Aliases for CAMK2D Gene
Aliases for CAMK2D Gene
External Ids for CAMK2D Gene
- HGNC: 1462
- Entrez Gene: 817
- Ensembl: ENSG00000145349
- OMIM: 607708
- UniProtKB: Q13557
Previous HGNC Symbols for CAMK2D Gene
- CAMKD
Previous GeneCards Identifiers for CAMK2D Gene
- GC04M114789
- GC04M114655
- GC04M114832
- GC04M114731
- GC04M114372
- GC04M110100
Summaries for CAMK2D Gene
-
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.[provided by RefSeq, Nov 2008]
GeneCards Summary for CAMK2D Gene
CAMK2D (Calcium/Calmodulin Dependent Protein Kinase II Delta) is a Protein Coding gene. Diseases associated with CAMK2D include Dilated Cardiomyopathy and Cardiomyopathy. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and Development Endothelin-1/EDNRA signaling. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is CAMK2B.
UniProtKB/Swiss-Prot for CAMK2D Gene
-
Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on Ser-2808. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor.
-
Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through autoinhibition, which can be relieved by increases in Ca2+ levels.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMK2D Gene
Genomics for CAMK2D Gene
Regulatory Elements for CAMK2D Gene
Enhancers for CAMK2D Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH04G113755 | 1.6 | Ensembl ENCODE dbSUPER | 9.9 | +2.3 | 2335 | 8.4 | HDGF PKNOX1 FOXA2 MLX ZFP64 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 | CAMK2D CIR1P2 GC04P113708 |
| GH04G113677 | 1.2 | ENCODE dbSUPER | 12 | +84.7 | 84704 | 1.0 | PKNOX1 KLF17 INSM2 FEZF1 ZNF2 ZEB1 ZNF335 GLIS2 ZNF366 EGR1 | CAMK2D GC04P113683 GC04M113521 |
| GH04G113639 | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 8.4 | +121.2 | 121197 | 3.6 | ELF3 TBP FOXA2 ATF1 ZSCAN9 RAD21 ZBTB40 RELB CREM PPARG | CAMK2D GC04P113683 GC04M113521 |
| GH04G113635 | 1.4 | Ensembl ENCODE dbSUPER | 8.7 | +125.1 | 125125 | 3.3 | ELF3 HDGF CBX3 ARID4B FEZF1 YBX1 ZBTB7B RAD21 GATA2 ZSCAN5C | CAMK2D GC04P113683 GC04M113521 |
| GH04G113644 | 1.4 | Ensembl ENCODE dbSUPER | 8.2 | +116.0 | 116012 | 2.5 | ELF3 FOXA2 KLF17 FEZF1 RARA YY1 ETS1 GATA2 FOS CREM | CAMK2D GC04P113683 GC04M113521 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CAMK2D on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CAMK2D gene promoter:
Regulatory Element Products
Genomic Location for CAMK2D Gene
- Chromosome:
- 4
- Start:
- 113,451,032 bp from pter
- End:
- 113,762,133 bp from pter
- Size:
- 311,102 bases
- Orientation:
- Minus strand
Genomic View for CAMK2D Gene
Genes around CAMK2D on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q26 by Ensembl
- 4q26 by Entrez Gene
- 4q26 by HGNC
CAMK2D Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CAMK2D Gene
Proteins for CAMK2D Gene
-
Protein details for CAMK2D Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13557-KCC2D_HUMAN
- Recommended name:
- Calcium/calmodulin-dependent protein kinase type II subunit delta
- Protein Accession:
- Q13557
- A8MVS8
- Q52PK4
- Q59G21
- Q8N553
- Q9UGH6
- Q9UQE9
Protein attributes for CAMK2D Gene
- Size:
- 499 amino acids
- Molecular mass:
- 56369 Da
- Quaternary structure:
-
- CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other. Interacts with RRAD and CACNB2 (By similarity).
- Miscellaneous:
-
- Expression of CAMK2D is significantly increased in patients suffering from dilated cardiomyopathy in PubMed:10189359.
