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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CAMK2D Gene

protein-coding   GIFtS: 66
GCID: GC04M114372

calcium/calmodulin-dependent protein kinase II delta

(Previous name: calcium/calmodulin-dependent protein kinase (CaM kinase)...)
(Previous symbol: CAMKD)
 Explore 18 diseases affiliated with
CAMK2D via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CAMK2D    

Aliases
for CAMK2D gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Calcium/Calmodulin-Dependent Protein Kinase II Delta1 2     Calcium/Calmodulin-Dependent Protein Kinase Type II Delta Chain2
CAMKD1 2 3     Calcium/Calmodulin-Dependent Protein Kinase Type II Subunit Delta2
Calcium/Calmodulin-Dependent Protein Kinase (CaM Kinase) II Delta1 2     CaM Kinase II Delta Subunit2
CaM Kinase II Subunit Delta2 3     CaM-Kinase II Delta Chain2
CaMK-II Subunit Delta2 3     CaMK-II Delta Subunit2
EC 2.7.11.173 8     EC 2.7.118

External Ids:    HGNC: 14621   Entrez Gene: 8172   Ensembl: ENSG000001453497   OMIM: 6077085   UniProtKB: Q135573   

Export aliases for CAMK2D gene to outside databases

Previous GC identifers: GC04M114789 GC04M114655 GC04M114832 GC04M114731 GC04M110100


Summaries
for CAMK2D gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CAMK2D:
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent
protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In
mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this
gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Distinct isoforms of this chain have different expression patterns.(provided by RefSeq, Nov 2008)

UniProtKB/Swiss-Prot: KCC2D_HUMAN, Q13557
Function: Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and
excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved
in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and
K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its
activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac
decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on
'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to
14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left
ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of
the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to
myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+)
channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3,
which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor
of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent
acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the
modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through
phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor

summary for CAMK2D:
Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second
messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through
autoinhibition. Increases in Ca2+ levels allows calmodulin to relieve this autoinhibition and activate the
kinase activity. There are two main classes of CaMKs; mulitfunctional CaMKs (CaMKK, CaMKI, CaMKII and
CaMKIV) which have multiple downstream targets and substrate-specific CaMKs (CaMKIII) which have only one
known downstream target. All CaMKs, with the exception of CaMKII, exist as monomers and most are expressed
ubiquitously. Some subtypes display specific distributions, for example, CaMKIVbeta is expressed exclusively
in cerebellar granule cells. CaMKs have numerous cellular functions and they influence processes as diverse
as gene transcription, cell survival, apoptosis, cytoskeletal re-organization and learning and memory.

Gene Wiki entry for CAMK2D


Genomic Views
for CAMK2D gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CAMK2D gene promoter:
         ER-alpha   TBP   CUTL1   FOXL1   Max   FAC1   HOXA5   FOXJ2 (long isoform)   FOXJ2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CAMK2D promoter sequence
   Search SABiosciences Chromatin IP Primers for CAMK2D

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAMK2D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q26   Ensembl cytogenetic band:  4q26   HGNC cytogenetic band: 4q26

CAMK2D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAMK2D gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M114372:  view genomic region     (about GC identifiers)

Start:
 114,372,188 bp from pter      End:
 114,683,083 bp from pter
Size:
 310,896 bases      Orientation:
 minus strand

Proteins
for CAMK2D gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KCC2D_HUMAN, Q13557 (See protein sequence)
Recommended Name: Calcium/calmodulin-dependent protein kinase type II subunit delta  
Size: 499 amino acids; 56369 Da
Subunit: CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D).
The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric
rings stacked one on top of the other. Interacts with RRAD and CACNB2 (By similarity)
Subcellular location: Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side (Probable). Sarcoplasmic
reticulum membrane; Peripheral membrane protein; Cytoplasmic side (Probable)
Miscellaneous: Expression of CAMK2D is significantly increased in patients suffering from dilated cardiomyopathy in
PubMed:10189359
Sequence caution: Sequence=BAD92525.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
4 PDB 3D structures from and Proteopedia for CAMK2D:
2VN9 (3D)        2W2C (3D)        2WEL (3D)        3GP2 (3D)    
Secondary accessions: A8MVS8 Q52PK4 Q59G21 Q8N553 Q9UGH6 Q9UQE9
Alternative splicing: 10 isoforms:  Q13557-1   Q13557-3   Q13557-4   Q13557-8   Q13557-9   Q13557-5   Q13557-6   Q13557-10   
Q13557-11   Q13557-12   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CAMK2D: NX_Q13557

