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Aliases for CAMK1 Gene

Aliases for CAMK1 Gene

  • Calcium/Calmodulin Dependent Protein Kinase I 2 3
  • Calcium/Calmodulin-Dependent Protein Kinase I 3 5
  • CaM Kinase I Alpha 3 4
  • EC 2.7.11.17 4 63
  • CaMKI-Alpha 3 4
  • CaM-KI 3 4
  • CaM Kinase I 4
  • EC 2.7.11 63
  • CAMKI 3

External Ids for CAMK1 Gene

Previous GeneCards Identifiers for CAMK1 Gene

  • GC03U990094
  • GC03M009738

Summaries for CAMK1 Gene

Entrez Gene Summary for CAMK1 Gene

  • Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase. [provided by RefSeq, Jul 2008]

GeneCards Summary for CAMK1 Gene

CAMK1 (Calcium/Calmodulin Dependent Protein Kinase I) is a Protein Coding gene. Among its related pathways are Insulin secretion and Oxytocin signaling pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CAMK2D.

UniProtKB/Swiss-Prot for CAMK1 Gene

  • Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on Ser-694, which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on Ser-91, Ser-92, Ser-93 and Ser-294. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of Ser-259 and Ser-498 in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on Ser-276 and Ser-295. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I.

Gene Wiki entry for CAMK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CAMK1 Gene

Genomics for CAMK1 Gene

Regulatory Elements for CAMK1 Gene

Enhancers for CAMK1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CAMK1 on UCSC Golden Path with GeneCards custom track

Promoters for CAMK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CAMK1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CAMK1 Gene

Chromosome:
3
Start:
9,757,342 bp from pter
End:
9,769,992 bp from pter
Size:
12,651 bases
Orientation:
Minus strand

Genomic View for CAMK1 Gene

Genes around CAMK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CAMK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CAMK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CAMK1 Gene

Proteins for CAMK1 Gene

  • Protein details for CAMK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14012-KCC1A_HUMAN
    Recommended name:
    Calcium/calmodulin-dependent protein kinase type 1
    Protein Accession:
    Q14012
    Secondary Accessions:
    • Q3KPF6

    Protein attributes for CAMK1 Gene

    Size:
    370 amino acids
    Molecular mass:
    41337 Da
    Quaternary structure:
    • Monomer. Interacts with XPO1 (By similarity). Interacts with MARK2, ARHGEF7/BETAPIX and GIT1.

    Three dimensional structures from OCA and Proteopedia for CAMK1 Gene

neXtProt entry for CAMK1 Gene

Proteomics data for CAMK1 Gene at MOPED

Post-translational modifications for CAMK1 Gene

  • Phosphorylated by CaMKK1 and CaMKK2 on Thr-177.
  • Polybiquitinated by the E3 ubiquitin-protein ligase complex SCF(FBXL12), leading to proteasomal degradation.
  • Ubiquitination at Lys 59
  • Modification sites at PhosphoSitePlus

Other Protein References for CAMK1 Gene

Domains & Families for CAMK1 Gene

Gene Families for CAMK1 Gene

Graphical View of Domain Structure for InterPro Entry

Q14012

UniProtKB/Swiss-Prot:

KCC1A_HUMAN :
  • The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Domain:
  • The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
genes like me logo Genes that share domains with CAMK1: view

Function for CAMK1 Gene

Molecular function for CAMK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows phosphorylation of Thr-177 within the activation loop by CaMKK1 or CaMKK2. Phosphorylation of Thr-177 results in several fold increase in total activity. Unlike CaMK4, is unable to exhibit autonomous activity after Ca(2+)/calmodulin activation.
UniProtKB/Swiss-Prot Function:
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on Ser-694, which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on Ser-91, Ser-92, Ser-93 and Ser-294. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of Ser-259 and Ser-498 in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on Ser-276 and Ser-295. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I.

Enzyme Numbers (IUBMB) for CAMK1 Gene

Gene Ontology (GO) - Molecular Function for CAMK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CAMK1: view
genes like me logo Genes that share phenotypes with CAMK1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CAMK1

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CAMK1 Gene

Localization for CAMK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CAMK1 Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CAMK1 Gene COMPARTMENTS Subcellular localization image for CAMK1 gene
Compartment Confidence
cytosol 4
nucleus 4
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for CAMK1 Gene

Pathways & Interactions for CAMK1 Gene

genes like me logo Genes that share pathways with CAMK1: view

Pathways by source for CAMK1 Gene

SIGNOR curated interactions for CAMK1 Gene

Inactivates:
Other effect:

Gene Ontology (GO) - Biological Process for CAMK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IDA 11114197
GO:0007165 signal transduction IEA --
GO:0010976 positive regulation of neuron projection development IDA 17442826
GO:0032091 negative regulation of protein binding IDA 23867755
GO:0032880 regulation of protein localization IDA 11114197
genes like me logo Genes that share ontologies with CAMK1: view

