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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CAMK2A Gene

protein-coding   GIFtS: 69
GCID: GC05M149579

calcium/calmodulin-dependent protein kinase II alpha

(Previous name: calcium/calmodulin-dependent protein kinase (CaM kinase)...)
(Previous symbol: CAMKA)
 Explore 16 diseases affiliated with
CAMK2A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CAMK2A    

Aliases
for CAMK2A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Calcium/Calmodulin-Dependent Protein Kinase II Alpha1 2     Calcium/Calmodulin-Dependent Protein Kinase II Alpha-B Subunit2
CAMKA1 2 3 5     Calcium/Calmodulin-Dependent Protein Kinase Type II Alpha Chain2
KIAA09681 3 5     Calcium/Calmodulin-Dependent Protein Kinase Type II Subunit Alpha2
CaMKIINalpha1 2     CaM Kinase II Alpha Subunit2
Calcium/Calmodulin-Dependent Protein Kinase (CaM Kinase) II Alpha1 2     CaM-Kinase II Alpha Chain2
CaM Kinase II Subunit Alpha2 3     CaMK-II Alpha Subunit2
CaMK-II Subunit Alpha2 3     EC 2.7.118
EC 2.7.11.173 8     

External Ids:    HGNC: 14601   Entrez Gene: 8152   Ensembl: ENSG000000708087   OMIM: 1140785   UniProtKB: Q9UQM73   

Export aliases for CAMK2A gene to outside databases

Previous GC identifers: GC05M149669 GC05P150272 GC05M149582 GC05M149627 GC05M144747


Summaries
for CAMK2A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CAMK2A:
The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent
protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses.
This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta.
The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In
addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting
in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene.
(provided by RefSeq, Nov 2008)

UniProtKB/Swiss-Prot: KCC2A_HUMAN, Q9UQM7
Function: CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term
potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may
regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity)

summary for CAMK2A:
Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second
messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through
autoinhibition. Increases in Ca2+ levels allows calmodulin to relieve this autoinhibition and activate the
kinase activity. There are two main classes of CaMKs; mulitfunctional CaMKs (CaMKK, CaMKI, CaMKII and
CaMKIV) which have multiple downstream targets and substrate-specific CaMKs (CaMKIII) which have only one
known downstream target. All CaMKs, with the exception of CaMKII, exist as monomers and most are expressed
ubiquitously. Some subtypes display specific distributions, for example, CaMKIVbeta is expressed exclusively
in cerebellar granule cells. CaMKs have numerous cellular functions and they influence processes as diverse
as gene transcription, cell survival, apoptosis, cytoskeletal re-organization and learning and memory.

Gene Wiki entry for CAMK2A


Genomic Views
for CAMK2A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_029289.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CAMK2A gene promoter:
         HOXA9B   HOXA9   ER-alpha   Pax-5   Nkx2-5   Tal-1beta   AREB6   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CAMK2A promoter sequence
   Search SABiosciences Chromatin IP Primers for CAMK2A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAMK2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32   Ensembl cytogenetic band:  5q32   HGNC chromosome: 5

CAMK2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAMK2A gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M149579:  view genomic region     (about GC identifiers)

Start:
 149,599,054 bp from pter      End:
 149,669,854 bp from pter
Size:
 70,801 bases      Orientation:
 minus strand

Proteins
for CAMK2A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KCC2A_HUMAN, Q9UQM7 (See protein sequence)
Recommended Name: Calcium/calmodulin-dependent protein kinase type II subunit alpha  
Size: 478 amino acids; 54088 Da
Subunit: CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble
into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with BAALC, MPDZ, SYN1, CAMK2N2 and
SYNGAP1 (By similarity)
Subcellular location: Cell junction, synapse, presynaptic cell membrane (By similarity). Cell junction, synapse (By
similarity). Note=Postsynaptic lipid rafts (By similarity)
Sequence caution: Sequence=BAA76812.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from and Proteopedia for CAMK2A:
2VZ6 (3D)        3SOA (3D)    
Secondary accessions: Q9UL21 Q9Y2H4 Q9Y352
Alternative splicing: 2 isoforms:  Q9UQM7-1   Q9UQM7-2   

Explore the universe of human proteins at neXtProt for CAMK2A: NX_Q9UQM7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UQM7

    • 4/34 DME Specific Peptides for CAMK2A (Q9UQM7) (see all 34)
     TEQLIEA  VVHRDLK  TTIEDED  PEAKDLI 

    CAMK2A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_057065.2  NP_741960.1  

