Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CAMK2N2 Gene

protein-coding   GIFtS: 42
GCID: GC03M183977

Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor...

  See CAMK2N2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor 21 2
CaM-KII Inhibitory Protein2 3
CAMKIIN2 5
CAM-KIIN2
CaM-KIIN3

External Ids:    HGNC: 241971   Entrez Gene: 940322   Ensembl: ENSG000001638887   OMIM: 6087215   UniProtKB: Q96S953   

Export aliases for CAMK2N2 gene to outside databases

Previous GC identifers: GC03M185461 GC03M181384


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CAMK2N2 Gene:
This gene encodes a protein that is highly similar to the rat CaM-KII inhibitory protein, an inhibitor of
calcium/calmodulin-dependent protein kinase II (CAMKII). CAMKII regulates numerous physiological functions,
including neuronal synaptic plasticity through the phosphorylation of
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate (AMPA) receptors. Studies of the similar
protein in rat suggest that this protein may function as a negative regulator of CaM-KII and may act to inhibit
the phosphorylation of AMPA receptors. (provided by RefSeq, Jul 2008)

GeneCards Summary for CAMK2N2 Gene:
CAMK2N2 (calcium/calmodulin-dependent protein kinase II inhibitor 2) is a protein-coding gene. Diseases associated with CAMK2N2 include colorectal adenocarcinoma. GO annotations related to this gene include calcium-dependent protein kinase inhibitor activity and protein kinase binding. An important paralog of this gene is CAMK2N1.

UniProtKB/Swiss-Prot: CK2N2_HUMAN, Q96S95
Function: Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May
play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells.
Traps Ca(2+)/calmodulin on CAMK2




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CAMK2N2 gene promoter:
         E2F-4   E2F-3a   E2F-5   Pax-5   E2F-2   NF-kappaB   E2F   E2F-1   STAT3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCAMK2N2 promoter sequence
   Search Chromatin IP Primers for CAMK2N2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CAMK2N2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27.1   Ensembl cytogenetic band:  3q27.1   HGNC cytogenetic band: 3q27.1

CAMK2N2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAMK2N2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M183977:  view genomic region     (about GC identifiers)

Start:
183,977,001 bp from pter      End:
183,979,251 bp from pter
Size:
2,251 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CK2N2_HUMAN, Q96S95 (See protein sequence)
Recommended Name: Calcium/calmodulin-dependent protein kinase II inhibitor 2  
Size: 79 amino acids; 8658 Da
Subunit: Interacts with CAMK2A and CAMK2B in the presence of Ca(2+)/calmodulin or after autophosphorylation (By
similarity)

Explore the universe of human proteins at neXtProt for CAMK2N2: NX_Q96S95

Explore proteomics data for CAMK2N2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CAMK2N2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_150284.1  
    ENSEMBL proteins: 
     ENSP00000296238  

    CAMK2N2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CAMK2N2
    OriGene Protein Over-expression Lysate for CAMK2N2
    OriGene MassSpec for CAMK2N2
    OriGene Custom Protein Services for CAMK2N2
    GenScript Custom Purified and Recombinant Proteins Services for CAMK2N2
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CAMK2N2

     
    Search eBioscience for Proteins for CAMK2N2 

    CAMK2N2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CAMK2N2
    OriGene Custom Antibody Services for CAMK2N2
    Novus Biologicals CAMK2N2 Antibody
    Search for Antibodies for CAMK2N2 at Abcam
    Cloud-Clone Corp. Antibodies for CAMK2N2
    Search ThermoFisher Antibodies for CAMK2N2
    LSBio Antibodies in human, mouse, rat for CAMK2N2

    CAMK2N2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CAMK2N2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CAMK2N2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CAMK2N2
    Cloud-Clone Corp. CLIAs for CAMK2N2
    Search eBioscience for ELISAs for CAMK2N2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR026779 Camk2n

    Graphical View of Domain Structure for InterPro Entry Q96S95

    ProtoNet protein and cluster: Q96S95

    UniProtKB/Swiss-Prot: CK2N2_HUMAN, Q96S95
    Domain: The inhibitory domain blocks CAMK2 binding to GRIN2B (By similarity)
    Similarity: Belongs to the CAMK2N family


    Find genes that share domains with CAMK2N2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CK2N2_HUMAN, Q96S95
    Function: Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May
    play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells.
    Traps Ca(2+)/calmodulin on CAMK2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008427calcium-dependent protein kinase inhibitor activity IEA--
    GO:0019901protein kinase binding IEA--
         
    Find genes that share ontologies with CAMK2N2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CAMK2N2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CAMK2N2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAMK2N2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAMK2N2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CAMK2N2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CAMK2N2 (see all 43):
    hsa-miR-106a hsa-miR-346 hsa-miR-30d hsa-miR-486-3p hsa-miR-519a hsa-miR-30a hsa-miR-298 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidCAMK2N2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CAMK2N2
    Predesigned siRNA for gene silencing in human, mouse, rat CAMK2N2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CAMK2N2

    Clone
    Products:
         
