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Aliases for CALU Gene

Aliases for CALU Gene

  • Calumenin 2 3 5
  • IEF SSP 9302 4
  • Crocalbin 4

External Ids for CALU Gene

Previous GeneCards Identifiers for CALU Gene

  • GC07P126856
  • GC07P127919
  • GC07P127933
  • GC07P127973
  • GC07P128166
  • GC07P128380
  • GC07P122740
  • GC07P128381
  • GC07P128438
  • GC07P128497

Summaries for CALU Gene

Entrez Gene Summary for CALU Gene

  • The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

GeneCards Summary for CALU Gene

CALU (Calumenin) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation and Warfarin Pathway, Pharmacodynamics. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is SDF4.

UniProtKB/Swiss-Prot for CALU Gene

  • Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity).

Gene Wiki entry for CALU Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALU Gene

Genomics for CALU Gene

Regulatory Elements for CALU Gene

Promoters for CALU Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CALU on UCSC Golden Path with GeneCards custom track

Genomic Location for CALU Gene

Chromosome:
7
Start:
128,739,292 bp from pter
End:
128,773,423 bp from pter
Size:
34,132 bases
Orientation:
Plus strand

Genomic View for CALU Gene

Genes around CALU on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALU Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALU Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALU Gene

Proteins for CALU Gene

neXtProt entry for CALU Gene

Proteomics data for CALU Gene at MOPED

Post-translational modifications for CALU Gene

  • Ubiquitination at Lys 84, Lys 94, Lys 98, Lys 114, Lys 255, and Lys 94
  • Glycosylation at Thr 60, Asn 131, and Ser 261
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CALU (CALU)

No data available for DME Specific Peptides for CALU Gene

Domains & Families for CALU Gene

Gene Families for CALU Gene

Protein Domains for CALU Gene

Graphical View of Domain Structure for InterPro Entry

O43852

UniProtKB/Swiss-Prot:

CALU_HUMAN :
  • Contains 6 EF-hand domains.
  • Belongs to the CREC family.
Domain:
  • Contains 6 EF-hand domains.
Family:
  • Belongs to the CREC family.
genes like me logo Genes that share domains with CALU: view

Function for CALU Gene

Molecular function for CALU Gene

GENATLAS Biochemistry:
calumenin CA++ binding proteins in the ER and Golgi apparatus,EF hand subfamily,ubiquitously expressed (heart,placenta,skeletal muscle)
UniProtKB/Swiss-Prot Function:
Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity).

Gene Ontology (GO) - Molecular Function for CALU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18688696
genes like me logo Genes that share ontologies with CALU: view
genes like me logo Genes that share phenotypes with CALU: view

Animal Model Products

miRNA for CALU Gene

miRTarBase miRNAs that target CALU

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CALU Gene

Localization for CALU Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALU Gene

Endoplasmic reticulum membrane. Golgi apparatus. Secreted. Melanosome. Sarcoplasmic reticulum lumen. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269 PubMed:12643545}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CALU Gene COMPARTMENTS Subcellular localization image for CALU gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
extracellular 4
cytoskeleton 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CALU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005788 endoplasmic reticulum lumen IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IDA 19946888
GO:0042470 melanosome IEA --
genes like me logo Genes that share ontologies with CALU: view

Pathways & Interactions for CALU Gene

genes like me logo Genes that share pathways with CALU: view

Pathways by source for CALU Gene

Gene Ontology (GO) - Biological Process for CALU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0014070 response to organic cyclic compound IEA --
GO:0030168 platelet activation TAS --
genes like me logo Genes that share ontologies with CALU: view

No data available for SIGNOR curated interactions for CALU Gene

Drugs & Compounds for CALU Gene

(2) Drugs for CALU Gene - From: Novoseek, PharmGKB, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Warfarin Approved Pharma 422
calcium Nutra 0
genes like me logo Genes that share compounds with CALU: view

Transcripts for CALU Gene

Unigene Clusters for CALU Gene

Calumenin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CALU Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - -
SP8: - -
SP9: - - - - - - - -
SP10: - - - - - - -
SP11: - - -
SP12:
SP13: - -

Relevant External Links for CALU Gene

GeneLoc Exon Structure for
CALU
ECgene alternative splicing isoforms for
CALU

Expression for CALU Gene

mRNA expression in normal human tissues for CALU Gene

Protein differential expression in normal tissues from HIPED for CALU Gene

This gene is overexpressed in Bone marrow stromal cell (20.7), Amniocyte (15.3), and Oral epithelium (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CALU Gene



SOURCE GeneReport for Unigene cluster for CALU Gene Hs.743262

mRNA Expression by UniProt/SwissProt for CALU Gene

O43852-CALU_HUMAN
Tissue specificity: Ubiquitously expressed. Expressed at high levels in heart, placenta and skeletal muscle, at lower levels in lung, kidney and pancreas and at very low levels in brain and liver.
genes like me logo Genes that share expression patterns with CALU: view

Protein tissue co-expression partners for CALU Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CALU Gene

Orthologs for CALU Gene

This gene was present in the common ancestor of animals.

