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Aliases for CAMK2A Gene

Aliases for CAMK2A Gene

  • Calcium/Calmodulin-Dependent Protein Kinase II Alpha 2 3
  • CAMKA 3 4 6
  • Calcium/Calmodulin-Dependent Protein Kinase (CaM Kinase) II Alpha 2 3
  • Calcium/Calmodulin-Dependent Protein Kinase Type II Alpha Chain 2 3
  • Calcium/Calmodulin-Dependent Protein Kinase II Alpha-B Subunit 2 3
  • CaM Kinase II Alpha Subunit 2 3
  • CaM Kinase II Subunit Alpha 3 4
  • CaM-Kinase II Alpha Chain 2 3
  • CaMK-II Alpha Subunit 2 3
  • CaMK-II Subunit Alpha 3 4
  • EC 2.7.11.17 4 63
  • KIAA0968 4 6
  • Calcium/Calmodulin-Dependent Protein Kinase Type II Subunit Alpha 3
  • CaMKIINalpha 3
  • EC 2.7.11 63

External Ids for CAMK2A Gene

Previous HGNC Symbols for CAMK2A Gene

  • CAMKA

Previous GeneCards Identifiers for CAMK2A Gene

  • GC05M149669
  • GC05P150272
  • GC05M149582
  • GC05M149627
  • GC05M149579
  • GC05M144747

Summaries for CAMK2A Gene

Entrez Gene Summary for CAMK2A Gene

  • The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]

GeneCards Summary for CAMK2A Gene

CAMK2A (Calcium/Calmodulin-Dependent Protein Kinase II Alpha) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include calmodulin binding and calmodulin-dependent protein kinase activity. An important paralog of this gene is DCX.

UniProtKB/Swiss-Prot for CAMK2A Gene

  • CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).

Tocris Summary for CAMK2A Gene

  • Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through autoinhibition. Increases in Ca2+ levels allows calmodulin to relieve this autoinhibition and activate the kinase activity. There are two main classes of CaMKs; mulitfunctional CaMKs (CaMKK, CaMKI, CaMKII and CaMKIV) which have multiple downstream targets and substrate-specific CaMKs (CaMKIII) which have only one known downstream target. All CaMKs, with the exception of CaMKII, exist as monomers and most are expressed ubiquitously. Some subtypes display specific distributions, for example, CaMKIVbeta is expressed exclusively in cerebellar granule cells. CaMKs have numerous cellular functions and they influence processes as diverse as gene transcription, cell survival, apoptosis, cytoskeletal re-organization and learning and memory.

Gene Wiki entry for CAMK2A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMK2A Gene

Genomics for CAMK2A Gene

Regulatory Elements for CAMK2A Gene

Genomic Location for CAMK2A Gene

Start:
150,219,491 bp from pter
End:
150,290,291 bp from pter
Size:
70,801 bases
Orientation:
Minus strand

Genomic View for CAMK2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAMK2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMK2A Gene

Proteins for CAMK2A Gene

  • Protein details for CAMK2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQM7-KCC2A_HUMAN
    Recommended name:
    Calcium/calmodulin-dependent protein kinase type II subunit alpha
    Protein Accession:
    Q9UQM7
    Secondary Accessions:
    • Q9UL21
    • Q9Y2H4
    • Q9Y352

    Protein attributes for CAMK2A Gene

    Size:
    478 amino acids
    Molecular mass:
    54088 Da
    Quaternary structure:
    • CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with BAALC, MPDZ, SYN1, CAMK2N2 and SYNGAP1 (By similarity).
    SequenceCaution:
    • Sequence=BAA76812.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CAMK2A Gene

    Alternative splice isoforms for CAMK2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAMK2A Gene

Proteomics data for CAMK2A Gene at MOPED

Post-translational modifications for CAMK2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAMK2A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CAMK2A Gene

Graphical View of Domain Structure for InterPro Entry

Q9UQM7

UniProtKB/Swiss-Prot:

KCC2A_HUMAN :
  • Q9UQM7
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
genes like me logo Genes that share domains with CAMK2A: view

Function for CAMK2A Gene

Molecular function for CAMK2A Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state.
UniProtKB/Swiss-Prot Function: CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).

Enzyme Numbers (IUBMB) for CAMK2A Gene

Gene Ontology (GO) - Molecular Function for CAMK2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity ISS --
GO:0004683 calmodulin-dependent protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 17052756
genes like me logo Genes that share ontologies with CAMK2A: view
genes like me logo Genes that share phenotypes with CAMK2A: view

Animal Models for CAMK2A Gene

MGI Knock Outs for CAMK2A:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for CAMK2A Gene

Localization for CAMK2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMK2A Gene

Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse. Note=Postsynaptic lipid rafts. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAMK2A Gene COMPARTMENTS Subcellular localization image for CAMK2A gene
Compartment Confidence
cytosol 4
nucleus 4
plasma membrane 4
cytoskeleton 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CAMK2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005739 mitochondrion ISS --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with CAMK2A: view

Pathways for CAMK2A Gene

genes like me logo Genes that share pathways with CAMK2A: view

Gene Ontology (GO) - Biological Process for CAMK2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle ISS --
GO:0002931 response to ischemia ISS --
GO:0006468 protein phosphorylation IDA 17052756
GO:0006816 calcium ion transport ISS --
GO:0007268 synaptic transmission TAS --
genes like me logo Genes that share ontologies with CAMK2A: view

