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Aliases & Descriptions for CALY
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases CALCYON 1 DRD1IP 2 , 3 NSG3 1 , 2 OTTHUMP00000020793 2
Descriptions D1 dopamine receptor-interacting protein 2 calcyon D1 dopamine receptor-interacting protein (CALCYON) 2 calcyon neuron-specific vesicular protein 2 calcyon protein 2 dopamine receptor D1 interacting protein 1 , 2
Search outside databases for aliases for CALY gene
Summaries for CALY (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for CALY : The protein encoded by this gene is a type II single transmembrane protein. It is required formaximal stimulated calcium release after stimulation of purinergic or muscarinic but notbeta-adrenergic receptors. The encoded protein interacts with D1 dopamine receptor and mayinteract with other DA receptor subtypes and/or GPCRs. [provided by RefSeq] UniProtKB/Swiss-Prot: CALY_HUMAN, Q9NYX4 Function : Interacts with clathrin light chain A and stimulates clathrin self-assembly andclathrin-mediated endocytosis
Gene Wiki entry for CALY (DRD1IP)
Genomic Location for CALY
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 10q26.3 Ensembl cytogenetic band: 10q26.3 HGNC cytogenetic band: 10q26.3 CALY Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure
GeneLoc location for GC10M134989:
(about GC identifiers )
Start:
134,988,922 bp from pter
End:
135,000,429 bp from pter
Size:
11,508 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000010.9 NT_017795.18 Proteins for CALY
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: CALY_HUMAN, Q9NYX4 (See
protein sequence )Recommended Name: Neuron-specific vesicular protein calcyon Size : 217 amino acids; 23434 Da
Subunit : Interacts with CLTA
Subcellular location : Cytoplasmic vesicle membrane; Single-pass membrane protein. Cell membrane;Single-pass membrane protein
Caution : Was originally (PubMed:10698743) thought to interact with the D1 dopamine receptor (DRD1)and to play a role in potentiating calcium ion-dependent signaling but this work was laterretracted
Secondary accessions : Q5VWX3 Q5VWY5 Q5VWY6Alternative splicing : 3 isoforms : Q9NYX4-1 Q9NYX4-2 Q9NYX4-3
Post-translational modifications:
Glycosylated (Probable)1
REFSEQ proteins: NP_056537.1 ENSEMBL proteins: ENSP00000252939 ENSP00000357544 ENSP00000357546 ENSP00000357543 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 4 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for CALY: Assays for CALY:
Protein
Domains/ Families for CALY(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9NYX4 ProtoNet protein and cluster: Q9NYX4
1 Blocks protein family : IPB009431 D1 dopamine receptor-interacting UniProtKB/Swiss-Prot: CALY_HUMAN, Q9NYX4 Similarity : Belongs to the NSG family
Gene Function for CALY
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015722 Applied Biosystems Silencer ® siRNAs for CALY Sigma-Aldrich siRNA for CALY Sigma-Aldrich shRNA for CALY Explore Sigma-Aldrich super-pooled esiRNAs               OriGene GFP tagged cDNA clone in CMV expression vector: NM_015722                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015722                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_015722  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_015722 UniProtKB/Swiss-Prot: CALY_HUMAN, Q9NYX4 Function : Interacts with clathrin light chain A and stimulates clathrin self-assembly andclathrin-mediated endocytosis
2 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Caly) :2 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for CALY
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for CALY (Your Favorite Gene powered by Ingenuity) Gene Network CentralTM Interacting Genes and Proteins Network for CALY 3 Interacting proteins for CALY (ENSP00000252939 3 ) via UniProtKB, MINT, and/or STRING About this table 3 Gene Ontology (GO) biological process terms (links to tree view) :
About this table
Drugs & Compounds for CALY (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for CALY 1 Novoseek chemical compound relationship for CALY gene
Compound
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
calcium
13.31
1
16172615 (1)
About this table
Transcripts for CALY(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015722 Sigma-Aldrich siRNA for CALY Sigma-Aldrich shRNA for CALY Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_015722
REFSEQ mRNAs for CALY gene: NM_015722.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_015722
