Aliases for CAMK2G Gene
Aliases for CAMK2G Gene
External Ids for CAMK2G Gene
- HGNC: 1463
- Entrez Gene: 818
- Ensembl: ENSG00000148660
- OMIM: 602123
- UniProtKB: Q13555
Previous HGNC Symbols for CAMK2G Gene
- CAMKG
Previous GeneCards Identifiers for CAMK2G Gene
- GC10M074352
- GC10M074675
- GC10M075464
- GC10M074916
- GC10M075242
- GC10M075572
- GC10M069567
Summaries for CAMK2G Gene
-
The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined.[provided by RefSeq, Mar 2011]
GeneCards Summary for CAMK2G Gene
CAMK2G (Calcium/Calmodulin Dependent Protein Kinase II Gamma) is a Protein Coding gene. Diseases associated with CAMK2G include Timothy Syndrome and Exudative Vitreoretinopathy. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and Development Endothelin-1/EDNRA signaling. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is CAMK2B.
UniProtKB/Swiss-Prot for CAMK2G Gene
-
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplsamic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning.
-
Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through autoinhibition, which can be relieved by increases in Ca2+ levels.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMK2G Gene
Genomics for CAMK2G Gene
Regulatory Elements for CAMK2G Gene
Enhancers for CAMK2G Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CAMK2G on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CAMK2G gene promoter:
Regulatory Element Products
Genomic Location for CAMK2G Gene
- Chromosome:
- 10
- Start:
- 73,812,501 bp from pter
- End:
- 73,874,591 bp from pter
- Size:
- 62,091 bases
- Orientation:
- Minus strand
Genomic View for CAMK2G Gene
Genes around CAMK2G on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q22.2 by Ensembl
- 10q22.2 by Entrez Gene
- 10q22.2 by HGNC
CAMK2G Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CAMK2G Gene
Proteins for CAMK2G Gene
-
Protein details for CAMK2G Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13555-KCC2G_HUMAN
- Recommended name:
- Calcium/calmodulin-dependent protein kinase type II subunit gamma
- Protein Accession:
- Q13555
- O00561
- O15378
- Q13279
- Q13282
- Q13556
- Q5SQZ3
- Q5SQZ4
- Q5SWX4
- Q7KYX5
- Q8N4I3
- Q8NIA4
Protein attributes for CAMK2G Gene
- Size:
- 558 amino acids
- Molecular mass:
- 62609 Da
- Quaternary structure:
-
- CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other.
- SequenceCaution:
-
- Sequence=AAB61379.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for CAMK2G Gene
Selected DME Specific Peptides for CAMK2G Gene
- Q13555:
-
- WACGVILYILLVGYPPFWDEDQH
- TVASMMHRQETV
- YTKICDP
- NNGDFEAY
- KGAAVKLADFGLAIEV
- NIVRLHD
- YGKPVDIWA
- HYLVFDLVTGGELFEDIVARE
- GVILYIL
- FPSPEWD
- RNFSAAKSLL
- QAWFGFAGTPGYLSPEVL
- WACGVIL
- LIEAINNG
- FEPEALGNLVEG
- QILESVNH
- VHRDLKPENLLLASK
- VKLADFG
- VTGGELF
- GVKKRKSSSSV
- TEQLIEA
- MLTINPAKRI
- QIKAGAYD
- PYGKPVD
- PSPEWDTVTPEAKNLINQMLT
- LADFGLA
- QSEETRVWH
- DFHKFYFEN
- DAACIAYIRLTQY
- RKQEIIK
- LKPENLL
- RDLKPEN
- GKGAFSVVRRC
- AAKIINTKKL
- TCTRFTD
- EELGKGAFS
- FNARRKL
- NIVRLHDSISEEG
- QKLEREARICR
- VHRDLKP
- IVHRDLK
Post-translational modifications for CAMK2G Gene
- Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for CAMK2G Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- NP_001191421.1
- NP_001213.2
- NP_001307827.1
- NP_751909.1
- NP_751910.1
- NP_751911.1
- NP_751913.1
- XP_005270252.1
- XP_005270254.1
- XP_005270255.1
- XP_005270256.1
- XP_005270257.1
- XP_005270258.1
- XP_005270260.1
- XP_005270262.1
- XP_006718056.1
- XP_006718059.1
- XP_006718060.1
- XP_006718061.1
- XP_011538527.1
- XP_016872205.1
- XP_016872206.1
- XP_016872207.1
- XP_016872208.1
- XP_016872209.1
- XP_016872210.1
- XP_016872211.1
- XP_016872212.1
- XP_016872213.1
- XP_016872214.1
- XP_016872215.1
- XP_016872216.1
- XP_016872217.1
- XP_016872218.1
- XP_016872219.1
- XP_016872220.1
- XP_016872221.1
- XP_016872222.1
- XP_016872223.1
- XP_016872224.1
- XP_016872225.1
- XP_016872226.1
- XP_016872227.1
- XP_016872228.1
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CAMK2G
- R&D Systems Antibodies for CAMK2G (CaM Kinase II gamma)
- Cell Signaling Technology (CST) Antibodies for CAMK2G (CAMK2G)
-
Custom Antibody ServicesOriGene Antibodies for CAMK2G
- Novus Biologicals Antibodies for CAMK2G
-
Abcam antibodies for CAMK2G
-
Cloud-Clone Corp. Antibodies for CAMK2G
- Invitrogen Antibodies for CAMK2G
- antibodies-online Antibodies for CAMK2G: See all 139
- GeneTex CAMK2G antibody for CAMK2G
-
Santa Cruz Biotechnology (SCBT) Antibodies for CAMK2G
Protein Products
- EMD Millipore Purified and/or Recombinant CAMK2G Protein
- Search Origene for MassSpec and Protein Over-expression Lysates for CAMK2G
- Origene Custom Protein Services for CAMK2G
-
Cloud-Clone Corp. Proteins for CAMK2G
- antibodies-online Proteins for CAMK2G: See all 10
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CAMK2G
-
Abcam proteins for CAMK2G
Assay Products
- antibodies-online Kits for CAMK2G: See all 4
Domains & Families for CAMK2G Gene
Gene Families for CAMK2G Gene
Protein Domains for CAMK2G Gene
Suggested Antigen Peptide Sequences for CAMK2G Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ38257 fis, clone FCBBF3001235, highly similar to Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (B3KTH7_HUMAN)
- cDNA FLJ52939, moderately similar to Calcium/calmodulin-dependent protein kinasetype II gamma chain (EC 2.7.11.17) (B4DVQ3_HUMAN)
- Calcium/calmodulin-dependent protein kinase type II subunit gamma (KCC2G_HUMAN)
- Calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma (Q8WU40_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q13555UniProtKB/Swiss-Prot:
KCC2G_HUMAN :- The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.
- Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
- Domain:
-
- The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.
- Family:
-
- Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Function for CAMK2G Gene
Molecular function for CAMK2G Gene
- GENATLAS Biochemistry:
- protein kinase,calcium/calmodulin dependent,gammasubunit with several isoforms
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity.
- UniProtKB/Swiss-Prot Function:
- Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplsamic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning.
- UniProtKB/Swiss-Prot Induction:
- Activity is induced in skeletal muscle during exercise.