    OriGene clones in human, mouse for CAMK2N2 (see all 5)
    OriGene ORF clones in mouse, rat for CAMK2N2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CAMK2N2 (NM_033259)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAMK2N2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMK2N2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CAMK2N2
    Browse ESI BIO Cell Lines and PureStem Progenitors for CAMK2N2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMK2N2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CK2N2_HUMAN, Q96S95: Nucleus. Cytoplasm, cytosol. Note=Excluded from nucleus when coexpressed with activated
    CAMK2 (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol IEA--

    Find genes that share ontologies with CAMK2N2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CAMK2N2
    Interactions:

        GeneGlobe Interaction Network for CAMK2N2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for CAMK2N2 (Q96S953 ENSP000002962384) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARHGAP32A7KAX93, ENSP000003105614STRING: ENSP00000310561 I2D: score=1 
    CAMK2BQ135543, ENSP000002586824I2D: score=1 STRING: ENSP00000258682
    CAMK2AENSP000003814124STRING: ENSP00000381412
    --A8K1613I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CAMK2N2 (CK2N2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CAMK2N2 gene: 
    NM_033259.2  

    Unigene Cluster for CAMK2N2:

    Calcium/calmodulin-dependent protein kinase II inhibitor 2
    Hs.585003  [show with all ESTs]
    Unigene Representative Sequence: NM_033259
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000296238(uc003fnj.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CAMK2N2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CAMK2N2 (see all 43):
    hsa-miR-106a hsa-miR-346 hsa-miR-30d hsa-miR-486-3p hsa-miR-519a hsa-miR-30a hsa-miR-298 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidCAMK2N2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CAMK2N2
    Predesigned siRNA for gene silencing in human, mouse, rat CAMK2N2
    Clone
    Products:
         
    OriGene clones in human, mouse for CAMK2N2 (see all 5)
    OriGene ORF clones in mouse, rat for CAMK2N2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CAMK2N2 (NM_033259)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAMK2N2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMK2N2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CAMK2N2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CAMK2N2
      QuantiTect SYBR Green Assays in human, mouse, rat CAMK2N2
      QuantiFast Probe-based Assays in human, mouse, rat CAMK2N2

    Additional mRNA sequence: 

    AY037149.1 BC105077.1 BC105079.1 

    2 DOTS entries:

    DT.426551  DT.310960 

    6 AceView cDNA sequences:

    NM_033259 AY037149 BX280361 BM966986 AI363920 BM128638 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CAMK2N2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCAGTCTGC
    CAMK2N2 Expression
    About this image

    CAMK2N2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CAMK2N2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.585003

    UniProtKB/Swiss-Prot: CK2N2_HUMAN, Q96S95
    Tissue specificity: Expressed in cell lines including hemopoietic cell lines and some tumor cell lines. Highly
    Expressed in stimulated dendritic cell (DC) and weakly expressed in unstimulated mature and immature DC. Highly
    expressed in kidney, liver, in cell lines HeLaS3, lymphoblastic leukemia MOLT-4, and Burkitt's lymphoma Raji.
    Moderately expressed in heart, skeletal muscle, placenta, and chronic myelogenous leukemia K-562 cells. Weakly
    expressed in small intestine, colorectal adenocarcinoma SW480, and lung carcinoma A-549 cells

        Custom PCR Arrays for CAMK2N2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CAMK2N2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CAMK2N2
    QuantiTect SYBR Green Assays in human, mouse, rat CAMK2N2
    QuantiFast Probe-based Assays in human, mouse, rat CAMK2N2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMK2N2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for CAMK2N2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Camk2n21 , 5 calcium/calmodulin-dependent protein kinase II inhibitor more1, 5 95.36(n)1
    98.73(a)1
      16 (12.48 cM)5
    730471  NM_028420.21  NP_082696.11 
     206192155 
    chicken
    (Gallus gallus)
    Aves LOC1017473801 vegetative cell wall protein gp1-like 84.52(n)
    76.79(a)
      101747380  XM_004943600.1  XP_004943657.1 
    lizard
    (Anolis carolinensis)
    Reptilia CAMK2N26
    calcium/calmodulin-dependent protein kinase II inh...
    78(a)
    1 ↔ 1
    GL343245.1(513928-517306)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia camk2n21 calcium/calmodulin-dependent protein kinase II inhibitor more 75.11(n)
    75.95(a)
      780061  NM_001171604.1  NP_001165075.1 
    zebrafish
    (Danio rerio)
    Actinopterygii camk2n1a1 calcium/calmodulin-dependent protein kinase II inhibitor more 72.15(n)
    73.42(a)
      553607  NM_001145089.2  NP_001138561.1 


    ENSEMBL Gene Tree for CAMK2N2 (if available)
    TreeFam Gene Tree for CAMK2N2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CAMK2N2 gene
    CAMK2N12  
    1 SIMAP similar gene for CAMK2N2 using alignment to 1 protein entry:     CK2N2_HUMAN:
    CAMK2N1

