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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CAMK2D Gene

protein-coding   GIFtS: 68
GCID: GC04M114372

Calcium/Calmodulin-Dependent Protein Kinase II Delta

(Previous name: calcium/calmodulin-dependent protein kinase (CaM kinase)...)
(Previous symbol: CAMKD)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Calcium/Calmodulin-Dependent Protein Kinase II Delta1 2     Calcium/Calmodulin-Dependent Protein Kinase Type II Delta Chain2
CAMKD1 2 3     Calcium/Calmodulin-Dependent Protein Kinase Type II Subunit Delta2
Calcium/Calmodulin-Dependent Protein Kinase (CaM Kinase) II Delta1 2     CaM Kinase II Delta Subunit2
CaM Kinase II Subunit Delta2 3     CaM-Kinase II Delta Chain2
CaMK-II Subunit Delta2 3     CaMK-II Delta Subunit2
EC 2.7.11.173 8     EC 2.7.118

External Ids:    HGNC: 14621   Entrez Gene: 8172   Ensembl: ENSG000001453497   OMIM: 6077085   UniProtKB: Q135573   

Export aliases for CAMK2D gene to outside databases

Previous GC identifers: GC04M114789 GC04M114655 GC04M114832 GC04M114731 GC04M110100


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CAMK2D Gene:
The product of this gene belongs to the serine/threonine protein kinase family and to the
Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of
plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha,
beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple
transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression
patterns.(provided by RefSeq, Nov 2008)

GeneCards Summary for CAMK2D Gene: 
CAMK2D (calcium/calmodulin-dependent protein kinase II delta) is a protein-coding gene. Diseases associated with CAMK2D include reflex epilepsy, and insulinoma, and among its related super-pathways are Wnt signaling pathway and Development Endothelin-1/EDNRA transactivation of EGFR. GO annotations related to this gene include calmodulin binding and calmodulin-dependent protein kinase activity. An important paralog of this gene is PNCK.

UniProtKB/Swiss-Prot: KCC2D_HUMAN, Q13557
Function: Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and
excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins
involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake
and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate
heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart
failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct
phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4,
promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the
hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In
pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate
key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type
Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac
sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in
heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to
the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation
(FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal
muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and
triadin, a ryanodine receptor-coupling factor

summary for CAMK2D Gene:
Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second
messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through
autoinhibition. Increases in Ca2+ levels allows calmodulin to relieve this autoinhibition and activate the
kinase activity. There are two main classes of CaMKs; mulitfunctional CaMKs (CaMKK, CaMKI, CaMKII and
CaMKIV) which have multiple downstream targets and substrate-specific CaMKs (CaMKIII) which have only one
known downstream target. All CaMKs, with the exception of CaMKII, exist as monomers and most are expressed
ubiquitously. Some subtypes display specific distributions, for example, CaMKIVbeta is expressed exclusively
in cerebellar granule cells. CaMKs have numerous cellular functions and they influence processes as diverse
as gene transcription, cell survival, apoptosis, cytoskeletal re-organization and learning and memory.

Gene Wiki entry for CAMK2D Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CAMK2D gene promoter:
         ER-alpha   TBP   CUTL1   FOXL1   Max   FAC1   HOXA5   FOXJ2 (long isoform)   FOXJ2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCAMK2D promoter sequence
   Search SABiosciences Chromatin IP Primers for CAMK2D

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAMK2D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q26   Ensembl cytogenetic band:  4q26   HGNC cytogenetic band: 4q26

CAMK2D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAMK2D gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M114372:  view genomic region     (about GC identifiers)

