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Aliases for CAMK1G Gene

Aliases for CAMK1G Gene

  • Calcium/Calmodulin-Dependent Protein Kinase IG 2 3
  • CLICK3 3 4 6
  • CaMK-Like CREB Kinase III 3 4
  • CaM Kinase I Gamma 3 4
  • CaM Kinase IG 3 4
  • CaM-KI Gamma 3 4
  • EC 4 63
  • CaMKI Gamma 3 4
  • CLICK III 3 4
  • CaMKIG 3 4
  • VWS1 3 4
  • Calcium/Calmodulin-Dependent Protein Kinase Type 1G 3
  • DJ272L16.1 3
  • EC 2.7.11 63

External Ids for CAMK1G Gene

Previous GeneCards Identifiers for CAMK1G Gene

  • GC01P208396
  • GC01P205462
  • GC01P206396
  • GC01P206836
  • GC01P206145
  • GC01P207823
  • GC01P209757
  • GC01P180432

Summaries for CAMK1G Gene

Entrez Gene Summary for CAMK1G Gene

  • This gene encodes a protein similar to calcium/calmodulin dependent protein kinase, however, its exact function is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAMK1G Gene

CAMK1G (Calcium/Calmodulin-Dependent Protein Kinase IG) is a Protein Coding gene. Diseases associated with CAMK1G include van der woude syndrome. Among its related pathways are GPCR Pathway and Activation of cAMP-Dependent PKA. GO annotations related to this gene include calmodulin binding and calmodulin-dependent protein kinase activity. An important paralog of this gene is DCX.

UniProtKB/Swiss-Prot for CAMK1G Gene

  • Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMK1G Gene

Genomics for CAMK1G Gene

Regulatory Elements for CAMK1G Gene

Genomic Location for CAMK1G Gene

209,583,700 bp from pter
209,613,939 bp from pter
30,240 bases
Plus strand

Genomic View for CAMK1G Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAMK1G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMK1G Gene

Proteins for CAMK1G Gene

  • Protein details for CAMK1G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcium/calmodulin-dependent protein kinase type 1G
    Protein Accession:
    Secondary Accessions:
    • Q86UH5
    • Q9Y3J7

    Protein attributes for CAMK1G Gene

    476 amino acids
    Molecular mass:
    53087 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAB41259.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CAMK1G Gene

    Alternative splice isoforms for CAMK1G Gene


neXtProt entry for CAMK1G Gene

Proteomics data for CAMK1G Gene at MOPED

Post-translational modifications for CAMK1G Gene

Other Protein References for CAMK1G Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Protein Products

Domains for CAMK1G Gene

Gene Families for CAMK1G Gene

Suggested Antigen Peptide Sequences for CAMK1G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96NX5
  • The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
genes like me logo Genes that share domains with CAMK1G: view

Function for CAMK1G Gene

Molecular function for CAMK1G Gene

GENATLAS Biochemistry:
rat calcium/calmodulin dependent protein kinase 1,gamma homolog
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by Ca(2+)/calmodulin. Binding of calmodulin is thought to result in a conformational change and leads to activation through phosphorylation by CAMKK1 (By similarity).
UniProtKB/Swiss-Prot Function:
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1 (By similarity).

Enzyme Numbers (IUBMB) for CAMK1G Gene

Gene Ontology (GO) - Molecular Function for CAMK1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity --
GO:0004683 calmodulin-dependent protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005516 calmodulin binding IEA --
genes like me logo Genes that share ontologies with CAMK1G: view

Phenotypes for CAMK1G Gene

MGI mutant phenotypes for CAMK1G:
inferred from 1 alleles
GenomeRNAi human phenotypes for CAMK1G:
genes like me logo Genes that share phenotypes with CAMK1G: view

Animal Model Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CAMK1G Gene

Localization for CAMK1G Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMK1G Gene

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for CAMK1G Gene COMPARTMENTS Subcellular localization image for CAMK1G gene
Compartment Confidence
golgi apparatus 5
plasma membrane 5
cytosol 3
nucleus 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CAMK1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm --
GO:0005794 Golgi apparatus --
GO:0005886 plasma membrane IEA --
GO:0005954 calcium- and calmodulin-dependent protein kinase complex IEA --
genes like me logo Genes that share ontologies with CAMK1G: view

Pathways for CAMK1G Gene

genes like me logo Genes that share pathways with CAMK1G: view

Pathways by source for CAMK1G Gene

1 PharmGKB pathway for CAMK1G Gene
1 KEGG pathway for CAMK1G Gene

Interacting Proteins for CAMK1G Gene

Gene Ontology (GO) - Biological Process for CAMK1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with CAMK1G: view

