CAMK1 Gene
protein-coding GIFtS: 61
GCID: GC03M009774
|
|
calcium/calmodulin-dependent protein kinase I
| |
Aliases
for CAMK1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Calcium/Calmodulin-Dependent Protein Kinase I1 2 | | CaMKI-Alpha1 | | CaM Kinase I Alpha2 3 | | Calcium/Calmodulin-Dependent Protein Kinase Type 12 | | EC 2.7.11.173 8 | | CaM-KI3 | | CAMKI2 5 | | CaMKI-Alpha1 | | CaMKI1 | | CaM Kinase I3 | | CaM-KI3 | | EC 2.7.118 |
Export aliases for CAMK1 gene to outside databasesPrevious GC identifers: GC03U990094 GC03M009738 |
Summaries
for CAMK1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CAMK1:
Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependentprotein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by bindingto the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme bycalcium/calmodulin-dependent protein kinase I kinase. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: KCC1A_HUMAN, Q14012Function: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signalingcascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, celldifferentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence[MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellarnerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and isessential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream ofNMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylatingARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotesneuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92','Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation ofNUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration ofmedulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation ofcyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulationof the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. Invitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I
Gene Wiki entry for CAMK1
|
Genomic Views
for CAMK1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CAMK1 gene promoter:
CREB NF-1 POU2F1 POU2F1a deltaCREB Lmo2 RelA NF-kappaB NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CAMK1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CAMK1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p25.3 Ensembl cytogenetic band: 3p25.3 HGNC cytogenetic band: 3p25.3CAMK1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M009774: view genomic region
(about GC identifiers)
Start:
|
9,799,026 bp from pter |
End:
|
9,811,676 bp from pter |
Size:
|
12,651 bases |
Orientation:
|
minus strand |
|
Proteins
for CAMK1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KCC1A_HUMAN, Q14012 (See
protein sequence)Recommended Name: Calcium/calmodulin-dependent protein kinase type 1 Size: 370 amino acids; 41337 Da
Subunit: Monomer. Interacts with XPO1 (By similarity). Interacts with MARK2, ARHGEF7/BETAPIX and GIT1
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Note=Predominantly cytoplasmic (Bysimilarity)
4 PDB 3D structures from  and Proteopedia  for CAMK1:4FG7 (3D)
4FG8 (3D)
4FG9 (3D)
4FGB (3D)
Secondary accessions: Q3KPF6Explore the universe of human proteins at neXtProt for CAMK1: NX_Q14012
Post-translational modifications:
Phosphorylated by CaMKK1 and CaMKK2 on Thr-1771
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14012
4/14 DME Specific Peptides for CAMK1 (Q14012) (see all 14)
CAMK1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003647.1
ENSEMBL proteins: ENSP00000256460 ENSP00000393238 ENSP00000380447 ENSP00000404587
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
CAMK1 for ontologies About GeneDecksing
CAMK1 Antibody Products:
Assay Products for CAMK1: |
Protein
Domains /
Families
for CAMK1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CAMK1 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q14012ProtoNet protein and cluster: Q14012 UniProtKB/Swiss-Prot: KCC1A_HUMAN, Q14012Domain: The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive foldedstate with the catalytic domain as a pseudosubstrate (By similarity)Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamilySimilarity: Contains 1 protein kinase domain |
Function
for CAMK1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KCC1A_HUMAN, Q14012Function: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signalingcascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, celldifferentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence[MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellarnerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and isessential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream ofNMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylatingARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotesneuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92','Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation ofNUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration ofmedulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation ofcyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulationof the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. Invitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin ICatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relievesintrasteric autoinhibition and allows phosphorylation of Thr-177 within the activation loop by CaMKK1 or CaMKK2.Phosphorylation of Thr-177 results in several fold increase in total activity. Unlike CaMK4, is unable to exhibitautonomous activity after Ca(2+)/calmodulin activationEnzyme Numbers (IUBMB): EC 2.7.11.171 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAMK1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAMK1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CAMK1 (NM_003656) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CAMK1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMK1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMK1 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
