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CALR3 Gene

protein-coding   GIFtS: 50
GCID: GC19M016589

Calreticulin 3

  See CALR3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calreticulin 31 2     CT932
CRT22 3 5     calreticulin-22
calsperin1 2     calreticulin-32
Cancer/Testis Antigen 931 2     Calreticulin-23
CMH192 5     Calsperin3

External Ids:    HGNC: 204071   Entrez Gene: 1259722   Ensembl: ENSG000002690587   OMIM: 6114145   UniProtKB: Q96L123   

Export aliases for CALR3 gene to outside databases

Previous GC identifers: GC19M016982 GC19M016435 GC19M016450 GC19M016158


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CALR3 Gene:
The protein encoded by this gene belongs to the calreticulin family, members of which are calcium-binding
chaperones localized mainly in the endoplasmic reticulum. This protein is also localized to the endoplasmic
reticulum lumen, however, its capacity for calcium-binding may be absent or much lower than other family members.
This gene is specifically expressed in the testis, and may be required for sperm fertility. Mutation in this gene
has been associated with familial hypertrophic cardiomyopathy. (provided by RefSeq, Dec 2011)

GeneCards Summary for CALR3 Gene:
CALR3 (calreticulin 3) is a protein-coding gene. Diseases associated with CALR3 include cardiomyopathy, familial hypertrophic, 19, and familial hypertrophic cardiomyopathy. GO annotations related to this gene include unfolded protein binding and calcium ion binding. An important paralog of this gene is CLGN.

UniProtKB/Swiss-Prot: CALR3_HUMAN, Q96L12
Function: During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as
ADAM3. Required for sperm fertility (By similarity). CALR3 capacity for calcium-binding may be absent or much
lower than that of CALR




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the CALR3 gene promoter:
         AP-1   MEF-2   Meis-1b   MEF-2A   POU2F1   POU2F1a   aMEF-2   Meis-1a   Pax-4a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCALR3 promoter sequence
   Search Chromatin IP Primers for CALR3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CALR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.11

CALR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALR3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M016589:  view genomic region     (about GC identifiers)

Start:
16,589,868 bp from pter      End:
16,607,003 bp from pter
Size:
17,136 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CALR3_HUMAN, Q96L12 (See protein sequence)
Recommended Name: Calreticulin-3 precursor  
Size: 384 amino acids; 44996 Da
Subunit: Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and
HSPA5 (By similarity)
Secondary accessions: D9N574 Q96LN3

Explore the universe of human proteins at neXtProt for CALR3: NX_Q96L12

Explore proteomics data for CALR3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn42, Asn201
  • Modification sites at PhosphoSitePlus

  • See CALR3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_659483.2  
    ENSEMBL proteins: 
     ENSP00000269881   ENSP00000471533  

    CALR3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CALR3

     
    Search eBioscience for Proteins for CALR3 

     
    antibodies-online proteins for CALR3 (9 products) 

     
    antibodies-online peptides for CALR3

    CALR3 Antibody Products:

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    antibodies-online antibodies for CALR3 (27 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR018124 Calret/calnex_CS
     IPR013320 ConA-like_subgrp
     IPR009033 Calreticulin/calnexin_P_dom
     IPR009169 Calreticulin
     IPR001580 Calret/calnex

    Graphical View of Domain Structure for InterPro Entry Q96L12

    ProtoNet protein and cluster: Q96L12

    1 Blocks protein domain: IPB001580 Calreticulin

    UniProtKB/Swiss-Prot: CALR3_HUMAN, Q96L12
    Domain: Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like
    structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas
    the acidic C-domain binds multiple calcium ions with low affinity (By similarity)
    Domain: The interaction with glycans occurs through a binding site in the globular lectin domain (By similarity)
    Domain: The zinc binding sites are localized to the N-domain (By similarity)
    Similarity: Belongs to the calreticulin family


