CAMK2G Gene
protein-coding GIFtS: 66
GCID: GC10M075572
|
|
calcium/calmodulin-dependent protein kinase II gamma(Previous name: calcium/calmodulin-dependent protein kinase (CaM kinase)...)
(Previous symbol: CAMKG)
| |
Aliases
for CAMK2G gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Calcium/Calmodulin-Dependent Protein Kinase II Gamma1 2 | | CAMK-II2 3 | | CAMKG1 2 3 5 | | EC 2.7.11.173 8 | | Calcium/Calmodulin-Dependent Protein Kinase (CaM Kinase) II Gamma1 2 | | Calcium/Calmodulin-Dependent Protein Kinase Type II Subunit Gamma2 | | CaMK-II Subunit Gamma2 3 | | CaM Kinase II Subunit Gamma3 | | CAMK2 3 | | EC 2.7.118 |
Export aliases for CAMK2G gene to outside databasesPrevious GC identifers: GC10M074352 GC10M074675 GC10M075464 GC10M074916 GC10M075242 GC10M069567 |
Summaries
for CAMK2G gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CAMK2G:
The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinasefamily, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for severalaspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains:alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcriptsencoding different isoforms have been described but the full-length nature of all the variants has not beendetermined.(provided by RefSeq, Mar 2011)
UniProtKB/Swiss-Prot: KCC2G_HUMAN, Q13555Function: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding andautophosphorylation, and is involved in sarcoplsamic reticulum Ca(2+) transport in skeletal muscle and may function indendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation ofsarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) releasefrom the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate inthe promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-termpotentiation (LTP) and hippocampus-dependent learning
 summary
for CAMK2G: Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second
messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through
autoinhibition. Increases in Ca2+ levels allows calmodulin to relieve this autoinhibition and activate the
kinase activity. There are two main classes of CaMKs; mulitfunctional CaMKs (CaMKK, CaMKI, CaMKII and
CaMKIV) which have multiple downstream targets and substrate-specific CaMKs (CaMKIII) which have only one
known downstream target. All CaMKs, with the exception of CaMKII, exist as monomers and most are expressed
ubiquitously. Some subtypes display specific distributions, for example, CaMKIVbeta is expressed exclusively
in cerebellar granule cells. CaMKs have numerous cellular functions and they influence processes as diverse
as gene transcription, cell survival, apoptosis, cytoskeletal re-organization and learning and memory.
Gene Wiki entry for CAMK2G
|
Genomic Views
for CAMK2G gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CAMK2G gene promoter:
STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for CAMK2G
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAMK2G |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q22 Ensembl cytogenetic band: 10q22.2 HGNC cytogenetic band: 10q22CAMK2G Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M075572: view genomic region
(about GC identifiers)
Start:
|
75,572,259 bp from pter |
End:
|
75,634,343 bp from pter |
Size:
|
62,085 bases |
Orientation:
|
minus strand |
|
Proteins
for CAMK2G gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KCC2G_HUMAN, Q13555 (See
protein sequence)Recommended Name: Calcium/calmodulin-dependent protein kinase type II subunit gamma Size: 558 amino acids; 62609 Da
Subunit: CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D).The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexamericrings stacked one on top of the other
Subcellular location: Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (Probable)
Sequence caution: Sequence=AAB61379.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
2 PDB 3D structures from  and Proteopedia  for CAMK2G:2UX0 (3D)
2V7O (3D)
Secondary accessions: O00561 O15378 Q13279 Q13282 Q13556 Q5SQZ3 Q5SQZ4 Q5SWX4 Q7KYX5 Q8N4I3 Q8NIA4Alternative splicing: 10 isoforms: Q13555-1 Q13555-2 Q13555-3 Q13555-4 Q13555-5 Q13555-6 Q13555-7 Q13555-8 Q13555-9 Q13555-10 (Contains a phosphoserine at position 325)Explore the universe of human proteins at neXtProt for CAMK2G: NX_Q13555