Enzyme Numbers (IUBMB) for CAMK2G Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IEA,TAS | -- |
| GO:0004683 | calmodulin-dependent protein kinase activity | IBA,IEA | -- |
| GO:0004723 | calcium-dependent protein serine/threonine phosphatase activity | NAS | 9060999 |
Phenotypes for CAMK2G Gene
- MGI mutant phenotypes for CAMK2G:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CAMK2G:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Increased transferrin (TF) endocytosis
- Decreased shRNA abundance (Z-score < -2)
- Increased G1 DNA content
- Increased shRNA abundance (Z-score > 2)
- Decreased viability
- Decreased cell migration
- Synthetic lethal with imatinib mesylate
- Decreased viability of wild-type and TP53 knockout cells
- Decreased substrate adherent cell growth
- Decreased Hepatitis C Virus pseudoparticles (HCVpp
- Decreased telomerase activity
- Paclitaxel antagonistic effect
- Decreased Cdk9 T-loop phosphorylation
Animal Models for CAMK2G Gene
- MGI Knock Outs for CAMK2G:
-
- Camk2g tm1.1Irt
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CAMK2G
-
- Search ViGene Biosciences for CAMK2G
CRISPR Products
-
OriGene CRISPR knockouts for CAMK2G
-
Santa Cruz Biotechnology (SCBT) CRISPR for CAMK2G
- GenScript: Design CRISPR guide RNA sequences for CAMK2G
miRNA for CAMK2G Gene
- miRTarBase miRNAs that target CAMK2G
-
- hsa-mir-219a-5p (MIRT004446)
- hsa-mir-1-3p (MIRT024052)
- hsa-mir-16-5p (MIRT031976)
- hsa-mir-331-3p (MIRT043311)
- hsa-mir-1268a (MIRT053737)
- hsa-mir-6809-3p (MIRT659897)
- hsa-mir-5006-3p (MIRT659898)
- hsa-mir-4755-5p (MIRT659899)
- hsa-mir-4753-3p (MIRT659900)
- hsa-mir-211-5p (MIRT659901)
- hsa-mir-204-5p (MIRT659902)
- hsa-mir-623 (MIRT659903)
- hsa-mir-5088-3p (MIRT659904)
- hsa-mir-4704-5p (MIRT659905)
- hsa-mir-5571-5p (MIRT659906)
- hsa-mir-6749-3p (MIRT720322)
- hsa-mir-3156-3p (MIRT720323)
- hsa-mir-2116-3p (MIRT720324)
- hsa-mir-532-3p (MIRT720325)
- hsa-mir-4301 (MIRT720326)
- hsa-mir-1273g-3p (MIRT720327)
- hsa-mir-6890-3p (MIRT720328)
- hsa-mir-483-3p (MIRT720329)
miRNA Products
- Search ViGene Biosciences for CAMK2G
Inhibitory RNA Products
- Origene shRNA, RNAi, and siRNA products in human, mouse, rat for CAMK2G
- Browse OriGene Inhibitory RNA Products For CAMK2G
Clone Products
-
OriGene ORF clones in human for CAMK2G
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
-
GenScript: Next-day shipping cDNA ORF clone for CAMK2G in any vector
- XM_006717993
- XM_011540224
- XM_005270195
- XM_011540225
- XM_006717995
- XM_006717996
- XM_011540226
- XM_005270197
- XM_005270198
- XM_011540227
- XM_005270199
- XM_006717997
- XM_005270200
- XM_005270201
- XM_006717998
- XM_005270202
- XM_005270203
- NM_172173
- NM_172171
- NM_172170
- NM_172169
- NM_001222
- NM_001204492
- XM_006718000
- XM_011540231
- XM_011540230
- XM_011540229
- XM_011540228
- XM_006717999
- XM_005270205
- Sino Biological Human cDNA Clone for CAMK2G
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CAMK2G
- VectorBuilder custom plasmid, inducible vectors for CAMK2G
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CAMK2G
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CAMK2G
Flow Cytometry Products
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAMK2G Gene
Localization for CAMK2G Gene
Subcellular locations from UniProtKB/Swiss-Prot for CAMK2G Gene
- Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| cytosol | 5 |
| endoplasmic reticulum | 4 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IBA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0014069 | postsynaptic density | IEA | -- |
Pathways & Interactions for CAMK2G Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Post NMDA receptor activation events | ||
| 3 | Development Angiotensin activation of ERK | ||
| 4 | Development Endothelin-1/EDNRA signaling | ||
| 5 | Cardiac conduction |
.39
|
|
Pathways by source for CAMK2G Gene
4 Sino Biological pathways for CAMK2G Gene
1 GeneTex pathway for CAMK2G Gene
2 Cell Signaling Technology pathways for CAMK2G Gene
5 BioSystems pathways for CAMK2G Gene
69 Reactome pathways for CAMK2G Gene
1 PharmGKB pathway for CAMK2G Gene
26 KEGG pathways for CAMK2G Gene
18 GeneGo (Thomson Reuters) pathways for CAMK2G Gene
3 R&D Systems pathways for CAMK2G Gene
18 Qiagen pathways for CAMK2G Gene
Interacting Proteins for CAMK2G Gene
Selected Interacting proteins:
ENSP00000319060
Q13555-KCC2G_HUMAN
for CAMK2G Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | IEA | -- |
