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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CALR Gene

protein-coding   GIFtS: 72
GCID: GC19P013049

Calreticulin

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
calreticulin1 2     Autoantigen Ro1
Sicca Syndrome Antigen A (Autoantigen Ro; Calreticulin)1 2     CRT2
Endoplasmic Reticulum Resident Protein 602 3     RO2
CRP552 3     cC1qR2
ERp602 3     calregulin2
HACBP2 3     CRTC3
grp602 3     Calregulin3
SSA2 5     

External Ids:    HGNC: 14551   Entrez Gene: 8112   Ensembl: ENSG000001792187   OMIM: 1090915   UniProtKB: P277973   

Export aliases for CALR gene to outside databases

Previous GC identifers: GC19P013180 GC19P013272 GC19P012894 GC19P012910 GC19P012621


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CALR Gene:
Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of
the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription
regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid
sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in
certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved
among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The
amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents
the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding
of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid
receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus,
calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone
receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but
calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was
later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete
congenital heart block of both the IgG and IgM classes. (provided by RefSeq, Jul 2008)

GeneCards Summary for CALR Gene: 
CALR (calreticulin) is a protein-coding gene. Diseases associated with CALR include congenital heart block, and breast mucinous carcinoma, and among its related super-pathways are WNT ligand biogenesis and trafficking and N-glycan trimming in the ER and Calnexin/Calreticulin cycle. GO annotations related to this gene include iron ion binding and calcium ion binding. An important paralog of this gene is CLGN.

UniProtKB/Swiss-Prot: CALR_HUMAN, P27797
Function: Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the
endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all
of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of
NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte
maturation via the regulation of calcium homeostasis (By similarity)

Gene Wiki entry for CALR (Calreticulin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CALR gene promoter:
         AP-1   p53   ATF-2   CUTL1   Nkx2-5   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CALR promoter sequence
   Search SABiosciences Chromatin IP Primers for CALR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CALR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3-p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.3-p13.2

CALR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALR gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P013049:  view genomic region     (about GC identifiers)

Start:
13,049,392 bp from pter      End:
13,055,304 bp from pter
Size:
5,913 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CALR_HUMAN, P27797 (See protein sequence)
Recommended Name: Calreticulin precursor  
Size: 417 amino acids; 48142 Da
Subunit: Monomer. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2,
HSP90B1 and HSPA5. Interacts with PDIA3/ERp57 (By similarity). Interacts with NR3C1 and TRIM21. Interacts with
GABARAP
Subcellular location: Endoplasmic reticulum lumen. Cytoplasm, cytosol. Secreted, extracellular space,
extracellular matrix. Cell surface. Sarcoplasmic reticulum lumen (By similarity). Note=Also found in cell surface
(T cells), cytosol and extracellular matrix. Associated with the lytic granules in the cytolytic T-lymphocytes
Mass spectrometry: Mass=46879; Method=MALDI; Range=18-417; Source=PubMed:11149926;
Caution: Was originally (PubMed:2332496) thought to be the 52 kDa Ro autoantigen
4 PDB 3D structures from and Proteopedia for CALR:
2CLR (3D)        3DOW (3D)        3POS (3D)        3POW (3D)    
Secondary accessions: Q6IAT4 Q9UDG2

Explore the universe of human proteins at neXtProt for CALR: NX_P27797

Explore proteomics data for CALR at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P27797

  • CALR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CALR Protein Expression
    REFSEQ proteins: NP_004334.1  
    ENSEMBL proteins: 
     ENSP00000320866   ENSP00000465105   ENSP00000465918   ENSP00000466037  
    Reactome Protein details: P27797
    Human Recombinant Protein Products for CALR: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for CALR
    OriGene Purified Protein for CALR
    OriGene Protein Over-expression Lysate for CALR
    OriGene MassSpec for CALR 
    OriGene Custom Protein Services for CALR
    GenScript Custom Purified and Recombinant Proteins Services for CALR
    Novus Biologicals CALR Proteins
    Novus Biologicals CALR Lysates
    Sino Biological Recombinant Protein for CALR
    Sino Biological Cell Lysate for CALR 
    ProSpec Recombinant Protein for CALR
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/22 cellular component terms (GO ID links to tree view) (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IDA--
    GO:0005622intracellular TAS7841019

    CALR for ontologies           About GeneDecksing



    CALR Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CALR
    R&D Systems Antibodies for CALR (Calreticulin)
    Cell Signaling Technology (CST) Antibodies for CALR  (calreticulin)
    OriGene Antibodies for CALR
    OriGene Custom Antibody Services for CALR
    GenScript Superior Antibodies for CALR
    Novus Biologicals CALR Antibodies
    Abcam antibodies for CALR
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for CALR
    LSBio Antibodies in human, mouse, rat for CALR 