    ENSEMBL proteins: 
     ENSP00000261793   ENSP00000381412   ENSP00000427580   ENSP00000426607  
    Reactome Protein details: Q9UQM7
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant CAMK2A Protein
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    OriGene Purified Protein: CAMK2A
    OriGene Protein Over-expression Lysate: CAMK2A
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    Novus Biologicals CAMK2A Proteins
    Novus Biologicals CAMK2A Lysates
    Sino Biological Recombinant Protein for CAMK2A
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0030054cell junction IEA--
    GO:0030666endocytic vesicle membrane TAS--


    CAMK2A for ontologies           About GeneDecksing



    CAMK2A Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CAMK2A
    R&D Systems Antibodies for CAMK2A (CaM Kinase II alpha)
    Cell Signaling Technology (CST) Antibodies for CAMK2A  (CaMK2-alpha)
    OriGene Antibodies (see all 3): CAMK2A
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    Abcam antibodies for CAMK2A 
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    ThermoFisher Antibodies for CAMK2A

    Assay Products for CAMK2A: 
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    GenScript Custom Assay Services for CAMK2A
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for CAMK2A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CAMK2A for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9UQM7

    ProtoNet protein and cluster: Q9UQM7

    1 Blocks protein family: IPB013543 Calcium/calmodulin dependent protein kinase II

    UniProtKB/Swiss-Prot: KCC2A_HUMAN, Q9UQM7
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for CAMK2A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KCC2A_HUMAN, Q9UQM7
    Function: CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term
    potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may
    regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a
    calmodulin-independent state (By similarity)

    Enzyme Numbers (IUBMB): EC 2.7.11.171 2 EC 2.7.112

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAMK2A
    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate CAMK2A (see all 58):
    hsa-miR-21* hsa-miR-142-5p hsa-miR-25 hsa-miR-128 hsa-miR-578 hsa-miR-507 hsa-miR-4267 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmid: CAMK2A 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAMK2A (see all 7)
    OriGene shRNA RFP: CAMK2A
    OriGene siRNA: CAMK2A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAMK2A

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAMK2A (see all 5)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): CAMK2A (NM_015981)
    Sino Biological Human cDNA Clone for CAMK2A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAMK2A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMK2A 

    Cell Line
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    Search LifeMap BioReagents cell lines for CAMK2A

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMK2A

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004683calmodulin-dependent protein kinase activity IEA--
    GO:0005515protein binding IPI17052756
    GO:0005516calmodulin binding IEA--
    GO:0005524ATP binding IEA--


    CAMK2A for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CAMK2A:
     Decreased telomerase activity 

    Animal Models:
         Mouse knock-outs for CAMK2A: Camk2atm1Sva Camk2atm3Sva
         5 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Camk2a):
     behavior/neurological  homeostasis/metabolism  integument  mortality/aging  nervous system 

    CAMK2A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CAMK2A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/56 super-pathways (see all 56) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development Angiotensin activation of ERK
    		Development Angiotensin activation of ERK1.00
    		Development_G-Proteins mediated regulation MARK-ERK signaling0.66
    		Development_Angiotensin activation of ERK0.98
    		Development G-Proteins mediated regulation MARK-ERK signaling0.66
    		Development_ACM2 and ACM4 activation of ERK0.74
    		Cholinergic synapse0.30
    		Development ACM2 and ACM4 activation of ERK0.74
    2Development_Endothelin-1/EDNRA transactivation of EGFR
    		Development_Endothelin-1/EDNRA transactivation of EGFR1.00
    		Development_Endothelin-1/EDNRA signaling0.41
    		Development Endothelin-1/EDNRA transactivation of EGFR1.00
    		Cytoskeleton remodeling_FAK signaling0.41
    		Development Endothelin-1/EDNRA signaling0.41
    		Cytoskeleton remodeling FAK signaling0.41
    3Translation_Translation regulation by Alpha-1 adrenergic receptors
    		Translation_Translation regulation by Alpha-1 adrenergic receptors1.00
    		Development_Activation of ERK by Alpha-1 adrenergic receptors0.64
    		Translation Translation regulation by Alpha-1 adrenergic receptors1.00
    		Development Activation of ERK by Alpha-1 adrenergic receptors0.64
    4Immune response_IFN gamma signaling pathway
    		Immune response_IFN gamma signaling pathway1.00
    		IFN-gamma pathway0.43
    		Immune response IFN gamma signaling pathway1.00
    5CREB phosphorylation through the activation of CaMKII
    		CREB phosphorylation through the activation of CaMKII1.00
    		Unblocking of NMDA receptor, glutamate binding and activation0.68
    		Ras activation uopn Ca2+ infux through NMDA receptor0.78

