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Aliases for CAMK2N2 Gene

Aliases for CAMK2N2 Gene

  • Calcium/Calmodulin Dependent Protein Kinase II Inhibitor 2 2 3
  • CaM-KII Inhibitory Protein 3 4
  • CAM-KIIN 3 4
  • Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor 2 5
  • CAMKIIN 3

External Ids for CAMK2N2 Gene

Previous GeneCards Identifiers for CAMK2N2 Gene

  • GC03M185461
  • GC03M183977
  • GC03M181384

Summaries for CAMK2N2 Gene

Entrez Gene Summary for CAMK2N2 Gene

  • This gene encodes a protein that is highly similar to the rat CaM-KII inhibitory protein, an inhibitor of calcium/calmodulin-dependent protein kinase II (CAMKII). CAMKII regulates numerous physiological functions, including neuronal synaptic plasticity through the phosphorylation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate (AMPA) receptors. Studies of the similar protein in rat suggest that this protein may function as a negative regulator of CaM-KII and may act to inhibit the phosphorylation of AMPA receptors. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAMK2N2 Gene

CAMK2N2 (Calcium/Calmodulin Dependent Protein Kinase II Inhibitor 2) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding and calcium-dependent protein kinase inhibitor activity. An important paralog of this gene is CAMK2N1.

UniProtKB/Swiss-Prot for CAMK2N2 Gene

  • Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells. Traps Ca(2+)/calmodulin on CAMK2.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMK2N2 Gene

Genomics for CAMK2N2 Gene

Regulatory Elements for CAMK2N2 Gene

Enhancers for CAMK2N2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CAMK2N2 on UCSC Golden Path with GeneCards custom track

Promoters for CAMK2N2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CAMK2N2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CAMK2N2 Gene

Chromosome:
3
Start:
184,259,213 bp from pter
End:
184,261,463 bp from pter
Size:
2,251 bases
Orientation:
Minus strand

Genomic View for CAMK2N2 Gene

Genes around CAMK2N2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAMK2N2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAMK2N2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMK2N2 Gene

Proteins for CAMK2N2 Gene

  • Protein details for CAMK2N2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S95-CK2N2_HUMAN
    Recommended name:
    Calcium/calmodulin-dependent protein kinase II inhibitor 2
    Protein Accession:
    Q96S95

    Protein attributes for CAMK2N2 Gene

    Size:
    79 amino acids
    Molecular mass:
    8658 Da
    Quaternary structure:
    • Interacts with CAMK2A and CAMK2B in the presence of Ca(2+)/calmodulin or after autophosphorylation.

neXtProt entry for CAMK2N2 Gene

Proteomics data for CAMK2N2 Gene at MOPED

Post-translational modifications for CAMK2N2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAMK2N2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CAMK2N2 Gene

Domains & Families for CAMK2N2 Gene

Protein Domains for CAMK2N2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CAMK2N2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96S95

UniProtKB/Swiss-Prot:

CK2N2_HUMAN :
  • The inhibitory domain blocks CAMK2 binding to GRIN2B.
  • Belongs to the CAMK2N family.
Domain:
  • The inhibitory domain blocks CAMK2 binding to GRIN2B.
Family:
  • Belongs to the CAMK2N family.
genes like me logo Genes that share domains with CAMK2N2: view

No data available for Gene Families for CAMK2N2 Gene

Function for CAMK2N2 Gene

Molecular function for CAMK2N2 Gene

UniProtKB/Swiss-Prot Function:
Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells. Traps Ca(2+)/calmodulin on CAMK2.

Gene Ontology (GO) - Molecular Function for CAMK2N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008427 calcium-dependent protein kinase inhibitor activity IEA --
genes like me logo Genes that share ontologies with CAMK2N2: view
genes like me logo Genes that share phenotypes with CAMK2N2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CAMK2N2 Gene

Localization for CAMK2N2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMK2N2 Gene

Nucleus. Cytoplasm, cytosol. Note=Excluded from nucleus when coexpressed with activated CAMK2. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAMK2N2 Gene COMPARTMENTS Subcellular localization image for CAMK2N2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for CAMK2N2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with CAMK2N2: view

Pathways & Interactions for CAMK2N2 Gene

SuperPathways for CAMK2N2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CAMK2N2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CAMK2N2 Gene

Drugs & Compounds for CAMK2N2 Gene

No Compound Related Data Available

Transcripts for CAMK2N2 Gene

mRNA/cDNA for CAMK2N2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CAMK2N2 Gene

Calcium/calmodulin-dependent protein kinase II inhibitor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAMK2N2 Gene

No ASD Table

Relevant External Links for CAMK2N2 Gene

GeneLoc Exon Structure for
CAMK2N2
ECgene alternative splicing isoforms for
CAMK2N2

Expression for CAMK2N2 Gene

mRNA expression in normal human tissues for CAMK2N2 Gene

mRNA differential expression in normal tissues according to GTEx for CAMK2N2 Gene

This gene is overexpressed in Brain - Hypothalamus (x6.3), Brain - Cerebellum (x5.3), Brain - Cerebellar Hemisphere (x5.0), and Brain - Amygdala (x4.7).

