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Aliases for CALY Gene

Aliases for CALY Gene

  • Calcyon Neuron Specific Vesicular Protein 2 3
  • Calcyon Neuron-Specific Vesicular Protein 2 3 5
  • Dopamine Receptor D1 Interacting Protein 2 3
  • DRD1IP 3 4
  • Calcyon D1 Dopamine Receptor-Interacting Protein (CALCYON) 3
  • D1 Dopamine Receptor-Interacting Protein 3
  • Calcyon Protein 3
  • NSG3 3

External Ids for CALY Gene

Previous HGNC Symbols for CALY Gene

  • DRD1IP

Previous GeneCards Identifiers for CALY Gene

  • GC10M134989
  • GC10M135138
  • GC10M128683

Summaries for CALY Gene

Entrez Gene Summary for CALY Gene

  • The protein encoded by this gene is a type II single transmembrane protein. It is required for maximal stimulated calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. The encoded protein interacts with D1 dopamine receptor and may interact with other DA receptor subtypes and/or GPCRs. [provided by RefSeq, Jul 2008]

GeneCards Summary for CALY Gene

CALY (Calcyon Neuron Specific Vesicular Protein) is a Protein Coding gene. Diseases associated with CALY include Attention Deficit-Hyperactivity Disorder and Schizophrenia. Among its related pathways are Circadian entrainment. GO annotations related to this gene include protein complex binding and clathrin light chain binding. An important paralog of this gene is HMP19.

UniProtKB/Swiss-Prot for CALY Gene

  • Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis.

Gene Wiki entry for CALY Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALY Gene

Genomics for CALY Gene

Regulatory Elements for CALY Gene

Enhancers for CALY Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CALY on UCSC Golden Path with GeneCards custom track

Genomic Location for CALY Gene

133,324,072 bp from pter
133,336,971 bp from pter
12,900 bases
Minus strand

Genomic View for CALY Gene

Genes around CALY on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALY Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALY Gene

Proteins for CALY Gene

  • Protein details for CALY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuron-specific vesicular protein calcyon
    Protein Accession:
    Secondary Accessions:
    • Q5VWX3
    • Q5VWY5
    • Q5VWY6

    Protein attributes for CALY Gene

    217 amino acids
    Molecular mass:
    23434 Da
    Quaternary structure:
    • Interacts with CLTA.

    Alternative splice isoforms for CALY Gene


neXtProt entry for CALY Gene

Proteomics data for CALY Gene at MOPED

Post-translational modifications for CALY Gene

Other Protein References for CALY Gene

Antibody Products

No data available for DME Specific Peptides for CALY Gene

Domains & Families for CALY Gene

Protein Domains for CALY Gene

Suggested Antigen Peptide Sequences for CALY Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NSG family.
  • Belongs to the NSG family.
genes like me logo Genes that share domains with CALY: view

No data available for Gene Families for CALY Gene

Function for CALY Gene

Molecular function for CALY Gene

UniProtKB/Swiss-Prot Function:
Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis.
genes like me logo Genes that share phenotypes with CALY: view

Animal Models for CALY Gene

MGI Knock Outs for CALY:

Animal Model Products

miRNA for CALY Gene

miRTarBase miRNAs that target CALY

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CALY Gene

Localization for CALY Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALY Gene

Cytoplasmic vesicle membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CALY Gene COMPARTMENTS Subcellular localization image for CALY gene
Compartment Confidence
plasma membrane 5
cytosol 1
extracellular 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CALY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IDA 14534309
genes like me logo Genes that share ontologies with CALY: view

Pathways & Interactions for CALY Gene

SuperPathways for CALY Gene

Superpath Contained pathways
1 Circadian entrainment
genes like me logo Genes that share pathways with CALY: view

Pathways by source for CALY Gene

1 KEGG pathway for CALY Gene

Interacting Proteins for CALY Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000252939 Q9NYX4-CALY_HUMAN for CALY Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for CALY Gene


No data available for SIGNOR curated interactions for CALY Gene

Drugs & Compounds for CALY Gene

(7) Drugs for CALY Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Apomorphine Approved, Investigational Pharma Partial agonist, Agonist, agonist, Target 34
Trifluoperazine Approved Pharma Antagonist, inhibitor, Target, antagonist 5
Clozapine Approved Pharma Antagonist, Target, unknown Antipsychotic medication, Dopamine antagonist with some D4 selectivity. Also 5-HT2A/2C antagonist 113
Dopamine Approved Pharma Full agonist, Agonist 3636
ADX-10061 Investigational Pharma Target 0
genes like me logo Genes that share compounds with CALY: view

Transcripts for CALY Gene

Unigene Clusters for CALY Gene

Calcyon neuron-specific vesicular protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CALY Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7
SP1: - - -
SP2: -
SP3: -

Relevant External Links for CALY Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CALY Gene

mRNA expression in normal human tissues for CALY Gene

mRNA differential expression in normal tissues according to GTEx for CALY Gene

This gene is overexpressed in Brain - Hypothalamus (x9.4), Pituitary (x5.8), Brain - Nucleus accumbens (basal ganglia) (x4.9), Brain - Frontal Cortex (BA9) (x4.1), and Brain - Cortex (x4.1).