Orthologs for CALU Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CALU 35
  • 100 (n)
  • 100 (a)
CALU 36
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CALU 36
  • 99 (a)
OneToOne
CALU 35
  • 88.68 (n)
  • 92.38 (a)
dog
(Canis familiaris)
Mammalia CALU 35
  • 89.42 (n)
  • 92.06 (a)
CALU 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Calu 16
Calu 36
  • 91 (a)
OneToOne
Calu 35
  • 87.94 (n)
  • 91.75 (a)
oppossum
(Monodelphis domestica)
Mammalia CALU 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CALU 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Calu 35
  • 86.24 (n)
  • 91.43 (a)
lizard
(Anolis carolinensis)
Reptilia CALU 36
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33451 35
tropical clawed frog
(Silurana tropicalis)
Amphibia calu 35
  • 79.05 (n)
  • 87.3 (a)
Str.11110 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.458 35
zebrafish
(Danio rerio)
Actinopterygii calua 36
  • 79 (a)
OneToOne
calua 35
  • 73.02 (n)
  • 78.1 (a)
zgc63741 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010392 35
  • 59.17 (n)
  • 59.93 (a)
fruit fly
(Drosophila melanogaster)
Insecta scf 36
  • 47 (a)
OneToMany
CG9112 37
  • 36 (a)
scf 37
  • 55 (a)
scf 35
  • 57.1 (n)
  • 51.94 (a)
worm
(Caenorhabditis elegans)
Secernentea calu-1 35
  • 54 (n)
  • 51.33 (a)
calu-1 36
  • 48 (a)
OneToMany
F08B6.3 37
  • 30 (a)
M03F4.7 37
  • 50 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10829 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
CSA.6945 36
  • 47 (a)
ManyToMany
Species with no ortholog for CALU:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CALU Gene

ENSEMBL:
Gene Tree for CALU (if available)
TreeFam:
Gene Tree for CALU (if available)

Paralogs for CALU Gene

Paralogs for CALU Gene

(3) SIMAP similar genes for CALU Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CALU: view

Variants for CALU Gene

Sequence variations from dbSNP and Humsavar for CALU Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs8597 -- 128,771,368(+) TAGCT(C/T)TCTTG nc-transcript-variant, utr-variant-3-prime
rs11653 -- 128,769,526(+) CCCTT(A/T)TATGA nc-transcript-variant, utr-variant-3-prime
rs186837 -- 128,755,159(-) ttaaa(A/T)ttttt intron-variant
rs109829 -- 128,753,896(-) TCTAG(C/T)GAAGA intron-variant
rs339043 -- 128,755,026(-) cagcc(C/T)AATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CALU Gene

Variant ID Type Subtype PubMed ID
esv2735137 CNV Deletion 23290073
esv2670312 CNV Deletion 23128226
nsv831125 CNV Loss 17160897

Variation tolerance for CALU Gene

Residual Variation Intolerance Score: 24.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.77; 83.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CALU Gene

HapMap Linkage Disequilibrium report
CALU

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALU Gene

Disorders for CALU Gene

Relevant External Links for CALU

Genetic Association Database (GAD)
CALU
Human Genome Epidemiology (HuGE) Navigator
CALU
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CALU

No disorders were found for CALU Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CALU Gene

Publications for CALU Gene

  1. Human calumenin gene (CALU): cDNA isolation and chromosomal mapping to 7q32. (PMID: 9598325) Yabe D. … Honjo T. (Genomics 1998) 2 3 4 23 67
  2. Genetic determinants of acenocoumarol and phenprocoumon maintenance dose requirements. (PMID: 20020283) Cadamuro J. … Oberkofler H. (Eur. J. Clin. Pharmacol. 2010) 3 23
  3. A polymorphism in the VKORC1 regulator calumenin predicts higher warfarin dose requirements in African Americans. (PMID: 20200517) Voora D. … Gage B.F. (Clin. Pharmacol. Ther. 2010) 3 23
  4. Calumenin but not reticulocalbin forms a Ca2+-dependent complex with thrombospondin-1. A potential role in haemostasis and thrombosis. (PMID: 18688696) Hansen G.A. … HonorAc B. (Mol. Cell. Biochem. 2009) 3 23
  5. Genetic determinants of warfarin dosing in the Han-Chinese population. (PMID: 19958090) Lee M.T. … Chen Y.T. (Pharmacogenomics 2009) 3 23

Products for CALU Gene

Sources for CALU Gene

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