Start:
114,372,188 bp from pter      End:
114,683,083 bp from pter
Size:
310,896 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KCC2D_HUMAN, Q13557 (See protein sequence)
Recommended Name: Calcium/calmodulin-dependent protein kinase type II subunit delta  
Size: 499 amino acids; 56369 Da
Subunit: CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta
(CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with
two hexameric rings stacked one on top of the other. Interacts with RRAD and CACNB2 (By similarity)
Subcellular location: Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side (Probable).
Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (Probable)
Miscellaneous: Expression of CAMK2D is significantly increased in patients suffering from dilated cardiomyopathy
in PubMed:10189359
Sequence caution: Sequence=BAD92525.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
4 PDB 3D structures from and Proteopedia for CAMK2D:
2VN9 (3D)        2W2C (3D)        2WEL (3D)        3GP2 (3D)    
Secondary accessions: A8MVS8 Q52PK4 Q59G21 Q8N553 Q9UGH6 Q9UQE9
Alternative splicing: 10 isoforms:  Q13557-1   Q13557-3   Q13557-4   Q13557-8   Q13557-9   Q13557-5   Q13557-6   Q13557-10   
Q13557-11   Q13557-12   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CAMK2D: NX_Q13557

Explore proteomics data for CAMK2D at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the
    kinase into an activated state
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13557

  • 4/49 DME Specific Peptides for CAMK2D (Q13557) (see all 49)
     TEQLIEA  TTIEDED  YTKICDP  PEAKDLI 

    CAMK2D Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CAMK2D Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001212.2  NP_742112.1  NP_742113.1  NP_742125.1  NP_742126.1  NP_742127.1  

    ENSEMBL proteins: 
     ENSP00000378032   ENSP00000424247   ENSP00000425824   ENSP00000339740   ENSP00000423482  
     ENSP00000423677   ENSP00000378030   ENSP00000424245   ENSP00000369098   ENSP00000422566  
     ENSP00000423753   ENSP00000415248   ENSP00000415707   ENSP00000406131   ENSP00000378034  
     ENSP00000296402  
    Reactome Protein details: Q13557
    Human Recombinant Protein Products for CAMK2D: 
    EMD Millipore Purified and/or Recombinant CAMK2D Protein
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    OriGene Protein Over-expression Lysate for CAMK2D
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    GenScript Custom Purified and Recombinant Proteins Services for CAMK2D
    Novus Biologicals CAMK2D Proteins
    Novus Biologicals CAMK2D Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/14 cellular component terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS12676814
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ISS12676814
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--

    CAMK2D for ontologies           About GeneDecksing



    CAMK2D Antibody Products: 
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    Novus Biologicals CAMK2D Antibodies
    Abcam antibodies for CAMK2D
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    ThermoFisher Antibody for CAMK2D
    LSBio Antibodies in human, mouse, rat for CAMK2D 

    Assay Products for CAMK2D: 
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: calcium/calmodulin-dependent protein kinase II delta subunit 
    CAMK2 family
    Selected non-AGC protein kinase activities

    5/7 InterPro protein domains (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q13557

    ProtoNet protein and cluster: Q13557

    1 Blocks protein domain: IPB013543 Calcium/calmodulin dependent protein kinase II

    UniProtKB/Swiss-Prot: KCC2D_HUMAN, Q13557
    Domain: The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for
    oligomerization
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily
    Similarity: Contains 1 protein kinase domain


    CAMK2D for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCC2D_HUMAN, Q13557
    Function: Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and
    excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins
    involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake
    and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate
    heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart
    failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct
    phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4,
    promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the
    hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In
    pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate
    key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type
    Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac
    sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in
    heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to
    the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation
    (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal
    muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and
    triadin, a ryanodine receptor-coupling factor
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that
    relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a
    constitutively active form and confers to the kinase a Ca(2+)-independent activity
    Induction: Activity is induced in skeletal muscle during exercise

         Enzyme Numbers (IUBMB): EC 2.7.11.171 2 EC 2.7.112

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004683calmodulin-dependent protein kinase activity IDA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding ----
         
    CAMK2D for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for CAMK2D:
     Decreased focal adhesion (FA)   Increased HPV18 LCR reporter a  Increased apoptosis  Increased cell death HMECs cel 
     Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Camk2d):
     cardiovascular system  homeostasis/metabolism  no phenotypic analysis 

