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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CALY Gene

protein-coding   GIFtS: 55
GCID: GC10M135138

calcyon neuron-specific vesicular protein

(Previous name: dopamine receptor D1 interacting protein )
(Previous symbol: DRD1IP)
 Explore 11 diseases affiliated with
CALY via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CALY    

Aliases
for CALY gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Calcyon Neuron-Specific Vesicular Protein1 2     Calcyon D1 Dopamine Receptor-Interacting Protein (CALCYON)2
DRD1IP1 2 3     Calcyon Protein2
NSG31 2     D1 Dopamine Receptor-Interacting Protein2
Dopamine Receptor D1 Interacting Protein1 2     Neuron-Specific Vesicular Protein Calcyon2
CALCYON1     

External Ids:    HGNC: 179381   Entrez Gene: 506322   Ensembl: ENSG000001306437   OMIM: 6046475   UniProtKB: Q9NYX43   

Export aliases for CALY gene to outside databases

Previous GC identifers: GC10M134989 GC10M128683


Summaries
for CALY gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CALY:
The protein encoded by this gene is a type II single transmembrane protein. It is required for maximal stimulated
calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. The encoded protein
interacts with D1 dopamine receptor and may interact with other DA receptor subtypes and/or GPCRs. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CALY_HUMAN, Q9NYX4
Function: Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis

Gene Wiki entry for CALY (DRD1IP)


Genomic Views
for CALY gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_008818.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CALY gene promoter:
         Elk-1   RFX1   HOXA3   Pax-5   MyoD   GATA-2   GATA-1   deltaCREB   Zic1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CALY promoter sequence
   Search SABiosciences Chromatin IP Primers for CALY

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CALY


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.3   Ensembl cytogenetic band:  10q26.3   HGNC cytogenetic band: 10q26.3

CALY Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALY gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M135138:  view genomic region     (about GC identifiers)

Start:
 135,138,927 bp from pter      End:
 135,150,475 bp from pter
Size:
 11,549 bases      Orientation:
 minus strand

Proteins
for CALY gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CALY_HUMAN, Q9NYX4 (See protein sequence)
Recommended Name: Neuron-specific vesicular protein calcyon  
Size: 217 amino acids; 23434 Da
Subunit: Interacts with CLTA
Subcellular location: Cytoplasmic vesicle membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane
protein
Caution: Was originally (PubMed:10698743) thought to interact with the D1 dopamine receptor (DRD1) and to play a role
in potentiating calcium ion-dependent signaling but this work was later retracted
Caution: In cerebrospinal fluid (CSF), found to be O-glycosylated in the predicted intracellular region at Thr-180 and
Thr-189 (PubMed:19838169). This glycosylation has been confirmed by a separate mass spectrometry (MS) method
(PubMed:23234360). Glycosylation in this region of the protein is unexplained as yet
Secondary accessions: Q5VWX3 Q5VWY5 Q5VWY6
Alternative splicing: 3 isoforms:  Q9NYX4-1   Q9NYX4-2   Q9NYX4-3   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for CALY: NX_Q9NYX4

Post-translational modifications:

  • Glycosylated (Probable)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NYX4

    • CALY Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_056537.1  
    ENSEMBL proteins: 
     ENSP00000252939   ENSP00000357546   ENSP00000357543   ENSP00000357544  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: CALY
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CALY

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane IDA14534309
    GO:0030659cytoplasmic vesicle membrane IEA--
    GO:0031410cytoplasmic vesicle IDA16595675


    CALY for ontologies           About GeneDecksing



    CALY Antibody Products: 
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    Uscn Antibodies for CALY
    Search ThermoFisher Antibodies for CALY

    Assay Products for CALY: 
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    Uscn ELISAs and CLIAs for CALY

    Protein Domains /
    Families
    for CALY gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CALY for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR009431 D1-dopamine_rcpt_interact

    Graphical View of Domain Structure for InterPro Entry Q9NYX4

    ProtoNet protein and cluster: Q9NYX4

    1 Blocks protein family: IPB009431 D1 dopamine receptor-interacting

    UniProtKB/Swiss-Prot: CALY_HUMAN, Q9NYX4
    Similarity: Belongs to the NSG family


    Function
    for CALY gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CALY_HUMAN, Q9NYX4
    Function: Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALY
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CALY (see all 4)
    OriGene shRNA RFP: CALY
    OriGene siRNA: CALY
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALY

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CALY

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CALY (see all 5)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CALY (NM_015722)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALY
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALY 

    Cell Line
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    Search LifeMap BioReagents cell lines for CALY