Drugs & Compounds for CAMK1 Gene

(7) Drugs for CAMK1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
calcium Nutra 0

(3) Additional Compounds for CAMK1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with CAMK1: view

Transcripts for CAMK1 Gene

Unigene Clusters for CAMK1 Gene

Calcium/calmodulin-dependent protein kinase I:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CAMK1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10
SP1:
SP2:
SP3: -

Relevant External Links for CAMK1 Gene

GeneLoc Exon Structure for
CAMK1
ECgene alternative splicing isoforms for
CAMK1

Expression for CAMK1 Gene

mRNA expression in normal human tissues for CAMK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CAMK1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.6), Platelet (13.1), and Bone (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CAMK1 Gene



SOURCE GeneReport for Unigene cluster for CAMK1 Gene Hs.434875

mRNA Expression by UniProt/SwissProt for CAMK1 Gene

Q14012-KCC1A_HUMAN
Tissue specificity: Widely expressed. Expressed in cells of the zona glomerulosa of the adrenal cortex.
genes like me logo Genes that share expression patterns with CAMK1: view

Protein tissue co-expression partners for CAMK1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CAMK1 Gene

Orthologs for CAMK1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CAMK1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CAMK1 35
  • 91.71 (n)
  • 95.68 (a)
CAMK1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CAMK1 35
  • 91.71 (n)
  • 96.49 (a)
CAMK1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Camk1 35
  • 91.28 (n)
  • 97.82 (a)
Camk1 16
Camk1 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CAMK1 35
  • 99.55 (n)
  • 99.46 (a)
CAMK1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Camk1 35
  • 91.01 (n)
  • 98.09 (a)
oppossum
(Monodelphis domestica)
Mammalia CAMK1 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CAMK1 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves CAMK1 35
  • 80.94 (n)
  • 87.04 (a)
CAMK1 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CAMK1 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia camk1 35
  • 75.84 (n)
  • 84.27 (a)
Str.2740 35
African clawed frog
(Xenopus laevis)
Amphibia camk1-prov 35
zebrafish
(Danio rerio)
Actinopterygii LOC794026 35
  • 77.11 (n)
  • 85.37 (a)
BX571768.1 36
  • 76 (a)
OneToMany
CAMK1 (2 of 2) 36
  • 72 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CaMKI 37
  • 64 (a)
worm
(Caenorhabditis elegans)
Secernentea cmk-1 37
  • 66 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR009W 35
  • 51.57 (n)
  • 40.6 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F23155g 35
  • 46.65 (n)
  • 39.61 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMK2 35
  • 50.11 (n)
  • 42 (a)
CMK1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons CPK1 35
  • 51.59 (n)
  • 42.52 (a)
rice
(Oryza sativa)
Liliopsida Os12g0486600 35
  • 53.33 (n)
  • 42 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8378 35
bread mold
(Neurospora crassa)
Ascomycetes NCU09123 35
  • 52.71 (n)
  • 43.19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 63 (a)
OneToMany
Species with no ortholog for CAMK1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CAMK1 Gene

ENSEMBL:
Gene Tree for CAMK1 (if available)
TreeFam:
Gene Tree for CAMK1 (if available)

Paralogs for CAMK1 Gene

genes like me logo Genes that share paralogs with CAMK1: view

Variants for CAMK1 Gene

Sequence variations from dbSNP and Humsavar for CAMK1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_040596 A metastatic melanoma sample
VAR_040597 -

Structural Variations from Database of Genomic Variants (DGV) for CAMK1 Gene

Variant ID Type Subtype PubMed ID
nsv821982 CNV Gain 20364138

Variation tolerance for CAMK1 Gene

Residual Variation Intolerance Score: 28.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.12; 22.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CAMK1 Gene

HapMap Linkage Disequilibrium report
CAMK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMK1 Gene

Disorders for CAMK1 Gene

Relevant External Links for CAMK1

Genetic Association Database (GAD)
CAMK1
Human Genome Epidemiology (HuGE) Navigator
CAMK1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CAMK1

No disorders were found for CAMK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CAMK1 Gene

Publications for CAMK1 Gene

  1. Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase. (PMID: 7641687) Haribabu B. … Means A.R. (EMBO J. 1995) 2 3 4 23 67
  2. Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex. (PMID: 18184567) Saneyoshi T. … Soderling T.R. (Neuron 2008) 3 23
  3. Regulation of cyclin D1/Cdk4 complexes by calcium/calmodulin- dependent protein kinase I. (PMID: 14754892) Kahl C.R. … Means A.R. (J. Biol. Chem. 2004) 3 23
  4. Calcium/calmodulin-dependent protein kinase I inhibits neuronal nitric-oxide synthase activity through serine 741 phosphorylation. (PMID: 15251453) Song T. … Watanabe Y. (FEBS Lett. 2004) 3 23
  5. Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I. (PMID: 14507913) Qin H. … Edelman A.M. (J. Biol. Chem. 2003) 3 23

Products for CAMK1 Gene

Sources for CAMK1 Gene

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