    CAMK2D for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CAMK2D: Camk2dtm1.1Jhb Camk2dtm1.2Eno

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CAMK2D 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CAMK2D

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAMK2D 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAMK2D 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAMK2D
    8/81 QIAGEN miScript miRNA Assays for microRNAs that regulate CAMK2D (see all 81):
    hsa-miR-607 hsa-miR-361-5p hsa-miR-3074-3p hsa-miR-30d hsa-miR-890 hsa-miR-30a hsa-miR-3150b-3p hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidCAMK2D 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CAMK2D
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAMK2D

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CAMK2D
    Sirion Biotech Customized adenovirus for overexpression of CAMK2D

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CAMK2D (see all 35)
    OriGene ORF clones in mouse, rat for CAMK2D
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): CAMK2D (NM_172128)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAMK2D
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMK2D
    Sirion Biotech Customized lentivirus for stable overexpression of CAMK2D 
                         Customized lentivirus expression plasmids for stable overexpression of CAMK2D 

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMK2D


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CAMK2D About   (see all 52)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathway0.40
    2Development Endothelin-1/EDNRA signaling
    Development Endothelin-1/EDNRA signaling0.41
    Cytoskeleton remodeling FAK signaling0.41
    Development Endothelin-1/EDNRA transactivation of EGFR0.41
    GnRH signaling pathway0.38
    3ErbB signaling pathway
    ErbB signaling pathway0.52
    EGFR Inhibitor Pathway, Pharmacodynamics0.49
    4Immune response IFN gamma signaling pathway
    Immune response IFN gamma signaling pathway0.43
    IFN-gamma pathway0.43
    5fMLP Pathway
    Alpha-Adrenergic Signaling0.38
    Signal transduction Calcium signaling0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/18 EMD Millipore Pathways for CAMK2D (see all 18)
        Translation Translation regulation by Alpha-1 adrenergic receptors
    Development Activation of ERK by Alpha-1 adrenergic receptors
    Cytoskeleton remodeling FAK signaling
    Signal transduction IP3 signaling
    Cell adhesion Integrin inside-out signaling

    1 R&D Systems Pathway for CAMK2D
        Wnt Signaling Pathway

    5/18 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CAMK2D (see all 18)
        Molecular Mechanisms of Cancer
    PI3K Signaling in B-Lymphocyte
    Melatonin Signaling
    IP3 Pathway
    CREB Pathway

    2 Cell Signaling Technology (CST) Pathways for CAMK2D
        Ca, cAMP and Lipid Signaling
    Neuroscience

    5/18 GeneGo (Thomson Reuters) Pathways for CAMK2D (see all 18)
        Development Endothelin-1/EDNRA transactivation of EGFR
    Signal transduction cAMP signaling
    Development Endothelin-1/EDNRA signaling
    Development Angiotensin signaling via PYK2
    Development Activation of ERK by Alpha-1 adrenergic receptors

    5/8 BioSystems Pathways for CAMK2D (see all 8)
        MicroRNAs in cardiomyocyte hypertrophy
    Myometrial Relaxation and Contraction Pathways
    Calcium Regulation in the Cardiac Cell
    SRF and miRs in Smooth Muscle Differentiation and Proliferation
    TGF-beta Receptor Signaling Pathway

    5/15        Reactome Pathways for CAMK2D (see all 15)
        Ras activation uopn Ca2+ infux through NMDA receptor
    Interferon gamma signaling
    Unblocking of NMDA receptor, glutamate binding and activation
    CREB phosphorylation through the activation of CaMKII
    Cytokine Signaling in Immune system

    1 PharmGKB Pathway for CAMK2D
        EGFR Inhibitor Pathway, Pharmacodynamics

    5/19         Kegg Pathways  (Kegg details for CAMK2D) (see all 19):
        ErbB signaling pathway
    Calcium signaling pathway
    HIF-1 signaling pathway
    Oocyte meiosis
    Wnt signaling pathway


