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Aliases for CALR Gene

Aliases for CALR Gene

  • Calreticulin 2 3 5
  • Sicca Syndrome Antigen A (Autoantigen Ro; Calreticulin) 2 3
  • Endoplasmic Reticulum Resident Protein 60 3 4
  • Calregulin 3 4
  • CRP55 3 4
  • ERp60 3 4
  • HACBP 3 4
  • Grp60 3 4
  • Epididymis Secretory Sperm Binding Protein Li 99n 3
  • Autoantigen Ro 2
  • HEL-S-99n 3
  • CC1qR 3
  • CRTC 4
  • CRT 3
  • SSA 3
  • RO 3

External Ids for CALR Gene

Previous GeneCards Identifiers for CALR Gene

  • GC19P013180
  • GC19P013272
  • GC19P012894
  • GC19P012910
  • GC19P013049
  • GC19P012621

Summaries for CALR Gene

Entrez Gene Summary for CALR Gene

  • Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes. [provided by RefSeq, Jul 2008]

GeneCards Summary for CALR Gene

CALR (Calreticulin) is a Protein Coding gene. Diseases associated with CALR include thrombocythemia 1 and myelofibrosis with myeloid metaplasia, somatic. Among its related pathways are Transport to the Golgi and subsequent modification and Immune System. GO annotations related to this gene include poly(A) RNA binding and ubiquitin protein ligase binding. An important paralog of this gene is CANX.

UniProtKB/Swiss-Prot for CALR Gene

  • Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).

Gene Wiki entry for CALR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALR Gene

Genomics for CALR Gene

Regulatory Elements for CALR Gene

Promoters for CALR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CALR on UCSC Golden Path with GeneCards custom track

Genomic Location for CALR Gene

Chromosome:
19
Start:
12,938,578 bp from pter
End:
12,944,490 bp from pter
Size:
5,913 bases
Orientation:
Plus strand

Genomic View for CALR Gene

Genes around CALR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALR Gene

Proteins for CALR Gene

  • Protein details for CALR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27797-CALR_HUMAN
    Recommended name:
    Calreticulin
    Protein Accession:
    P27797
    Secondary Accessions:
    • Q6IAT4
    • Q9UDG2

    Protein attributes for CALR Gene

    Size:
    417 amino acids
    Molecular mass:
    48142 Da
    Quaternary structure:
    • Monomer. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interacts with PDIA3/ERp57 and C9orf9 (By similarity). Interacts with NR3C1 and TRIM21. Interacts with GABARAP. Interacts with PPIB.

    Three dimensional structures from OCA and Proteopedia for CALR Gene

neXtProt entry for CALR Gene

Proteomics data for CALR Gene at MOPED

Post-translational modifications for CALR Gene

  • Ubiquitination at Lys 24, Lys 48, Lys 55, and Lys 159
  • Glycosylation at Asn 344
  • Modification sites at PhosphoSitePlus

Other Protein References for CALR Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CALR (Calreticulin)

No data available for DME Specific Peptides for CALR Gene

Domains & Families for CALR Gene

Protein Domains for CALR Gene

Suggested Antigen Peptide Sequences for CALR Gene

Graphical View of Domain Structure for InterPro Entry

P27797

UniProtKB/Swiss-Prot:

CALR_HUMAN :
  • Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity.
  • Belongs to the calreticulin family.
Domain:
  • Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity.
  • The interaction with glycans occurs through a binding site in the globular lectin domain.
  • The zinc binding sites are localized to the N-domain.
  • Associates with PDIA3 through the tip of the extended arm formed by the P-domain.
Family:
  • Belongs to the calreticulin family.
genes like me logo Genes that share domains with CALR: view

No data available for Gene Families for CALR Gene

Function for CALR Gene

Molecular function for CALR Gene

GENATLAS Biochemistry:
calreticulin,calcium binding protein of endoplasmic and sarcoplasmic reticulum,48kDa
UniProtKB/Swiss-Prot Function:
Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).

