Aliases for CAMK2B Gene
Aliases for CAMK2B Gene
External Ids for CAMK2B Gene
- HGNC: 1461
- Entrez Gene: 816
- Ensembl: ENSG00000058404
- OMIM: 607707
- UniProtKB: Q13554
Previous HGNC Symbols for CAMK2B Gene
- CAMKB
Previous GeneCards Identifiers for CAMK2B Gene
- GC07M043905
- GC07M043999
- GC07M044032
- GC07M044225
- GC07M044142
Summaries for CAMK2B Gene
-
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
GeneCards Summary for CAMK2B Gene
CAMK2B (Calcium/Calmodulin Dependent Protein Kinase II Beta) is a Protein Coding gene. Diseases associated with CAMK2B include Phencyclidine Abuse. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and Development Endothelin-1/EDNRA signaling. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is CAMK2G.
UniProtKB/Swiss-Prot for CAMK2B Gene
-
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.
-
Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through autoinhibition, which can be relieved by increases in Ca2+ levels.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMK2B Gene
Genomics for CAMK2B Gene
Regulatory Elements for CAMK2B Gene
Enhancers for CAMK2B Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH07G044307 | 1.3 | Ensembl ENCODE dbSUPER | 12.7 | +26.8 | 26803 | 1.3 | CTCF KLF1 TEAD4 KLF17 NFXL1 ZBTB40 RAD21 ZFHX2 ZBTB48 SMC3 | CAMK2B POLM AEBP1 NUDCD3 PIR57733 |
| GH07G044308 | 1.3 | Ensembl ENCODE dbSUPER | 12.3 | +24.9 | 24943 | 1.5 | CTCF TFAP4 SUZ12 RAD21 ZNF316 POLR2A EGR1 SMC3 PRDM10 MAFK | CAMK2B NUDCD3 NPC1L1 POLM PIR57733 |
| GH07G044286 | 0.9 | dbSUPER | 17.5 | +50.4 | 50404 | 7.1 | ATF1 CREB3L1 KLF17 RAD21 YY1 ZNF335 GLIS2 ZNF366 CREM EGR2 | CAMK2B POLM NPC1L1 AEBP1 PIR57733 |
| GH07G044472 | 1.2 | Ensembl ENCODE | 10.6 | -139.2 | -139240 | 2.3 | ELF3 TBP PKNOX1 FOXA2 ATF1 MLX ARID4B FEZF1 DMAP1 RAD21 | NUDCD3 RNU6-1097P CAMK2B AEBP1 STK17A GC07M044473 GC07M044472 |
| GH07G044288 | 1.1 | ENCODE dbSUPER | 11.3 | +44.1 | 44057 | 3.4 | HDAC1 ATF1 TBL1XR1 ZNF473 GATA2 SCRT2 SIRT6 FOS ZNF623 NR2F2 | CAMK2B POLM NPC1L1 AEBP1 COA1 PIR57733 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CAMK2B on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CAMK2B gene promoter:
Regulatory Element Products
Genomic Location for CAMK2B Gene
- Chromosome:
- 7
- Start:
- 44,217,150 bp from pter
- End:
- 44,334,577 bp from pter
- Size:
- 117,428 bases
- Orientation:
- Minus strand
Genomic View for CAMK2B Gene
Genes around CAMK2B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p13 by Ensembl
- 7p13 by Entrez Gene
- 7p13 by HGNC
CAMK2B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CAMK2B Gene
Proteins for CAMK2B Gene
-
Protein details for CAMK2B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13554-KCC2B_HUMAN
- Recommended name:
- Calcium/calmodulin-dependent protein kinase type II subunit beta
- Protein Accession:
- Q13554
- A4D2K0
- A4D2K1
- A4D2K2
- A4D2K3
- A4D2K4
- A4D2K5
- A4D2K6
- O95437
- O95438
- O95599
- Q9UGH7
- Q9UGH8
- Q9UGH9
- Q9UNX0
- Q9UNX7
- Q9UP00
- Q9Y5N4
- Q9Y6F4
Protein attributes for CAMK2B Gene
- Size:
- 666 amino acids
- Molecular mass:
- 72678 Da
- Quaternary structure:
-
- CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other (PubMed:14722083, Ref.19). Interacts with SYNGAP1 and CAMK2N2 (By similarity). Interacts with MPDZ (PubMed:15312654). Interacts with FOXO3 (By similarity).
