V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

CALR Gene

protein-coding GIFtS: 68

GC19P012910

calreticulin
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CRP55 ^³
CRT ^¹, ²
CRTC ^³
Calregulin ^³
ERp60 ^³
FLJ26680 ^¹, ²
HACBP ^³
RO ^¹, ²
SSA ^¹, ², ⁵
cC1qR ^¹, ²
calreticulin ^²
grp60 ^³

Descriptions
Sicca syndrome antigen A (autoantigen Ro; calreticulin) ^²
autoantigen Ro ^²

External Ids
HGNC: 1455¹
Entrez Gene: 811²
UniProtKB: P27797³
Ensembl: ENSG00000179218⁷

Search outside databases for aliases for CALR gene

Previous GC identifers: GC19P013180 GC19P013272 GC19P012894

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CALR:

Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in

the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may

have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR,

which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily

of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and

Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and

it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino

terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and

prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin

can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit

androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as

retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important

modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus

erythematosus is associated with increased autoantibody titers against calreticulin but

calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A

antigen but this was later disproven. Increased autoantibody titer against human calreticulin is

found in infants with complete congenital heart block of both the IgG and IgM classes. [provided

by RefSeq]

UniProtKB/Swiss-Prot: CALR_HUMAN, P27797

Function: Molecular calcium binding chaperone promoting folding, oligomeric assembly and quality

control in the ER via the calreticulin/calnexin cycle. This lectin interacts transiently with

almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with

the DNA-binding domain of NR3C1 and mediates its nuclear export

Gene Wiki entry for CALR (Calreticulin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CALR gene

Entrez Gene cytogenetic band: 19p13.3-p13.2 Ensembl cytogenetic band: 19p13.13 HGNC cytogenetic band: 19p13.3-p13.2

CALR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P012910: (about GC identifiers)

Start:	12,910,423 bp from pter
End:	12,916,303 bp from pter
Size:	5,881 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000019.8 NT_011295.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CALR_HUMAN, P27797 (See protein sequence)

Recommended Name: Calreticulin precursor

Size: 417 amino acids; 48142 Da

Subunit: Monomer. Component of an EIF2 complex at least composed of CUGBP1, CALR, CALR3, EIF2S1,

EIF2S2, HSP90B1 and HSPA5. Interacts with PDIA3/ERp57 and with NR3C1 (By similarity)

Subcellular location: Endoplasmic reticulum lumen. Cytoplasm, cytosol. Secreted, extracellular

space, extracellular matrix. Cell surface. Note=Also found in cell surface (T cells), cytosol and

extracellular matrix. Associated with the lytic granules in the cytolytic T-lymphocytes

Mass spectrometry: Mass=46879; Method=MALDI; Range=18-417; Source=PubMed:11149926;

Caution: Was originally (PubMed:2332496) thought to be the 52 kDa Ro autoantigen

PDB structure from and Proteopedia :

2CLR (3D)

3DOW (3D)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004334.1

ENSEMBL proteins:

ENSP00000320866

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Calreticulin)
	Human Recombinant Proteins from Abnova (CALR)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/13 Gene Ontology (GO) cellular component terms (links to tree view) (see all 13 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005615	extracellular space	IEA	--
GO:0005634	nucleus	IDA	8107809
GO:0005737	cytoplasm	IEA	--

About this table

Antibodies for CALR:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of CALR
	Sigma-Aldrich Antibody Arrays and Antibodies for CALR
	R&D Systems Antibodies for CALR (Vasostatin)
	Cell Signaling Technology (CST) Antibodies for CALR (calreticulin)
	Antibodies from Abcam (Calreticulin), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CALR)
	Novus Biologicals Antibodies for CALR

Assays for CALR:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P27797

ProtoNet protein and cluster: P27797

1 Blocks protein family: IPB001580 Calreticulin

UniProtKB/Swiss-Prot: CALR_HUMAN, P27797

Domain: Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an

elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of

calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low

affinity

Domain: The interaction with glycans occurs through a binding site in the globular lectin domain

Domain: The zinc binding sites are localized to the N-domain

Domain: Associates with PDIA3 through the tip of the extended arm formed by the P-domain

Similarity: Belongs to the calreticulin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CALR)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CALR)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004343

Applied Biosystems Silencer® siRNAs for CALR

Sigma-Aldrich siRNA for CALR

Sigma-Aldrich shRNA Panels and shRNA for CALR

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CALR
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004343
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004343
untagged cDNA clone in CMV expression vector: NM_004343

