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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CALU Gene

protein-coding   GIFtS: 57
GCID: GC07P128381

calumenin

 Explore 14 diseases affiliated with
CALU via our new
 Human Malady Compendium 
Biological research products
for CALU
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Calumenin1
IEF SSP 93022 3
Crocalbin-Like Protein2
Multiple EF-Hand Protein2
Crocalbin3

External Ids:    HGNC: 14581   Entrez Gene: 8132   Ensembl: ENSG000001285957   OMIM: 6034205   UniProtKB: O438523   

Export aliases for CALU gene to outside databases

Previous GC identifers: GC07P126856 GC07P127919 GC07P127933 GC07P127973 GC07P128166 GC07P128380 GC07P122740


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CALU:
The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in
such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC)
that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants
encoding different isoforms have been identified. (provided by RefSeq, Oct 2008)

UniProtKB/Swiss-Prot: CALU_HUMAN, O43852
Function: Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems
to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity)

Gene Wiki entry for CALU


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CALU gene promoter:
         AhR   HTF   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   C/EBPalpha   Evi-1   Arnt   PPAR-alpha   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): CALU promoter sequence
   Search SABiosciences Chromatin IP Primers for CALU

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CALU


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32.1   Ensembl cytogenetic band:  7q32.1   HGNC cytogenetic band: 7q32

CALU Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALU gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P128381:  view genomic region     (about GC identifiers)

Start:
128,379,346 bp from pter      End:
128,411,861 bp from pter
Size:
32,516 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 127,762,331-127,794,515     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CALU_HUMAN, O43852 (See protein sequence)
Recommended Name: Calumenin precursor  
Size: 315 amino acids; 37107 Da
Subunit: Interacts with GGCX (By similarity)
Subcellular location: Endoplasmic reticulum lumen. Secreted. Melanosome. Sarcoplasmic reticulum lumen (By similarity).
Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
Secondary accessions: B3KPG9 D6QS48 D6QS49 D6QS50 D6QS51 D6QS52 D6QS53 D6QS54 D6QS55 D6QS56 D6QS57
D6QS58 D6QS59 F5H1Q9 F5H879 O60456 Q6FHB9 Q96RL3 Q9NR43
Alternative splicing: 15 isoforms:  O43852-1   O43852-2   O43852-3   O43852-4   O43852-5   O43852-6   O43852-7   O43852-8   
O43852-9   O43852-10   O43852-11   O43852-12   O43852-13   O43852-14   O43852-15   

Explore the universe of human proteins at neXtProt for CALU: NX_O43852

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43852

  • CALU Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (6 alternative transcripts): 
    NP_001124146.1  NP_001186600.1  NP_001186601.1  NP_001186602.1  NP_001210.1  NP_001186603.1  

    ENSEMBL proteins: 
     ENSP00000249364   ENSP00000408838   ENSP00000420381   ENSP00000417973   ENSP00000438248  
     ENSP00000439139   ENSP00000442110   ENSP00000438994  
    Reactome Protein details: O43852
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: CALU
    OriGene Protein Over-expression Lysate (see all 2): CALU
    OriGene Custom Protein Services for CALU 
    GenScript Custom Purified and Recombinant Proteins Services for CALU
    Novus Biologicals CALU Proteins
    Novus Biologicals CALU Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CALU
    Uscn Proteins for CALU

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005783endoplasmic reticulum IDA--
    GO:0005794Golgi apparatus TAS9218460
    GO:0033018sarcoplasmic reticulum lumen IEA--
    GO:0042470melanosome IEA--


    CALU for ontologies           About GeneDecksing



    CALU Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CALU 
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    GenScript Custom Superior Antibodies Services for CALU
    Novus Biologicals CALU Antibodies
    Abcam antibodies for CALU 
    Uscn Antibodies for CALU
    Search ThermoFisher Antibodies for CALU

    Assay Products for CALU: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CALU
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CALU


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CALU for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_Ca-bd
     IPR018247 EF_Hand_1_Ca_BS
     IPR027239 Calumenin