Post-translational modifications:
Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinaseinto an activated state1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13555
4/41 DME Specific Peptides for CAMK2G (Q13555) (see all 41)
CAMK2G Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (6 alternative transcripts):
NP_001191421.1 NP_001213.2 NP_751909.1 NP_751910.1 NP_751911.1 NP_751913.1
ENSEMBL proteins: ENSP00000277853 ENSP00000315599 ENSP00000393784 ENSP00000307082 ENSP00000361851 ENSP00000405561 ENSP00000410298 ENSP00000319060 ENSP00000378243 ENSP00000399680 Reactome Protein details: Q13555
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
CAMK2G for ontologies About GeneDecksing
CAMK2G Antibody Products:
Assay Products for CAMK2G: |
Protein
Domains /
Families
for CAMK2G gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CAMK2G for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q13555ProtoNet protein and cluster: Q13555 1 Blocks protein family: IPB013543 Calcium/calmodulin dependent protein kinase II
UniProtKB/Swiss-Prot: KCC2G_HUMAN, Q13555Domain: The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible foroligomerizationSimilarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamilySimilarity: Contains 1 protein kinase domain |
Function
for CAMK2G gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KCC2G_HUMAN, Q13555Function: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding andautophosphorylation, and is involved in sarcoplsamic reticulum Ca(2+) transport in skeletal muscle and may function indendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation ofsarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) releasefrom the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate inthe promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-termpotentiation (LTP) and hippocampus-dependent learningCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relievesintrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively activeform and confers to the kinase a Ca(2+)-independent activityInduction: Activity is induced in skeletal muscle during exercise Genatlas biochemistry entry for CAMK2G:protein kinase,calcium/calmodulin dependent,gammasubunit with several isoforms
Enzyme Numbers (IUBMB): EC 2.7.11.171 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAMK2G (see all 9)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAMK2G (see all 10)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 6): CAMK2G (NM_172169) | |  | Sino Biological Human cDNA Clone for CAMK2G | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CAMK2G | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMK2G |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMK2G |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004672 | protein kinase activity |
-- | -- | | GO:0004674 | protein serine/threonine kinase activity |
-- | -- | | GO:0004683 | calmodulin-dependent protein kinase activity |
IEA | -- | | GO:0004723 | calcium-dependent protein serine/threonine phosphatase activity |
NAS | 9060999 | | GO:0005515 | protein binding |
IPI | -- |
CAMK2G for ontologies About GeneDecksing
6 GenomeRNAi human phenotypes for CAMK2G:
Animal Models:
Mouse knock-out Camk2gtm1.1Irt for CAMK2G
5 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Camk2g):
CAMK2G for phenotypes About GeneDecksing
|
Pathways & Interactions
for CAMK2G gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/52 super-pathways (see all 52) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Development Angiotensin activation of ERK | | | 2 | Development_Endothelin-1/EDNRA transactivation of EGFR | | | 3 | Translation_Translation regulation by Alpha-1 adrenergic receptors | | | 4 | Immune response_IFN gamma signaling pathway | | | 5 | CREB phosphorylation through the activation of CaMKII | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/18 EMD Millipore Pathways for CAMK2G (see all 18)
1  R&D Systems Pathway for CAMK2G
5/18 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CAMK2G (see all 18)
2 
Cell Signaling Technology (CST) Pathways for CAMK2G
5/18  GeneGo (Thomson Reuters) Pathways for CAMK2G (see all 18)
5/8  BioSystems Pathways for CAMK2G (see all 8)
5/15 
