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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CAMK2N2 Gene

protein-coding   GIFtS: 42
GCID: GC03M183977

Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor 21 2
CaM-KII Inhibitory Protein2 3
CAMKIIN2 5
CAM-KIIN2
CaM-KIIN3

External Ids:    HGNC: 241971   Entrez Gene: 940322   Ensembl: ENSG000001638887   OMIM: 6087215   UniProtKB: Q96S953   

Export aliases for CAMK2N2 gene to outside databases

Previous GC identifers: GC03M185461 GC03M181384


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CAMK2N2 Gene:
This gene encodes a protein that is highly similar to the rat CaM-KII inhibitory protein, an inhibitor of
calcium/calmodulin-dependent protein kinase II (CAMKII). CAMKII regulates numerous physiological functions,
including neuronal synaptic plasticity through the phosphorylation of
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate (AMPA) receptors. Studies of the similar
protein in rat suggest that this protein may function as a negative regulator of CaM-KII and may act to inhibit
the phosphorylation of AMPA receptors. (provided by RefSeq, Jul 2008)

GeneCards Summary for CAMK2N2 Gene: 
CAMK2N2 (calcium/calmodulin-dependent protein kinase II inhibitor 2) is a protein-coding gene. Diseases associated with CAMK2N2 include colon adenocarcinoma, and burkitt's lymphoma. GO annotations related to this gene include calcium-dependent protein kinase inhibitor activity and protein kinase binding. An important paralog of this gene is CAMK2N1.

UniProtKB/Swiss-Prot: CK2N2_HUMAN, Q96S95
Function: Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May
play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells.
Traps Ca(2+)/calmodulin on CAMK2




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CAMK2N2 gene promoter:
         E2F-4   E2F-3a   E2F-5   Pax-5   E2F-2   NF-kappaB   E2F   E2F-1   STAT3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCAMK2N2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CAMK2N2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAMK2N2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27.1   Ensembl cytogenetic band:  3q27.1   HGNC cytogenetic band: 3q27.1

CAMK2N2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAMK2N2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M183977:  view genomic region     (about GC identifiers)

Start:
183,977,001 bp from pter      End:
183,979,251 bp from pter
Size:
2,251 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CK2N2_HUMAN, Q96S95 (See protein sequence)
Recommended Name: Calcium/calmodulin-dependent protein kinase II inhibitor 2  
Size: 79 amino acids; 8658 Da
Subunit: Interacts with CAMK2A and CAMK2B in the presence of Ca(2+)/calmodulin or after autophosphorylation (By
similarity)
Subcellular location: Nucleus. Cytoplasm, cytosol. Note=Excluded from nucleus when coexpressed with activated
CAMK2 (By similarity)

Explore the universe of human proteins at neXtProt for CAMK2N2: NX_Q96S95

Explore proteomics data for CAMK2N2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96S95

  • CAMK2N2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CAMK2N2 Protein Expression
    REFSEQ proteins: NP_150284.1  
    ENSEMBL proteins: 
     ENSP00000296238  

    Human Recombinant Protein Products for CAMK2N2: 
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    Cloud-Clone Corp. Proteins for CAMK2N2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol IEA--

    CAMK2N2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026779 Camk2n

    Graphical View of Domain Structure for InterPro Entry Q96S95

    ProtoNet protein and cluster: Q96S95

    UniProtKB/Swiss-Prot: CK2N2_HUMAN, Q96S95
    Domain: The inhibitory domain blocks CAMK2 binding to GRIN2B (By similarity)
    Similarity: Belongs to the CAMK2N family


    CAMK2N2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CK2N2_HUMAN, Q96S95
    Function: Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May
    play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells.
    Traps Ca(2+)/calmodulin on CAMK2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008427calcium-dependent protein kinase inhibitor activity IEA--
    GO:0019901protein kinase binding IEA--
         
    CAMK2N2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CAMK2N2 
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    SwitchGear 3'UTR luciferase reporter plasmidCAMK2N2 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CAMK2N2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for CAMK2N2 (Q96S953 ENSP000002962384) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARHGAP32A7KAX93, ENSP000003105614STRING: ENSP00000310561 I2D: score=1 
    CAMK2BQ135543, ENSP000002586824I2D: score=1 STRING: ENSP00000258682
    CAMK2AENSP000003814124STRING: ENSP00000381412
    --A8K1613I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CAMK2N2 (CK2N2)

    Search CenterWatch for drugs/clinical trials and news about CAMK2N2 / CK2N2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CAMK2N2 gene: 
    NM_033259.2  

    Unigene Cluster for CAMK2N2:

    Calcium/calmodulin-dependent protein kinase II inhibitor 2
    Hs.585003  [show with all ESTs]
    Unigene Representative Sequence: NM_033259
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000296238(uc003fnj.1)
    miRNA
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    hsa-miR-106a hsa-miR-346 hsa-miR-30d hsa-miR-486-3p hsa-miR-519a hsa-miR-30a hsa-miR-298 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidCAMK2N2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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                         Customized lentivirus expression plasmids for stable overexpression of CAMK2N2 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAMK2N2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAMK2N2

    Additional mRNA sequence: 

