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Aliases for CAMK2D Gene

Aliases for CAMK2D Gene

  • Calcium/Calmodulin Dependent Protein Kinase II Delta 2 3 5
  • Calcium/Calmodulin-Dependent Protein Kinase (CaM Kinase) II Delta 2 3
  • CaM Kinase II Subunit Delta 3 4
  • CaMK-II Subunit Delta 3 4
  • EC 2.7.11.17 4 61
  • CAMKD 3 4
  • Calcium/Calmodulin-Dependent Protein Kinase Type II Subunit Delta 3
  • Calcium/Calmodulin-Dependent Protein Kinase Type II Delta Chain 3
  • CaM Kinase II Delta Subunit 3
  • CaM-Kinase II Delta Chain 3
  • CaMK-II Delta Subunit 3
  • EC 2.7.11 61

External Ids for CAMK2D Gene

Previous HGNC Symbols for CAMK2D Gene

  • CAMKD

Previous GeneCards Identifiers for CAMK2D Gene

  • GC04M114789
  • GC04M114655
  • GC04M114832
  • GC04M114731
  • GC04M114372
  • GC04M110100

Summaries for CAMK2D Gene

Entrez Gene Summary for CAMK2D Gene

  • The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.[provided by RefSeq, Nov 2008]

GeneCards Summary for CAMK2D Gene

CAMK2D (Calcium/Calmodulin Dependent Protein Kinase II Delta) is a Protein Coding gene. Diseases associated with CAMK2D include Dilated Cardiomyopathy and Cardiomyopathy. Among its related pathways are Interferon gamma signaling and RET signaling. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is CAMK2B.

UniProtKB/Swiss-Prot for CAMK2D Gene

  • Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on Ser-2808. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor.

Tocris Summary for CAMK2D Gene

  • Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through autoinhibition, which can be relieved by increases in Ca2+ levels.

Gene Wiki entry for CAMK2D Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMK2D Gene

Genomics for CAMK2D Gene

Regulatory Elements for CAMK2D Gene

Enhancers for CAMK2D Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F113676 1.2 Ensembl ENCODE 12 +85.1 85068 1.7 PKNOX1 KLF17 FEZF1 ZNF2 ZEB1 ZNF335 GLIS2 ZNF366 KLF7 EGR2 CAMK2D GC04P113683 GC04M113521
GH04F113635 1.5 FANTOM5 Ensembl ENCODE 8.9 +123.1 123076 7.4 HDGF ELF3 TBP CBX3 ATF1 ARID4B YBX1 FEZF1 ZSCAN9 RAD21 CAMK2D GC04P113683 GC04M113521
GH04F113757 1.1 ENCODE 10 +1.5 1520 6.8 HDGF PKNOX1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 CAMK2D CIR1P2 GC04P113708
GH04F113644 1.2 Ensembl ENCODE 8.2 +116.0 116012 2.5 ELF3 KLF17 FEZF1 ETS1 RARA YY1 FOS CREM TSHZ1 ZNF843 CAMK2D GC04P113683 GC04M113521
GH04F113695 1.1 Ensembl ENCODE 6.5 +66.1 66075 1.5 KLF1 NFRKB INSM2 FEZF1 HIC1 ZNF664 ZFHX2 ZBTB48 PATZ1 FOS CAMK2D GC04P113683 GC04P113708
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CAMK2D on UCSC Golden Path with GeneCards custom track

Promoters for CAMK2D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001247741 1433 5401 HDGF PKNOX1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for CAMK2D Gene

Chromosome:
4
Start:
113,451,032 bp from pter
End:
113,762,133 bp from pter
Size:
311,102 bases
Orientation:
Minus strand

Genomic View for CAMK2D Gene

Genes around CAMK2D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAMK2D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAMK2D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMK2D Gene

Proteins for CAMK2D Gene

  • Protein details for CAMK2D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13557-KCC2D_HUMAN
    Recommended name:
    Calcium/calmodulin-dependent protein kinase type II subunit delta
    Protein Accession:
    Q13557
    Secondary Accessions:
    • A8MVS8
    • Q52PK4
    • Q59G21
    • Q8N553
    • Q9UGH6
    • Q9UQE9

