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Aliases for CALR Gene

Aliases for CALR Gene

  • Calreticulin 2 3
  • Sicca Syndrome Antigen A (Autoantigen Ro; Calreticulin) 2 3
  • Endoplasmic Reticulum Resident Protein 60 3 4
  • Calregulin 3 4
  • ERp60 3 4
  • CRP55 3 4
  • HACBP 3 4
  • Grp60 3 4
  • Epididymis Secretory Sperm Binding Protein Li 99n 3
  • Autoantigen Ro 2
  • Calreticulin) 6
  • HEL-S-99n 3
  • CC1qR 3
  • CRTC 4
  • SSA 3
  • CRT 3
  • RO 3

External Ids for CALR Gene

Summaries for CALR Gene

Entrez Gene Summary for CALR Gene

  • Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes. [provided by RefSeq, Jul 2008]

GeneCards Summary for CALR Gene

CALR (Calreticulin) is a Protein Coding gene. Diseases associated with CALR include breast mucinous carcinoma and congenital heart block. Among its related pathways are Disease and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include calcium ion binding and iron ion binding. An important paralog of this gene is CANX.

UniProtKB/Swiss-Prot for CALR Gene

  • Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).

Gene Wiki entry for CALR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALR Gene

Genomics for CALR Gene

Genomic Location for CALR Gene

Start:
12,938,578 bp from pter
End:
12,944,490 bp from pter
Size:
5,913 bases
Orientation:
Plus strand

Genomic View for CALR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CALR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALR Gene

Regulatory Elements for CALR Gene

Proteins for CALR Gene

  • Protein details for CALR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27797-CALR_HUMAN
    Recommended name:
    Calreticulin
    Protein Accession:
    P27797
    Secondary Accessions:
    • Q6IAT4
    • Q9UDG2

    Protein attributes for CALR Gene

    Size:
    417 amino acids
    Molecular mass:
    48142 Da
    Quaternary structure:
    • Monomer. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interacts with PDIA3/ERp57 and C9orf9 (By similarity). Interacts with NR3C1 and TRIM21. Interacts with GABARAP. Interacts with PPIB.

    Three dimensional structures from OCA and Proteopedia for CALR Gene

neXtProt entry for CALR Gene

Proteomics data for CALR Gene at MOPED

Post-translational modifications for CALR Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys24, Lys48, Lys55, and Lys159
  • Glycosylation at Asn344

Other Protein References for CALR Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CALR Gene

Domains for CALR Gene

Protein Domains for CALR Gene

UniProtKB/Swiss-Prot:

CALR_HUMAN
Domain:
  • Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity:
    • P27797
  • The interaction with glycans occurs through a binding site in the globular lectin domain:
    • P27797
  • The zinc binding sites are localized to the N-domain:
    • P27797
  • Associates with PDIA3 through the tip of the extended arm formed by the P-domain:
    • P27797
Family:
  • Belongs to the calreticulin family.:
    • P27797
genes like me logo Genes that share domains with CALR: view

No data available for Gene Families for CALR Gene

Function for CALR Gene

Molecular function for CALR Gene

GENATLAS Biochemistry: calreticulin,calcium binding protein of endoplasmic and sarcoplasmic reticulum,48kDa
UniProtKB/Swiss-Prot Function: Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).

Gene Ontology (GO) - Molecular Function for CALR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001849 complement component C1q binding TAS 15474971
GO:0001948 glycoprotein binding IPI 15056662
GO:0003677 DNA binding NAS 11149926
GO:0003729 mRNA binding IDA 14726956
GO:0005178 integrin binding IPI 1911778
genes like me logo Genes that share ontologies with CALR: view
genes like me logo Genes that share phenotypes with CALR: view

Animal Models for CALR Gene

MGI Knock Outs for CALR:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CALR Gene

Localization for CALR Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALR Gene

Endoplasmic reticulum lumen. Cytoplasm, cytosol. Secreted, extracellular space, extracellular matrix. Cell surface. Sarcoplasmic reticulum lumen. Note=Also found in cell surface (T cells), cytosol and extracellular matrix. Associated with the lytic granules in the cytolytic T-lymphocytes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CALR Gene COMPARTMENTS Subcellular localization image for CALR gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
extracellular 5
nucleus 4
cytoskeleton 2
golgi apparatus 2
mitochondrion 2
plasma membrane 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CALR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IDA 16502470
GO:0005622 intracellular TAS 7841019
genes like me logo Genes that share ontologies with CALR: view

Pathways for CALR Gene

genes like me logo Genes that share pathways with CALR: view

Gene Ontology (GO) - Biological Process for CALR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 8107809
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0002502 peptide antigen assembly with MHC class I protein complex ISS 11825569
GO:0006355 regulation of transcription, DNA-templated TAS 8107808
genes like me logo Genes that share ontologies with CALR: view

Compounds for CALR Gene

(1) HMDB Compounds for CALR Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(3) Drugbank Compounds for CALR Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Antihemophilic Factor
  • AHF
target chaperone
Melatonin
  • MEL
73-31-4 target
Tenecteplase
  • t- PA
191588-94-0 target

(77) Novoseek inferred chemical compound relationships for CALR Gene

Compound -log(P) Hits PubMed IDs
castanospermine 80.1 4
dolichyl diphosphate 76.4 1
kifunensine 60 1
tunicamycin 58.4 5
calcium 55 152
genes like me logo Genes that share compounds with CALR: view