    Find genes that share paralogs with CAMK2N2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus
    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CAMK2N2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv4146CNV Insertion18451855
    nsv878060CNV Loss21882294
    nsv878062CNV Loss21882294
    dgv5354n71CNV Loss21882294
    nsv829812CNV Loss17160897
    nsv528639CNV Loss19592680
    nsv878057CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CAMK2N2
    DNA2.0 Custom Variant and Variant Library Synthesis for CAMK2N2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608721    OMIM disorders: --

    1 disease for CAMK2N2:    
    About MalaCards
    colorectal adenocarcinoma


    Find genes that share disorders with CAMK2N2           About GenesLikeMe


    Export disorders for CAMK2N2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CAMK2N2 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with CAMK2N2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel calcium/calmodulin- dependent protein kinase II inhibitor from human dendritic cells. (PubMed id 11444830)1, 2, 3, 9 Zhang J.... Cao X. (Biochem. Biophys. Res. Commun. 2001)
    2. Characterization of a calmodulin kinase II inhibitor protein in brain. (PubMed id 9724800)1, 3 Chang B.H....Soderling T.R. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    3. Endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest and apoptosis through down-regulation of the phosphatidylinositide 3-kinase/Akt/HDM2 pathway. (PubMed id 19586909)1, 9 Ma S....Cao X. (J. Biol. Chem. 2009)
    4. Genome wide array analysis indicates that an amyotrophic lateral sclerosis mutation of FUS causes an early increase of CAMK2N2 in vitro. (PubMed id 23545117)1 Convertini P....Stamm S. (Biochim. Biophys. Acta 2013)
    5. Downregulation of extracellular signal-regulated kinase 1/2 activity by calmodulin KII modulates p21Cip1 levels and survival of immortalized lymphocytes from Alzheimer's disease patients. (PubMed id 23153928)1 Esteras N....MartA-n-Requero A. (Neurobiol. Aging 2013)
    6. A mega-analysis of genome-wide association studies for major depressive disorder. (PubMed id 22472876)1  ....Sullivan P.F. (Mol. Psychiatry 2013)
    7. Biochemical and computational analysis of LNX1 interacting proteins. (PubMed id 22087225)1 Wolting C.D....McGlade C.J. (PLoS ONE 2011)
    8. Differential regulation of CaMKII inhibitor beta protein expression after exposure to a novel context and during contextual fear memory formation. (PubMed id 20487031)1 RadwaA8ska K....Giese K.P. (Genes Brain Behav. 2010)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling. (PubMed id 12531901)1 Okabe T.... Akiyama T. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 94032 HGNC: 24197 AceView: CAM-KIIN Ensembl:ENSG00000163888 euGenes: HUgn94032
    ECgene: CAMK2N2 H-InvDB: CAMK2N2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CAMK2N2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CAMK2N2 gene:
    Search GeneIP for patents involving CAMK2N2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CAMK2N2   OriGene RNAi products in human, mouse, rat for CAMK2N2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for CAMK2N2  
     OriGene MassSpec something-or-other for CAMK2N2   OriGene clones in human, mouse for CAMK2N2  
     OriGene qSTAR qPCR primer pairs in human, mouse for CAMK2N2   OriGene Purified Protein for CAMK2N2  
     OriGene ORF clones in mouse, rat for CAMK2N2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CAMK2N2   OriGene Custom Protein Services for CAMK2N2  

     
     
     Block miRNA regulation of human, mouse, rat CAMK2N2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CAMK2N2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CAMK2N2 Predesigned siRNA for gene silencing in human, mouse, rat CAMK2N2
     QuantiFast Probe-based Assays in human, mouse, rat CAMK2N2 QuantiTect SYBR Green Assays in human, mouse, rat CAMK2N2
     Custom PCR Arrays for CAMK2N2 Search Chromatin IP Primers for CAMK2N2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CAMK2N2  GeneGlobe Interaction Network for CAMK2N2
     Regulatory tfbs in CAMK2N2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CAMK2N2 GenScript cDNA clones with any tag delivered in your preferred vector for CAMK2N2
     GenScript Custom Assay Services for CAMK2N2 GenScript Custom overexpressing Cell Line Services for CAMK2N2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CAMK2N2 (CK2N2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CAMK2N2 antibodies
     Search for Antibodies for CAMK2N2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CAMK2N2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CAMK2N2
     Antibodies for CAMK2N2
     ELISAs for CAMK2N2
     CLIAs for CAMK2N2



     Browse ESI BIO Cell Lines and PureStem Progenitors for CAMK2N2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMK2N2
     SwitchGear 3'UTR luciferase reporter plasmids for CAMK2N2
     SwitchGear Promoter luciferase reporter plasmids for CAMK2N2
     Search ThermoFisher Antibodies for CAMK2N2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMK2N2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CAMK2N2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CAMK2N2
     LSBio Antibodies in human, mouse, rat for CAMK2N2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for CAMK2N2
      Search eBioscience for proteins for CAMK2N2
      Search eBioscience for elisas for CAMK2N2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CAMK2N2 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4