    Protein attributes for CAMK2D Gene

    Size:
    499 amino acids
    Molecular mass:
    56369 Da
    Quaternary structure:
    • CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other. Interacts with RRAD and CACNB2 (By similarity).
    Miscellaneous:
    • Expression of CAMK2D is significantly increased in patients suffering from dilated cardiomyopathy in PubMed:10189359.
    SequenceCaution:
    • Sequence=BAD92525.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CAMK2D Gene

    Alternative splice isoforms for CAMK2D Gene

neXtProt entry for CAMK2D Gene

Selected DME Specific Peptides for CAMK2D Gene

Q13557:
  • WACGVILYILLVGYPPFWDEDQH
  • TVASMMHRQETV
  • YTKICDP
  • NNGDFEAY
  • CLKKFNARRKLKGAILTT
  • CTRFTDEYQL
  • KGAAVKLADFGLAIEV
  • NIVRLHD
  • HYLVFDLVTGGELFEDIVARE
  • GVILYIL
  • HTIILNPHVHL
  • FPSPEWD
  • KKPDGVK
  • RNFSAAKSLL
  • QAWFGFAGTPGYLSPEVL
  • WACGVIL
  • LIEAINNG
  • FEPEALGNLVEG
  • QILESVNH
  • VHRDLKPENLLLASK
  • VKLADFG
  • VTGGELF
  • YSEADASHCIQQILE
  • TEQLIEA
  • MLTINPAKRI
  • QIKAGAYD
  • EALKHPWI
  • TTIEDED
  • PEAKDLI
  • PYGKPVD
  • LADFGLA
  • QSEETRVWH
  • DGKWQNVHFH
  • DAACIAYIRLTQY
  • DFHRFYFEN
  • RKQEIIK
  • LKPENLL
  • RDLKPEN
  • GKGAFSVVRRC
  • AAKIINTKKL
  • TCTRFTD
  • EELGKGAFS
  • FNARRKL
  • RITASEAL
  • NIVRLHDSISEEG
  • QKLEREARICR
  • VHRDLKP
  • GKPVDMW
  • IVHRDLK

Post-translational modifications for CAMK2D Gene

  • Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.
  • Ubiquitination at Lys 251
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for CAMK2D (CaM Kinase II delta)
  • Cell Signaling Technology (CST) Antibodies for CAMK2D (CAMK2D)

Domains & Families for CAMK2D Gene

Suggested Antigen Peptide Sequences for CAMK2D Gene

Graphical View of Domain Structure for InterPro Entry

Q13557

UniProtKB/Swiss-Prot:

KCC2D_HUMAN :
  • The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Domain:
  • The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
genes like me logo Genes that share domains with CAMK2D: view

Function for CAMK2D Gene

Molecular function for CAMK2D Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity.
UniProtKB/Swiss-Prot Function:
Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on Ser-2808. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor.
UniProtKB/Swiss-Prot Induction:
Activity is induced in skeletal muscle during exercise.

Enzyme Numbers (IUBMB) for CAMK2D Gene

Gene Ontology (GO) - Molecular Function for CAMK2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004683 calmodulin-dependent protein kinase activity IDA 22514276
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
genes like me logo Genes that share ontologies with CAMK2D: view
genes like me logo Genes that share phenotypes with CAMK2D: view

Animal Models for CAMK2D Gene

MGI Knock Outs for CAMK2D:

Animal Model Products

  • Taconic Biosciences Mouse Models for CAMK2D

miRNA for CAMK2D Gene

miRTarBase miRNAs that target CAMK2D

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAMK2D Gene

Localization for CAMK2D Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMK2D Gene

Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAMK2D gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
endoplasmic reticulum 4

Gene Ontology (GO) - Cellular Components for CAMK2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS 12676814
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS 12676814
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with CAMK2D: view

