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CAMK1G Gene

protein-coding   GIFtS: 63
GCID: GC01P209757

Calcium/Calmodulin-Dependent Protein Kinase IG

  See CAMK1G-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calcium/Calmodulin-Dependent Protein Kinase IG1 2     CLICK III2 3
CLICK32 3 5     EC 2.7.11.173 8
CaM Kinase I Gamma2 3     CLICKIII2
CaM Kinase IG2 3     caMKIG2
CaM-KI Gamma2 3     Calcium/Calmodulin-Dependent Protein Kinase Type 1G2
CaMK-Like CREB Kinase III2 3     dJ272L16.12
CaMKI Gamma2 3     CaMKIG3
VWS12 3     EC 2.7.118

External Ids:    HGNC: 145851   Entrez Gene: 571722   Ensembl: ENSG000000081187   OMIM: 6149945   UniProtKB: Q96NX53   

Export aliases for CAMK1G gene to outside databases

Previous GC identifers: GC01P208396 GC01P205462 GC01P206396 GC01P206836 GC01P206145 GC01P207823 GC01P180432


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CAMK1G Gene:
This gene encodes a protein similar to calcium/calmodulin dependent protein kinase, however, its exact function is
not known. (provided by RefSeq, Jul 2008)

GeneCards Summary for CAMK1G Gene:
CAMK1G (calcium/calmodulin-dependent protein kinase IG) is a protein-coding gene. Diseases associated with CAMK1G include van der woude syndrome. GO annotations related to this gene include calmodulin binding and calmodulin-dependent protein kinase activity. An important paralog of this gene is PNCK.

UniProtKB/Swiss-Prot: KCC1G_HUMAN, Q96NX5
Function: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade.
In vitro phosphorylates transcription factor CREB1 (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CAMK1G gene promoter:
         Max1   ISGF-3   AML1a   Tal-1beta   MZF-1   CP2   deltaCREB   COMP1   c-Myb   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCAMK1G promoter sequence
   Search Chromatin IP Primers for CAMK1G

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CAMK1G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.2   Ensembl cytogenetic band:  1q32.2   HGNC cytogenetic band: 1q32.2

CAMK1G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAMK1G gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P209757:  view genomic region     (about GC identifiers)

Start:
209,757,045 bp from pter      End:
209,787,284 bp from pter
Size:
30,240 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KCC1G_HUMAN, Q96NX5 (See protein sequence)
Recommended Name: Calcium/calmodulin-dependent protein kinase type 1G  
Size: 476 amino acids; 53087 Da
Sequence caution: Sequence=CAB41259.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for CAMK1G:
2JAM (3D)    
Secondary accessions: Q86UH5 Q9Y3J7
Alternative splicing: 2 isoforms:  Q96NX5-1   Q96NX5-2   

Explore the universe of human proteins at neXtProt for CAMK1G: NX_Q96NX5

Explore proteomics data for CAMK1G at MOPED

Post-translational modifications: 

  • May be prenylated on Cys-473 (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CAMK1G (Q96NX5) (see all 12)
     GGELFDR  ENEIAVL  YVAPEVL  QIQKNFA 


    See CAMK1G Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065172.1  
    ENSEMBL proteins: 
     ENSP00000009105   ENSP00000392173   ENSP00000354861  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: calcium/calmodulin-dependent protein kinase IG
    CAMK1 family

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q96NX5

    ProtoNet protein and cluster: Q96NX5

    UniProtKB/Swiss-Prot: KCC1G_HUMAN, Q96NX5
    Domain: The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded
    state with the catalytic domain as a pseudosubstrate (By similarity)
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with CAMK1G           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCC1G_HUMAN, Q96NX5
    Function: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade.
    In vitro phosphorylates transcription factor CREB1 (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by Ca(2+)/calmodulin. Binding of calmodulin is thought to result in a conformational
    change and leads to activation through phosphorylation by CAMKK1 (By similarity)

         Genatlas biochemistry entry for CAMK1G:
    rat calcium/calmodulin dependent protein kinase 1,gamma homolog

         Enzyme Numbers (IUBMB): EC 2.7.11.171 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004683calmodulin-dependent protein kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005516calmodulin binding IEA--
         
    Find genes that share ontologies with CAMK1G           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CAMK1G:
     Decreased substrate adherent c  Increased apoptosis 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Camk1g):
     nervous system 