Post-translational modifications:

  • Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase
    • into an activated state1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13557

    • 4/49 DME Specific Peptides for CAMK2D (Q13557) (see all 49)
     TEQLIEA  TTIEDED  YTKICDP  PEAKDLI 

    CAMK2D Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (6 alternative transcripts): 
    NP_001212.2  NP_742112.1  NP_742113.1  NP_742125.1  NP_742126.1  NP_742127.1  

    ENSEMBL proteins: 
     ENSP00000378032   ENSP00000424247   ENSP00000425824   ENSP00000339740   ENSP00000423482  
     ENSP00000423677   ENSP00000378030   ENSP00000424245   ENSP00000369098   ENSP00000422566  
     ENSP00000423753   ENSP00000415248   ENSP00000415707   ENSP00000406131   ENSP00000378034  
     ENSP00000296402  
    Reactome Protein details: Q13557
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant CAMK2D Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 3): CAMK2D
    OriGene Protein Over-expression Lysate (see all 4): CAMK2D
    OriGene Custom Protein Services for CAMK2D 
    GenScript Custom Purified and Recombinant Proteins Services for CAMK2D
    Novus Biologicals CAMK2D Proteins
    Novus Biologicals CAMK2D Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/14 cellular component terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--


    CAMK2D for ontologies           About GeneDecksing



    CAMK2D Antibody Products: 
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    Assay Products for CAMK2D: 
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for CAMK2D gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CAMK2D for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q13557

    ProtoNet protein and cluster: Q13557

    1 Blocks protein family: IPB013543 Calcium/calmodulin dependent protein kinase II

    UniProtKB/Swiss-Prot: KCC2D_HUMAN, Q13557
    Domain: The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for
    oligomerization
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for CAMK2D gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KCC2D_HUMAN, Q13557
    Function: Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and
    excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved
    in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and
    K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its
    activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac
    decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on
    'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to
    14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left
    ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of
    the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to
    myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+)
    channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3,
    which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor
    of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent
    acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the
    modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through
    phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves
    intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active
    form and confers to the kinase a Ca(2+)-independent activity
    Induction: Activity is induced in skeletal muscle during exercise

    Enzyme Numbers (IUBMB): EC 2.7.11.171 2 EC 2.7.112

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 6): CAMK2D
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAMK2D
    8/81 QIAGEN miScript miRNA Assays for microRNAs that regulate CAMK2D (see all 81):
    hsa-miR-607 hsa-miR-361-5p hsa-miR-3074-3p hsa-miR-30d hsa-miR-890 hsa-miR-30a hsa-miR-3150b-3p hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmid: CAMK2D 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAMK2D (see all 7)
    OriGene shRNA RFP: CAMK2D
    OriGene siRNA: CAMK2D
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAMK2D

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CAMK2D

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAMK2D (see all 10)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAMK2D (see all 10)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 6): CAMK2D (NM_172128)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAMK2D
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMK2D 

    Cell Line
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    Search LifeMap BioReagents cell lines for CAMK2D

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMK2D

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004683calmodulin-dependent protein kinase activity IEA--
    GO:0005515protein binding ----
    GO:0005516calmodulin binding IEA--
    GO:0005524ATP binding NAS--


    CAMK2D for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for CAMK2D:
     Decreased focal adhesion (FA)   Increased HPV18 LCR reporter a  Increased apoptosis  Increased cell death HMECs cel 
     Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Camk2dtm1.2Eno for CAMK2D
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Camk2d):
     cardiovascular system  homeostasis/metabolism  no phenotypic analysis 

    CAMK2D for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CAMK2D gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/53 super-pathways (see all 53) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development Angiotensin activation of ERK
    		Development Angiotensin activation of ERK1.00
    		Development_G-Proteins mediated regulation MARK-ERK signaling0.66
    		Development_Angiotensin activation of ERK0.98
    		Development G-Proteins mediated regulation MARK-ERK signaling0.66
    		Development_ACM2 and ACM4 activation of ERK0.74
    		Cholinergic synapse0.30
    		Development ACM2 and ACM4 activation of ERK0.74
    2Development_Endothelin-1/EDNRA transactivation of EGFR
    		Development_Endothelin-1/EDNRA transactivation of EGFR1.00
    		Development_Endothelin-1/EDNRA signaling0.41
    		Development Endothelin-1/EDNRA transactivation of EGFR1.00
    		Cytoskeleton remodeling_FAK signaling0.41
    		Development Endothelin-1/EDNRA signaling0.41
    		Cytoskeleton remodeling FAK signaling0.41
    3Translation_Translation regulation by Alpha-1 adrenergic receptors
    		Translation_Translation regulation by Alpha-1 adrenergic receptors1.00
    		Development_Activation of ERK by Alpha-1 adrenergic receptors0.64
    		Translation Translation regulation by Alpha-1 adrenergic receptors1.00
    		Development Activation of ERK by Alpha-1 adrenergic receptors0.64
    4Immune response_IFN gamma signaling pathway
    		Immune response_IFN gamma signaling pathway1.00
    		IFN-gamma pathway0.43
    		Immune response IFN gamma signaling pathway1.00
    5CREB phosphorylation through the activation of CaMKII
    		CREB phosphorylation through the activation of CaMKII1.00
    		Unblocking of NMDA receptor, glutamate binding and activation0.68
    		Ras activation uopn Ca2+ infux through NMDA receptor0.78