- SequenceCaution:
-
- Sequence=BAD92525.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for CAMK2D Gene
Protein Expression for CAMK2D Gene
Selected DME Specific Peptides for CAMK2D Gene
- Q13557:
-
- WACGVILYILLVGYPPFWDEDQH
- TVASMMHRQETV
- YTKICDP
- NNGDFEAY
- CLKKFNARRKLKGAILTT
- CTRFTDEYQL
- KGAAVKLADFGLAIEV
- NIVRLHD
- HYLVFDLVTGGELFEDIVARE
- GVILYIL
- HTIILNPHVHL
- FPSPEWD
- KKPDGVK
- RNFSAAKSLL
- QAWFGFAGTPGYLSPEVL
- WACGVIL
- LIEAINNG
- FEPEALGNLVEG
- QILESVNH
- VHRDLKPENLLLASK
- VKLADFG
- VTGGELF
- YSEADASHCIQQILE
- TEQLIEA
- MLTINPAKRI
- QIKAGAYD
- EALKHPWI
- TTIEDED
- PEAKDLI
- PYGKPVD
- LADFGLA
- QSEETRVWH
- DGKWQNVHFH
- DAACIAYIRLTQY
- DFHRFYFEN
- RKQEIIK
- LKPENLL
- RDLKPEN
- GKGAFSVVRRC
- AAKIINTKKL
- TCTRFTD
- EELGKGAFS
- FNARRKL
- RITASEAL
- NIVRLHDSISEEG
- QKLEREARICR
- VHRDLKP
- GKPVDMW
- IVHRDLK
Post-translational modifications for CAMK2D Gene
- Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.
- Ubiquitination at posLast=251251
- Modification sites at PhosphoSitePlus
Other Protein References for CAMK2D Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- NP_001212.2
- NP_001308495.1
- NP_001308496.1
- NP_001308497.1
- NP_001308498.1
- NP_001308499.1
- NP_001308500.1
- NP_001308501.1
- NP_001308502.1
- NP_001308503.1
- NP_001308504.1
- NP_001308505.1
- NP_001308506.1
- NP_001308507.1
- NP_001308508.1
- NP_001308509.1
- NP_001308510.1
- NP_001308511.1
- NP_001308512.1
- NP_001308513.1
- NP_001308514.1
- NP_001308515.1
- NP_001308516.1
- NP_001308517.1
- NP_001308518.1
- NP_001308519.1
- NP_001308520.1
- NP_001308521.1
- NP_742112.1
- NP_742113.1
- NP_742125.1
- NP_742126.1
- NP_742127.1
- XP_005263310.1
- XP_005263311.1
- XP_006714393.1
- XP_011530591.1
- XP_011530592.1
- XP_011530593.1
- XP_011530594.1
- XP_011530597.1
- XP_016864161.1
- XP_016864162.1
- XP_016864163.1
- XP_016864164.1
- XP_016864165.1
- XP_016864166.1
- XP_016864167.1
Antibody Products
- R&D Systems Antibodies for CAMK2D (CaM Kinase II delta)
- Cell Signaling Technology (CST) Antibodies for CAMK2D (CAMK2D)
-
Custom Antibody ServicesOriGene Antibodies for CAMK2D
- Novus Biologicals Antibodies for CAMK2D
- Invitrogen Antibodies for CAMK2D
- antibodies-online Antibodies for CAMK2D: See all 82
- GeneTex CAMK2D antibody for CAMK2D
-
Santa Cruz Biotechnology (SCBT) Antibodies for CAMK2D
Protein Products
- EMD Millipore Purified and/or Recombinant CAMK2D Protein
- Search Origene for MassSpec and Protein Over-expression Lysates for CAMK2D
- Origene Custom Protein Services for CAMK2D
- antibodies-online Proteins for CAMK2D: See all 14
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CAMK2D
Assay Products
- antibodies-online Kits for CAMK2D: See all 6
Domains & Families for CAMK2D Gene
Gene Families for CAMK2D Gene
Protein Domains for CAMK2D Gene
Suggested Antigen Peptide Sequences for CAMK2D Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q13557UniProtKB/Swiss-Prot:
KCC2D_HUMAN :- The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.
- Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
- Domain:
-
- The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.
- Family:
-
- Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Function for CAMK2D Gene
Molecular function for CAMK2D Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity.
