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CALR Gene

protein-coding   GIFtS: 73
GCID: GC19P013049

Calreticulin

  See CALR-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
calreticulin1 2     CRT2
Sicca Syndrome Antigen A (Autoantigen Ro; Calreticulin)1 2     HEL-S-99n2
Endoplasmic Reticulum Resident Protein 602 3     RO2
CRP552 3     cC1qR2
ERp602 3     calregulin2
HACBP2 3     Epididymis Secretory Sperm Binding Protein Li 99n2
grp602 3     CRTC3
SSA2 5     Calregulin3
Autoantigen Ro1     

External Ids:    HGNC: 14551   Entrez Gene: 8112   Ensembl: ENSG000001792187   OMIM: 1090915   UniProtKB: P277973   

Export aliases for CALR gene to outside databases

Previous GC identifers: GC19P013180 GC19P013272 GC19P012894 GC19P012910 GC19P012621


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CALR Gene:
Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of
the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription
regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid
sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in
certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved
among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The
amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents
the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding
of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid
receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus,
calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone
receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but
calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was
later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete
congenital heart block of both the IgG and IgM classes. (provided by RefSeq, Jul 2008)

GeneCards Summary for CALR Gene:
CALR (calreticulin) is a protein-coding gene. Diseases associated with CALR include thrombocythemia, somatic, and breast mucinous carcinoma. GO annotations related to this gene include iron ion binding and calcium ion binding. An important paralog of this gene is CLGN.

UniProtKB/Swiss-Prot: CALR_HUMAN, P27797
Function: Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the
endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all
of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of
NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte
maturation via the regulation of calcium homeostasis (By similarity)

Gene Wiki entry for CALR (Calreticulin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the CALR gene promoter:
         AP-1   p53   ATF-2   CUTL1   Nkx2-5   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CALR promoter sequence
   Search Chromatin IP Primers for CALR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CALR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3-p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.3-p13.2

CALR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALR gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P013049:  view genomic region     (about GC identifiers)

Start:
13,049,392 bp from pter      End:
13,055,304 bp from pter
Size:
5,913 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CALR_HUMAN, P27797 (See protein sequence)
Recommended Name: Calreticulin precursor  
Size: 417 amino acids; 48142 Da
Subunit: Monomer. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2,
HSP90B1 and HSPA5. Interacts with PDIA3/ERp57 (By similarity). Interacts with NR3C1 and TRIM21. Interacts with
GABARAP
Mass spectrometry: Mass=46879; Method=MALDI; Range=18-417; Source=PubMed:11149926;
Caution: Was originally (PubMed:2332496) thought to be the 52 kDa Ro autoantigen
4 PDB 3D structures from and Proteopedia for CALR:
2CLR (3D)        3DOW (3D)        3POS (3D)        3POW (3D)    
Secondary accessions: Q6IAT4 Q9UDG2

Explore the universe of human proteins at neXtProt for CALR: NX_P27797

Explore proteomics data for CALR at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys24, Lys48, Lys55, Lys159
  • Glycosylation2 at Asn344
  • Modification sites at PhosphoSitePlus

  • See CALR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004334.1  
    ENSEMBL proteins: 
     ENSP00000320866   ENSP00000465105   ENSP00000465918   ENSP00000466037  
    Reactome Protein details: P27797

    CALR Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for CALR
    OriGene Purified Protein for CALR
    OriGene Protein Over-expression Lysate for CALR
    OriGene MassSpec for CALR
    OriGene Custom Protein Services for CALR
    GenScript Custom Purified and Recombinant Proteins Services for CALR
    Novus Biologicals CALR Proteins
    Novus Biologicals CALR Lysates
    Sino Biological Recombinant Protein for CALR
    Sino Biological Cell Lysate for CALR
    ProSpec Recombinant Protein for CALR
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CALR 

