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Aliases for CAMK2N1 Gene

Aliases for CAMK2N1 Gene

  • Calcium/Calmodulin Dependent Protein Kinase II Inhibitor 1 2 3 5
  • CaMKII Inhibitory Protein Alpha 3 4
  • CaMKIIN-Alpha 3 4
  • Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor 1 3
  • CaMKIINalpha 3
  • PRO1489 3

External Ids for CAMK2N1 Gene

Previous GeneCards Identifiers for CAMK2N1 Gene

  • GC01M020556
  • GC01M020681
  • GC01M020808
  • GC01M019055

Summaries for CAMK2N1 Gene

GeneCards Summary for CAMK2N1 Gene

CAMK2N1 (Calcium/Calmodulin Dependent Protein Kinase II Inhibitor 1) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding and calcium-dependent protein kinase inhibitor activity. An important paralog of this gene is CAMK2N2.

UniProtKB/Swiss-Prot for CAMK2N1 Gene

  • Potent and specific inhibitor of CaM-kinase II (CAMK2).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMK2N1 Gene

Genomics for CAMK2N1 Gene

Regulatory Elements for CAMK2N1 Gene

Enhancers for CAMK2N1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G020210 1.4 Ensembl ENCODE dbSUPER 20.7 +274.2 274242 3.1 HDAC1 PKNOX1 FOXA2 TBL1XR1 NFIB RAD21 ETS1 ZNF766 ZNF143 FOS CAMK2N1 MUL1 VWA5B1 ENSG00000226664 UBXN10 LOC105376826 LOC105376825
GH01G020474 2 FANTOM5 Ensembl ENCODE dbSUPER 8.1 +5.2 5154 13.8 HNRNPUL1 PKNOX1 FOXA2 MLX ARID4B DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 MUL1 FAM43B DDOST CAMK2N1 LINC01141
GH01G020440 0.8 dbSUPER 15.7 +44.6 44597 2.3 IRF2 USF1 CREB3L1 SUZ12 ZNF76 MAX ETS1 DIDO1 NFYB ZNF143 CAMK2N1 MUL1 ENSG00000226664 LINC01141
GH01G020461 1 dbSUPER 11.5 +23.8 23765 2.7 PKNOX1 ARNT ZFP64 SIN3A FEZF1 YY1 ZNF766 ZNF207 KLF7 TSHZ1 MUL1 CAMK2N1 VWA5B1 LINC01141
GH01G019918 1 Ensembl ENCODE 10.1 +567.5 567503 1.2 CTCF RB1 WRNIP1 ARID4B ZNF384 ZNF2 HBP1 RAD21 TEAD3 SCRT2 CAMK2N1 OTUD3 PLA2G2E PIR55587
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CAMK2N1 on UCSC Golden Path with GeneCards custom track

Promoters for CAMK2N1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000002619 735 3001 ARID4B DMAP1 ZNF2 ZBTB7B SLC30A9 ZNF548 PAF1 ZNF263 SP3 SP5

Genomic Location for CAMK2N1 Gene

Chromosome:
1
Start:
20,482,391 bp from pter
End:
20,486,235 bp from pter
Size:
3,845 bases
Orientation:
Minus strand

Genomic View for CAMK2N1 Gene

Genes around CAMK2N1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAMK2N1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAMK2N1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMK2N1 Gene

Proteins for CAMK2N1 Gene

  • Protein details for CAMK2N1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7J9-CK2N1_HUMAN
    Recommended name:
    Calcium/calmodulin-dependent protein kinase II inhibitor 1
    Protein Accession:
    Q7Z7J9

    Protein attributes for CAMK2N1 Gene

    Size:
    78 amino acids
    Molecular mass:
    8553 Da
    Quaternary structure:
    • Interacts with CAMK2B; the presence of Ca(2+)/calmodulin increases the interaction but is not essential (By similarity). Interacts with CAMK2A; this interaction requires CAMK2A activation by Ca(2+).

neXtProt entry for CAMK2N1 Gene

Post-translational modifications for CAMK2N1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAMK2N1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CAMK2N1 Gene

Domains & Families for CAMK2N1 Gene

Protein Domains for CAMK2N1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CAMK2N1 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z7J9

UniProtKB/Swiss-Prot:

CK2N1_HUMAN :
  • CAMK2 inhibitory domain is also called conserved inhibitory region or 27CIR.
  • Belongs to the CAMK2N family.
Domain:
  • CAMK2 inhibitory domain is also called conserved inhibitory region or 27CIR.
Family:
  • Belongs to the CAMK2N family.
genes like me logo Genes that share domains with CAMK2N1: view

No data available for Gene Families for CAMK2N1 Gene

Function for CAMK2N1 Gene

Molecular function for CAMK2N1 Gene

UniProtKB/Swiss-Prot Function:
Potent and specific inhibitor of CaM-kinase II (CAMK2).

