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Aliases for CAMK2G Gene

Aliases for CAMK2G Gene

  • Calcium/Calmodulin Dependent Protein Kinase II Gamma 2 3
  • Calcium/Calmodulin-Dependent Protein Kinase (CaM Kinase) II Gamma 2 3
  • Calcium/Calmodulin-Dependent Protein Kinase II Gamma 3 5
  • CaMK-II Subunit Gamma 3 4
  • EC 2.7.11.17 4 63
  • CAMK-II 3 4
  • CAMKG 3 4
  • CAMK 3 4
  • CaM Kinase II Subunit Gamma 4
  • EC 2.7.11 63

External Ids for CAMK2G Gene

Previous HGNC Symbols for CAMK2G Gene

  • CAMKG

Previous GeneCards Identifiers for CAMK2G Gene

  • GC10M074352
  • GC10M074675
  • GC10M075464
  • GC10M074916
  • GC10M075242
  • GC10M075572
  • GC10M069567

Summaries for CAMK2G Gene

Entrez Gene Summary for CAMK2G Gene

  • The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined.[provided by RefSeq, Mar 2011]

GeneCards Summary for CAMK2G Gene

CAMK2G (Calcium/Calmodulin Dependent Protein Kinase II Gamma) is a Protein Coding gene. Diseases associated with CAMK2G include usher syndrome, type 1f and timothy syndrome. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is CAMK2D.

UniProtKB/Swiss-Prot for CAMK2G Gene

  • Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplsamic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning.

Tocris Summary for CAMK2G Gene

  • Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through autoinhibition, which can be relieved by increases in Ca2+ levels.

Gene Wiki entry for CAMK2G Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMK2G Gene

Genomics for CAMK2G Gene

Regulatory Elements for CAMK2G Gene

Promoters for CAMK2G Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CAMK2G on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CAMK2G gene promoter:

Genomic Location for CAMK2G Gene

Chromosome:
10
Start:
73,812,501 bp from pter
End:
73,874,591 bp from pter
Size:
62,091 bases
Orientation:
Minus strand

Genomic View for CAMK2G Gene

Genes around CAMK2G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAMK2G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAMK2G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMK2G Gene

Proteins for CAMK2G Gene

  • Protein details for CAMK2G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13555-KCC2G_HUMAN
    Recommended name:
    Calcium/calmodulin-dependent protein kinase type II subunit gamma
    Protein Accession:
    Q13555
    Secondary Accessions:
    • O00561
    • O15378
    • Q13279
    • Q13282
    • Q13556
    • Q5SQZ3
    • Q5SQZ4
    • Q5SWX4
    • Q7KYX5
    • Q8N4I3
    • Q8NIA4

    Protein attributes for CAMK2G Gene

    Size:
    558 amino acids
    Molecular mass:
    62609 Da
    Quaternary structure:
    • CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other.
    SequenceCaution:
    • Sequence=AAB61379.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CAMK2G Gene

    Alternative splice isoforms for CAMK2G Gene

neXtProt entry for CAMK2G Gene

Proteomics data for CAMK2G Gene at MOPED

Post-translational modifications for CAMK2G Gene

  • Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for CAMK2G (CaM Kinase II gamma)
  • Cell Signaling Technology (CST) Antibodies for CAMK2G (CAMK2G)
  • Cloud-Clone Corp. Antibodies for CAMK2G

Domains & Families for CAMK2G Gene

Graphical View of Domain Structure for InterPro Entry

Q13555

UniProtKB/Swiss-Prot:

KCC2G_HUMAN :
  • The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Domain:
  • The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
genes like me logo Genes that share domains with CAMK2G: view

Function for CAMK2G Gene

Molecular function for CAMK2G Gene

GENATLAS Biochemistry:
protein kinase,calcium/calmodulin dependent,gammasubunit with several isoforms
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity.
UniProtKB/Swiss-Prot Function:
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplsamic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning.
UniProtKB/Swiss-Prot Induction:
Activity is induced in skeletal muscle during exercise.