    Graphical View of Domain Structure for InterPro Entry O43852

    ProtoNet protein and cluster: O43852

    UniProtKB/Swiss-Prot: CALU_HUMAN, O43852
    Similarity: Belongs to the CREC family
    Similarity: Contains 6 EF-hand domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CALU_HUMAN, O43852
    Function: Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems
    to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity)

         Genatlas biochemistry entry for CALU:
    calumenin CA++ binding proteins in the ER and Golgi apparatus,EF hand subfamily,ubiquitously expressed
    (heart,placenta,skeletal muscle)

    miRNA
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    OriGene 3'-UTR Clone (see all 2): CALU
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALU
    8/123 QIAGEN miScript miRNA Assays for microRNAs that regulate CALU (see all 123):
    hsa-miR-140-5p hsa-miR-193a-3p hsa-miR-3607-3p hsa-miR-1224-3p hsa-miR-15a hsa-miR-199a-3p hsa-miR-200a hsa-miR-605
    SwitchGear 3'UTR luciferase reporter plasmidCALU 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CALU (see all 7)
    OriGene shRNA RFP: CALU
    OriGene siRNA: CALU
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALU

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CALU (see all 5)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 6): CALU (NM_001130674)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALU
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALU 

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    Search LifeMap BioReagents cell lines for CALU

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALU

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IDA10094503
    GO:0005515protein binding IPI18688696


    CALU for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Platelet degranulation
    Platelet degranulation 1.00
    Response to elevated platelet cytosolic Ca2+0.94
    2Platelet activation, signaling and aggregation
    Platelet activation, signaling and aggregation1.00
    Hemostasis0.43
    3Ca, cAMP and Lipid Signaling
    Ca, cAMP and Lipid Signaling1.00
    4Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
    Warfarin Pathway, Pharmacodynamics0.67

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CALU
        Ca, cAMP and Lipid Signaling

    4        Reactome Pathways for CALU
        Hemostasis
    Platelet degranulation
    Platelet activation, signaling and aggregation
    Response to elevated platelet cytosolic Ca2+

    1 PharmGKB Pathway for CALU
        Warfarin Pathway, Pharmacodynamics


    CALU for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CALU

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/17 Interacting proteins for CALU (O438523 ENSP000002493644) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP1LC3AQ9H4923, ENSP000003639704I2D: score=2 STRING: ENSP00000363970
    AURKAO149653, ENSP000002169114I2D: score=1 STRING: ENSP00000216911
    CFTRP135693, ENSP000000030844I2D: score=1 STRING: ENSP00000003084
    APCSP027433, ENSP000002550404I2D: score=2 STRING: ENSP00000255040
    APPP050673I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002576platelet degranulation TAS--
    GO:0007596blood coagulation TAS--
    GO:0008150biological_process ND--
    GO:0030168platelet activation TAS--


    CALU for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CALU for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CALU

    1 HMDB Compound for CALU    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    2 Novoseek chemical compound relationships for CALU gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    warfarin 65.2 13 16493479 (3), 17049586 (1), 20200517 (1), 19958090 (1)
    calcium 0 2 10094503 (2)

    1 PharmGKB related drug/compound annotation for CALU gene
    Drug/compound PharmGKB Annotation
    warfarinCA  
    About this table

    Search CenterWatch for drugs/clinical trials and news about CALU 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CALU gene (6 alternative transcripts): 
    NM_001130674.2  NM_001199671.1  NM_001199672.1  NM_001199673.1  NM_001219.4  NM_001199674.1  

    Unigene Cluster for CALU:

    Calumenin
    Hs.743262  [show with all ESTs]
    Unigene Representative Sequence: NM_001199672
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000249364 ENST00000449187 ENST00000479257 ENST00000493278 ENST00000542996(uc022ald.1 uc003vns.3 uc022ali.1)
    ENST00000535623(uc003vnr.3 uc003vnq.3 uc022alg.1 uc022alh.1)
    ENST00000535011(uc022ale.1) ENST00000538546(uc022alf.1)