CAMK1 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for CAMK1:
Animal Models:
Mouse knock-out Camk1tm1Mpic for CAMK1
1 MGI phenotypic allele  for Camk1 (no phenotypes)
CAMK1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CAMK1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Immune response_Function of MEF2 in T lymphocytes | | | 2 | Signal transduction Calcium signaling | | | 3 | NFAT and Cardiac Hypertrophy | | | 4 | Activation of cAMP-Dependent PKA | | | 5 | Calcium Regulation in the Cardiac Cell | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for CAMK1
5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CAMK1 (see all 8)
2  GeneGo (Thomson Reuters) Pathways for CAMK1
1  BioSystems Pathway for CAMK1
1  PharmGKB Pathway for CAMK1
CAMK1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CAMK1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
5/16 Interacting proteins for CAMK1 (Q140123 ENSP000002564604) via UniProtKB, MINT, STRING, and/or I2D (see all 16)About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table
CAMK1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CAMK1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CAMK1 for compounds About GeneDecksing
 Browse Tocris compounds for CAMK1
3 HMDB Compounds for CAMK1 About this table
8 Novoseek chemical compound relationships for CAMK1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| syntide-2 |
82.8 |
3 |
7559563 (1), 9395448 (1) |
| calcium |
53.5 |
39 |
8702851 (5), 15689566 (2), 8601311 (2), 12538590 (2) (see all 22) |
| ionomycin |
46.1 |
3 |
8702851 (1), 12193581 (1) |
| forskolin |
33.1 |
1 |
10187789 (1) |
| atp |
16 |
5 |
14558884 (1), 10571231 (1), 7559563 (1), 9395448 (1) |
| cyclic amp |
1.61 |
1 |
1646483 (1) |
| nmda |
1.32 |
3 |
15689566 (2), 18184567 (1) |
| nitric oxide |
0 |
3 |
11278815 (2), 15752366 (1) |
Search CenterWatch for drugs/clinical trials and news about CAMK1 / KCC1A
|
Transcripts
for CAMK1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CAMK1 gene: NM_003656.4 Unigene Cluster for CAMK1: Calcium/calmodulin-dependent protein kinase I Hs.434875 [show with all ESTs]Unigene Representative Sequence: AB2093956 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000256460(uc003bst.3) ENST00000496534(uc003bss.3) ENST00000421120
ENST00000482803 ENST00000397277 ENST00000411972
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAMK1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAMK1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CAMK1 (NM_003656) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CAMK1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMK1 |
Additional cDNA sequence: AB209395.1 AB451277.1 AB451407.1 AK094026.1 AK314917.1 BC106754.2 BC106755.2 L41816.1 15 DOTS entries: DT.451620 DT.95254839 DT.97824336 DT.100827161 DT.100827171 DT.100028715 DT.120858256 DT.97766475 DT.92443590 DT.92443608 DT.75183545 DT.100827172 DT.120858138 DT.95254860 DT.95336143 24/647 AceView cDNA sequences (see all 647): AI184552 BU543771 BI259284 BM693996 CD370744 BQ060758 AA005165 BQ646115 BQ277682 BC013433 CR607832 BM987134 BM474264 BE279559 BM998645 BM687422 BM990659 CR621015 BM662460 CA314582 BE396448 AI333405 BF341135 BQ029308
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for CAMK1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CAMK1
|
Expression
for CAMK1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CAMK1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCCTCTGCG
About this image
See CAMK1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CAMK1
SOURCE GeneReport for Unigene cluster: Hs.434875
UniProtKB/Swiss-Prot: KCC1A_HUMAN, Q14012Tissue specificity: Widely expressed. Expressed in cells of the zona glomerulosa of the adrenal cortex
SABiosciences Expression via Pathway-Focused PCR Array including CAMK1: | Nitric Oxide Signaling Pathway in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CAMK1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CAMK1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CAMK1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CAMK1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMK1 |
Orthologs
for CAMK1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CAMK1 gene from 9/33 species (see all 33) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CAMK11 |
calcium/calmodulin-dependent protein kinase I |
82.01(n)
89.09(a) |
|
416049 XM_414388.2 XP_414388.2 |
lizard
(Anolis carolinensis) |
Reptilia |
CAMK16 |
-- |
81(a) |
1 ↔ 1 |
2(191187281-191214572) |
African clawed frog
(Xenopus laevis) |
Amphibia |
camk1-prov2 |
calcium/calmodulin-dependent protein kinase I |
79.5(n) |
|
BC041721.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC7940261 |
calcium/calmodulin-dependent protein kinase type 1-like |
77.11(n)
85.37(a) |
|
794026 XM_001333889.1 XP_001333925.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CaMKI1 , 3 |
protein amino acid phosphorylation
calmodulin-dependent more3
Calcium/calmodulin-dependent protein kinase I1 |
64(a)3
61.15(n)1
64.72(a)1 |
|
102C13
437921 NM_079883.21 NP_524622.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
cmk-11 , 3 |
Protein CMK-11 |
66(a)3
62.15(n)1
67.19(a)1 |
|
IV(1824532-1833603)3
1769891 NM_067738.51 NP_500139.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
CMK1(YFR014C)4
CMK21 |
Calmodulin-dependent protein kinase; may play a role more4
Cmk2p1 |
50(n)1
41.67(a)1 |
|
6(173877-172537)4
8541441 NP_014626.11 8505684
NP_116669.14 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
CDPK91 |
calmodulin-like domain protein kinase 9 |
50.4(n)
44.03(a) |
|
832424 NM_122264.4 NP_197748.1 |
wheat
(Triticum aestivum) |
Liliopsida |
CD868030.12 |
-- |
72.45(n) |
|
CD868030.1 |
ENSEMBL Gene Tree for CAMK1 (if available)
TreeFam Gene Tree for CAMK1 (if available) |
Paralogs
for CAMK1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CAMK1 gene
- PNCK2 CAMK1G2 PSKH22 DCX2 DCLK22 CAMK2A2 CAMK1D2 DCLK12
- PSKH12 CAMK2D2 CAMK42 DCLK32 CAMKV2 CAMK2G2 CAMK2B2
18/135 SIMAP similar genes for CAMK1 using alignment to 6 protein entries: KCC1A_HUMAN (see all proteins)
(see all similar genes):CAMK1D PNCK CAMK1G PSKH1 MAPK4 PSKH2
STK11 CAMK4 CAMKV RPS6KA1 DCLK1 BRSK2
CHEK1 CDKL3 DCLK3 MGC45428 NEK5 RPS6KA3
CAMK1 for paralogs About GeneDecksing
|
Genomic Variants
for CAMK1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CAMK1 (9799026 - 9811676 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CAMK1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CAMK1 |
|
Disorders
/ Diseases
for CAMK1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CAMK1 for disorders About GeneDecksing
OMIM gene information: 604998
OMIM disorders: --
15  diseases for CAMK1: About MalaCardsdiffuse large b-cell lymphoma b-cell lymphomas anorexia nervosa adrenal adenoma
burkitt's lymphoma follicular lymphoma cystic fibrosis endometrial carcinoma
breast cancer aldosteronism adenoma medulloblastoma
fibrosis carcinoma neuronitis
1 Novoseek disease relationship for CAMK1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| breast cancer |
0 |
2 |
15958590 (2) |
Human Genome Epidemiology (HuGE) Navigator: CAMK1 (6 documents)
Export disorders for CAMK1 gene to outside databases
|
Publications
for CAMK1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for CAMK1 gene, integrated from 9 sources (see all 137):
(articles sorted by number of sources associating them with CAMK1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase. (PubMed id 7641687)1, 2, 3, 9 Haribabu B.... Means A.R. (1995)
- Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I. (PubMed id 14507913)1, 2, 9 Qin H.... Edelman A.M. (2003)
- Calmodulin-dependent kinase I regulates adrenal cell expression of aldosterone synthase. (PubMed id 12193581)1, 2, 9 Condon J.C....Rainey W.E. (2002)
- Regulation of cyclin D1/Cdk4 complexes by calcium/calmodulin-dependent protein kinase I. (PubMed id 14754892)1, 2, 9 Kahl C.R. and Means A.R. (2004)
- Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex. (PubMed id 18184567)1, 2, 9 Saneyoshi T....Soderling T.R. (2008)
- A calcium- and calmodulin-dependent kinase Ialpha/mic rotubule affinity regulating kinase 2 signaling cascade mediates calcium-depend ent neurite outgrowth. (PubMed id 17442826)1, 2 Uboha N.V....Picciotto M.R. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
- Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity. (PubMed id 11395482)1, 2 Hsu L.-S.... Chen J.-Y. (2001)
- Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14- 3-3 to histone deacetylase 5. (PubMed id 11114197)1, 2 McKinsey T.A.... Olson E.N. (2000)
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External Searches for CAMK1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing CAMK1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing CAMK1 gene
(According to HUGE)
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| -- |
Specialized Databases showing CAMK1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for CAMK1 gene:
Search GeneIP for patents involving CAMK1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CAMK1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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|
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| | |  | OriGene Antibodies for CAMK1 | | OriGene shRNA RFP for CAMK1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CAMK1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CAMK1 | | | OriGene Protein Over-expression Lysate for CAMK1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CAMK1 | | OriGene 3'-UTR Clone for CAMK1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CAMK1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CAMK1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CAMK1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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