Reactome Pathways for CAMK2G (see all 15)
1  PharmGKB Pathway for CAMK2G
5/13 
Kegg Pathways (Kegg details for CAMK2G) (see all 13):
CAMK2G for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CAMK2G
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/69 Interacting proteins for CAMK2G (Q135551, 3 ENSP000003190604) via UniProtKB, MINT, STRING, and/or I2D (see all 69)About this table
Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table
CAMK2G for ontologies About GeneDecksing
|
Drugs & Compounds
for CAMK2G gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CAMK2G for compounds About GeneDecksing
Compounds for CAMK2G available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| KN-62 | Non-competitive P2X7 antagonist | [127191-97-3] | | KN-93 | CaM kinase II inhibitor. Also K+ channel blocker (KV) | [139298-40-1] | | Autocamtide-2-related inhibitory peptide | Selective CaM kinase II inhibitor | [167114-91-2] | | Arcyriaflavin A | Potent cdk4/cyclin D1 and CaM Kinase II inhibitor. Antiviral agent (anti-HCMV) | [118458-54-1] |
1 DrugBank Compound for CAMK2G About this table
10/112 Novoseek chemical compound relationships for CAMK2G gene (see all 112) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| kn 93 |
93.4 |
77 |
16730662 (4), 10896725 (3), 9517449 (2), 20353560 (2) (see all 46) |
| kn62 |
86.6 |
28 |
7588388 (2), 9517449 (2), 8989364 (1), 10919847 (1) (see all 21) |
| calcium |
82.3 |
901 |
16040245 (6), 16608699 (5), 15687337 (5), 14572807 (5) (see all 99) |
| syntide-2 |
82.1 |
10 |
8981450 (1), 7836445 (1), 16172120 (1), 12580100 (1) (see all 9) |
| calmidazolium |
78.6 |
13 |
19545622 (2), 9003023 (1), 12193581 (1), 10196527 (1) (see all 11) |
| nmda |
73 |
157 |
9694809 (5), 17602661 (4), 9751209 (4), 8120627 (3) (see all 79) |
| glutamate |
63.7 |
87 |
9032658 (2), 7877986 (2), 15769546 (2), 16337157 (2) (see all 61) |
| ionomycin |
61.7 |
29 |
11129962 (4), 15383398 (3), 7850948 (2), 8770046 (2) (see all 16) |
| ryanodine |
58.7 |
16 |
19883653 (2), 20194790 (2), 10811820 (1), 19342611 (1) (see all 9) |
| okadaic acid |
58.2 |
14 |
19254957 (1), 11129962 (1), 17553505 (1), 10899954 (1) (see all 12) |
Search CenterWatch for drugs/clinical trials and news about CAMK2G / KCC2G
|
Transcripts
for CAMK2G gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CAMK2G gene (7 alternative transcripts): NM_001204492.1 NM_001222.3 NM_172169.2 NM_172170.4 NM_172171.2 NM_172173.2 NM_172172.1 Unigene Cluster for CAMK2G: Calcium/calmodulin-dependent protein kinase II gamma Hs.523045 [show with all ESTs]Unigene Representative Sequence: AB20947416 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000351293 ENST00000322635 ENST00000433289 ENST00000305762 ENST00000372765
ENST00000441192(uc009xrp.1 uc001jvw.1) ENST00000472912(uc010qkv.2)
ENST00000474131 ENST00000487167 ENST00000477205 ENST00000492020 ENST00000477652
ENST00000423381(uc001jvs.2 uc001jvo.2 uc001jvt.2) ENST00000322680(uc001jvm.2 uc001jvp.2 uc001jvq.2 uc001jvv.2)
ENST00000394762(uc001jvr.2 uc001jvx.1) ENST00000444854
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAMK2G (see all 9)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAMK2G (see all 10)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 6): CAMK2G (NM_172169) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CAMK2G | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMK2G |
Additional cDNA sequence: AB209474.1 AK026309.1 AK131199.1 AK225771.1 AK291704.1 AK301180.1 BC012795.2 BC021269.2 BC034044.1 BC037928.1 L07043.1 L07044.1 U32472.1 U32473.1 U32509.1 U50359.1 U50360.1 U66063.1 U66064.1 24/29 DOTS entries (see all 29): DT.91752791 DT.444370 DT.99984302 DT.95275517 DT.100885670 DT.100674303 DT.434248 DT.91752790 DT.100827661 DT.116882 DT.121239498 DT.121239459 DT.91752787 DT.95180782 DT.100743530 DT.423427 DT.95275534 DT.100803750 DT.121239447 DT.121239458 DT.121239494 DT.75134549 DT.75174775 DT.95275521 24/388 AceView cDNA sequences (see all 388): CR618627 AI052299 U32509 U50360 F11850 AW470122 NM_001222 BQ719803 BX094357 BM824896 U32472 AI206433 BQ182120 AA352230 BF222507 NM_172171 AI198105 AI376651 CA430684 BQ272328 AI241587 BE671529 AW964040 AA305107
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for CAMK2G (see all 11) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b | ^ |
