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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CAMK2N1 Gene

protein-coding   GIFtS: 44
GCID: GC01M020808

Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor 11 2     RP11-401M16.12
CaMKII Inhibitory Protein Alpha2 3     caMKIIN-alpha2
CaMKIINalpha2     CaMKIIN-alpha3
PRO14892     

External Ids:    HGNC: 241901   Entrez Gene: 554502   Ensembl: ENSG000001625457   OMIM: 6149865   UniProtKB: Q7Z7J93   

Export aliases for CAMK2N1 gene to outside databases

Previous GC identifers: GC01M020556 GC01M020681 GC01M019055


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CAMK2N1 Gene: 
CAMK2N1 (calcium/calmodulin-dependent protein kinase II inhibitor 1) is a protein-coding gene. Diseases associated with CAMK2N1 include ischemia, and cerebritis. GO annotations related to this gene include calcium-dependent protein kinase inhibitor activity and protein kinase binding. An important paralog of this gene is CAMK2N2.

UniProtKB/Swiss-Prot: CK2N1_HUMAN, Q7Z7J9
Function: Potent and specific inhibitor of CaM-kinase II (CAMK2) (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CAMK2N1 gene promoter:
         RFX1   Sp1   MyoD   C/EBPalpha   RORalpha1   HEN1   PPAR-gamma1   S8   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCAMK2N1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CAMK2N1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAMK2N1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.12   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36.12

CAMK2N1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAMK2N1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M020808:  view genomic region     (about GC identifiers)

Start:
20,808,884 bp from pter      End:
20,812,728 bp from pter
Size:
3,845 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CK2N1_HUMAN, Q7Z7J9 (See protein sequence)
Recommended Name: Calcium/calmodulin-dependent protein kinase II inhibitor 1  
Size: 78 amino acids; 8553 Da
Subunit: Interacts with CAMK2B; the presence of Ca(2+)/calmodulin increases the interaction but is not essential
(By similarity). Interacts with CAMK2A; this interaction requires CAMK2A activation by Ca(2+)
Subcellular location: Cell junction, synapse, synaptosome. Cell junction, synapse, postsynaptic cell membrane,
postsynaptic density (By similarity)
Developmental stage: Regulated in a cell cycle-dependent manner: abundant at S and G2/M phases and low in G0/G1
phase

Explore the universe of human proteins at neXtProt for CAMK2N1: NX_Q7Z7J9

Explore proteomics data for CAMK2N1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7Z7J9

  • CAMK2N1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CAMK2N1 Protein Expression
    REFSEQ proteins: NP_061054.2  
    ENSEMBL proteins: 
     ENSP00000364219  

    Human Recombinant Protein Products for CAMK2N1: 
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    Cloud-Clone Corp. Proteins for CAMK2N1 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0014069postsynaptic density IEA--
    GO:0030054cell junction IEA--
    GO:0030425dendrite IEA--
    GO:0043025neuronal cell body IEA--

    CAMK2N1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026779 Camk2n

    Graphical View of Domain Structure for InterPro Entry Q7Z7J9

    ProtoNet protein and cluster: Q7Z7J9

    UniProtKB/Swiss-Prot: CK2N1_HUMAN, Q7Z7J9
    Domain: CAMK2 inhibitory domain is also called 'conserved inhibitory region' or 27CIR
    Similarity: Belongs to the CAMK2N family


    CAMK2N1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CK2N1_HUMAN, Q7Z7J9
    Function: Potent and specific inhibitor of CaM-kinase II (CAMK2) (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004860protein kinase inhibitor activity ----
    GO:0008427calcium-dependent protein kinase inhibitor activity IEA--
    GO:0019901protein kinase binding IEA--
         
    CAMK2N1 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CAMK2N1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for CAMK2N1 (Q7Z7J93 ENSP000003642194) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRIN2BQ132243, ENSP000002795934I2D: score=1 STRING: ENSP00000279593
    ENSG00000112493ENSP000003785464STRING: ENSP00000378546
    ENSG00000206500ENSP000003731064STRING: ENSP00000373106
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006469negative regulation of protein kinase activity ----

    CAMK2N1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CAMK2N1 (CK2N1)

    Search CenterWatch for drugs/clinical trials and news about CAMK2N1 / CK2N1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CAMK2N1 gene: 
    NM_018584.5  

    Unigene Cluster for CAMK2N1:

    Calcium/calmodulin-dependent protein kinase II inhibitor 1
    Hs.731383  [show with all ESTs]
    Unigene Representative Sequence: NM_018584
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375078(uc001bdh.3) ENST00000489020
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    Additional mRNA sequence: 

    AY204901.1 BC020630.1 

    4 DOTS entries:

    DT.417037  DT.100758724  DT.40265830  DT.100758723 

    24/261 AceView cDNA sequences (see all 261):