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/18 EMD Millipore Pathways for CAMK2A (see all 18)
        Translation Translation regulation by Alpha-1 adrenergic receptors
    Development Activation of ERK by Alpha-1 adrenergic receptors
    Cytoskeleton remodeling FAK signaling
    Signal transduction IP3 signaling
    Cell adhesion Integrin inside-out signaling

    1 R&D Systems Pathway for CAMK2A
        Wnt Signaling Pathway

    5/18 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CAMK2A (see all 18)
        Molecular Mechanisms of Cancer
    PI3K Signaling in B-Lymphocyte
    Melatonin Signaling
    IP3 Pathway
    CREB Pathway

    2 Cell Signaling Technology (CST) Pathways for CAMK2A
        Ca, cAMP and Lipid Signaling
    Neuroscience

    5/18 GeneGo (Thomson Reuters) Pathways for CAMK2A (see all 18)
        Development Endothelin-1/EDNRA transactivation of EGFR
    Signal transduction cAMP signaling
    Development Endothelin-1/EDNRA signaling
    Development Angiotensin signaling via PYK2
    Development Activation of ERK by Alpha-1 adrenergic receptors

    5/13 BioSystems Pathways for CAMK2A (see all 13) 
        EGFR1 Signaling Pathway
    Myometrial Relaxation and Contraction Pathways
    Calcium Regulation in the Cardiac Cell
    ErbB signaling pathway
    Integrated Pancreatic Cancer Pathway

    5/15        Reactome Pathways for CAMK2A (see all 15)
        Ras activation uopn Ca2+ infux through NMDA receptor
    Interferon gamma signaling
    Unblocking of NMDA receptor, glutamate binding and activation
    CREB phosphorylation through the activation of CaMKII
    Cytokine Signaling in Immune system

    1 PharmGKB Pathway for CAMK2A
        EGFR Inhibitor Pathway, Pharmacodynamics

    5/13         Kegg Pathways  (Kegg details for CAMK2A) (see all 13):
        ErbB signaling pathway
    Calcium signaling pathway
    Oocyte meiosis
    Wnt signaling pathway
    Long-term potentiation


    CAMK2A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CAMK2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/129 Interacting proteins for CAMK2A (Q9UQM72, 3 ENSP000003814124) via UniProtKB, MINT, STRING, and/or I2D (see all 129)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRIN2BQ132242, 3, ENSP000002795934MINT-8296785 MINT-8296796 MINT-8296809 I2D: score=6 STRING: ENSP00000279593
    PPM1FP495932, 3, ENSP000002632124MINT-8215492 I2D: score=1 STRING: ENSP00000263212
    CALM3P621583, ENSP000002912954I2D: score=2 STRING: ENSP00000291295
    CALM1P621583, ENSP000003494674I2D: score=2 STRING: ENSP00000349467
    CALM2P621583I2D: score=2 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle IEA--
    GO:0006468protein phosphorylation IDA17052756
    GO:0006816calcium ion transport IEA--
    GO:0007268synaptic transmission TAS--
    GO:0019221cytokine-mediated signaling pathway TAS--


    CAMK2A for ontologies           About GeneDecksing



    Drugs & Compounds
    for CAMK2A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CAMK2A for compounds           About GeneDecksing

    EMD Millipore small molecules for CAMK2A:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CAMK2A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    KN-62Non-competitive P2X7 antagonist[127191-97-3]
    KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
    Autocamtide-2-related inhibitory peptideSelective CaM kinase II inhibitor[167114-91-2]
    Arcyriaflavin APotent cdk4/cyclin D1 and CaM Kinase II inhibitor. Antiviral agent (anti-HCMV)[118458-54-1]

    3 HMDB Compounds for CAMK2A    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--

    3 DrugBank Compounds for CAMK2A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1,4-Dithiothreitol-- --target--17139284 17016423 10592235
    Hexatantalum Dodecabromide-- --target--17139284 17016423 10592235
    (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}-- --target--10592235

    5 Novoseek chemical compound relationships for CAMK2A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 32 7 15621017 (2), 18495661 (2), 19291219 (1), 8259515 (1)
    glutamate 29 3 8301355 (1), 8692993 (1), 1646294 (1)
    gaba 28.4 5 8301355 (2), 8692993 (1), 9153573 (1)
    glycogen 19.3 1 8639633 (1)
    atp 0 2 8391850 (1)

