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Aliases for CALY Gene

Aliases for CALY Gene

  • Calcyon Neuron-Specific Vesicular Protein 2 3
  • Dopamine Receptor D1 Interacting Protein 2 3
  • DRD1IP 3 4
  • Calcyon D1 Dopamine Receptor-Interacting Protein (CALCYON) 3
  • Neuron-Specific Vesicular Protein Calcyon 3
  • D1 Dopamine Receptor-Interacting Protein 3
  • Calcyon Protein 3
  • NSG3 3

External Ids for CALY Gene

Previous HGNC Symbols for CALY Gene

  • DRD1IP

Previous GeneCards Identifiers for CALY Gene

  • GC10M134989
  • GC10M135138
  • GC10M128683

Summaries for CALY Gene

Entrez Gene Summary for CALY Gene

  • The protein encoded by this gene is a type II single transmembrane protein. It is required for maximal stimulated calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. The encoded protein interacts with D1 dopamine receptor and may interact with other DA receptor subtypes and/or GPCRs. [provided by RefSeq, Jul 2008]

GeneCards Summary for CALY Gene

CALY (Calcyon Neuron-Specific Vesicular Protein) is a Protein Coding gene. Diseases associated with CALY include schizophrenia. Among its related pathways are Circadian entrainment. GO annotations related to this gene include clathrin light chain binding. An important paralog of this gene is HMP19.

UniProtKB/Swiss-Prot for CALY Gene

  • Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis.

Gene Wiki entry for CALY Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALY Gene

Genomics for CALY Gene

Regulatory Elements for CALY Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CALY Gene

Start:
133,325,423 bp from pter
End:
133,336,971 bp from pter
Size:
11,549 bases
Orientation:
Minus strand

Genomic View for CALY Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CALY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALY Gene

Proteins for CALY Gene

  • Protein details for CALY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYX4-CALY_HUMAN
    Recommended name:
    Neuron-specific vesicular protein calcyon
    Protein Accession:
    Q9NYX4
    Secondary Accessions:
    • Q5VWX3
    • Q5VWY5
    • Q5VWY6

    Protein attributes for CALY Gene

    Size:
    217 amino acids
    Molecular mass:
    23434 Da
    Quaternary structure:
    • Interacts with CLTA.

    Alternative splice isoforms for CALY Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CALY Gene

Proteomics data for CALY Gene at MOPED

Post-translational modifications for CALY Gene

Other Protein References for CALY Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CALY Gene

Domains for CALY Gene

Protein Domains for CALY Gene

Suggested Antigen Peptide Sequences for CALY Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYX4

UniProtKB/Swiss-Prot:

CALY_HUMAN :
  • Q9NYX4
Family:
  • Belongs to the NSG family.
genes like me logo Genes that share domains with CALY: view

No data available for Gene Families for CALY Gene

Function for CALY Gene

Molecular function for CALY Gene

UniProtKB/Swiss-Prot Function: Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis.

Gene Ontology (GO) - Molecular Function for CALY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032051 clathrin light chain binding IDA 16595675
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with CALY: view

Phenotypes for CALY Gene

MGI mutant phenotypes for CALY:
inferred from 2 alleles
GenomeRNAi human phenotypes for CALY:
genes like me logo Genes that share phenotypes with CALY: view

Animal Models for CALY Gene

MGI Knock Outs for CALY:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CALY

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CALY Gene

Localization for CALY Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALY Gene

Cytoplasmic vesicle membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CALY Gene COMPARTMENTS Subcellular localization image for CALY gene
Compartment Confidence
plasma membrane 5
cytosol 1
extracellular 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CALY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IDA 14534309
GO:0016021 integral component of membrane --
GO:0030659 cytoplasmic vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle IDA 14534309
genes like me logo Genes that share ontologies with CALY: view

Pathways for CALY Gene

SuperPathways for CALY Gene

Superpath Contained pathways
1 Circadian entrainment
genes like me logo Genes that share pathways with CALY: view

Pathways by source for CALY Gene

1 KEGG pathway for CALY Gene

Interacting Proteins for CALY Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000252939%0d%0a9606.ENSP00000327652%0d%0a9606.ENSP00000306129%0d%0a
Selected Interacting proteins: ENSP00000252939 Q9NYX4-CALY_HUMAN for CALY Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CALY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0007212 dopamine receptor signaling pathway IEA --
GO:0045807 positive regulation of endocytosis IMP 16595675
GO:0048268 clathrin coat assembly IDA 16595675
genes like me logo Genes that share ontologies with CALY: view

Compounds for CALY Gene

(2) HMDB Compounds for CALY Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Dopamine
  • 2-(3,4-Dihydroxyphenyl)ethylamine
62-31-7

(3) Drugbank Compounds for CALY Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Apomorphine
  • Apomorfin
41372-20-7 target agonist
Clozapine
5786-21-0 target unknown
Trifluoperazine
  • Trifluoperazin
117-89-5 target antagonist

(1) Novoseek inferred chemical compound relationships for CALY Gene

Compound -log(P) Hits PubMed IDs
calcium 12.6 1
genes like me logo Genes that share compounds with CALY: view

Transcripts for CALY Gene

Unigene Clusters for CALY Gene

Calcyon neuron-specific vesicular protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CALY

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CALY Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7
SP1: - - -
SP2: -
SP3: -
SP4:
SP5:

Relevant External Links for CALY Gene

GeneLoc Exon Structure for
CALY
ECgene alternative splicing isoforms for
CALY

Expression for CALY Gene

mRNA expression in normal human tissues for CALY Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CALY Gene

This gene is overexpressed in Brain - Hypothalamus (9.4), Pituitary (5.8), Brain - Nucleus accumbens (basal ganglia) (4.9), Brain - Frontal Cortex (BA9) (4.1), and Brain - Cortex (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CALY Gene

SOURCE GeneReport for Unigene cluster for CALY Gene Hs.148680

mRNA Expression by UniProt/SwissProt for CALY Gene

Q9NYX4-CALY_HUMAN
Tissue specificity: Expressed in the pyramidal cells of the prefrontal cortex, in hippothalamus and in caudate nucleus. No expression in spleen. Up-regulated in the prefrontal cortex of schizophrenic patients with nearly twice the levels of non-schizophrenics.
genes like me logo Genes that share expressions with CALY: view

In Situ Assay Products

Orthologs for CALY Gene

This gene was present in the common ancestor of mammals.

Orthologs for CALY Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CALY 35
  • 99.15 (n)
  • 98.98 (a)
CALY 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CALY 35
  • 79.3 (n)
  • 68.25 (a)
CALY 36
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CALY 35
  • 89.32 (n)
  • 88.83 (a)
CALY 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Caly 35
  • 85.74 (n)
  • 88.33 (a)
Caly 16
Caly 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 37 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 36 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Caly 35
  • 85.13 (n)
  • 87.69 (a)
Species with no ortholog for CALY:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CALY Gene

ENSEMBL:
Gene Tree for CALY (if available)
TreeFam:
Gene Tree for CALY (if available)

Paralogs for CALY Gene

Paralogs for CALY Gene

Selected SIMAP similar genes for CALY Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CALY: view

Variants for CALY Gene

Sequence variations from dbSNP and Humsavar for CALY Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs2275723 -- 133,326,131(+) GGAGG(A/G)GCCGG intron-variant
rs2298122 -- 133,328,068(+) CAAGA(G/T)AGCCC intron-variant
rs3810958 -- 133,336,528(-) GGCAC(A/C/G)AGGAT intron-variant, upstream-variant-2KB
rs3909035 -- 133,325,656(-) GGGGG(G/T)TGCGA intron-variant
rs3909036 -- 133,325,646(-) AATCC(C/G)AGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CALY Gene

Variant ID Type Subtype PubMed ID
nsv896182 CNV Loss 21882294
dgv856n71 CNV Loss 21882294
nsv528260 CNV Loss 19592680
dgv328e1 CNV Complex 17122850
nsv896258 CNV Loss 21882294
nsv832036 CNV Loss 17160897
dgv879n71 CNV Loss 21882294
dgv880n71 CNV Loss 21882294
nsv470980 CNV Loss 18288195
dgv2e196 CNV Duplication 17116639
dgv882n71 CNV Loss 21882294
essv9566 CNV CNV 17122850
dgv883n71 CNV Loss 21882294
dgv886n71 CNV Gain 21882294
dgv887n71 CNV Gain 21882294
essv20368 CNV CNV 17122850
nsv428243 CNV Gain 18775914
dgv122n27 CNV Loss 19166990
nsv896310 CNV Loss 21882294
dgv3e196 CNV Duplication 17116639
esv2750853 CNV Gain 17911159
dgv889n71 CNV Loss 21882294
nsv896314 CNV Gain 21882294
nsv832040 CNV Loss 17160897
nsv467509 CNV Loss 19166990
nsv8751 CNV Gain 18304495
nsv825672 CNV Gain 20364138

Relevant External Links for CALY Gene

HapMap Linkage Disequilibrium report
CALY

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALY Gene

Disorders for CALY Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CALY Gene including...

Search for CALY Gene in MalaCards »

(2) University of Copenhagen DISEASES for CALY Gene

(2) Novoseek inferred disease relationships for CALY Gene

Disease -log(P) Hits PubMed IDs
calcyon 98.4 6
schizophrenia 34.3 2

Relevant External Links for CALY

Genetic Association Database (GAD)
CALY
Human Genome Epidemiology (HuGE) Navigator
CALY
genes like me logo Genes that share disorders with CALY: view

No data available for UniProtKB/Swiss-Prot for CALY Gene

Publications for CALY Gene

  1. Dual signaling regulated by calcyon, a D1 dopamine receptor interacting protein. (PMID: 10698743) Lezcano N. … Bergson C. (Science 2000) 2 4 23
  2. Up-regulation of the D1 dopamine receptor-interacting protein, calcyon, in patients with schizophrenia. (PMID: 12622665) Koh P.O. … Lidow M.S. (Arch. Gen. Psychiatry 2003) 4 23
  3. CALCYON gene variation, schizophrenia, and cocaine dependence. (PMID: 14755439) Luo X. … Gelernter J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2004) 3 23
  4. Association of the calcyon gene (DRD1IP) with attention deficit/hyperactivity disorder. (PMID: 16172615) Laurin N. … Barr C.L. (Mol. Psychiatry 2005) 3 23
  5. Candidate gene analysis in an on-going genome-wide association study of attention-deficit hyperactivity disorder: suggestive association signals in ADRA1A. (PMID: 19352218) Elia J. … Hakonarson H. (Psychiatr. Genet. 2009) 3 48

Products for CALY Gene

Sources for CALY Gene

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