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/18 EMD Millipore Pathways for CAMK2D (see all 18)
        Translation Translation regulation by Alpha-1 adrenergic receptors
    Development Activation of ERK by Alpha-1 adrenergic receptors
    Cytoskeleton remodeling FAK signaling
    Signal transduction IP3 signaling
    Cell adhesion Integrin inside-out signaling

    1 R&D Systems Pathway for CAMK2D
        Wnt Signaling Pathway

    5/18 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CAMK2D (see all 18)
        Molecular Mechanisms of Cancer
    PI3K Signaling in B-Lymphocyte
    Melatonin Signaling
    IP3 Pathway
    CREB Pathway

    2 Cell Signaling Technology (CST) Pathways for CAMK2D
        Ca, cAMP and Lipid Signaling
    Neuroscience

    5/18 GeneGo (Thomson Reuters) Pathways for CAMK2D (see all 18)
        Development Endothelin-1/EDNRA transactivation of EGFR
    Signal transduction cAMP signaling
    Development Endothelin-1/EDNRA signaling
    Development Angiotensin signaling via PYK2
    Development Activation of ERK by Alpha-1 adrenergic receptors

    5/8 BioSystems Pathways for CAMK2D (see all 8) 
        Calcium Regulation in the Cardiac Cell
    SRF and miRs in Smooth Muscle Differentiation and Proliferation
    Myometrial Relaxation and Contraction Pathways
    MicroRNAs in cardiomyocyte hypertrophy
    TGF-beta Receptor Signaling Pathway

    5/15        Reactome Pathways for CAMK2D (see all 15)
        Ras activation uopn Ca2+ infux through NMDA receptor
    Interferon gamma signaling
    Unblocking of NMDA receptor, glutamate binding and activation
    CREB phosphorylation through the activation of CaMKII
    Cytokine Signaling in Immune system

    1 PharmGKB Pathway for CAMK2D
        EGFR Inhibitor Pathway, Pharmacodynamics

    5/13         Kegg Pathways  (Kegg details for CAMK2D) (see all 13):
        ErbB signaling pathway
    Calcium signaling pathway
    Oocyte meiosis
    Wnt signaling pathway
    Long-term potentiation


    CAMK2D for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CAMK2D

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/93 Interacting proteins for CAMK2D (Q135572, 3 ENSP000003397404) via UniProtKB, MINT, STRING, and/or I2D (see all 93)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IKBKGQ9Y6K92, 3MINT-48204 I2D: score=2 
    EIF4BP235882, 3, ENSP000002620564MINT-6538652 I2D: score=1 STRING: ENSP00000262056
    STIP1P319482, 3, ENSP000003059584MINT-6538664 I2D: score=1 STRING: ENSP00000305958
    CAMK2AQ9UQM73, ENSP000003814124I2D: score=2 STRING: ENSP00000381412
    CYLDQ9NQC73, ENSP000003089284I2D: score=2 STRING: ENSP00000308928
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IEA--
    GO:0001558regulation of cell growth NAS9060999
    GO:0002028regulation of sodium ion transport IEA--
    GO:0006468protein phosphorylation NAS--
    GO:0006816calcium ion transport IEA--


    CAMK2D for ontologies           About GeneDecksing



    Drugs & Compounds
    for CAMK2D gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CAMK2D for compounds           About GeneDecksing

    EMD Millipore small molecules for CAMK2D:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CAMK2D available from Tocris Bioscience    About this table
    CompoundAction CAS #
    KN-62Non-competitive P2X7 antagonist[127191-97-3]
    KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
    Autocamtide-2-related inhibitory peptideSelective CaM kinase II inhibitor[167114-91-2]
    Arcyriaflavin APotent cdk4/cyclin D1 and CaM Kinase II inhibitor. Antiviral agent (anti-HCMV)[118458-54-1]

