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Aliases for CAMK1 Gene

Aliases for CAMK1 Gene

  • Calcium/Calmodulin-Dependent Protein Kinase I 2 3
  • CaM Kinase I Alpha 3 4
  • EC 2.7.11.17 4 64
  • CaMKI-Alpha 3 4
  • CaM-KI 3 4
  • CAMKI 3 6
  • Calcium/Calmodulin-Dependent Protein Kinase Type 1 3
  • CaM Kinase I 4
  • EC 2.7.11 64

External Ids for CAMK1 Gene

Summaries for CAMK1 Gene

Entrez Gene Summary for CAMK1 Gene

  • Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAMK1 Gene

CAMK1 (Calcium/Calmodulin-Dependent Protein Kinase I) is a Protein Coding gene. Among its related pathways are GPCR Pathway and Activation of cAMP-Dependent PKA. GO annotations related to this gene include calmodulin binding and calmodulin-dependent protein kinase activity. An important paralog of this gene is DCX.

UniProtKB/Swiss-Prot for CAMK1 Gene

  • Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on Ser-694, which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on Ser-91, Ser-92, Ser-93 and Ser-294. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of Ser-259 and Ser-498 in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on Ser-276 and Ser-295. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I.

Gene Wiki entry for CAMK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMK1 Gene

Genomics for CAMK1 Gene

Genomic Location for CAMK1 Gene

Start:
9,757,342 bp from pter
End:
9,769,992 bp from pter
Size:
12,651 bases
Orientation:
Minus strand

Genomic View for CAMK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CAMK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMK1 Gene

Regulatory Elements for CAMK1 Gene

Proteins for CAMK1 Gene

  • Protein details for CAMK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14012-KCC1A_HUMAN
    Recommended name:
    Calcium/calmodulin-dependent protein kinase type 1
    Protein Accession:
    Q14012
    Secondary Accessions:
    • Q3KPF6

    Protein attributes for CAMK1 Gene

    Size:
    370 amino acids
    Molecular mass:
    41337 Da
    Quaternary structure:
    • Monomer. Interacts with XPO1 (By similarity). Interacts with MARK2, ARHGEF7/BETAPIX and GIT1.

    Three dimensional structures from OCA and Proteopedia for CAMK1 Gene

neXtProt entry for CAMK1 Gene

Proteomics data for CAMK1 Gene at MOPED

Post-translational modifications for CAMK1 Gene

  • Phosphorylated by CaMKK1 and CaMKK2 on Thr-177.
  • Polybiquitinated by the E3 ubiquitin-protein ligase complex SCF(FBXL12), leading to proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys59

Other Protein References for CAMK1 Gene

Domains for CAMK1 Gene

Gene Families for CAMK1 Gene

UniProtKB/Swiss-Prot:

KCC1A_HUMAN
Domain:
  • The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.:
    • Q14012
  • Contains 1 protein kinase domain.:
    • Q14012
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.:
    • Q14012
genes like me logo Genes that share domains with CAMK1: view

Function for CAMK1 Gene

Molecular function for CAMK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows phosphorylation of Thr-177 within the activation loop by CaMKK1 or CaMKK2. Phosphorylation of Thr-177 results in several fold increase in total activity. Unlike CaMK4, is unable to exhibit autonomous activity after Ca(2+)/calmodulin activation.
UniProtKB/Swiss-Prot Function: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on Ser-694, which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on Ser-91, Ser-92, Ser-93 and Ser-294. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of Ser-259 and Ser-498 in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on Ser-276 and Ser-295. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I.

Enzyme Numbers (IUBMB) for CAMK1 Gene

Gene Ontology (GO) - Molecular Function for CAMK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity --
GO:0004683 calmodulin-dependent protein kinase activity ISS --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 17442826
genes like me logo Genes that share ontologies with CAMK1: view

Phenotypes for CAMK1 Gene

genes like me logo Genes that share phenotypes with CAMK1: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CAMK1 Gene

Localization for CAMK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMK1 Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAMK1 Gene COMPARTMENTS Subcellular localization image for CAMK1 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CAMK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CAMK1: view

Pathways for CAMK1 Gene

genes like me logo Genes that share pathways with CAMK1: view

Pathways by source for CAMK1 Gene

2 GeneGo (Thomson Reuters Life Sciences Research) pathways for CAMK1 Gene
1 Sino Biological pathway for CAMK1 Gene
2 BioSystems pathways for CAMK1 Gene
1 PharmGKB pathway for CAMK1 Gene
1 KEGG pathway for CAMK1 Gene

Gene Ontology (GO) - Biological Process for CAMK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 11114197
GO:0006913 nucleocytoplasmic transport IEA --
GO:0007049 cell cycle IEA --
GO:0007165 signal transduction IEA --
GO:0010976 positive regulation of neuron projection development IDA 17442826
genes like me logo Genes that share ontologies with CAMK1: view

Compounds for CAMK1 Gene

(3) HMDB Compounds for CAMK1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Calcium
  • Ca
7440-70-2

(8) Novoseek inferred chemical compound relationships for CAMK1 Gene

Compound -log(P) Hits PubMed IDs
syntide-2 82.8 2
calcium 53.5 30
ionomycin 46.1 2
forskolin 33.1 1
atp 16 4
genes like me logo Genes that share compounds with CAMK1: view

Transcripts for CAMK1 Gene

Unigene Clusters for CAMK1 Gene

Calcium/calmodulin-dependent protein kinase I:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAMK1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10
SP1:
SP2:
SP3: -

Relevant External Links for CAMK1 Gene

GeneLoc Exon Structure for
CAMK1
ECgene alternative splicing isoforms for
CAMK1

Expression for CAMK1 Gene

mRNA expression in normal human tissues for CAMK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAMK1 Gene

SOURCE GeneReport for Unigene cluster for CAMK1 Gene Hs.434875

mRNA Expression by UniProt/SwissProt for CAMK1 Gene

Q14012-KCC1A_HUMAN
Tissue specificity: Widely expressed. Expressed in cells of the zona glomerulosa of the adrenal cortex.
genes like me logo Genes that share expressions with CAMK1: view

Orthologs for CAMK1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAMK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CAMK1 36
  • 99.55 (n)
  • 99.46 (a)
CAMK1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CAMK1 36
  • 91.71 (n)
  • 95.68 (a)
CAMK1 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAMK1 36
  • 91.71 (n)
  • 96.49 (a)
CAMK1 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Camk1 36
  • 91.28 (n)
  • 97.82 (a)
Camk1 16
Camk1 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CAMK1 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAMK1 37
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Camk1 36
  • 91.01 (n)
  • 98.09 (a)
chicken
(Gallus gallus)
Aves CAMK1 36
  • 80.94 (n)
  • 87.04 (a)
CAMK1 37
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAMK1 37
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia camk1-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia camk1 36
  • 75.84 (n)
  • 84.27 (a)
Str.2740 36
zebrafish
(Danio rerio)
Actinopterygii BX571768.1 37
  • 76 (a)
OneToMany
CAMK1 (2 of 2) 37
  • 72 (a)
OneToMany
LOC794026 36
  • 77.11 (n)
  • 85.37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CaMKI 38
  • 64 (a)
worm
(Caenorhabditis elegans)
Secernentea cmk-1 38
  • 66 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR009W 36
  • 51.57 (n)
  • 40.6 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMK1 39
CMK2 36
  • 50.11 (n)
  • 42 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F23155g 36
  • 46.65 (n)
  • 39.61 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons CPK1 36
  • 51.59 (n)
  • 42.52 (a)
rice
(Oryza sativa)
Liliopsida Os12g0486600 36
  • 53.33 (n)
  • 42 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09123 36
  • 52.71 (n)
  • 43.19 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8378 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 63 (a)
OneToMany
Species with no ortholog for CAMK1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAMK1 Gene

ENSEMBL:
Gene Tree for CAMK1 (if available)
TreeFam:
Gene Tree for CAMK1 (if available)

Paralogs for CAMK1 Gene

genes like me logo Genes that share paralogs with CAMK1: view

Variants for CAMK1 Gene

Sequence variations from dbSNP and Humsavar for CAMK1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
VAR_040596 A metastatic melanoma sample
VAR_040597 -

Structural Variations from Database of Genomic Variants (DGV) for CAMK1 Gene

Variant ID Type Subtype PubMed ID
nsv821982 CNV Gain 20364138

Relevant External Links for CAMK1 Gene

HapMap Linkage Disequilibrium report
CAMK1

Disorders for CAMK1 Gene

(1) Novoseek inferred disease relationships for CAMK1 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 0 2

Relevant External Links for CAMK1

Genetic Association Database (GAD)
CAMK1
Human Genome Epidemiology (HuGE) Navigator
CAMK1
genes like me logo Genes that share disorders with CAMK1: view

No data available for UniProtKB/Swiss-Prot for CAMK1 Gene

Publications for CAMK1 Gene

  1. Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase. (PMID: 7641687) Haribabu B. … Means A.R. (EMBO J. 1995) 2 3 4 23
  2. Calmodulin-dependent kinase I regulates adrenal cell expression of aldosterone synthase. (PMID: 12193581) Condon J.C. … Rainey W.E. (Endocrinology 2002) 3 4 23
  3. Regulation of cyclin D1/Cdk4 complexes by calcium/calmodulin- dependent protein kinase I. (PMID: 14754892) Kahl C.R. … Means A.R. (J. Biol. Chem. 2004) 3 4 23
  4. Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex. (PMID: 18184567) Saneyoshi T. … Soderling T.R. (Neuron 2008) 3 4 23
  5. Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I. (PMID: 14507913) Qin H. … Edelman A.M. (J. Biol. Chem. 2003) 3 4 23

Products for CAMK1 Gene

  • Addgene plasmids for CAMK1

Sources for CAMK1 Gene

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