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015722                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015722                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_015722  
Additional cDNA sequence: AF225903.1 BC038978.1 CR606939.1
5 DOTS entries : DT.435605 DT.97861824 DT.75132223 DT.95152987 DT.95145204
24/77 AceView cDNA sequences (see all 77
):BQ776602 BM311252 R89656 AI475073 CR606939 BM695916 BM053073 AI203942 BC038978 BM696026 BQ787629 BI757112 AI197769 BM503261 BM673540 BM713360 CD107799 BI822293 AW137855 BQ776918 BM311840 BM054860 BM728148 AF225903
Unigene Cluster for CALY: Calcyon neuron-specific vesicular protein Hs.148680 [show with all ESTs ] Unigene Representative Sequence: BM808864 GeneLoc Exon Structure 5 Alternative Splicing Database (ASD) splice patterns (SP) for CALY ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 SP1 :             -     -   -         SP2 :             -               SP3 :             -               SP4 :                           SP5 :                          
About this scheme ECgene alternative splicing isoforms for CALY 4 Ensembl transcripts including schematic representations : ENST00000252939
ENST00000368556
ENST00000368558
ENST00000368555
Expression for CALY
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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CALY expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for CALY 1 / 2
3 probe-sets matching CALY gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TACAAGGCCASOURCE GeneReport for Unigene cluster: Hs.148680 UniProtKB/Swiss-Prot: CALY_HUMAN, Q9NYX4 Tissue specificity : Expressed in the pyramidal cells of the prefrontal cortex, in hippothalamus andin caudate nucleus. No expression in spleen. Up-regulated in the prefrontal cortex ofschizophrenic patients with nearly twice the levels of non-schizophrenics
Orthologs for CALY
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for CALY gene from 5 species
About this table Species with no ortholog for CALY ENSEMBL Gene Tree for CALY Paralogs for CALY (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for CALY gene HMP19 2 D4S234E 2
SNPs/Variants for CALY (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for CALY (up to first 250kb)
Disorders & Mutations for CALY
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 604647 2 Novoseek disease relationships for CALY gene
About this table Human Genome Epidemiology Navigator: CALY (0 documents)
Medical News for CALY (Possibly Related Articles in
Doctor's Guide )
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--
Publications for CALY (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/15 PubMed articles for CALY gene (see all 15
): Dual signaling regulated by calcyon, a D1 dopamine receptor interacting protein. (PubMed id 10698743) 1, 2, 3, 4 Lezcano N....Bergson C. (2000) Calcyon mRNA expression in the frontal-striatal circuitry and its relationship to vesicular processes and ADHD. (PubMed id 17623072) 2, 3 Heijtz R.D....Castellanos F.X. (2007) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 3, 4 Olsen J.V....Mann M. (2006) Calcyon, a novel partner of clathrin light chain, stimulates clathrin-mediated endocytosis. (PubMed id 16595675) 3, 4 Xiao J.... Bergson C. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Elevated intracellular calcium triggers recruitment of the receptor cross-talk accessory protein calcyon to the plasma membrane. (PubMed id 14534309) 3, 4 Ali M.K. and Bergson C. (2003) Association of the calcyon gene (DRD1IP) with attention deficit/hyperactivity disorder. (PubMed id 16172615) 1, 3 Laurin N....Barr C.L. (2005) Up-regulation of the D1 dopamine receptor-interacting protein, calcyon, in patients with schizophrenia. (PubMed id 12622665) 1, 4 Koh P.O....Lidow M.S. (2003) CALCYON gene variation, schizophrenia, and cocaine dependence. (PubMed id 14755439) 1, 3 Luo X....Gelernter J. (2004) Candidate gene analysis in an on-going genome-wide association study of attention-deficit hyperactivity disorder: suggestive association signals in ADRA1A. (PubMed id 19352218) 3 Elia J....Hakonarson H. (2009)
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Genome Databases showing CALY
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing CALY
(According to HUGE )
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Specialized Databases showing CALY (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for CALY (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for CALY:
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