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Aliases for CAMK2D Gene

Aliases for CAMK2D Gene

  • Calcium/Calmodulin-Dependent Protein Kinase II Delta 2 3
  • Calcium/Calmodulin-Dependent Protein Kinase (CaM Kinase) II Delta 2 3
  • CaM Kinase II Subunit Delta 3 4
  • CaMK-II Subunit Delta 3 4
  • EC 2.7.11.17 4 63
  • CAMKD 3 4
  • Calcium/Calmodulin-Dependent Protein Kinase Type II Subunit Delta 3
  • Calcium/Calmodulin-Dependent Protein Kinase Type II Delta Chain 3
  • CaM Kinase II Delta Subunit 3
  • CaM-Kinase II Delta Chain 3
  • CaMK-II Delta Subunit 3
  • EC 2.7.11 63

External Ids for CAMK2D Gene

Previous HGNC Symbols for CAMK2D Gene

  • CAMKD

Previous GeneCards Identifiers for CAMK2D Gene

  • GC04M114789
  • GC04M114655
  • GC04M114832
  • GC04M114731
  • GC04M114372
  • GC04M110100

Summaries for CAMK2D Gene

Entrez Gene Summary for CAMK2D Gene

  • The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.[provided by RefSeq, Nov 2008]

GeneCards Summary for CAMK2D Gene

CAMK2D (Calcium/Calmodulin-Dependent Protein Kinase II Delta) is a Protein Coding gene. Among its related pathways are Proteoglycans in cancer and ERK Signaling. GO annotations related to this gene include calmodulin binding and calmodulin-dependent protein kinase activity. An important paralog of this gene is DCX.

UniProtKB/Swiss-Prot for CAMK2D Gene

  • Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on Ser-2808. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor.

Tocris Summary for CAMK2D Gene

  • Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through autoinhibition. Increases in Ca2+ levels allows calmodulin to relieve this autoinhibition and activate the kinase activity. There are two main classes of CaMKs; mulitfunctional CaMKs (CaMKK, CaMKI, CaMKII and CaMKIV) which have multiple downstream targets and substrate-specific CaMKs (CaMKIII) which have only one known downstream target. All CaMKs, with the exception of CaMKII, exist as monomers and most are expressed ubiquitously. Some subtypes display specific distributions, for example, CaMKIVbeta is expressed exclusively in cerebellar granule cells. CaMKs have numerous cellular functions and they influence processes as diverse as gene transcription, cell survival, apoptosis, cytoskeletal re-organization and learning and memory.

Gene Wiki entry for CAMK2D Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMK2D Gene

Genomics for CAMK2D Gene

Regulatory Elements for CAMK2D Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CAMK2D Gene

Start:
113,451,032 bp from pter
End:
113,761,927 bp from pter
Size:
310,896 bases
Orientation:
Minus strand

Genomic View for CAMK2D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAMK2D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMK2D Gene

Proteins for CAMK2D Gene

  • Protein details for CAMK2D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13557-KCC2D_HUMAN
    Recommended name:
    Calcium/calmodulin-dependent protein kinase type II subunit delta
    Protein Accession:
    Q13557
    Secondary Accessions:
    • A8MVS8
    • Q52PK4
    • Q59G21
    • Q8N553
    • Q9UGH6
    • Q9UQE9

    Protein attributes for CAMK2D Gene

    Size:
    499 amino acids
    Molecular mass:
    56369 Da
    Quaternary structure:
    • CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other. Interacts with RRAD and CACNB2 (By similarity).
    Miscellaneous:
    • Expression of CAMK2D is significantly increased in patients suffering from dilated cardiomyopathy in PubMed:10189359
    SequenceCaution:
    • Sequence=BAD92525.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CAMK2D Gene

    Alternative splice isoforms for CAMK2D Gene

neXtProt entry for CAMK2D Gene

Proteomics data for CAMK2D Gene at MOPED

Post-translational modifications for CAMK2D Gene

  • Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.
  • Ubiquitination at Lys251
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for CAMK2D (CaM Kinase II delta)
  • Cell Signaling Technology (CST) Antibodies for CAMK2D (CAMK2D)