Transcripts for CALR Gene

Unigene Clusters for CALR Gene

Calreticulin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CALR Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1:
SP2: -
SP3:
SP4:

Relevant External Links for CALR Gene

GeneLoc Exon Structure for
CALR
ECgene alternative splicing isoforms for
CALR

Expression for CALR Gene

mRNA expression in normal human tissues for CALR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CALR Gene

SOURCE GeneReport for Unigene cluster for CALR Gene Hs.515162

genes like me logo Genes that share expressions with CALR: view

Orthologs for CALR Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CALR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CALR 36
  • 99.9 (n)
  • 100 (a)
CALR 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CALR 36
  • 89.56 (n)
  • 94.83 (a)
CALR 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CALR 36
  • 90.61 (n)
  • 96.55 (a)
CALR 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Calr 36
  • 88.21 (n)
  • 95.65 (a)
Calr 16
Calr 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CALR 37
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CALR 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Calr 36
  • 87.73 (n)
  • 95.65 (a)
chicken
(Gallus gallus)
Aves CALR 37
  • 88 (a)
OneToOne
CALR3 36
  • 66.38 (n)
  • 65.41 (a)
lizard
(Anolis carolinensis)
Reptilia CALR 37
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia calr-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia calr 36
  • 76.55 (n)
  • 83.14 (a)
Str.538 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9141 36
zebrafish
(Danio rerio)
Actinopterygii calr 36
calrl2 36
  • 73.72 (n)
  • 80 (a)
calrl2 37
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004212 36
  • 69.31 (n)
  • 71.47 (a)
fruit fly
(Drosophila melanogaster)
Insecta Crc 36
  • 69.9 (n)
  • 72.35 (a)
Crc 37
  • 67 (a)
OneToMany
Crc 38
  • 70 (a)
worm
(Caenorhabditis elegans)
Secernentea crt-1 36
  • 67.35 (n)
  • 67.06 (a)
crt-1 37
  • 64 (a)
OneToMany
crt-1 38
  • 66 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CNE1 37
  • 22 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1564 36
thale cress
(Arabidopsis thaliana)
eudicotyledons CRT1b 36
  • 59.61 (n)
  • 57.06 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.1770 36
corn
(Zea mays)
Liliopsida Zm.1288 36
rice
(Oryza sativa)
Liliopsida Os.7158 36
Os07g0246200 36
  • 62.81 (n)
  • 59.05 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3623 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10660 37
  • 68 (a)
OneToMany
Species with no ortholog for CALR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CALR Gene

ENSEMBL:
Gene Tree for CALR (if available)
TreeFam:
Gene Tree for CALR (if available)

Paralogs for CALR Gene

Paralogs for CALR Gene

Selected SIMAP similar genes for CALR Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for CALR Gene

genes like me logo Genes that share paralogs with CALR: view

Variants for CALR Gene

Sequence variations from dbSNP and Humsavar for CALR Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1010222 -- 12,937,794(+) TCCAG(A/G)AGTCA upstream-variant-2KB
rs1882693 -- 12,938,459(+) GCGCA(G/T)CCTAA upstream-variant-2KB
rs2965220 -- 12,942,311(-) ATCTC(A/G)GCTCA intron-variant
rs2974751 -- 12,942,220(+) TTGCC(A/C)GGTGT intron-variant
rs11878305 -- 12,938,466(+) CTAAC(A/C/G/T)TAGTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CALR Gene

Variant ID Type Subtype PubMed ID
nsv911082 CNV Loss 21882294
nsv833754 CNV Loss 17160897
nsv911085 CNV Loss 21882294

Relevant External Links for CALR Gene

HapMap Linkage Disequilibrium report
CALR
Human Gene Mutation Database (HGMD)
CALR

Disorders for CALR Gene

(2) OMIM Diseases for CALR Gene (109091)

(3) University of Copenhagen DISEASES for CALR Gene

(60) Novoseek inferred disease relationships for CALR Gene

Disease -log(P) Hits PubMed IDs
hepatitis halothane 55.7 2
congenital heart block 52.8 3
autoimmune response 46.9 3
shock 45 44
sjogrens syndrome primary 44.4 2

Relevant External Links for CALR

Genetic Association Database (GAD)
CALR
Human Genome Epidemiology (HuGE) Navigator
CALR
genes like me logo Genes that share disorders with CALR: view

No data available for UniProtKB/Swiss-Prot for CALR Gene

Publications for CALR Gene

  1. The 5'-flanking region of the human calreticulin gene shares homology with the human GRP78, GRP94, and protein disulfide isomerase promoters. (PMID: 1733953) McCauliffe D.P. … Capra J.D. (J. Biol. Chem. 1992) 3 4 23
  2. Characterization of the autoantigen calreticulin. (PMID: 1919005) Rokeach L.A. … Hoch S.O. (J. Immunol. 1991) 3 4 23
  3. Human placental calreticulin: purification, characterization and association with other proteins. (PMID: 7841019) Houen G. … Koch C. (Acta Chem. Scand. 1994) 3 4 23
  4. A human Ro/SS-A autoantigen is the homologue of calreticulin and is highly homologous with onchocercal RAL-1 antigen and an aplysia "memory molecule". (PMID: 2365822) McCauliffe D.P. … Capra J.D. (J. Clin. Invest. 1990) 2 3 23
  5. The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes. (PMID: 8418194) Dupuis M. … Tschopp J. (J. Exp. Med. 1993) 3 4 23

Products for CALR Gene

Sources for CALR Gene

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