Gene Ontology (GO) - Molecular Function for CALR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 11149926
GO:0005506 iron ion binding IEA --
GO:0031625 ubiquitin protein ligase binding IPI 8666824
GO:0050681 androgen receptor binding IDA 8107809
genes like me logo Genes that share ontologies with CALR: view
genes like me logo Genes that share phenotypes with CALR: view

Human Phenotype Ontology for CALR Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CALR Gene

MGI Knock Outs for CALR:

Animal Model Products

miRNA for CALR Gene

miRTarBase miRNAs that target CALR

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CALR Gene

Localization for CALR Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALR Gene

Endoplasmic reticulum lumen. Cytoplasm, cytosol. Secreted, extracellular space, extracellular matrix. Cell surface. Sarcoplasmic reticulum lumen. Note=Also found in cell surface (T cells), cytosol and extracellular matrix (PubMed:10358038). Associated with the lytic granules in the cytolytic T-lymphocytes. {ECO:0000269 PubMed:10358038, ECO:0000269 PubMed:8418194}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CALR Gene COMPARTMENTS Subcellular localization image for CALR gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
extracellular 5
nucleus 5
golgi apparatus 3
plasma membrane 3
cytoskeleton 2
mitochondrion 2
vacuole 2
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CALR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005737 cytoplasm IEA,IDA 1911778
GO:0005783 endoplasmic reticulum IEA,TAS 16130169
genes like me logo Genes that share ontologies with CALR: view

Pathways & Interactions for CALR Gene

genes like me logo Genes that share pathways with CALR: view

Gene Ontology (GO) - Biological Process for CALR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 8107809
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006355 regulation of transcription, DNA-templated TAS 8107808
GO:0006611 protein export from nucleus IDA 11149926
GO:0006874 cellular calcium ion homeostasis TAS 11149926
genes like me logo Genes that share ontologies with CALR: view

No data available for SIGNOR curated interactions for CALR Gene

Drugs & Compounds for CALR Gene

(35) Drugs for CALR Gene - From: Novoseek, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Melatonin Approved Nutra Antagonist, Target Melatonin receptors MT inhibitor 234
Antihemophilic Factor Approved, Investigational Pharma Target, chaperone 0
Tenecteplase Approved Pharma Target 39
calcium Nutra 0

(45) Additional Compounds for CALR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CALR: view

Transcripts for CALR Gene

Unigene Clusters for CALR Gene

Calreticulin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CALR Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1:
SP2: -
SP3:
SP4:

Relevant External Links for CALR Gene

GeneLoc Exon Structure for
CALR
ECgene alternative splicing isoforms for
CALR

Expression for CALR Gene

mRNA expression in normal human tissues for CALR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CALR Gene



SOURCE GeneReport for Unigene cluster for CALR Gene Hs.515162

genes like me logo Genes that share expression patterns with CALR: view

Protein tissue co-expression partners for CALR Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CALR Gene

Orthologs for CALR Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CALR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CALR 35
  • 89.56 (n)
  • 94.83 (a)
CALR 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CALR 35
  • 90.61 (n)
  • 96.55 (a)
CALR 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Calr 35
  • 88.21 (n)
  • 95.65 (a)
Calr 16
Calr 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CALR 35
  • 99.9 (n)
  • 100 (a)
CALR 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Calr 35
  • 87.73 (n)
  • 95.65 (a)
oppossum
(Monodelphis domestica)
Mammalia CALR 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CALR 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves CALR3 35
  • 66.38 (n)
  • 65.41 (a)
CALR 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CALR 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia calr 35
  • 76.55 (n)
  • 83.14 (a)
Str.538 35
African clawed frog
(Xenopus laevis)
Amphibia calr-prov 35
zebrafish
(Danio rerio)
Actinopterygii calr 35
calrl2 35
  • 73.72 (n)
  • 80 (a)
calrl2 36
  • 73 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9141 35
fruit fly
(Drosophila melanogaster)
Insecta Crc 37
  • 70 (a)
Crc 35
  • 69.9 (n)
  • 72.35 (a)
Crc 36
  • 67 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004212 35
  • 69.31 (n)
  • 71.47 (a)
worm
(Caenorhabditis elegans)
Secernentea crt-1 37
  • 66 (a)
crt-1 35
  • 67.35 (n)
  • 67.06 (a)
crt-1 36
  • 64 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CNE1 36
  • 22 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CRT1b 35
  • 59.61 (n)
  • 57.06 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1564 35
barley
(Hordeum vulgare)
Liliopsida Hv.1770 35
rice
(Oryza sativa)
Liliopsida Os.7158 35
Os07g0246200 35
  • 62.81 (n)
  • 59.05 (a)
corn
(Zea mays)
Liliopsida Zm.1288 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3623 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10660 36
  • 68 (a)
OneToMany
Species with no ortholog for CALR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CALR Gene

