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CAMK2B Gene

protein-coding   GIFtS: 71
GCID: GC07M044225

Calcium/Calmodulin-Dependent Protein Kinase II Beta

(Previous name: calcium/calmodulin-dependent protein kinase (CaM kinase)...)
(Previous symbol: CAMKB)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calcium/Calmodulin-Dependent Protein Kinase II Beta1 2     CAMK22 3
CAMKB1 2 3     EC 2.7.11.173 8
CaM Kinase II Beta Subunit1 2     Calcium/Calmodulin-Dependent Protein Kinase (CaM Kinase) II Beta1
CaM-Kinase II Beta Chain1 2     Calcium/Calmodulin-Dependent Protein Kinase Type II Beta Chain1
Proline Rich Calmodulin-Dependent Protein Kinase1 2     Calcium/Calmodulin-Dependent Protein Kinase Type II Subunit Beta2
CaMK-II Subunit Beta2 3     CaM Kinase II Subunit Beta3
CAM22 3     EC 2.7.118

External Ids:    HGNC: 14611   Entrez Gene: 8162   Ensembl: ENSG000000584047   OMIM: 6077075   UniProtKB: Q135543   

Export aliases for CAMK2B gene to outside databases

Previous GC identifers: GC07M043905 GC07M043999 GC07M044032 GC07M044142


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CAMK2B Gene:
The product of this gene belongs to the serine/threonine protein kinase family and to the
Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of
plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha,
beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this
chain have different cellular localizations and interact differently with calmodulin. Eight transcript variants
encoding eight distinct isoforms have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CAMK2B Gene:
CAMK2B (calcium/calmodulin-dependent protein kinase II beta) is a protein-coding gene. Diseases associated with CAMK2B include phencyclidine abuse, and drug addiction. GO annotations related to this gene include actin binding and calmodulin-dependent protein kinase activity. An important paralog of this gene is PNCK.

UniProtKB/Swiss-Prot: KCC2B_HUMAN, Q13554
Function: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding
and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and
regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential
structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin
filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A,
which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity
which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons,
promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in
the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in
regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control
of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and
phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2

summary for CAMK2B Gene:
Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second
messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through
autoinhibition. Increases in Ca2+ levels allows calmodulin to relieve this autoinhibition and activate the
kinase activity. There are two main classes of CaMKs; mulitfunctional CaMKs (CaMKK, CaMKI, CaMKII and
CaMKIV) which have multiple downstream targets and substrate-specific CaMKs (CaMKIII) which have only one
known downstream target. All CaMKs, with the exception of CaMKII, exist as monomers and most are expressed
ubiquitously. Some subtypes display specific distributions, for example, CaMKIVbeta is expressed exclusively
in cerebellar granule cells. CaMKs have numerous cellular functions and they influence processes as diverse
as gene transcription, cell survival, apoptosis, cytoskeletal re-organization and learning and memory.

Gene Wiki entry for CAMK2B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CAMK2B gene promoter:
         Max1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CAMK2B promoter sequence
   Search Chromatin IP Primers for CAMK2B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CAMK2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14.3-p14.1   Ensembl cytogenetic band:  7p13   HGNC cytogenetic band: 7p14.3-p14.1

CAMK2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAMK2B gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M044225:  view genomic region     (about GC identifiers)

Start:
44,256,749 bp from pter      End:
44,374,176 bp from pter
Size:
117,428 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 44,296,255-44,404,749     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KCC2B_HUMAN, Q13554 (See protein sequence)
Recommended Name: Calcium/calmodulin-dependent protein kinase type II subunit beta  
Size: 666 amino acids; 72678 Da
Subunit: CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta
(CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with
two hexameric rings stacked one on top of the other. Interacts with SYNGAP1 and CAMK2N2 (By similarity).
Interacts with MPDZ
Sequence caution: Sequence=AAC99802.1; Type=Frameshift; Positions=426, 433, 511, 516;
1 PDB 3D structure from and Proteopedia for CAMK2B:
3BHH (3D)    
Secondary accessions: A4D2K0 A4D2K1 A4D2K2 A4D2K3 A4D2K4 A4D2K5 A4D2K6 O95437 O95438 O95599
Q9UGH7 Q9UGH8 Q9UGH9 Q9UNX0 Q9UNX7 Q9UP00 Q9Y5N4 Q9Y6F4
Alternative splicing: 8 isoforms:  Q13554-1   Q13554-2   Q13554-3   Q13554-4   Q13554-5   Q13554-6   Q13554-7   Q13554-8   
(Ref.1 (AAD42036) sequence is in conflict in position: 316:A->V)