    AY037149.1 BC105077.1 BC105079.1 

    2 DOTS entries:

    DT.426551  DT.310960 

    6 AceView cDNA sequences:

    NM_033259 BX280361 AY037149 AI363920 BM966986 BM128638 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CAMK2N2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCAGTCTGC
    CAMK2N2 Expression
    About this image


    See CAMK2N2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CAMK2N2

    SOURCE GeneReport for Unigene cluster: Hs.585003

    UniProtKB/Swiss-Prot: CK2N2_HUMAN, Q96S95
    Tissue specificity: Expressed in cell lines including hemopoietic cell lines and some tumor cell lines. Highly
    Expressed in stimulated dendritic cell (DC) and weakly expressed in unstimulated mature and immature DC. Highly
    expressed in kidney, liver, in cell lines HeLaS3, lymphoblastic leukemia MOLT-4, and Burkitt's lymphoma Raji.
    Moderately expressed in heart, skeletal muscle, placenta, and chronic myelogenous leukemia K-562 cells. Weakly
    expressed in small intestine, colorectal adenocarcinoma SW480, and lung carcinoma A-549 cells

        SABiosciences Custom PCR Arrays for CAMK2N2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMK2N2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CAMK2N2 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Camk2n21 , 5 calcium/calmodulin-dependent protein kinase II inhibitor more1, 5 95.36(n)1
    98.73(a)1
      16 (12.48 cM)5
    730471  NM_028420.21  NP_082696.11 
     206192155 
    chicken
    (Gallus gallus)
    Aves LOC1008584651 calcium/calmodulin-dependent protein kinase II inhibitor more 84.52(n)
    76.79(a)
      100858465  XM_003641792.1  XP_003641840.1 
    lizard
    (Anolis carolinensis)
    Reptilia CAMK2N26
    Uncharacterized protein
    78(a)
    1 ↔ 1
    GL343245.1(513928-517306)
    zebrafish
    (Danio rerio)
    Actinopterygii camk2n1a1 calcium/calmodulin-dependent protein kinase II inhibitor more 72.15(n)
    73.42(a)
      553607  NM_001145089.2  NP_001138561.1 


    ENSEMBL Gene Tree for CAMK2N2 (if available)
    TreeFam Gene Tree for CAMK2N2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CAMK2N2 gene
    CAMK2N12  
    1 SIMAP similar gene for CAMK2N2 using alignment to 1 protein entry:     CK2N2_HUMAN:
    CAMK2N1

    CAMK2N2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CAMK2N2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv4146CNV Insertion18451855
    nsv878060CNV Loss21882294
    nsv878062CNV Loss21882294
    dgv5354n71CNV Loss21882294
    nsv829812CNV Loss17160897
    nsv528639CNV Loss19592680
    nsv878057CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608721    OMIM disorders: --

    8 diseases for CAMK2N2:    About MalaCards
    colon adenocarcinoma    burkitt's lymphoma    major depressive disorder    atherosclerosis
    adenocarcinoma    lymphoblastic leukemia    neuronitis    leukemia


    CAMK2N2 for disorders           About GeneDecksing


    Export disorders for CAMK2N2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CAMK2N2 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with CAMK2N2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel calcium/calmodulin- dependent protein kinase II inhibitor from human dendritic cells. (PubMed id 11444830)1, 2, 3, 9 Zhang J.... Cao X. (2001)
    2. Characterization of a calmodulin kinase II inhibitor protein in brain. (PubMed id 9724800)1, 3 Chang B.H....Soderling T.R. (1998)
    3. Endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest and apoptosis through down-regulati on of the phosphatidylinositide 3-kinase/Akt/HDM2 pathway. (PubMed id 19586909)1, 9 Ma S....Cao X. (2009)
    4. Genome wide array analysis indicates that an amyotroph ic lateral sclerosis mutation of FUS causes an early increase of CAMK2N2 in vitr o. (PubMed id 23545117)1 Convertini P....Stamm S. (2013)
    5. Downregulation of extracellular signal-regulated kinas e 1/2 activity by calmodulin KII modulates p21Cip1 levels and survival of immort alized lymphocytes from Alzheimer's disease patients. (PubMed id 23153928)1 Esteras N....Martin-Requero A. (2013)
    6. A mega-analysis of genome-wide association studies for major depressive disorder. (PubMed id 22472876)1 (2012)
    7. Biochemical and computational analysis of LNX1 interac ting proteins. (PubMed id 22087225)1 Wolting C.D....McGlade C.J. (2011)
    8. Differential regulation of CaMKII inhibitor beta prot ein expression after exposure to a novel context and during contextual fear mem ory formation. (PubMed id 20487031)1 RadwaA8ska K....Giese K.P. (2010)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling. (PubMed id 12531901)1 Okabe T.... Akiyama T. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 94032 HGNC: 24197 AceView: CAM-KIIN Ensembl:ENSG00000163888 euGenes: HUgn94032
    ECgene: CAMK2N2 H-InvDB: CAMK2N2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CAMK2N2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CAMK2N2 gene:
    Search GeneIP for patents involving CAMK2N2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Proteins for CAMK2N2
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMK2N2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CAMK2N2
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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