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CAMK2G Gene

protein-coding   GIFtS: 70
GCID: GC10M075572

Calcium/Calmodulin-Dependent Protein Kinase II Gamma

(Previous name: calcium/calmodulin-dependent protein kinase (CaM kinase)...)
(Previous symbol: CAMKG)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calcium/Calmodulin-Dependent Protein Kinase II Gamma1 2     CAMK-II2 3
CAMKG1 2 3 5     EC 2.7.11.173 8
Calcium/Calmodulin-Dependent Protein Kinase (CaM Kinase) II Gamma1 2     Calcium/Calmodulin-Dependent Protein Kinase Type II Subunit Gamma2
CaMK-II Subunit Gamma2 3     CaM Kinase II Subunit Gamma3
CAMK2 3     EC 2.7.118

External Ids:    HGNC: 14631   Entrez Gene: 8182   Ensembl: ENSG000001486607   OMIM: 6021235   UniProtKB: Q135553   

Export aliases for CAMK2G gene to outside databases

Previous GC identifers: GC10M074352 GC10M074675 GC10M075464 GC10M074916 GC10M075242 GC10M069567


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CAMK2G Gene:
The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein
kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for
several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four
different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively
spliced transcripts encoding different isoforms have been described but the full-length nature of all the
variants has not been determined.(provided by RefSeq, Mar 2011)

GeneCards Summary for CAMK2G Gene:
CAMK2G (calcium/calmodulin-dependent protein kinase II gamma) is a protein-coding gene. Diseases associated with CAMK2G include timothy syndrome, and usher syndrome, type 1f. GO annotations related to this gene include calmodulin binding and calcium-dependent protein serine/threonine phosphatase activity. An important paralog of this gene is PNCK.

UniProtKB/Swiss-Prot: KCC2G_HUMAN, Q13555
Function: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding
and autophosphorylation, and is involved in sarcoplsamic reticulum Ca(2+) transport in skeletal muscle and may
function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in
regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control
of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In
neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic
plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning

summary for CAMK2G Gene:
Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second
messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through
autoinhibition. Increases in Ca2+ levels allows calmodulin to relieve this autoinhibition and activate the
kinase activity. There are two main classes of CaMKs; mulitfunctional CaMKs (CaMKK, CaMKI, CaMKII and
CaMKIV) which have multiple downstream targets and substrate-specific CaMKs (CaMKIII) which have only one
known downstream target. All CaMKs, with the exception of CaMKII, exist as monomers and most are expressed
ubiquitously. Some subtypes display specific distributions, for example, CaMKIVbeta is expressed exclusively
in cerebellar granule cells. CaMKs have numerous cellular functions and they influence processes as diverse
as gene transcription, cell survival, apoptosis, cytoskeletal re-organization and learning and memory.

Gene Wiki entry for CAMK2G Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CAMK2G gene promoter:
         STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCAMK2G promoter sequence
   Search Chromatin IP Primers for CAMK2G

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CAMK2G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22   Ensembl cytogenetic band:  10q22.2   HGNC cytogenetic band: 10q22

CAMK2G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAMK2G gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M075572:  view genomic region     (about GC identifiers)

Start:
75,572,259 bp from pter      End:
75,634,349 bp from pter
Size:
62,091 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KCC2G_HUMAN, Q13555 (See protein sequence)
Recommended Name: Calcium/calmodulin-dependent protein kinase type II subunit gamma  
Size: 558 amino acids; 62609 Da
Subunit: CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta
(CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with
two hexameric rings stacked one on top of the other
Sequence caution: Sequence=AAB61379.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
2 PDB 3D structures from and Proteopedia for CAMK2G:
2UX0 (3D)        2V7O (3D)    
Secondary accessions: O00561 O15378 Q13279 Q13282 Q13556 Q5SQZ3 Q5SQZ4 Q5SWX4 Q7KYX5 Q8N4I3
Q8NIA4
Alternative splicing: 10 isoforms:  Q13555-1   Q13555-2   Q13555-3   Q13555-4   Q13555-5   Q13555-6   Q13555-7   Q13555-8   
Q13555-9   Q13555-10   (Contains a phosphoserine at position 325)

Explore the universe of human proteins at neXtProt for CAMK2G: NX_Q13555

Explore proteomics data for CAMK2G at MOPED

Post-translational modifications: 

  • Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the
    kinase into an activated state1
  • Ubiquitination2 at Lys259
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CAMK2G (Q13555) (see all 41)
     TEQLIEA  YTKICDP  PYGKPVD  LADFGLA 