    CAMK2D for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CAMK2D

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/96 Interacting proteins for CAMK2D (Q135572, 3 ENSP000003397404) via UniProtKB, MINT, STRING, and/or I2D (see all 96)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IKBKGQ9Y6K92, 3MINT-48204 I2D: score=2 
    ENSG00000226225P622693, ENSP000004031754I2D: score=2 STRING: ENSP00000403175
    RPS18P622693, ENSP000003932414I2D: score=2 STRING: ENSP00000393241
    ENSG00000096150P622693I2D: score=2 
    ENSG00000223367P622693I2D: score=2 
    About this table

    Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IEA--
    GO:0001558regulation of cell growth NAS9060999
    GO:0002026regulation of the force of heart contraction TAS--
    GO:0002028regulation of sodium ion transport IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS--

    CAMK2D for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CAMK2D for compounds           About GeneDecksing

    EMD Millipore small molecules for CAMK2D:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CAMK2D available from Tocris Bioscience    About this table
    CompoundAction CAS #
    NH 125CaM kinase III (eEF-2 kinase) inhibitor[278603-08-0]
    STO-609 acetateSelective CaM kinase kinase inhibitor[52029-86-4]
    A 484954CaM kinase III (eEF-2 kinase) inhibitor[142557-61-7]
    KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
    Arcyriaflavin APotent cdk4/cyclin D1 and CaM Kinase II inhibitor. Antiviral agent (anti-HCMV)[118458-54-1]

    3 HMDB Compounds for CAMK2D    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--

    2 DrugBank Compounds for CAMK2D    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE-- --target--10592235
    [4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE-- --target--10592235

    1 Novoseek inferred chemical compound relationship for CAMK2D gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 27.7 2 11451385 (1), 18486612 (1)

    Search CenterWatch for drugs/clinical trials and news about CAMK2D / KCC2D

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CAMK2D gene (6 alternative transcripts): 
    NM_001221.3  NM_172114.1  NM_172115.2  NM_172127.2  NM_172128.2  NM_172129.1  

    Unigene Cluster for CAMK2D:

    Calcium/calmodulin-dependent protein kinase II delta
    Hs.144114  [show with all ESTs]
    Unigene Representative Sequence: NM_001221
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394524 ENST00000513132 ENST00000511664 ENST00000342666 ENST00000515496
    ENST00000514328 ENST00000394522 ENST00000505990 ENST00000379773 ENST00000508738
    ENST00000509594 ENST00000509907 ENST00000505132 ENST00000454265 ENST00000429180(uc003ibo.4)
    ENST00000418639 ENST00000394526(uc003ibi.3) ENST00000296402(uc003ibj.3 uc003ibk.3 uc003ibm.2 uc003ibn.2 uc003ibl.2)

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    Additional mRNA sequence: 

    AB209288.1 AF071569.1 AJ252239.1 AK025368.1 AK055642.1 AK294517.1 AY987011.1 BC022558.1 
    BC032784.1 BX538071.1 BX647363.1 EF139846.1 U50361.1 U73738.1 

    19 DOTS entries:

    DT.454654  DT.318204  DT.100026499  DT.312104  DT.100787061  DT.121264415  DT.100787058  DT.100787059 
    DT.86846189  DT.95350739  DT.100753377  DT.97812745  DT.424214  DT.95373924  DT.75190472  DT.100712732 
    DT.91862551  DT.97795028  DT.97816747 

    24/385 AceView cDNA sequences (see all 385):

    AW630893 BM354204 AI432148 W88760 CB106867 AL120285 CA432186 AI432714 
    AA448956 AA811315 AI057019 AI124777 AK055642 AA777583 AV655906 AA490727 
    BU785514 AA233206 AL701498 H42887 AA860658 CA412412 AA777512 CF136256 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CAMK2D (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ·
    SP1:                                      -     -                             -                                                                                 
    SP2:                                      -     -                             -                                               -                             -   
    SP3:                                      -     -                             -                                               -                                 
    SP4:                                      -     -                       -                                                                                       
    SP5:                                                                                                                          -                                 