    CALR Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CALR
    R&D Systems Antibodies for CALR (Calreticulin)
    Cell Signaling Technology (CST) Antibodies for CALR  (calreticulin)
    OriGene Antibodies for CALR
    OriGene Custom Antibody Services for CALR
    Novus Biologicals CALR Antibodies
    Abcam antibodies for CALR
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for CALR
    LSBio Antibodies in human, mouse, rat for CALR

    CALR Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CALR
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CALR
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CALR 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR018124 Calret/calnex_CS
     IPR013320 ConA-like_subgrp
     IPR009033 Calreticulin/calnexin_P_dom
     IPR009169 Calreticulin
     IPR001580 Calret/calnex

    Graphical View of Domain Structure for InterPro Entry P27797

    ProtoNet protein and cluster: P27797

    1 Blocks protein domain: IPB001580 Calreticulin

    UniProtKB/Swiss-Prot: CALR_HUMAN, P27797
    Domain: Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like
    structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas
    the acidic C-domain binds multiple calcium ions with low affinity
    Domain: The interaction with glycans occurs through a binding site in the globular lectin domain
    Domain: The zinc binding sites are localized to the N-domain
    Domain: Associates with PDIA3 through the tip of the extended arm formed by the P-domain
    Similarity: Belongs to the calreticulin family


    Find genes that share domains with CALR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CALR_HUMAN, P27797
    Function: Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the
    endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all
    of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of
    NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte
    maturation via the regulation of calcium homeostasis (By similarity)

         Genatlas biochemistry entry for CALR:
    calreticulin,calcium binding protein of endoplasmic and sarcoplasmic reticulum,48kDa

         Gene Ontology (GO): Selected molecular function terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001849complement component C1q binding TAS15474971
    GO:0001948glycoprotein binding IEA--
    GO:0003677DNA binding NAS11149926
    GO:0003729mRNA binding IDA14726956
    GO:0005178integrin binding IPI1911778
         
    Find genes that share ontologies with CALR           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CALR:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Calr):
     cardiovascular system  cellular  embryogenesis  growth/size/body  homeostasis/metabolism 
     mortality/aging  muscle  nervous system 

    Find genes that share phenotypes with CALR           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CALR: Calrtm1Star Calrtm1Mlk

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CALR
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CALR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CALR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CALR

    miRNA
    Products:
        
    miRTarBase miRNAs that target CALR:
    hsa-mir-320a (MIRT044537), hsa-mir-122-5p (MIRT023227), hsa-mir-423-3p (MIRT042481), hsa-mir-16-5p (MIRT031457), hsa-mir-149-5p (MIRT045548), hsa-mir-1 (MIRT023576), hsa-mir-124-3p (MIRT022337)

    Block miRNA regulation of human, mouse, rat CALR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CALR (see all 21):
    hsa-miR-875-3p hsa-miR-181c hsa-miR-512-3p hsa-miR-650 hsa-miR-633 hsa-miR-637 hsa-miR-3116 hsa-miR-2116
    SwitchGear 3'UTR luciferase reporter plasmidCALR 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CALR
    Predesigned siRNA for gene silencing in human, mouse, rat CALR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CALR

    Clone
    Products:
         
    OriGene clones in human, mouse for CALR (see all 7)
    OriGene ORF clones in mouse, rat for CALR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CALR (NM_004343)
    Sino Biological Human cDNA Clone for CALR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALR

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CALR
    Browse ESI BIO Cell Lines and PureStem Progenitors for CALR 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CALR_HUMAN, P27797: Endoplasmic reticulum lumen. Cytoplasm, cytosol. Secreted, extracellular space,
    extracellular matrix. Cell surface. Sarcoplasmic reticulum lumen (By similarity). Note=Also found in cell surface
    (T cells), cytosol and extracellular matrix. Associated with the lytic granules in the cytolytic T-lymphocytes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    endoplasmic reticulum5
    extracellular5
    nucleus4
    cytoskeleton2
    golgi apparatus2
    mitochondrion2
    plasma membrane2
    lysosome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IDA--
    GO:0005622intracellular TAS7841019