    See CAMK2G Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001191421.1  NP_001213.2  NP_751909.1  NP_751910.1  NP_751911.1  NP_751913.1  

    ENSEMBL proteins: 
     ENSP00000277853   ENSP00000315599   ENSP00000393784   ENSP00000307082   ENSP00000361851  
     ENSP00000405561   ENSP00000410298   ENSP00000319060   ENSP00000378243   ENSP00000399680  
    Reactome Protein details: Q13555

    CAMK2G Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CAMK2G Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CAMK2G
    OriGene Protein Over-expression Lysate for CAMK2G
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CAMK2G
    GenScript Custom Purified and Recombinant Proteins Services for CAMK2G
    Novus Biologicals CAMK2G Protein
    Novus Biologicals CAMK2G Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    CAMK2G Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CAMK2G
    R&D Systems Antibodies for CAMK2G (CaM Kinase II gamma)
    Cell Signaling Technology (CST) Antibodies for CAMK2G 
    OriGene Antibodies for CAMK2G
    OriGene Custom Antibody Services for CAMK2G
    Novus Biologicals CAMK2G Antibodies
    Abcam antibodies for CAMK2G (Q13555, Q9UQM7, Q13557, Q13554)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CAMK2G
    LSBio Antibodies in human, mouse, rat for CAMK2G

    CAMK2G Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CAMK2G
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CAMK2G
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: calcium/calmodulin-dependent protein kinase II gamma subunit
    CAMK2 family
    Selected non-AGC protein kinase activities

    Selected InterPro protein domains (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q13555

    ProtoNet protein and cluster: Q13555

    1 Blocks protein domain: IPB013543 Calcium/calmodulin dependent protein kinase II

    UniProtKB/Swiss-Prot: KCC2G_HUMAN, Q13555
    Domain: The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for
    oligomerization
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily
    Similarity: Contains 1 protein kinase domain


    CAMK2G for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCC2G_HUMAN, Q13555
    Function: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding
    and autophosphorylation, and is involved in sarcoplsamic reticulum Ca(2+) transport in skeletal muscle and may
    function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in
    regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control
    of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In
    neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic
    plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that
    relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a
    constitutively active form and confers to the kinase a Ca(2+)-independent activity
    Induction: Activity is induced in skeletal muscle during exercise

         Genatlas biochemistry entry for CAMK2G:
    protein kinase,calcium/calmodulin dependent,gammasubunit with several isoforms

         Enzyme Numbers (IUBMB): EC 2.7.11.171 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004683calmodulin-dependent protein kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0004723calcium-dependent protein serine/threonine phosphatase activity NAS9060999
         
    CAMK2G for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for CAMK2G:
     Decreased substrate adherent c  Decreased viability of wild-ty  Increased G1 DNA content  Increased telomerase activity 
     Paclitaxel antagonistic effect  Synthetic lethal with imatinib 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Camk2g):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  no phenotypic analysis 
     reproductive system 

    CAMK2G for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Camk2gtm1.1Irt for CAMK2G

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CAMK2G
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CAMK2G

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAMK2G
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAMK2G

    miRNA
    Products:
        
    miRTarBase miRNAs that target CAMK2G:
    hsa-mir-1 (MIRT024052), hsa-mir-331-3p (MIRT043311), hsa-mir-16-5p (MIRT031976), hsa-mir-219a-5p (MIRT004446)

    Block miRNA regulation of human, mouse, rat CAMK2G using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CAMK2G (see all 75):
    hsa-miR-219-5p hsa-miR-371-5p hsa-miR-510 hsa-miR-647 hsa-miR-4289 hsa-miR-4300 hsa-miR-4297 hsa-miR-920
    SwitchGear 3'UTR luciferase reporter plasmidCAMK2G 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CAMK2G
    Predesigned siRNA for gene silencing in human, mouse, rat CAMK2G

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CAMK2G

    Clone
    Products:
         
    OriGene clones in human, mouse for CAMK2G (see all 32)
    OriGene ORF clones in mouse, rat for CAMK2G
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): CAMK2G (NM_172169)
    Sino Biological Human cDNA Clone for CAMK2G
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAMK2G
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMK2G

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CAMK2G
    Browse ESI BIO Cell Lines and PureStem Progenitors for CAMK2G 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMK2G