    3 HMDB Compounds for CAMK2D    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--

    2 DrugBank Compounds for CAMK2D    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE-- --target--10592235
    [4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE-- --target--10592235

    1 Novoseek chemical compound relationship for CAMK2D gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 27.7 2 11451385 (1), 18486612 (1)

    Search CenterWatch for drugs/clinical trials and news about CAMK2D / KCC2D 

    Transcripts
    for CAMK2D gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CAMK2D gene (6 alternative transcripts): 
    NM_001221.3  NM_172114.1  NM_172115.2  NM_172127.2  NM_172128.2  NM_172129.1  

    Unigene Cluster for CAMK2D:

    Calcium/calmodulin-dependent protein kinase II delta
    Hs.144114  [show with all ESTs]
    Unigene Representative Sequence: NM_001221
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394524 ENST00000513132 ENST00000511664 ENST00000342666 ENST00000515496
    ENST00000514328 ENST00000394522 ENST00000505990 ENST00000379773 ENST00000508738
    ENST00000509594 ENST00000509907 ENST00000505132 ENST00000454265 ENST00000429180(uc003ibo.4)
    ENST00000418639 ENST00000394526(uc003ibi.3) ENST00000296402(uc003ibj.3 uc003ibk.3 uc003ibm.2 uc003ibn.2 uc003ibl.2)


    miRNA
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    8/81 QIAGEN miScript miRNA Assays for microRNAs that regulate CAMK2D (see all 81):
    hsa-miR-607 hsa-miR-361-5p hsa-miR-3074-3p hsa-miR-30d hsa-miR-890 hsa-miR-30a hsa-miR-3150b-3p hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmid: CAMK2D 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAMK2D (see all 7)
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 6): CAMK2D (NM_172128)
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    Additional cDNA sequence: 

    AB209288.1 AF071569.1 AJ252239.1 AK025368.1 AK055642.1 AK294517.1 AY987011.1 BC022558.1 
    BC032784.1 BX538071.1 BX647363.1 EF139846.1 U50361.1 U73738.1 

    19 DOTS entries:

    DT.454654  DT.318204  DT.312104  DT.100026499  DT.100787061  DT.121264415  DT.100787058  DT.100787059 
    DT.86846189  DT.95350739  DT.100753377  DT.97812745  DT.424214  DT.95373924  DT.75190472  DT.100712732 
    DT.91862551  DT.97795028  DT.97816747 

    24/385 AceView cDNA sequences (see all 385):

    AW630893 BM354204 AI432148 CB106867 W88760 AL120285 CA432186 AI432714 
    AA448956 AA811315 AI124777 AI057019 AK055642 AA777583 AA490727 AV655906 
    AA233206 BU785514 H42887 AL701498 CA412412 AA860658 AA777512 CF136256 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CAMK2D (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ·
    SP1:                                      -     -                             -                                                                                 
    SP2:                                      -     -                             -                                               -                             -   
    SP3:                                      -     -                             -                                               -                                 
    SP4:                                      -     -                       -                                                                                       
    SP5:                                                                                                                          -                                 

    ExUns: 20c · 20d ^ 21
    SP1:                  
    SP2:  -     -         
    SP3:                  
    SP4:                  
    SP5:  -     -         


    ECgene alternative splicing isoforms for CAMK2D

    Expression
    for CAMK2D gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CAMK2D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGACACTGTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CAMK2D expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor CellsSpinal Cord
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BrainMedulla OblongataBrain
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Spinal CordSpinal Dorsal ColumnsSpinal Cord
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CAMK2D Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CAMK2D