- UniProtKB/Swiss-Prot Function:
- Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on Ser-2808. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor.
- UniProtKB/Swiss-Prot Induction:
- Activity is induced in skeletal muscle during exercise.
Enzyme Numbers (IUBMB) for CAMK2D Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | TAS | -- |
| GO:0004683 | calmodulin-dependent protein kinase activity | IDA | 22514276 |
| GO:0005088 | Ras guanyl-nucleotide exchange factor activity | TAS | -- |
Phenotypes for CAMK2D Gene
- MGI mutant phenotypes for CAMK2D:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for CAMK2D:
-
- Increased vaccinia virus (VACV) infection
- Synthetic lethal with Ras
- Increased transferrin (TF) endocytosis
- Transferrin accumulation in the perinuclear area
- Decreased viability
- Decreased vesicular stomatitis virus (VSV) infection
- Increased HPV18 LCR reporter activity
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Increased cell death HMECs cells
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased cell viability after pRB stimulation
- Decreased cell proliferation
- Apoptosis resistance
- Increased senescence-associated beta-galactosidase protein expression after pRB stimulation
- Increased simian virus 40 (SV40) infection
- Decreased Cdk9 T-loop phosphorylation
Animal Model Products
-
Taconic Biosciences Mouse Models for CAMK2D
- Cyagen custom Knockout/knockin (KOKI) mouse models for CAMK2D
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CAMK2D gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CAMK2D gene
- Search ViGene Biosciences for CAMK2D
CRISPR Products
-
OriGene CRISPR knockouts for CAMK2D
-
Santa Cruz Biotechnology (SCBT) CRISPR for CAMK2D
- GenScript: Design CRISPR guide RNA sequences for CAMK2D
miRNA for CAMK2D Gene
- miRTarBase miRNAs that target CAMK2D
miRNA Products
- Search ViGene Biosciences for CAMK2D
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for CAMK2D
- Browse OriGene Inhibitory RNA Products For CAMK2D
-
ViGene Biosciences ready-to-package AAV shRNAs for CAMK2D gene
Clone Products
-
OriGene ORF clones in human for CAMK2D
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
-
GenScript: Next-day shipping cDNA ORF clone for CAMK2D in any vector
- NM_172129
- NM_172115
- NM_172114
- NM_172127
- NM_172128
- NM_001221
- XM_011532296
- XM_011532295
- XM_011532294
- XM_011532293
- XM_011532292
- XM_006714330
- XM_011532291
- XM_006714329
- XM_005263251
- XM_005263252
- XM_005263253
- XM_005263254
- XM_005263255
- XM_005263258
- XM_005263256
- XM_005263257
- XM_011532289
- XM_011532290
- XM_005263260
- XM_005263261
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CAMK2D
- VectorBuilder custom plasmid, inducible vectors for CAMK2D
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CAMK2D
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CAMK2D
-
ViGene Biosciences adenoviral particle packaged cDNA for CAMK2D gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CAMK2D gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CAMK2D gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAMK2D Gene
Localization for CAMK2D Gene
Subcellular locations from UniProtKB/Swiss-Prot for CAMK2D Gene
- Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 4 |
| endoplasmic reticulum | 4 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | ISS | 12676814 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | ISS | 12676814 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | TAS | -- |
Pathways & Interactions for CAMK2D Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Post NMDA receptor activation events | ||
| 3 | Development Angiotensin activation of ERK | ||
| 4 | Development Endothelin-1/EDNRA signaling | ||
| 5 | Cardiac conduction |
.39
|
|
Pathways by source for CAMK2D Gene
1 GeneTex pathway for CAMK2D Gene
2 Cell Signaling Technology pathways for CAMK2D Gene
8 BioSystems pathways for CAMK2D Gene
69 Reactome pathways for CAMK2D Gene
1 PharmGKB pathway for CAMK2D Gene
26 KEGG pathways for CAMK2D Gene
18 GeneGo (Thomson Reuters) pathways for CAMK2D Gene
4 R&D Systems pathways for CAMK2D Gene
18 Qiagen pathways for CAMK2D Gene
Interacting Proteins for CAMK2D Gene
Selected Interacting proteins:
ENSP00000339740
Q13557-KCC2D_HUMAN
for CAMK2D Gene via
STRING
MINT
UniProtKB
IID