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KCC2G_HUMAN, Q13555: Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytosol4
    nucleus4
    plasma membrane4
    cytoskeleton2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0005954calcium- and calmodulin-dependent protein kinase complex TAS11264466
    GO:0030666endocytic vesicle membrane TAS--

    CAMK2G for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CAMK2G About   (see all 53)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathways0.40
    2Post NMDA receptor activation events
    Post NMDA receptor activation events0.90
    Ras activation uopn Ca2+ infux through NMDA receptor0.00
    Activation of NMDA receptor upon glutamate binding and postsynaptic events0.90
    Unblocking of NMDA receptor, glutamate binding and activation0.00
    CREB phosphorylation through the activation of Ras0.78
    CREB phosphorylation through the activation of CaMKII0.00
    Long-term potentiation0.35
    3Development Endothelin 1 EDNRA signaling
    Development Endothelin 1 EDNRA signaling0.41
    GnRH signaling pathway0.38
    Development Endothelin 1 EDNRA transactivation of EGFR0.41
    Inflammatory mediator regulation of TRP channels0.37
    Cytoskeleton remodeling FAK signaling0.41
    4ErbB signaling pathway
    ErbB signaling pathway0.52
    EGFR Inhibitor Pathway, Pharmacodynamics0.49
    5Immune response IFN gamma signaling pathway
    IFN-gamma pathway0.43
    Immune response IFN gamma signaling pathway0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CAMK2G
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CAMK2G (see all 18)
        Molecular Mechanisms of Cancer
    PI3K Signaling in B-Lymphocyte
    Melatonin Signaling
    IP3 Pathway
    CREB Pathway

    2 Cell Signaling Technology (CST) Pathways for CAMK2G
        Ca, cAMP and Lipid Signaling
    Neuroscience

    Selected GeneGo (Thomson Reuters) Pathways for CAMK2G (see all 18)
        Development Endothelin-1/EDNRA transactivation of EGFR
    Signal transduction cAMP signaling
    Development Endothelin-1/EDNRA signaling
    Development Angiotensin signaling via PYK2
    Development Activation of ERK by Alpha-1 adrenergic receptors

    Selected BioSystems Pathways for CAMK2G (see all 8)
        Myometrial Relaxation and Contraction Pathways
    Calcium Regulation in the Cardiac Cell
    TGF-beta Receptor Signaling Pathway
    Wnt Signaling Pathway NetPath
    Energy Metabolism

    2 Sino Biological Pathways for CAMK2G
        EGFR Signaling Pathway
    Non-Canonical Wnt Pathway

    Selected Reactome Pathways for CAMK2G (see all 7)
        Ras activation uopn Ca2+ infux through NMDA receptor
    Unblocking of NMDA receptor, glutamate binding and activation
    Interferon gamma signaling
    Trafficking of AMPA receptors
    CREB phosphorylation through the activation of CaMKII

    1 PharmGKB Pathway for CAMK2G
        EGFR Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for CAMK2G) (see all 22):
        ErbB signaling pathway
    Calcium signaling pathway
    HIF-1 signaling pathway
    Oocyte meiosis
    Adrenergic signaling in cardiomyocytes


    CAMK2G for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CAMK2G: 
              Circadian Rhythms in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Synaptic Plasticity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CAMK2G

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CAMK2G (Q135551, 3 ENSP000003190604) via UniProtKB, MINT, STRING, and/or I2D (see all 112)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=2 STRING: ENSP00000349467
    CALM2P621583I2D: score=2 
    CALM3P621583I2D: score=2 
    USP19O949663, ENSP000003818634I2D: score=2 STRING: ENSP00000381863
    ACTN4O437073, ENSP000002526994I2D: score=1 STRING: ENSP00000252699
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IEA--
    GO:0006468protein phosphorylation ----
    GO:0006816calcium ion transport IEA--
    GO:0007268synaptic transmission TAS--
    GO:0007399nervous system development IEA--

    CAMK2G for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for CAMK2G available from Tocris Bioscience    About this table
    CompoundAction CAS #
    NH 125CaM kinase III (eEF-2 kinase) inhibitor[278603-08-0]
    STO-609 acetateSelective CaM kinase kinase inhibitor[52029-86-4]
    A 484954CaM kinase III (eEF-2 kinase) inhibitor[142557-61-7]
    KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
    Arcyriaflavin APotent cdk4/cyclin D1 and CaM Kinase II inhibitor. Antiviral agent (anti-HCMV)[118458-54-1]