Compounds for CAMK1G Gene

(3) HMDB Compounds for CAMK1G Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
  • Ca

(1) Drugbank Compounds for CAMK1G Gene

genes like me logo Genes that share compounds with CAMK1G: view

Transcripts for CAMK1G Gene

Unigene Clusters for CAMK1G Gene

Calcium/calmodulin-dependent protein kinase IG:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CAMK1G

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CAMK1G Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ·
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - -
SP6: - - - - -
SP7: -
SP8: - - - -
SP9: -

ExUns: 11d ^ 12 ^ 13
SP1: -
SP2: -

Relevant External Links for CAMK1G Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CAMK1G Gene

mRNA expression in normal human tissues for CAMK1G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAMK1G Gene

This gene is overexpressed in Brain - Cortex (8.6), Brain - Frontal Cortex (BA9) (7.0), Brain - Nucleus accumbens (basal ganglia) (6.6), Brain - Anterior cingulate cortex (BA24) (6.0), and Brain - Putamen (basal ganglia) (4.8).

Protein differential expression in normal tissues for CAMK1G Gene

This gene is overexpressed in Liver (63.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CAMK1G Gene

SOURCE GeneReport for Unigene cluster for CAMK1G Gene Hs.199068

mRNA Expression by UniProt/SwissProt for CAMK1G Gene

Tissue specificity: Mainly expressed in brain with small amounts in skeletal muscles, kidney, spleen and liver. Strongly expressed in forebrain neocortex, striatum and limbic system.
genes like me logo Genes that share expressions with CAMK1G: view

Expression partners for CAMK1G Gene

In Situ Assay Products

Orthologs for CAMK1G Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CAMK1G Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CAMK1G 35
  • 90.35 (n)
  • 92.81 (a)
  • 92 (a)
(Canis familiaris)
Mammalia CAMK1G 35
  • 91.11 (n)
  • 94.12 (a)
  • 94 (a)
(Mus musculus)
Mammalia Camk1g 35
  • 87.89 (n)
  • 92.23 (a)
Camk1g 16
Camk1g 36
  • 92 (a)
(Pan troglodytes)
Mammalia CAMK1G 35
  • 99.51 (n)
  • 99.79 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Camk1g 35
  • 87.39 (n)
  • 92.65 (a)
(Monodelphis domestica)
Mammalia CAMK1G 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia CAMK1G 36
  • 81 (a)
(Gallus gallus)
Aves CAMK1G 35
  • 74.02 (n)
  • 79.69 (a)
  • 77 (a)
(Anolis carolinensis)
Reptilia CAMK1G 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia camk1g 35
  • 70.76 (n)
  • 77.44 (a)
(Danio rerio)
Actinopterygii camk1gb 35
  • 65.5 (n)
  • 65.35 (a)
zgc73155 35
camk1ga 36
  • 58 (a)
camk1gb 36
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CaMKI 37
  • 57 (a)
(Caenorhabditis elegans)
Secernentea cmk-1 37
  • 57 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMK2 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
Species with no ortholog for CAMK1G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAMK1G Gene

Gene Tree for CAMK1G (if available)
Gene Tree for CAMK1G (if available)

Paralogs for CAMK1G Gene

genes like me logo Genes that share paralogs with CAMK1G: view

Variants for CAMK1G Gene

Sequence variations from dbSNP and Humsavar for CAMK1G Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs713073 -- 209,590,745(-) CCCCA(C/T)CCTTG intron-variant
rs713074 -- 209,590,628(-) TCTTC(C/T)GGAGC intron-variant
rs713075 -- 209,590,905(-) ATCAG(G/T)TTTAA intron-variant
rs742253 -- 209,585,700(+) AAAAA(A/G)CATCC intron-variant
rs760832 -- 209,607,403(+) CCTAA(C/T)CTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAMK1G Gene

Variant ID Type Subtype PubMed ID
esv2672471 CNV Deletion 23128226

Relevant External Links for CAMK1G Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMK1G Gene

Disorders for CAMK1G Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CAMK1G Gene in MalaCards »

(1) Diseases for CAMK1G Gene including...

Relevant External Links for CAMK1G

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CAMK1G: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CAMK1G Gene

Publications for CAMK1G Gene

  1. Molecular cloning and characterization of CLICK-III/CaMKIgamma, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK). (PMID: 12637513) Takemoto-Kimura S. … Bito H. (J. Biol. Chem. 2003) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. A preliminary gene map for the Van der Woude syndrome critical region derived from 900 kb of genomic sequence at 1q32-q41. (PMID: 10645953) Schutte B.C. … Murray J.C. (Genome Res. 2000) 3 4
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48

Products for CAMK1G Gene

Sources for CAMK1G Gene

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