Gene Ontology (GO) - Molecular Function for CAMK2N1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008427 calcium-dependent protein kinase inhibitor activity IEA --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with CAMK2N1: view
genes like me logo Genes that share phenotypes with CAMK2N1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CAMK2N1 Gene

Localization for CAMK2N1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMK2N1 Gene

Cell junction, synapse, synaptosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAMK2N1 gene
Compartment Confidence
plasma membrane 3
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for CAMK2N1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with CAMK2N1: view

Pathways & Interactions for CAMK2N1 Gene

SuperPathways for CAMK2N1 Gene

No Data Available

Interacting Proteins for CAMK2N1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000364219%0d%0a9606.ENSP00000279593%0d%0a9606.ENSP00000291182%0d%0a9606.ENSP00000360069%0d%0a
Selected Interacting proteins: Q7Z7J9-CK2N1_HUMAN ENSP00000364219 for CAMK2N1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for CAMK2N1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IEA --
genes like me logo Genes that share ontologies with CAMK2N1: view

No data available for Pathways by source and SIGNOR curated interactions for CAMK2N1 Gene

Drugs & Compounds for CAMK2N1 Gene

No Compound Related Data Available

Transcripts for CAMK2N1 Gene

mRNA/cDNA for CAMK2N1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(261) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CAMK2N1 Gene

Calcium/calmodulin-dependent protein kinase II inhibitor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAMK2N1 Gene

No ASD Table

Relevant External Links for CAMK2N1 Gene

GeneLoc Exon Structure for
CAMK2N1
ECgene alternative splicing isoforms for
CAMK2N1

Expression for CAMK2N1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAMK2N1 Gene

mRNA differential expression in normal tissues according to GTEx for CAMK2N1 Gene

This gene is overexpressed in Brain - Amygdala (x6.5), Brain - Anterior cingulate cortex (BA24) (x6.3), Brain - Frontal Cortex (BA9) (x5.9), Brain - Cortex (x5.5), and Brain - Hippocampus (x4.0).

Protein differential expression in normal tissues from HIPED for CAMK2N1 Gene

This gene is overexpressed in Fetal Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CAMK2N1 Gene



Protein tissue co-expression partners for CAMK2N1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CAMK2N1 Gene:

CAMK2N1

SOURCE GeneReport for Unigene cluster for CAMK2N1 Gene:

Hs.731383

mRNA Expression by UniProt/SwissProt for CAMK2N1 Gene:

Q7Z7J9-CK2N1_HUMAN
Tissue specificity: Widely expressed. Nor detected in skeletal muscle.

Evidence on tissue expression from TISSUES for CAMK2N1 Gene

  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with CAMK2N1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CAMK2N1 Gene

Orthologs for CAMK2N1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CAMK2N1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAMK2N1 34 35
  • 100 (n)
cow
(Bos Taurus)
Mammalia CAMK2N1 34 35
  • 98.29 (n)
rat
(Rattus norvegicus)
Mammalia Camk2n1 34
  • 97.44 (n)
mouse
(Mus musculus)
Mammalia Camk2n1 34 16 35
  • 96.15 (n)
Species where no ortholog for CAMK2N1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CAMK2N1 Gene

ENSEMBL:
Gene Tree for CAMK2N1 (if available)
TreeFam:
Gene Tree for CAMK2N1 (if available)

Paralogs for CAMK2N1 Gene

Paralogs for CAMK2N1 Gene

(1) SIMAP similar genes for CAMK2N1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CAMK2N1: view

Variants for CAMK2N1 Gene

Sequence variations from dbSNP and Humsavar for CAMK2N1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000278214 -- 20,485,595(+) GCGCT(A/G)CGCTC utr-variant-5-prime
rs1000558786 -- 20,485,701(+) GGCCG(C/G)GAGCC utr-variant-5-prime
rs1001369413 -- 20,486,011(+) GGAGA(C/G)GGGGA utr-variant-5-prime
rs1001443157 -- 20,485,629(+) TGCTC(C/T)GCCAG utr-variant-5-prime
rs1002437847 -- 20,484,365(+) CTCTT(-/ACC)GTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAMK2N1 Gene

Variant ID Type Subtype PubMed ID
nsv1077198 CNV deletion 25765185
nsv545731 CNV gain 21841781
nsv821943 CNV gain 20364138
nsv954900 CNV deletion 24416366

Variation tolerance for CAMK2N1 Gene

Residual Variation Intolerance Score: 54.8% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAMK2N1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAMK2N1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMK2N1 Gene

Disorders for CAMK2N1 Gene

Relevant External Links for CAMK2N1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAMK2N1

No disorders were found for CAMK2N1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAMK2N1 Gene

Publications for CAMK2N1 Gene

  1. A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization. (PMID: 18305109) Wang C. … Cao X. (J. Biol. Chem. 2008) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Human gingiva transcriptome during wound healing. (PMID: 28005267) Wang Y. … Tatakis D.N. (J. Clin. Periodontol. 2017) 3 64
  4. RUNX3 and CAMK2N1 hypermethylation as prognostic marker for epithelial ovarian cancer. (PMID: 26175272) HAofner N. … Runnebaum I.B. (Int. J. Cancer 2016) 3 64
  5. The tumor suppressive role of CAMK2N1 in castration-resistant prostate cancer. (PMID: 25003983) Wang T. … Chen K. (Oncotarget 2014) 3 64

Products for CAMK2N1 Gene

Sources for CAMK2N1 Gene

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