    Find genes that share domains with CALR3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CALR3_HUMAN, Q96L12
    Function: During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as
    ADAM3. Required for sperm fertility (By similarity). CALR3 capacity for calcium-binding may be absent or much
    lower than that of CALR

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
    GO:0051082unfolded protein binding IEA--
         
    Find genes that share ontologies with CALR3           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Calr3):
     reproductive system 

    Find genes that share phenotypes with CALR3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Calr3tm1Osb for CALR3

       genOway: Develop your customized and physiologically relevant rodent model for CALR3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CALR3_HUMAN, Q96L12: Endoplasmic reticulum lumen
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum ----
    GO:0005788endoplasmic reticulum lumen IEA--

    Find genes that share ontologies with CALR3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CALR3
    Interactions:

        Search GeneGlobe Interaction Network for CALR3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for CALR3 (Q96L123 ENSP000002698814) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRRM2Q9UQ353, ENSP000003017404I2D: score=1 STRING: ENSP00000301740
    RAD1ENSP000003408794STRING: ENSP00000340879
    UBE2KENSP000002614274STRING: ENSP00000261427
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--
    GO:0007283spermatogenesis IEA--
    GO:0030154cell differentiation IEA--

    Find genes that share ontologies with CALR3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CALR3

    1 HMDB Compound for CALR3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CALR3 gene: 
    NM_145046.4  

    Unigene Cluster for CALR3:

    Calreticulin 3
    Hs.304020  [show with all ESTs]
    Unigene Representative Sequence: NM_145046
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000269881(uc002ned.2) ENST00000602234 ENST00000600762
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat CALR3

    Additional mRNA sequence: 

    AB576176.1 AK058084.1 BC014595.2 

    3 DOTS entries:

    DT.121500718  DT.92414891  DT.432205 

    17 AceView cDNA sequences:

    AI222024 AK058084 BP369290 BC014595 BI462994 BI827528 BI827976 NM_145046 
    BF979888 BG716900 AA724300 BF979336 BI562181 AA724299 BP370084 BI831833 
    AA910019 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CALR3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATTTTACA
    CALR3 Expression
    About this image

    CALR3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CALR3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.304020

    UniProtKB/Swiss-Prot: CALR3_HUMAN, Q96L12
    Tissue specificity: Testis specific

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CALR3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Calr31 , 5 calreticulin 31, 5 81.71(n)1
    83.91(a)1
      8 (35.08 cM)5
    733161  NM_028500.31  NP_082776.21 
     724241765 
    chicken
    (Gallus gallus)
    Aves CALR36
    calreticulin 3
    49(a)
    1 ↔ 1
    28(4100227-4103457)
    lizard
    (Anolis carolinensis)
    Reptilia CALR36
    calreticulin 3
    61(a)
    1 ↔ 1
    AAWZ02040966(725-2425)
    zebrafish
    (Danio rerio)
    Actinopterygii calrl6
    calr6
    calreticulin
    45(a)
    45(a)
    1 ↔ many
    1 ↔ many
    2(55840231-55854933) ENSDARG00000020103
    22(4339290-4410265) ENSDARG00000043276
    fruit fly
    (Drosophila melanogaster)
    Insecta Crc6
    Calreticulin
    38(a)
    1 → many
    3R(5454660-5456607)
    worm
    (Caenorhabditis elegans)
    Secernentea crt-16
    Protein CRT-1 (crt-1) mRNA, complete cds
    42(a)
    1 → many
    V(6098993-6100553) WBGene00000802
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CNE16
    Calnexin; integral membrane ER chaperone involved ...
    17(a)
    1 → many
    I(37464-38972) YAL058W
    rice
    (Oryza sativa)
    Liliopsida Os.92132 Oryza sativa (japonica cultivar-group) cDNA cloneJ013055B02, full insert sequence less 70.25(n)    NM_190260.1 


    ENSEMBL Gene Tree for CALR3 (if available)
    TreeFam Gene Tree for CALR3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CALR3 gene
    CLGN2  CANX2  CALR2  
    1 SIMAP similar gene for CALR3 using alignment to 2 protein entries:     CALR3_HUMAN (see all proteins):
    CALR