    ExUns: 20c · 20d ^ 21
    SP1:                  
    SP2:  -     -         
    SP3:                  
    SP4:                  
    SP5:  -     -         


    ECgene alternative splicing isoforms for CAMK2D

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CAMK2D expression in normal human tissues (normalized intensities)      CAMK2D embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGACACTGTA
    CAMK2D Expression
    About this image


    CAMK2D expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Cerebral Cortex
             ganglion/cranial/facial VII   
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             sigmoid colon mucosa   
     
     Neural Crest (Gastrulation Derivatives)
             mesenchyme   
     
     Nose (Sensory Organs)
             sensory organ/nose/nasal cavity   

    See CAMK2D Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CAMK2D

    SOURCE GeneReport for Unigene cluster: Hs.144114

    UniProtKB/Swiss-Prot: KCC2D_HUMAN, Q13557
    Tissue specificity: Expressed in cardiac muscle and skeletal muscle. Isoform Delta 3, isoform Delta 2, isoform
    Delta 8 and isoform Delta 9 are expressed in cardiac muscle. Isoform Delta 11 is expressed in skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Arrays including CAMK2D: 
              Circadian Rhythms in human mouse rat
              Neurotoxicity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CAMK2D gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Camk2d1 , 5 calcium/calmodulin-dependent protein kinase II, delta1, 5 88.39(n)1
    96.93(a)1
      3 (55.97 cM)5
    1080581  NM_001025439.11  NP_001020610.11 
     1265963025 
    chicken
    (Gallus gallus)
    Aves CAMK2D1 calcium/calmodulin-dependent protein kinase II delta 87.77(n)
    98.95(a)
      422688  NM_001039300.1  NP_001034389.1 
    lizard
    (Anolis carolinensis)
    Reptilia CAMK2D6
    calcium/calmodulin-dependent protein kinase II del...
    90(a)
    1 ↔ 1
    5(142350858-142537927)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.6902 Xenopus laevis calcium/calmodulin-dependent protein more 83.93(n)    AF233629.1 
    zebrafish
    (Danio rerio)
    Actinopterygii camk2d21 calcium/calmodulin-dependent protein kinase (CaM kinase) more 78.03(n)
    91.74(a)
      436815  NM_001002542.1  NP_001002542.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CaMKII1 , 3 learning and/or memory protein
    serine/threonine more3
    Calcium/calmodulin-dependent protein kinase II1
    74(a)3
    70.23(n)1
    80.71(a)1
      438281  NM_001169362.11  NP_001162833.11 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-431 Protein UNC-43 64.76(n)
    72.03(a)
      177921  NM_001028129.2  NP_001023300.1 
    rice
    (Oryza sativa)
    Liliopsida Os11g01366001 hypothetical protein 45.89(n)
    37.68(a)
      4349714  NM_001072223.1  NP_001065691.1 


    ENSEMBL Gene Tree for CAMK2D (if available)
    TreeFam Gene Tree for CAMK2D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CAMK2D gene
    PNCK2  CAMK1G2  PSKH22  PHKG22  CAMK2A2  CAMK1D2  PSKH12  CAMK42  
    PHKG12  CAMKV2  CAMK2G2  CAMK2B2  CAMK12  
    18/91 SIMAP similar genes for CAMK2D using alignment to 7 protein entries:     KCC2D_HUMAN (see all proteins) (see all similar genes):
    CAMK2A    CAMK2B    CAMK2G    CASK    PNCK    DCLK3
    KIAA0999    DAPK3    CAMK1D    BRAF    DCLK1    PRKAA1
    RPS6KA1    CAMK1    PHKG2    CDK4    BRSK2    DKFZp564L2416

    CAMK2D for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5736 SNPs in CAMK2D are shown (see all 5736)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs345693441,2
    C--110123995(+) TGGCC-/TT/TTT
            
