit: Monomer (By similarity). Interacts with serine/threonine protein phosphatase 2A catalytic

subunit, PPP2CA or PPP2CB. The interaction with PP2CA or PP2CB is mutually exclusive with binding

to Ca(2+)/calmodulin

Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Note=Substantial

localization in certain neuronal nuclei. In spermatids associated with chromatin and nuclear

matrix (By similarity)

PDB structures from and Proteopedia :

2W4O (3D)

Post-translational modifications:

Autophosphorylated and phosphorylated by CAMKK1 and CAMKK2 (By similarity). Dephosphorylated by

serine/threonine protein phosphatase 2A, probably on Thr-200¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001735.1

ENSEMBL proteins:

ENSP00000282356

Human Recombinant Proteins

	Invitrogen human recombinant proteins for CAMK4
	Millipore Purified and/or Recombinant CAMK4 Protein
	Sigma-Aldrich Proteins for CAMK4
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for CAMK4
	Recombinant Proteins from Abcam (CAMKIV)
	Human Recombinant Proteins from Abnova (CAMK4)

OriGene Purified Recombinant Human Protein: CAMK4

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

About this table

Antibodies for CAMK4:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for CAMK4
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for CAMK4
	Antibodies from Abcam (CAMKIV), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CAMK4)
	Novus Biologicals Antibodies for CAMK4

Assays for CAMK4:

	Invitrogen Assays for CAMK4
	Millipore Kits and Assays for the Analysis of CAMK4
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q16566

ProtoNet protein and cluster: Q16566

UniProtKB/Swiss-Prot: KCC4_HUMAN, Q16566

Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK

subfamily

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CAMK4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CAMK4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001744

Applied Biosystems Silencer® siRNAs for CAMK4

Sigma-Aldrich siRNA and siRNA Panels for CAMK4

Sigma-Aldrich shRNA Panels and shRNA for CAMK4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CAMK4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001744
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001744
untagged cDNA clones in CMV expression vector (see all 2): NM_001744

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001744

UniProtKB/Swiss-Prot: KCC4_HUMAN, Q16566

Function: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered

signaling cascade. May be involved in transcriptional regulation. May be involved in regulation of

microtubule dynamics. In vitro, phosphorylates CREB1, CREBBP, PRM2, MEF2A, MEF2D and STMN1/OP18.

May be involved in spermatogenesis. May play a role in the consolidation/retention of

hippocampus-dependent long-term memory (By similarity)

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme regulation: Activated by Ca(2+)/calmodulin. Binding of calmodulin may releave intrasteric

autoinhibition. Must be phosphorylated to be maximally active. Phosphorylated by CAMKK1 or CAMKK2.

Autophosphorylation of the N-terminus is required for full activation. In part, activity is

independent on Ca(2+)/calmodulin and autophosphorylation of Ser-336 allows to switch to a

Ca(2+)/calmodulin-independent state (By similarity). Probably inactivated by serine/threonine

protein phosphatase 2A

Enzyme Number (IUBMB): EC 2.7.11.17

Genatlas biochemistry entry for CAMK4:

protein kinase,type IV,calcium/calmodulin dependent,brain

13 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Camk4):

behavior/neurological	endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism
immune system	life span-post-weaning/aging	nervous system	no phenotypic analysis	normal
reproductive system	skeleton	touch/vibrissae

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004683	calmodulin-dependent protein kinase activity	IEA	--
GO:0005509	calcium ion binding	IEA	--
GO:0005516	calmodulin binding	IEA	--
GO:0005524	ATP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/29 Sigma-Aldrich "Your Favorite Gene" Pathways for CAMK4 (Your Favorite Gene powered by Ingenuity) (see all 29 )

Xenobiotic Metabolism Signaling
cAMP-mediated Signaling
CREB Signaling in Neurons
G-Protein Coupled Receptor Signaling
Nitric Oxide Signaling in the Cardiovascular System

GeneDecks CAMK4 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for CAMK4

5/19 Interacting proteins for CAMK4 (ENSP00000282356³) via UniProtKB, MINT, and/or STRING (see all 19 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CREB1	ENSP00000236996³	STRING (score=.998)
CALM3	ENSP00000291295³	STRING (score=.992)
SRF	ENSP00000265354³	STRING (score=.985)
HDAC4	ENSP00000264606³	STRING (score=.976)
CABIN1	ENSP00000263119³	STRING (score=.969)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein amino acid phosphorylation	TAS	8089075
GO:0007165	signal transduction	TAS	8089075

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CAMK4
10 Novoseek chemical compound relationships for CAMK4 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
syntide-2	86.99	1	15262326 (1)
calcium	51.87	33	1645731 (3), 10191497 (2), 11443132 (2), 14701808 (2) (see all 22)
threonine	44.62	4	10932193 (1), 15143065 (1), 15262326 (1)
cyclic amp	39.19	2	17428448 (1), 12234621 (1)
ionomycin	34.82	1	7925472 (1)
atp	28.11	1	8194751 (1)
potassium	0.00	1	11149901 (1)
nitric oxide	0.00	4	16709637 (1), 17091402 (1), 12457729 (1)
magnesium	0.00	1	8586621 (1)
tyrosine	0.00	1	8292050 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CAMK4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CAMK4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001744