    Assay Products for CALR: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CALR
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CALR
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR018124 Calret/calnex_CS
     IPR013320 ConA-like_subgrp
     IPR009169 Calreticulin
     IPR001580 Calret/calnex
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry P27797

    ProtoNet protein and cluster: P27797

    1 Blocks protein domain: IPB001580 Calreticulin

    UniProtKB/Swiss-Prot: CALR_HUMAN, P27797
    Domain: Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like
    structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas
    the acidic C-domain binds multiple calcium ions with low affinity
    Domain: The interaction with glycans occurs through a binding site in the globular lectin domain
    Domain: The zinc binding sites are localized to the N-domain
    Domain: Associates with PDIA3 through the tip of the extended arm formed by the P-domain
    Similarity: Belongs to the calreticulin family


    CALR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CALR_HUMAN, P27797
    Function: Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the
    endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all
    of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of
    NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte
    maturation via the regulation of calcium homeostasis (By similarity)

         Genatlas biochemistry entry for CALR:
    calreticulin,calcium binding protein of endoplasmic and sarcoplasmic reticulum,48kDa

         Gene Ontology (GO): 5/16 molecular function terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001849complement component C1q binding TAS15474971
    GO:0003677DNA binding NAS11149926
    GO:0003729mRNA binding IDA14726956
    GO:0005178integrin binding IPI1911778
    GO:0005506iron ion binding IEA--
         
    CALR for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CALR:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Calr):
     cardiovascular system  cellular  embryogenesis  growth/size  homeostasis/metabolism 
     mortality/aging  muscle  nervous system 

    CALR for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CALR: Calrtm1Star Calrtm1Mlk

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CALR 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CALR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CALR 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CALR 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALR
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate CALR (see all 21):
    hsa-miR-875-3p hsa-miR-181c hsa-miR-512-3p hsa-miR-650 hsa-miR-633 hsa-miR-637 hsa-miR-3116 hsa-miR-2116
    SwitchGear 3'UTR luciferase reporter plasmidCALR 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CALR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CALR
    Sirion Biotech Customized adenovirus for overexpression of CALR

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CALR (see all 7)
    OriGene ORF clones in mouse, rat for CALR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CALR (NM_004343)
    Sino Biological Human cDNA Clone for CALR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALR
    Sirion Biotech Customized lentivirus for stable overexpression of CALR 
                         Customized lentivirus expression plasmids for stable overexpression of CALR 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CALR
    Search LifeMap BioReagents cell lines for CALR
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALR


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CALR About   (see all 25)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Asparagine N-linked glycosylation
    Asparagine N-linked glycosylation0.77
    Post-translational protein modification0.44
    WNT ligand biogenesis and trafficking0.77
    Metabolism of proteins0.35
    Signaling by Wnt0.62
    2Calnexin/calreticulin cycle
    Calnexin/calreticulin cycle0.85
    N-glycan trimming in the ER and Calnexin/Calreticulin cycle0.85
    3CDK-mediated phosphorylation and removal of Cdc6
    ER-Phagosome pathway0.81
    Antigen processing-Cross presentation0.81
    4Activation of Chaperone Genes by ATF6-alpha
    Activation of Chaperone Genes by ATF6-alpha0.62
    Activation of Chaperones by ATF6-alpha0.62
    5Immune System
    Immune System0.56
    Adaptive Immune System0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for CALR
        Immune response Antigen presentation by MHC class I
    Transcription Role of VDR in regulation of genes involved in osteoporosis

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CALR
        Androgen Signaling
    Presenilin-Mediated Signaling

    2 Cell Signaling Technology (CST) Pathways for CALR
        Ca, cAMP and Lipid Signaling
    Neuroscience

    2 GeneGo (Thomson Reuters) Pathways for CALR
        Immune response Antigen presentation by MHC class I
    Transcription Role of VDR in regulation of genes involved in osteoporosis

    2 BioSystems Pathways for CALR
        Calcium Regulation in the Cardiac Cell
    Androgen receptor signaling pathway


    5/20        Reactome Pathways for CALR (see all 20)
        Antigen Presentation: Folding, assembly and peptide loading of class I MHC
    Calnexin/calreticulin cycle
    ER-Phagosome pathway
    Signal Transduction
    Activation of Chaperones by ATF6-alpha


    5         Kegg Pathways  (Kegg details for CALR):
        Protein processing in endoplasmic reticulum
    Phagosome
    Antigen processing and presentation
    Chagas disease (American trypanosomiasis)
    HTLV-I infection