    Find genes that share phenotypes with CAMK1G           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CAMK1G
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAMK1G
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    hsa-miR-4254 hsa-miR-3194-5p hsa-miR-769-5p hsa-miR-631 hsa-miR-4306 hsa-miR-3661 hsa-miR-3647-3p hsa-miR-135b
    SwitchGear 3'UTR luciferase reporter plasmidCAMK1G 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KCC1G_HUMAN, Q96NX5: Cytoplasm (By similarity). Golgi apparatus membrane; Peripheral membrane protein (By
    similarity). Cell membrane; Peripheral membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    plasma membrane5
    cytosol3
    nucleus2
    endoplasmic reticulum1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane IEA--
    GO:0005954calcium- and calmodulin-dependent protein kinase complex IEA--
    GO:0012505endomembrane system ----

    Find genes that share ontologies with CAMK1G           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CAMK1G About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    cAMP Pathway0.77
    2NFAT and Cardiac Hypertrophy
    NFAT and Cardiac Hypertrophy0.42
    IGF1R Signaling0.37
    3GPCR Pathway
    Breast Cancer Regulation by Stathmin10.58
    4ErbB signaling pathway
    EGFR Inhibitor Pathway, Pharmacodynamics0.49
    5Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47


    Find genes that share SuperPaths with CAMK1G           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CAMK1G (see all 8)
        Breast Cancer Regulation by Stathmin1
    Neuropathic Pain-Signaling in Dorsal Horn Neurons
    IGF1R Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA

    1 Sino Biological Pathway for CAMK1G
        EGFR Signaling Pathway

    1 PharmGKB Pathway for CAMK1G
        EGFR Inhibitor Pathway, Pharmacodynamics

    1 Kegg Pathway  (Kegg details for CAMK1G):
        Oxytocin signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CAMK1G
    Interactions:

        Search GeneGlobe Interaction Network for CAMK1G

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for CAMK1G (Q96NX53 ENSP000000091054) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARRB2P321213I2D: score=1 
    CAMK1DENSP000003681244STRING: ENSP00000368124
    CAMK2BENSP000002586824STRING: ENSP00000258682
    CAMK2DENSP000003397404STRING: ENSP00000339740
    CAMK2GENSP000003190604STRING: ENSP00000319060
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----

    Find genes that share ontologies with CAMK1G           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CAMK1G (KCC1G)

    3 HMDB Compounds for CAMK1G    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for CAMK1G    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    5-[(E)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-[2-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CAMK1G gene: 
    NM_020439.2  

    Unigene Cluster for CAMK1G:

    Calcium/calmodulin-dependent protein kinase IG
    Hs.199068  [show with all ESTs]
    Unigene Representative Sequence: AK095713
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000009105(uc001hhf.4 uc001hhd.3 uc001hhe.3) ENST00000423146
    ENST00000361322 ENST00000494990
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    hsa-miR-4254 hsa-miR-3194-5p hsa-miR-769-5p hsa-miR-631 hsa-miR-4306 hsa-miR-3661 hsa-miR-3647-3p hsa-miR-135b
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    Additional mRNA sequence: 

    AF428261.1 AK095713.1 AK289675.1 AL049688.1 AY212935.1 BC032787.1 

    6 DOTS entries:

    DT.40231309  DT.100018751  DT.97784123  DT.100749520  DT.121437584  DT.91965199 

    Selected AceView cDNA sequences (see all 32):

    BU149661 BC032787 BG170935 AL049688 CB154014 BI821474 BI824483 BM547443 
    NM_020439 AY212935 BX493511 BI834635 BM807335 CK822988 AW016039 CK822987 
    BI772626 BQ102407 BG715920 BQ086330 AL134342 BI818261 AF428261 BI084897 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CAMK1G (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ·
    SP1:                                      -                       -           -                       -                 -                                       
    SP2:              -                       -                       -           -                       -                 -                                       
    SP3:                                      -                       -           -                       -                 -                                       
    SP4:              -                       -                       -           -                       -     -           -                                       
    SP5:              -                       -                                   -                                                                                 

    ExUns: 11d ^ 12 ^ 13
    SP1:  -               
    SP2:  -               
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for CAMK1G

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CAMK1G expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCAGTGTTG
    CAMK1G Expression
    About this image


    CAMK1G expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebellum
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    CAMK1G Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CAMK1G Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.199068

    UniProtKB/Swiss-Prot: KCC1G_HUMAN, Q96NX5
    Tissue specificity: Mainly expressed in brain with small amounts in skeletal muscles, kidney, spleen and liver.
    Strongly expressed in forebrain neocortex, striatum and limbic system

