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CAMK1 Gene

protein-coding   GIFtS: 67
GCID: GC03M009774

Calcium/Calmodulin-Dependent Protein Kinase I

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calcium/Calmodulin-Dependent Protein Kinase I1 2     Calcium/Calmodulin-Dependent Protein Kinase Type 12
CaM Kinase I Alpha2 3     CaM-KI3
EC 2.7.11.173 8     CaMKI-alpha3
CAMKI2 5     CaM Kinase I3
caM-KI2     EC 2.7.118
caMKI-alpha2     

External Ids:    HGNC: 14591   Entrez Gene: 85362   Ensembl: ENSG000001340727   OMIM: 6049985   UniProtKB: Q140123   

Export aliases for CAMK1 gene to outside databases

Previous GC identifers: GC03U990094 GC03M009738


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CAMK1 Gene:
Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a
calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent
protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation
of the enzyme by calcium/calmodulin-dependent protein kinase I kinase. (provided by RefSeq, Jul 2008)

GeneCards Summary for CAMK1 Gene:
CAMK1 (calcium/calmodulin-dependent protein kinase I) is a protein-coding gene. Diseases associated with CAMK1 include adrenal adenoma, and follicular lymphoma. GO annotations related to this gene include calmodulin binding and calmodulin-dependent protein kinase activity. An important paralog of this gene is PNCK.

UniProtKB/Swiss-Prot: KCC1A_HUMAN, Q14012
Function: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling
cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production,
cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus
sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal
and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in
hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent
translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in
hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7
activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and
phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and
binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation.
Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the
regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX
phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1
progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase
(CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates
CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I

Gene Wiki entry for CAMK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CAMK1 gene promoter:
         CREB   NF-1   POU2F1   POU2F1a   deltaCREB   Lmo2   RelA   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCAMK1 promoter sequence
   Search Chromatin IP Primers for CAMK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CAMK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.3   Ensembl cytogenetic band:  3p25.3   HGNC cytogenetic band: 3p25.3

CAMK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CAMK1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M009774:  view genomic region     (about GC identifiers)

Start:
9,799,026 bp from pter      End:
9,811,676 bp from pter
Size:
12,651 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KCC1A_HUMAN, Q14012 (See protein sequence)
Recommended Name: Calcium/calmodulin-dependent protein kinase type 1  
Size: 370 amino acids; 41337 Da
Subunit: Monomer. Interacts with XPO1 (By similarity). Interacts with MARK2, ARHGEF7/BETAPIX and GIT1
4 PDB 3D structures from and Proteopedia for CAMK1:
4FG7 (3D)        4FG8 (3D)        4FG9 (3D)        4FGB (3D)    
Secondary accessions: Q3KPF6

Explore the universe of human proteins at neXtProt for CAMK1: NX_Q14012

Explore proteomics data for CAMK1 at MOPED

Post-translational modifications: 

  • Phosphorylated by CaMKK1 and CaMKK2 on Thr-1771
  • Polybiquitinated by the E3 ubiquitin-protein ligase complex SCF(FBXL12), leading to proteasomal degradation1
  • Ubiquitination2 at Lys59
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CAMK1 (Q14012) (see all 14)
     GGELFDR  ENEIAVL  ISDSAKD  YVAPEVL 


    See CAMK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003647.1  
    ENSEMBL proteins: 
     ENSP00000256460   ENSP00000393238   ENSP00000380447   ENSP00000404587  

    CAMK1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CAMK1 Protein
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CAMK1
    OriGene Protein Over-expression Lysate for CAMK1
    OriGene MassSpec for CAMK1
    OriGene Custom Protein Services for CAMK1
    GenScript Custom Purified and Recombinant Proteins Services for CAMK1
    Novus Biologicals CAMK1 Proteins
    Novus Biologicals CAMK1 Lysate
    Sino Biological Recombinant Protein for CAMK1
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CAMK1

    CAMK1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals CAMK1 Antibodies
    Abcam antibodies for CAMK1
    Cloud-Clone Corp. Antibodies for CAMK1
    ThermoFisher Antibodies for CAMK1
    LSBio Antibodies in human, mouse, rat for CAMK1

    CAMK1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CAMK1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CAMK1
    Cloud-Clone Corp. CLIAs for CAMK1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: calcium/calmodulin-dependent protein kinase I
    CAMK1 family

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q14012

    ProtoNet protein and cluster: Q14012

    UniProtKB/Swiss-Prot: KCC1A_HUMAN, Q14012
    Domain: The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded
    state with the catalytic domain as a pseudosubstrate
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily
    Similarity: Contains 1 protein kinase domain