    TTTTT
    6 -- int11NA 2
    rs1156461441,2
    F--114371724(+) TGCTGT/CAGTGA 3 -- ds50011Minor allele frequency- C:0.04WA 118
    rs1998568641,2
    --114371766(+) TTTCA-/AATT  
            
    AATTA
    3 -- ds50010--------
    rs1456113001,2
    C--114371768(+) TCAAA-/TTAAT 
            
    TAAGC
    3 -- ds50010--------
    rs23526561,2
    C--114371772(+) ATTAAA/TTAAGC 3 -- ds50010--------
    rs1505758441,2
    --114371803(+) TGACAC/TATCCA 3 -- ds50010--------
    rs1161314051,2
    F--114372113(+) TACGCT/GGATCT 3 -- ds50011Minor allele frequency- G:0.03WA 118
    rs170460691,2
    C,F--114372227(+) TCACTC/TGAAAG 3 -- ut313Minor allele frequency- T:0.01NA 140
    rs1493078921,2
    --114372410(+) GCTGAG/TACATT 3 -- ut310--------
    rs1831389851,2
    --114372436(+) CCTCAA/GCATTA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for CAMK2D (114372188 - 114622188 bp, first 250kb of CAMK2D)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for CAMK2D:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2677203CNV Deletion23128226
    esv270214CNV Insertion20981092
    nsv507189CNV Insertion20534489
    nsv4474CNV Insertion18451855
    nsv4475CNV Loss18451855
    nsv830038CNV Gain17160897
    nsv525087CNV Gain19592680
    esv260045OTHER Complex20981092

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607708    OMIM disorders: --

    13 diseases for CAMK2D:    About MalaCards
    reflex epilepsy    insulinoma    alcohol dependence    dilated cardiomyopathy
    down syndrome    alcoholism    myocardial infarction    ovarian cancer
    hypertension    tuberculosis    endotheliitis    breast cancer
    neuronitis


    CAMK2D for disorders           About GeneDecksing

    Genetic Association Database (GAD): CAMK2D
    Human Genome Epidemiology (HuGE) Navigator: CAMK2D (3 documents)

    Export disorders for CAMK2D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CAMK2D gene, integrated from 9 sources (see all 82):
    (articles sorted by number of sources associating them with CAMK2D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A systematic gene-based screen of chr4q22-q32 identif ies association of a novel susceptibility gene, DKK2, with the quantitative tra it of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (2010)
    2. Structure of the CaMKIIdelta/calmodulin complex revea ls the molecular mechanism of CaMKII kinase activation. (PubMed id 20668654)1, 2 Rellos P....Knapp S. (2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease. (PubMed id 19132087)1, 4 Burgner D....Hibberd M.L. (2009)
    5. Cardiac ryanodine receptor phosphorylation by CaM Kin ase II: keeping the balance right. (PubMed id 19482609)1, 2 Currie S. (2009)
    6. Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart. (PubMed id 17157285)1, 2 Maier L.S. and Bers D.M. (2007)
    7. Nuclear calcium/calmodulin-dependent protein kinase IIdelta preferentially transmits signals to histone deacetylase 4 in cardiac cells. (PubMed id 17179159)1, 2 Little G.H....Poizat C. (2007)
    8. Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II. (PubMed id 14722083)1, 2 Gaertner T.R....Waxham M.N. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 817 HGNC: 1462 AceView: CAMK2D Ensembl:ENSG00000145349 euGenes: HUgn817
    ECgene: CAMK2D Kegg: 817 H-InvDB: CAMK2D

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CAMK2D Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CAMK2D gene:
    Search GeneIP for patents involving CAMK2D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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     SwitchGear Promoter luciferase reporter plasmids for CAMK2D
     ThermoFisher Antibody for CAMK2D
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMK2D
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CAMK2D
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CAMK2D
    Customized:
     lentivirus for stable overexpression of CAMK2D
     lentivirus expression plasmids for stable overexpression of CAMK2D
     adenovirus for overexpression of CAMK2D
     LSBio Antibodies in human, mouse, rat for CAMK2D
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    transforming growth factor, beta 1
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