Pathways & Interactions for CAMK2D Gene

SuperPathways for CAMK2D Gene

SuperPathway Contained pathways
1 RET signaling
2 Post NMDA receptor activation events
3 Development Angiotensin activation of ERK
4 Development Endothelin-1/EDNRA signaling
5 Cardiac conduction
genes like me logo Genes that share pathways with CAMK2D: view

Pathways by source for CAMK2D Gene

SIGNOR curated interactions for CAMK2D Gene

Activates:
Inactivates:
Other effect:

Gene Ontology (GO) - Biological Process for CAMK2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IEA --
GO:0000165 MAPK cascade TAS --
GO:0001558 regulation of cell growth NAS 9060999
GO:0001666 response to hypoxia IEA --
GO:0002026 regulation of the force of heart contraction TAS 23283722
genes like me logo Genes that share ontologies with CAMK2D: view

Drugs & Compounds for CAMK2D Gene

(13) Drugs for CAMK2D Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
(3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE Experimental Pharma Target 0
[4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE Experimental Pharma Target 0
KN-93 Phosphate Pharma CaM kinase II inhibitor, water soluble and cell permeable, CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278). 0
calcium Nutra 0

(3) Additional Compounds for CAMK2D Gene - From: Tocris and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Autocamtide-2-related inhibitory peptide, myristoylated
201422-04-0
KN 93
139298-40-1

(5) Tocris Compounds for CAMK2D Gene

Compound Action Cas Number
A 484954 CaM kinase III (eEF-2 kinase) inhibitor 142557-61-7
Autocamtide-2-related inhibitory peptide, myristoylated CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptide 201422-04-0
KN 93 CaM kinase II inhibitor; also K+ channel blocker (KV) 139298-40-1
KN 93 phosphate CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278). 1188890-41-6
STO-609 acetate Selective CaM kinase kinase inhibitor 1173022-21-3

(7) ApexBio Compounds for CAMK2D Gene

Compound Action Cas Number
CaMKII-IN-1 1208123-85-6
KN-62 CaM kinase II inhibitor 127191-97-3
KN-92 CaMKII inhibitor 176708-42-2
KN-92 phosphate CaMKII inhibitor 1135280-28-2
KN-93 CaMKII inhibitor,selective and cometitive 139298-40-1
KN-93 hydrochloride CaMK II inhibitor
KN-93 Phosphate CaM kinase II inhibitor, water soluble and cell permeable 1188890-41-6
genes like me logo Genes that share compounds with CAMK2D: view

Transcripts for CAMK2D Gene

Unigene Clusters for CAMK2D Gene

Calcium/calmodulin-dependent protein kinase II delta:
Representative Sequences:

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAMK2D Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ·
SP1: - - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: -
SP6: -
SP7:

ExUns: 20c · 20d ^ 21
SP1:
SP2: - -
SP3:
SP4:
SP5: - -
SP6:
SP7:

Relevant External Links for CAMK2D Gene

GeneLoc Exon Structure for
CAMK2D
ECgene alternative splicing isoforms for
CAMK2D

Expression for CAMK2D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CAMK2D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CAMK2D Gene

This gene is overexpressed in Brain (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CAMK2D Gene



Protein tissue co-expression partners for CAMK2D Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CAMK2D Gene:

CAMK2D

SOURCE GeneReport for Unigene cluster for CAMK2D Gene:

Hs.144114

mRNA Expression by UniProt/SwissProt for CAMK2D Gene:

Q13557-KCC2D_HUMAN
Tissue specificity: Expressed in cardiac muscle and skeletal muscle. Isoform Delta 3, isoform Delta 2, isoform Delta 8 and isoform Delta 9 are expressed in cardiac muscle. Isoform Delta 11 is expressed in skeletal muscle.
genes like me logo Genes that share expression patterns with CAMK2D: view

No data available for mRNA differential expression in normal tissues for CAMK2D Gene

Orthologs for CAMK2D Gene

This gene was present in the common ancestor of animals.

