Aliases for CAMK2A Gene
- Calcium/Calmodulin-Dependent Protein Kinase II Alpha 2 3
- CAMKA 3 4 6
- Calcium/Calmodulin-Dependent Protein Kinase (CaM Kinase) II Alpha 2 3
- Calcium/Calmodulin-Dependent Protein Kinase Type II Alpha Chain 2 3
- Calcium/Calmodulin-Dependent Protein Kinase II Alpha-B Subunit 2 3
- CaM Kinase II Alpha Subunit 2 3
- CaM Kinase II Subunit Alpha 3 4
- CaM-Kinase II Alpha Chain 2 3
External Ids for CAMK2A Gene
Previous HGNC Symbols for CAMK2A Gene
Previous GeneCards Identifiers for CAMK2A Gene
The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]
GeneCards Summary for CAMK2A Gene
CAMK2A (Calcium/Calmodulin-Dependent Protein Kinase II Alpha) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include calmodulin binding and calmodulin-dependent protein kinase activity. An important paralog of this gene is DCX.
UniProtKB/Swiss-Prot for CAMK2A Gene
CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).
Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through autoinhibition. Increases in Ca2+ levels allows calmodulin to relieve this autoinhibition and activate the kinase activity. There are two main classes of CaMKs; mulitfunctional CaMKs (CaMKK, CaMKI, CaMKII and CaMKIV) which have multiple downstream targets and substrate-specific CaMKs (CaMKIII) which have only one known downstream target. All CaMKs, with the exception of CaMKII, exist as monomers and most are expressed ubiquitously. Some subtypes display specific distributions, for example, CaMKIVbeta is expressed exclusively in cerebellar granule cells. CaMKs have numerous cellular functions and they influence processes as diverse as gene transcription, cell survival, apoptosis, cytoskeletal re-organization and learning and memory.