    Find genes that share ontologies with CALR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CALR About   (see all 21)  
    See pathways by source

    SuperPathContained pathways About
    1CDK-mediated phosphorylation and removal of Cdc6
    ER-Phagosome pathway0.80
    Immune response Antigen presentation by MHC class I0.68
    Antigen processing-Cross presentation0.80
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Asparagine N-linked glycosylation0.49
    Calnexin/calreticulin cycle0.00
    Post-translational protein modification0.43
    N-glycan trimming in the ER and Calnexin/Calreticulin cycle0.00
    Metabolism of proteins0.30
    3Unfolded Protein Response
    Unfolded Protein Response0.61
    Activation of Chaperone Genes by ATF6-alpha0.00
    Activation of Chaperones by ATF6-alpha0.00
    4Binding and Uptake of Ligands by Scavenger Receptors
    Binding and Uptake of Ligands by Scavenger Receptors0.53
    Scavenging by Class A Receptors0.00
    Scavenging by Class F Receptors0.00
    5Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41


    Find genes that share SuperPaths with CALR           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CALR
        Androgen Signaling
    Presenilin-Mediated Signaling

    2 Cell Signaling Technology (CST) Pathways for CALR
        Ca, cAMP and Lipid Signaling
    Neuroscience

    2 GeneGo (Thomson Reuters) Pathways for CALR
        Immune response Antigen presentation by MHC class I
    Transcription Role of VDR in regulation of genes involved in osteoporosis

    2 BioSystems Pathways for CALR
        Calcium Regulation in the Cardiac Cell
    Androgen receptor signaling pathway


    Selected Reactome Pathways for CALR (see all 7)
        Assembly of Viral Components at the Budding Site
    Antigen Presentation: Folding, assembly and peptide loading of class I MHC
    Scavenging by Class A Receptors
    Scavenging by Class F Receptors
    Calnexin/calreticulin cycle


    5 Kegg Pathways  (Kegg details for CALR):
        Protein processing in endoplasmic reticulum
    Phagosome
    Antigen processing and presentation
    Chagas disease (American trypanosomiasis)
    HTLV-I infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CALR (see all 7): 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Cellular Senescence in human mouse rat
              Cellular Stress Responses in human mouse rat
              Unfolded Protein Response in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CALR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CALR (P277971, 2, 3 ENSP000003208664) via UniProtKB, MINT, STRING, and/or I2D (see all 198)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000227816Q035181, 3, ENSP000004011494EBI-1049597,EBI-747259 I2D: score=2 STRING: ENSP00000401149
    ENSG00000206297Q035181, 3EBI-1049597,EBI-747259 I2D: score=2 
    ENSG00000224212Q035181, 3EBI-1049597,EBI-747259 I2D: score=2 
    ENSG00000226173Q035181, 3EBI-1049597,EBI-747259 I2D: score=2 
    ENSG00000230705Q035181, 3EBI-1049597,EBI-747259 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 45):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA8107809
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--
    GO:0002502peptide antigen assembly with MHC class I protein complex ISS11825569
    GO:0006355regulation of transcription, DNA-templated TAS8107808

    Find genes that share ontologies with CALR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CALR

    1 HMDB Compound for CALR    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    3 DrugBank Compounds for CALR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Antihemophilic FactorAHF (see all 3)--targetchaperone9607108 9525969 17139284 17899080 17016423
    MelatoninMEL (see all 4)73-31-4target--12603316 19449447
    Tenecteplaset- PA (see all 4)191588-94-0target--9359841