Orthologs for CAMK2D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAMK2D 34 35
  • 99.73 (n)
oppossum
(Monodelphis domestica)
Mammalia CAMK2D 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CAMK2D 34 35
  • 95.17 (n)
dog
(Canis familiaris)
Mammalia CAMK2D 34 35
  • 94.86 (n)
rat
(Rattus norvegicus)
Mammalia Camk2d 34
  • 92.45 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CAMK2D 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Camk2d 34 16 35
  • 91.45 (n)
chicken
(Gallus gallus)
Aves CAMK2D 34 35
  • 87.77 (n)
lizard
(Anolis carolinensis)
Reptilia CAMK2D 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia camk2d 34
  • 84.14 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.690 34
zebrafish
(Danio rerio)
Actinopterygii camk2d2 35
  • 80 (a)
OneToOne
camk2d1 34
  • 77.75 (n)
fruit fly
(Drosophila melanogaster)
Insecta CaMKII 36 34 35
  • 70.39 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000028 34
  • 65.75 (n)
worm
(Caenorhabditis elegans)
Secernentea unc-43 34 35
  • 65.53 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8584 34
Species where no ortholog for CAMK2D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAMK2D Gene

ENSEMBL:
Gene Tree for CAMK2D (if available)
TreeFam:
Gene Tree for CAMK2D (if available)

Paralogs for CAMK2D Gene

Paralogs for CAMK2D Gene

genes like me logo Genes that share paralogs with CAMK2D: view

Variants for CAMK2D Gene

Sequence variations from dbSNP and Humsavar for CAMK2D Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10000007 -- 113,632,097(+) ATTAT(A/C)CAATC intron-variant
rs10000775 -- 113,625,533(+) gaaga(C/T)catat intron-variant
rs10001376 -- 113,567,469(+) GGCCA(A/G)CTGAG intron-variant
rs10001443 -- 113,641,235(+) TAGAG(C/T)AGAAA intron-variant
rs10001541 -- 113,507,453(+) tagta(A/G)agatg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAMK2D Gene

Variant ID Type Subtype PubMed ID
nsv950382 CNV duplication 24416366
nsv950381 CNV duplication 24416366
nsv830038 CNV gain 17160897
nsv595183 CNV loss 21841781
nsv525087 CNV gain 19592680
nsv507189 OTHER sequence alteration 20534489
nsv474651 CNV novel sequence insertion 20440878
nsv4475 CNV deletion 18451855
nsv4474 CNV insertion 18451855
esv3601817 CNV gain 21293372
esv3601816 CNV gain 21293372
esv3601813 CNV loss 21293372
esv3564461 CNV deletion 23714750
esv3344069 CNV insertion 20981092
esv3340807 CNV insertion 20981092
esv3305937 CNV mobile element insertion 20981092
esv3303071 CNV tandem duplication 20981092
esv2677203 CNV deletion 23128226

Variation tolerance for CAMK2D Gene

Residual Variation Intolerance Score: 14.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.53; 44.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAMK2D Gene

Human Gene Mutation Database (HGMD)
CAMK2D
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAMK2D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMK2D Gene

Disorders for CAMK2D Gene

MalaCards: The human disease database

(2) MalaCards diseases for CAMK2D Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
dilated cardiomyopathy
  • congestive cardiomyopathy
cardiomyopathy
  • cardiomyopathies
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CAMK2D

Genetic Association Database (GAD)
CAMK2D
Human Genome Epidemiology (HuGE) Navigator
CAMK2D
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAMK2D
genes like me logo Genes that share disorders with CAMK2D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAMK2D Gene

Publications for CAMK2D Gene

  1. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G. … Riley B.P. (Hum. Mol. Genet. 2010) 3 46 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation. (PMID: 20668654) Rellos P. … Knapp S. (PLoS Biol. 2010) 3 4 64
  4. A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease. (PMID: 19132087) Burgner D. … Hibberd M.L. (PLoS Genet. 2009) 3 46 64
  5. Cardiac ryanodine receptor phosphorylation by CaM Kinase II: keeping the balance right. (PMID: 19482609) Currie S. (Front. Biosci. 2009) 3 4 64

Products for CAMK2D Gene

Sources for CAMK2D Gene

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