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMK1G

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CAMK1G gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Camk1g1 , 5 calcium/calmodulin-dependent protein kinase I gamma1, 5 87.89(n)1
    92.23(a)1
      1 (97.74 cM)5
    2153031  NM_144817.21  NP_659066.11 
     1933463465 
    chicken
    (Gallus gallus)
    Aves CAMK1G1 calcium/calmodulin-dependent protein kinase IG 74.02(n)
    79.69(a)
      419859  XM_004934980.1  XP_004935037.1 
    lizard
    (Anolis carolinensis)
    Reptilia CAMK1G6
    calcium/calmodulin-dependent protein kinase IG
    65(a)
    1 ↔ 1
    4(125834990-125893150)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia camk1g1 calcium/calmodulin-dependent protein kinase IG 70.76(n)
    77.44(a)
      100494644  XM_002933536.2  XP_002933582.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc731552 hypothetical protein MGC73155 75.74(n)   393802  BC060911.1 


    ENSEMBL Gene Tree for CAMK1G (if available)
    TreeFam Gene Tree for CAMK1G (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CAMK1G gene
    PNCK2  PSKH22  DCX2  DCLK22  CAMK2A2  CAMK1D2  DCLK12  PSKH12  
    CAMK42  CAMK2D2  DCLK32  CAMKV2  CAMK2G2  CAMK2B2  CAMK12  
    Selected SIMAP similar genes for CAMK1G using alignment to 2 protein entries:     KCC1G_HUMAN (see all proteins) (see all similar genes):
    CAMK1D    CAMK1    PNCK    BRSK2    PSKH2    NUAK1
    PSKH1    RPS6KA4    DCLK3    PRKAA2    PRKAA1    MYLK
    CAMK4    CHEK2    RPS6KA5    RPS6KA1    MARK2    MARK1

    Find genes that share paralogs with CAMK1G           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CAMK1G (see all 789)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0406014
    A breast infiltrating ductal carcinoma sample4--see VAR_0406012 A T mis40--------
    rs741579801,2
    C--209755157(+) AATTCG/ATAGAA 1 -- us2k14Minor allele frequency- A:0.10WA NA EA 360
    rs1827418481,2
    --209755185(+) TCCCCA/GTATAG 1 -- us2k10--------
    rs557093811,2
    C,F--209755202(+) GGGCAG/ATGCAG 1 -- us2k14Minor allele frequency- A:0.14CSA WA NA EA 359
    rs1116136991,2
    F--209755230(+) TATAAG/AGGCAC 1 -- us2k12Minor allele frequency- A:0.04CSA WA 120
    rs1873725181,2
    --209755245(+) TCCATC/TCACAA 1 -- us2k10--------
    rs1436765741,2
    C--209755273(+) CTTCAC/TCACCT 1 -- us2k10--------
    rs1481122461,2
    C--209755316(+) TGGTGA/GTTAGC 1 -- us2k10--------
    rs1418668411,2
    --209755364(+) AGACTA/GTGGCA 1 -- us2k10--------
    rs561654131,2
    C,F--209755450(+) GTCTCG/ACTCCA 1 -- us2k15Minor allele frequency- A:0.14NA CSA WA EA 361

    HapMap Linkage Disequilibrium report for CAMK1G (209757045 - 209787284 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CAMK1G:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672471CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CAMK1G
    DNA2.0 Custom Variant and Variant Library Synthesis for CAMK1G

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614994    OMIM disorders: --

    1 disease for CAMK1G:    
    About MalaCards
    van der woude syndrome


    Find genes that share disorders with CAMK1G           About GenesLikeMe

    Genetic Association Database (GAD): CAMK1G
    Human Genome Epidemiology (HuGE) Navigator: CAMK1G (3 documents)

    Export disorders for CAMK1G gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CAMK1G gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with CAMK1G)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of CLICK-III/CaMKIgamma, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK). (PubMed id 12637513)1, 2, 3 Takemoto-Kimura S.... Bito H. (J. Biol. Chem. 2003)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. A preliminary gene map for the Van der Woude syndrome critical region derived from 900 kb of genomic sequence at 1q32-q41. (PubMed id 10645953)1, 2 Schutte B.C.... Murray J.C. (Genome Res. 2000)
    6. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    7. Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis. (PubMed id 23624525)1 Deng M....Zhang X. (Nat. Genet. 2013)
    8. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    9. Functional genomics identifies therapeutic targets for MYC-driven cancer. (PubMed id 22623531)1 Toyoshima M....Grandori C. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57172 HGNC: 14585 AceView: CAMK1G Ensembl:ENSG00000008118 euGenes: HUgn57172
    ECgene: CAMK1G Kegg: 57172 H-InvDB: CAMK1G

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CAMK1G Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CAMK1G gene:
    Search GeneIP for patents involving CAMK1G

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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