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Aliases for CAMK2A Gene

Aliases for CAMK2A Gene

  • Calcium/Calmodulin Dependent Protein Kinase II Alpha 2 3
  • Calcium/Calmodulin-Dependent Protein Kinase (CaM Kinase) II Alpha 2 3
  • Calcium/Calmodulin-Dependent Protein Kinase Type II Alpha Chain 2 3
  • Calcium/Calmodulin-Dependent Protein Kinase II Alpha-B Subunit 2 3
  • Calcium/Calmodulin-Dependent Protein Kinase II Alpha 3 5
  • CaM Kinase II Alpha Subunit 2 3
  • CaM Kinase II Subunit Alpha 3 4
  • CaM-Kinase II Alpha Chain 2 3
  • CaMK-II Alpha Subunit 2 3
  • CaMK-II Subunit Alpha 3 4
  • EC 2.7.11.17 4 63
  • CAMKA 3 4
  • CaMKIINalpha 3
  • EC 2.7.11 63
  • KIAA0968 4

External Ids for CAMK2A Gene

Previous HGNC Symbols for CAMK2A Gene

  • CAMKA

Previous GeneCards Identifiers for CAMK2A Gene

  • GC05M149669
  • GC05P150272
  • GC05M149582
  • GC05M149627
  • GC05M149579
  • GC05M144747

Summaries for CAMK2A Gene

Entrez Gene Summary for CAMK2A Gene

  • The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]

GeneCards Summary for CAMK2A Gene

CAMK2A (Calcium/Calmodulin Dependent Protein Kinase II Alpha) is a Protein Coding gene. Diseases associated with CAMK2A include conduct disorder and autosomal recessive non-syndromic intellectual disability. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is CAMK2D.

UniProtKB/Swiss-Prot for CAMK2A Gene

  • CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).

Tocris Summary for CAMK2A Gene

  • Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through autoinhibition, which can be relieved by increases in Ca2+ levels.

Gene Wiki entry for CAMK2A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMK2A Gene

Genomics for CAMK2A Gene

Regulatory Elements for CAMK2A Gene

Genomic Location for CAMK2A Gene

Chromosome:
5
Start:
150,219,491 bp from pter
End:
150,290,291 bp from pter
Size:
70,801 bases
Orientation:
Minus strand

Genomic View for CAMK2A Gene

Genes around CAMK2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAMK2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAMK2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMK2A Gene

Proteins for CAMK2A Gene

  • Protein details for CAMK2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQM7-KCC2A_HUMAN
    Recommended name:
    Calcium/calmodulin-dependent protein kinase type II subunit alpha
    Protein Accession:
    Q9UQM7
    Secondary Accessions:
    • Q9UL21
    • Q9Y2H4
    • Q9Y352

    Protein attributes for CAMK2A Gene

    Size:
    478 amino acids
    Molecular mass:
    54088 Da
    Quaternary structure:
    • CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with BAALC, MPDZ, SYN1, CAMK2N2 and SYNGAP1 (By similarity).
    SequenceCaution:
    • Sequence=BAA76812.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CAMK2A Gene

    Alternative splice isoforms for CAMK2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAMK2A Gene

Proteomics data for CAMK2A Gene at MOPED

Post-translational modifications for CAMK2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAMK2A Gene

Antibody Products

  • R&D Systems Antibodies for CAMK2A (CaM Kinase II alpha)
  • Cell Signaling Technology (CST) Antibodies for CAMK2A (CAMK2A)

Domains & Families for CAMK2A Gene

Graphical View of Domain Structure for InterPro Entry

Q9UQM7

UniProtKB/Swiss-Prot:

KCC2A_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
genes like me logo Genes that share domains with CAMK2A: view

Function for CAMK2A Gene

Molecular function for CAMK2A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state.
UniProtKB/Swiss-Prot Function:
CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).

Enzyme Numbers (IUBMB) for CAMK2A Gene

Gene Ontology (GO) - Molecular Function for CAMK2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004683 calmodulin-dependent protein kinase activity IEA --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
genes like me logo Genes that share ontologies with CAMK2A: view
genes like me logo Genes that share phenotypes with CAMK2A: view

Animal Models for CAMK2A Gene

MGI Knock Outs for CAMK2A:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAMK2A Gene

Localization for CAMK2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMK2A Gene

Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse. Note=Postsynaptic lipid rafts. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAMK2A Gene COMPARTMENTS Subcellular localization image for CAMK2A gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 5
mitochondrion 4
cytoskeleton 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for CAMK2A Gene

Pathways & Interactions for CAMK2A Gene

SuperPathways for CAMK2A Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Post NMDA receptor activation events
3 Development Angiotensin activation of ERK
4 Development Endothelin-1/EDNRA signaling
5 Cardiac conduction
genes like me logo Genes that share pathways with CAMK2A: view

SIGNOR curated interactions for CAMK2A Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CAMK2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle ISS --
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0002931 response to ischemia IEA,ISS --
GO:0006468 protein phosphorylation IEA,IDA 17052756
genes like me logo Genes that share ontologies with CAMK2A: view

Drugs & Compounds for CAMK2A Gene

(6) Drugs for CAMK2A Gene - From: Novoseek, DrugBank, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME} Experimental Pharma Target 0
1,4-Dithiothreitol Experimental Pharma Target 0
Hexatantalum Dodecabromide Experimental Pharma Target 0
KN-62 Pharma CaM kinase II inhibitor, Non-competitive P2X7 antagonist 0