Sigma-Aldrich siRNA and siRNA Panels for CAMK4

Sigma-Aldrich shRNA Panels and shRNA for CAMK4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001744

REFSEQ mRNAs for CAMK4 gene:

NM_001744.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001744

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001744
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001744
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001744

Additional cDNA sequence:

AK311662.1 AK312840.1 BC016695.1 BC025687.1 CR615443.1 CR622299.1 D30742.1 L17000.1

L24959.1

9 DOTS entries:

DT.408507 DT.311969 DT.307413 DT.97771009 DT.120813754 DT.120813794 DT.95161510 DT.120813801

DT.99991905

24/39 AceView cDNA sequences (see all 39 ):

AL134969 BP379092 AA361421 BM986829 L24959 CR622299 AI627334 D30742

CB141413 CR615443 AL119808 AA455227 CD558096 BC025687 BX376712 NM_001744

CD557572 BX506878 L17000 BX374853 BI561151 BC016695 BX348258 AL833368

highest scoring ESTs for CAMK4:

D30742 AA465605 AI627334 AI636568 AI656423 AL582172 AW025962 AW968536 AW968709 BC016695

Unigene Cluster for CAMK4:

Calcium/calmodulin-dependent protein kinase IV

Hs.591269 [show with all ESTs]

Unigene Representative Sequence: NM_001744

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for CAMK4

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5a	·	5b	·	5c
SP1:					-		-
SP2:
SP3:

About this scheme

ECgene alternative splicing isoforms for CAMK4

1 Ensembl transcript including schematic representation:

ENST00000282356

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CAMK4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CAMK4

¹ / ² / ³

5 probe-sets matching CAMK4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1422_g_at²^{, 3}	U95-A	1	1.00	1.00	0.90	1.47	D30742	1.00	1.00	1.00	1
33514_at²^{, 3}	U95-A	1	1.00	1.00	0.97	1.35	D30742	1.00	1.00	1.00	1
1421_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.79	D30742	1.00	1.00	1.00	1
210349_at²^{, 3}	U133-A	1	1.00	1.00	--	--	L24959	0.80	1.00	0.91	1
210349_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CAMK4 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAGCCATATG

SOURCE GeneReport for Unigene cluster: Hs.591269
Expression variation in blood from EXPOLDB for CAMK4
UniProtKB/Swiss-Prot: KCC4_HUMAN, Q16566
Tissue specificity: Expressed in epithelial ovarian cancer tissue

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CAMK4 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	CAMK4¹	--	calcium/calmodulin-dependent protein kinase IV	99.51(n) 99.79(a)	461992 XM_517873.2 XP_517873.2
rat (Rattus norvegicus)	Camk4¹	--	calcium/calmodulin-dependent protein kinase IV	83.01(n) 83.44(a)	25050 NM_012727.2 NP_036859.2
mouse (Mus musculus)	Camk4^{1, 5}	18 (12.00 cM)⁵	calcium/calmodulin-dependent protein kinase IV^{1, 5}	83.69(n)¹ 82.19(a)¹	12326¹ NM_009793.2¹ NP_033923.1¹ AA119683⁵ AI644556⁵ (see all 23)
chicken (Gallus gallus)	CAMK4¹	--	calcium/calmodulin-dependent protein kinase IV	76.62(n) 80(a)	723973 NM_001034813.1 NP_001029985.1
zebrafish (Danio rerio)	camk4¹	--	calcium/calmodulin-dependent protein kinase IV	72.71(n) 81.04(a)	550270 NM_001017607.1 NP_001017607.1

About this table Species with no ortholog for CAMK4

ENSEMBL Gene Tree for CAMK4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CAMK4 gene

PSKH2² PSKH1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1627 NCBI SNPs in CAMK4 are shown (see all 1627 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 501)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1457114^1,2	A,C,F,H	110586781(+)	`GTTGGA/GGGAAA`	1	--	ng5¹		4		EU EA WA	420
--	rs2162892^1,2	A,C,F,H	110586391(-)	`AATACT/CACAGG`	1	--	ng5¹		4		EU EA WA	420
	rs7714962^1,2	A,C,F	110587453(+)	`TGGTGC/TTAGGT`	1	--	ng5¹		2		MN EA	356
	rs35548075^1,2	C,F	110810355(+)	`CCCCAG/AATGCA`	1	N/D	mis¹		4		EU EA WA	420
	rs1042101^1,2	H	110847981(+)	`GGAGGC/TAGCAG`	1	A/V	mis¹		8		NA EA MN EU WA	842
	rs13157105^1,2	H	110848418(+)	`GGATTT/CCTTCA`	1	--	ut3¹		4		EU EA WA	408
--	rs17133293^1,2	F	110848776(+)	`GTTCCA/GTTCTT`	1	--	ng3¹		3		NA	142
	rs13174852^1,2	H	110848515(+)	`TTTTTA/TTCATT`	1	--	ut3¹		2		EU WA	204
--	rs10059307^1,2	A	110848765(+)	`ACTCAC/TGCTGA`	1	--	ng3¹ ese³		0	--	--	--	--
--	rs10069052^1,2	A	110849009(+)	`GAAAAA/TTCTAT`	1	--	ng3¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for CAMK4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 114080