Explore the universe of human proteins at neXtProt for CAMK2B: NX_Q13554

Explore proteomics data for CAMK2B at MOPED

Post-translational modifications: 

  • Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the
    kinase into an activated state1
  • Ubiquitination2 at Lys259
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CAMK2B (Q13554) (see all 41)
     TEQLIEA  VVHRDLK  TTIEDED  KKADGVK 


    See CAMK2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (8 alternative transcripts): 
    NP_001211.3  NP_742075.1  NP_742076.1  NP_742077.1  NP_742078.1  NP_742079.1  NP_742080.1  NP_742081.1  

    ENSEMBL proteins: 
     ENSP00000326375   ENSP00000379098   ENSP00000428912   ENSP00000410445   ENSP00000397937  
     ENSP00000351542   ENSP00000326427   ENSP00000326600   ENSP00000326544   ENSP00000326518  
     ENSP00000258682   ENSP00000379096   ENSP00000388951   ENSP00000390419   ENSP00000400387  
     ENSP00000388445   ENSP00000390292   ENSP00000422416  
    Reactome Protein details: Q13554

    CAMK2B Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CAMK2B Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CAMK2B
    OriGene Protein Over-expression Lysate for CAMK2B
    OriGene MassSpec for CAMK2B
    OriGene Custom Protein Services for CAMK2B
    GenScript Custom Purified and Recombinant Proteins Services for CAMK2B
    Novus Biologicals CAMK2B Proteins
    Novus Biologicals CAMK2B Lysates
    Sino Biological Recombinant Protein for CAMK2B
    Sino Biological Cell Lysate for CAMK2B
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    CAMK2B Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CAMK2B
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CAMK2B 
    OriGene Antibodies for CAMK2B
    OriGene Custom Antibody Services for CAMK2B
    Novus Biologicals CAMK2B Antibodies
    Abcam antibodies for CAMK2B (Q13555, Q9UQM7, Q13557, Q13554)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for CAMK2B
    LSBio Antibodies in human, mouse, rat for CAMK2B

    CAMK2B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CAMK2B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CAMK2B
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: calcium/calmodulin-dependent protein kinase II beta subunit
    CAMK2 family
    Selected non-AGC protein kinase activities

    Selected InterPro protein domains (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q13554

    ProtoNet protein and cluster: Q13554

    1 Blocks protein domain: IPB013543 Calcium/calmodulin dependent protein kinase II

    UniProtKB/Swiss-Prot: KCC2B_HUMAN, Q13554
    Domain: The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for
    oligomerization
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily
    Similarity: Contains 1 protein kinase domain


    CAMK2B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCC2B_HUMAN, Q13554
    Function: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding
    and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and
    regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential
    structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin
    filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A,
    which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity
    which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons,
    promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in
    the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in
    regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control
    of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and
    phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that
    relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a
    constitutively active form and confers to the kinase a Ca(2+)-independent activity
    Induction: Activity is induced in skeletal muscle during exercise

         Genatlas biochemistry entry for CAMK2B:
    protein kinase,type II,calcium/calmodulin dependent,beta isoform

         Enzyme Numbers (IUBMB): EC 2.7.11.171 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004683calmodulin-dependent protein kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
         
    CAMK2B for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CAMK2B:
     Gemcitabine induced cell-death  Increased apoptosis  Synthetic lethal with imatinib  Weaker migration 

         2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Camk2b):
     behavior/neurological  nervous system 

    CAMK2B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Camk2btm1Yelg for CAMK2B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CAMK2B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CAMK2B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAMK2B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAMK2B

    miRNA
    Products:
        
    miRTarBase miRNAs that target CAMK2B:
    hsa-mir-186-5p (MIRT045124)

    Block miRNA regulation of human, mouse, rat CAMK2B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CAMK2B (see all 38):
    hsa-miR-605 hsa-miR-765 hsa-let-7a-2* hsa-miR-624 hsa-miR-3138 hsa-miR-500a hsa-miR-1184 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidCAMK2B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CAMK2B
    Predesigned siRNA for gene silencing in human, mouse, rat CAMK2B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CAMK2B

    Clone
    Products:
         
    OriGene clones in human, mouse for CAMK2B (see all 48)
    OriGene ORF clones in mouse, rat for CAMK2B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 8): CAMK2B (NM_172081)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAMK2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMK2B