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004343

UniProtKB/Swiss-Prot: CALR_HUMAN, P27797

Function: Molecular calcium binding chaperone promoting folding, oligomeric assembly and quality

control in the ER via the calreticulin/calnexin cycle. This lectin interacts transiently with

almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with

the DNA-binding domain of NR3C1 and mediates its nuclear export

Genatlas biochemistry entry for CALR:

calreticulin,calcium binding protein of endoplasmic and sarcoplasmic reticulum,48kDa

8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Calr):

	cellular	embryogenesis	growth/size	homeostasis/metabolism
lethality-prenatal/perinatal	muscle	nervous system

5/11 Gene Ontology (GO) molecular function terms (links to tree view) (see all 11 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001849	complement component C1q binding	TAS	15474971
GO:0003677	DNA binding	NAS	11149926
GO:0003729	mRNA binding	IEA	--
GO:0005178	integrin binding	IPI	1911778
GO:0005509	calcium ion binding	TAS	11149926

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

4 Sigma-Aldrich "Your Favorite Gene" Pathways for CALR (Your Favorite Gene powered by Ingenuity)

Androgen Signaling
Calcium Signaling
Antigen Presentation Pathway
Lipid Antigen Presentation by CD1

GeneDecks CALR for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CALR

5/80 Interacting proteins for CALR (ENSP00000320866³ P27797^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 80 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PDIA3	P30101²	STRING (score=.998) MINT-16879 MINT-16517
CD40	P25942¹	EBI-1049597, EBI-525714
ELF3	P78545¹	EBI-1049597, EBI-1057285
EPB41	P11171¹	EBI-1049597, EBI-1050906
TAP1	Q03518¹	EBI-1049597, EBI-747259

About this table

5/21 Gene Ontology (GO) biological process terms (links to tree view) (see all 21 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA	8107809
GO:0002502	peptide antigen assembly with MHC class I protein complex	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	TAS	8107808
GO:0006611	protein export from nucleus	IDA	11149926
GO:0007050	cell cycle arrest	IGI	14726956

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CALR
10/46 Novoseek chemical compound relationships for CALR gene (see all 46 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
dolichyl diphosphate	77.14	1	10794707 (1)
calcium	55.38	237	9883279 (7), 8190118 (5), 10037706 (4), 8991101 (4) (see all 99)
mannose	46.68	2	11560994 (1), 17606910 (1)
inositol 1,4,5 trisphosphate	45.79	6	2103514 (1), 12407053 (1), 8381914 (1), 16291968 (1) (see all 6)
udpglucose	40.16	1	16154739 (1)
tetrasaccharide	39.22	2	12706973 (1), 12464625 (1)
ryanodine	38.34	11	9669316 (2), 7641356 (2), 2103514 (1), 17607358 (1) (see all 9)
aequorin	33.55	2	7985790 (1), 9883279 (1)
gliadin	29.75	5	9895374 (3), 7733929 (2)
exotoxin-a	27.80	4	14729651 (1), 14985791 (1), 16262727 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CALR)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CALR)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004343

Sigma-Aldrich siRNA for CALR

Sigma-Aldrich shRNA Panels and shRNA for CALR

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004343

REFSEQ mRNAs for CALR gene:

NM_004343.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004343

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004343
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004343
                                 untagged cDNA clone in CMV expression vector: NM_004343

Additional cDNA sequence:

AB451408.1 AF087986.1 AK130190.1 AK223060.1 AK304492.1 AY047586.1 BC002500.2 BC007911.1

BC020493.1 BC107102.2 BT007448.1 CR457070.1 CR590159.1 CR598365.1 CR604311.1 CR608681.1

CR613536.1 CR613586.1 CR619960.1 CR625160.1 M32294.1 M84739.1

24/57 DOTS entries (see all 57 ):

DT.85103834 DT.95368629 DT.100060029 DT.91793739 DT.91775612 DT.100691994 DT.91775621 DT.97760595

DT.121481239 DT.100692005 DT.100691979 DT.100692008 DT.86995148 DT.91959672 DT.100692003 DT.100691981

DT.101986489 DT.100691999 DT.121481190 DT.121481205 DT.121481251 DT.92326389 DT.100691997 DT.100852530

24/1816 AceView cDNA sequences (see all 1816 ):

CD519316 AI086532 BF915922 BU857185 AW189427 BM466469 BM791278 BM827500

BG117333 BF873845 AA156677 CA848513 BQ649496 CF142161 BU856979 BG230630

BM046860 BQ688828 BG491927 CN479594 BE876207 AU102712 BF869525 BQ679038

highest scoring ESTs for CALR:

