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CALU Gene

protein-coding   GIFtS: 59
GCID: GC07P128497

Calumenin

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
calumenin1 2
IEF SSP 93022 3
Crocalbin-Like Protein2
Multiple EF-Hand Protein2
Crocalbin3

External Ids:    HGNC: 14581   Entrez Gene: 8132   Ensembl: ENSG000001285957   OMIM: 6034205   UniProtKB: O438523   

Export aliases for CALU gene to outside databases

Previous GC identifers: GC07P126856 GC07P127919 GC07P127933 GC07P127973 GC07P128166 GC07P128380 GC07P122740 GC07P128381 GC07P128438


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CALU Gene:
The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is
involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple
EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene.
Alternatively spliced transcript variants encoding different isoforms have been identified. (provided by RefSeq,
Oct 2008)

GeneCards Summary for CALU Gene:
CALU (calumenin) is a protein-coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is RCN3.

UniProtKB/Swiss-Prot: CALU_HUMAN, O43852
Function: Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues.
Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity)

Gene Wiki entry for CALU Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CALU gene promoter:
         AhR   HTF   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   C/EBPalpha   Evi-1   Arnt   PPAR-alpha   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): CALU promoter sequence
   Search Chromatin IP Primers for CALU

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CALU


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32.1   Ensembl cytogenetic band:  7q32.1   HGNC cytogenetic band: 7q32

CALU Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALU gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P128497:  view genomic region     (about GC identifiers)

Start:
128,379,346 bp from pter      End:
128,413,477 bp from pter
Size:
34,132 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 127,762,331-127,796,461     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CALU_HUMAN, O43852 (See protein sequence)
Recommended Name: Calumenin precursor  
Size: 315 amino acids; 37107 Da
Subunit: Interacts with GGCX (By similarity)
Secondary accessions: B3KPG9 D6QS48 D6QS49 D6QS50 D6QS51 D6QS52 D6QS53 D6QS54 D6QS55 D6QS56
D6QS57 D6QS58 D6QS59 F5H1Q9 F5H879 O60456 Q6FHB9 Q96RL3 Q9NR43
Alternative splicing: 15 isoforms:  O43852-1   O43852-2   O43852-3   O43852-4   O43852-5   O43852-6   O43852-7   O43852-8   
O43852-9   O43852-10   O43852-11   O43852-12   O43852-13   O43852-14   O43852-15   

Explore the universe of human proteins at neXtProt for CALU: NX_O43852

Explore proteomics data for CALU at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys84, Lys94, Lys98, Lys114, Lys255
  • Glycosylation2 at Thr60, Asn131, Ser261
  • Modification sites at PhosphoSitePlus

  • See CALU Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001124146.1  NP_001186600.1  NP_001186601.1  NP_001186602.1  NP_001210.1  

    ENSEMBL proteins: 
     ENSP00000442110   ENSP00000438248   ENSP00000249364   ENSP00000408838   ENSP00000420381  
     ENSP00000417973   ENSP00000439139   ENSP00000438994  
    Reactome Protein details: O43852

    CALU Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CALU
    OriGene Protein Over-expression Lysate for CALU
    OriGene MassSpec for CALU
    OriGene Custom Protein Services for CALU
    GenScript Custom Purified and Recombinant Proteins Services for CALU
    Novus Biologicals CALU Proteins
    Novus Biologicals CALU Lysates
    Sino Biological Recombinant Protein for CALU
    Sino Biological Cell Lysate for CALU
    ProSpec Recombinant Protein for CALU
    Cloud-Clone Corp. Proteins for CALU

     
    Search eBioscience for Proteins for CALU 

     
    antibodies-online proteins for CALU (23 products) 

     
    antibodies-online peptides for CALU

    CALU Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CALU 
    OriGene Antibodies for CALU
    OriGene Custom Antibody Services for CALU
    Novus Biologicals CALU Antibodies
    Abcam antibodies for CALU
    Cloud-Clone Corp. Antibodies for CALU
    Search ThermoFisher Antibodies for CALU
    antibodies-online antibodies for CALU (33 products) 

    CALU Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CALU
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CALU
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CALU
    Cloud-Clone Corp. CLIAs for CALU
    Search eBioscience for ELISAs for CALU 
    antibodies-online kits for CALU (32 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    4 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR018247 EF_Hand_1_Ca_BS
     IPR027239 Calumenin

    Graphical View of Domain Structure for InterPro Entry O43852

    ProtoNet protein and cluster: O43852

    UniProtKB/Swiss-Prot: CALU_HUMAN, O43852
    Similarity: Belongs to the CREC family
    Similarity: Contains 6 EF-hand domains