    2 DrugBank Compounds for CAMK2G    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1-tert-butyl-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine-- --target--10592235
    BosutinibBosulif® (see all 3)380843-75-4targetinhibitor23493838

    Selected Novoseek inferred chemical compound relationships for CAMK2G gene (see all 112)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kn 93 93.4 77 16730662 (4), 10896725 (3), 9517449 (2), 20353560 (2) (see all 46)
    kn62 86.6 28 7588388 (2), 9517449 (2), 8989364 (1), 10919847 (1) (see all 21)
    calcium 82.3 901 16040245 (6), 16608699 (5), 15687337 (5), 14572807 (5) (see all 99)
    syntide-2 82.1 10 8981450 (1), 7836445 (1), 16172120 (1), 12580100 (1) (see all 9)
    calmidazolium 78.6 13 19545622 (2), 9003023 (1), 12193581 (1), 10196527 (1) (see all 11)
    nmda 73 157 9694809 (5), 17602661 (4), 9751209 (4), 8120627 (3) (see all 79)
    glutamate 63.7 87 9032658 (2), 7877986 (2), 15769546 (2), 16337157 (2) (see all 61)
    ionomycin 61.7 29 11129962 (4), 15383398 (3), 7850948 (2), 8770046 (2) (see all 16)
    ryanodine 58.7 16 19883653 (2), 20194790 (2), 10811820 (1), 19342611 (1) (see all 9)
    okadaic acid 58.2 14 19254957 (1), 11129962 (1), 17553505 (1), 10899954 (1) (see all 12)



    CAMK2G for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CAMK2G gene (7 alternative transcripts): 
    NM_001204492.1  NM_001222.3  NM_172169.2  NM_172170.4  NM_172171.2  NM_172173.2  NM_172172.1  

    Unigene Cluster for CAMK2G:

    Calcium/calmodulin-dependent protein kinase II gamma
    Hs.523045  [show with all ESTs]
    Unigene Representative Sequence: AB209474
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000351293 ENST00000322635 ENST00000433289 ENST00000305762 ENST00000372765
    ENST00000441192(uc009xrp.1 uc001jvw.1) ENST00000472912(uc010qkv.2)
    ENST00000474131 ENST00000477205 ENST00000492020 ENST00000477652 ENST00000423381(uc001jvs.2 uc001jvo.2 uc001jvt.2)
    ENST00000322680(uc001jvm.2 uc001jvp.2 uc001jvq.2 uc001jvv.2)
    ENST00000394762(uc001jvr.2 uc001jvx.1) ENST00000444854
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CAMK2G (see all 75):
    hsa-miR-219-5p hsa-miR-371-5p hsa-miR-510 hsa-miR-647 hsa-miR-4289 hsa-miR-4300 hsa-miR-4297 hsa-miR-920
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    GenScript: all cDNA clones in your preferred vector (see all 6): CAMK2G (NM_172169)
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      QuantiFast Probe-based Assays in human, mouse, rat CAMK2G

    Additional mRNA sequence: 

    AB209474.1 AK026309.1 AK131199.1 AK225771.1 AK291704.1 AK301180.1 BC012795.2 BC021269.2 
    BC034044.1 BC037928.1 L07043.1 L07044.1 U32472.1 U32473.1 U32509.1 U50359.1 
    U50360.1 U66063.1 U66064.1 

    Selected DOTS entries (see all 29):

    DT.91752791  DT.444370  DT.99984302  DT.95275517  DT.100885670  DT.100674303  DT.434248  DT.91752790 
    DT.100827661  DT.116882  DT.121239498  DT.121239459  DT.91752787  DT.95180782  DT.100743530  DT.423427 
    DT.95275534  DT.100803750  DT.121239447  DT.121239458  DT.121239494  DT.75134549  DT.75174775  DT.95275521 

    Selected AceView cDNA sequences (see all 388):

    BQ272328 AA305107 BC021269 BU070253 AK026309 BQ933559 NM_172170 AI004351 
    AW239099 BX460288 BX094357 CN479163 BM672879 AI139738 AW614722 BM807023 
    BF222507 BQ267477 BX461065 BQ182120 BE671529 BU728870 NM_172173 AI148471 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CAMK2G (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^
    SP1:                    -                 -                 -     -     -     -                                                           -     -               
    SP2:                                                        -                                                                             -           -     -   
    SP3:                    -     -     -     -                 -                                                                 -           -     -               
    SP4:                                                                                                                          -           -     -               
    SP5:                                                                                                                          -           -     -           -   