1 Novoseek disease relationship for CAMK4 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cerebral hypoxia	53.26	1	15262326 (1)

About this table

Human Genome Epidemiology Navigator: CAMK4 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/111 PubMed articles for CAMK4 gene (see all 111 ):

A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1. (PubMed id 8107230)^{1, 3, 4} Mosialos G....Chatila T.A. (1994)
Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex. (PubMed id 15143065)^{1, 3, 4} Anderson K.A.... Means A.R. (2004)
The cDNA sequence and characterization of the Ca2+/calmodulin- dependent protein kinase-Gr from human brain and thymus. (PubMed id 8194751)^{1, 3, 4} Bland M.M.... Ohmstede C.A. (1994)
cDNA cloning and expression of human calmodulin-dependent protein kinase IV. (PubMed id 8089075)^{1, 3, 4} Kitani T.... Fujisawa H. (1994)
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)^{3, 4} Wissing J.... Daub H. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Ca(2+)/calmodulin-dependent protein kinase IV expression in epithelial ovarian cancer. (PubMed id 12065094)^{3, 4} Takai N.... Miyakawa I. (2002)
Ca(2+)-dependent gene expression mediated by MEF2 transcription factors. (PubMed id 10617605)^{3, 4} Blaeser F.... Chatila T.A. (2000)
Regulation of microtubule dynamics by Ca2+/calmodulin-dependent kinase IV/Gr-dependent phosphorylation of oncoprotein 18. (PubMed id 9154845)^{3, 4} Melander Gradin H....Gullberg M. (1997)
A unique phosphorylation-dependent mechanism for the activation of Ca2+/calmodulin-dependent protein kinase type IV/GR. (PubMed id 8702940)^{3, 4} Chatila T.... Means A.R. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 814	HGNC: 1464	AceView: CAMK4	Ensembl:ENSG00000152495	euGenes: HUgn814
ECgene: CAMK4	H-InvDB: CAMK4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CAMK4	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for CAMK4
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CAMK4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CAMK4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CAMK4		Antibodies for CAMK4
	Explore super-pooled esiRNAs		Proteins for CAMK4
	Lentivirus-delivered shRNAs for CAMK4		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CAMK4)
	Antibodies (CAMK4)
	Chimera RNAi (CAMK4)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for CAMK4

	Recombinant Proteins (CAMKIV)
	Antibodies (CAMKIV)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for CAMK4

	Proteins for CAMK4
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CAMK4

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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CAMK4 Gene at Home site.
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CAMK4 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for CAMK4

Summaries
for CAMK4

Genomic Location
for CAMK4

Proteins
for CAMK4

Protein Domains/
Families
for CAMK4

Gene Function
for CAMK4

Pathways & Interactions
for CAMK4

Drugs & Compounds
for CAMK4

Transcripts
for CAMK4

Expression
for CAMK4

Orthologs
for CAMK4

Paralogs
for CAMK4

SNPs/Variants
for CAMK4

Disorders & Mutations
for CAMK4

Medical News
for CAMK4

Publications
for CAMK4

Search for CAMK4

Genome Databases showing CAMK4

Other Databases showing CAMK4

Specialized Databases showing CAMK4

Licensable Technologies
for CAMK4

Services
for CAMK4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CAMK4 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor CAMK4

Summariesfor CAMK4

Genomic Locationfor CAMK4

Proteinsfor CAMK4

Protein Domains/Familiesfor CAMK4

Gene Functionfor CAMK4

Pathways & Interactionsfor CAMK4

Drugs & Compoundsfor CAMK4

Transcriptsfor CAMK4

Expression for CAMK4

Orthologsfor CAMK4

Paralogsfor CAMK4

SNPs/Variantsfor CAMK4

Disorders & Mutationsfor CAMK4

Medical Newsfor CAMK4

Publicationsfor CAMK4

Search for CAMK4

Genome Databases showing CAMK4

Other Databases showing CAMK4

Specialized Databases showing CAMK4

Licensable Technologiesfor CAMK4

Servicesfor CAMK4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CAMK4

Summaries
for CAMK4

Genomic Location
for CAMK4

Proteins
for CAMK4

Protein Domains/
Families
for CAMK4

Gene Function
for CAMK4

Pathways & Interactions
for CAMK4

Drugs & Compounds
for CAMK4

Transcripts
for CAMK4

Expression
for CAMK4

Orthologs
for CAMK4

Paralogs
for CAMK4

SNPs/Variants
for CAMK4

Disorders & Mutations
for CAMK4

Medical News
for CAMK4

Publications
for CAMK4

Licensable Technologies
for CAMK4

Services
for CAMK4