    CALR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CALR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/123 Interacting proteins for CALR (P277971, 2, 3 ENSP000003208664) via UniProtKB, MINT, STRING, and/or I2D (see all 123)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000227816Q035181, 3, ENSP000004011494EBI-1049597,EBI-747259 I2D: score=2 STRING: ENSP00000401149
    ENSG00000206297Q035181, 3EBI-1049597,EBI-747259 I2D: score=2 
    ENSG00000224212Q035181, 3EBI-1049597,EBI-747259 I2D: score=2 
    ENSG00000226173Q035181, 3EBI-1049597,EBI-747259 I2D: score=2 
    ENSG00000230705Q035181, 3EBI-1049597,EBI-747259 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/44 biological process terms (GO ID links to tree view) (see all 44):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA8107809
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--
    GO:0002502peptide antigen assembly with MHC class I protein complex ISS11825569
    GO:0006355regulation of transcription, DNA-dependent TAS8107808

    CALR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CALR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CALR

    1 HMDB Compound for CALR    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    3 DrugBank Compounds for CALR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Antihemophilic FactorAHF (see all 3)--targetchaperone9607108 9525969 17139284 17899080 17016423
    MelatoninMEL (see all 4)73-31-4target--12603316 19449447
    Tenecteplaset- PA (see all 4)191588-94-0target--9359841

    10/77 Novoseek inferred chemical compound relationships for CALR gene (see all 77)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    castanospermine 80.1 4 12740382 (1), 7657600 (1), 9348535 (1), 12623072 (1)
    dolichyl diphosphate 76.4 1 10794707 (1)
    kifunensine 60 1 12623072 (1)
    tunicamycin 58.4 6 15383281 (1), 9207473 (1), 9367877 (1), 14744598 (1) (see all 5)
    calcium 55 249 9883279 (7), 8190118 (5), 10037706 (4), 8991101 (4) (see all 99)
    polysaccharide 53.4 29 18803404 (3), 19959473 (3), 9348279 (2), 16039588 (2) (see all 22)
    thapsigargin 48.2 8 14744598 (2), 12401114 (1), 8809046 (1), 10353723 (1) (see all 6)
    mannose 44.6 2 11560994 (1), 17606910 (1)
    inositol 1,4,5 trisphosphate 44.3 6 2103514 (1), 12407053 (1), 8381914 (1), 16291968 (1) (see all 6)
    udpglucose 41.9 2 16154739 (1), 19822453 (1)

    Search CenterWatch for drugs/clinical trials and news about CALR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CALR gene: 
    NM_004343.3  

    Unigene Cluster for CALR:

    Calreticulin
    Hs.515162  [show with all ESTs]
    Unigene Representative Sequence: M84739
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000587486 ENST00000316448(uc002mvu.2) ENST00000590325 ENST00000588454
    ENST00000586760 ENST00000586803 ENST00000586967
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate CALR (see all 21):
    hsa-miR-875-3p hsa-miR-181c hsa-miR-512-3p hsa-miR-650 hsa-miR-633 hsa-miR-637 hsa-miR-3116 hsa-miR-2116
    SwitchGear 3'UTR luciferase reporter plasmidCALR 3' UTR sequence
    Inhib. RNA
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    Clone
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    OriGene ORF clones in mouse, rat for CALR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CALR (NM_004343)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALR
    Sirion Biotech Customized lentivirus for stable overexpression of CALR 
                         Customized lentivirus expression plasmids for stable overexpression of CALR 
    Primer
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    OriGene qPCR primer pairs and template standards for CALR
    OriGene qSTAR qPCR primer pairs in human, mouse for CALR
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CALR
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALR
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALR

    Additional mRNA sequence: 

    AB451408.1 AF087986.1 AK130190.1 AK223060.1 AK304492.1 AY047586.1 BC002500.2 BC007911.1 
    BC020493.1 BC107102.2 BT007448.1 CR457070.1 M32294.1 M84739.1 

    24/57 DOTS entries (see all 57):

    DT.85103834  DT.95368629  DT.100060029  DT.91793739  DT.91775612  DT.100691994  DT.91775621  DT.97760595 
    DT.121481239  DT.100692005  DT.100691979  DT.100692008  DT.86995148  DT.100692003  DT.100691981  DT.91959672 
    DT.101986489  DT.100691999  DT.121481190  DT.121481205  DT.121481251  DT.100691997  DT.121643184  DT.100852530 

    24/1816 AceView cDNA sequences (see all 1816):