    Selected Novoseek inferred chemical compound relationships for CALR gene (see all 77)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    castanospermine 80.1 4 12740382 (1), 7657600 (1), 9348535 (1), 12623072 (1)
    dolichyl diphosphate 76.4 1 10794707 (1)
    kifunensine 60 1 12623072 (1)
    tunicamycin 58.4 6 15383281 (1), 9207473 (1), 9367877 (1), 14744598 (1) (see all 5)
    calcium 55 249 9883279 (7), 8190118 (5), 10037706 (4), 8991101 (4) (see all 99)
    polysaccharide 53.4 29 18803404 (3), 19959473 (3), 9348279 (2), 16039588 (2) (see all 22)
    thapsigargin 48.2 8 14744598 (2), 12401114 (1), 8809046 (1), 10353723 (1) (see all 6)
    mannose 44.6 2 11560994 (1), 17606910 (1)
    inositol 1,4,5 trisphosphate 44.3 6 2103514 (1), 12407053 (1), 8381914 (1), 16291968 (1) (see all 6)
    udpglucose 41.9 2 16154739 (1), 19822453 (1)



    Find genes that share compounds with CALR           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CALR gene: 
    NM_004343.3  

    Unigene Cluster for CALR:

    Calreticulin
    Hs.515162  [show with all ESTs]
    Unigene Representative Sequence: M84739
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000587486 ENST00000316448(uc002mvu.2) ENST00000590325 ENST00000588454
    ENST00000586760 ENST00000586803 ENST00000586967
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CALR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CALR (see all 21):
    hsa-miR-875-3p hsa-miR-181c hsa-miR-512-3p hsa-miR-650 hsa-miR-633 hsa-miR-637 hsa-miR-3116 hsa-miR-2116
    SwitchGear 3'UTR luciferase reporter plasmidCALR 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CALR
    Predesigned siRNA for gene silencing in human, mouse, rat CALR
    Clone
    Products:
         
    OriGene clones in human, mouse for CALR (see all 7)
    OriGene ORF clones in mouse, rat for CALR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CALR (NM_004343)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALR
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CALR
    OriGene qSTAR qPCR primer pairs in human, mouse for CALR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CALR
      QuantiTect SYBR Green Assays in human, mouse, rat CALR
      QuantiFast Probe-based Assays in human, mouse, rat CALR

    Additional mRNA sequence: 

    AB451408.1 AF087986.1 AK130190.1 AK223060.1 AK304492.1 AY047586.1 BC002500.2 BC007911.1 
    BC020493.1 BC107102.2 BT007448.1 CR457070.1 M32294.1 M84739.1 

    Selected DOTS entries (see all 57):

    DT.85103834  DT.95368629  DT.100060029  DT.91793739  DT.91775612  DT.100691994  DT.91775621  DT.97760595 
    DT.121481239  DT.100692005  DT.100691979  DT.100692008  DT.86995148  DT.100692003  DT.100691981  DT.91959672 
    DT.101986489  DT.100691999  DT.121481190  DT.121481205  DT.121481251  DT.100691997  DT.121643184  DT.100852530 

    Selected AceView cDNA sequences (see all 1816):

    BU956409 AW802656 BQ677815 BG164805 BE550704 BG251507 BE298152 BU728432 
    BU552697 BU176270 BU538925 AI826625 BM997560 BM543405 AI131411 H99170 
    BU845261 BU932032 BE313760 BM468741 CB216406 AI348648 AI803801 AW806772 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CALR    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
    SP1:                                                                                    
    SP2:                          -                                                         
    SP3:                                                                                    
    SP4:                                                                                    


    ECgene alternative splicing isoforms for CALR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CALR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCATCTTCAA
    CALR Expression
    About this image


