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Aliases for CAMK2N2 Gene

Aliases for CAMK2N2 Gene

  • Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor 2 2 3
  • CaM-KII Inhibitory Protein 3 4
  • CAM-KIIN 3 4
  • CAMKIIN 3 6

External Ids for CAMK2N2 Gene

Summaries for CAMK2N2 Gene

Entrez Gene Summary for CAMK2N2 Gene

  • This gene encodes a protein that is highly similar to the rat CaM-KII inhibitory protein, an inhibitor of calcium/calmodulin-dependent protein kinase II (CAMKII). CAMKII regulates numerous physiological functions, including neuronal synaptic plasticity through the phosphorylation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate (AMPA) receptors. Studies of the similar protein in rat suggest that this protein may function as a negative regulator of CaM-KII and may act to inhibit the phosphorylation of AMPA receptors. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAMK2N2 Gene

CAMK2N2 (Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor 2) is a Protein Coding gene. Diseases associated with CAMK2N2 include colorectal adenocarcinoma. GO annotations related to this gene include protein kinase binding and calcium-dependent protein kinase inhibitor activity. An important paralog of this gene is CAMK2N1.

UniProtKB/Swiss-Prot for CAMK2N2 Gene

  • Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells. Traps Ca(2+)/calmodulin on CAMK2.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMK2N2 Gene

Genomics for CAMK2N2 Gene

Genomic Location for CAMK2N2 Gene

184,259,213 bp from pter
184,261,463 bp from pter
2,251 bases
Minus strand

Genomic View for CAMK2N2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAMK2N2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMK2N2 Gene

Regulatory Elements for CAMK2N2 Gene

Proteins for CAMK2N2 Gene

  • Protein details for CAMK2N2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcium/calmodulin-dependent protein kinase II inhibitor 2
    Protein Accession:
    Secondary Accessions:

    Protein attributes for CAMK2N2 Gene

    79 amino acids
    Molecular mass:
    8658 Da
    Quaternary structure:
    • Interacts with CAMK2A and CAMK2B in the presence of Ca(2+)/calmodulin or after autophosphorylation.

neXtProt entry for CAMK2N2 Gene

Proteomics data for CAMK2N2 Gene at MOPED

Post-translational modifications for CAMK2N2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAMK2N2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CAMK2N2 Gene

Domains for CAMK2N2 Gene

Protein Domains for CAMK2N2 Gene



  • The inhibitory domain blocks CAMK2 binding to GRIN2B.:
    • Q96S95
  • Belongs to the CAMK2N family.:
    • Q96S95
genes like me logo Genes that share domains with CAMK2N2: view

No data available for Gene Families for CAMK2N2 Gene

Function for CAMK2N2 Gene

Molecular function for CAMK2N2 Gene

UniProtKB/Swiss-Prot Function: Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells. Traps Ca(2+)/calmodulin on CAMK2.

Gene Ontology (GO) - Molecular Function for CAMK2N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008427 calcium-dependent protein kinase inhibitor activity IEA --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with CAMK2N2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CAMK2N2 Gene

Localization for CAMK2N2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMK2N2 Gene

Nucleus. Cytoplasm, cytosol. Note=Excluded from nucleus when coexpressed with activated CAMK2. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for CAMK2N2 Gene COMPARTMENTS Subcellular localization image for CAMK2N2 gene
Compartment Confidence
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for CAMK2N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm --
GO:0005813 centrosome IDA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with CAMK2N2: view

Pathways for CAMK2N2 Gene

SuperPathways for CAMK2N2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CAMK2N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IEA --
genes like me logo Genes that share ontologies with CAMK2N2: view

No data available for Pathways by source for CAMK2N2 Gene

Transcripts for CAMK2N2 Gene

mRNA/cDNA for CAMK2N2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CAMK2N2 Gene

Calcium/calmodulin-dependent protein kinase II inhibitor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAMK2N2 Gene

No ASD Table

Relevant External Links for CAMK2N2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CAMK2N2 Gene

mRNA expression in normal human tissues for CAMK2N2 Gene

mRNA differential expression in normal tissues according to GTEx for CAMK2N2 Gene

This gene is overexpressed in Brain - Hypothalamus (6.3), Brain - Cerebellum (5.3), Brain - Cerebellar Hemisphere (5.0), and Brain - Amygdala (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CAMK2N2 Gene