    Search CenterWatch for drugs/clinical trials and news about CAMK2A / KCC2A 

    Transcripts
    for CAMK2A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CAMK2A gene (2 alternative transcripts): 
    NM_015981.3  NM_171825.2  

    Unigene Cluster for CAMK2A:

    Calcium/calmodulin-dependent protein kinase II alpha
    Hs.743976  [show with all ESTs]
    Unigene Representative Sequence: NM_015981
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000348628(uc003lrt.2 uc003lru.2) ENST00000351010 ENST00000398376(uc010jhf.1)
    ENST00000508662(uc010jhe.2) ENST00000515758 ENST00000510347 ENST00000507995


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CAMK2A
    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate CAMK2A (see all 58):
    hsa-miR-21* hsa-miR-142-5p hsa-miR-25 hsa-miR-128 hsa-miR-578 hsa-miR-507 hsa-miR-4267 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmid: CAMK2A 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAMK2A (see all 7)
    OriGene shRNA RFP: CAMK2A
    OriGene siRNA: CAMK2A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CAMK2A
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMK2A 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAMK2A
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    Additional cDNA sequence: 

    AB023185.1 AF091486.1 AF145710.1 AF145711.1 AK289776.1 AK308853.1 AY429524.1 BC040457.1 
    BC114359.1 

    8 DOTS entries:

    DT.75101681  DT.92434464  DT.120799253  DT.120799251  DT.120799245  DT.92434462  DT.120799383  DT.95374686 

    24/101 AceView cDNA sequences (see all 101):

    NM_171825 CR612614 CR613519 AA410892 NM_015981 AA358854 AW899403 AW899421 
    AL119079 AY429524 AF091486 BE699884 BI599808 AI204919 AB023185 BI597390 
    BG699401 BX349890 BI545062 Z45619 BE699747 BQ184368 AW297106 BM805444 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CAMK2A (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:                                      -     -                                                                             -           -                     
    SP2:                                      -     -                                                                             -                                 
    SP3:                                                                                                                                                            
    SP4:        -     -                       -     -                                                                                                               
    SP5:                                      -     -     -                                                                                                         

    ExUns: 20 ^ 21
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for CAMK2A

    Expression
    for CAMK2A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CAMK2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGCGAATCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CAMK2A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartEndocardiumEndocardial Tube CellsEndocardium
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CAMK2A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CAMK2A

    SOURCE GeneReport for Unigene cluster: Hs.743976
        SABiosciences Expression via Pathway-Focused PCR Arrays including CAMK2A: 
              Circadian Rhythms in human mouse rat
              Neurotoxicity in human mouse rat
              Synaptic Plasticity in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CAMK2A
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMK2A

    Orthologs
    for CAMK2A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CAMK2A gene from 8/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Camk2a1 , 5 calcium/calmodulin-dependent protein kinase II alpha1, 5 93.03(n)1
    99.79(a)1    		   18 (34.41 cM)5
    123221  NM_177407.41  NP_803126.11 
     609256185 
    chicken
    (Gallus gallus)    		 Aves CAMK2A1 calcium/calmodulin-dependent protein kinase II alpha 86.61(n)
    97.75(a)    		   374175  NM_204295.1  NP_989626.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CAMK2A6
    		 --
    		 97(a)
    		 1 ↔ 1
    		 2(139082251-139262987)
    zebrafish
    (Danio rerio)    		 Actinopterygii camk2a1 calcium/calmodulin-dependent protein kinase (CaM kinase) more 81.02(n)
    94.33(a)    		   550436  NM_001017741.2  NP_001017741.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CaMKII3 learning and/or memory protein
    serine/threonine more    		 71(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea unc-436
    		 UNCoordinated family member (unc-43)
    		 49(a)
    		 1 → many
    		 IV(10324295-10350196)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons CPK291 calcium-dependent protein kinase 29 49.01(n)
    42.46(a)    		   843936  NM_202421.2  NP_974150.2 
    rice
    (Oryza sativa)    		 Liliopsida Os04g05606001 hypothetical protein 50.6(n)
    42.5(a)    		   4336653  NM_001060083.1  NP_001053548.1 


    ENSEMBL Gene Tree for CAMK2A (if available)
    TreeFam Gene Tree for CAMK2A (if available) 

