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CAMK2A Gene(Protein Coding)

Calcium/Calmodulin Dependent Protein Kinase II Alpha

GCID:
GC05M150219
GIFtS:
69
Genes Participants
UDN Logo

Aliases for CAMK2A Gene

Aliases for CAMK2A Gene

  • Calcium/Calmodulin Dependent Protein Kinase II Alpha 2 3 5
  • Calcium/Calmodulin-Dependent Protein Kinase (CaM Kinase) II Alpha 2 3
  • Calcium/Calmodulin-Dependent Protein Kinase Type II Alpha Chain 2 3
  • Calcium/Calmodulin-Dependent Protein Kinase II Alpha-B Subunit 2 3
  • CaM Kinase II Alpha Subunit 2 3
  • CaM Kinase II Subunit Alpha 3 4
  • CaM-Kinase II Alpha Chain 2 3
  • CaMK-II Alpha Subunit 2 3
  • CaMK-II Subunit Alpha 3 4
  • EC 2.7.11.17 4 61
  • CAMKA 3 4
  • Calcium/Calmodulin-Dependent Protein Kinase Type II Subunit Alpha 3
  • CaMKIINalpha 3
  • EC 2.7.11 61
  • KIAA0968 4

External Ids for CAMK2A Gene

Previous HGNC Symbols for CAMK2A Gene

  • CAMKA

Previous GeneCards Identifiers for CAMK2A Gene

  • GC05M149669
  • GC05P150272
  • GC05M149582
  • GC05M149627
  • GC05M149579
  • GC05M144747

Summaries for CAMK2A Gene

Entrez Gene Summary for CAMK2A Gene

  • The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]

GeneCards Summary for CAMK2A Gene

CAMK2A (Calcium/Calmodulin Dependent Protein Kinase II Alpha) is a Protein Coding gene. Diseases associated with CAMK2A include Conduct Disorder. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and Development Endothelin-1/EDNRA signaling. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is CAMK2D.

UniProtKB/Swiss-Prot for CAMK2A Gene

  • CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity). Phosphorylates transcription factor FOXO3 on Ser-298 (PubMed:23805378). Activates FOXO3 transcriptional activity (By similarity).

Tocris Summary for CAMK2A Gene

  • Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through autoinhibition, which can be relieved by increases in Ca2+ levels.

Gene Wiki entry for CAMK2A Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMK2A Gene

Genomics for CAMK2A Gene

Products:

  1. Regulatory Element

Regulatory Elements for CAMK2A Gene

Enhancers for CAMK2A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G150316 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -29.9 -29856 8.0 FOXA2 CREB3L1 ARNT SIN3A FEZF1 ZNF766 FOS KLF13 REST SMARCB1 PDGFRB CAMK2A TCOF1 SLC6A7 CDX1 CSF1R SYNPO ARSI
GH05G150133 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +148.7 148678 15.5 PKNOX1 FOXA2 MLX CREB3L1 ARNT ARID4B DMAP1 FEZF1 YY1 ZNF766 CDX1 SLC6A7 CSF1R TCOF1 CAMK2A PDGFRB RPS14 SYNPO
GH05G150286 1 FANTOM5 dbSUPER 16.1 +4.1 4091 0.2 PKNOX1 ZNF394 ZIC2 OSR2 GATA3 PATZ1 KDM1A ZNF600 NR2C2 SLC6A7 CAMK2A PDGFRB TCOF1
GH05G150244 1.2 Ensembl ENCODE dbSUPER 9.4 +44.1 44144 3.9 ZNF263 NR2F1 NRF1 E2F5 MNT NFXL1 ZIC2 ZNF644 NR2F2 MEF2D CAMK2A SLC6A7
GH05G150121 1.1 Ensembl ENCODE 10.1 +167.9 167880 1.0 ATF1 ARID4B RAD21 RARA ZNF766 CREM ZNF263 ZBTB2 USF2 CEBPB PDGFRB CDX1 SLC6A7 HMGXB3 TIGD6 CAMK2A CSF1R
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CAMK2A on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CAMK2A gene promoter:

Genomic Location for CAMK2A Gene

Chromosome:
5
Start:
150,219,491 bp from pter
End:
150,290,291 bp from pter
Size:
70,801 bases
Orientation:
Minus strand

Genomic View for CAMK2A Gene

Genes around CAMK2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAMK2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAMK2A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CAMK2A Gene

Proteins for CAMK2A Gene

Products:

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  • Protein details for CAMK2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQM7-KCC2A_HUMAN
    Recommended name:
    Calcium/calmodulin-dependent protein kinase type II subunit alpha
    Protein Accession:
    Q9UQM7
    Secondary Accessions:
    • Q9UL21
    • Q9Y2H4
    • Q9Y352

    Protein attributes for CAMK2A Gene

    Size:
    478 amino acids
    Molecular mass:
    54088 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with BAALC, MPDZ, SYN1, CAMK2N2 and SYNGAP1. Interacts with SYNPO2 (By similarity).
    SequenceCaution:
    • Sequence=BAA76812.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CAMK2A Gene

    Alternative splice isoforms for CAMK2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAMK2A Gene

Protein Expression for CAMK2A Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for CAMK2A Gene

Q9UQM7:
  • WACGVILYILLVGYPPFWDEDQH
  • CLKKFNARRKLKGAILTT
  • NIVRLHD
  • KGAAVKLADFGLAIEV
  • GVILYIL
  • FPSPEWD
  • QAWFGFAGTPGYLSPEVL
  • WACGVIL
  • FEPEALGNLVEG
  • VTGGELF
  • VKLADFG
  • VHRDLKPENLLLASK
  • YSEADASHCIQQILE
  • TEQLIEA
  • VVHRDLK
  • QIKAGAYD
  • EALKHPWI
  • TTIEDED
  • PEAKDLI
  • PYGKPVD
  • LADFGLA
  • QSEETRVWH
  • HFHRSGAPSV
  • DFHRFYFEN
  • RKQEIIK
  • LKPENLL
  • RDLKPEN
  • GKGAFSVVRRC
  • AAKIINTKKL
  • EELGKGAFS
  • FNARRKL
  • NIVRLHDSISEEG
  • QKLEREARICR
  • VHRDLKP

Post-translational modifications for CAMK2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAMK2A Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CAMK2A Gene

Gene Families for CAMK2A Gene

IUPHAR :

Protein Domains for CAMK2A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CAMK2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UQM7

UniProtKB/Swiss-Prot:

KCC2A_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
genes like me logo Genes that share domains with CAMK2A: view

Function for CAMK2A Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CAMK2A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state.
UniProtKB/Swiss-Prot Function:
CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity). Phosphorylates transcription factor FOXO3 on Ser-298 (PubMed:23805378). Activates FOXO3 transcriptional activity (By similarity).

Enzyme Numbers (IUBMB) for CAMK2A Gene

Gene Ontology (GO) - Molecular Function for CAMK2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004683 calmodulin-dependent protein kinase activity IBA --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
genes like me logo Genes that share ontologies with CAMK2A: view
genes like me logo Genes that share phenotypes with CAMK2A: view

Animal Models for CAMK2A Gene

MGI Knock Outs for CAMK2A:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAMK2A Gene

Localization for CAMK2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMK2A Gene

Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse. Note=Postsynaptic lipid rafts. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CAMK2A gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
mitochondrion 4
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CAMK2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA --
GO:0005739 mitochondrion ISS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CAMK2A: view

Pathways & Interactions for CAMK2A Gene

SuperPathways for CAMK2A Gene

PathCards logo More details on SuperPathways for CAMK2A
SuperPathway Contained pathways
1 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
NCAM signaling for neurite out-growth
.89
DAP12 interactions
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.56
2 Post NMDA receptor activation events
Activation of NMDA receptor upon glutamate binding and postsynaptic events
.90
Post NMDA receptor activation events
.90
CREB phosphorylation through the activation of Ras
.78
CREB phosphorylation through the activation of CaMKII
.01
Ras activation uopn Ca2+ infux through NMDA receptor
.01
Unblocking of NMDA receptor, glutamate binding and activation
.01
3 Development Angiotensin activation of ERK
Development ACM2 and ACM4 activation of ERK
.73
Development Angiotensin activation of ERK
.73
Development Angiotensin signaling via PYK2
.68
Development G-Proteins mediated regulation MARK-ERK signaling
.65
Cell adhesion Integrin inside-out signaling
.45
Signal transduction IP3 signaling
.40
4 Development Endothelin-1/EDNRA signaling
Development Endothelin-1/EDNRA signaling
.41
Development Endothelin-1/EDNRA transactivation of EGFR
.41
Cytoskeleton remodeling FAK signaling
.41
GnRH signaling pathway
.38
Inflammatory mediator regulation of TRP channels
.38
5 Cardiac conduction
Cardiac conduction
.70
Muscle contraction
.70
Ion homeostasis
.39
Ion transport by P-type ATPases
.37
genes like me logo Genes that share pathways with CAMK2A: view

Pathways by source for CAMK2A Gene

1 GeneTex pathway for CAMK2A Gene
2 Cell Signaling Technology pathways for CAMK2A Gene
1 PharmGKB pathway for CAMK2A Gene

SIGNOR curated interactions for CAMK2A Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CAMK2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle ISS --
GO:0000165 MAPK cascade TAS --
GO:0002931 response to ischemia ISS --
GO:0006468 protein phosphorylation IEA,IDA 17052756
GO:0006816 calcium ion transport ISS --
genes like me logo Genes that share ontologies with CAMK2A: view

Drugs & Compounds for CAMK2A Gene

Products:

  1. Drug

(15) Drugs for CAMK2A Gene - From: DrugBank, ApexBio, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME} Experimental Pharma Target 0
1,4-Dithiothreitol Experimental Pharma Target 0
Hexatantalum Dodecabromide Experimental Pharma Target 0
KN-93 Phosphate Pharma CaM kinase II inhibitor, water soluble and cell permeable, CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278). 0
Autocamtide-2-related inhibitory peptide Pharma inhibitor of calmodulin-dependent protein kinase II (CaM-kinase II, CaMKII) 0

(5) Additional Compounds for CAMK2A Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Autocamtide-2-related inhibitory peptide, myristoylated
201422-04-0
KN 93
139298-40-1

(5) Tocris Compounds for CAMK2A Gene

Compound Action Cas Number
A 484954 CaM kinase III (eEF-2 kinase) inhibitor 142557-61-7
Autocamtide-2-related inhibitory peptide, myristoylated CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptide 201422-04-0
KN 93 CaM kinase II inhibitor; also K+ channel blocker (KV) 139298-40-1
KN 93 phosphate CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278). 1188890-41-6
STO-609 acetate Selective CaM kinase kinase inhibitor 1173022-21-3

(8) ApexBio Compounds for CAMK2A Gene

Compound Action Cas Number
Autocamtide-2-related inhibitory peptide inhibitor of calmodulin-dependent protein kinase II (CaM-kinase II, CaMKII) 167114-91-2
CaMKII-IN-1 1208123-85-6
KN-62 CaM kinase II inhibitor 127191-97-3
KN-92 CaMKII inhibitor 176708-42-2
KN-92 phosphate CaMKII inhibitor 1135280-28-2
KN-93 CaMKII inhibitor,selective and cometitive 139298-40-1
KN-93 hydrochloride CaMK II inhibitor
KN-93 Phosphate CaM kinase II inhibitor, water soluble and cell permeable 1188890-41-6
genes like me logo Genes that share compounds with CAMK2A: view

Transcripts for CAMK2A Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CAMK2A Gene

(3) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(101) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CAMK2A Gene

Calcium/calmodulin-dependent protein kinase II alpha:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAMK2A Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - - -
SP2: - - -
SP3:
SP4: - - - -
SP5: - - -
SP6: -
SP7: -

ExUns: 20 ^ 21
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for CAMK2A Gene

GeneLoc Exon Structure for
CAMK2A
ECgene alternative splicing isoforms for
CAMK2A

Expression for CAMK2A Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CAMK2A Gene

mRNA expression in normal human tissues for CAMK2A Gene
mRNA expression by BioGPS for CAMK2A GenemRNA expression by GTEx for CAMK2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAMK2A Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x11.0), Brain - Cortex (x9.0), Brain - Anterior cingulate cortex (BA24) (x8.9), Brain - Hippocampus (x7.7), and Brain - Amygdala (x6.0).

Protein differential expression in normal tissues from HIPED for CAMK2A Gene

This gene is overexpressed in Brain (37.5) and Frontal cortex (26.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CAMK2A Gene



Protein tissue co-expression partners for CAMK2A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CAMK2A Gene:

CAMK2A

SOURCE GeneReport for Unigene cluster for CAMK2A Gene:

Hs.743976

Evidence on tissue expression from TISSUES for CAMK2A Gene

  • Nervous system(5)
genes like me logo Genes that share expression patterns with CAMK2A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAMK2A Gene

Orthologs for CAMK2A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAMK2A Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
 Mammalia CAMK2A 35
  • 99 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia CAMK2A 34 35
  • 98.51 (n)
cow
(Bos Taurus)
 Mammalia CAMK2A 34 35
  • 93.93 (n)
rat
(Rattus norvegicus)
 Mammalia Camk2a 34
  • 93.38 (n)
mouse
(Mus musculus)
 Mammalia Camk2a 34 16 35
  • 93.03 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia CAMK2A 35
  • 93 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia CAMK2A 34 35
  • 92.91 (n)
chicken
(Gallus gallus)
 Aves CAMK2A 34 35
  • 86.61 (n)
lizard
(Anolis carolinensis)
 Reptilia CAMK2A 35
  • 94 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia camk2a 34
  • 79.69 (n)
zebrafish
(Danio rerio)
 Actinopterygii camk2a 34 35
  • 81.02 (n)
fruit fly
(Drosophila melanogaster)
 Insecta CaMKII 36 35
  • 71 (a)
worm
(Caenorhabditis elegans)
 Secernentea unc-43 35
  • 48 (a)
 OneToMany
rice
(Oryza sativa)
 Liliopsida Os11g0136600 34
  • 49.95 (n)
Species where no ortholog for CAMK2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAMK2A Gene

ENSEMBL:
Gene Tree for CAMK2A (if available)
TreeFam:
Gene Tree for CAMK2A (if available)

Paralogs for CAMK2A Gene

Variants for CAMK2A Gene

Sequence variations from dbSNP and Humsavar for CAMK2A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs864309606 Uncertain significance 150,250,800(-) ATCGC(C/T)GGAAT reference, missense
rs1000062059 -- 150,256,171(+) GCAGA(A/G)GTTGC intron-variant
rs1000074503 -- 150,270,455(+) AGAGG(C/T)TGGGC intron-variant
rs1000142892 -- 150,270,291(+) AGCTC(C/T)CAAAG intron-variant
rs1000228684 -- 150,231,197(+) CACAT(A/G)CAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAMK2A Gene

Variant ID Type Subtype PubMed ID
esv2675470 CNV deletion 23128226
esv2730912 CNV deletion 23290073
esv2730913 CNV deletion 23290073
esv2763509 CNV gain 21179565
esv3890752 CNV loss 25118596
nsv1137037 CNV deletion 24896259
nsv1140580 CNV deletion 24896259
nsv479095 CNV novel sequence insertion 20440878
nsv524540 CNV loss 19592680
nsv525244 CNV loss 19592680

Variation tolerance for CAMK2A Gene

Residual Variation Intolerance Score: 15.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.06; 1.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAMK2A Gene

Human Gene Mutation Database (HGMD)
CAMK2A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CAMK2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMK2A Gene

Disorders for CAMK2A Gene

MalaCards: The human disease database

(1) MalaCards diseases for CAMK2A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
conduct disorder
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CAMK2A

Genetic Association Database (GAD)
CAMK2A
Human Genome Epidemiology (HuGE) Navigator
CAMK2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAMK2A
genes like me logo Genes that share disorders with CAMK2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAMK2A Gene

Publications for CAMK2A Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PMID: 19156168) Need A.C. … Goldstein D.B. (Eur. J. Hum. Genet. 2009) 3 46 64
  4. Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. (PMID: 19328558) Yosifova A. … Nakamura Y. (J Affect Disord 2009) 3 46 64
  5. The expression of calcium/calmodulin-dependent protein kinase II-alpha in the hippocampus of patients with Alzheimer's disease and its links with AD-related pathology. (PMID: 15621017) Wang Y.J. … Liu R.Y. (Brain Res. 2005) 3 22 64

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Sources for CAMK2A Gene

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