    BQ439614 AU123482 BM970404 BQ723375 BM451986 CD519316 BM848245 CR598365 
    BU857939 BQ893120 N27068 AW845193 BQ447723 BE261066 AI870689 BU931170 
    BU552843 BE674130 AA156229 BE140529 AI206110 BQ681869 AI751530 BG675100 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CALR    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
    SP1:                                                                                    
    SP2:                          -                                                         
    SP3:                                                                                    
    SP4:                                                                                    


    ECgene alternative splicing isoforms for CALR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CALR expression in normal human tissues (normalized intensities)      CALR embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCATCTTCAA
    CALR Expression
    About this image


    CALR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Double Negative 2 Thymocytes Thymus
             Bone marrow-derived hematopoietic stem cells
     
     Intestine (Gastrointestinal Tract)
             SMALL INTESTINE   
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...

    See CALR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CALR

    SOURCE GeneReport for Unigene cluster: Hs.515162
        SABiosciences Expression via Pathway-Focused PCR Arrays including CALR (see all 7): 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Cellular Senescence in human mouse rat
              Cellular Stress Responses in human mouse rat
              Unfolded Protein Response in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CALR gene from 10/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Calr1 , 5 calreticulin1, 5 87.58(n)1
    94.47(a)1
      8 (41.21 cM)5
    123171  NM_007591.31  NP_031617.11 
     848418505 
    chicken
    (Gallus gallus)
    Aves CALR31 calreticulin 3 63.76(n)
    60.85(a)
      420146  XM_418262.3  XP_418262.2 
    lizard
    (Anolis carolinensis)
    Reptilia CALR6
    Uncharacterized protein
    80(a)
    1 ↔ 1
    2(77770708-77779899)
    African clawed frog
    (Xenopus laevis)
    Amphibia calr-prov2 calreticulin 76.16(n)    BC046699.1 
    zebrafish
    (Danio rerio)
    Actinopterygii calr2 calreticulin 77.59(n)   30248  BC058314.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Crc1 , 3 central nervous system development
    calcium ion more3
    Calreticulin1
    70(a)3
    68(n)1
    67.42(a)1
      3 85E13
    411661  NM_079569.41  NP_524293.21 
    worm
    (Caenorhabditis elegans)
    Secernentea crt-11 , 3 calreticulin precursor3
    Protein CRT-11
    66(a)3
    66.67(n)1
    64.58(a)1
      V(6101766-6103103)3
    1789971  NM_072174.21  NP_504575.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CNE16
    Calnexin; integral membrane ER chaperone involved ...
    21(a)
    1 → many
    I(37464-38972)
    Alicante grape
    (Vitis vinifera)
    eudicotyledons Vvi.15642 Vitis vinifera transcribed sequence with moderate similarity more 76.68(n)    CB346544.2 
    rice
    (Oryza sativa)
    Liliopsida Os.71582 Oryza sativa mRNA for calcium-binding protein, complete more 77.05(n)    AK099348.1 


    ENSEMBL Gene Tree for CALR (if available)
    TreeFam Gene Tree for CALR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CALR gene
    CLGN2  CALR32  CANX2  
    2 SIMAP similar genes for CALR using alignment to 5 protein entries:     CALR_HUMAN (see all proteins):
    CALR3    CLGN

    CALR for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CALR
    PGOHUM00000244024


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/276 SNPs in CALR are shown (see all 276)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1409587461,2
    C--12984366(+) CAGGCA/GTGAGC 1 -- us2k10--------
    rs741816821,2
    C--12984394(+) TTTTAG/TTTAAT 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs735053591,2
    C,F--12984536(+) GGAAGC/TGCCAA 1 -- us2k13Minor allele frequency- T:0.26WA CSA 122
    rs735053601,2
    C,F--12984587(+) CAAGAG/TGCCTG 1 -- us2k13Minor allele frequency- T:0.25WA CSA 122
    rs1823416401,2
    --12984802(+) CGATTC/TTCCCA 1 -- us2k10--------
    rs1122826501,2
    C,F--12984822(+) CCCGAG/ATACTG 1 -- us2k13Minor allele frequency- A:0.26WA CSA 122
    rs739252371,2
    C,F--12985160(+) ATCCCC/TCTCAT 1 -- us2k13Minor allele frequency- T:0.11WA CSA 122
    rs735053631,2
    C,F--12985304(+) GCTTCT/AGAAGA 1 -- us2k13Minor allele frequency- A:0.28WA CSA 122
    rs10102221,2
    C,F,O,A,H--12985555(+) TCCAGG/AAGTCA 1 -- us2k134Minor allele frequency- A:0.21NA NS EA MN WA CSA 4131
    rs1389578941,2
    --12985676(+) GGAACA/GTCTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CALR (13049392 - 13055304 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CALR:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv911082CNV Loss21882294
    nsv911085CNV Loss21882294
    nsv833754CNV Loss17160897