    AI633980 CA444938 AI570417 AA989250 AA886382 AA991302 AI202597 AW058021 
    BM767489 AA158136 AA688395 BQ018365 CD629348 CA841061 AA683218 AA917393 
    BM713384 BF476438 AA890420 CB130186 CB306865 AI263272 AI571336 BQ000750 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CAMK2N1 expression in normal human tissues (normalized intensities)      CAMK2N1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTATTTGCAA
    CAMK2N1 Expression
    About this image


    CAMK2N1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 13 entries
             Thalamus
             Globus Pallidus   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Basal Cells Respiratory Bronchioles
             Human Pulmonary Artery Smooth Muscle Cells (HPASMC)   
     
     Smooth Muscle (Muscoskeletal System)
             Human Pulmonary Artery Smooth Muscle Cells (HPASMC)   
     
     Placenta (Extraembryonic Tissues)
             Decidua-derived mesenchymal cells
     
     Lower Urinary Tract (Urinary System)
             bladder   

    See CAMK2N1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CAMK2N1

    SOURCE GeneReport for Unigene cluster: Hs.731383

    UniProtKB/Swiss-Prot: CK2N1_HUMAN, Q7Z7J9
    Tissue specificity: Widely expressed. Nor detected in skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Array including CAMK2N1: 
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for CAMK2N1 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Camk2n11 , 5 calcium/calmodulin-dependent protein kinase II inhibitor more1, 5 96.15(n)1
    97.44(a)1
      4 (70.30 cM)5
    662591  NM_025451.21  NP_079727.11 
     1384543145 


    ENSEMBL Gene Tree for CAMK2N1 (if available)
    TreeFam Gene Tree for CAMK2N1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CAMK2N1 gene
    CAMK2N22  
    1 SIMAP similar gene for CAMK2N1 using alignment to 2 protein entries:     CK2N1_HUMAN (see all proteins):
    CAMK2N2

    CAMK2N1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/85 SNPs in CAMK2N1 are shown (see all 85)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs4368751,2
    C,F--20808405(-) CAGCAC/TATGGG 1 -- ds50014Minor allele frequency- T:0.12WA NA 242
    rs772009601,2
    C,F--20808431(+) TCCTAA/CTAACC 1 -- ds50012Minor allele frequency- C:0.12NA EA 240
    rs124042021,2
    H--20808512(+) acctaG/Tgaagt 1 -- ds50014Minor allele frequency- T:0.00NS EA 388
    rs1162080931,2
    F--20808644(+) CAGGGA/TTGCAG 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1154458501,2
    F--20808658(+) GAGCTC/TAACCT 1 -- ds50011Minor allele frequency- T:0.01NA 120
    rs412650531,2
    F--20808773(+) TTTTGC/ACTCGC 1 -- ds50011Minor allele frequency- A:0.06NA 120
    rs1500016211,2
    C--20808795(+) ACCAT-/CCCTCC 1 -- ds50010--------
    rs284109661,2
    C--20809057(+) GCAAGA/GGGCAT 1 -- ut31 ese32Minor allele frequency- G:0.00NA 4
    rs115390801,2
    C,F--20809314(-) TTCTAA/CCTTCC 1 -- ut311Minor allele frequency- C:0.05NA 120
    rs6879221,2
    C--20809342(-) AAAACA/GAAGAA 1 -- ut31 trp35Minor allele frequency- G:0.00EA NA MN 242

    HapMap Linkage Disequilibrium report for CAMK2N1 (20808884 - 20812728 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CAMK2N1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv821943CNV Gain20364138

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614986    OMIM disorders: --

    3 diseases for CAMK2N1:    About MalaCards
    ischemia    cerebritis    neuronitis


    CAMK2N1 for disorders           About GeneDecksing


    Export disorders for CAMK2N1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CAMK2N1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CAMK2N1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization. (PubMed id 18305109)1, 2 Wang C....Cao X. (2008)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    5. Autophosphorylated calcium/calmodulin-dependent protein kinase II alpha (CaMKII alpha) reversibly targets to and phosphorylates N-methyl-D-aspartate receptor subunit 2B (NR2B) in cerebral ischemia and reperfusion in hippocampus of rats. (PubMed id 12650977)1 Meng F....Zhang G. (2003)
    6. Phosphorylation of the recombinant rho1 GABA receptor. (PubMed id 12175859)1 Sedelnikova A. and Weiss D.S. (2002)
    7. Simulation of Ca-calmodulin-dependent protein kinase II on rabbit ventricular myocyte ion currents and action potentials. (PubMed id 17704163)9 Grandi E....Bers D.M. (2007)
    8. Mechanisms of potentiation of mossy fiber EPSCs in the cerebellar nuclei by coincident synaptic excitation and inhibition. (PubMed id 18923031)9 Pugh J.R. and Raman I.M. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55450 HGNC: 24190 AceView: CaMKIINalpha Ensembl:ENSG00000162545 euGenes: HUgn55450
    ECgene: CAMK2N1 H-InvDB: CAMK2N1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CAMK2N1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CAMK2N1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CAMK2N1 gene:
    Search GeneIP for patents involving CAMK2N1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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