    Find genes that share domains with CALU           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CALU_HUMAN, O43852
    Function: Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues.
    Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity)

         Genatlas biochemistry entry for CALU:
    calumenin CA++ binding proteins in the ER and Golgi apparatus,EF hand subfamily,ubiquitously expressed
    (heart,placenta,skeletal muscle)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IDA10094503
    GO:0005515protein binding IPI18688696
         
    Find genes that share ontologies with CALU           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CALU

    miRNA
    Products:
        
    miRTarBase miRNAs that target CALU:
    hsa-mir-365a-3p (MIRT044024), hsa-mir-375 (MIRT019978), hsa-mir-7-5p (MIRT025946), hsa-mir-124-3p (MIRT023190), hsa-mir-132-3p (MIRT021863), hsa-mir-122-5p (MIRT023336), hsa-mir-103a-3p (MIRT027157), hsa-mir-155-5p (MIRT021030), hsa-mir-16-5p (MIRT032058), hsa-mir-29b-3p (MIRT048381), hsa-mir-320a (MIRT044559)

    Block miRNA regulation of human, mouse, rat CALU using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CALU (see all 123):
    hsa-miR-140-5p hsa-miR-193a-3p hsa-miR-3607-3p hsa-miR-1224-3p hsa-miR-15a hsa-miR-199a-3p hsa-miR-200a hsa-miR-605
    SwitchGear 3'UTR luciferase reporter plasmidCALU 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CALU
    Predesigned siRNA for gene silencing in human, mouse, rat CALU

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CALU

    Clone
    Products:
         
    OriGene clones in human, mouse for CALU (see all 13)
    OriGene ORF clones in mouse, rat for CALU
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): CALU (NM_001130674)
    Sino Biological Human cDNA Clone for CALU
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALU
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALU

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CALU
    Browse ESI BIO Cell Lines and PureStem Progenitors for CALU 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALU


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CALU_HUMAN, O43852: Endoplasmic reticulum lumen. Secreted. Melanosome. Sarcoplasmic reticulum lumen (By
    similarity). Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular5
    golgi apparatus4
    cytoskeleton1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005783endoplasmic reticulum IDA--
    GO:0005794Golgi apparatus TAS9218460
    GO:0033018sarcoplasmic reticulum lumen IEA--
    GO:0042470melanosome IEA--

    Find genes that share ontologies with CALU           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CALU About    
    See pathways by source

    SuperPathContained pathways About
    1Response to elevated platelet cytosolic Ca2+
    Response to elevated platelet cytosolic Ca2+0.94
    Platelet degranulation0.94
    2Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43
    3PTM- gamma carboxylation, hypusine formation and arylsulfatase activation
    Warfarin Pathway, Pharmacodynamics0.31
    4Ca, cAMP and Lipid Signaling
    Ca, cAMP and Lipid Signaling


    Find genes that share SuperPaths with CALU           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CALU
        Ca, cAMP and Lipid Signaling


    1 Reactome Pathway for CALU
        Platelet degranulation

    1 PharmGKB Pathway for CALU
        Warfarin Pathway, Pharmacodynamics

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CALU
    Interactions:

        GeneGlobe Interaction Network for CALU

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for CALU (O438523 ENSP000002493644) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP1LC3AQ9H4923, ENSP000003639704I2D: score=2 STRING: ENSP00000363970
    AURKAO149653, ENSP000002169114I2D: score=1 STRING: ENSP00000216911
    CFTRP135693, ENSP000000030844I2D: score=1 STRING: ENSP00000003084
    APCSP027433, ENSP000002550404I2D: score=2 STRING: ENSP00000255040
    APPP050673I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002576platelet degranulation TAS--
    GO:0007596blood coagulation TAS--
    GO:0008150biological_process ND--
    GO:0030168platelet activation TAS--

    Find genes that share ontologies with CALU           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CALU

    1 HMDB Compound for CALU    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    2 Novoseek inferred chemical compound relationships for CALU gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    warfarin 65.2 13 16493479 (3), 17049586 (1), 20200517 (1), 19958090 (1)
    calcium 0 2 10094503 (2)

    1 PharmGKB related drug/compound annotation for CALU gene    About this table
    Drug/compound PharmGKB Annotation
    warfarinCA  