    ExUns: 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b · 24c ^ 25a · 25b ^ 26a · 26b
    SP1:  -                             -                 -     -                           
    SP2:  -                 -     -     -                 -     -                           
    SP3:  -                 -     -     -                 -     -                           
    SP4:  -                       -     -                 -     -                           
    SP5:  -                 -     -     -                 -     -                           


    ECgene alternative splicing isoforms for CAMK2G

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CAMK2G expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAACATAGA
    CAMK2G Expression
    About this image


    CAMK2G expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Granulocytes Peripheral Blood
             Peripheral blood-derived hematopoietic stem cells (family)
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Thymus (Hematopoietic System)
             Thymus
    CAMK2G Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CAMK2G Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523045

    UniProtKB/Swiss-Prot: KCC2G_HUMAN, Q13555
    Tissue specificity: Expressed in skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CAMK2G: 
              Circadian Rhythms in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Synaptic Plasticity in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMK2G

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for CAMK2G gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Camk2g1 , 5 calcium/calmodulin-dependent protein kinase II gamma1, 5 94.21(n)1
    99.81(a)1
      14 (11.53 cM)5
    123251  NM_178597.51  NP_848712.21 
     207348755 
    chicken
    (Gallus gallus)
    Aves CAMK2G1 calcium/calmodulin-dependent protein kinase II gamma 82.74(n)
    93.64(a)
      423737  XM_421612.4  XP_421612.4 
    lizard
    (Anolis carolinensis)
    Reptilia CAMK2G6
    calcium/calmodulin-dependent protein kinase II gam...
    82(a)
    1 ↔ 1
    GL343196.1(1538320-1739726)
    African clawed frog
    (Xenopus laevis)
    Amphibia camk2g-prov2 calcium/calmodulin-dependent protein kinase (CaM kinase) more 79.7(n)    AF233632.1 
    zebrafish
    (Danio rerio)
    Actinopterygii camk2g11 calcium/calmodulin-dependent protein kinase (CaM kinase) more 76.56(n)
    87.8(a)
      791855  NM_001030125.1  NP_001025296.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CaMKII6
    Calcium/calmodulin-dependent protein kinase II
    73(a)
    1 → many
    4(1055914-1074329)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-436
    Protein UNC-43, isoform r (unc-43) mRNA, complete ...
    49(a)
    1 → many
    IV(10324317-10350217) WBGene00006779


    ENSEMBL Gene Tree for CAMK2G (if available)
    TreeFam Gene Tree for CAMK2G (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CAMK2G gene
    PNCK2  CAMK1G2  PSKH22  DCX2  DCLK22  CAMK2A2  CAMK1D2  DCLK12  
    PSKH12  CAMK42  CAMK2D2  DCLK32  CAMKV2  CAMK2B2  CAMK12  
    Selected SIMAP similar genes for CAMK2G using alignment to 6 protein entries:     KCC2G_HUMAN (see all proteins) (see all similar genes):
    CAMK2B    CAMK2D    CAMK2A    CDK4    CASK    PNCK
    DCLK3    STK11    PRKAA1    CAMK1D    PHKG2    STK17A
    RPS6KA3    PRKY    PSKH1    DAPK3    MGC45428    PSKH2

    CAMK2G for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for CAMK2G (see all 1619)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1121063251,2
    C,F--75573672(+) GCTGCC/TTCCAC 6 -- ut312Minor allele frequency- T:0.04CSA WA 120
    rs570646931,2
    --75573685(+) CAGGCC/TGGGAG 6 -- ut310--------
    rs23063271,2
    C,F,O,H--75573778(+) AGTTCA/TTTCCT 6 -- ut3119Minor allele frequency- T:0.13NA EA NS CSA WA 2670
    rs1882263401,2
    --75573828(+) CATCAC/TGGCCC 6 -- ut310--------
    rs1810950961,2
    --75573829(+) ATCACA/GGCCCC 6 -- ut310--------
    rs1498310051,2
    --75573831(+) CACGGC/TCCCCA 6 -- ut310--------
    rs1117202831,2
    F--75573913(+) AGGCCG/AGTGGG 6 -- ut311Minor allele frequency- A:0.50CSA 2
    rs2015740411,2
    C--75574018(+) GGATTC/TCTTTT 6 -- ut310--------
    rs110007841,2
    C--75574044(+) TTTTTC/TCTTTT 6 -- ut31 trp30--------
    rs10574101,2
    C,F,H--75574079(-) TGTACC/TGAGGT 6 -- ut31 ese314Minor allele frequency- T:0.12NA NS EA CSA WA 927