    Find genes that share paralogs with CALR3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CALR3 (see all 472)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0654764
    Cardiomyopathy, familial hypertrophic 19 (CMH19)4--see VAR_0654762 K R mis40--------
    rs1509776071,2
    C--16165571(+) AGACA-/GGGTTT 1 -- int10--------
    rs2002422611,2
    C--16166344(+) ATCTC-/A/AA  
            
    AAAAA
    1 -- int10--------
    rs81137931,2
    C,A--16521867(+) ctactG/Caggag 1 -- ds50015Minor allele frequency- C:0.10NA 10
    rs80998871,2
    C,A--16521940(+) cagctA/Cctttt 1 -- ds50015Minor allele frequency- C:0.10NA 10
    rs1394779971,2
    C--16522011(+) TCAAGG/TGATCC 1 -- ds50010--------
    rs1496922321,2
    C--16522016(+) TGATCA/CGCCCA 1 -- ds50010--------
    rs1117287891,2
    F--16522132(+) TTGGCC/G/TAGACC 1 -- ds50012CSA WA 119
    rs81035211,2
    C,F,A,H--16522160(+) TCCAGC/TGTGTA 1 -- ds500121Minor allele frequency- T:0.36NS EA NA CSA WA 2348
    rs596495531,2
    F--16522176(+) GTCAAG/CAGGGA 1 -- ds50011Minor allele frequency- C:0.04WA 118

    HapMap Linkage Disequilibrium report for CALR3 (16589868 - 16607003 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CALR3: --
    Human Gene Mutation Database (HGMD): CALR3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CALR3
    DNA2.0 Custom Variant and Variant Library Synthesis for CALR3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611414   
    OMIM disorders: 613875  
    UniProtKB/Swiss-Prot: CALR3_HUMAN, Q96L12
  • Cardiomyopathy, familial hypertrophic 19 (CMH19) [MIM:613875]: A hereditary heart disorder characterized
    by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The
    symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by
    exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high
    risk of cardiac failure and sudden cardiac death. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 3 diseases for CALR3:    
    About MalaCards
    cardiomyopathy, familial hypertrophic, 19    familial hypertrophic cardiomyopathy    hypertrophic cardiomyopathy

    1 disease from the University of Copenhagen DISEASES database for CALR3:
    Familial hypertrophic cardiomyopathy

    Find genes that share disorders with CALR3           About GenesLikeMe


    Export disorders for CALR3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CALR3 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with CALR3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel calreticulin isoform (Crt2) in human and mouse. (PubMed id 12384296)1, 2, 3, 9 Persson S.... Sommarin M. (Gene 2002)
    2. Calreticulin-2 is localized in the lumen of the endoplasmic reticulum but is not a Ca2+ -binding protein. (PubMed id 21590275)1, 2 Nomura R.... Senda T. (Histochem. Cell Biol. 2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Genetic screening of calcium regulation genes in familial hypertrophic cardiomyopathy. (PubMed id 17655857)2, 9 Chiu C....Semsarian C. (J. Mol. Cell. Cardiol. 2007)
    6. Multiple loci are associated with white blood cell phenotypes. (PubMed id 21738480)1 Nalls M.A....Ganesh S.K. (PLoS Genet. 2011)
    7. Identification of a novel cancer-testis antigen CRT2 frequently expressed in various cancers using representational differential analysis. (PubMed id 17975137)1 Hayashi E....Kawakami Y. (Clin. Cancer Res. 2007)
    8. Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin. (PubMed id 16159877)1 McCracken S....Blencowe B.J. (J. Biol. Chem. 2005)
    9. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    10. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 125972 HGNC: 20407 AceView: CALR3 Ensembl:ENSG00000269058 euGenes: HUgn125972
    ECgene: CALR3 H-InvDB: CALR3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CALR3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CALR3 gene:
    Search GeneIP for patents involving CALR3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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