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CAMK2B
    Browse ESI BIO Cell Lines and PureStem Progenitors for CAMK2B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMK2B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KCC2B_HUMAN, Q13554: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
    (By similarity). Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=In
    slow-twitch muscle, evenly distributed between longitudinal SR and junctional SR
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    endoplasmic reticulum5
    cytosol4
    nucleus4
    plasma membrane4
    extracellular1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005815microtubule organizing center IEA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0030666endocytic vesicle membrane TAS--

    CAMK2B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CAMK2B About   (see all 52)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathways0.40
    2Post NMDA receptor activation events
    Post NMDA receptor activation events0.90
    Ras activation uopn Ca2+ infux through NMDA receptor0.00
    Activation of NMDA receptor upon glutamate binding and postsynaptic events0.90
    Unblocking of NMDA receptor, glutamate binding and activation0.00
    CREB phosphorylation through the activation of Ras0.78
    CREB phosphorylation through the activation of CaMKII0.00
    Long-term potentiation0.35
    3Development Endothelin 1 EDNRA signaling
    Development Endothelin 1 EDNRA signaling0.41
    GnRH signaling pathway0.38
    Development Endothelin 1 EDNRA transactivation of EGFR0.41
    Inflammatory mediator regulation of TRP channels0.37
    Cytoskeleton remodeling FAK signaling0.41
    4ErbB signaling pathway
    ErbB signaling pathway0.52
    EGFR Inhibitor Pathway, Pharmacodynamics0.49
    5Immune response IFN gamma signaling pathway
    IFN-gamma pathway0.43
    Immune response IFN gamma signaling pathway0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CAMK2B
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CAMK2B (see all 18)
        Molecular Mechanisms of Cancer
    PI3K Signaling in B-Lymphocyte
    Melatonin Signaling
    IP3 Pathway
    CREB Pathway

    2 Cell Signaling Technology (CST) Pathways for CAMK2B
        Ca, cAMP and Lipid Signaling
    Neuroscience

    Selected GeneGo (Thomson Reuters) Pathways for CAMK2B (see all 18)
        Development Endothelin-1/EDNRA transactivation of EGFR
    Signal transduction cAMP signaling
    Development Endothelin-1/EDNRA signaling
    Development Angiotensin signaling via PYK2
    Development Activation of ERK by Alpha-1 adrenergic receptors

    Selected BioSystems Pathways for CAMK2B (see all 7)
        Myometrial Relaxation and Contraction Pathways
    Hypothetical Network for Drug Addiction
    Calcium Regulation in the Cardiac Cell
    TGF-beta Receptor Signaling Pathway
    Wnt Signaling Pathway NetPath

    2 Sino Biological Pathways for CAMK2B
        EGFR Signaling Pathway
    Non-Canonical Wnt Pathway

    Selected Reactome Pathways for CAMK2B (see all 7)
        Ras activation uopn Ca2+ infux through NMDA receptor
    Unblocking of NMDA receptor, glutamate binding and activation
    Interferon gamma signaling
    Trafficking of AMPA receptors
    CREB phosphorylation through the activation of CaMKII

    1 PharmGKB Pathway for CAMK2B
        EGFR Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for CAMK2B) (see all 22):
        ErbB signaling pathway
    Calcium signaling pathway
    HIF-1 signaling pathway
    Oocyte meiosis
    Adrenergic signaling in cardiomyocytes


    CAMK2B for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CAMK2B: 
              Circadian Rhythms in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CAMK2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CAMK2B (Q135543 ENSP000002586824) via UniProtKB, MINT, STRING, and/or I2D (see all 109)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK1P284823, ENSP000002158324I2D: score=5 STRING: ENSP00000215832
    ACTN4O437073, ENSP000002526994I2D: score=4 STRING: ENSP00000252699
    CAMK2AQ9UQM73, ENSP000003814124I2D: score=2 STRING: ENSP00000381412
    GAPDHP044063, ENSP000002292394I2D: score=2 STRING: ENSP00000229239
    CAMK2DQ135573, ENSP000003397404I2D: score=1 STRING: ENSP00000339740
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IEA--
    GO:0002030inhibitory G-protein coupled receptor phosphorylation IEA--
    GO:0006468protein phosphorylation TAS9060999
    GO:0006816calcium ion transport IEA--
    GO:0007165signal transduction TAS9060999

    CAMK2B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for CAMK2B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    NH 125CaM kinase III (eEF-2 kinase) inhibitor[278603-08-0]
    STO-609 acetateSelective CaM kinase kinase inhibitor[52029-86-4]
    A 484954CaM kinase III (eEF-2 kinase) inhibitor[142557-61-7]
    KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
    Arcyriaflavin APotent cdk4/cyclin D1 and CaM Kinase II inhibitor. Antiviral agent (anti-HCMV)[118458-54-1]