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    OriGene 3'-UTR Clone (see all 2): CALU
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALU
    8/123 QIAGEN miScript miRNA Assays for microRNAs that regulate CALU (see all 123):
    hsa-miR-140-5p hsa-miR-193a-3p hsa-miR-3607-3p hsa-miR-1224-3p hsa-miR-15a hsa-miR-199a-3p hsa-miR-200a hsa-miR-605
    SwitchGear 3'UTR luciferase reporter plasmidCALU 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CALU (see all 7)
    OriGene shRNA RFP: CALU
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALU
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 6): CALU (NM_001130674)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALU
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALU 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALU
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALU

    Additional cDNA sequence: 

    AF013759.1 AF257659.1 AF345637.1 AK027460.1 AK056338.1 AK074862.1 AK075089.1 AK312446.1 
    BC013383.2 BT006826.1 BT020143.1 CR457039.1 CR541835.1 HM002604.1 HM002605.1 HM002606.1 
    HM002607.1 HM002609.1 HM002610.1 HM002611.1 HM002616.1 U67280.1 

    24/49 DOTS entries (see all 49):

    DT.453523  DT.92037066  DT.121047127  DT.121047076  DT.101958611  DT.95170418  DT.121047139  DT.95170435 
    DT.100877836  DT.100877826  DT.91861342  DT.100877835  DT.95170427  DT.121047174  DT.121047131  DT.95202996 
    DT.121047122  DT.100877832  DT.121047145  DT.95072231  DT.121047092  DT.100877830  DT.40126389  DT.422708 

    24/1113 AceView cDNA sequences (see all 1113):

    BE501694 AI669474 BC013383 N83742 AW513921 AI753780 AI753513 BP355706 
    CB109898 BP364028 BP337797 AI829693 CR598627 AI088997 BI492846 N42627 
    AA599874 AI753195 BI869322 AA088584 BP335777 BQ008131 AI753539 BP374366 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for CALU (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
    SP1:                                                  -     -                       -     -                                                                     
    SP2:                          -     -                 -     -                       -     -                                                                     
    SP3:                          -     -                 -     -     -     -     -                                                                                 
    SP4:                          -     -                 -     -                 -     -     -     -                                                               
    SP5:                          -     -     -     -     -     -     -     -     -     -     -                                                                     


    ECgene alternative splicing isoforms for CALU

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CALU expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CACTTGAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CALU Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CALU

    SOURCE GeneReport for Unigene cluster: Hs.743262

    UniProtKB/Swiss-Prot: CALU_HUMAN, O43852
    Tissue specificity: Ubiquitously expressed. Expressed at high levels in heart, placenta and skeletal muscle, at lower
    levels in lung, kidney and pancreas and at very low levels in brain and liver

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALU

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CALU gene from 7/26 species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia CALU6
    --
    88(a)
    1 ↔ 1
    GL343828.1(130342-143921)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.334512 Xenopus laevis transcribed sequence with moderate similarity more 78.25(n)    BU912918.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc637412 similar to calumenin 75.23(n)   394057  BC055227.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta scf1 , 3 DNA supercoiling3
    supercoiling factor1
    55(a)
    (best of 2)3
    56.62(n)1
    50.32(a)1
      61F53
    381451  NM_058044.41  NP_477392.11 
    worm
    (Caenorhabditis elegans)
    Secernentea M03F4.73
    calu-11
    calcium binding protein3
    Protein CALU-11
    50(a)
    (best of 2)3
    53.87(n)1
    51.41(a)1
      X(5005073-5006175)3
    1807691  NM_001029635.41  NP_001024806.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G277906
    AT5G085806
    EF-hand, calcium binding motif-containing protein
    20(a)
    18(a)
    many ↔ many
    many ↔ many
    4(13850046-13851533)
    5(2780512-2783066)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 3)
    EF hand family protein, putative, expressed
    calcium-binding EF hand family protein, putative, ...
    (see all 3)
    19(a)
    16(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    4(34602257-34605106)
    2(6798696-6802474)