|---|
|
| SP1: | | | | | | | - | | | | | | - | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | |
| SP3: | | | | | | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | - | |
| ExUns: | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | ^ | 24a | · | 24b | · | 24c | ^ | 25a | · | 25b | ^ | 26a | · | 26b |
|---|
|
| SP1: | - | | | | | | | | | | - | | | | | | - | | - | | | | | | | | | | |
| SP2: | - | | | | | | - | | - | | - | | | | | | - | | - | | | | | | | | | | |
| SP3: | - | | | | | | - | | - | | - | | | | | | - | | - | | | | | | | | | | |
| SP4: | - | | | | | | | | - | | - | | | | | | - | | - | | | | | | | | | | |
| SP5: | - | | | | | | - | | - | | - | | | | | | - | | - | | | | | | | | | |
ECgene alternative splicing isoforms for CAMK2G
|
Expression
for CAMK2G gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CAMK2G expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACAACATAGA
About this image
See CAMK2G Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CAMK2G
SOURCE GeneReport for Unigene cluster: Hs.523045
UniProtKB/Swiss-Prot: KCC2G_HUMAN, Q13555Tissue specificity: Expressed in skeletal muscle
SABiosciences Expression via Pathway-Focused PCR Arrays including CAMK2G:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CAMK2G
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CAMK2G | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAMK2G | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAMK2G | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMK2G |
Orthologs
for CAMK2G gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CAMK2G gene from 6/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CAMK2G1 |
calcium/calmodulin-dependent protein kinase II gamma |
83.11(n)
94.37(a) |
|
423737 XM_421612.3 XP_421612.3 |
lizard
(Anolis carolinensis) |
Reptilia |
CAMK2G6 |
-- |
91(a) |
1 ↔ 1 |
GL343196.1(1538333-1618048) |
African clawed frog
(Xenopus laevis) |
Amphibia |
camk2g-prov2 |
calcium/calmodulin-dependent protein kinase (CaM kinase) more |
79.7(n) |
|
AF233632.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
camk2g11 |
calcium/calmodulin-dependent protein kinase (CaM kinase) more |
76.56(n)
87.8(a) |
|
791855 NM_001030125.1 NP_001025296.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CaMKII6 |
Calcium/calmodulin-dependent protein kinase II |
72(a) |
1 → many |
4(1055914-1074329) |
worm
(Caenorhabditis elegans) |
Secernentea |
unc-436 |
UNCoordinated family member (unc-43) |
49(a) |
1 → many |
IV(10324295-10350196) |
ENSEMBL Gene Tree for CAMK2G (if available)
TreeFam Gene Tree for CAMK2G (if available) |
Paralogs
for CAMK2G gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CAMK2G gene
- PNCK2 CAMK1G2 PSKH22 DCX2 DCLK22 CAMK2A2 CAMK1D2 DCLK12
- PSKH12 CAMK42 CAMK2D2 DCLK32 CAMKV2 CAMK2B2 CAMK12
18/50 SIMAP similar genes for CAMK2G using alignment to 6 protein entries: KCC2G_HUMAN (see all proteins)
(see all similar genes):CAMK2B CAMK2D CAMK2A CDK4 CASK PNCK
DCLK3 MAPKAPK5 STK11 PRKAA1 CAMK1D PHKG2
STK17A RPS6KA3 PRKY PSKH1 DAPK3 MGC45428
CAMK2G for paralogs About GeneDecksing
|
Genomic Variants
for CAMK2G gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CAMK2G (75572259 - 75634343 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CAMK2G
2 CNVs: 48629 71044 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CAMK2G |
|
Disorders
/ Diseases
for CAMK2G gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CAMK2G for disorders About GeneDecksing
OMIM gene information: 602123
OMIM disorders: --
20/57  diseases for CAMK2G (see all 57): About MalaCardsattention deficit hyperactivity disorder transient cerebral ischemia temporal lobe epilepsy atrial fibrillation
status epilepticus brain injury usher syndrome timothy syndrome
drug dependence hairy cell leukemia brain ischemia muscle hypertrophy
tauopathy cystic fibrosis myeloid leukemia ischemia
papillary thyroid carcinoma tetanus burkitt's lymphoma brain disease
10/47 Novoseek disease relationships for CAMK2G gene (see all 47) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cardiac hypertrophy |
44.1 |
15 |
15276473 (3), 18056528 (3), 16511595 (1), 16610345 (1) (see all 8) |
| heart failure |
28.3 |
30 |
15276473 (2), 19883653 (2), 16138211 (2), 17704163 (2) (see all 16) |