    HapMap Linkage Disequilibrium report for CAMK2G (75572259 - 75634349 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CAMK2G:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7154CNV Insertion18451855
    dgv46n21CNV Loss19592680
    esv21502CNV Loss19812545
    nsv825468CNV Gain20364138
    nsv831912CNV Gain17160897

    Human Gene Mutation Database (HGMD): CAMK2G
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602123    OMIM disorders: --

    Selected diseases for CAMK2G (see all 49):    
    About MalaCards
    timothy syndrome    usher syndrome, type 1f    transient cerebral ischemia    tauopathy
    brain ischemia    ischemia    hepatic encephalopathy    usher syndrome
    attention deficit hyperactivity disorder    drug dependence    status epilepticus    hairy cell leukemia
    tetanus    adrenocortical carcinoma    brain disease    brain injury
    cerebritis    temporal lobe epilepsy    cystic fibrosis    papillary thyroid carcinoma


    CAMK2G for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CAMK2G gene (see all 47)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cardiac hypertrophy 44.1 15 15276473 (3), 18056528 (3), 16511595 (1), 16610345 (1) (see all 8)
    heart failure 28.3 30 15276473 (2), 19883653 (2), 16138211 (2), 17704163 (2) (see all 16)
    hypertrophy 27.8 13 20023119 (3), 19207476 (3), 18803570 (1), 19997488 (1) (see all 8)
    alzheimers disease 27.5 6 7820630 (2), 14665412 (1), 17241267 (1), 19536656 (1) (see all 5)
    tauopathies 25.3 2 11810404 (2)
    tetanus 24.1 8 10798500 (2), 10479685 (1), 19450629 (1), 9204925 (1) (see all 5)
    neurofibrillary tangles 22.9 2 2120043 (1), 7820630 (1)
    transient cerebral ischemia 19 1 1331917 (1)
    arrhythmia 18.2 30 18803570 (3), 17254559 (3), 19333131 (2), 19997488 (2) (see all 12)
    myeloid leukemia 10.9 5 17431504 (2), 11376870 (1), 17644368 (1), 19388154 (1)

    Genetic Association Database (GAD): CAMK2G
    Human Genome Epidemiology (HuGE) Navigator: CAMK2G (7 documents)

    Export disorders for CAMK2G gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for CAMK2G gene, integrated from 10 sources (see all 862):
    (articles sorted by number of sources associating them with CAMK2G)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of novel human tumor cell-specific CaMK-II variants. (PubMed id 9060999)1, 2, 9 Tombes R.M. and Krystal G.W. (Biochim. Biophys. Acta 1997)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PubMed id 19204726)1, 4 Chapuis J....Lambert J.C. (Mol. Psychiatry 2009)
    4. Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease. (PubMed id 17373700)1, 4 Morgan A.R....Williams J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
    5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    6. Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+- calmodulin-dependent protein kinase II. (PubMed id 14722083)1, 2 Gaertner T.R.... Waxham M.N. (J. Biol. Chem. 2004)
    7. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    8. The role of calcium and calcium/calmodulin-dependent kinases in skeletal muscle plasticity and mitochondrial biogenesis. (PubMed id 15294044)1, 2 Chin E.R. (Proc. Nutrit. Soc. 2004)
    9. Human calcium/calmodulin-dependent protein kinase II gamma: cloning, genomic structure and detection of variants in subjects with type II diabetes. (PubMed id 12032636)1, 2 Gloyn A.L.... Ashcroft S.J. (Diabetologia 2002)
    10. Human islets of Langerhans express multiple isoforms of calcium/calmodulin-dependent protein kinase II. (PubMed id 9240463)1, 2 Breen M.A. and Ashcroft S.J. (Biochem. Biophys. Res. Commun. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 818 HGNC: 1463 AceView: CAMK2G Ensembl:ENSG00000148660 euGenes: HUgn818
    ECgene: CAMK2G Kegg: 818 H-InvDB: CAMK2G

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CAMK2G Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CAMK2G gene:
    Search GeneIP for patents involving CAMK2G

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     ThermoFisher Antibodies for CAMK2G
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMK2G
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CAMK2G
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CAMK2G
     LSBio Antibodies in human, mouse, rat for CAMK2G
    Customized transgenic rodents for:
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     Tissue-specific gene expresssion
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