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Aliases for CAMK1D Gene

Aliases for CAMK1D Gene

  • Calcium/Calmodulin Dependent Protein Kinase ID 2 3 5
  • Calcium/Calmodulin-Dependent Protein Kinase ID 2 3
  • CaM Kinase I Delta 3 4
  • CaM Kinase ID 3 4
  • CaM-KI Delta 3 4
  • EC 2.7.11.17 4 63
  • CaMKI Delta 3 4
  • CaMKID 3 4
  • CKLiK 3 4
  • CamKI-Like Protein Kinase 3
  • CaMKI-Like Protein Kinase 4
  • EC 2.7.11 63
  • CaM-K1 3

External Ids for CAMK1D Gene

Previous GeneCards Identifiers for CAMK1D Gene

  • GC10P012395
  • GC10P012431

Summaries for CAMK1D Gene

Entrez Gene Summary for CAMK1D Gene

  • This gene is a member of the calcium/calmodulin-dependent protein kinase 1 family, a subfamily of the serine/threonine kinases. The encoded protein is a component of the calcium-regulated calmodulin-dependent protein kinase cascade. It has been associated with multiple processes including regulation of granulocyte function, activation of CREB-dependent gene transcription, aldosterone synthesis, differentiation and activation of neutrophil cells, and apoptosis of erythroleukemia cells. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jan 2015]

GeneCards Summary for CAMK1D Gene

CAMK1D (Calcium/Calmodulin Dependent Protein Kinase ID) is a Protein Coding gene. Among its related pathways are EGFR Signaling Pathway and Neuroscience. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CAMK2D.

UniProtKB/Swiss-Prot for CAMK1D Gene

  • Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMK1D Gene

Genomics for CAMK1D Gene

Regulatory Elements for CAMK1D Gene

Enhancers for CAMK1D Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CAMK1D on UCSC Golden Path with GeneCards custom track

Promoters for CAMK1D Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CAMK1D on UCSC Golden Path with GeneCards custom track

Genomic Location for CAMK1D Gene

Chromosome:
10
Start:
12,349,482 bp from pter
End:
12,835,545 bp from pter
Size:
486,064 bases
Orientation:
Plus strand

Genomic View for CAMK1D Gene

Genes around CAMK1D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAMK1D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAMK1D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMK1D Gene

Proteins for CAMK1D Gene

  • Protein details for CAMK1D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IU85-KCC1D_HUMAN
    Recommended name:
    Calcium/calmodulin-dependent protein kinase type 1D
    Protein Accession:
    Q8IU85
    Secondary Accessions:
    • B0YIY0
    • Q9HD31

    Protein attributes for CAMK1D Gene

    Size:
    385 amino acids
    Molecular mass:
    42914 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CAMK1D Gene

    Alternative splice isoforms for CAMK1D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CAMK1D Gene

Proteomics data for CAMK1D Gene at MOPED

Post-translational modifications for CAMK1D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CAMK1D Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CAMK1D (CAMK1D)

Domains & Families for CAMK1D Gene

Gene Families for CAMK1D Gene

Graphical View of Domain Structure for InterPro Entry

Q8IU85

UniProtKB/Swiss-Prot:

KCC1D_HUMAN :
  • The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Domain:
  • The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
genes like me logo Genes that share domains with CAMK1D: view

Function for CAMK1D Gene

Molecular function for CAMK1D Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows phosphorylation of Thr-180 within the activation loop by CaMKK1 or CaMKK2. Phosphorylation of Thr-180 results in several fold increase in total activity. Unlike CaMK4, may be unable to exhibit autonomous activity after Ca(2+)/calmodulin activation.
UniProtKB/Swiss-Prot Function:
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.
UniProtKB/Swiss-Prot Induction:
Expression increases upon treatment of EC cells with DMSO and retinoic acid. Induced by KCL in PC12 cells.