M84739 AA026223 AA040723 AA046850 AA056743 AA062964 AA126398 AA152446 AA156983 AA159384

Unigene Cluster for CALR:

Calreticulin

Hs.515162 [show with all ESTs]

Unigene Representative Sequence: M84739

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CALR

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10a	·	10b
SP1:
SP2:									-
SP3:
SP4:

About this scheme

ECgene alternative splicing isoforms for CALR

1 Ensembl transcript including schematic representation:

ENST00000316448

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CALR expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CALR

¹ / ² / ³

8 probe-sets matching CALR gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32543_at²^{, 3}	U95-A	1	1.00	1.00	0.78	1.32	M84739	1.00	1.00	1.00	1
1752_at²^{, 3}	U95-A	1	1.00	1.00	0.97	0.71	AD000092	0.20	0.14	0.17	1
214315_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI348935	0.20	1.00	0.72	1
200935_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004343	0.60	1.00	0.82	1
212953_x_at²	U133-A	2	1.00	0.95	--	--	--	--	--	--	--
214315_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
200935_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212953_x_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

GeneDecks CALR for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCATCTTCAA

SOURCE GeneReport for Unigene cluster: Hs.515162
Expression variation in blood from EXPOLDB for CALR

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CALR gene from 5/18 species (see all 18 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CALR¹	--	calreticulin	89.64(n) 93.45(a)	476694 XM_533899.2 XP_533899.2
cow (Bos taurus)	CALR¹	--	calreticulin	89.1(n) 93.27(a)	281036 NM_174000.2 NP_776425.1
rat (Rattus norvegicus)	Calr¹	--	calreticulin	87.18(n) 93.99(a)	64202 NM_022399.1 NP_071794.1
mouse (Mus musculus)	Calr^{1, 5}	8 (37.00 cM)⁵	calreticulin^{1, 5}	87.5(n)¹ 94.47(a)¹	12317¹ NM_007591.3¹ NP_031617.1¹ AK075605⁵ AK136191⁵ (see all 78)
chicken (Gallus gallus)	CALR3¹	--	calreticulin 3	63.67(n) 60.85(a)	420146 XM_418262.2 XP_418262.2

About this table Species with no ortholog for CALR

ENSEMBL Gene Tree for CALR

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CALR gene

CLGN² CANX² CALR3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/39 NCBI SNPs in CALR are shown (see all 39 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 42)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1010222^1,2	A,C,F,H,O	12909608(+)	`TCCAGG/AAGTCA`	1	--	ng5¹		12		NA EU EA WA MN	2196
	rs11878305^1,2	A,C	12910280(+)	`CTAACA/CTAGTG`	1	--	ng5¹		0	--	--	--	--
--	rs11547568^1,2	H	12911291(+)	`AGTTTC/GGAGCC`	1	F/L	mis¹ ese³		4		EU EA WA	404
	rs28365950^1,2	F	12910415(+)	`GGCGGC/TGGCGT`	1	--	ut5¹ ese³		2		MN EA	1252
--	rs11547563^1,2	H	12912433(+)	`GAGAGT/GGGGAA`	1	G/W	mis¹		4		EU EA WA	406
	rs7250381^1,2	A,C,F,H	12911201(+)	`TCGCGA/GGTCAA`	1	--	int¹		4		EU EA WA	418
	rs7246836^1,2	F,H	12911090(+)	`GACTTC/GCTGGC`	1	--	int¹		4		EU EA WA	418
	rs10410152^1,2	H	12911170(+)	`GAGTCT/GTCTCT`	1	--	int¹		4		EU EA WA	418
--	rs11547567^1,2	--	12910473(+)	`GCGCGA/C/G/T TGCCG`	1	--	ut5¹ ese³		0	--	--	--	--
	rs28714580^1,2	--	12910299(+)	`AAGGTC/GCAATG`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for CALR (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 109091

10/59 Novoseek disease relationships for CALR gene (see all 59 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hepatitis halothane	56.98	2	11141678 (1), 8415876 (1)
congenital heart block	49.71	2	8904349 (1), 12601845 (1)
autoimmune response	46.72	3	9796851 (1), 1602002 (1), 10320638 (1)
sjogrens syndrome primary	45.41	4	7523671 (1), 8635291 (1), 2365822 (1)
onchocerciasis	45.09	9	1602002 (4), 7520419 (2), 7680295 (1), 7836063 (1) (see all 5)
shock	44.89	44	15383281 (3), 8676889 (3), 11328587 (2), 11290339 (2) (see all 35)
lupus erythematosus systemic	43.45	13	8050453 (2), 9302659 (2), 16081363 (1), 16645988 (1) (see all 10)
sjogrens syndrome	41.11	3	8478019 (1), 11480586 (1), 12410797 (1)
lupus erythematosus cutaneous subacute	39.90	2	8676889 (1), 7523671 (1)
lupus erythematosus	39.23	3	8676889 (1), 7523671 (1), 2365822 (1)