- SequenceCaution:
-
- Sequence=AAC99802.1; Type=Frameshift; Positions=426, 433, 511, 516; Evidence={ECO:0000305};
Protein Expression for CAMK2B Gene
Selected DME Specific Peptides for CAMK2B Gene
- Q13554:
-
- WACGVILYILLVGYPPFWDEDQH
- TVASMMHRQETV
- NNGDFEAY
- CLKKFNARRKLKGAILTT
- KGAAVKLADFGLAIEV
- CTRFTDEYQL
- NIVRLHD
- YGKPVDIWA
- HYLVFDLVTGGELFEDIVARE
- GVILYIL
- FPSPEWD
- QAWFGFAGTPGYLSPEVL
- WACGVIL
- FEPEALGNLVEG
- VHRDLKPENLLLASK
- VKLADFG
- VTGGELF
- YSEADASHCIQQILE
- EPQTTVIHNP
- TEQLIEA
- MLTINPAKRI
- VVHRDLK
- QIKAGAYD
- TTIEDED
- KKADGVK
- PSPEWDTVTPEAKNLINQMLT
- LADFGLA
- QSEETRVWH
- DGKWQNVHFH
- DAACIAYIRLTQY
- DFHRFYFEN
- RKQEIIK
- LKPENLL
- RDLKPEN
- GKGAFSVVRRC
- AAKIINTKKL
- TCTRFTD
- FNARRKL
- NIVRLHDSISEEG
- QKLEREARICR
- VHRDLKP
Post-translational modifications for CAMK2B Gene
- Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for CAMK2B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- NP_001211.3
- NP_001280099.1
- NP_742075.1
- NP_742076.1
- NP_742077.1
- NP_742078.1
- NP_742079.1
- NP_742080.1
- NP_742081.1
- XP_005249919.1
- XP_005249921.1
- XP_006715844.1
- XP_006715847.1
- XP_011513849.1
- XP_011513851.1
- XP_011513852.1
- XP_011513853.1
- XP_011513854.1
- XP_011513855.1
- XP_011513856.1
- XP_011513857.1
- XP_011513858.1
- XP_011513859.1
- XP_011513860.1
- XP_011513861.1
- XP_016868149.1
- XP_016868150.1
- XP_016868151.1
- XP_016868152.1
- XP_016868153.1
- XP_016868154.1
- XP_016868155.1
- XP_016868156.1
- XP_016868157.1
- XP_016868158.1
- XP_016868159.1
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CAMK2B
- Cell Signaling Technology (CST) Antibodies for CAMK2B (CAMK2B)
- Novus Biologicals Antibodies for CAMK2B
-
Cloud-Clone Corp. Antibodies for CAMK2B
- Invitrogen Antibodies for CAMK2B
- antibodies-online Antibodies for CAMK2B: See all 124
- GeneTex CAMK2B antibody for CAMK2B
-
Santa Cruz Biotechnology (SCBT) Antibodies for CAMK2B
Protein Products
- EMD Millipore Purified and/or Recombinant CAMK2B Protein
- Search Origene for MassSpec and Protein Over-expression Lysates for CAMK2B
- Origene Custom Protein Services for CAMK2B
- Sino Biological Recombinant Proteins for CAMK2B
- Sino Biological Cell Lysates for CAMK2B
-
Cloud-Clone Corp. Proteins for CAMK2B
- antibodies-online Proteins for CAMK2B: See all 13
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CAMK2B
-
ProSci Proteins for CAMK2B
Domains & Families for CAMK2B Gene
Gene Families for CAMK2B Gene
Protein Domains for CAMK2B Gene
Suggested Antigen Peptide Sequences for CAMK2B Gene
- GenScript: Design optimal peptide antigens:
-
- Calcium/calmodulin-dependent protein kinase (CaM kinase) II beta (A4D2J9_HUMAN)
- Calcium/calmodulin-dependent protein kinase (CaM kinase) II beta (A4D2K5_HUMAN)
- cDNA FLJ58056, highly similar to Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (B7Z1Z6_HUMAN)
- Calcium/calmodulin-dependent protein kinase (CaM kinase) II beta, isoform CRA_d (D3DVK8_HUMAN)
- Calcium/calmodulin-dependent protein kinase type II subunit beta (KCC2B_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q13554UniProtKB/Swiss-Prot:
KCC2B_HUMAN :- The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.
- Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
- Domain:
-
- The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization.
- Family:
-
- Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Function for CAMK2B Gene
Molecular function for CAMK2B Gene
- GENATLAS Biochemistry:
- protein kinase,type II,calcium/calmodulin dependent,beta isoform
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a protein = ADP + a phosphoprotein.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity.
- UniProtKB/Swiss-Prot Function:
- Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.
- UniProtKB/Swiss-Prot Induction:
- Activity is induced in skeletal muscle during exercise.
Enzyme Numbers (IUBMB) for CAMK2B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003779 | actin binding | IEA | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | TAS | -- |
| GO:0004683 | calmodulin-dependent protein kinase activity | IBA | -- |
Phenotypes for CAMK2B Gene
- MGI mutant phenotypes for CAMK2B:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for CAMK2B:
-
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Increased transferrin (TF) endocytosis
- Decreased viability
- Decreased cell migration
- Synthetic lethal with imatinib mesylate
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Apoptosis resistance
- Decreased Cdk9 T-loop phosphorylation
Animal Model Products
-
Taconic Biosciences Mouse Models for CAMK2B
- Cyagen custom Knockout/knockin (KOKI) mouse models for CAMK2B
-
- Search ViGene Biosciences for CAMK2B
CRISPR Products
-
OriGene CRISPR knockouts for CAMK2B
-
Santa Cruz Biotechnology (SCBT) CRISPR for CAMK2B
- GenScript: Design CRISPR guide RNA sequences for CAMK2B
miRNA for CAMK2B Gene
- miRTarBase miRNAs that target CAMK2B
miRNA Products
- Search ViGene Biosciences for CAMK2B
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CAMK2B
- Browse OriGene Inhibitory RNA Products For CAMK2B
Clone Products
-
OriGene ORF clones in human for CAMK2B
- RC215639
- RC215639L1
- RC215639L2
- RG215639
- RC238812
- RC218145
- RC218145L1
- RC218145L2
- RG218145
- RC218194
- RC218194L1
- RC218194L2
- RG218194
- RC219723
- RC219723L1
- RC219723L2
- RG219723
- RC205669
- RC205669L1
- RC205669L2
- RG205669
- RC218315
- RC218315L1
- RC218315L2
- RG218315
- RC216552
- RC216552L1
- RC216552L2
- RG216552
- RC218366
- RC218366L1
- RC218366L2
- RG218366
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
-
GenScript: Next-day shipping cDNA ORF clone for CAMK2B in any vector
- XM_011515549
- XM_011515548
- XM_011515547
- XM_006715784
- XM_006715781
- XM_005249864
- XM_005249862
- NM_172084
- NM_172083
- NM_172082
- NM_172081
- NM_172080
- NM_172079
- NM_172078
- NM_001220
- NM_001293170
- XM_011515550
- XM_011515551
- XM_011515552
- XM_011515553
- XM_011515554
- XM_011515555
- XM_011515556
- XM_011515557
- XM_011515558
- XM_011515559
- XM_011515560
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CAMK2B
- VectorBuilder custom plasmid, inducible vectors for CAMK2B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CAMK2B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CAMK2B
Flow Cytometry Products
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAMK2B Gene
Localization for CAMK2B Gene
Subcellular locations from UniProtKB/Swiss-Prot for CAMK2B Gene
- Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=In slow-twitch muscle, evenly distributed between longitudinal SR and junctional SR.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 3 |
| endoplasmic reticulum | 3 |
| extracellular | 1 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA,IBA | -- |
| GO:0005815 | microtubule organizing center | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
Pathways & Interactions for CAMK2B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Post NMDA receptor activation events | ||
| 3 | Development Angiotensin activation of ERK | ||
| 4 | Development Endothelin-1/EDNRA signaling | ||
| 5 | Cardiac conduction |
.39
|