Enzyme Numbers (IUBMB) for CAMK1D Gene

Gene Ontology (GO) - Molecular Function for CAMK1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CAMK1D: view
genes like me logo Genes that share phenotypes with CAMK1D: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CAMK1D

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CAMK1D Gene

Localization for CAMK1D Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMK1D Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nuclear localization increases upon activation by KCl treatment in hippocampal neurons.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAMK1D Gene COMPARTMENTS Subcellular localization image for CAMK1D gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for CAMK1D Gene

Pathways & Interactions for CAMK1D Gene

genes like me logo Genes that share pathways with CAMK1D: view

Pathways by source for CAMK1D Gene

1 Sino Biological pathway for CAMK1D Gene
1 Cell Signaling Technology pathway for CAMK1D Gene
1 PharmGKB pathway for CAMK1D Gene

Interacting Proteins for CAMK1D Gene

Selected Interacting proteins: Q8IU85-KCC1D_HUMAN for CAMK1D Gene via I2D

Gene Ontology (GO) - Biological Process for CAMK1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0006954 inflammatory response IEA --
GO:0010976 positive regulation of neuron projection development ISS --
GO:0043065 positive regulation of apoptotic process IEA --
GO:0050766 positive regulation of phagocytosis IMP 15840691
genes like me logo Genes that share ontologies with CAMK1D: view

No data available for SIGNOR curated interactions for CAMK1D Gene

Drugs & Compounds for CAMK1D Gene

(4) Drugs for CAMK1D Gene - From: DrugBank, PharmGKB, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Losartan Approved Pharma Antagonist 277
Adenosine triphosphate Approved Nutra 0
N-(5-METHYL-1H-PYRAZOL-3-YL)-2-PHENYLQUINAZOLIN-4-AMINE Experimental Pharma Target 0
calcium Nutra 0

(2) Additional Compounds for CAMK1D Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with CAMK1D: view

Transcripts for CAMK1D Gene

Unigene Clusters for CAMK1D Gene

Calcium/calmodulin-dependent protein kinase ID:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAMK1D Gene

No ASD Table

Relevant External Links for CAMK1D Gene

GeneLoc Exon Structure for
CAMK1D
ECgene alternative splicing isoforms for
CAMK1D

Expression for CAMK1D Gene

mRNA expression in normal human tissues for CAMK1D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CAMK1D Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.8).

Protein differential expression in normal tissues from HIPED for CAMK1D Gene

This gene is overexpressed in Brain (10.5), Peripheral blood mononuclear cells (10.1), Lung (8.3), and Pancreas (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CAMK1D Gene



SOURCE GeneReport for Unigene cluster for CAMK1D Gene Hs.659517

mRNA Expression by UniProt/SwissProt for CAMK1D Gene

Q8IU85-KCC1D_HUMAN
Tissue specificity: Widely expressed. Highly and mostly expressed in polymorphonuclear leukocytes (neutrophilic and eosinophilic granulocytes) while little or no expression is observed in monocytes and lymphocytes.
genes like me logo Genes that share expression patterns with CAMK1D: view

Protein tissue co-expression partners for CAMK1D Gene

Primer Products

Orthologs for CAMK1D Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAMK1D Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CAMK1D 35
  • 91.55 (n)
  • 97.75 (a)
CAMK1D 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAMK1D 35
  • 91.43 (n)
  • 98.18 (a)
CAMK1D 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Camk1d 35
  • 90.56 (n)
  • 97.66 (a)
Camk1d 16
Camk1d 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CAMK1D 35
  • 99.31 (n)
  • 99.74 (a)
CAMK1D 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Camk1d 35
  • 90.3 (n)
  • 97.66 (a)
oppossum
(Monodelphis domestica)
Mammalia CAMK1D 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAMK1D 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves CAMK1D 35
  • 82.68 (n)
  • 92.99 (a)
CAMK1D 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAMK1D 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia camk1d 35
  • 76.19 (n)
  • 87.01 (a)
zebrafish
(Danio rerio)
Actinopterygii camk1da 35
  • 77.85 (n)
  • 88.72 (a)
camk1da 36
  • 73 (a)
OneToMany
camk1db 36
  • 77 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMK1 35
  • 49.94 (n)
  • 42.24 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons CPK20 35
  • 47.01 (n)
  • 40.39 (a)
rice
(Oryza sativa)
Liliopsida Os03g0788500 35
  • 51.17 (n)
  • 41.81 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 63 (a)
OneToMany
Species with no ortholog for CAMK1D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CAMK1D Gene

ENSEMBL:
Gene Tree for CAMK1D (if available)
TreeFam:
Gene Tree for CAMK1D (if available)

