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Aliases for CALU Gene

Aliases for CALU Gene

  • Calumenin 2 3
  • IEF SSP 9302 4
  • Crocalbin 4

External Ids for CALU Gene

Summaries for CALU Gene

Entrez Gene Summary for CALU Gene

  • The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

GeneCards Summary for CALU Gene

CALU (Calumenin) is a Protein Coding gene. Among its related pathways are Hemostasis and Hemostasis. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is RCN2.

UniProtKB/Swiss-Prot for CALU Gene

  • Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity).

Gene Wiki entry for CALU Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALU Gene

Genomics for CALU Gene

Genomic Location for CALU Gene

Start:
128,739,292 bp from pter
End:
128,773,423 bp from pter
Size:
34,132 bases
Orientation:
Plus strand

Genomic View for CALU Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CALU Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALU Gene

Proteins for CALU Gene

neXtProt entry for CALU Gene

Proteomics data for CALU Gene at MOPED

Post-translational modifications for CALU Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys84, Lys94, Lys98, Lys114, Lys255, and Lys94
  • Glycosylation at Thr60, Asn131, and Ser261

Other Protein References for CALU Gene

No data available for DME Specific Peptides for CALU Gene

Domains for CALU Gene

Gene Families for CALU Gene

HGNC:
  • EFHAND :EF-hand domain containing

Protein Domains for CALU Gene

UniProtKB/Swiss-Prot:

CALU_HUMAN
Domain:
  • Contains 6 EF-hand domains.:
    • O43852
Family:
  • Belongs to the CREC family.:
    • O43852
genes like me logo Genes that share domains with CALU: view

Function for CALU Gene

Molecular function for CALU Gene

GENATLAS Biochemistry: calumenin CA++ binding proteins in the ER and Golgi apparatus,EF hand subfamily,ubiquitously expressed (heart,placenta,skeletal muscle)
UniProtKB/Swiss-Prot Function: Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity).

Gene Ontology (GO) - Molecular Function for CALU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IDA 10094503
GO:0005515 protein binding IPI 18688696
genes like me logo Genes that share ontologies with CALU: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CALU Gene

Localization for CALU Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALU Gene

Endoplasmic reticulum lumen. Secreted. Melanosome. Sarcoplasmic reticulum lumen. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CALU Gene COMPARTMENTS Subcellular localization image for CALU gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
golgi apparatus 4
cytoskeleton 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CALU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005794 Golgi apparatus TAS 9218460
GO:0016020 membrane IDA 19946888
GO:0016529 sarcoplasmic reticulum --
genes like me logo Genes that share ontologies with CALU: view

Pathways for CALU Gene

genes like me logo Genes that share pathways with CALU: view

Pathways by source for CALU Gene

1 PharmGKB pathway for CALU Gene

Gene Ontology (GO) - Biological Process for CALU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0007596 blood coagulation TAS --
GO:0008150 biological_process ND --
GO:0030168 platelet activation TAS --
genes like me logo Genes that share ontologies with CALU: view

Compounds for CALU Gene

(1) HMDB Compounds for CALU Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(2) Novoseek inferred chemical compound relationships for CALU Gene

Compound -log(P) Hits PubMed IDs
warfarin 65.2 6
calcium 0 2

(1) PharmGKB related drug/compound annotations for CALU Gene

Drug/compound Annotation
warfarin CA
genes like me logo Genes that share compounds with CALU: view

Transcripts for CALU Gene

Unigene Clusters for CALU Gene

Calumenin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CALU Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - -
SP8: - -
SP9: - - - - - - - -
SP10: - - - - - - -
SP11: - - -
SP12:
SP13: - -

Relevant External Links for CALU Gene

GeneLoc Exon Structure for
CALU
ECgene alternative splicing isoforms for
CALU

Expression for CALU Gene

mRNA expression in normal human tissues for CALU Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CALU Gene

SOURCE GeneReport for Unigene cluster for CALU Gene Hs.743262

mRNA Expression by UniProt/SwissProt for CALU Gene

O43852-CALU_HUMAN
Tissue specificity: Ubiquitously expressed. Expressed at high levels in heart, placenta and skeletal muscle, at lower levels in lung, kidney and pancreas and at very low levels in brain and liver
genes like me logo Genes that share expressions with CALU: view

Orthologs for CALU Gene

This gene was present in the common ancestor of animals.