|
Pathways by source for CAMK2B Gene
4 Sino Biological pathways for CAMK2B Gene
1 GeneTex pathway for CAMK2B Gene
2 Cell Signaling Technology pathways for CAMK2B Gene
5 BioSystems pathways for CAMK2B Gene
69 Reactome pathways for CAMK2B Gene
1 PharmGKB pathway for CAMK2B Gene
26 KEGG pathways for CAMK2B Gene
18 GeneGo (Thomson Reuters) pathways for CAMK2B Gene
1 R&D Systems pathway for CAMK2B Gene
18 Qiagen pathways for CAMK2B Gene
Interacting Proteins for CAMK2B Gene
Selected Interacting proteins:
ENSP00000379098
Q13554-KCC2B_HUMAN
for CAMK2B Gene via
STRING
IID
UniProtKB
SIGNOR curated interactions for CAMK2B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0006468 | protein phosphorylation | TAS | 9060999 |
| GO:0007165 | signal transduction | TAS | 9060999 |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007399 | nervous system development | IEA | -- |
Drugs & Compounds for CAMK2B Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Adenosine triphosphate | Approved | Nutra | 0 | |||
| [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrile | Experimental | Pharma | Target | 0 | ||
| KN-93 Phosphate | Pharma | CaM kinase II inhibitor, water soluble and cell permeable, CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278). | 0 | |||
| Autocamtide-2-related inhibitory peptide | Pharma | inhibitor of calmodulin-dependent protein kinase II (CaM-kinase II, CaMKII) | 0 | |||
| CaMKII-IN-1 | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
||
| Autocamtide-2-related inhibitory peptide, myristoylated |
|
201422-04-0 |
|
|
||
| KN 93 |
|
139298-40-1 |
|
|
(5) Tocris Compounds for CAMK2B Gene
| Compound | Action | Cas Number |
|---|---|---|
| A 484954 | CaM kinase III (eEF-2 kinase) inhibitor | 142557-61-7 |
| Autocamtide-2-related inhibitory peptide, myristoylated | CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptide | 201422-04-0 |
| KN 93 | CaM kinase II inhibitor; also K+ channel blocker (KV) | 139298-40-1 |
| KN 93 phosphate | CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278). | 1188890-41-6 |
| STO-609 acetate | Selective CaM kinase kinase inhibitor | 1173022-21-3 |
(5) ApexBio Compounds for CAMK2B Gene
| Compound | Action | Cas Number |
|---|---|---|
| Autocamtide-2-related inhibitory peptide | inhibitor of calmodulin-dependent protein kinase II (CaM-kinase II, CaMKII) | 167114-91-2 |
| CaMKII-IN-1 | 1208123-85-6 | |
| KN-92 | CaMKII inhibitor | 176708-42-2 |
| KN-93 hydrochloride | CaMK II inhibitor | |
| KN-93 Phosphate | CaM kinase II inhibitor, water soluble and cell permeable | 1188890-41-6 |
Drug Products
- ApexBio compounds for CAMK2B
Transcripts for CAMK2B Gene
mRNA/cDNA for CAMK2B Gene
- (36) REFSEQ mRNAs :
- (18) Additional mRNA sequences :
- (285) Selected AceView cDNA sequences:
- (26) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CAMK2B Gene
CRISPR Products
-
OriGene CRISPR knockouts for CAMK2B
-
Santa Cruz Biotechnology (SCBT) CRISPR for CAMK2B
- GenScript: Design CRISPR guide RNA sequences for CAMK2B
miRNA Products
- Search ViGene Biosciences for CAMK2B
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CAMK2B
- Browse OriGene Inhibitory RNA Products For CAMK2B
Clone Products
-
OriGene ORF clones in human for CAMK2B
- RC215639
- RC215639L1
- RC215639L2
- RG215639
- RC238812
- RC218145
- RC218145L1
- RC218145L2
- RG218145
- RC218194
- RC218194L1
- RC218194L2
- RG218194
- RC219723
- RC219723L1
- RC219723L2
- RG219723
- RC205669
- RC205669L1
- RC205669L2
- RG205669
- RC218315
- RC218315L1
- RC218315L2
- RG218315
- RC216552
- RC216552L1
- RC216552L2
- RG216552
- RC218366
- RC218366L1
- RC218366L2
- RG218366
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
-
GenScript: Next-day shipping cDNA ORF clone for CAMK2B in any vector
- XM_011515549
- XM_011515548
- XM_011515547
- XM_006715784
- XM_006715781
- XM_005249864
- XM_005249862
- NM_172084
- NM_172083
- NM_172082
- NM_172081
- NM_172080
- NM_172079
- NM_172078
- NM_001220
- NM_001293170
- XM_011515550