Paralogs for CAMK1D Gene

genes like me logo Genes that share paralogs with CAMK1D: view

Variants for CAMK1D Gene

Sequence variations from dbSNP and Humsavar for CAMK1D Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs34194224 - 12,553,330(+) AGCAT(A/G)GAGAA reference, missense
rs1536529 -- 12,479,908(+) GTTCT(C/T)AACGA intron-variant
rs1536530 -- 12,480,004(+) CATTG(G/T)TGGGG intron-variant
rs1536531 -- 12,480,145(+) TACCA(A/G)AATAA intron-variant
rs1536532 -- 12,486,577(+) TGTTT(C/T)TCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CAMK1D Gene

Variant ID Type Subtype PubMed ID
esv2676569 CNV Deletion 23128226
nsv894881 CNV Gain 21882294
esv2601612 CNV Insertion 19546169
nsv513006 CNV Insertion 21212237
esv2658042 CNV Deletion 23128226
nsv517854 CNV Loss 19592680
esv29514 CNV Loss 19812545
nsv522620 CNV Loss 19592680
esv2673513 CNV Deletion 23128226
esv24335 CNV Gain 19812545
nsv466740 CNV Gain 19166990
nsv470920 CNV Gain 18288195
nsv894882 CNV Loss 21882294
nsv466741 CNV Loss 19166990
nsv831786 CNV Loss 17160897
nsv894883 CNV Loss 21882294
esv2666513 CNV Deletion 23128226
nsv512147 CNV Loss 21212237
esv1011108 CNV Deletion 20482838
esv2505519 CNV Deletion 19546169
esv2045613 CNV Deletion 18987734
esv2733162 CNV Deletion 23290073
esv3029 CNV Deletion 18987735
esv7711 CNV Loss 19470904
esv1750238 CNV Deletion 17803354
nsv498720 CNV Loss 21111241
esv1543093 CNV Deletion 17803354
esv2733173 CNV Deletion 23290073
esv3331 CNV Deletion 18987735
esv2662299 CNV Deletion 23128226
esv1080827 CNV Deletion 17803354
esv2675595 CNV Deletion 23128226
nsv466742 CNV Loss 19166990
nsv470921 CNV Loss 18288195
nsv510212 CNV Loss 20534489
nsv524505 CNV Loss 19592680
esv2733184 CNV Deletion 23290073
esv2673405 CNV Deletion 23128226
esv2316922 CNV Deletion 18987734
esv2733195 CNV Deletion 23290073
nsv825249 CNV Loss 20364138
esv2657367 CNV Deletion 23128226
esv1681196 CNV Deletion 17803354
esv2733206 CNV Deletion 23290073
nsv520469 CNV Loss 19592680
nsv507540 CNV Insertion 20534489
esv2733217 CNV Deletion 23290073
nsv24363 CNV Loss 16902084
nsv894884 CNV Gain 21882294
dgv105e201 CNV Deletion 23290073
esv2494590 CNV Deletion 19546169
esv2733239 CNV Deletion 23290073
esv22086 CNV Loss 19812545
nsv820494 CNV Deletion 20802225
esv2733262 CNV Deletion 23290073
esv2733273 CNV Deletion 23290073
esv2733284 CNV Deletion 23290073

Variation tolerance for CAMK1D Gene

Residual Variation Intolerance Score: 19.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.59; 12.69% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CAMK1D Gene

Disorders for CAMK1D Gene

Relevant External Links for CAMK1D

Genetic Association Database (GAD)
CAMK1D
Human Genome Epidemiology (HuGE) Navigator
CAMK1D
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAMK1D

No disorders were found for CAMK1D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAMK1D Gene

Publications for CAMK1D Gene

  1. Identification and characterization of CKLiK, a novel granulocyte Ca++/calmodulin-dependent protein kinase. (PMID: 11050006) Verploegen S. … Coffer P.J. (Blood 2000) 2 3 4 23 67
  2. CAMK1D amplification implicated in epithelial-mesenchymal transition in basal-like breast cancer. (PMID: 19383354) Bergamaschi A. … Pollack J.R. (Mol Oncol 2008) 3 23
  3. Characterization of the role of CaMKI-like kinase (CKLiK) in human granulocyte function. (PMID: 15840691) Verploegen S. … Coffer P.J. (Blood 2005) 3 23
  4. Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells. (PMID: 12935886) Ishikawa Y. … Kobayashi R. (FEBS Lett. 2003) 3 23
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for CAMK1D Gene

Sources for CAMK1D Gene

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