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CALY

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032051clathrin light chain binding IDA16595675
    GO:0050780dopamine receptor binding IEA--


    CALY for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CALY:
     Proliferating cells 

    Animal Models:
         Mouse knock-out Calytm1.1Cber for CALY
         2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Caly):
     nervous system  normal 

    CALY for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CALY gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CALY

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CALY (Q9NYX43 ENSP000002529394) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DRD1P217283, ENSP000003276524I2D: score=2 STRING: ENSP00000327652
    DRD5ENSP000003061294STRING: ENSP00000306129
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis IEA--
    GO:0007212dopamine receptor signaling pathway IEA--
    GO:0045807positive regulation of endocytosis IMP16595675
    GO:0048268clathrin coat assembly IDA16595675


    CALY for ontologies           About GeneDecksing



    Drugs & Compounds
    for CALY gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CALY for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CALY

    2 HMDB Compounds for CALY    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Dopamine2-(3,4-Dihydroxyphenyl)ethylamine (see all 22)62-31-7--

    3 DrugBank Compounds for CALY    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    TrifluoperazineTrifluoperazin (see all 13)117-89-5targetantagonist945467 11752352 17407813
    ApomorphineApomorfin (see all 9)41372-20-7targetagonist11752352
    Clozapine-- 5786-21-0targetunknown11752352

    1 Novoseek chemical compound relationship for CALY gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 12.6 1 16172615 (1)

    Search CenterWatch for drugs/clinical trials and news about CALY 

    Transcripts
    for CALY gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CALY gene: 
    NM_015722.3  

    Unigene Cluster for CALY:

    Calcyon neuron-specific vesicular protein
    Hs.148680  [show with all ESTs]
    Unigene Representative Sequence: BM808864
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000252939(uc001lmo.2) ENST00000467433 ENST00000467611 ENST00000368558
    ENST00000368555 ENST00000368556

    miRNA
    Products:             		 OriGene 3'-UTR Clone: CALY
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALY
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CALY
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CALY (see all 4)
    OriGene shRNA RFP: CALY
    OriGene siRNA: CALY
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALY
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CALY (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CALY (NM_015722)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALY
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALY 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALY
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALY

    Additional cDNA sequence: 

    AF225903.1 BC038978.1 

    5 DOTS entries:

    DT.435605  DT.97861824  DT.75132223  DT.95152987  DT.95145204 

    24/77 AceView cDNA sequences (see all 77):

    BQ776918 BM311252 BC038978 BM673540 BI757112 BQ776602 BM054860 BM696026 
    AW137855 BQ787629 BM728148 BM695916 AI203942 BM311840 R89656 BM713360 
    BM503261 AI197769 BI822293 AI475073 CR606939 BM053073 CD107799 AV708472 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CALY    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7
    SP1:                                      -           -     -                     
    SP2:                                      -                                       
    SP3:                                      -                                       
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for CALY

    Expression
    for CALY gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CALY expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACAAGGCCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CALY expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    9 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerGABAergic Amacrine CellsAmacrine, Retina
    Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
    BoneAutopod Long BoneBone
    BoneEndochondral Facial BonesBone
    BoneStylopod Long BoneBone
    BoneThoracic RibBone
    BoneZeugopod Long BoneBone
    CartilageMeckel's CartilageCartilage
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    Ventral/hypothalamic-like neurons (Generation of midbra...)

    See CALY Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CALY

    SOURCE GeneReport for Unigene cluster: Hs.148680

    UniProtKB/Swiss-Prot: CALY_HUMAN, Q9NYX4
    Tissue specificity: Expressed in the pyramidal cells of the prefrontal cortex, in hippothalamus and in caudate nucleus.
    No expression in spleen. Up-regulated in the prefrontal cortex of schizophrenic patients with nearly twice the levels
    of non-schizophrenics

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    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CALY

    Orthologs
    for CALY gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CALY gene from 1/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    zebrafish
    (Danio rerio)    		 Actinopterygii caly6
    		 calcyon neuron-specific vesicular protein
    		 39(a)
    		 1 ↔ 1
    		 1(49773285-49802847)


    ENSEMBL Gene Tree for CALY (if available)
    TreeFam Gene Tree for CALY (if available) 

    Paralogs
    for CALY gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CALY gene
    HMP192  NSG12  
    4 SIMAP similar genes for CALY using alignment to 1 protein entry:     CALY_HUMAN:
    HMP19    D4S234E    NSG1    NSG2