    Human Gene Mutation Database (HGMD): CALR
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for CALR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 109091    OMIM disorders: --

    20/94 diseases for CALR (see all 94):    About MalaCards
    congenital heart block    breast mucinous carcinoma    lupus erythematosus    rubella
    al amyloidosis    malignant hyperthermia susceptibility    malignant hyperthermia    catecholaminergic polymorphic ventricular tachycardia
    chagas disease    onchocerciasis    intestinal volvulus    dedifferentiated liposarcoma
    sialadenitis    rheumatic disease    systemic lupus erythematosus    dry eye syndrome
    achalasia    bladder transitional cell carcinoma    hemochromatosis    sjogren's syndrome

    3 diseases from the University of Copenhagen DISEASES database for CALR:
    Cancer     Onchocerciasis     Lupus erythematosus

    CALR for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/60 Novoseek inferred disease relationships for CALR gene (see all 60)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis halothane 55.7 2 11141678 (1), 8415876 (1)
    congenital heart block 52.8 3 8904349 (1), 12601845 (1), 19886247 (1)
    autoimmune response 46.9 3 9796851 (1), 1602002 (1), 10320638 (1)
    shock 45 47 15383281 (3), 8676889 (3), 11328587 (2), 11290339 (2) (see all 38)
    sjogrens syndrome primary 44.4 3 8635291 (1), 2365822 (1)
    onchocerciasis 43.5 9 1602002 (4), 7520419 (2), 7680295 (1), 7836063 (1) (see all 5)
    lupus erythematosus systemic 41.3 13 8050453 (2), 9302659 (2), 16081363 (1), 16645988 (1) (see all 10)
    sjogrens syndrome 40.1 3 8478019 (1), 11480586 (1), 12410797 (1)
    complete heart block 33.1 1 16546685 (1)
    lupus erythematosus 32.7 2 8676889 (1), 2365822 (1)

    Genetic Association Database (GAD): CALR
    Human Genome Epidemiology (HuGE) Navigator: CALR (3 documents)

    Export disorders for CALR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CALR gene, integrated from 9 sources (see all 728):
    (articles sorted by number of sources associating them with CALR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human Ro/SS-A autoantigen is the homologue of calreticulin and is highly homologous with onchocercal RAL-1 antigen and an aplysia 'memory molecule'. (PubMed id 2365822)1, 3, 9 McCauliffe D.P....Capra J.D. (1990)
    2. Calreticulin is expressed on the cell surface of activated human peripheral blood T lymphocytes in association with major histocompatibility complex class I molecules. (PubMed id 10358038)1, 2, 9 Arosa F.A.... de Sousa M. (1999)
    3. Calnexin and calreticulin bind to enzymically active tissue-type plasminogen activator during biosynthesis and are not required for folding to the native conformation. (PubMed id 9359841)1, 7, 9 Allen S. and Bulleid N.J. (1997)
    4. The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes. (PubMed id 8418194)1, 2, 9 Dupuis M.... Tschopp J. (1993)
    5. Calreticulin binds hYRNA and the 52-kDa polypeptide component of the Ro/SS-A ribonucleoprotein autoantigen. (PubMed id 8666824)1, 2, 9 Cheng S.T....Sontheimer R.D. (1996)
    6. Human placental calreticulin: purification, characterization and association with other proteins. (PubMed id 7841019)1, 2, 9 Houen G. and Koch C. (1994)
    7. The 5'-flanking region of the human calreticulin gene shares homology with the human GRP78, GRP94, and protein disulfide isomerase promoters. (PubMed id 1733953)1, 2, 9 McCauliffe D.P.... Capra J.D. (1992)
    8. Characterization of the autoantigen calreticulin. (PubMed id 1919005)1, 2, 9 Rokeach L.A.... Hoch S.O. (1991)
    9. X-ray structure of the human calreticulin globular domain reveals a peptide-binding area and suggests a multi-molecular mechanism. (PubMed id 21423620)1, 2 Chouquet A.... Gaboriaud C. (2011)
    10. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 811 HGNC: 1455 AceView: CALR Ensembl:ENSG00000179218 euGenes: HUgn811
    ECgene: CALR Kegg: 811 H-InvDB: CALR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CALR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CALR Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Calreticulin
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_other_405

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CALR gene:
    Search GeneIP for patents involving CALR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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