    CALR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Double Negative 2 Thymocytes Thymus
             Bone marrow-derived hematopoietic stem cells (family)
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
    CALR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CALR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515162
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CALR (see all 7): 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Cellular Senescence in human mouse rat
              Cellular Stress Responses in human mouse rat
              Unfolded Protein Response in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CALR gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Calr1 , 5 calreticulin1, 5 88.21(n)1
    95.65(a)1
      8 (41.21 cM)5
    123171  NM_007591.31  NP_031617.11 
     848418505 
    chicken
    (Gallus gallus)
    Aves CALR31 calreticulin 3 66.38(n)
    65.41(a)
      420146  XM_418262.4  XP_418262.3 
    lizard
    (Anolis carolinensis)
    Reptilia CALR6
    calreticulin
    80(a)
    1 ↔ 1
    2(77770708-77779899)
    African clawed frog
    (Xenopus laevis)
    Amphibia calr-prov2 calreticulin 76.16(n)    BC046699.1 
    zebrafish
    (Danio rerio)
    Actinopterygii calr2 calreticulin 77.59(n)   30248  BC058314.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Crc1 , 3 central nervous system development
    calcium ion more3
    Calreticulin1
    70(a)3
    69.9(n)1
    72.35(a)1
      3 85E13
    411661  NM_001275501.11  NP_001262430.11 
    worm
    (Caenorhabditis elegans)
    Secernentea crt-11 , 3 calreticulin precursor3
    crt-11
    66(a)3
    67.35(n)1
    67.06(a)1
      V(6101766-6103103)3
    1789971  NM_072174.31  NP_504575.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CNE16
    Calnexin; integral membrane ER chaperone involved ...
    22(a)
    1 → many
    I(37464-38972) YAL058W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CRT1b1 CRT1b 59.61(n)
    57.06(a)
      837441  NM_100791.3  NP_172392.1 
    rice
    (Oryza sativa)
    Liliopsida Os.71582 Oryza sativa mRNA for calcium-binding protein, complete more 77.05(n)    AK099348.1 


    ENSEMBL Gene Tree for CALR (if available)
    TreeFam Gene Tree for CALR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CALR gene
    CLGN2  CALR32  CANX2  
    2 SIMAP similar genes for CALR using alignment to 4 protein entries:     CALR_HUMAN (see all proteins):
    CALR3    CLGN

    Find genes that share paralogs with CALR           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CALR
    PGOHUM00000244024


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CALR (see all 276)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1409587461,2
    C--12984366(+) CAGGCA/GTGAGC 1 -- us2k10--------
    rs741816821,2
    C--12984394(+) TTTTAG/TTTAAT 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs735053591,2
    C,F--12984536(+) GGAAGC/TGCCAA 1 -- us2k13Minor allele frequency- T:0.26WA CSA 122
    rs735053601,2
    C,F--12984587(+) CAAGAG/TGCCTG 1 -- us2k13Minor allele frequency- T:0.25WA CSA 122
    rs1823416401,2
    --12984802(+) CGATTC/TTCCCA 1 -- us2k10--------
    rs1122826501,2
    C,F--12984822(+) CCCGAG/ATACTG 1 -- us2k13Minor allele frequency- A:0.26WA CSA 122
    rs739252371,2
    C,F--12985160(+) ATCCCC/TCTCAT 1 -- us2k13Minor allele frequency- T:0.11WA CSA 122
    rs735053631,2
    C,F--12985304(+) GCTTCT/AGAAGA 1 -- us2k13Minor allele frequency- A:0.28WA CSA 122
    rs10102221,2
    C,F,O,A,H--12985555(+) TCCAGG/AAGTCA 1 -- us2k134Minor allele frequency- A:0.21NA NS EA MN WA CSA 4131
    rs1389578941,2
    --12985676(+) GGAACA/GTCTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CALR (13049392 - 13055304 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CALR:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911082CNV Loss21882294
    nsv911085CNV Loss21882294
    nsv833754CNV Loss17160897

    Human Gene Mutation Database (HGMD): CALR
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CALR
    DNA2.0 Custom Variant and Variant Library Synthesis for CALR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 109091   
    OMIM disorders: 254450  187950  
    16 diseases for CALR:    
    About MalaCards
    thrombocythemia, somatic    breast mucinous carcinoma    congenital heart block    myelofibrosis, somatic
    myelofibrosis with myeloid metaplasia, somatic    thrombocythemia 1    rubella    granulomatosis with polyangiitis
    onchocerciasis    catecholaminergic polymorphic ventricular tachycardia    malignant hyperthermia    dedifferentiated liposarcoma
    chagas disease    lupus erythematosus    pre-eclampsia    systemic lupus erythematosus