Orthologs for CALU Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CALU 36
  • 100 (n)
  • 100 (a)
CALU 37
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CALU 36
  • 88.68 (n)
  • 92.38 (a)
CALU 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CALU 36
  • 89.42 (n)
  • 92.06 (a)
CALU 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Calu 36
  • 87.94 (n)
  • 91.75 (a)
Calu 16
Calu 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CALU 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CALU 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Calu 36
  • 86.24 (n)
  • 91.43 (a)
lizard
(Anolis carolinensis)
Reptilia CALU 37
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33451 36
tropical clawed frog
(Silurana tropicalis)
Amphibia calu 36
  • 79.05 (n)
  • 87.3 (a)
Str.11110 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.458 36
zebrafish
(Danio rerio)
Actinopterygii calua 36
  • 73.02 (n)
  • 78.1 (a)
calua 37
  • 79 (a)
OneToOne
zgc63741 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010392 36
  • 59.17 (n)
  • 59.93 (a)
fruit fly
(Drosophila melanogaster)
Insecta scf 36
  • 57.1 (n)
  • 51.94 (a)
scf 37
  • 47 (a)
OneToMany
scf 38
  • 55 (a)
CG9112 38
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea calu-1 36
  • 54 (n)
  • 51.33 (a)
calu-1 37
  • 48 (a)
OneToMany
M03F4.7 38
  • 50 (a)
F08B6.3 38
  • 30 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10829 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 46 (a)
ManyToMany
-- 37
  • 57 (a)
ManyToMany
CSA.6945 37
  • 47 (a)
ManyToMany
Species with no ortholog for CALU:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CALU Gene

ENSEMBL:
Gene Tree for CALU (if available)
TreeFam:
Gene Tree for CALU (if available)

Paralogs for CALU Gene

Paralogs for CALU Gene

Selected SIMAP similar genes for CALU Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CALU: view

Variants for CALU Gene

Sequence variations from dbSNP and Humsavar for CALU Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs8597 -- 128,771,368(+) TAGCT(C/T)TCTTG utr-variant-3-prime, nc-transcript-variant
rs8899 -- 128,770,560(+) CTCTT(A/T)CCCTC utr-variant-3-prime, nc-transcript-variant
rs11653 -- 128,769,526(+) CCCTT(A/T)TATGA utr-variant-3-prime, nc-transcript-variant
rs12984 -- 128,770,268(+) TTTTT(A/T)CTTCT utr-variant-3-prime, nc-transcript-variant
rs109829 -- 128,753,896(-) TCTAG(C/T)GAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CALU Gene

Variant ID Type Subtype PubMed ID
esv2735137 CNV Deletion 23290073
esv2670312 CNV Deletion 23128226
nsv831125 CNV Loss 17160897

Relevant External Links for CALU Gene

HapMap Linkage Disequilibrium report
CALU

Disorders for CALU Gene

(2) Novoseek inferred disease relationships for CALU Gene

Disease -log(P) Hits PubMed IDs
thrombosis 14.9 2
tumors 0 1

Relevant External Links for CALU

Genetic Association Database (GAD)
CALU
Human Genome Epidemiology (HuGE) Navigator
CALU
genes like me logo Genes that share disorders with CALU: view

No data available for UniProtKB/Swiss-Prot for CALU Gene

Publications for CALU Gene

  1. Human calumenin gene (CALU): cDNA isolation and chromosomal mapping to 7q32. (PMID: 9598325) Yabe D. … Honjo T. (Genomics 1998) 2 3 4 23
  2. Molecular cloning of a cDNA encoding human calumenin, expression in Escherichia coli and analysis of its Ca2+-binding activity. (PMID: 9675259) Vorum H. … Honore B. (Biochim. Biophys. Acta 1998) 3 4 23
  3. Genetic determinants of warfarin dosing in the Han-Chinese population. (PMID: 19958090) Lee M.T. … Chen Y.T. (Pharmacogenomics 2009) 3 23 49
  4. Genetic determinants of acenocoumarol and phenprocoumon maintenance dose requirements. (PMID: 20020283) Cadamuro J. … Oberkofler H. (Eur. J. Clin. Pharmacol. 2010) 3 23 49
  5. Human calumenin localizes to the secretory pathway and is secreted to the medium. (PMID: 10222138) Vorum H. … Honore B. (Exp. Cell Res. 1999) 3 4 23

Products for CALU Gene

Sources for CALU Gene

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