Enzyme Numbers (IUBMB) for CAMK2G Gene

Gene Ontology (GO) - Molecular Function for CAMK2G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
genes like me logo Genes that share ontologies with CAMK2G: view
genes like me logo Genes that share phenotypes with CAMK2G: view

Animal Models for CAMK2G Gene

MGI Knock Outs for CAMK2G:

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAMK2G Gene

Localization for CAMK2G Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMK2G Gene

Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAMK2G Gene COMPARTMENTS Subcellular localization image for CAMK2G gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 5
endoplasmic reticulum 4
cytoskeleton 2
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for CAMK2G Gene

Pathways & Interactions for CAMK2G Gene

SuperPathways for CAMK2G Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Post NMDA receptor activation events
3 Development Angiotensin activation of ERK
4 Development Endothelin-1/EDNRA signaling
5 Cardiac conduction
genes like me logo Genes that share pathways with CAMK2G: view

SIGNOR curated interactions for CAMK2G Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for CAMK2G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IEA --
GO:0000186 activation of MAPKK activity TAS --
GO:0006468 protein phosphorylation IEA --
GO:0006470 protein dephosphorylation NAS 9060999
GO:0006816 calcium ion transport IEA --
genes like me logo Genes that share ontologies with CAMK2G: view

Drugs & Compounds for CAMK2G Gene

(68) Drugs for CAMK2G Gene - From: Novoseek, Tocris, DrugBank, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
bosutinib Approved Pharma Target, inhibitor Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors, Dual Src-Abl inhibitor; antiproliferative 0
Bosulif Approved September 2012 Pharma 0
1-tert-butyl-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Experimental Pharma Target 0
KN-62 Pharma CaM kinase II inhibitor, Non-competitive P2X7 antagonist 0

(51) Additional Compounds for CAMK2G Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
KN 93
139298-40-1
Arcyriaflavin A
118458-54-1
Autocamtide-2-related inhibitory peptide
167114-91-2
STO-609 acetate
1173022-21-3

(5) Tocris Compounds for CAMK2G Gene

Compound Action Cas Number
Arcyriaflavin A Potent cdk4/cyclin D1 and CaM Kinase II inhibitor. Antiviral agent (anti-HCMV) 118458-54-1
Autocamtide-2-related inhibitory peptide Selective CaM kinase II inhibitor 167114-91-2
KN 93 CaM kinase II inhibitor; also K+ channel blocker (KV) 139298-40-1
KN-62 Non-competitive P2X7 antagonist 127191-97-3
STO-609 acetate Selective CaM kinase kinase inhibitor 1173022-21-3
genes like me logo Genes that share compounds with CAMK2G: view

Transcripts for CAMK2G Gene

Unigene Clusters for CAMK2G Gene

Calcium/calmodulin-dependent protein kinase II gamma:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAMK2G Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^
SP1: - - - - - - - -
SP2: - - - -
SP3: - - - - - - - -
SP4: - - -
SP5: - - - -
SP6:
SP7:
SP8: - -
SP9: -
SP10: - -
SP11:

ExUns: 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b · 24c ^ 25a · 25b ^ 26a · 26b
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for CAMK2G Gene

GeneLoc Exon Structure for
CAMK2G
ECgene alternative splicing isoforms for
CAMK2G

Expression for CAMK2G Gene

mRNA expression in normal human tissues for CAMK2G Gene

Protein differential expression in normal tissues from HIPED for CAMK2G Gene

This gene is overexpressed in Brain (20.4), Heart (7.1), Frontal cortex (7.0), and Adrenal (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAMK2G Gene



SOURCE GeneReport for Unigene cluster for CAMK2G Gene Hs.523045

mRNA Expression by UniProt/SwissProt for CAMK2G Gene

Q13555-KCC2G_HUMAN
Tissue specificity: Expressed in skeletal muscle.
genes like me logo Genes that share expression patterns with CAMK2G: view

Protein tissue co-expression partners for CAMK2G Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CAMK2G Gene

Orthologs for CAMK2G Gene

This gene was present in the common ancestor of animals.