Protein differential expression in normal tissues from HIPED for CALY Gene

This gene is overexpressed in Cerebrospinal fluid (44.3) and Plasma (21.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CALY Gene

SOURCE GeneReport for Unigene cluster for CALY Gene Hs.148680

mRNA Expression by UniProt/SwissProt for CALY Gene

Tissue specificity: Expressed in the pyramidal cells of the prefrontal cortex, in hippothalamus and in caudate nucleus. No expression in spleen. Up-regulated in the prefrontal cortex of schizophrenic patients with nearly twice the levels of non-schizophrenics.
genes like me logo Genes that share expression patterns with CALY: view

Protein tissue co-expression partners for CALY Gene

Primer Products

Orthologs for CALY Gene

This gene was present in the common ancestor of mammals.

Orthologs for CALY Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CALY 35
  • 79.3 (n)
  • 68.25 (a)
  • 62 (a)
(Canis familiaris)
Mammalia CALY 35
  • 89.32 (n)
  • 88.83 (a)
  • 82 (a)
(Mus musculus)
Mammalia Caly 35
  • 85.74 (n)
  • 88.33 (a)
Caly 16
Caly 36
  • 77 (a)
(Pan troglodytes)
Mammalia CALY 35
  • 99.15 (n)
  • 98.98 (a)
  • 97 (a)
(Rattus norvegicus)
Mammalia Caly 35
  • 85.13 (n)
  • 87.69 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 37 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 36 (a)
Species with no ortholog for CALY:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CALY Gene

Gene Tree for CALY (if available)
Gene Tree for CALY (if available)

Paralogs for CALY Gene

Paralogs for CALY Gene

(4) SIMAP similar genes for CALY Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CALY: view

Variants for CALY Gene

Sequence variations from dbSNP and Humsavar for CALY Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs3810958 -- 133,336,528(-) GGCAC(A/C/G)AGGAT intron-variant, upstream-variant-2KB
rs3909035 -- 133,325,656(-) GGGGG(G/T)TGCGA intron-variant, downstream-variant-500B
rs3909036 -- 133,325,646(-) AATCC(C/G)AGCCC intron-variant, downstream-variant-500B
rs2275723 -- 133,326,131(+) GGAGG(A/G)GCCGG intron-variant, downstream-variant-500B, utr-variant-3-prime
rs2298122 -- 133,328,068(+) CAAGA(G/T)AGCCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CALY Gene

Variant ID Type Subtype PubMed ID
nsv896182 CNV Loss 21882294
dgv856n71 CNV Loss 21882294
nsv528260 CNV Loss 19592680
dgv328e1 CNV Complex 17122850
nsv896258 CNV Loss 21882294
nsv832036 CNV Loss 17160897
dgv879n71 CNV Loss 21882294
dgv880n71 CNV Loss 21882294
nsv470980 CNV Loss 18288195
dgv2e196 CNV Duplication 17116639
dgv882n71 CNV Loss 21882294
essv9566 CNV CNV 17122850
dgv883n71 CNV Loss 21882294
dgv886n71 CNV Gain 21882294
dgv887n71 CNV Gain 21882294
essv20368 CNV CNV 17122850
nsv428243 CNV Gain 18775914
dgv122n27 CNV Loss 19166990
nsv896310 CNV Loss 21882294
dgv3e196 CNV Duplication 17116639
esv2750853 CNV Gain 17911159
dgv889n71 CNV Loss 21882294
nsv896314 CNV Gain 21882294
nsv832040 CNV Loss 17160897
nsv467509 CNV Loss 19166990
nsv8751 CNV Gain 18304495
nsv825672 CNV Gain 20364138

Variation tolerance for CALY Gene

Gene Damage Index Score: 2.90; 48.69% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CALY Gene

Disorders for CALY Gene

MalaCards: The human disease database

(2) MalaCards diseases for CALY Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
attention deficit-hyperactivity disorder
  • attention deficit hyperactivity disorder
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search CALY in MalaCards View complete list of genes associated with diseases

Relevant External Links for CALY

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CALY: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CALY Gene

Publications for CALY Gene

  1. Dual signaling regulated by calcyon, a D1 dopamine receptor interacting protein. (PMID: 10698743) Lezcano N. … Bergson C. (Science 2000) 2 4 23 67
  2. Calcyon mRNA expression in the frontal-striatal circuitry and its relationship to vesicular processes and ADHD. (PMID: 17623072) Heijtz R.D. … Castellanos F.X. (Behav Brain Funct 2007) 2 3
  3. Synthesis and antitubercular activity of phenothiazines with reduced binding to dopamine and serotonin receptors. (PMID: 17407813) Madrid P.B. … Tanga M.J. (Bioorg. Med. Chem. Lett. 2007) 25 26
  4. Association of the calcyon gene (DRD1IP) with attention deficit/hyperactivity disorder. (PMID: 16172615) Laurin N. … Barr C.L. (Mol. Psychiatry 2005) 3 23
  5. CALCYON gene variation, schizophrenia, and cocaine dependence. (PMID: 14755439) Luo X. … Gelernter J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2004) 3 23

Products for CALY Gene

Sources for CALY Gene