    3 diseases from the University of Copenhagen DISEASES database for CALR:
    Cancer     Onchocerciasis     Lupus erythematosus

    Find genes that share disorders with CALR           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CALR gene (see all 60)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis halothane 55.7 2 11141678 (1), 8415876 (1)
    congenital heart block 52.8 3 8904349 (1), 12601845 (1), 19886247 (1)
    autoimmune response 46.9 3 9796851 (1), 1602002 (1), 10320638 (1)
    shock 45 47 15383281 (3), 8676889 (3), 11328587 (2), 11290339 (2) (see all 38)
    sjogrens syndrome primary 44.4 3 8635291 (1), 2365822 (1)
    onchocerciasis 43.5 9 1602002 (4), 7520419 (2), 7680295 (1), 7836063 (1) (see all 5)
    lupus erythematosus systemic 41.3 13 8050453 (2), 9302659 (2), 16081363 (1), 16645988 (1) (see all 10)
    sjogrens syndrome 40.1 3 8478019 (1), 11480586 (1), 12410797 (1)
    complete heart block 33.1 1 16546685 (1)
    lupus erythematosus 32.7 2 8676889 (1), 2365822 (1)

    Genetic Association Database (GAD): CALR
    Human Genome Epidemiology (HuGE) Navigator: CALR (3 documents)

    Export disorders for CALR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CALR gene, integrated from 10 sources (see all 743):
    (articles sorted by number of sources associating them with CALR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human Ro/SS-A autoantigen is the homologue of calreticulin and is highly homologous with onchocercal RAL-1 antigen and an aplysia &quot;memory molecule&quot;. (PubMed id 2365822)1, 3, 9 McCauliffe D.P....Capra J.D. (J. Clin. Invest. 1990)
    2. Calreticulin is expressed on the cell surface of activated human peripheral blood T lymphocytes in association with major histocompatibility complex class I molecules. (PubMed id 10358038)1, 2, 9 Arosa F.A.... de Sousa M. (J. Biol. Chem. 1999)
    3. Calnexin and calreticulin bind to enzymically active tissue-type plasminogen activator during biosynthesis and are not required for folding to the native conformation. (PubMed id 9359841)1, 7, 9 Allen S. and Bulleid N.J. (Biochem. J. 1997)
    4. The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes. (PubMed id 8418194)1, 2, 9 Dupuis M.... Tschopp J. (J. Exp. Med. 1993)
    5. Calreticulin binds hYRNA and the 52-kDa polypeptide component of the Ro/SS-A ribonucleoprotein autoantigen. (PubMed id 8666824)1, 2, 9 Cheng S.T.... Sontheimer R.D. (J. Immunol. 1996)
    6. Human placental calreticulin: purification, characterization and association with other proteins. (PubMed id 7841019)1, 2, 9 Houen G. and Koch C. (Acta Chem. Scand. 1994)
    7. The 5'-flanking region of the human calreticulin gene shares homology with the human GRP78, GRP94, and protein disulfide isomerase promoters. (PubMed id 1733953)1, 2, 9 McCauliffe D.P.... Capra J.D. (J. Biol. Chem. 1992)
    8. Characterization of the autoantigen calreticulin. (PubMed id 1919005)1, 2, 9 Rokeach L.A.... Hoch S.O. (J. Immunol. 1991)
    9. X-ray structure of the human calreticulin globular domain reveals a peptide-binding area and suggests a multi-molecular mechanism. (PubMed id 21423620)1, 2 Chouquet A.... Gaboriaud C. (PLoS ONE 2011)
    10. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 811 HGNC: 1455 AceView: CALR Ensembl:ENSG00000179218 euGenes: HUgn811
    ECgene: CALR Kegg: 811 H-InvDB: CALR

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CALR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CALR Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Calreticulin
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_other_405

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CALR gene:
    Search GeneIP for patents involving CALR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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