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0006470 | protein dephosphorylation | IEA | -- |
| GO:0006816 | calcium ion transport | IEA | -- |
Drugs & Compounds for CAMK2G Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| bosutinib | Approved | Pharma | Target, inhibitor | Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors | 0 | |
| Bosulif | Approved September 2012 | Pharma | 0 | |||
| 1-tert-butyl-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Experimental | Pharma | Target | 0 | ||
| KN-93 Phosphate | Pharma | CaM kinase II inhibitor, water soluble and cell permeable, CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278). | 0 | |||
| Autocamtide-2-related inhibitory peptide | Pharma | inhibitor of calmodulin-dependent protein kinase II (CaM-kinase II, CaMKII) | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| KN 93 |
|
139298-40-1 |
|
|||
| Autocamtide-2-related inhibitory peptide, myristoylated |
|
201422-04-0 |
|
|
(5) Tocris Compounds for CAMK2G Gene
| Compound | Action | Cas Number |
|---|---|---|
| A 484954 | CaM kinase III (eEF-2 kinase) inhibitor | 142557-61-7 |
| Autocamtide-2-related inhibitory peptide, myristoylated | CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptide | 201422-04-0 |
| KN 93 | CaM kinase II inhibitor; also K+ channel blocker (KV) | 139298-40-1 |
| KN 93 phosphate | CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278). | 1188890-41-6 |
| STO-609 acetate | Selective CaM kinase kinase inhibitor | 1173022-21-3 |
(8) ApexBio Compounds for CAMK2G Gene
| Compound | Action | Cas Number |
|---|---|---|
| Autocamtide-2-related inhibitory peptide | inhibitor of calmodulin-dependent protein kinase II (CaM-kinase II, CaMKII) | 167114-91-2 |
| CaMKII-IN-1 | 1208123-85-6 | |
| KN-62 | CaM kinase II inhibitor | 127191-97-3 |
| KN-92 | CaMKII inhibitor | 176708-42-2 |
| KN-92 phosphate | CaMKII inhibitor | 1135280-28-2 |
| KN-93 | CaMKII inhibitor,selective and cometitive | 139298-40-1 |
| KN-93 hydrochloride | CaMK II inhibitor | |
| KN-93 Phosphate | CaM kinase II inhibitor, water soluble and cell permeable | 1188890-41-6 |
Drug Products
- ApexBio compounds for CAMK2G
Transcripts for CAMK2G Gene
mRNA/cDNA for CAMK2G Gene
- (45) REFSEQ mRNAs :
- (19) Additional mRNA sequences :
- (388) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CAMK2G Gene
CRISPR Products
-
OriGene CRISPR knockouts for CAMK2G
-
Santa Cruz Biotechnology (SCBT) CRISPR for CAMK2G
- GenScript: Design CRISPR guide RNA sequences for CAMK2G
miRNA Products
- Search ViGene Biosciences for CAMK2G
Inhibitory RNA Products
- Origene shRNA, RNAi, and siRNA products in human, mouse, rat for CAMK2G
- Browse OriGene Inhibitory RNA Products For CAMK2G
Clone Products
-
OriGene ORF clones in human for CAMK2G
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
-
GenScript: Next-day shipping cDNA ORF clone for CAMK2G in any vector
- XM_006717993
- XM_011540224
- XM_005270195
- XM_011540225
- XM_006717995
- XM_006717996
- XM_011540226
- XM_005270197
- XM_005270198
- XM_011540227
- XM_005270199
- XM_006717997
- XM_005270200
- XM_005270201
- XM_006717998
- XM_005270202
- XM_005270203
- NM_172173
- NM_172171
- NM_172170
- NM_172169
- NM_001222
- NM_001204492
- XM_006718000
- XM_011540231
- XM_011540230
- XM_011540229
- XM_011540228
- XM_006717999
- XM_005270205
- Sino Biological Human cDNA Clone for CAMK2G
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CAMK2G
- VectorBuilder custom plasmid, inducible vectors for CAMK2G
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CAMK2G
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: |
| ExUns: | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | ^ | 24a | · | 24b | · | 24c | ^ | 25a | · | 25b | ^ | 26a | · | 26b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | |||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||
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Expression for CAMK2G Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Blood (Hematopoietic System)
- Thymus (Hematopoietic System)
This gene is overexpressed in Brain (20.4), Heart (7.1), Frontal cortex (7.0), and Adrenal (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CAMK2G Gene
NURSA nuclear receptor signaling pathways regulating expression of CAMK2G Gene:
CAMK2GSOURCE GeneReport for Unigene cluster for CAMK2G Gene:
Hs.523045mRNA Expression by UniProt/SwissProt for CAMK2G Gene:
Q13555-KCC2G_HUMAN
Tissue specificity:
Expressed in skeletal muscle.