    ENSEMBL Gene Tree for CALU (if available)
    TreeFam Gene Tree for CALU (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CALU gene
    RCN32  RCN12  RCN22  SDF42  
    3 SIMAP similar genes for CALU using alignment to 3 protein entries:     CALU_HUMAN (see all proteins):
    RCN1    RCN3    RCN2

    CALU for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/556 NCBI SNPs in CALU are shown (see all 556    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs102432191,2
    C,F,A,H,--128377517(+) GATGGC/TGCACC 6 -- us2k1 tfbs310Minor allele frequency- T:0.09NS EA NA CSA WA 638
    rs604250561,2
    C,F,--128377565(+) GTTTAC/TTTTGG 6 -- us2k12Minor allele frequency- T:0.07WA NA 238
    rs777073351,2
    F,--128377614(+) TTGTTA/GTTTTT 6 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1157107371,2
    --128377625(+) ATTTTT/GTAAGA 6 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1427034401,2
    --128377686(+) GTTCAC/TTGCAG 6 -- us2k10--------
    rs1866832871,2
    --128377698(+) CTCAAC/TCTCCT 6 -- us2k10--------
    rs1914959501,2
    --128377744(+) CCACCA/CCACCC 6 -- us2k10--------
    rs746962891,2
    --128377849(+) ATCCTG/TAAGGA 6 -- us2k10--------
    rs1840140691,2
    --128377996(+) TTCAGG/TTTCCT 6 -- us2k10--------
    rs781571191,2
    C,F,--128378152(+) TTCCTA/GTTACT 6 -- us2k11Minor allele frequency- G:0.04WA 118

    HapMap Linkage Disequilibrium report for CALU (128379346 - 128411861 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CALU
         1 CNV: 4559

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CALU
    DNA2.0 Custom Variant and Variant Library Synthesis for CALU

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CALU for disorders           About GeneDecksing

    OMIM gene information: 603420    OMIM disorders: --

    14 diseases for CALU:    About MalaCards
    warfarin sensitivity    squamous cell carcinoma    inflammatory bowel disease    lung squamous cell carcinoma
    tuberous sclerosis    cystic fibrosis    thrombosis    fibrosis
    hepatocellular carcinoma    colorectal cancer    carcinoma    adenoma
    hypertension    malaria

    2 Novoseek disease relationships for CALU gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thrombosis 14.9 2 18688696 (1), 16691550 (1)
    tumors 0 1 20506421 (1)

    Human Genome Epidemiology (HuGE) Navigator: CALU (20 documents)

    Export disorders for CALU gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CALU gene, integrated from 9 sources (see all 75):
    (articles sorted by number of sources associating them with CALU)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human calumenin gene (CALU): cDNA isolation and chromosomal mapping to 7q32. (PubMed id 9598325)1, 2, 3, 9 Yabe D.... Honjo T. (1998)
    2. Human calumenin localizes to the secretory pathway and is secreted to the medium. (PubMed id 10222138)1, 2, 9 Vorum H.... Honore B. (1999)
    3. Molecular cloning of a cDNA encoding human calumenin, expression in Escherichia coli and analysis of its Ca2+-binding activity. (PubMed id 9675259)1, 2, 9 Vorum H.... Honore B. (1998)
    4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    5. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. (PubMed id 12643545)1, 2 Basrur V.... Appella E. (2003)
    9. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    10. Calumenin but not reticulocalbin forms a Ca(2+)-dependent complex with thrombospondin-1. A potential role in haemostasis and thrombosis. (PubMed id 18688696)1, 9 Hansen G.A....Honore B. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 813 HGNC: 1458 AceView: CALU Ensembl:ENSG00000128595 euGenes: HUgn813
    ECgene: CALU H-InvDB: CALU

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CALU Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CALU gene:
    Search GeneIP for patents involving CALU

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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