Domains for CAMK2D Gene

Suggested Antigen Peptide Sequences for CAMK2D Gene

Graphical View of Domain Structure for InterPro Entry

Q13557

UniProtKB/Swiss-Prot:

KCC2D_HUMAN :
  • Q13557
Domain:
  • The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
genes like me logo Genes that share domains with CAMK2D: view

Function for CAMK2D Gene

Molecular function for CAMK2D Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity.
UniProtKB/Swiss-Prot Function: Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on Ser-2808. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor.
UniProtKB/Swiss-Prot Induction: Activity is induced in skeletal muscle during exercise.

Enzyme Numbers (IUBMB) for CAMK2D Gene

Gene Ontology (GO) - Molecular Function for CAMK2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 22514276
GO:0004683 calmodulin-dependent protein kinase activity IDA 22514276
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 22514276
genes like me logo Genes that share ontologies with CAMK2D: view
genes like me logo Genes that share phenotypes with CAMK2D: view

Animal Models for CAMK2D Gene

MGI Knock Outs for CAMK2D:

Animal Model Products

CRISPR Products

miRNA for CAMK2D Gene

miRTarBase miRNAs that target CAMK2D

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAMK2D

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for CAMK2D Gene

Localization for CAMK2D Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMK2D Gene

Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAMK2D Gene COMPARTMENTS Subcellular localization image for CAMK2D gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
cytosol 4
nucleus 4

Gene Ontology (GO) - Cellular Components for CAMK2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS 12676814
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS 12676814
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with CAMK2D: view

Pathways for CAMK2D Gene

genes like me logo Genes that share pathways with CAMK2D: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CAMK2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IEA --
GO:0001558 regulation of cell growth NAS 9060999
GO:0001666 response to hypoxia IEA --
GO:0002026 regulation of the force of heart contraction TAS 23283722
GO:0003254 regulation of membrane depolarization IDA 22514276
genes like me logo Genes that share ontologies with CAMK2D: view

Compounds for CAMK2D Gene

(5) Tocris Compounds for CAMK2D Gene

Compound Action Cas Number
A 484954 CaM kinase III (eEF-2 kinase) inhibitor [142557-61-7]
Arcyriaflavin A Potent cdk4/cyclin D1 and CaM Kinase II inhibitor. Antiviral agent (anti-HCMV) [118458-54-1]
KN 93 CaM kinase II inhibitor; also K+ channel blocker (KV) [139298-40-1]
KN 93 phosphate CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278). [1188890-41-6]
STO-609 acetate Selective CaM kinase kinase inhibitor [1173022-21-3]

(3) HMDB Compounds for CAMK2D Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Calcium
  • Ca
7440-70-2

(1) Novoseek inferred chemical compound relationships for CAMK2D Gene

Compound -log(P) Hits PubMed IDs
calcium 27.7 2
genes like me logo Genes that share compounds with CAMK2D: view

Transcripts for CAMK2D Gene

Unigene Clusters for CAMK2D Gene

Calcium/calmodulin-dependent protein kinase II delta:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAMK2D

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAMK2D Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ·
SP1: - - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: -
SP6: -
SP7:

ExUns: 20c · 20d ^ 21
SP1:
SP2: - -
SP3:
SP4:
SP5: - -
SP6:
SP7:

Relevant External Links for CAMK2D Gene

GeneLoc Exon Structure for
CAMK2D
ECgene alternative splicing isoforms for
CAMK2D

Expression for CAMK2D Gene

mRNA expression in normal human tissues for CAMK2D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAMK2D Gene

SOURCE GeneReport for Unigene cluster for CAMK2D Gene Hs.144114

mRNA Expression by UniProt/SwissProt for CAMK2D Gene

Q13557-KCC2D_HUMAN
Tissue specificity: Expressed in cardiac muscle and skeletal muscle. Isoform Delta 3, isoform Delta 2, isoform Delta 8 and isoform Delta 9 are expressed in cardiac muscle. Isoform Delta 11 is expressed in skeletal muscle.
genes like me logo Genes that share expressions with CAMK2D: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CAMK2D Gene

Orthologs for CAMK2D Gene

This gene was present in the common ancestor of animals.