Orthologs for CAMK2G Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CAMK2G 35
  • 95.49 (n)
  • 99.8 (a)
CAMK2G 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAMK2G 35
  • 95.74 (n)
  • 99.82 (a)
CAMK2G 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Camk2g 35
  • 94.21 (n)
  • 99.81 (a)
Camk2g 16
Camk2g 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CAMK2G 35
  • 99.77 (n)
  • 100 (a)
CAMK2G 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Camk2g 35
  • 92.95 (n)
  • 97.83 (a)
oppossum
(Monodelphis domestica)
Mammalia CAMK2G 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAMK2G 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves CAMK2G 35
  • 82.74 (n)
  • 93.64 (a)
CAMK2G 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAMK2G 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia camk2g 35
  • 81.04 (n)
  • 96.13 (a)
Str.15647 35
African clawed frog
(Xenopus laevis)
Amphibia camk2g-prov 35
zebrafish
(Danio rerio)
Actinopterygii camk2g1 35
  • 76.56 (n)
  • 87.8 (a)
CAMK2G (1 of 2) 36
  • 72 (a)
OneToMany
camk2g1 36
  • 86 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5109 35
fruit fly
(Drosophila melanogaster)
Insecta CaMKII 36
  • 73 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-43 36
  • 49 (a)
OneToMany
Species with no ortholog for CAMK2G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAMK2G Gene

ENSEMBL:
Gene Tree for CAMK2G (if available)
TreeFam:
Gene Tree for CAMK2G (if available)

Paralogs for CAMK2G Gene

genes like me logo Genes that share paralogs with CAMK2G: view

Variants for CAMK2G Gene

Sequence variations from dbSNP and Humsavar for CAMK2G Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs17853266 - 73,873,043(+) CGTGG(A/G)GGTTT nc-transcript-variant, reference, missense, utr-variant-5-prime
VAR_069390 -
rs1057410 -- 73,814,321(-) TGTAC(C/T)GAGGT nc-transcript-variant, utr-variant-3-prime
rs1272655 -- 73,837,765(+) GAGAA(A/G)CCATG intron-variant
rs2242253 -- 73,825,089(+) CCATG(C/T)GGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAMK2G Gene

Variant ID Type Subtype PubMed ID
nsv831912 CNV Gain 17160897
nsv825468 CNV Gain 20364138
dgv46n21 CNV Loss 19592680
nsv7154 CNV Insertion 18451855
esv21502 CNV Loss 19812545

Variation tolerance for CAMK2G Gene

Residual Variation Intolerance Score: 10.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAMK2G Gene

HapMap Linkage Disequilibrium report
CAMK2G
Human Gene Mutation Database (HGMD)
CAMK2G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMK2G Gene

Disorders for CAMK2G Gene

MalaCards: The human disease database

(7) MalaCards diseases for CAMK2G Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
usher syndrome, type 1f
  • ush1f
timothy syndrome
  • long qt syndrome with syndactyly
occlusion precerebral artery
  • occlusion and stenosis of multiple and bilateral precerebral arteries
carotid artery occlusion
  • occlusion and stenosis of carotid artery
ischemia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CAMK2G

Genetic Association Database (GAD)
CAMK2G
Human Genome Epidemiology (HuGE) Navigator
CAMK2G
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAMK2G
genes like me logo Genes that share disorders with CAMK2G: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAMK2G Gene

Publications for CAMK2G Gene

  1. Identification of novel human tumor cell-specific CaMK-II variants. (PMID: 9060999) Tombes R.M. … Krystal G.W. (Biochim. Biophys. Acta 1997) 3 4 23 67
  2. Regulation of CaMKII by phospho-Thr253 or phospho-Thr286 sensitive targeting alters cellular function. (PMID: 20060891) Skelding K.A. … Rostas J.A. (Cell. Signal. 2010) 3 23
  3. Molecular interaction and functional regulation of ClC-3 by Ca2+/calmodulin-dependent protein kinase II (CaMKII) in human malignant glioma. (PMID: 20139089) Cuddapah V.A. … Sontheimer H. (J. Biol. Chem. 2010) 3 23
  4. Differential regulation by ATP versus ADP further links CaMKII aggregation to ischemic conditions. (PMID: 19840793) Vest R.S. … Bayer K.U. (FEBS Lett. 2009) 3 23
  5. Calcium/calmodulin-dependent protein kinase II (CaMKII) regulates tumour necrosis factor-related apoptosis inducing ligand (TRAIL)-mediated apoptosis of fibroblast-like synovial cells (FLS) by phosphorylation of Akt. (PMID: 20149311) Fujikawa K. … Eguchi K. (Clin. Exp. Rheumatol. 2009) 3 23

Products for CAMK2G Gene

Sources for CAMK2G Gene

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