    SOURCE GeneReport for Unigene cluster: Hs.144114

    UniProtKB/Swiss-Prot: KCC2D_HUMAN, Q13557
    Tissue specificity: Expressed in cardiac muscle and skeletal muscle. Isoform Delta 3, isoform Delta 2, isoform Delta 8
    and isoform Delta 9 are expressed in cardiac muscle. Isoform Delta 11 is expressed in skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Arrays including CAMK2D: 
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    Primer
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    In Situ
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    Orthologs
    for CAMK2D gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CAMK2D gene from 7/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CAMK2D1 calcium/calmodulin-dependent protein kinase II delta 87.77(n)
    98.95(a)    		   422688  NM_001039300.1  NP_001034389.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CAMK2D6
    		 --
    		 77(a)
    		 1 ↔ 1
    		 5(142440945-142532674)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.6902 Xenopus laevis calcium/calmodulin-dependent protein more 83.93(n)    AF233629.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii camk2d21 calcium/calmodulin-dependent protein kinase (CaM kinase) more 78.03(n)
    91.74(a)    		   436815  NM_001002542.1  NP_001002542.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CaMKII1 , 3 learning and/or memory protein
    serine/threonine more3
    Calcium/calmodulin-dependent protein kinase II1    		 74(a)3
    70.23(n)1
    80.71(a)1    		   438281  NM_001169362.11  NP_001162833.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea unc-431 Protein UNC-43 64.76(n)
    72.03(a)    		   177921  NM_001028129.2  NP_001023300.1 
    rice
    (Oryza sativa)    		 Liliopsida Os11g01366001 hypothetical protein 45.89(n)
    37.68(a)    		   4349714  NM_001072223.1  NP_001065691.1 


    ENSEMBL Gene Tree for CAMK2D (if available)
    TreeFam Gene Tree for CAMK2D (if available) 

    Paralogs
    for CAMK2D gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CAMK2D gene
    PNCK2  CAMK1G2  PSKH22  DCX2  DCLK22  CAMK2A2  CAMK1D2  DCLK12  
    PSKH12  CAMK42  DCLK32  CAMKV2  CAMK2G2  CAMK2B2  CAMK12  
    18/92 SIMAP similar genes for CAMK2D using alignment to 7 protein entries:     KCC2D_HUMAN (see all proteins) (see all similar genes):
    CAMK2A    CAMK2B    CAMK2G    CASK    PNCK    DCLK3
    KIAA0999    DAPK3    CAMK1D    BRAF    DCLK1    PRKAA1
    RPS6KA1    CAMK1    PHKG2    CDK4    BRSK2    DKFZp564L2416

    CAMK2D for paralogs           About GeneDecksing



    Genomic Variants
    for CAMK2D gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CAMK2D
         1 CNV: 92319
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for CAMK2D

    Disorders / Diseases
    for CAMK2D gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CAMK2D for disorders           About GeneDecksing

    OMIM gene information: 607708    OMIM disorders: --

    18 diseases for CAMK2D:    About MalaCards
    reflex epilepsy    muscle hypertrophy    alcohol dependence    dilated cardiomyopathy
    epithelial ovarian cancer    myocardial infarction    kawasaki disease    down syndrome
    ovarian cancer    insulinoma    cardiomyopathy    alcoholism
    lung carcinoma    breast cancer    hypertension    tuberculosis
    carcinoma    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: CAMK2D (3 documents)

    Export disorders for CAMK2D gene to outside databases

    Publications
    for CAMK2D gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CAMK2D gene, integrated from 9 sources (see all 73):
    (articles sorted by number of sources associating them with CAMK2D)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of the CaMKIIdelta/calmodulin complex revea ls the molecular mechanism of CaMKII kinase activation. (PubMed id 20668654)1, 2 Rellos P....Knapp S. (2010)
    2. Cardiac ryanodine receptor phosphorylation by CaM Kin ase II: keeping the balance right. (PubMed id 19482609)1, 2 Currie S. (2009)
    3. Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart. (PubMed id 17157285)1, 2 Maier L.S. and Bers D.M. (2007)
    4. Nuclear calcium/calmodulin-dependent protein kinase IIdelta preferentially transmits signals to histone deacetylase 4 in cardiac cells. (PubMed id 17179159)1, 2 Little G.H....Poizat C. (2007)
    5. Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II. (PubMed id 14722083)1, 2 Gaertner T.R....Waxham M.N. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Cloning and quantitative determination of the human Ca2+/calmodulin- dependent protein kinase II (CaMK II) isoforms in human beta cells. (PubMed id 10819240)1, 2 Rochlitz H.... Pfeiffer A.F. (2000)
    9. Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium. (PubMed id 10189359)1, 2 Hoch B.... Karczewski P. (1999)
    10. Identification of novel human tumor cell-specific CaMK-II variants. (PubMed id 9060999)1, 2 Tombes R.M. and Krystal G.W. (1997)

    External Searches for CAMK2D gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CAMK2D gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 817 HGNC: 1462 AceView: CAMK2D Ensembl:ENSG00000145349 euGenes: HUgn817
    ECgene: CAMK2D Kegg: 817 H-InvDB: CAMK2D

    Other Databases showing CAMK2D gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CAMK2D gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CAMK2D Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CAMK2D gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CAMK2D gene:
    Search GeneIP for patents involving CAMK2D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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