    CALY for paralogs           About GeneDecksing



    Genomic Variants
    for CALY gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/265 NCBI SNPs in CALY are shown (see all 265)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1848257071,2
    		--135138497(+) TAGGAA/GGCAGG 1 -- ds50010--------
    rs1439100731,2
    		--135138579(+) CCGGGG/TCCCAG 1 -- ds50010--------
    rs1896364631,2
    		--135138678(+) CTGGGG/TGGGCC 1 -- ds50010--------
    rs1172642501,2
    		F,--135138868(+) CTGGCG/CGGGTG 1 -- ds50011Minor allele frequency- C:0.08EA 120
    rs1176977281,2
    		F,--135138870(+) GGCGGG/CGTGGG 1 -- ds50011Minor allele frequency- C:0.08EA 120
    rs1472547161,2
    		C,--135139181(+) TTCTGA/GCGGGC 1 -- int10--------
    rs1808498481,2
    		--135139248(+) GGCGGA/GAGGCC 1 -- int10--------
    rs1406914521,2
    		--135139396(+) CTTGGC/TCGACG 2 T A mis10--------
    rs1497647821,2
    		C,F,--135139570(+) GCGCTC/TGGGGT 2 K E mis12Minor allele frequency- T:0.00NA EU 3521
    rs22757231,2
    		C,F,A,H,--135139635(+) GGAGGG/AGCCGG 1 -- int1 ese320Minor allele frequency- A:0.10EA NS NA WA EU 4133

    HapMap Linkage Disequilibrium report for CALY (135138927 - 135150475 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 16 variations for CALY
         14 CNVs: 29878 2896 29877 30526 5270 4721 8673 5272 5269 5273 3829 53744 5271 4724
         2 Indels: 75451 85554

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CALY
    DNA2.0 Custom Variant and Variant Library Synthesis for CALY

    Disorders / Diseases
    for CALY gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CALY for disorders           About GeneDecksing

    OMIM gene information: 604647    OMIM disorders: --

    11 diseases for CALY:    About MalaCards
    attention deficit hyperactivity disorder    neuronitis    cocaine dependence    pilocytic astrocytoma
    anorexia nervosa    juvenile astrocytoma    adhd    astrocytoma
    alzheimer's disease    schizophrenia    cholesterol

    1 disease from the University of Copenhagen DISEASES database for CALY:
    Pilocytic astrocytoma

    2 Novoseek disease relationships for CALY gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcyon 98.4 6 16172615 (2), 12622665 (2), 14755439 (1), 10698743 (1)
    schizophrenia 34.3 2 12622665 (2)

    Human Genome Epidemiology (HuGE) Navigator: CALY (1 document)

    Export disorders for CALY gene to outside databases

    Publications
    for CALY gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CALY gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with CALY)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Dual signaling regulated by calcyon, a D1 dopamine receptor interacting protein. (PubMed id 10698743)2, 3, 9 Lezcano N....Bergson C. (2000)
    2. Calcyon mRNA expression in the frontal-striatal circuitry and its relationship to vesicular processes and ADHD. (PubMed id 17623072)1, 3 Heijtz R.D....Castellanos F.X. (2007)
    3. Calcyon, a novel partner of clathrin light chain, stimulates clathrin-mediated endocytosis. (PubMed id 16595675)1, 2 Xiao J.... Bergson C. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Elevated intracellular calcium triggers recruitment of the receptor cross-talk accessory protein calcyon to the plasma membrane. (PubMed id 14534309)1, 2 Ali M.K. and Bergson C. (2003)
    6. Association of the calcyon gene (DRD1IP) with attention deficit/hyperactivity disorder. (PubMed id 16172615)1, 9 Laurin N....Barr C.L. (2005)
    7. Up-regulation of the D1 dopamine receptor-interacting protein, calcyon, in patients with schizophrenia. (PubMed id 12622665)2, 9 Koh P.O....Lidow M.S. (2003)
    8. CALCYON gene variation, schizophrenia, and cocaine dependence. (PubMed id 14755439)1, 9 Luo X....Gelernter J. (2004)
    9. LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins. (PubMed id 23234360)2 Halim A.... Nilsson J. (2013)
    10. Calcyon forms a novel ternary complex with dopamine D1 receptor through PSD-95 protein and plays a role in dopamine receptor internali zation. (PubMed id 22843680)1 Ha C.M....Chang S. (2012)

    External Searches for CALY gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CALY gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 50632 HGNC: 17938 AceView: DRD1IP Ensembl:ENSG00000130643 euGenes: HUgn50632
    ECgene: CALY H-InvDB: CALY

    Other Databases showing CALY gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CALY gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CALY Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CALY gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CALY gene:
    Search GeneIP for patents involving CALY

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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