    3 HMDB Compounds for CAMK2B    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for CAMK2B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrile-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CAMK2B gene (8 alternative transcripts): 
    NM_001220.4  NM_172078.2  NM_172079.2  NM_172080.2  NM_172081.2  NM_172082.2  NM_172083.2  NM_172084.2  

    Unigene Cluster for CAMK2B:

    Calcium/calmodulin-dependent protein kinase II beta
    Hs.351887  [show with all ESTs]
    Unigene Representative Sequence: NM_001220
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000350811 ENST00000395749(uc003tkn.2 uc003tkq.2) ENST00000523845
    ENST00000425809 ENST00000440254 ENST00000358707 ENST00000466584 ENST00000353625
    ENST00000497584 ENST00000489429 ENST00000353185 ENST00000347193 ENST00000346990
    ENST00000258682 ENST00000395747 ENST00000433930 ENST00000497127 ENST00000495819

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CAMK2B (see all 38):
    hsa-miR-605 hsa-miR-765 hsa-let-7a-2* hsa-miR-624 hsa-miR-3138 hsa-miR-500a hsa-miR-1184 hsa-miR-186
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    GenScript: all cDNA clones in your preferred vector (see all 8): CAMK2B (NM_172081)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMK2B
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      QuantiTect SYBR Green Assays in human, mouse, rat CAMK2B
      QuantiFast Probe-based Assays in human, mouse, rat CAMK2B

    Additional mRNA sequence: 

    AB073352.1 AF078803.1 AF081572.1 AF081924.1 AF083419.1 AF112471.1 AF112472.1 AF131776.1 
    AF140350.1 AJ252236.1 AJ252238.1 AK222703.1 AK290148.1 AK294138.1 AK315663.1 BC019070.2 
    U23460.1 U50358.1 

    18 DOTS entries:

    DT.316421  DT.91759503  DT.91759506  DT.91759502  DT.95235488  DT.95235504  DT.91745066  DT.100792398 
    DT.95235493  DT.100792392  DT.100027419  DT.121113697  DT.100771532  DT.40238953  DT.95235487  DT.95235502 
    DT.99948360  DT.91759501 

    Selected AceView cDNA sequences (see all 285):

    BI915658 AX747297 CB153953 BU163743 CR617994 NM_001220 AA321802 AA349549 
    AF083419 AI342921 AI809976 CA842890 CR602724 BQ717785 AL134750 BU727885 
    BM544404 NM_172078 CA975907 AF081572 AW006092 NM_172081 CR602217 AJ709418 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CAMK2B (see all 15)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
    SP1:              -     -           -     -     -           -                                                                                                   
    SP2:              -     -           -     -     -           -                                                                             -                     
    SP3:              -     -           -     -     -           -                                                                             -                     
    SP4:              -     -           -     -     -           -                                                                             -                 -   
    SP5:              -     -           -     -     -           -                                                                             -           -     -   

    ExUns: 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29a · 29b ^ 30
    SP1:        -     -                                       
    SP2:        -     -                                       
    SP3:        -     -                                       
    SP4:        -     -                                       
    SP5:        -     -                                       


    ECgene alternative splicing isoforms for CAMK2B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CAMK2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGTGTCTG
    CAMK2B Expression
    About this image


    CAMK2B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Adult Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier
    CAMK2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CAMK2B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.351887

    UniProtKB/Swiss-Prot: KCC2B_HUMAN, Q13554
    Tissue specificity: Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal
    brain. Expressed in skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Array including CAMK2B: 
              Circadian Rhythms in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CAMK2B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Camk2b1 , 5 calcium/calmodulin-dependent protein kinase II, beta1, 5 91.5(n)1
    97.98(a)1
      11 (3.89 cM)5
    123231  NM_001174053.11  NP_001167524.11 
     59696445 
    chicken
    (Gallus gallus)
    Aves CAMK2B1 calcium/calmodulin-dependent protein kinase II beta 84.46(n)
    91.65(a)
      374174  NM_204294.1  NP_989625.1 
    lizard
    (Anolis carolinensis)
    Reptilia CAMK2B6
    calcium/calmodulin-dependent protein kinase II bet...
    79(a)
    1 ↔ 1
    GL343238.1(409826-584494)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.9872 Xenopus laevis calmodulin dependent protein kinase more 80.97(n)    U06636.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.125612 Transcribed sequence with moderate similarity to protein more 79.48(n)    BI429158.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CaMKII6
    Calcium/calmodulin-dependent protein kinase II
    73(a)
    1 → many
    4(1055914-1074329)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-436
    Protein UNC-43, isoform r (unc-43) mRNA, complete ...
    49(a)
    1 → many
    IV(10324317-10350217) WBGene00006779
    corn
    (Zea mays)
    Liliopsida Zm.18242 Zea mays PCO125082 mRNA sequence 73.73(n)    AY104819.1 