About this table

Human Gene Mutation Database: CALR

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/582 PubMed articles for CALR gene (see all 582 ):

A human Ro/SS-A autoantigen is the homologue of calreticulin and is highly homologous with onchocercal RAL-1 antigen and an aplysia "memory molecule". (PubMed id 2365822)^{1, 2, 3} McCauliffe D.P....Capra J.D. (1990)
Calreticulin is expressed on the cell surface of activated human peripheral blood T lymphocytes in association with major histocompatibility complex class I molecules. (PubMed id 10358038)^{1, 3, 4} Arosa F.A.... de Sousa M. (1999)
The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes. (PubMed id 8418194)^{1, 3, 4} Dupuis M.... Tschopp J. (1993)
The 5'-flanking region of the human calreticulin gene shares homology with the human GRP78, GRP94, and protein disulfide isomerase promoters. (PubMed id 1733953)^{1, 3, 4} McCauliffe D.P.... Capra J.D. (1992)
Characterization of the autoantigen calreticulin. (PubMed id 1919005)^{1, 3, 4} Rokeach L.A.... Hoch S.O. (1991)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{3, 4} Grimwood J.... Lucas S.M. (2004)
Calreticulin is a receptor for nuclear export. (PubMed id 11149926)^{3, 4} Holaska J.M....Paschal B.M. (2001)
Human placental calreticulin characterization of domain structure and post-translational modifications. (PubMed id 11322874)^{3, 4} Hoejrup P.... Houen G. (2001)
A two-dimensional gel database of human colon carcinoma proteins. (PubMed id 9150948)^{3, 4} Ji H.... Simpson R.J. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 811	HGNC: 1455	AceView: CALR	Ensembl:ENSG00000179218	euGenes: HUgn811
ECgene: CALR	H-InvDB: CALR

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CALR	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Calreticulin
Functional Glycomics Gateway - Glycan Binding	http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_other_405

Licensable Technologies for CALR
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CALR:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CALR-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CALR		Antibodies for CALR
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CALR		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CALR)
	Antibodies (CALR)
	Chimera RNAi (CALR)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for CALR (calreticulin)

	Recombinant Proteins (Calreticulin)
	Antibodies (Calreticulin)

Search OriGene for CALR

Search Tocris compounds for CALR

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CALR

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CALR Gene at Home site.
Version 2.41.1
server5.xennexinc.com

CALR Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for CALR

Summaries
for CALR

Genomic Location
for CALR

Proteins
for CALR

Protein Domains/
Families
for CALR

Gene Function
for CALR

Pathways & Interactions
for CALR

Drugs & Compounds
for CALR

Transcripts
for CALR

Expression
for CALR

Orthologs
for CALR

Paralogs
for CALR

SNPs/Variants
for CALR

Disorders & Mutations
for CALR

Medical News
for CALR

Publications
for CALR

Search for CALR

Genome Databases showing CALR

Other Databases showing CALR

Specialized Databases showing CALR

Licensable Technologies
for CALR

Services
for CALR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CALR Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor CALR

Summariesfor CALR

Genomic Locationfor CALR

Proteinsfor CALR

Protein Domains/Familiesfor CALR

Gene Functionfor CALR

Pathways & Interactionsfor CALR

Drugs & Compoundsfor CALR

Transcriptsfor CALR

Expression for CALR

Orthologsfor CALR

Paralogsfor CALR

SNPs/Variantsfor CALR

Disorders & Mutationsfor CALR

Medical Newsfor CALR

Publicationsfor CALR

Search for CALR

Genome Databases showing CALR

Other Databases showing CALR

Specialized Databases showing CALR

Licensable Technologiesfor CALR

Servicesfor CALR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CALR

Summaries
for CALR

Genomic Location
for CALR

Proteins
for CALR

Protein Domains/
Families
for CALR

Gene Function
for CALR

Pathways & Interactions
for CALR

Drugs & Compounds
for CALR

Transcripts
for CALR

Expression
for CALR

Orthologs
for CALR

Paralogs
for CALR

SNPs/Variants
for CALR

Disorders & Mutations
for CALR

Medical News
for CALR

Publications
for CALR

Licensable Technologies
for CALR

Services
for CALR