Evidence on tissue expression from TISSUES for CAMK2G Gene
- Nervous system(5)
- Liver(4.1)
- Eye(2.6)
- Lung(2.3)
- Pancreas(2.2)
- Intestine(2.1)
Primer Products
-
OriGene qPCR primer pairs for CAMK2G
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAMK2G Gene
Orthologs for CAMK2G Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CAMK2G 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CAMK2G 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CAMK2G 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | CAMK2G 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Camk2g 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Camk2g 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CAMK2G 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CAMK2G 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CAMK2G 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | camk2g 34 |
|
||
| Str.15647 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | camk2g-prov 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | camk2g1 34 35 |
|
||
| CAMK2G (1 of 2) 35 |
|
OneToMany | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.5109 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CaMKII 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | unc-43 35 |
|
OneToMany |
- Species where no ortholog for CAMK2G was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CAMK2G Gene
Paralogs for CAMK2G Gene
(49) SIMAP similar genes for CAMK2G Gene using alignment to 6 proteins:
- CAMK2B
- CAMK2D
- CAMK2A
- CDK4
- CASK
- PNCK
- DCLK3
- STK11
- PRKAA1
- CAMK1D
- PHKG2
- STK17A
- RPS6KA3
- PRKY
- PSKH1
- RPS6KA1
- PSKH2
- DAPK3
- MGC45428
- CAMK1
- PHKG1
- MYO3A
- PRKX
- STK17B
- TRIB1
- KIN27
- DAPK2
- PAK4
- CAMK1G
- PRKACB
- NUAK1
- MAPKAPK2
- CAMK4
- DCLK2
- MAPKAPK3
- PRKD1
- PRKACG
- NEK6
- MKNK2
- AURKB
- TSSK3
- AURKC
- RPS6KA2
- PRKACA
- DKFZp586A1021
- CAMKV
- MARK4
- CDK1
- TSSK6
Variants for CAMK2G Gene
| SNP ID | Clin | Chr 10 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs397514627 | Uncertain significance | 73,842,486(-) | TTTGC(C/G/T)CAAGT | nc-transcript-variant, reference, missense | |
| rs1000002170 | -- | 73,837,405(+) | TGCCA(A/G)GAATT | intron-variant | |
| rs1000068579 | -- | 73,842,221(+) | GGAAA(C/G)AGGAA | intron-variant | |
| rs1000089106 | -- | 73,841,322(+) | GGGGG(C/G)GTCTT | intron-variant | |
| rs1000185058 | -- | 73,817,772(+) | CCCAG(A/C)CATTA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1264n54 | CNV | loss | 21841781 |
| dgv46n21 | CNV | loss | 19592680 |
| dgv479n106 | CNV | deletion | 24896259 |
| esv21502 | CNV | loss | 19812545 |
| nsv1035634 | CNV | gain | 25217958 |
| nsv1070876 | CNV | deletion | 25765185 |
| nsv1145470 | CNV | deletion | 24896259 |
| nsv551516 | CNV | loss | 21841781 |
| nsv551517 | CNV | loss | 21841781 |
| nsv551518 | CNV | loss | 21841781 |
| nsv551521 | CNV | gain | 21841781 |
| nsv551523 | CNV | loss | 21841781 |
| nsv551526 | CNV | loss | 21841781 |
| nsv7154 | CNV | insertion | 18451855 |
| nsv825468 | CNV | gain | 20364138 |
| nsv831912 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
10.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.54;
11.64% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CAMK2G Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMK2G Gene
Disorders for CAMK2G Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| timothy syndrome |
|
|
| exudative vitreoretinopathy |
|
|
| fibrillary astrocytoma |
|
|
Search CAMK2G in MalaCards
View complete list of genes associated with diseases
Relevant External Links for CAMK2G
No data available for UniProtKB/Swiss-Prot and Genatlas for CAMK2G Gene
Publications for CAMK2G Gene
- Identification of novel human tumor cell-specific CaMK-II variants. (PMID: 9060999) Tombes R.M. … Krystal G.W. (Biochim. Biophys. Acta 1997) 3 4 22 64