    ENSEMBL Gene Tree for CAMK2B (if available)
    TreeFam Gene Tree for CAMK2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CAMK2B gene
    PNCK2  CAMK1G2  PSKH22  DCX2  DCLK22  CAMK2A2  CAMK1D2  DCLK12  
    PSKH12  CAMK42  CAMK2D2  DCLK32  CAMKV2  CAMK2G2  CAMK12  
    Selected SIMAP similar genes for CAMK2B using alignment to 13 protein entries:     KCC2B_HUMAN (see all proteins) (see all similar genes):
    CAMK2D    CAMK2A    CAMK2G    CASK    DAPK3    BRSK1
    KIAA0999    Par1b    CDK4    SIK3    MARK1    MKNK1
    SNRK    DAPK1    MARK2    MYLK    RPS6KA6    STK11

    CAMK2B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for CAMK2B (see all 2208)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0455814
    A colorectal adenocarcinoma sample4--see VAR_0455812 P L mis40--------
    rs1496241281,2
    C--44259554(+) GGCAT-/GTGGCT 8 -- int10--------
    rs616527631,2
    C--44259557(+) ATGGCG/-TCTGC 8 -- int12Minor allele frequency- -:0.00NA CSA 8
    rs1387997331,2
    C--44259561(+) CTCTG-/CCACAG 8 -- int10--------
    rs617015631,2
    C--44259563(+) CTGCAC/-CAGGC 8 -- int12Minor allele frequency- -:0.00NA CSA 8
    rs3704578661,2
    C--44262042(+) TTTTT-/G/TAGATG 8 -- int10--------
    rs58838931,2
    C--44262441(+) CAGGTG/-GACTG 8 -- int11Minor allele frequency- -:0.00NA 2
    rs615876481,2
    C--44263186(+) CTTGAG/-GGCCC 8 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs1379023401,2
    C--44267355(+) GGGTG-/TGGGGGACA
    GAGGGAGAGTC
    TGGGG
    8 -- int10--------
    rs348059131,2
    C--44267366(+) AGAGG-/GAGAGT 8 -- int10--------

    HapMap Linkage Disequilibrium report for CAMK2B (44256749 - 44374176 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for CAMK2B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734322CNV Deletion23290073
    nsv509195CNV Insertion20534489
    esv2629662CNV Insertion19546169
    esv9227CNV Loss19470904
    esv22639CNV Loss19812545
    nsv887998CNV Loss21882294
    esv24646CNV Gain19812545
    nsv830984CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607707    OMIM disorders: --

    11 diseases for CAMK2B:    
    About MalaCards
    phencyclidine abuse    drug addiction    autism spectrum disorder    malignant glioma
    influenza    tuberculosis    schizophrenia    endotheliitis
    hiv-1    neuronitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for CAMK2B:
    Phencyclidine abuse

    CAMK2B for disorders           About GeneDecksing

    Genetic Association Database (GAD): CAMK2B
    Human Genome Epidemiology (HuGE) Navigator: CAMK2B (3 documents)

    Export disorders for CAMK2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for CAMK2B gene, integrated from 10 sources (see all 88):
    (articles sorted by number of sources associating them with CAMK2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. (PubMed id 22399527)1, 4 Kristiansson K....Salomaa V. (Circ Cardiovasc Genet 2012)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)
    4. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (Biol. Psychiatry 2009)
    5. Calmodulin-kinases: modulators of neuronal development and plasticity. (PubMed id 18817731)1, 2 Wayman G.A....Soderling T.R. (Neuron 2008)
    6. Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+- calmodulin-dependent protein kinase II. (PubMed id 14722083)1, 2 Gaertner T.R.... Waxham M.N. (J. Biol. Chem. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. (PubMed id 15312654)1, 2 Krapivinsky G.... Clapham D.E. (Neuron 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The role of calcium and calcium/calmodulin-dependent kinases in skeletal muscle plasticity and mitochondrial biogenesis. (PubMed id 15294044)1, 2 Chin E.R. (Proc. Nutrit. Soc. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 816 HGNC: 1461 AceView: CAMK2B Ensembl:ENSG00000058404 euGenes: HUgn816
    ECgene: CAMK2B Kegg: 816 H-InvDB: CAMK2B

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CAMK2B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CAMK2B gene:
    Search GeneIP for patents involving CAMK2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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