ENSEMBL:
Gene Tree for CALR (if available)
TreeFam:
Gene Tree for CALR (if available)

Paralogs for CALR Gene

Paralogs for CALR Gene

(2) SIMAP similar genes for CALR Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for CALR Gene

genes like me logo Genes that share paralogs with CALR: view

Variants for CALR Gene

Sequence variations from dbSNP and Humsavar for CALR Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1882693 -- 12,938,459(+) GCGCA(G/T)CCTAA upstream-variant-2KB
rs1010222 -- 12,937,794(+) TCCAG(A/G)AGTCA upstream-variant-2KB
rs2965220 -- 12,942,311(-) ATCTC(A/G)GCTCA intron-variant
rs2974751 -- 12,942,220(+) TTGCC(A/C)GGTGT intron-variant
rs12232837 -- 12,942,126(+) aggcc(A/G)aggcg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CALR Gene

Variant ID Type Subtype PubMed ID
nsv911082 CNV Loss 21882294
nsv833754 CNV Loss 17160897
nsv911085 CNV Loss 21882294

Variation tolerance for CALR Gene

Residual Variation Intolerance Score: 43.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CALR Gene

HapMap Linkage Disequilibrium report
CALR
Human Gene Mutation Database (HGMD)
CALR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALR Gene

Disorders for CALR Gene

MalaCards: The human disease database

(25) MalaCards diseases for CALR Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
thrombocythemia 1
  • thrombocythemia, somatic
myelofibrosis with myeloid metaplasia, somatic
  • myelofibrosis, somatic
essential thrombocythemia
  • hemorrhagic thrombocythemia
myelofibrosis
  • agnogenic myeloid metaplasia
calr-related essential thrombocythemia
  • thrombocythemia, somatic
- elite association - COSMIC cancer census association via MalaCards
Search CALR in MalaCards View complete list of genes associated with diseases

Relevant External Links for CALR

Genetic Association Database (GAD)
CALR
Human Genome Epidemiology (HuGE) Navigator
CALR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CALR
genes like me logo Genes that share disorders with CALR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CALR Gene

Publications for CALR Gene

  1. A human Ro/SS-A autoantigen is the homologue of calreticulin and is highly homologous with onchocercal RAL-1 antigen and an aplysia "memory molecule". (PMID: 2365822) McCauliffe D.P. … Capra J.D. (J. Clin. Invest. 1990) 2 3 23 67
  2. Melatonin: signaling mechanisms of a pleiotropic agent. (PMID: 19449447) Hardeland R. (Biofactors 2009) 23 25 26
  3. Calnexin and calreticulin bind to enzymically active tissue-type plasminogen activator during biosynthesis and are not required for folding to the native conformation. (PMID: 9359841) Allen S. … Bulleid N.J. (Biochem. J. 1997) 3 23 25
  4. Expression of calreticulin is associated with infiltration of T-cells in stage IIIB colon cancer. (PMID: 20480531) Peng R.Q. … Zhang X.S. (World J. Gastroenterol. 2010) 3 23
  5. Suppressive roles of calreticulin in prostate cancer growth and metastasis. (PMID: 19608864) Alur M. … Wang Z. (Am. J. Pathol. 2009) 3 23

Products for CALR Gene

Sources for CALR Gene

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