    Paralogs
    for CAMK2A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CAMK2A gene
    PNCK2  CAMK1G2  PSKH22  DCX2  DCLK22  CAMK1D2  DCLK12  PSKH12  
    CAMK42  CAMK2D2  DCLK32  CAMKV2  CAMK2G2  CAMK2B2  CAMK12  
    18/58 SIMAP similar genes for CAMK2A using alignment to 8 protein entries:     KCC2A_HUMAN (see all proteins) (see all similar genes):
    CAMK2D    CAMK2B    CAMK2G    CASK    WNK1    MARK2
    WNK4    CDK4    MARK3    PNCK    DAPK3    DCLK3
    MKNK1    RPS6KA1    RPS6KA4    CAMK1D    CHEK1    TTN

    CAMK2A for paralogs           About GeneDecksing



    Genomic Variants
    for CAMK2A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1297 NCBI SNPs in CAMK2A are shown (see all 1297)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1126246141,2
    		C,--149598687(+) GGGTGG/AGGGAC 2 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1808989151,2
    		--149598690(+) TGGGGA/GACTTG 2 -- ds50010--------
    rs1859549991,2
    		--149598876(+) CAGGTA/GGGGCA 2 -- ds50010--------
    rs119507231,2
    		C,F,H,--149598893(+) CCAGGC/AATAAT 2 -- ds500110Minor allele frequency- A:0.03NS EA NA WA 1310
    rs1474306141,2
    		--149599068(+) GTTTGC/TAGCTA 2 -- ut310--------
    rs100436061,2
    		H--149599091(+) AAAACA/CCCAAG 2 -- ut314Minor allele frequency- C:0.00NS EA 420
    rs1149595061,2
    		--149599108(+) ACAAAC/TGCCCC 2 -- ut311Minor allele frequency- T:0.01NA 120
    rs1996587481,2
    		--149599127(+) TCCCA-/CCCCCGC 2 -- ut310--------
    rs1995179911,2
    		--149599129(+) CCCAC-/CCGCCCCC 2 -- ut310--------
    rs1381569871,2
    		C,--149599130(+) CCACC-/CGCCCCC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for CAMK2A (149599054 - 149669854 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CAMK2A: --

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    Disorders / Diseases
    for CAMK2A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CAMK2A for disorders           About GeneDecksing

    OMIM gene information: 114078    OMIM disorders: --

    16 diseases for CAMK2A:    About MalaCards
    brain ischemia    squamous cell carcinoma    ischemia    alzheimer's disease
    lung carcinoma    osteosarcoma    carcinoma    cerebritis
    neuroblastoma    retinitis    schizophrenia    tuberculosis
    pancreatitis    leukemia    neuronitis    breast cancer

    Human Genome Epidemiology (HuGE) Navigator: CAMK2A (3 documents)

    Export disorders for CAMK2A gene to outside databases

    Publications
    for CAMK2A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CAMK2A gene, integrated from 9 sources (see all 168):
    (articles sorted by number of sources associating them with CAMK2A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (1999)
    2. SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. (PubMed id 15312654)1, 2 Krapivinsky G.... Clapham D.E. (2004)
    3. Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase. (PubMed id 3475713)1, 3 Lin C.R....Rosenfeld M.G. (1987)
    4. The expression of calcium/calmodulin-dependent protein kinase II-alpha in the hippocampus of patients with Alzheimer's disease and its links with AD-related pathology. (PubMed id 15621017)1, 9 Wang Y.J....Liu R.Y. (2005)
    5. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    6. Substrate-selective and calcium-independent activation of CaMKII by a-actinin. (PubMed id 22427672)1 Jalan-Sakrikar N....Colbran R.J. (2012)
    7. AMPAR-independent effect of striatal aCaMKII promotes the sensitization of cocaine reward. (PubMed id 22573680)1 Kourrich S....Thomas M.J. (2012)
    8. The role of CaMKII in regulating GLUT4 expression in s keletal muscle. (PubMed id 22496345)1 Ojuka E.O....Smith J.A. (2012)
    9. Phosphorylation of Rpt6 regulates synaptic strength in hippocampal neurons. (PubMed id 22496558)1 Djakovic S.N....Patrick G.N. (2012)
    10. Attention deficit/hyperactivity disorder-derived codin g variation in the dopamine transporter disrupts microdomain targeting and traff icking regulation. (PubMed id 22514303)1 Sakrikar D....Blakely R.D. (2012)

    External Searches for CAMK2A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CAMK2A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 815 HGNC: 1460 AceView: CAMK2A Ensembl:ENSG00000070808 euGenes: HUgn815
    ECgene: CAMK2A Kegg: 815 H-InvDB: CAMK2A

    Other Databases showing CAMK2A gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0968

    Specialized Databases showing CAMK2A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CAMK2A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CAMK2A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CAMK2A gene:
    Search GeneIP for patents involving CAMK2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CAMK2A gene

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    About This Section

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