SIGNOR curated interactions for CAMK2D Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0001558 | regulation of cell growth | NAS | 9060999 |
| GO:0001666 | response to hypoxia | IEA | -- |
| GO:0002026 | regulation of the force of heart contraction | TAS | 23283722 |
| GO:0002028 | regulation of sodium ion transport | IEA | -- |
Drugs & Compounds for CAMK2D Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Adenosine triphosphate | Approved | Nutra | 0 | |||
| (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE | Experimental | Pharma | Target | 0 | ||
| [4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE | Experimental | Pharma | Target | 0 | ||
| KN-93 Phosphate | Pharma | CaM kinase II inhibitor, water soluble and cell permeable, CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278). | 0 | |||
| calcium | Nutra | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
||
| Autocamtide-2-related inhibitory peptide, myristoylated |
|
201422-04-0 |
|
|
||
| KN 93 |
|
139298-40-1 |
|
|
(5) Tocris Compounds for CAMK2D Gene
| Compound | Action | Cas Number |
|---|---|---|
| A 484954 | CaM kinase III (eEF-2 kinase) inhibitor | 142557-61-7 |
| Autocamtide-2-related inhibitory peptide, myristoylated | CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptide | 201422-04-0 |
| KN 93 | CaM kinase II inhibitor; also K+ channel blocker (KV) | 139298-40-1 |
| KN 93 phosphate | CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278). | 1188890-41-6 |
| STO-609 acetate | Selective CaM kinase kinase inhibitor | 1173022-21-3 |
(7) ApexBio Compounds for CAMK2D Gene
| Compound | Action | Cas Number |
|---|---|---|
| CaMKII-IN-1 | 1208123-85-6 | |
| KN-62 | CaM kinase II inhibitor | 127191-97-3 |
| KN-92 | CaMKII inhibitor | 176708-42-2 |
| KN-92 phosphate | CaMKII inhibitor | 1135280-28-2 |
| KN-93 | CaMKII inhibitor,selective and cometitive | 139298-40-1 |
| KN-93 hydrochloride | CaMK II inhibitor | |
| KN-93 Phosphate | CaM kinase II inhibitor, water soluble and cell permeable | 1188890-41-6 |
Drug Products
- ApexBio compounds for CAMK2D
Transcripts for CAMK2D Gene
mRNA/cDNA for CAMK2D Gene
- (48) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (385) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CAMK2D Gene
CRISPR Products
-
OriGene CRISPR knockouts for CAMK2D
-
Santa Cruz Biotechnology (SCBT) CRISPR for CAMK2D
- GenScript: Design CRISPR guide RNA sequences for CAMK2D
miRNA Products
- Search ViGene Biosciences for CAMK2D
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for CAMK2D
- Browse OriGene Inhibitory RNA Products For CAMK2D
-
ViGene Biosciences ready-to-package AAV shRNAs for CAMK2D gene
Clone Products
-
OriGene ORF clones in human for CAMK2D
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
-
GenScript: Next-day shipping cDNA ORF clone for CAMK2D in any vector
- NM_172129
- NM_172115
- NM_172114
- NM_172127
- NM_172128
- NM_001221
- XM_011532296
- XM_011532295
- XM_011532294
- XM_011532293
- XM_011532292
- XM_006714330
- XM_011532291
- XM_006714329
- XM_005263251
- XM_005263252
- XM_005263253
- XM_005263254
- XM_005263255
- XM_005263258
- XM_005263256
- XM_005263257
- XM_011532289
- XM_011532290
- XM_005263260
- XM_005263261
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CAMK2D
- VectorBuilder custom plasmid, inducible vectors for CAMK2D
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CAMK2D
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: |
| ExUns: | 20c | · | 20d | ^ | 21 |
|---|---|---|---|---|---|
| SP1: | |||||
| SP2: | - | - | |||
| SP3: | |||||
| SP4: | |||||
| SP5: | - | - | |||
| SP6: | |||||
| SP7: |
Expression for CAMK2D Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
- Brain (Nervous System)
-
Blood (Hematopoietic System)
- Small Pre B-Cells Hematopoietic Bone Marrow
- Adipose (Muscoskeletal System)
This gene is overexpressed in Brain (20.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CAMK2D Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CAMK2D Gene:
CAMK2DSOURCE GeneReport for Unigene cluster for CAMK2D Gene:
Hs.144114mRNA Expression by UniProt/SwissProt for CAMK2D Gene:
Q13557-KCC2D_HUMAN
Tissue specificity:
Expressed in cardiac muscle and skeletal muscle. Isoform Delta 3, isoform Delta 2, isoform Delta 8 and isoform Delta 9 are expressed in cardiac muscle. Isoform Delta 11 is expressed in skeletal muscle.