(7) Additional Compounds for CAMK2A Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arcyriaflavin A
118458-54-1
Autocamtide-2-related inhibitory peptide
167114-91-2
KN 93
139298-40-1
STO-609 acetate
1173022-21-3

(5) Tocris Compounds for CAMK2A Gene

Compound Action Cas Number
Arcyriaflavin A Potent cdk4/cyclin D1 and CaM Kinase II inhibitor. Antiviral agent (anti-HCMV) 118458-54-1
Autocamtide-2-related inhibitory peptide Selective CaM kinase II inhibitor 167114-91-2
KN 93 CaM kinase II inhibitor; also K+ channel blocker (KV) 139298-40-1
KN-62 Non-competitive P2X7 antagonist 127191-97-3
STO-609 acetate Selective CaM kinase kinase inhibitor 1173022-21-3
genes like me logo Genes that share compounds with CAMK2A: view

Transcripts for CAMK2A Gene

Unigene Clusters for CAMK2A Gene

Calcium/calmodulin-dependent protein kinase II alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAMK2A Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - - -
SP2: - - -
SP3:
SP4: - - - -
SP5: - - -
SP6: -
SP7: -

ExUns: 20 ^ 21
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for CAMK2A Gene

GeneLoc Exon Structure for
CAMK2A
ECgene alternative splicing isoforms for
CAMK2A

Expression for CAMK2A Gene

mRNA expression in normal human tissues for CAMK2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAMK2A Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x11.0), Brain - Cortex (x9.0), Brain - Anterior cingulate cortex (BA24) (x8.9), Brain - Hippocampus (x7.7), and Brain - Amygdala (x6.0).

Protein differential expression in normal tissues from HIPED for CAMK2A Gene

This gene is overexpressed in Brain (37.5) and Frontal cortex (26.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAMK2A Gene



SOURCE GeneReport for Unigene cluster for CAMK2A Gene Hs.743976

genes like me logo Genes that share expression patterns with CAMK2A: view

Protein tissue co-expression partners for CAMK2A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CAMK2A Gene

Orthologs for CAMK2A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAMK2A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CAMK2A 35
  • 93.93 (n)
  • 99.79 (a)
CAMK2A 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAMK2A 35
  • 92.91 (n)
  • 99.59 (a)
CAMK2A 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Camk2a 35
  • 93.03 (n)
  • 99.79 (a)
Camk2a 16
Camk2a 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CAMK2A 35
  • 98.51 (n)
  • 98.29 (a)
CAMK2A 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Camk2a 35
  • 93.38 (n)
  • 99.79 (a)
oppossum
(Monodelphis domestica)
Mammalia CAMK2A 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAMK2A 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves CAMK2A 35
  • 86.61 (n)
  • 97.75 (a)
CAMK2A 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAMK2A 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia camk2a 35
  • 79.69 (n)
  • 96.52 (a)
zebrafish
(Danio rerio)
Actinopterygii camk2a 35
  • 81.02 (n)
  • 94.33 (a)
camk2a 36
  • 81 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CaMKII 37
  • 71 (a)
CaMKII 36
  • 69 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-43 36
  • 48 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os11g0136600 35
  • 49.95 (n)
  • 37.54 (a)
Species with no ortholog for CAMK2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAMK2A Gene

ENSEMBL:
Gene Tree for CAMK2A (if available)
TreeFam:
Gene Tree for CAMK2A (if available)

Paralogs for CAMK2A Gene

genes like me logo Genes that share paralogs with CAMK2A: view

Variants for CAMK2A Gene

Sequence variations from dbSNP and Humsavar for CAMK2A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs15645 -- 150,219,661(+) taaaa(A/C)aaaaC utr-variant-3-prime
rs919740 -- 150,286,286(-) TTCCA(C/T)TGAAG intron-variant
rs919741 -- 150,232,125(-) GAGAG(A/G)TGGTG intron-variant
rs930211 -- 150,246,984(-) GGGGA(A/G)CGCAG intron-variant
rs930212 -- 150,246,983(-) GGGAG(A/C)GCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAMK2A Gene

Variant ID Type Subtype PubMed ID
nsv883030 CNV Loss 21882294
nsv524540 CNV Loss 19592680
esv2730912 CNV Deletion 23290073
esv2730913 CNV Deletion 23290073
esv2675470 CNV Deletion 23128226
nsv525244 CNV Loss 19592680

Variation tolerance for CAMK2A Gene

Residual Variation Intolerance Score: 15.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.06; 1.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAMK2A Gene

HapMap Linkage Disequilibrium report
CAMK2A
Human Gene Mutation Database (HGMD)
CAMK2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMK2A Gene

Disorders for CAMK2A Gene

MalaCards: The human disease database

(2) MalaCards diseases for CAMK2A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
conduct disorder
autosomal recessive non-syndromic intellectual disability
  • autosomal recessive mental retardation
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CAMK2A

Genetic Association Database (GAD)
CAMK2A
Human Genome Epidemiology (HuGE) Navigator
CAMK2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAMK2A
genes like me logo Genes that share disorders with CAMK2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CAMK2A Gene

Publications for CAMK2A Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 67
  2. The expression of calcium/calmodulin-dependent protein kinase II-alpha in the hippocampus of patients with Alzheimer's disease and its links with AD-related pathology. (PMID: 15621017) Wang Y.J. … Liu R.Y. (Brain Res. 2005) 3 23
  3. Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase. (PMID: 3475713) Lin C.R. … Rosenfeld M.G. (Proc. Natl. Acad. Sci. U.S.A. 1987) 2 3
  4. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for CAMK2A Gene

Sources for CAMK2A Gene

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