SOURCE GeneReport for Unigene cluster for CAMK2N2 Gene Hs.585003

mRNA Expression by UniProt/SwissProt for CAMK2N2 Gene

Tissue specificity: Expressed in cell lines including hemopoietic cell lines and some tumor cell lines. Highly Expressed in stimulated dendritic cell (DC) and weakly expressed in unstimulated mature and immature DC. Highly expressed in kidney, liver, in cell lines HeLaS3, lymphoblastic leukemia MOLT-4, and Burkitts lymphoma Raji. Moderately expressed in heart, skeletal muscle, placenta, and chronic myelogenous leukemia K-562 cells. Weakly expressed in small intestine, colorectal adenocarcinoma SW480, and lung carcinoma A-549 cells.
genes like me logo Genes that share expressions with CAMK2N2: view

Orthologs for CAMK2N2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CAMK2N2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CAMK2N2 36
  • 100 (n)
  • 100 (a)
CAMK2N2 37
  • 100 (a)
(Bos Taurus)
Mammalia CAMK2N2 36
  • 97.05 (n)
  • 100 (a)
CAMK2N2 37
  • 100 (a)
(Canis familiaris)
Mammalia CAMK2N2 36
  • 96.2 (n)
  • 98.73 (a)
CAMK2N2 37
  • 99 (a)
(Mus musculus)
Mammalia Camk2n2 36
  • 95.36 (n)
  • 98.73 (a)
Camk2n2 16
Camk2n2 37
  • 99 (a)
(Monodelphis domestica)
Mammalia CAMK2N2 37
  • 99 (a)
(Rattus norvegicus)
Mammalia Camk2n2 36
  • 96.2 (n)
  • 98.73 (a)
(Gallus gallus)
Aves LOC101747380 36
  • 84.52 (n)
  • 76.79 (a)
(Anolis carolinensis)
Reptilia CAMK2N2 37
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia camk2n2 36
  • 75.11 (n)
  • 75.95 (a)
(Danio rerio)
Actinopterygii camk2n1a 36
  • 72.15 (n)
  • 73.42 (a)
camk2n1a 37
  • 73 (a)
camk2n2 37
  • 73 (a)
Species with no ortholog for CAMK2N2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAMK2N2 Gene

Gene Tree for CAMK2N2 (if available)
Gene Tree for CAMK2N2 (if available)

Paralogs for CAMK2N2 Gene

Paralogs for CAMK2N2 Gene

Selected SIMAP similar genes for CAMK2N2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CAMK2N2: view

Variants for CAMK2N2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CAMK2N2 Gene

Variant ID Type Subtype PubMed ID
nsv829812 CNV Loss 17160897
nsv878057 CNV Loss 21882294
dgv5354n71 CNV Loss 21882294
nsv878060 CNV Loss 21882294
nsv528639 CNV Loss 19592680
nsv4146 CNV Insertion 18451855
nsv878062 CNV Loss 21882294

Relevant External Links for CAMK2N2 Gene

HapMap Linkage Disequilibrium report

No data available for Sequence variations from dbSNP and Humsavar for CAMK2N2 Gene

Disorders for CAMK2N2 Gene

(1) MalaCards Diseases for CAMK2N2 Gene

Search for CAMK2N2 Gene in MalaCards »
genes like me logo Genes that share disorders with CAMK2N2: view

No data available for UniProtKB/Swiss-Prot for CAMK2N2 Gene

Publications for CAMK2N2 Gene

  1. Molecular cloning and characterization of a novel calcium/calmodulin- dependent protein kinase II inhibitor from human dendritic cells. (PMID: 11444830) Zhang J. … Cao X. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 23
  2. Endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest and apoptosis through down-regulation of the phosphatidylinositide 3-kinase/Akt/HDM2 pathway. (PMID: 19586909) Ma S. … Cao X. (J. Biol. Chem. 2009) 3 23
  3. Characterization of a calmodulin kinase II inhibitor protein in brain. (PMID: 9724800) Chang B.H. … Soderling T.R. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling. (PMID: 12531901) Okabe T. … Akiyama T. (J. Biol. Chem. 2003) 3

Products for CAMK2N2 Gene

Sources for CAMK2N2 Gene

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