Evidence on tissue expression from TISSUES for CAMK2D Gene
- Muscle(4.8)
- Nervous system(4.8)
- Heart(4.5)
- Liver(4.2)
Primer Products
-
OriGene qPCR primer pairs for CAMK2D
-
OriGene qPCR primer pairs and template standards for CAMK2D
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAMK2D Gene
Orthologs for CAMK2D Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CAMK2D 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CAMK2D 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CAMK2D 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CAMK2D 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Camk2d 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | CAMK2D 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Camk2d 34 16 35 |
|
||
| chicken (Gallus gallus) |
Aves | CAMK2D 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CAMK2D 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | camk2d 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.690 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | camk2d2 35 |
|
OneToOne | |
| camk2d1 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CaMKII 36 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000028 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | unc-43 34 35 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.8584 34 |
|
- Species where no ortholog for CAMK2D was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CAMK2D Gene
Paralogs for CAMK2D Gene
(91) SIMAP similar genes for CAMK2D Gene using alignment to 7 proteins:
- CAMK2A
- CAMK2B
- CAMK2G
- CASK
- PNCK
- DCLK3
- KIAA0999
- DAPK3
- CAMK1D
- RPS6KA1
- PRKAA1
- DCLK1
- BRAF
- CAMK1
- PHKG2
- CDK4
- DKFZp564L2416
- RPS6KA5
- BRSK2
- PHKG1
- STK17A
- PSKH1
- MGC45428
- CAMK4
- DAPK1
- CCRK
- TRIB2
- TRIB1
- STK11
- PKN2
- HUNK
- RPS6KA6
- Par1b
- MYLK4
- MYLK
- MARK2
- DCLK2
- PRKD2
- RPS6KA3
- RPS6KA2
- STK32A
- MYO3A
- PRKAA2
- CHEK2
- CHEK1
- CAMKV
- PSKH2
- DAPK2
- PRKY
- MARK3
- TTN
- SIK3
- MYLK3
- MARK1
- AURKB
- MAPKAPK3
- KIN27
- STK33
- CAMK1G
- NUAK1
- STK17B
- PRKD1
- PRKACG
- PAK4
- MKNK2
- PLK4
- PRKACB
- TSSK3
- PRKACA
- PAK2
- MAPK14
- DKFZp586A1021
- STK36
- SPEG
- RPS6KB1
- AKT2
- AURKC
- RPS6KA4
- MAPKAPK2
- PRKD3
- CDC2
- KALRN
- AKT1
- PIM2
- MARK4
- MAPK8
- PRKG2
- OBSCN
- TSSK6
- CDK1
- CAMKK1
Variants for CAMK2D Gene
| SNP ID | Clin | Chr 04 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs10000007 | -- | 113,632,097(+) | ATTAT(A/C)CAATC | intron-variant | |
| rs1000003392 | -- | 113,516,864(+) | GTAAA(A/T)CATAT | intron-variant | |
| rs1000004353 | -- | 113,495,374(+) | CAAGT(A/C)CTGAA | intron-variant | |
| rs1000008172 | -- | 113,588,702(+) | CCAGA(A/G)GTTTT | intron-variant | |
| rs1000020241 | -- | 113,492,145(+) | CTTCA(G/T)TTCTG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2677203 | CNV | deletion | 23128226 |
| esv3303071 | CNV | tandem duplication | 20981092 |
| esv3305937 | CNV | mobile element insertion | 20981092 |
| esv3340807 | CNV | insertion | 20981092 |
| esv3344069 | CNV | insertion | 20981092 |
| esv3564461 | CNV | deletion | 23714750 |
| esv3601813 | CNV | loss | 21293372 |
| esv3601816 | CNV | gain | 21293372 |
| esv3601817 | CNV | gain | 21293372 |
| nsv4474 | CNV | insertion | 18451855 |
| nsv4475 | CNV | deletion | 18451855 |
| nsv474651 | CNV | novel sequence insertion | 20440878 |
| nsv507189 | OTHER | sequence alteration | 20534489 |
| nsv525087 | CNV | gain | 19592680 |
| nsv595183 | CNV | loss | 21841781 |
| nsv830038 | CNV | gain | 17160897 |
| nsv950381 | CNV | duplication | 24416366 |
| nsv950382 | CNV | duplication | 24416366 |
Residual Variation Intolerance Score:
