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Aliases for CAMK2N1 Gene

Aliases for CAMK2N1 Gene

  • Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor 1 2 3
  • CaMKII Inhibitory Protein Alpha 3 4
  • CaMKIIN-Alpha 3 4
  • CaMKIINalpha 3
  • PRO1489 3

External Ids for CAMK2N1 Gene

Previous GeneCards Identifiers for CAMK2N1 Gene

  • GC01M020556
  • GC01M020681
  • GC01M020808
  • GC01M019055

Summaries for CAMK2N1 Gene

GeneCards Summary for CAMK2N1 Gene

CAMK2N1 (Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor 1) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding and calcium-dependent protein kinase inhibitor activity. An important paralog of this gene is CAMK2N2.

UniProtKB/Swiss-Prot for CAMK2N1 Gene

  • Potent and specific inhibitor of CaM-kinase II (CAMK2).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMK2N1 Gene

Genomics for CAMK2N1 Gene

Regulatory Elements for CAMK2N1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CAMK2N1 Gene

20,482,391 bp from pter
20,486,235 bp from pter
3,845 bases
Minus strand

Genomic View for CAMK2N1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAMK2N1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMK2N1 Gene

Proteins for CAMK2N1 Gene

  • Protein details for CAMK2N1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcium/calmodulin-dependent protein kinase II inhibitor 1
    Protein Accession:
    Secondary Accessions:

    Protein attributes for CAMK2N1 Gene

    78 amino acids
    Molecular mass:
    8553 Da
    Quaternary structure:
    • Interacts with CAMK2B; the presence of Ca(2+)/calmodulin increases the interaction but is not essential (By similarity). Interacts with CAMK2A; this interaction requires CAMK2A activation by Ca(2+).

neXtProt entry for CAMK2N1 Gene

Proteomics data for CAMK2N1 Gene at MOPED

Post-translational modifications for CAMK2N1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAMK2N1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CAMK2N1 Gene

Domains for CAMK2N1 Gene

Protein Domains for CAMK2N1 Gene


Suggested Antigen Peptide Sequences for CAMK2N1 Gene

Graphical View of Domain Structure for InterPro Entry



  • CAMK2 inhibitory domain is also called conserved inhibitory region or 27CIR
  • Belongs to the CAMK2N family.
  • CAMK2 inhibitory domain is also called conserved inhibitory region or 27CIR
  • Belongs to the CAMK2N family.
genes like me logo Genes that share domains with CAMK2N1: view

No data available for Gene Families for CAMK2N1 Gene

Function for CAMK2N1 Gene

Molecular function for CAMK2N1 Gene

UniProtKB/Swiss-Prot Function:
Potent and specific inhibitor of CaM-kinase II (CAMK2).

Gene Ontology (GO) - Molecular Function for CAMK2N1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity --
GO:0008427 calcium-dependent protein kinase inhibitor activity IEA --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with CAMK2N1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CAMK2N1 Gene

Localization for CAMK2N1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMK2N1 Gene

Cell junction, synapse, synaptosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.

Subcellular locations from

Jensen Localization Image for CAMK2N1 Gene COMPARTMENTS Subcellular localization image for CAMK2N1 gene
Compartment Confidence
cytosol 3
plasma membrane 3
cytoskeleton 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for CAMK2N1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014069 postsynaptic density IEA --
GO:0030054 cell junction IEA --
GO:0030425 dendrite IEA --
GO:0043025 neuronal cell body IEA --
GO:0045202 synapse --
genes like me logo Genes that share ontologies with CAMK2N1: view

Pathways for CAMK2N1 Gene

SuperPathways for CAMK2N1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for CAMK2N1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000364219 Q7Z7J9-CK2N1_HUMAN for CAMK2N1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CAMK2N1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IEA --
genes like me logo Genes that share ontologies with CAMK2N1: view

No data available for Pathways by source for CAMK2N1 Gene

Transcripts for CAMK2N1 Gene

mRNA/cDNA for CAMK2N1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(261) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CAMK2N1 Gene

Calcium/calmodulin-dependent protein kinase II inhibitor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAMK2N1 Gene

No ASD Table

Relevant External Links for CAMK2N1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CAMK2N1 Gene

mRNA expression in normal human tissues for CAMK2N1 Gene

mRNA differential expression in normal tissues according to GTEx for CAMK2N1 Gene

This gene is overexpressed in Brain - Amygdala (6.5), Brain - Anterior cingulate cortex (BA24) (6.3), Brain - Frontal Cortex (BA9) (5.9), Brain - Cortex (5.5), and Brain - Hippocampus (4.0).

Protein differential expression in normal tissues for CAMK2N1 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CAMK2N1 Gene

SOURCE GeneReport for Unigene cluster for CAMK2N1 Gene Hs.731383

mRNA Expression by UniProt/SwissProt for CAMK2N1 Gene

Tissue specificity: Widely expressed. Nor detected in skeletal muscle.
genes like me logo Genes that share expressions with CAMK2N1: view

Expression partners for CAMK2N1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for CAMK2N1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CAMK2N1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CAMK2N1 35
  • 98.29 (n)
  • 98.72 (a)
CAMK2N1 36
  • 99 (a)
(Mus musculus)
Mammalia Camk2n1 35
  • 96.15 (n)
  • 97.44 (a)
Camk2n1 16
Camk2n1 36
  • 97 (a)
(Pan troglodytes)
Mammalia CAMK2N1 35
  • 100 (n)
  • 100 (a)
CAMK2N1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Camk2n1 35
  • 97.44 (n)
  • 97.44 (a)
Species with no ortholog for CAMK2N1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CAMK2N1 Gene

Gene Tree for CAMK2N1 (if available)
Gene Tree for CAMK2N1 (if available)

Paralogs for CAMK2N1 Gene

Paralogs for CAMK2N1 Gene

(1) SIMAP similar genes for CAMK2N1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CAMK2N1: view

Variants for CAMK2N1 Gene

Sequence variations from dbSNP and Humsavar for CAMK2N1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs436875 -- 20,481,912(-) CAGCA(C/T)ATGGG downstream-variant-500B
rs687922 -- 20,482,849(-) AAAAC(A/G)AAGAA utr-variant-3-prime
rs1152984 -- 20,488,029(+) GCCAA(A/G)GCCAA upstream-variant-2KB
rs1253918 -- 20,486,995(+) TGAGA(G/T)GAGGA upstream-variant-2KB
rs1253919 -- 20,487,141(+) CTGCC(C/T)TCCGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CAMK2N1 Gene

Variant ID Type Subtype PubMed ID
nsv821943 CNV Gain 20364138

Relevant External Links for CAMK2N1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMK2N1 Gene

Disorders for CAMK2N1 Gene

No disorders were found for CAMK2N1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for CAMK2N1 Gene

Publications for CAMK2N1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization. (PMID: 18305109) Wang C. … Cao X. (J. Biol. Chem. 2008) 3 4
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4
  5. Autophosphorylated calcium/calmodulin-dependent protein kinase II alpha (CaMKII alpha) reversibly targets to and phosphorylates N-methyl-D-aspartate receptor subunit 2B (NR2B) in cerebral ischemia and reperfusion in hippocampus of rats. (PMID: 12650977) Meng F. … Zhang G. (Brain Res. 2003) 3

Products for CAMK2N1 Gene

Sources for CAMK2N1 Gene

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