    Find genes that share compounds with CALU           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CALU gene (6 alternative transcripts): 
    NM_001130674.2  NM_001199671.1  NM_001199672.1  NM_001199673.1  NM_001219.4  NM_001199674.1  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000535011(uc022ale.1) ENST00000542996(uc022ald.1 uc003vns.3 uc022ali.1)
    ENST00000249364 ENST00000449187 ENST00000479257 ENST00000493278 ENST00000535623(uc003vnr.3 uc003vnq.3 uc022alg.1 uc022alh.1)
    ENST00000538546(uc022alf.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CALU using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CALU (see all 123):
    hsa-miR-140-5p hsa-miR-193a-3p hsa-miR-3607-3p hsa-miR-1224-3p hsa-miR-15a hsa-miR-199a-3p hsa-miR-200a hsa-miR-605
    SwitchGear 3'UTR luciferase reporter plasmidCALU 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CALU
    Predesigned siRNA for gene silencing in human, mouse, rat CALU
    Clone
    Products:
         
    OriGene clones in human, mouse for CALU (see all 13)
    OriGene ORF clones in mouse, rat for CALU
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): CALU (NM_001130674)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALU
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALU
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CALU
    OriGene qSTAR qPCR primer pairs in human, mouse for CALU
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CALU
      QuantiTect SYBR Green Assays in human, mouse, rat CALU
      QuantiFast Probe-based Assays in human, mouse, rat CALU

    Selected AceView cDNA sequences (see all 1113):

    N27556 BM464082 AI090690 BQ416741 CD367093 AA353771 AW631012 AI190285 
    BM835016 AI240632 AA113080 CB240831 BP365995 BQ008210 CA420572 N42627 
    BQ021017 BM834064 AA580800 AA301579 AA253259 CR598627 AI084678 AI349334 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CALU (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
    SP1:                                                  -     -                       -     -                                                                     
    SP2:                          -     -                 -     -                       -     -                                                                     
    SP3:                          -     -                 -     -     -     -     -                                                                                 
    SP4:                          -     -                 -     -                 -     -     -     -                                                               
    SP5:                          -     -     -     -     -     -     -     -     -     -     -                                                                     


    ECgene alternative splicing isoforms for CALU

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CALU expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACTTGAAAA
    CALU Expression
    About this image


    CALU expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    CALU Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CALU Protein Expression

    UniProtKB/Swiss-Prot: CALU_HUMAN, O43852
    Tissue specificity: Ubiquitously expressed. Expressed at high levels in heart, placenta and skeletal muscle, at
    lower levels in lung, kidney and pancreas and at very low levels in brain and liver

        Custom PCR Arrays for CALU
    Primer
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    OriGene qPCR primer pairs and template standards for CALU
    OriGene qSTAR qPCR primer pairs in human, mouse for CALU
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CALU
    QuantiTect SYBR Green Assays in human, mouse, rat CALU
    QuantiFast Probe-based Assays in human, mouse, rat CALU
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALU

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CALU gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Calu1 , 5 calumenin1, 5 87.94(n)1
    91.75(a)1
      6 (12.36 cM)5
    123211  NM_184053.31  NP_908942.11 
     293480695 
    lizard
    (Anolis carolinensis)
    Reptilia CALU6
    calumenin
    77(a)
    1 ↔ 1
    GL343828.1(128883-152327)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.334512 Xenopus laevis transcribed sequence with moderate similarity more 78.25(n)    BU912918.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc637412 similar to calumenin 75.23(n)   394057  BC055227.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta scf1 , 3 DNA supercoiling3
    supercoiling factor1
    55(a)
    (best of 2)3
    57.1(n)1
    51.94(a)1
      61F53
    381451  NM_058044.51  NP_477392.11 
    worm
    (Caenorhabditis elegans)
    Secernentea M03F4.73
    calu-11
    calcium binding protein3
    calu-11
    50(a)
    (best of 2)3
    54(n)1
    51.33(a)1
      X(5005073-5006175)3
    1807691  NM_001029635.51  NP_001024806.11 


    ENSEMBL Gene Tree for CALU (if available)
    TreeFam Gene Tree for CALU (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CALU gene
    RCN32  RCN12  SDF42  RCN22  
    3 SIMAP similar genes for CALU using alignment to 3 protein entries:     CALU_HUMAN (see all proteins):
    RCN1    RCN3    RCN2

    Find genes that share paralogs with CALU           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CALU (see all 724)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs360353641,2
    C--127768480(+) CAACA-/TTTTTTT 6 -- int10--------
    rs2008760341,2
    C--127768480(+) CAACA-/TTTTTTT 6 -- int10--------
    rs1469311891,2
    C--127770173(+) CTGTT-/TTTA  
            