Compounds for CAMK2A Gene

(5) Tocris Compounds for CAMK2A Gene

Compound Action Cas Number
A 484954 CaM kinase III (eEF-2 kinase) inhibitor [142557-61-7]
Arcyriaflavin A Potent cdk4/cyclin D1 and CaM Kinase II inhibitor. Antiviral agent (anti-HCMV) [118458-54-1]
KN 93 CaM kinase II inhibitor; also K+ channel blocker (KV) [139298-40-1]
KN 93 phosphate CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278). [1188890-41-6]
STO-609 acetate Selective CaM kinase kinase inhibitor [1173022-21-3]

(3) HMDB Compounds for CAMK2A Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Calcium
  • Ca
7440-70-2

(3) Drugbank Compounds for CAMK2A Gene

(5) Novoseek inferred chemical compound relationships for CAMK2A Gene

Compound -log(P) Hits PubMed IDs
calcium 32 6
glutamate 29 3
gaba 28.4 4
glycogen 19.3 1
atp 0 1
genes like me logo Genes that share compounds with CAMK2A: view

Transcripts for CAMK2A Gene

Unigene Clusters for CAMK2A Gene

Calcium/calmodulin-dependent protein kinase II alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAMK2A Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - - -
SP2: - - -
SP3:
SP4: - - - -
SP5: - - -
SP6: -
SP7: -

ExUns: 20 ^ 21
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for CAMK2A Gene

GeneLoc Exon Structure for
CAMK2A
ECgene alternative splicing isoforms for
CAMK2A

Expression for CAMK2A Gene

mRNA expression in normal human tissues for CAMK2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAMK2A Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (11.0), Brain - Cortex (9.0), Brain - Anterior cingulate cortex (BA24) (8.9), Brain - Hippocampus (7.7), and Brain - Amygdala (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAMK2A Gene

SOURCE GeneReport for Unigene cluster for CAMK2A Gene Hs.743976

genes like me logo Genes that share expressions with CAMK2A: view

No data available for mRNA Expression by UniProt/SwissProt for CAMK2A Gene

Orthologs for CAMK2A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAMK2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAMK2A 35
  • 98.51 (n)
  • 98.29 (a)
CAMK2A 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CAMK2A 35
  • 93.93 (n)
  • 99.79 (a)
CAMK2A 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAMK2A 35
  • 92.91 (n)
  • 99.59 (a)
CAMK2A 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Camk2a 35
  • 93.03 (n)
  • 99.79 (a)
Camk2a 16
Camk2a 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CAMK2A 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAMK2A 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Camk2a 35
  • 93.38 (n)
  • 99.79 (a)
chicken
(Gallus gallus)
Aves CAMK2A 35
  • 86.61 (n)
  • 97.75 (a)
CAMK2A 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAMK2A 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia camk2a 35
  • 79.69 (n)
  • 96.52 (a)
zebrafish
(Danio rerio)
Actinopterygii camk2a 35
  • 81.02 (n)
  • 94.33 (a)
camk2a 36
  • 81 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CaMKII 36
  • 69 (a)
OneToMany
CaMKII 37
  • 71 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-43 36
  • 48 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os11g0136600 35
  • 49.95 (n)
  • 37.54 (a)
Species with no ortholog for CAMK2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAMK2A Gene

ENSEMBL:
Gene Tree for CAMK2A (if available)
TreeFam:
Gene Tree for CAMK2A (if available)

Paralogs for CAMK2A Gene

genes like me logo Genes that share paralogs with CAMK2A: view

Variants for CAMK2A Gene

Sequence variations from dbSNP and Humsavar for CAMK2A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs15645 -- 150,219,661(+) taaaa(A/C)aaaaC utr-variant-3-prime
rs869191 -- 150,245,836(+) GACAA(C/G)CAGAG intron-variant
rs869192 -- 150,246,048(+) CCATA(A/T)GCCGC intron-variant
rs873592 -- 150,290,193(-) TCATT(C/T)GTTCC upstream-variant-2KB
rs873593 -- 150,289,908(-) GTTTC(A/G/T)CAGTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CAMK2A Gene

Variant ID Type Subtype PubMed ID
nsv883030 CNV Loss 21882294
nsv524540 CNV Loss 19592680
esv2730912 CNV Deletion 23290073
esv2730913 CNV Deletion 23290073
esv2675470 CNV Deletion 23128226
nsv525244 CNV Loss 19592680

Relevant External Links for CAMK2A Gene

HapMap Linkage Disequilibrium report
CAMK2A
Human Gene Mutation Database (HGMD)
CAMK2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMK2A Gene

Disorders for CAMK2A Gene

Relevant External Links for CAMK2A

Genetic Association Database (GAD)
CAMK2A
Human Genome Epidemiology (HuGE) Navigator
CAMK2A
genes like me logo Genes that share disorders with CAMK2A: view

No data available for UniProtKB/Swiss-Prot for CAMK2A Gene

Publications for CAMK2A Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4
  2. Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase. (PMID: 3475713) Lin C.R. … Rosenfeld M.G. (Proc. Natl. Acad. Sci. U.S.A. 1987) 2 3
  3. SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. (PMID: 15312654) Krapivinsky G. … Clapham D.E. (Neuron 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. The expression of calcium/calmodulin-dependent protein kinase II-alpha in the hippocampus of patients with Alzheimer's disease and its links with AD-related pathology. (PMID: 15621017) Wang Y.J. … Liu R.Y. (Brain Res. 2005) 3 23

Products for CAMK2A Gene

Sources for CAMK2A Gene

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