| hypertrophy |
27.8 |
13 |
20023119 (3), 19207476 (3), 18803570 (1), 19997488 (1) (see all 8) |
| alzheimers disease |
27.5 |
6 |
7820630 (2), 14665412 (1), 17241267 (1), 19536656 (1) (see all 5) |
| tauopathies |
25.3 |
2 |
11810404 (2) |
| tetanus |
24.1 |
8 |
10798500 (2), 10479685 (1), 19450629 (1), 9204925 (1) (see all 5) |
| neurofibrillary tangles |
22.9 |
2 |
2120043 (1), 7820630 (1) |
| transient cerebral ischemia |
19 |
1 |
1331917 (1) |
| arrhythmia |
18.2 |
30 |
18803570 (3), 17254559 (3), 19333131 (2), 19997488 (2) (see all 12) |
| myeloid leukemia |
10.9 |
5 |
17431504 (2), 11376870 (1), 17644368 (1), 19388154 (1) |
Human Genome Epidemiology (HuGE) Navigator: CAMK2G (7 documents)
Export disorders for CAMK2G gene to outside databases
|
Publications
for CAMK2G gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CAMK2G gene, integrated from 9 sources (see all 851):
(articles sorted by number of sources associating them with CAMK2G) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of novel human tumor cell-specific CaMK-II variants. (PubMed id 9060999)1, 2, 9 Tombes R.M. and Krystal G.W. (1997)
- Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II. (PubMed id 14722083)1, 2 Gaertner T.R....Waxham M.N. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- The role of calcium and calcium/calmodulin-dependent kinases in skeletal muscle plasticity and mitochondrial biogenesis. (PubMed id 15294044)1, 2 Chin E.R. (2004)
- Human calcium/calmodulin-dependent protein kinase II gamma: cloning, genomic structure and detection of variants in subjects with type ii diabetes. (PubMed id 12032636)1, 2 Gloyn A.L.... Ashcroft S.J. (2002)
- Human islets of Langerhans express multiple isoforms of calcium/calmodulin-dependent protein kinase II. (PubMed id 9240463)1, 2 Breen M.A. and Ashcroft S.J. (1997)
- Human biliary epithelial cell line Mz-ChA-1 expresses new isoforms of calmodulin-dependent protein kinase II. (PubMed id 7557101)1, 2 Kwiatkowski A.P. and McGill J.M. (1995)
- Localization of the CAMKG gene encoding gamma isoforms of multifunctional calcium/calmodulin-dependent protein kinase (CaM kinase) to human chromosome 10 band q22 and mouse chromosome 14. (PubMed id 8287681)1, 3 Li X....Francke U. (1994)
- Cloning and analysis of two new isoforms of multifunctional Ca/Calmodulin-dependent protein kinase. (PubMed id 8449910)1, 2 Nghiem P.... Schulman H. (1993)
- Regulation of CaMKII by phospho-Thr253 or phospho-Thr 286 sensitive targeting alters cellular function. (PubMed id 20060891)1, 9 Skelding K.A....Rostas J.A. (2010)
|
External Searches for CAMK2G gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CAMK2G gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CAMK2G gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CAMK2G gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CAMK2G | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CAMK2G gene:
Search GeneIP for patents involving CAMK2G
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CAMK2G gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for CAMK2G | | OriGene shRNA RFP for CAMK2G | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAMK2G | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CAMK2G | | | OriGene Protein Over-expression Lysate for CAMK2G | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CAMK2G | | OriGene 3'-UTR Clone for CAMK2G | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAMK2G | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAMK2G | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CAMK2G | | OriGene Custom Protein Services for CAMK2G | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CAMK2G | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CAMK2G | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAMK2G | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAMK2G | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAMK2G | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAMK2G |
| |
 |  |  |  | |
| | Antibodies & Assays for CAMK2G (CaMK2-gamma) |
| | | |  |  |  |  | | | | |
 |
 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMK2G |
|  |  |  | | | | ThermoFisher Antibodies for CAMK2G |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMK2G |
|
|
|
|