    TTTGT
    6 -- int10--------
    rs581732301,2
    C--127770176(+) TTTTT-/ATTT  
            
    GTTTT
    6 -- int10--------
    rs779992061,2
    C,F--127774594(-) TGGAAG/ACAAGG 6 -- int12Minor allele frequency- A:0.50NA 4
    rs767332371,2
    C,F--127774635(+) TGGCAC/TATGCC 6 -- int13Minor allele frequency- T:0.50NA 8
    rs768614241,2
    C--127774648(+) TAGTCT/CCAGCT 6 -- int11Minor allele frequency- C:0.00NA 2
    rs781014651,2
    C--127774661(+) TAAGGA/CGGCTG 6 -- int10--------
    rs106384441,2
    C--127780396(+) TTTGA-/GTGT  
            
    gtgtg
    6 -- int10--------
    rs353961061,2
    C--127780397(+) TTGAG-/GT    
       
    /GTGT
    TGTGT
    6 -- int10--------

    HapMap Linkage Disequilibrium report for CALU (128379346 - 128413477 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CALU:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2735137CNV Deletion23290073
    esv2670312CNV Deletion23128226
    nsv831125CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CALU
    DNA2.0 Custom Variant and Variant Library Synthesis for CALU

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603420    OMIM disorders: --


    Find genes that share disorders with CALU           About GenesLikeMe

    2 Novoseek inferred disease relationships for CALU gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thrombosis 14.9 2 18688696 (1), 16691550 (1)
    tumors 0 1 20506421 (1)

    Genetic Association Database (GAD): CALU
    Human Genome Epidemiology (HuGE) Navigator: CALU (20 documents)

    Export disorders for CALU gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CALU gene, integrated from 10 sources (see all 91):
    (articles sorted by number of sources associating them with CALU)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human calumenin gene (CALU): cDNA isolation and chromosomal mapping to 7q32. (PubMed id 9598325)1, 2, 3, 9 Yabe D.... Honjo T. (Genomics 1998)
    2. Human calumenin localizes to the secretory pathway and is secreted to the medium. (PubMed id 10222138)1, 2, 9 Vorum H.... Honore B. (Exp. Cell Res. 1999)
    3. Molecular cloning of a cDNA encoding human calumenin, expression in Escherichia coli and analysis of its Ca2+-binding activity. (PubMed id 9675259)1, 2, 9 Vorum H.... Honore B. (Biochim. Biophys. Acta 1998)
    4. Genetic determinants of acenocoumarol and phenprocoumon maintenance dose requirements. (PubMed id 20020283)1, 4, 9 Cadamuro J....Oberkofler H. (Eur. J. Clin. Pharmacol. 2010)
    5. Polymorphisms in vitamin K-dependent gamma-carboxylation-related genes influence interindividual variability in plasma protein C and protein S activities in the general population. (PubMed id 17189218)1, 4, 9 Kimura R....Miyata T. (Int. J. Hematol. 2006)
    6. Genotypes of vitamin K epoxide reductase, gamma-glutamyl carboxylase, and cytochrome P450 2C9 as determinants of daily warfarin dose in Japanese patients. (PubMed id 17049586)1, 4, 9 Kimura R....Miyata T. (Thromb. Res. 2007)
    7. Genetic determinants of warfarin dosing in the Han-Chinese population. (PubMed id 19958090)1, 4, 9 Lee M.T....Chen Y.T. (Pharmacogenomics 2009)
    8. Association of warfarin dose with genes involved in its action and metabolism. (PubMed id 17048007)1, 4, 9 Wadelius M....Deloukas P. (Hum. Genet. 2007)
    9. The genetic interaction between VKORC1 c1173t and calumenin a29809g modulates the anticoagulant response of acenocoumarol. (PubMed id 17596133)1, 4, 9 GonzA!lez-Conejero R....Vicente V. (J. Thromb. Haemost. 2007)
    10. Genetic factors (VKORC1, CYP2C9, EPHX1, and CYP4F2) are predictor variables for warfarin response in very elderly, frail inpatients. (PubMed id 19794411)1, 4 Pautas E....Siguret V. (Clin. Pharmacol. Ther. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 813 HGNC: 1458 AceView: CALU Ensembl:ENSG00000128595 euGenes: HUgn813
    ECgene: CALU H-InvDB: CALU

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CALU Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CALU gene:
    Search GeneIP for patents involving CALU

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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