    CAMK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KCC1A_HUMAN, Q14012
    Function: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling
    cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production,
    cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus
    sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal
    and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in
    hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent
    translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in
    hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7
    activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and
    phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and
    binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation.
    Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the
    regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX
    phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1
    progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase
    (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates
    CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that
    relieves intrasteric autoinhibition and allows phosphorylation of Thr-177 within the activation loop by CaMKK1 or
    CaMKK2. Phosphorylation of Thr-177 results in several fold increase in total activity. Unlike CaMK4, is unable to
    exhibit autonomous activity after Ca(2+)/calmodulin activation

         Enzyme Numbers (IUBMB): EC 2.7.11.171 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004683calmodulin-dependent protein kinase activity ISS--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI17442826
         
    CAMK1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CAMK1:
     Cell division defect  Decreased substrate adherent c  Increased 8N DNA content 

         1 MGI phenotypic allele for Camk1 (no phenotypes)

    CAMK1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Camk1tm1Mpic for CAMK1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CAMK1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CAMK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CAMK1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CAMK1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CAMK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CAMK1 (see all 11):
    hsa-miR-623 hsa-miR-3163 hsa-miR-3149 hsa-miR-3688-3p hsa-miR-211 hsa-miR-204 hsa-miR-494 hsa-miR-297
    SwitchGear 3'UTR luciferase reporter plasmidCAMK1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CAMK1
    Predesigned siRNA for gene silencing in human, mouse, rat CAMK1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CAMK1

    Clone
    Products:
         
    OriGene clones in human, mouse for CAMK1 (see all 9)
    OriGene ORF clones in mouse, rat for CAMK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CAMK1 (NM_003656)
    Sino Biological Human cDNA Clone for CAMK1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CAMK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMK1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CAMK1
    Browse ESI BIO Cell Lines and PureStem Progenitors for CAMK1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CAMK1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KCC1A_HUMAN, Q14012: Cytoplasm (By similarity). Nucleus (By similarity). Note=Predominantly cytoplasmic (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    CAMK1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CAMK1 About   (see all 13)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    cAMP Pathway0.77
    2NFAT and Cardiac Hypertrophy
    NFAT and Cardiac Hypertrophy0.42
    IGF1R Signaling0.37
    3GPCR Pathway
    Breast Cancer Regulation by Stathmin10.58
    4ErbB signaling pathway
    EGFR Inhibitor Pathway, Pharmacodynamics0.49
    5Neuropathic Pain-Signaling in Dorsal Horn Neurons
    Neuropathic Pain-Signaling in Dorsal Horn Neurons0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CAMK1 (see all 8)
        Breast Cancer Regulation by Stathmin1
    Neuropathic Pain-Signaling in Dorsal Horn Neurons
    IGF1R Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA

    2 GeneGo (Thomson Reuters) Pathways for CAMK1
        Immune response Function of MEF2 in T lymphocytes
    Signal transduction Calcium signaling

    2 BioSystems Pathways for CAMK1
        Calcium Regulation in the Cardiac Cell
    BDNF signaling pathway

    1 Sino Biological Pathway for CAMK1
        EGFR Signaling Pathway

    1 PharmGKB Pathway for CAMK1
        EGFR Inhibitor Pathway, Pharmacodynamics

    1 Kegg Pathway  (Kegg details for CAMK1):
        Oxytocin signaling pathway


    CAMK1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CAMK1: 
              Nitric Oxide Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CAMK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CAMK1 (Q140123 ENSP000002564604) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=3 STRING: ENSP00000349467
    CALM2P621583I2D: score=3 
    CALM3P621583I2D: score=3 
    CAMKK2Q96RR43, ENSP000003127414I2D: score=4 STRING: ENSP00000312741
    ATF1P188463, ENSP000002620534I2D: score=2 STRING: ENSP00000262053
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA11114197
    GO:0006913nucleocytoplasmic transport IEA--
    GO:0007049cell cycle IEA--
    GO:0007165signal transduction IEA--
    GO:0010976positive regulation of neuron projection development IDA17442826

    CAMK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CAMK1 (KCC1A)

    3 HMDB Compounds for CAMK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--

    8 Novoseek inferred chemical compound relationships for CAMK1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    syntide-2 82.8 3 7559563 (1), 9395448 (1)
    calcium 53.5 39 8702851 (5), 15689566 (2), 8601311 (2), 12538590 (2) (see all 22)
    ionomycin 46.1 3 8702851 (1), 12193581 (1)
    forskolin 33.1 1 10187789 (1)
    atp 16 5 14558884 (1), 10571231 (1), 7559563 (1), 9395448 (1)
    cyclic amp 1.61 1 1646483 (1)
    nmda 1.32 3 15689566 (2), 18184567 (1)
    nitric oxide 0 3 11278815 (2), 15752366 (1)



    CAMK1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CAMK1 gene: 
    NM_003656.4  

    Unigene Cluster for CAMK1:

    Calcium/calmodulin-dependent protein kinase I
    Hs.434875  [show with all ESTs]
    Unigene Representative Sequence: AB209395
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256460(uc003bst.3) ENST00000496534(uc003bss.3) ENST00000421120
    ENST00000482803 ENST00000397277 ENST00000411972
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CAMK1 (see all 11):
    hsa-miR-623 hsa-miR-3163 hsa-miR-3149 hsa-miR-3688-3p hsa-miR-211 hsa-miR-204 hsa-miR-494 hsa-miR-297
    SwitchGear 3'UTR luciferase reporter plasmidCAMK1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: CAMK1 (NM_003656)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CAMK1
    Primer
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    OriGene qPCR primer pairs and template standards for CAMK1
    OriGene qSTAR qPCR primer pairs in human, mouse for CAMK1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CAMK1
      QuantiTect SYBR Green Assays in human, mouse, rat CAMK1
      QuantiFast Probe-based Assays in human, mouse, rat CAMK1

    Additional mRNA sequence: 

    AB209395.1 AB451277.1 AB451407.1 AK094026.1 AK314917.1 BC106754.2 BC106755.2 L41816.1 

    15 DOTS entries:

    DT.451620  DT.95254839  DT.97824336  DT.100827161  DT.100827171  DT.100028715  DT.120858256  DT.97766475 
    DT.92443590  DT.92443608  DT.75183545  DT.100827172  DT.120858138  DT.95254860  DT.95336143 

    Selected AceView cDNA sequences (see all 647):

    BQ646547 CA314582 BU607466 AW452950 CA416224 CR625213 CB141376 BF341135 
    BQ919223 AA548025 CD723027 AI289785 AA365983 BQ015737 BQ646115 BM983026 
    AF069733 BI523576 BQ772104 BE257892 AI084106 BM564595 BM984631 BQ219505 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CAMK1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10
    SP1:                                                                              
    SP2:                                                                              
    SP3:                    -                                                         


    ECgene alternative splicing isoforms for CAMK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CAMK1 expression in normal human tissues (normalized intensities)      CAMK1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCCTCTGCG
    CAMK1 Expression
    About this image


    CAMK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Adrenal Gland (Endocrine System)
    CAMK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CAMK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.434875

    UniProtKB/Swiss-Prot: KCC1A_HUMAN, Q14012
    Tissue specificity: Widely expressed. Expressed in cells of the zona glomerulosa of the adrenal cortex

        Pathway & Disease-focused RT2 Profiler PCR Array including CAMK1: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CAMK1 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Camk11 , 5 calcium/calmodulin-dependent protein kinase I1, 5 91.28(n)1
    97.82(a)1
      6 (52.75 cM)5
    521631  NM_133926.21  NP_598687.11 
     1133341245 
    chicken
    (Gallus gallus)
    Aves CAMK11 calcium/calmodulin-dependent protein kinase I 80.94(n)
    87.04(a)
      416049  XM_414388.3  XP_414388.3 
    lizard
    (Anolis carolinensis)
    Reptilia CAMK16
    calcium/calmodulin-dependent protein kinase I
    77(a)
    1 ↔ 1
    2(191180306-191214572)
    African clawed frog
    (Xenopus laevis)
    Amphibia camk1-prov2 calcium/calmodulin-dependent protein kinase I 79.5(n)    BC041721.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7940261 calcium/calmodulin-dependent protein kinase type 1-like 77.11(n)
    85.37(a)
      794026  XM_001333889.2  XP_001333925.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CMK1(YFR014C)4
    CMK21
    Calmodulin-dependent protein kinase; may play a role more4
    CMK21
    50.11(n)1
    42(a)1
      6(173877-172537)4
    8541441  NP_014626.11  8505684 
     NP_116669.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CPK11 CPK1 51.59(n)
    42.52(a)
      830366  NM_120569.2  NP_196107.1 
    rice
    (Oryza sativa)
    Liliopsida Os12g04866001 Os12g0486600 53.33(n)
    42(a)
      4352234  NM_001073318.1  NP_001066786.1 


    ENSEMBL Gene Tree for CAMK1 (if available)
    TreeFam Gene Tree for CAMK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CAMK1 gene
    PNCK2  CAMK1G2  PSKH22  DCX2  DCLK22  CAMK2A2  CAMK1D2  DCLK12  
    PSKH12  CAMK42  CAMK2D2  DCLK32  CAMKV2  CAMK2G2  CAMK2B2  
    Selected SIMAP similar genes for CAMK1 using alignment to 6 protein entries:     KCC1A_HUMAN (see all proteins) (see all similar genes):
    CAMK1D    PNCK    CAMK1G    MAPK4    PSKH1    PSKH2
    STK11    CAMK4    CAMKV    RPS6KA1    DAPK3    DCLK1
    BRSK2    CHEK1    CDKL3    DCLK3    MGC45428    RPS6KA3

    CAMK1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CAMK1 (see all 86)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0405964
    A metastatic melanoma sample4--see VAR_0405962 P S mis40--------
    rs1477437761,2
    --9808926(+) GAGCAC/TAGCAC 1 -- int10--------
    rs1132148041,2
    F--9808996(+) GGGCAG/AAGACC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1893053701,2
    --9809054(+) CCAGCC/TTCAGT 1 -- int10--------
    rs2937961,2
    C,F,H--9809082(-) AGCTAG/AGTGTT 1 -- int125Minor allele frequency- A:0.11NS EA NA WA CSA 2071
    rs1819680361,2
    --9809131(+) TCTCTC/TGACTT 1 -- int10--------
    rs1850103291,2
    --9809209(+) GAAAAG/TCTGGG 1 -- int10--------
    rs1906394181,2
    C--9809351(+) CTCACA/GTGCCC 2 T M mis10--------
    rs2010897221,2
    --9809356(+) GTGCCC/TAGAAC 2 L syn10--------
    rs1425622471,2
    C--9809395(+) TCCTCC/TGCCTG 2 A syn10--------

    HapMap Linkage Disequilibrium report for CAMK1 (9799026 - 9811676 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CAMK1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv821982CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604998    OMIM disorders: --

    17 diseases for CAMK1:    About MalaCards
    adrenal adenoma    follicular lymphoma    diffuse large b-cell lymphoma    anorexia nervosa
    b-cell lymphomas    burkitt's lymphoma    medulloblastoma    endometrial carcinoma
    cystic fibrosis    adenoma    breast cancer    hiv-1
    tonsillitis    malaria    neuronitis    thyroiditis
    prostatitis


    CAMK1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CAMK1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 0 2 15958590 (2)

    Genetic Association Database (GAD): CAMK1
    Human Genome Epidemiology (HuGE) Navigator: CAMK1 (6 documents)

    Export disorders for CAMK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CAMK1 gene, integrated from 10 sources (see all 142):
    (articles sorted by number of sources associating them with CAMK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase. (PubMed id 7641687)1, 2, 3, 9 Haribabu B.... Means A.R. (EMBO J. 1995)
    2. Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I. (PubMed id 14507913)1, 2, 9 Qin H.... Edelman A.M. (J. Biol. Chem. 2003)
    3. Calmodulin-dependent kinase I regulates adrenal cell expression of aldosterone synthase. (PubMed id 12193581)1, 2, 9 Condon J.C.... Rainey W.E. (Endocrinology 2002)
    4. Regulation of cyclin D1/Cdk4 complexes by calcium/calmodulin- dependent protein kinase I. (PubMed id 14754892)1, 2, 9 Kahl C.R. and Means A.R. (J. Biol. Chem. 2004)
    5. Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex. (PubMed id 18184567)1, 2, 9 Saneyoshi T.... Soderling T.R. (Neuron 2008)
    6. Fbxl12 triggers G1 arrest by mediating degradation of calmodulin kinase I. (PubMed id 23707388)1, 2 Mallampalli R.K....Agassandian M. (Cell. Signal. 2013)
    7. Crystal structures of human CaMKIalpha reveal insights into the regulation mechanism of CaMKI. (PubMed id 23028635)1, 2 Zha M.... Ding J. (PLoS ONE 2012)
    8. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8536 HGNC: 1459 AceView: CAMK1andTADA3L Ensembl:ENSG00000134072 euGenes: HUgn8536
    ECgene: CAMK1 Kegg: 8536 H-InvDB: CAMK1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CAMK1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CAMK1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CAMK1 gene:
    Search GeneIP for patents involving CAMK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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