Orthologs for CAMK2D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAMK2D 35
  • 99.73 (n)
  • 100 (a)
CAMK2D 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CAMK2D 35
  • 95.17 (n)
  • 100 (a)
CAMK2D 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAMK2D 35
  • 94.86 (n)
  • 98.4 (a)
CAMK2D 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Camk2d 35
  • 91.45 (n)
  • 100 (a)
Camk2d 16
Camk2d 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CAMK2D 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAMK2D 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Camk2d 35
  • 92.45 (n)
  • 99 (a)
chicken
(Gallus gallus)
Aves CAMK2D 35
  • 87.77 (n)
  • 98.95 (a)
CAMK2D 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAMK2D 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.690 35
tropical clawed frog
(Silurana tropicalis)
Amphibia camk2d 35
  • 84.14 (n)
  • 96.84 (a)
zebrafish
(Danio rerio)
Actinopterygii camk2d1 35
  • 77.75 (n)
  • 92 (a)
camk2d2 36
  • 80 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000028 35
  • 65.75 (n)
  • 81.57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CaMKII 35
  • 70.39 (n)
  • 81.26 (a)
CaMKII 36
  • 73 (a)
OneToMany
CaMKII 37
  • 74 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-43 35
  • 65.53 (n)
  • 72.98 (a)
unc-43 36
  • 49 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8584 35
Species with no ortholog for CAMK2D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAMK2D Gene

ENSEMBL:
Gene Tree for CAMK2D (if available)
TreeFam:
Gene Tree for CAMK2D (if available)

Paralogs for CAMK2D Gene

genes like me logo Genes that share paralogs with CAMK2D: view

Variants for CAMK2D Gene

Sequence variations from dbSNP and Humsavar for CAMK2D Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs8175 -- 113,761,410(+) AATGG(A/G)AAAAC utr-variant-5-prime
rs9812 -- 113,451,324(+) GCAAA(A/T)CAAGA utr-variant-3-prime
rs9929 -- 113,453,977(+) TTTTG(C/T)CCACA utr-variant-3-prime
rs723091 -- 113,629,038(+) TAAAA(A/T)ATATA intron-variant
rs726661 -- 113,504,899(+) TATAG(G/T)GAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAMK2D Gene

Variant ID Type Subtype PubMed ID
nsv830038 CNV Gain 17160897
esv270214 CNV Insertion 20981092
esv260045 OTHER Complex 20981092
nsv4474 CNV Insertion 18451855
esv2677203 CNV Deletion 23128226
nsv4475 CNV Loss 18451855
nsv507189 CNV Insertion 20534489
nsv525087 CNV Gain 19592680

Relevant External Links for CAMK2D Gene

HapMap Linkage Disequilibrium report
CAMK2D
Human Gene Mutation Database (HGMD)
CAMK2D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMK2D Gene

Disorders for CAMK2D Gene

Relevant External Links for CAMK2D

Genetic Association Database (GAD)
CAMK2D
Human Genome Epidemiology (HuGE) Navigator
CAMK2D
genes like me logo Genes that share disorders with CAMK2D: view

No data available for UniProtKB/Swiss-Prot for CAMK2D Gene

Publications for CAMK2D Gene

  1. Cloning and quantitative determination of the human Ca2+/calmodulin- dependent protein kinase II (CaMK II) isoforms in human beta cells. (PMID: 10819240) Rochlitz H. … Pfeiffer A.F. (Diabetologia 2000) 3 4
  2. Identification of novel human tumor cell-specific CaMK-II variants. (PMID: 9060999) Tombes R.M. … Krystal G.W. (Biochim. Biophys. Acta 1997) 3 4
  3. Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium. (PMID: 10189359) Hoch B. … Karczewski P. (Circ. Res. 1999) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+- calmodulin-dependent protein kinase II. (PMID: 14722083) Gaertner T.R. … Waxham M.N. (J. Biol. Chem. 2004) 3 4

Products for CAMK2D Gene

Sources for CAMK2D Gene

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