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CALY Gene

protein-coding   GIFtS: 57
GCID: GC10M135138

Calcyon Neuron-Specific Vesicular Protein

(Previous name: dopamine receptor D1 interacting protein)
(Previous symbol: DRD1IP)
  See CALY-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calcyon Neuron-Specific Vesicular Protein1 2     Calcyon D1 Dopamine Receptor-Interacting Protein (CALCYON)2
DRD1IP1 2 3     Calcyon Protein2
Dopamine Receptor D1 Interacting Protein1 2     D1 Dopamine Receptor-Interacting Protein2
NSG32     Neuron-Specific Vesicular Protein Calcyon2

External Ids:    HGNC: 179381   Entrez Gene: 506322   Ensembl: ENSG000001306437   OMIM: 6046475   UniProtKB: Q9NYX43   

Export aliases for CALY gene to outside databases

Previous GC identifers: GC10M134989 GC10M128683


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CALY Gene:
The protein encoded by this gene is a type II single transmembrane protein. It is required for maximal stimulated
calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. The encoded
protein interacts with D1 dopamine receptor and may interact with other DA receptor subtypes and/or GPCRs.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CALY Gene:
CALY (calcyon neuron-specific vesicular protein) is a protein-coding gene. Diseases associated with CALY include schizophrenia. GO annotations related to this gene include clathrin light chain binding. An important paralog of this gene is HMP19.

UniProtKB/Swiss-Prot: CALY_HUMAN, Q9NYX4
Function: Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated
endocytosis

Gene Wiki entry for CALY (DRD1IP) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CALY gene promoter:
         Elk-1   RFX1   HOXA3   Pax-5   MyoD   GATA-2   GATA-1   deltaCREB   Zic1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCALY promoter sequence
   Search Chromatin IP Primers for CALY

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CALY


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.3   Ensembl cytogenetic band:  10q26.3   HGNC cytogenetic band: 10q26.3

CALY Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALY gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M135138:  view genomic region     (about GC identifiers)

Start:
135,138,927 bp from pter      End:
135,150,475 bp from pter
Size:
11,549 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CALY_HUMAN, Q9NYX4 (See protein sequence)
Recommended Name: Neuron-specific vesicular protein calcyon  
Size: 217 amino acids; 23434 Da
Subunit: Interacts with CLTA
Caution: Was originally (PubMed:10698743) thought to interact with the D1 dopamine receptor (DRD1) and to play a
role in potentiating calcium ion-dependent signaling but this work was later retracted
Caution: In cerebrospinal fluid (CSF), found to be O-glycosylated in the predicted intracellular region at Thr-180
and Thr-189 (PubMed:19838169). This glycosylation has been confirmed by a separate mass spectrometry (MS) method
(PubMed:23234360). Glycosylation in this region of the protein is unexplained as yet
Secondary accessions: Q5VWX3 Q5VWY5 Q5VWY6
Alternative splicing: 3 isoforms:  Q9NYX4-1   Q9NYX4-2   Q9NYX4-3   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for CALY: NX_Q9NYX4

Explore proteomics data for CALY at MOPED

Post-translational modifications: 

  • Glycosylated (Probable)1
  • Glycosylation2 at Asn73
  • Modification sites at PhosphoSitePlus

  • See CALY Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056537.1  
    ENSEMBL proteins: 
     ENSP00000252939   ENSP00000357546   ENSP00000357543   ENSP00000357544  

    CALY Human Recombinant Protein Products:

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    Novus Biologicals CALY Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for CALY

     
    Search eBioscience for Proteins for CALY 

     
    antibodies-online proteins for CALY (3 products) 

     
    antibodies-online peptides for CALY

    CALY Antibody Products:

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    antibodies-online antibodies for CALY (25 products) 

    CALY Assay Products:

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    Cloud-Clone Corp. ELISAs for CALY
    Cloud-Clone Corp. CLIAs for CALY
    Search eBioscience for ELISAs for CALY 
    antibodies-online kits for CALY (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009431 Calcyon_neuron-sp

    Graphical View of Domain Structure for InterPro Entry Q9NYX4

    ProtoNet protein and cluster: Q9NYX4

    1 Blocks protein domain: IPB009431 D1 dopamine receptor-interacting

    UniProtKB/Swiss-Prot: CALY_HUMAN, Q9NYX4
    Similarity: Belongs to the NSG family


    Find genes that share domains with CALY           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CALY_HUMAN, Q9NYX4
    Function: Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated
    endocytosis

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032051clathrin light chain binding IDA16595675
    GO:0032403protein complex binding IEA--
         
    Find genes that share ontologies with CALY           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CALY:
     Proliferating cells 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Caly):
     nervous system  normal 

    Find genes that share phenotypes with CALY           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Calytm1.1Cber for CALY

       genOway: Develop your customized and physiologically relevant rodent model for CALY

    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CALY

    Gene Editing
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    OriGene ORF clones in mouse, rat for CALY
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    GenScript: all cDNA clones in your preferred vector: CALY (NM_015722)
    Sino Biological Human cDNA Clone for CALY
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALY
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALY

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALY


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CALY_HUMAN, Q9NYX4: Cytoplasmic vesicle membrane; Single-pass membrane protein. Cell membrane; Single-pass
    membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    extracellular1
    golgi apparatus1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane IDA14534309
    GO:0016021integral component of membrane ----
    GO:0030659cytoplasmic vesicle membrane IEA--
    GO:0031410cytoplasmic vesicle IDA14534309

    Find genes that share ontologies with CALY           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CALY About    
    See pathways by source

    SuperPathContained pathways About
    1Circadian entrainment
    Dopaminergic synapse0.37


    Find genes that share SuperPaths with CALY           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for CALY):
        Dopaminergic synapse

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CALY
    Interactions:

        GeneGlobe Interaction Network for CALY

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for CALY (Q9NYX43 ENSP000002529394) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DRD1P217283I2D: score=2 
    DRD5ENSP000003061294STRING: ENSP00000306129
    --ENSP000003276524STRING: ENSP00000327652
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis IEA--
    GO:0007212dopamine receptor signaling pathway IEA--
    GO:0045807positive regulation of endocytosis IMP16595675
    GO:0048268clathrin coat assembly IDA16595675

    Find genes that share ontologies with CALY           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CALY

    2 HMDB Compounds for CALY    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Dopamine2-(3,4-Dihydroxyphenyl)ethylamine (see all 22)62-31-7--

    3 DrugBank Compounds for CALY    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    TrifluoperazineTrifluoperazin (see all 13)117-89-5targetantagonist945467 11752352 17407813
    ApomorphineApomorfin (see all 9)41372-20-7targetagonist11752352
    Clozapine-- 5786-21-0targetunknown11752352

    1 Novoseek inferred chemical compound relationship for CALY gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 12.6 1 16172615 (1)



    Find genes that share compounds with CALY           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CALY gene: 
    NM_015722.3  

    Unigene Cluster for CALY:

    Calcyon neuron-specific vesicular protein
    Hs.148680  [show with all ESTs]
    Unigene Representative Sequence: BM808864
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000252939(uc001lmo.2) ENST00000467433 ENST00000467611 ENST00000368558
    ENST00000368555 ENST00000368556
    miRNA
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CALY
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CALY
      QuantiTect SYBR Green Assays in human, mouse, rat CALY
      QuantiFast Probe-based Assays in human, mouse, rat CALY

    Additional mRNA sequence: 

    AF225903.1 BC038978.1 

    5 DOTS entries:

    DT.435605  DT.97861824  DT.75132223  DT.95152987  DT.95145204 

    Selected AceView cDNA sequences (see all 77):

    R89656 BM311840 BM054860 BQ776918 AW137855 BM311252 BM696026 AI197769 
    CR606939 BM053073 AI203942 BM713360 BM695916 CD107799 BM673540 BM503261 
    BI757112 BM728148 AI475073 BC038978 BQ787629 BI822293 BQ776602 BM666985 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CALY    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7
    SP1:                                      -           -     -                     
    SP2:                                      -                                       
    SP3:                                      -                                       
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for CALY

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CALY expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACAAGGCCA
    CALY Expression
    About this image


    CALY expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             Zeugopod Long Bone
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
             Ventral/hypothalamic-like neurons
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
             Ventral/hypothalamic-like neurons
     
     Limb (Muscoskeletal System)
             Pelvic Girdle
     
     Cartilage (Muscoskeletal System)
             Meckel's Cartilage
    CALY Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CALY Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.148680

    UniProtKB/Swiss-Prot: CALY_HUMAN, Q9NYX4
    Tissue specificity: Expressed in the pyramidal cells of the prefrontal cortex, in hippothalamus and in caudate
    nucleus. No expression in spleen. Up-regulated in the prefrontal cortex of schizophrenic patients with nearly
    twice the levels of non-schizophrenics

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALY

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for CALY gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Caly1 , 5 calcyon neuron-specific vesicular protein1, 5 85.74(n)1
    88.33(a)1
      7 (85.07 cM)5
    685661  NM_026769.51  NP_081045.21 
     1400698805 


    ENSEMBL Gene Tree for CALY (if available)
    TreeFam Gene Tree for CALY (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CALY gene
    HMP192  NSG12  
    4 SIMAP similar genes for CALY using alignment to 1 protein entry:     CALY_HUMAN:
    HMP19    D4S234E    NSG1    NSG2

    Find genes that share paralogs with CALY           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CALY (see all 357)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1848257071,2
    --135138497(+) TAGGAA/GGCAGG 1 -- ds50010--------
    rs1439100731,2
    --135138579(+) CCGGGG/TCCCAG 1 -- ds50010--------
    rs1896364631,2
    --135138678(+) CTGGGG/TGGGCC 1 -- ds50010--------
    rs1172642501,2
    C,F--135138868(+) CTGGCG/CGGGTG 1 -- ds50011Minor allele frequency- C:0.08EA 120
    rs1176977281,2
    C,F--135138870(+) GGCGGG/CGTGGG 1 -- ds50011Minor allele frequency- C:0.08EA 120
    rs1472547161,2
    C--135139181(+) TTCTGA/GCGGGC 1 -- int10--------
    rs1808498481,2
    --135139248(+) GGCGGA/GAGGCC 1 -- int10--------
    rs1406914521,2
    C--135139396(+) CTTGGC/TCGACG 2 T A mis10--------
    rs1497647821,2
    C,F--135139570(+) GCGCTC/TGGGGT 2 K E mis12Minor allele frequency- T:0.00NA EU 3521
    rs22757231,2
    C,F,A,H--135139635(+) GGAGGG/AGCCGG 1 -- int1 ese320Minor allele frequency- A:0.10EA NS NA WA EU 4133

    HapMap Linkage Disequilibrium report for CALY (135138927 - 135150475 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CALY (see all 27):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2e196CNV Duplication17116639
    dgv3e196CNV Duplication17116639
    nsv467509CNV Loss19166990
    nsv832036CNV Loss17160897
    dgv879n71CNV Loss21882294
    nsv896310CNV Loss21882294
    nsv896258CNV Loss21882294
    dgv882n71CNV Loss21882294
    dgv880n71CNV Loss21882294
    nsv896182CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CALY
    DNA2.0 Custom Variant and Variant Library Synthesis for CALY

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604647    OMIM disorders: --

    1 disease for CALY:    
    About MalaCards
    schizophrenia

    2 diseases from the University of Copenhagen DISEASES database for CALY:
    Attention deficit hyperactivity disorder     Schizophrenia

    Find genes that share disorders with CALY           About GenesLikeMe

    2 Novoseek inferred disease relationships for CALY gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcyon 98.4 6 16172615 (2), 12622665 (2), 14755439 (1), 10698743 (1)
    schizophrenia 34.3 2 12622665 (2)

    Genetic Association Database (GAD): CALY
    Human Genome Epidemiology (HuGE) Navigator: CALY (1 document)

    Export disorders for CALY gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CALY gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with CALY)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Dual signaling regulated by calcyon, a D1 dopamine receptor interacting protein. (PubMed id 10698743)2, 3, 9 Lezcano N....Bergson C. (Science 2000)
    2. Candidate gene analysis in an on-going genome-wide association study of attention-deficit hyperactivity disorder: suggestive association signals in ADRA1A. (PubMed id 19352218)1, 4 Elia J....Hakonarson H. (Psychiatr. Genet. 2009)
    3. Calcyon mRNA expression in the frontal-striatal circuitry and its relationship to vesicular processes and ADHD. (PubMed id 17623072)1, 3 Heijtz R.D....Castellanos F.X. (Behav Brain Funct 2007)
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    5. Calcyon, a novel partner of clathrin light chain, stimulates clathrin-mediated endocytosis. (PubMed id 16595675)1, 2 Xiao J.... Bergson C. (J. Biol. Chem. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Elevated intracellular calcium triggers recruitment of the receptor cross-talk accessory protein calcyon to the plasma membrane. (PubMed id 14534309)1, 2 Ali M.K. and Bergson C. (J. Biol. Chem. 2003)
    8. Association of the calcyon gene (DRD1IP) with attention deficit/hyperactivity disorder. (PubMed id 16172615)1, 9 Laurin N....Barr C.L. (Mol. Psychiatry 2005)
    9. Up-regulation of the D1 dopamine receptor-interacting protein, calcyon, in patients with schizophrenia. (PubMed id 12622665)2, 9 Koh P.O.... Lidow M.S. (Arch. Gen. Psychiatry 2003)
    10. CALCYON gene variation, schizophrenia, and cocaine dependence. (PubMed id 14755439)1, 9 Luo X....Gelernter J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 50632 HGNC: 17938 AceView: DRD1IP Ensembl:ENSG00000130643 euGenes: HUgn50632
    ECgene: CALY Kegg: 50632 H-InvDB: CALY

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CALY Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CALY gene:
    Search GeneIP for patents involving CALY

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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