Aliases for CAMK2A Gene
- Calcium/Calmodulin Dependent Protein Kinase II Alpha 2 3 5
- Calcium/Calmodulin-Dependent Protein Kinase (CaM Kinase) II Alpha 2 3
- Calcium/Calmodulin-Dependent Protein Kinase Type II Alpha Chain 2 3
- Calcium/Calmodulin-Dependent Protein Kinase II Alpha-B Subunit 2 3
- CaM Kinase II Alpha Subunit 2 3
- CaM Kinase II Subunit Alpha 3 4
- CaM-Kinase II Alpha Chain 2 3
- CaMK-II Alpha Subunit 2 3
External Ids for CAMK2A Gene
Previous HGNC Symbols for CAMK2A Gene
Previous GeneCards Identifiers for CAMK2A Gene
The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]
GeneCards Summary for CAMK2A Gene
CAMK2A (Calcium/Calmodulin Dependent Protein Kinase II Alpha) is a Protein Coding gene. Diseases associated with CAMK2A include Conduct Disorder and Ischemia. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and MAPK Signaling: Oxidative Stress Pathway. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is CAMK2D.
UniProtKB/Swiss-Prot for CAMK2A Gene
CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity). Phosphorylates transcription factor FOXO3 on Ser-298 (PubMed:23805378). Activates FOXO3 transcriptional activity (By similarity).
Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through autoinhibition, which can be relieved by increases in Ca2+ levels.