Protein differential expression in normal tissues from HIPED for CAMK2N2 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CAMK2N2 Gene



SOURCE GeneReport for Unigene cluster for CAMK2N2 Gene Hs.585003

mRNA Expression by UniProt/SwissProt for CAMK2N2 Gene

Q96S95-CK2N2_HUMAN
Tissue specificity: Expressed in cell lines including hemopoietic cell lines and some tumor cell lines. Highly Expressed in stimulated dendritic cell (DC) and weakly expressed in unstimulated mature and immature DC. Highly expressed in kidney, liver, in cell lines HeLaS3, lymphoblastic leukemia MOLT-4, and Burkitts lymphoma Raji. Moderately expressed in heart, skeletal muscle, placenta, and chronic myelogenous leukemia K-562 cells. Weakly expressed in small intestine, colorectal adenocarcinoma SW480, and lung carcinoma A-549 cells.
genes like me logo Genes that share expression patterns with CAMK2N2: view

Protein tissue co-expression partners for CAMK2N2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CAMK2N2 Gene

Orthologs for CAMK2N2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CAMK2N2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CAMK2N2 35
  • 97.05 (n)
  • 100 (a)
CAMK2N2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAMK2N2 35
  • 96.2 (n)
  • 98.73 (a)
CAMK2N2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Camk2n2 35
  • 95.36 (n)
  • 98.73 (a)
Camk2n2 16
Camk2n2 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CAMK2N2 35
  • 100 (n)
  • 100 (a)
CAMK2N2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Camk2n2 35
  • 96.2 (n)
  • 98.73 (a)
oppossum
(Monodelphis domestica)
Mammalia CAMK2N2 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101747380 35
  • 84.52 (n)
  • 76.79 (a)
lizard
(Anolis carolinensis)
Reptilia CAMK2N2 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia camk2n2 35
  • 75.11 (n)
  • 75.95 (a)
zebrafish
(Danio rerio)
Actinopterygii camk2n1a 35
  • 72.15 (n)
  • 73.42 (a)
camk2n1a 36
  • 73 (a)
OneToMany
camk2n2 36
  • 73 (a)
OneToMany
Species with no ortholog for CAMK2N2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAMK2N2 Gene

ENSEMBL:
Gene Tree for CAMK2N2 (if available)
TreeFam:
Gene Tree for CAMK2N2 (if available)

Paralogs for CAMK2N2 Gene

Paralogs for CAMK2N2 Gene

(1) SIMAP similar genes for CAMK2N2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CAMK2N2: view

Variants for CAMK2N2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CAMK2N2 Gene

Variant ID Type Subtype PubMed ID
nsv829812 CNV Loss 17160897
nsv878057 CNV Loss 21882294
dgv5354n71 CNV Loss 21882294
nsv878060 CNV Loss 21882294
nsv528639 CNV Loss 19592680
nsv4146 CNV Insertion 18451855
nsv878062 CNV Loss 21882294

Variation tolerance for CAMK2N2 Gene

Residual Variation Intolerance Score: 49.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.90% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for CAMK2N2 Gene

Disorders for CAMK2N2 Gene

Relevant External Links for CAMK2N2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAMK2N2

No disorders were found for CAMK2N2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAMK2N2 Gene

Publications for CAMK2N2 Gene

  1. Molecular cloning and characterization of a novel calcium/calmodulin- dependent protein kinase II inhibitor from human dendritic cells. (PMID: 11444830) Zhang J. … Cao X. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 23 67
  2. Endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest and apoptosis through down-regulation of the phosphatidylinositide 3-kinase/Akt/HDM2 pathway. (PMID: 19586909) Ma S. … Cao X. (J. Biol. Chem. 2009) 3 23
  3. Characterization of a calmodulin kinase II inhibitor protein in brain. (PMID: 9724800) Chang B.H. … Soderling T.R. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3
  4. A mega-analysis of genome-wide association studies for major depressive disorder. (PMID: 22472876) . … Sullivan P.F. (Mol. Psychiatry 2013) 3
  5. Downregulation of extracellular signal-regulated kinase 1/2 activity by calmodulin KII modulates p21Cip1 levels and survival of immortalized lymphocytes from Alzheimer's disease patients. (PMID: 23153928) Esteras N. … MartA-n-Requero A. (Neurobiol. Aging 2013) 3

Products for CAMK2N2 Gene

Sources for CAMK2N2 Gene

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