- XM_011515551
- XM_011515552
- XM_011515553
- XM_011515554
- XM_011515555
- XM_011515556
- XM_011515557
- XM_011515558
- XM_011515559
- XM_011515560
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for CAMK2B
- VectorBuilder custom plasmid, inducible vectors for CAMK2B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CAMK2B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c | · | 14d | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: |
| ExUns: | 24 | ^ | 25 | ^ | 26a | · | 26b | ^ | 27 | ^ | 28 | ^ | 29a | · | 29b | ^ | 30 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||
| SP2: | - | - | |||||||||||||||
| SP3: | - | - | |||||||||||||||
| SP4: | - | - | |||||||||||||||
| SP5: | - | - | |||||||||||||||
| SP6: | - | - | - | ||||||||||||||
| SP7: | |||||||||||||||||
| SP8: | |||||||||||||||||
| SP9: | |||||||||||||||||
| SP10: | |||||||||||||||||
| SP11: | |||||||||||||||||
| SP12: | |||||||||||||||||
| SP13: | - | - | - | - | |||||||||||||
| SP14: | - | ||||||||||||||||
| SP15: |
Expression for CAMK2B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Adult Endothelial Cells Blood Brain Barrier
- Hippocampus
- Thalamus
- Cerebellum
- Amygdala
- Gut Tube (Gastrointestinal Tract)
-
Peripheral Nervous System (Nervous System)
- Schwann Precursor Cells Peripheral Nerve Domain
-
Endothelium (Cardiovascular System)
- Adult Endothelial Cells Blood Brain Barrier
- Eye (Sensory Organs)
- Adipose (Muscoskeletal System)
- Neurons (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for CAMK2B Gene
This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.6), Brain - Cerebellum (x5.5), Brain - Putamen (basal ganglia) (x4.8), and Brain - Nucleus accumbens (basal ganglia) (x4.0).
This gene is overexpressed in Brain (40.1) and Frontal cortex (19.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CAMK2B Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CAMK2B Gene:
CAMK2BSOURCE GeneReport for Unigene cluster for CAMK2B Gene:
Hs.351887mRNA Expression by UniProt/SwissProt for CAMK2B Gene:
Q13554-KCC2B_HUMAN
Tissue specificity:
Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle.
Evidence on tissue expression from TISSUES for CAMK2B Gene
- Nervous system(4.3)
- Liver(4)
- Lung(4)
- Muscle(4)
Primer Products
-
OriGene qPCR primer pairs and template standards for CAMK2B
-
OriGene qPCR primer pairs for CAMK2B
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CAMK2B Gene
Orthologs for CAMK2B Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| oppossum (Monodelphis domestica) |
Mammalia | CAMK2B 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Camk2b 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Camk2b 34 16 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CAMK2B 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CAMK2B 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CAMK2B 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CAMK2B 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CAMK2B 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | camk2b 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.987 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | camk2b2 35 |
|
OneToMany | |
| camk2b1 35 |
|
OneToMany | |||
| LOC798222 34 |
|
||||
| Dr.12561 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CaMKII 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | unc-43 35 |
|
OneToMany | |
| corn (Zea mays) |
Liliopsida | Zm.1824 34 |
|
- Species where no ortholog for CAMK2B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CAMK2B Gene
Paralogs for CAMK2B Gene
(73) SIMAP similar genes for CAMK2B Gene using alignment to 13 proteins:
- CAMK2D
- CAMK2A
- CAMK2G
- CASK
- DAPK3
- Par1b
- KIAA0999
- BRSK1
- CDK4
- SIK3
- SNRK
- MKNK1
- MARK1
- DAPK1
- MARK2
- STK11
- RPS6KA6
- MYLK
- CAMK1D
- PSKH1
- BRSK2
- PNCK
- RPS6KA3
- PHKG2
- HUNK
- SIK1
- MYLK3
- CAMK1
- PRKAA1
- RPS6KA1
- RPS6KA4
- PRKD1
- RPS6KA5
- MGC45428
- RPS6KA2
- DKFZp564L2416
- DAPK2
- TRIB1
- MYLK4