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
- Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation. (PMID: 20668654) Rellos P. … Knapp S. (PLoS Biol. 2010) 3 4 64
- Molecular interaction and functional regulation of ClC-3 by Ca2+/calmodulin-dependent protein kinase II (CaMKII) in human malignant glioma. (PMID: 20139089) Cuddapah V.A. … Sontheimer H. (J. Biol. Chem. 2010) 3 22 64
- Regulation of CaMKII by phospho-Thr253 or phospho-Thr286 sensitive targeting alters cellular function. (PMID: 20060891) Skelding K.A. … Rostas J.A. (Cell. Signal. 2010) 3 22 64
Products for CAMK2G Gene
- Browse Small Molecules at EMD Millipore
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CAMK2G
- EMD Millipore Purified and/or Recombinant CAMK2G Protein
- Browse Kits and Assays available from EMD Millipore
- EMD Millipore genomic analysis products
- R&D Systems Antibodies for CAMK2G (CaM Kinase II gamma)
- Browse R&D Systems for Human Recombinant Proteins
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- Browse OriGene ELISA Kits
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for CAMK2G in any vector
- XM_006717993
- XM_011540224
- XM_005270195
- XM_011540225
- XM_006717995
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- XM_006717999
- XM_011540228
- XM_011540229
- XM_011540230
- XM_011540231
- XM_006718000
- NM_001204492
- NM_001222
- NM_172169
- NM_172170
- NM_172171
- NM_172173
- GenScript Custom Purified and Recombinant Proteins Services for CAMK2G
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- Cell Signaling Technology (CST) Antibodies for CAMK2G (CAMK2G)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for CAMK2G
- Browse Sino Biological Cell Lysates
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- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for CAMK2G
- Novus Biologicals proteins and lysates for CAMK2G
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for CAMK2G
- Abcam proteins for CAMK2G
- Search for Assays for CAMK2G at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Cloud-Clone Corp. Antibodies for CAMK2G
- Cloud-Clone Corp. Proteins for CAMK2G
- Browse Assay Kits at Cloud-Clone Corp.
- Invitrogen Antibodies for CAMK2G
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for CAMK2G
- Addgene plasmids for CAMK2G
- antibodies-online Antibodies for CAMK2G: See all 139
- antibodies-online Kits for CAMK2G: See all 4
- antibodies-online Proteins for CAMK2G: See all 10
- Search antibodies-online for peptides
- GeneTex CAMK2G antibody for CAMK2G
- Search GeneTex for Proteins for CAMK2G
- Search ViGene Biosciences for CAMK2G
- Santa Cruz Biotechnology (SCBT) Antibodies for CAMK2G
- Search Santa Cruz Biotechnology (SCBT) for CAMK2G siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CAMK2G
- Horizon Cell Lines for CAMK2G
- Cyagen custom Knockout/knockin (KOKI) mouse models for CAMK2G
- VectorBuilder custom plasmid, inducible vectors for CAMK2G
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CAMK2G
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CAMK2G Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
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- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
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- (122) diseasecard
- (123) NIH Rare Diseases
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- (128) Genetics Home Reference
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- (130) MedlinePlus
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- (141) ENCODE
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- (143) Horizon
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- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer