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CAMK2A Gene

protein-coding GIFtS: 69

GC05M149579

calcium/calmodulin-dependent protein kinase II alpha
(Previous name: calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CAMKA)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CAMKA ^², ³, ⁵
CaMKIINalpha ^¹, ²
EC 2.7.11.17 ^³
KIAA0968 ^¹, ², ³, ⁵
OTTHUMP00000165787 ^²
OTTHUMP00000165788 ^²

Descriptions
CaM kinase II alpha subunit ^²
CaM kinase II subunit alpha ^³
CaM-kinase II alpha chain ^², ³
CaMK-II alpha subunit ^²
CaMK-II subunit alpha ^³
calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha ^¹, ²
calcium/calmodulin-dependent protein kinase II alpha ^²
calcium/calmodulin-dependent protein kinase II alpha-B subunit ^²
calcium/calmodulin-dependent protein kinase type II alpha chain ^²

External Ids
HGNC: 1460¹
Entrez Gene: 815²
UniProtKB: Q9UQM7³
Ensembl: ENSG00000070808⁷

Search outside databases for aliases for CAMK2A gene

Previous GC identifers: GC05M149669 GC05P150272 GC05M149582 GC05M149627

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CAMK2A:

The product of this gene belongs to the serine/threonine protein kinases family, and to the

Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several

aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase

is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by

this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In

addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo

autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding

distinct isoforms have been identified for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: KCC2A_HUMAN, Q9UQM7

Function: CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may

function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling

complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and

synaptic plasticity (By similarity)

Gene Wiki entry for CAMK2A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CAMK2A gene

Entrez Gene cytogenetic band: 5q33.1 Ensembl cytogenetic band: 5q33.1 HGNC chromosome: 5

CAMK2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M149579: (about GC identifiers)

Start:	149,579,247 bp from pter
End:	149,650,047 bp from pter
Size:	70,801 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000005.8 NT_029289.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: KCC2A_HUMAN, Q9UQM7 (See protein sequence)

Recommended Name: Calcium/calmodulin-dependent protein kinase type II alpha chain

Size: 478 amino acids; 54030 Da

Subunit: CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different

isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits.

Interacts with BAALC, MPDZ, SYN1, CAMK2N2 and SYNGAP1 (By similarity)

Subcellular location: Cell junction, synapse, presynaptic cell membrane (By similarity). Cell

junction, synapse (By similarity). Note=Postsynaptic lipid rafts (By similarity)

PDB structures from and Proteopedia :

2VZ6 (3D)

Secondary accessions: Q9UL21 Q9Y2H4 Q9Y352

Alternative splicing: 2 isoforms: Q9UQM7-1 Q9UQM7-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_057065.2 NP_741960.1

ENSEMBL proteins:

ENSP00000381412 ENSP00000261793 ENSP00000305090 ENSP00000381411

Human Recombinant Proteins

	Invitrogen human recombinant proteins for CAMK2A
	Millipore Purified and/or Recombinant CAMK2A Protein
	Sigma-Aldrich Proteins and AQUA Peptides for CAMK2A
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for CAMK2A
	Recombinant Proteins from Abcam (CaMKII, CaMKII alpha )
	Human Recombinant Proteins from Abnova (CAMK2A)

OriGene Purified Recombinant Human Proteins (see all 2): CAMK2A

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0030054	cell junction	IEA	--
GO:0045202	synapse	IEA	--

About this table

Antibodies for CAMK2A:

	Invitrogen Antibodies for CAMK2A
	Millipore Mono- and Polyclonal Antibodies for the study of CAMK2A
	Sigma-Aldrich Antibody Arrays and Antibodies for CAMK2A
	R&D Systems Antibodies for CAMK2A (CaM Kinase II alpha)
	Cell Signaling Technology (CST) Antibodies for CAMK2A (CaMKII-alpha, CaMK2-alpha)
	Antibodies from Abcam (CaMKII, CaMKII alpha ), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CAMK2A)
	Novus Biologicals Antibodies for CAMK2A

Assays for CAMK2A:

	Invitrogen Assays for CAMK2A
	Millipore Kits and Assays for the Analysis of CAMK2A
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9UQM7

ProtoNet protein and cluster: Q9UQM7

1 Blocks protein family: IPB013543 Calcium/calmodulin dependent protein kinase II

UniProtKB/Swiss-Prot: KCC2A_HUMAN, Q9UQM7

Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK

subfamily

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CAMK2A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CAMK2A)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_171825

Applied Biosystems Silencer® siRNAs for CAMK2A

Sigma-Aldrich siRNA and siRNA Panels for CAMK2A

Sigma-Aldrich shRNA Panels and shRNA for CAMK2A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CAMK2A
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_015981
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_015981
untagged cDNA clones in CMV expression vector (see all 4): NM_015981

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_015981

UniProtKB/Swiss-Prot: KCC2A_HUMAN, Q9UQM7

Function: CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may

function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling

complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and

synaptic plasticity (By similarity)

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme regulation: Autophosphorylation of Thr-286 allows the kinase to switch from a

calmodulin-dependent to a calmodulin-independent state (By similarity)

Enzyme Number (IUBMB): EC 2.7.11.17

4 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Camk2a):

behavior/neurological

homeostasis/metabolism

nervous system

skin/coat/nails

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004683	calmodulin-dependent protein kinase activity	IEA	--
GO:0005516	calmodulin binding	IEA	--
GO:0005524	ATP binding	IC	17052756
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/16 Sigma-Aldrich "Your Favorite Gene" Pathways for CAMK2A (Your Favorite Gene powered by Ingenuity) (see all 16 )

CREB Signaling in Neurons
iCOS-iCOSL Signaling in T Helper Cells
Chemokine Signaling
Xenobiotic Metabolism Signaling
Thrombin Signaling

GeneDecks CAMK2A for the pathways selected above

About GeneDecksing

5/62 Interacting proteins for CAMK2A (Q9UQM7^{1, 2} ENSP00000305090³) via UniProtKB, MINT, and/or STRING (see all 62 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CAMK2D	Q13557¹, ENSP00000339740³	EBI-1383687, EBI-351018 STRING (score=.928)
CALM1	P62158¹, ENSP00000349467³	EBI-1383687, EBI-397435 STRING (score=.8)
GRIA4	P48058², ENSP00000282499³	MINT-17826 STRING (score=.732)
CHMP5	Q9NZZ3¹	EBI-1383687, EBI-751303
DLG3	Q92796¹	EBI-1383687, EBI-80440

About this table

5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000082	G1/S transition of mitotic cell cycle	IEA	--
GO:0006816	calcium ion transport	IEA	--
GO:0046777	protein amino acid autophosphorylation	IEA	--
GO:0046928	regulation of neurotransmitter secretion	IEA	--
GO:0048168	regulation of neuronal synaptic plasticity	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for CAMK2A

Sigma-Aldrich Small Molecules for CAMK2A:

Antagonist

Compounds for CAMK2A available from Tocris Bioscience

Compound	Action	CAS number
KN-62	Non-competitive P2X7 antagonist	[127191-97-3]
KN-93	CaM kinase II inhibitor. Also K+ channel blocker (KV)	[139298-40-1]
Autocamtide-2-related inhibitory peptide	Selective CaM kinase II inhibitor	[167114-91-2]
Arcyriaflavin A	Potent cdk4/cyclin D1 and CaM Kinase II inhibitor. Antiviral agent (anti-HCMV)	[118458-54-1]

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3 Novoseek chemical compound relationships for CAMK2A gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
calcium	32.00	7	15621017 (2), 18495661 (2), 19291219 (1), 8259515 (1)
glycogen	19.71	1	8639633 (1)
atp	0.00	2	8391850 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CAMK2A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CAMK2A)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_171825

Sigma-Aldrich siRNA and siRNA Panels for CAMK2A

Sigma-Aldrich shRNA Panels and shRNA for CAMK2A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_015981 NM_171825

REFSEQ mRNAs for CAMK2A gene (2 alternative transcripts):

NM_015981.3 NM_171825.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_015981 NM_171825

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_015981
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_015981
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_015981

Additional cDNA sequence:

AB023185.1 AF091486.1 AF145710.1 AF145711.1 AK289776.1 AK308853.1 AY429524.1 BC040457.1

BC114359.1 CR612614.1 CR613519.1

8 DOTS entries:

DT.75101681 DT.92434464 DT.120799253 DT.120799251 DT.120799245 DT.92434462 DT.120799383 DT.95374686

24/101 AceView cDNA sequences (see all 101 ):

AA358854 NM_171825 AW899403 CR613519 AW899421 AF091486 BE699884 AA410892

NM_015981 AY429524 CR612614 AL119079 AL520649 AW297106 BM545485 BM805444

BG699401 AI039803 AL520283 BE700157 BI545062 AB023185 BX349890 AA419536

highest scoring ESTs for CAMK2A:

AB023185 AF091486 AF145710 AF145711 AL120516 BC040457 BF943763 BG699401 BI545062 BI545648

Unigene Cluster for CAMK2A:

Calcium/calmodulin-dependent protein kinase II alpha

Hs.716391 [show with all ESTs]

Unigene Representative Sequence: NM_015981

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CAMK2A (see all 7 )

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9a	·	9b	·	9c	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b	^	16	^	17	^	18	^	19	^
SP1:													-		-																										-				-
SP2:													-		-																										-
SP3:
SP4:			-		-								-		-
SP5:													-		-		-

ExUns:	20	^	21
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for CAMK2A

4 Ensembl transcripts including schematic representations:

ENST00000398376 ENST00000348628 ENST00000351010 ENST00000398374

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CAMK2A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CAMK2A

¹ / ² / ³

5 probe-sets matching CAMK2A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
31813_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AB023185	1.00	1.00	1.00	1
213108_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AW131813	0.60	1.00	0.82	1
207613_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_015981	0.60	1.00	0.82	1
213108_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207613_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CAMK2A for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTGCGAATCC

SOURCE GeneReport for Unigene cluster: Hs.716391
Expression variation in blood from EXPOLDB for CAMK2A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CAMK2A gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CAMK2A¹	--	calcium/calmodulin-dependent protein kinase II alpha	92.8(n) 99.79(a)	612941 XM_862527.1 XP_867620.1
chimpanzee (Pan troglodytes)	CAMK2A¹	--	calcium/calmodulin-dependent protein kinase II alpha	96.16(n) 95.82(a)	462189 XM_001165329.1 XP_001165329.1
cow (Bos taurus)	CAMK2A¹	--	calcium/calmodulin-dependent protein kinase II alpha	93.93(n) 99.79(a)	530719 NM_001075938.1 NP_001069406.1
rat (Rattus norvegicus)	Camk2a¹	--	calcium/calmodulin-dependent protein kinase II alpha	93.38(n) 99.79(a)	25400 NM_012920.1 NP_037052.1
mouse (Mus musculus)	Camk2a^{1, 5}	18 (33.00 cM)⁵	calcium/calmodulin-dependent protein kinase II alpha^{1, 5}	93.03(n)¹ 99.79(a)¹	12322¹ NM_177407.3¹ NP_803126.1¹ AK083245⁵ AK122410⁵ (see all 11)

About this table Species with no ortholog for CAMK2A

ENSEMBL Gene Tree for CAMK2A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CAMK2A gene

PHKG2² PHKG1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/437 NCBI SNPs in CAMK2A are shown (see all 437 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 185)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3806948^1,2	A,C,F,H	149651444(-)	`GGAGGG/TTCAGA`	2	--	ng3¹		6	EU EA NA	442
	rs873592^1,2	A,C,F,H	149649949(-)	`TCATTC/TGTTCC`	2	--	ng3¹		14	EU EA WA MN	2510
	rs6869490^1,2	A,C,F,H	149580641(+)	`GTGATC/TGGGGA`	2	--	ut3¹		4	EU EA WA	420
	rs873593^1,2	A,C,F,H	149649664(-)	`GTTTCG/ACAGTG`	2	--	ng3¹		3	EU MN EA	1372
	rs2163766^1,2	A,C,F,H	149579741(+)	`CTGCCG/ACATCA`	2	--	ut3¹		8	EU EA WA	840
	rs6882623^1,2	A,C,F,H	149579567(+)	`CCTGTA/GAACGT`	2	--	ut3¹		4	EU EA WA	420
	rs11950723^1,2	C,F,H	149579086(+)	`CCAGGC/AATAAT`	2	--	ng5¹		4	EU EA WA	420
--	rs957709^1,2	A,C,F	149582019(+)	`TCATCT/CGCCCT`	2	--	ut3¹		4	MN NA	324
	rs7732895^1,2	C,F,H	149581458(+)	`AGTCCG/ACCTTG`	2	--	ut3¹		8	EU EA WA	832
	rs3806947^1,2	C,F,H	149651516(-)	`ACTTCG/ATGGGG`	2	--	ng3¹		4	EU EA WA	416

About this table

HapMap Linkage Disequilibrium images for CAMK2A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 114078

Human Genome Epidemiology Navigator: CAMK2A (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/123 PubMed articles for CAMK2A gene (see all 123 ):

Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)^{2, 3, 4} Nagase T....Ohara O. (1999)
SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. (PubMed id 15312654)^{3, 4} Krapivinsky G.... Clapham D.E. (2004)
Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase. (PubMed id 3475713)^{2, 3} Lin C.R....Rosenfeld M.G. (1987)
The expression of calcium/calmodulin-dependent protein kinase II-alpha in the hippocampus of patients with Alzheimer's disease and its links with AD-related pathology. (PubMed id 15621017)^{1, 3} Wang Y.J....Liu R.Y. (2005)
Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)³ Need A.C....Goldstein D.B. (2009)
Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. (PubMed id 19328558)³ Yosifova A....Nakamura Y. (2009)
A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization. (PubMed id 18305109)³ Wang C....Cao X. (2008)
Tumor necrosis factor-alpha enhances neutrophil adhesiveness: induction of vascular cell adhesion molecule-1 via activation of Akt and CaM kinase II and modifications of histone acetyltransferase and histone deacetylase 4 in human tracheal smooth muscle cells. (PubMed id 18227124)³ Lee C.W....Yang C.M. (2008)
Identification of the RA response element and transcriptional silencer in human alphaCaMKII promoter. (PubMed id 17221287)³ Wang L.... Hu Y. (2008)
Effect of endurance exercise training on Ca2+ calmodulin-dependent protein kinase II expression and signalling in skeletal muscle of humans. (PubMed id 17627985)³ Rose A.J....Richter E.A. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 815	HGNC: 1460	AceView: CAMK2A	Ensembl:ENSG00000070808	euGenes: HUgn815
ECgene: CAMK2A	H-InvDB: CAMK2A

(According to HUGE)
About This Section

HUGE: KIAA0968

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for CAMK2A
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CAMK2A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CAMK2A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CAMK2A		Antibodies for CAMK2A
	Explore super-pooled esiRNAs		Proteins for CAMK2A
	Lentivirus-delivered shRNAs for CAMK2A		Small molecules for CAMK2A
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CAMK2A)
	Antibodies (CAMK2A)
	Chimera RNAi (CAMK2A)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for CAMK2A (CaMKII-alpha, CaMK2-alpha)

	Recombinant Proteins (CaMKII, CaMKII alpha )
	Antibodies (CaMKII, CaMKII alpha )

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for CAMK2A

	Drugs/Proteins for CAMK2A
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CAMK2A

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CAMK2A Gene at Home site.
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CAMK2A Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for CAMK2A

Summaries
for CAMK2A

Genomic Location
for CAMK2A

Proteins
for CAMK2A

Protein Domains/
Families
for CAMK2A

Gene Function
for CAMK2A

Pathways & Interactions
for CAMK2A

Drugs & Compounds
for CAMK2A

Transcripts
for CAMK2A

Expression
for CAMK2A

Orthologs
for CAMK2A

Paralogs
for CAMK2A

SNPs/Variants
for CAMK2A

Disorders & Mutations
for CAMK2A

Medical News
for CAMK2A

Publications
for CAMK2A

Search for CAMK2A

Genome Databases showing CAMK2A

Other Databases showing CAMK2A

Specialized Databases showing CAMK2A

Licensable Technologies
for CAMK2A

Services
for CAMK2A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CAMK2A Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor CAMK2A

Summariesfor CAMK2A

Genomic Locationfor CAMK2A

Proteinsfor CAMK2A

Protein Domains/Familiesfor CAMK2A

Gene Functionfor CAMK2A

Pathways & Interactionsfor CAMK2A

Drugs & Compoundsfor CAMK2A

Transcriptsfor CAMK2A

Expression for CAMK2A

Orthologsfor CAMK2A

Paralogsfor CAMK2A

SNPs/Variantsfor CAMK2A

Disorders & Mutationsfor CAMK2A

Medical Newsfor CAMK2A

Publicationsfor CAMK2A

Search for CAMK2A

Genome Databases showing CAMK2A

Other Databases showing CAMK2A

Specialized Databases showing CAMK2A

Licensable Technologiesfor CAMK2A

Servicesfor CAMK2A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CAMK2A

Summaries
for CAMK2A

Genomic Location
for CAMK2A

Proteins
for CAMK2A

Protein Domains/
Families
for CAMK2A

Gene Function
for CAMK2A

Pathways & Interactions
for CAMK2A

Drugs & Compounds
for CAMK2A

Transcripts
for CAMK2A

Expression
for CAMK2A

Orthologs
for CAMK2A

Paralogs
for CAMK2A

SNPs/Variants
for CAMK2A

Disorders & Mutations
for CAMK2A

Medical News
for CAMK2A

Publications
for CAMK2A

Licensable Technologies
for CAMK2A

Services
for CAMK2A