- PRKD2
- PHKG1
- PLK4
- PRKY
- STK17A
- TTN
- MARK3
- CHEK1
- TRIB2
- KIN27
- KALRN
- DCLK3
- PSKH2
- NUAK1
- CAMK1G
- CAMKV
- MKNK2
- CHEK2
- PRKACB
- STK17B
- PRKACG
- SPEG
- PRKAA2
- AURKC
- MAPKAPK3
- CAMK4
- PAK4
- TSSK3
- PIM2
- MARK4
- DKFZp586A1021
- STK33
- MAPK8
- CDC2
Variants for CAMK2B Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs555460132 | A colorectal adenocarcinoma sample | 44,228,798(+) | TACAC(A/G)GGGAG | intron-variant, reference, missense | |
| rs1000005743 | -- | 44,325,623(+) | CGCGC(C/T)GCACA | intron-variant, upstream-variant-2KB, utr-variant-5-prime | |
| rs1000050549 | -- | 44,246,436(+) | ATGCC(-/CACA)CAGAC | intron-variant | |
| rs1000097920 | -- | 44,219,208(+) | ACACA(C/T)GTGGA | intron-variant, downstream-variant-500B, utr-variant-3-prime | |
| rs1000100361 | -- | 44,272,760(+) | CCAGG(C/G)TACAC | intron-variant |
Residual Variation Intolerance Score:
19.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.79;
79.05% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CAMK2B Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMK2B Gene
Disorders for CAMK2B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| phencyclidine abuse |
|
|
Search CAMK2B in MalaCards
View complete list of genes associated with diseases
Relevant External Links for CAMK2B
No data available for UniProtKB/Swiss-Prot and Genatlas for CAMK2B Gene
Publications for CAMK2B Gene
- Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. (PMID: 22399527) Kristiansson K. … Salomaa V. (Circ Cardiovasc Genet 2012) 3 46 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- A common variant in DRD3 receptor is associated with autism spectrum disorder. (PMID: 19058789) de Krom M. … van Ree J.M. (Biol. Psychiatry 2009) 3 46 64
- Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PMID: 19156168) Need A.C. … Goldstein D.B. (Eur. J. Hum. Genet. 2009) 3 46 64
- Calmodulin-kinases: modulators of neuronal development and plasticity. (PMID: 18817731) Wayman G.A. … Soderling T.R. (Neuron 2008) 3 4 64
Products for CAMK2B Gene
- Browse Small Molecules at EMD Millipore
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CAMK2B
- EMD Millipore Purified and/or Recombinant CAMK2B Protein
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- OriGene CRISPR knockouts for CAMK2B
- OriGene ORF clones in human for CAMK2B
- RC215639
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- RC218366L1
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- RG218366
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- NM_001220
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- GenScript Custom Purified and Recombinant Proteins Services for CAMK2B
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- Sino Biological Antibodies
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- Novus Biologicals
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- Taconic Biosciences Mouse Models for CAMK2B
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CAMK2B
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for CAMK2B
- Addgene plasmids for CAMK2B
- antibodies-online Antibodies for CAMK2B: See all 124
- antibodies-online Kits for CAMK2B: See all 11
- antibodies-online Proteins for CAMK2B: See all 13
- Search antibodies-online for peptides
- GeneTex CAMK2B antibody for CAMK2B
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- Santa Cruz Biotechnology (SCBT) Antibodies for CAMK2B
- Search Santa Cruz Biotechnology (SCBT) for CAMK2B siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CAMK2B
- Horizon Cell Lines for CAMK2B
- Cyagen custom Knockout/knockin (KOKI) mouse models for CAMK2B
- VectorBuilder custom plasmid, inducible vectors for CAMK2B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CAMK2B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CAMK2B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
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- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer