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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CALY Gene

protein-coding   GIFtS: 58
GCID: GC10M135138

Calcyon Neuron-Specific Vesicular Protein

(Previous name: dopamine receptor D1 interacting protein)
(Previous symbol: DRD1IP)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Calcyon Neuron-Specific Vesicular Protein1 2     Calcyon D1 Dopamine Receptor-Interacting Protein (CALCYON)2
DRD1IP1 2 3     Calcyon Protein2
Dopamine Receptor D1 Interacting Protein1 2     D1 Dopamine Receptor-Interacting Protein2
NSG32     Neuron-Specific Vesicular Protein Calcyon2

External Ids:    HGNC: 179381   Entrez Gene: 506322   Ensembl: ENSG000001306437   OMIM: 6046475   UniProtKB: Q9NYX43   

Export aliases for CALY gene to outside databases

Previous GC identifers: GC10M134989 GC10M128683


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CALY Gene:
The protein encoded by this gene is a type II single transmembrane protein. It is required for maximal stimulated
calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. The encoded
protein interacts with D1 dopamine receptor and may interact with other DA receptor subtypes and/or GPCRs.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CALY Gene: 
CALY (calcyon neuron-specific vesicular protein) is a protein-coding gene. Diseases associated with CALY include juvenile astrocytoma, and cocaine dependence, and among its related super-pathways are Circadian entrainment. GO annotations related to this gene include clathrin light chain binding and dopamine receptor binding. An important paralog of this gene is HMP19.

UniProtKB/Swiss-Prot: CALY_HUMAN, Q9NYX4
Function: Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated
endocytosis

Gene Wiki entry for CALY (DRD1IP) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_008818.16  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CALY gene promoter:
         Elk-1   RFX1   HOXA3   Pax-5   MyoD   GATA-2   GATA-1   deltaCREB   Zic1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCALY promoter sequence
   Search SABiosciences Chromatin IP Primers for CALY

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CALY


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.3   Ensembl cytogenetic band:  10q26.3   HGNC cytogenetic band: 10q26.3

CALY Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALY gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M135138:  view genomic region     (about GC identifiers)

Start:
135,138,927 bp from pter      End:
135,150,475 bp from pter
Size:
11,549 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CALY_HUMAN, Q9NYX4 (See protein sequence)
Recommended Name: Neuron-specific vesicular protein calcyon  
Size: 217 amino acids; 23434 Da
Subunit: Interacts with CLTA
Subcellular location: Cytoplasmic vesicle membrane; Single-pass membrane protein. Cell membrane; Single-pass
membrane protein
Caution: Was originally (PubMed:10698743) thought to interact with the D1 dopamine receptor (DRD1) and to play a
role in potentiating calcium ion-dependent signaling but this work was later retracted
Caution: In cerebrospinal fluid (CSF), found to be O-glycosylated in the predicted intracellular region at Thr-180
and Thr-189 (PubMed:19838169). This glycosylation has been confirmed by a separate mass spectrometry (MS) method
(PubMed:23234360). Glycosylation in this region of the protein is unexplained as yet
Secondary accessions: Q5VWX3 Q5VWY5 Q5VWY6
Alternative splicing: 3 isoforms:  Q9NYX4-1   Q9NYX4-2   Q9NYX4-3   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for CALY: NX_Q9NYX4

Explore proteomics data for CALY at MOPED 

Post-translational modifications:

  • UniProtKB: Glycosylated (Probable)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NYX4

  • CALY Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CALY Protein Expression
    REFSEQ proteins: NP_056537.1  
    ENSEMBL proteins: 
     ENSP00000252939   ENSP00000357546   ENSP00000357543   ENSP00000357544  

    Human Recombinant Protein Products for CALY: 
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    OriGene Protein Over-expression Lysate for CALY
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    Novus Biologicals CALY Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CALY 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane IDA14534309
    GO:0016021integral to membrane ----
    GO:0030659cytoplasmic vesicle membrane IEA--
    GO:0031410cytoplasmic vesicle IDA14534309

    CALY for ontologies           About GeneDecksing



    CALY Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CALY
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    Novus Biologicals CALY Antibodies
    Abcam antibodies for CALY
    Cloud-Clone Corp. Antibodies for CALY 
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    Search LSBio for Antibodies for CALY 

    Assay Products for CALY: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CALY
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CALY 
    Cloud-Clone Corp. CLIAs for CALY


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009431 calcyon_neuron-sp

    Graphical View of Domain Structure for InterPro Entry Q9NYX4

    ProtoNet protein and cluster: Q9NYX4

    1 Blocks protein domain: IPB009431 D1 dopamine receptor-interacting

    UniProtKB/Swiss-Prot: CALY_HUMAN, Q9NYX4
    Similarity: Belongs to the NSG family


    CALY for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CALY_HUMAN, Q9NYX4
    Function: Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated
    endocytosis

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032051clathrin light chain binding IDA16595675
         
    CALY for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CALY:
     Proliferating cells 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Caly):
     nervous system  normal 

    CALY for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Calytm1.1Cber for CALY

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CALY 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CALY

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CALY 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CALY 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALY
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CALY
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CALY
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    Gene Editing
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    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CALY (see all 8)
    OriGene ORF clones in mouse, rat for CALY
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CALY (NM_015722)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALY
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALY
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                         Customized lentivirus expression plasmids for stable overexpression of CALY 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALY


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CALY About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Circadian entrainment
    Dopaminergic synapse0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for CALY):
        Dopaminergic synapse


    CALY for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CALY

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for CALY (Q9NYX43 ENSP000002529394) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DRD1P217283I2D: score=2 
    DRD5ENSP000003061294STRING: ENSP00000306129
    --ENSP000003276524STRING: ENSP00000327652
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis IEA--
    GO:0007212dopamine receptor signaling pathway IEA--
    GO:0045807positive regulation of endocytosis IMP16595675
    GO:0048268clathrin coat assembly IDA16595675

    CALY for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CALY for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CALY

    2 HMDB Compounds for CALY    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Dopamine2-(3,4-Dihydroxyphenyl)ethylamine (see all 22)62-31-7--

    3 DrugBank Compounds for CALY    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    TrifluoperazineTrifluoperazin (see all 13)117-89-5targetantagonist945467 11752352 17407813
    ApomorphineApomorfin (see all 9)41372-20-7targetagonist11752352
    Clozapine-- 5786-21-0targetunknown11752352

    1 Novoseek inferred chemical compound relationship for CALY gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 12.6 1 16172615 (1)

    Search CenterWatch for drugs/clinical trials and news about CALY

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CALY gene: 
    NM_015722.3  

    Unigene Cluster for CALY:

    Calcyon neuron-specific vesicular protein
    Hs.148680  [show with all ESTs]
    Unigene Representative Sequence: BM808864
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000252939(uc001lmo.2) ENST00000467433 ENST00000467611 ENST00000368558
    ENST00000368555 ENST00000368556

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALY
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CALY
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CALY
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALY
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALY
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                         Customized lentivirus expression plasmids for stable overexpression of CALY 
    Primer
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    OriGene qPCR primer pairs and template standards for CALY
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALY
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALY

    Additional mRNA sequence: 

    AF225903.1 BC038978.1 

    5 DOTS entries:

    DT.435605  DT.97861824  DT.75132223  DT.95152987  DT.95145204 

    24/77 AceView cDNA sequences (see all 77):

    CD107799 BI822293 CR606939 BQ776918 BM311840 BM503261 R89656 BM673540 
    AI475073 BM053073 BM311252 AW137855 AI197769 BM695916 BI757112 BM713360 
    AI203942 BQ776602 BM728148 BM054860 BM696026 BC038978 BQ787629 BM128248 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CALY    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7
    SP1:                                      -           -     -                     
    SP2:                                      -                                       
    SP3:                                      -                                       
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for CALY

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CALY expression in normal human tissues (normalized intensities)      CALY embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACAAGGCCA
    CALY Expression
    About this image


    CALY expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 10 entries
             Zeugopod Long Bone
             skeleton/pectoral girdle and thoracic body wall/scapula   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 6 entries
             Meckel's Cartilage
             sensory organ/nose/nasal septum   
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Pons
             Temporal Lobe   
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 3 entries
             skeleton/cranium/chondrocranium   
     
     Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem Z11, Meso Progenitor
             skeleton/axial skeleton   

    See CALY Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CALY

    SOURCE GeneReport for Unigene cluster: Hs.148680

    UniProtKB/Swiss-Prot: CALY_HUMAN, Q9NYX4
    Tissue specificity: Expressed in the pyramidal cells of the prefrontal cortex, in hippothalamus and in caudate
    nucleus. No expression in spleen. Up-regulated in the prefrontal cortex of schizophrenic patients with nearly
    twice the levels of non-schizophrenics

        SABiosciences Custom PCR Arrays for CALY
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALY

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for CALY gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Caly1 , 5 calcyon neuron-specific vesicular protein1, 5 81.71(n)1
    81.86(a)1
      7 (85.07 cM)5
    685661  NM_001190385.11  NP_001177314.11 
     1400698805 


    ENSEMBL Gene Tree for CALY (if available)
    TreeFam Gene Tree for CALY (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CALY gene
    HMP192  NSG12  
    4 SIMAP similar genes for CALY using alignment to 1 protein entry:     CALY_HUMAN:
    HMP19    D4S234E    NSG1    NSG2

    CALY for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/357 SNPs in CALY are shown (see all 357)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1848257071,2
    --135138497(+) TAGGAA/GGCAGG 1 -- ds50010--------
    rs1439100731,2
    --135138579(+) CCGGGG/TCCCAG 1 -- ds50010--------
    rs1896364631,2
    --135138678(+) CTGGGG/TGGGCC 1 -- ds50010--------
    rs1172642501,2
    C,F--135138868(+) CTGGCG/CGGGTG 1 -- ds50011Minor allele frequency- C:0.08EA 120
    rs1176977281,2
    C,F--135138870(+) GGCGGG/CGTGGG 1 -- ds50011Minor allele frequency- C:0.08EA 120
    rs1472547161,2
    C--135139181(+) TTCTGA/GCGGGC 1 -- int10--------
    rs1808498481,2
    --135139248(+) GGCGGA/GAGGCC 1 -- int10--------
    rs1406914521,2
    C--135139396(+) CTTGGC/TCGACG 2 T A mis10--------
    rs1497647821,2
    C,F--135139570(+) GCGCTC/TGGGGT 2 K E mis12Minor allele frequency- T:0.00NA EU 3521
    rs22757231,2
    C,F,A,H--135139635(+) GGAGGG/AGCCGG 1 -- int1 ese320Minor allele frequency- A:0.10EA NS NA WA EU 4133

    HapMap Linkage Disequilibrium report for CALY (135138927 - 135150475 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/27 variations for CALY (see all 27):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv2e196CNV Duplication17116639
    dgv3e196CNV Duplication17116639
    nsv467509CNV Loss19166990
    nsv832036CNV Loss17160897
    dgv879n71CNV Loss21882294
    nsv896310CNV Loss21882294
    nsv896258CNV Loss21882294
    dgv882n71CNV Loss21882294
    dgv880n71CNV Loss21882294
    nsv896182CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604647    OMIM disorders: --

    9 diseases for CALY:    About MalaCards
    juvenile astrocytoma    cocaine dependence    pilocytic astrocytoma    attention deficit hyperactivity disorder
    anorexia nervosa    astrocytoma    schizophrenia    neuronitis
    alzheimer's disease

    2 diseases from the University of Copenhagen DISEASES database for CALY:
    Attention deficit hyperactivity disorder     Schizophrenia

    CALY for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for CALY gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcyon 98.4 6 16172615 (2), 12622665 (2), 14755439 (1), 10698743 (1)
    schizophrenia 34.3 2 12622665 (2)

    Genetic Association Database (GAD): CALY
    Human Genome Epidemiology (HuGE) Navigator: CALY (1 document)

    Export disorders for CALY gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CALY gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with CALY)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Dual signaling regulated by calcyon, a D1 dopamine receptor interacting protein. (PubMed id 10698743)2, 3, 9 Lezcano N....Bergson C. (2000)
    2. Candidate gene analysis in an on-going genome-wide association study of attention-deficit hyperactivity disorder: suggestive association signals in ADRA1A. (PubMed id 19352218)1, 4 Elia J....Hakonarson H. (2009)
    3. Calcyon mRNA expression in the frontal-striatal circuitry and its relationship to vesicular processes and ADHD. (PubMed id 17623072)1, 3 Heijtz R.D....Castellanos F.X. (2007)
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    5. Calcyon, a novel partner of clathrin light chain, stimulates clathrin-mediated endocytosis. (PubMed id 16595675)1, 2 Xiao J.... Bergson C. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Elevated intracellular calcium triggers recruitment of the receptor cross-talk accessory protein calcyon to the plasma membrane. (PubMed id 14534309)1, 2 Ali M.K. and Bergson C. (2003)
    8. Association of the calcyon gene (DRD1IP) with attention deficit/hyperactivity disorder. (PubMed id 16172615)1, 9 Laurin N....Barr C.L. (2005)
    9. Up-regulation of the D1 dopamine receptor-interacting protein, calcyon, in patients with schizophrenia. (PubMed id 12622665)2, 9 Koh P.O....Lidow M.S. (2003)
    10. CALCYON gene variation, schizophrenia, and cocaine dependence. (PubMed id 14755439)1, 9 Luo X....Gelernter J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 50632 HGNC: 17938 AceView: DRD1IP Ensembl:ENSG00000130643 euGenes: HUgn50632
    ECgene: CALY Kegg: 50632 H-InvDB: CALY

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CALY Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CALY gene:
    Search GeneIP for patents involving CALY

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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