14.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.53;
44.10% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CAMK2D Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMK2D Gene
Disorders for CAMK2D Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| dilated cardiomyopathy |
|
|
| cardiomyopathy |
|
|
Search CAMK2D in MalaCards
View complete list of genes associated with diseases
Relevant External Links for CAMK2D
No data available for UniProtKB/Swiss-Prot and Genatlas for CAMK2D Gene
Publications for CAMK2D Gene
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation. (PMID: 20668654) Rellos P. … Knapp S. (PLoS Biol. 2010) 3 4 64
- A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G. … Riley B.P. (Hum. Mol. Genet. 2010) 3 46 64
- Cardiac ryanodine receptor phosphorylation by CaM Kinase II: keeping the balance right. (PMID: 19482609) Currie S. (Front. Biosci. 2009) 3 4 64
- A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease. (PMID: 19132087) Burgner D. … Hibberd M.L. (PLoS Genet. 2009) 3 46 64
Products for CAMK2D Gene
- R&D Systems Antibodies for CAMK2D (CaM Kinase II delta)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Browse Cell Selection and Detection Kits
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- Custom Antibody ServicesOriGene Antibodies for CAMK2D
- Browse OriGene ELISA Kits
- Custom Assay Services
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- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CAMK2D
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- OriGene qPCR primer pairs and template standards for CAMK2D
- OriGene qPCR primer pairs for CAMK2D
- OriGene CRISPR knockouts for CAMK2D
- OriGene ORF clones in human for CAMK2D
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for CAMK2D in any vector
- XM_005263251
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- XM_011532294
- XM_011532295
- XM_011532296
- NM_001221
- NM_172128
- NM_172127
- NM_172114
- NM_172115
- NM_172129
- GenScript Custom Purified and Recombinant Proteins Services for CAMK2D
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- GenScript: Design CRISPR guide RNA sequences for CAMK2D
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- Cell Signaling Technology (CST) Antibodies for CAMK2D (CAMK2D)
- Search for Antibodies & Assays
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for CAMK2D
- Novus Biologicals proteins and lysates for CAMK2D
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Taconic Biosciences Mouse Models for CAMK2D
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CAMK2D
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for CAMK2D
- Addgene plasmids for CAMK2D
- antibodies-online Antibodies for CAMK2D: See all 82
- antibodies-online Kits for CAMK2D: See all 6
- antibodies-online Proteins for CAMK2D: See all 14
- Search antibodies-online for peptides
- GeneTex CAMK2D antibody for CAMK2D
- Search GeneTex for Proteins for CAMK2D
- ViGene Biosciences adenoviral particle packaged cDNA for CAMK2D gene
- ViGene Biosciences lentiviral particle packaged cDNA for CAMK2D gene
- ViGene Biosciences ready-to-package AAV shRNAs for CAMK2D gene
- Search ViGene Biosciences for CAMK2D
- Santa Cruz Biotechnology (SCBT) Antibodies for CAMK2D
- Search Santa Cruz Biotechnology (SCBT) for CAMK2D siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CAMK2D
- Horizon Cell Lines for CAMK2D
- Cyagen custom Knockout/knockin (KOKI) mouse models for CAMK2D
- VectorBuilder custom plasmid, inducible vectors for CAMK2D
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CAMK2D
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CAMK2D Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer