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Aliases for CALML6 Gene

Aliases for CALML6 Gene

  • Calmodulin Like 6 2 3 5
  • Calglandulin-Like Protein 3 4
  • Calmodulin-Like 6 2 3
  • CAGLP 3 4
  • EF-Hand Protein 3
  • CALGP 4

External Ids for CALML6 Gene

Previous GeneCards Identifiers for CALML6 Gene

  • GC01P001880
  • GC01P001126

Summaries for CALML6 Gene

GeneCards Summary for CALML6 Gene

CALML6 (Calmodulin Like 6) is a Protein Coding gene. Among its related pathways are cAMP signaling pathway and Ras signaling pathway. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CABP2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALML6 Gene

Genomics for CALML6 Gene

Regulatory Elements for CALML6 Gene

Genomic Location for CALML6 Gene

Chromosome:
1
Start:
1,913,752 bp from pter
End:
1,917,296 bp from pter
Size:
3,545 bases
Orientation:
Plus strand

Genomic View for CALML6 Gene

Genes around CALML6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALML6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALML6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALML6 Gene

Proteins for CALML6 Gene

  • Protein details for CALML6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD86-CALL6_HUMAN
    Recommended name:
    Calmodulin-like protein 6
    Protein Accession:
    Q8TD86
    Secondary Accessions:
    • A2A2M3
    • Q6Q2C4

    Protein attributes for CALML6 Gene

    Size:
    181 amino acids
    Molecular mass:
    20690 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CALML6 Gene

Proteomics data for CALML6 Gene at MOPED

Post-translational modifications for CALML6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CALML6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CALML6 Gene

Domains & Families for CALML6 Gene

Gene Families for CALML6 Gene

Protein Domains for CALML6 Gene

Suggested Antigen Peptide Sequences for CALML6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TD86

UniProtKB/Swiss-Prot:

CALL6_HUMAN :
  • Contains 4 EF-hand domains.
  • Belongs to the calmodulin family. Calglandulin subfamily.
Domain:
  • Contains 4 EF-hand domains.
Family:
  • Belongs to the calmodulin family. Calglandulin subfamily.
genes like me logo Genes that share domains with CALML6: view

Function for CALML6 Gene

Phenotypes for CALML6 Gene

GenomeRNAi human phenotypes for CALML6:
genes like me logo Genes that share phenotypes with CALML6: view

Animal Model Products

CRISPR Products

miRNA for CALML6 Gene

miRTarBase miRNAs that target CALML6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CALML6 Gene

Localization for CALML6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALML6 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CALML6 Gene COMPARTMENTS Subcellular localization image for CALML6 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for CALML6 Gene

Pathways & Interactions for CALML6 Gene

genes like me logo Genes that share pathways with CALML6: view

Interacting Proteins for CALML6 Gene

Gene Ontology (GO) - Biological Process for CALML6 Gene

None

No data available for SIGNOR curated interactions for CALML6 Gene

Drugs & Compounds for CALML6 Gene

No Compound Related Data Available

Transcripts for CALML6 Gene

mRNA/cDNA for CALML6 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CALML6 Gene

Calmodulin-like 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CALML6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1:
SP2: -

Relevant External Links for CALML6 Gene

GeneLoc Exon Structure for
CALML6
ECgene alternative splicing isoforms for
CALML6

Expression for CALML6 Gene

mRNA expression in normal human tissues for CALML6 Gene

mRNA differential expression in normal tissues according to GTEx for CALML6 Gene

This gene is overexpressed in Muscle - Skeletal (x17.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CALML6 Gene



SOURCE GeneReport for Unigene cluster for CALML6 Gene Hs.85902

mRNA Expression by UniProt/SwissProt for CALML6 Gene

Q8TD86-CALL6_HUMAN
Tissue specificity: Expressed in prostate, thymus, heart, skeleton muscle, bone marrow and ovary.
genes like me logo Genes that share expression patterns with CALML6: view

Protein tissue co-expression partners for CALML6 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein differential expression in normal tissues for CALML6 Gene

Orthologs for CALML6 Gene

This gene was present in the common ancestor of animals.

Orthologs for CALML6 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CALML6 35
  • 85.27 (n)
  • 88.37 (a)
CALML6 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CALML6 35
  • 98.34 (n)
  • 98.34 (a)
CALML6 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CALML6 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CALML6 36
  • 53 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii calml4b 36
  • 28 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17770 36
  • 32 (a)
OneToMany
CG5024 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4307 36
  • 44 (a)
OneToOne
Species with no ortholog for CALML6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CALML6 Gene

ENSEMBL:
Gene Tree for CALML6 (if available)
TreeFam:
Gene Tree for CALML6 (if available)

Paralogs for CALML6 Gene

Paralogs for CALML6 Gene

(20) SIMAP similar genes for CALML6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CALML6: view

Variants for CALML6 Gene

Sequence variations from dbSNP and Humsavar for CALML6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs28581776 - 1,916,540(+) TGGAG(C/T)GGCTC reference, missense
rs2247560 -- 1,915,326(-) TGGTC(C/T)CATGC intron-variant, reference, missense
rs2474459 -- 1,913,643(-) TAGAC(A/G)CCTGT upstream-variant-2KB
rs2474460 -- 1,912,607(-) AAAAT(A/G)TTATT upstream-variant-2KB
rs2748986 -- 1,916,417(-) CCGGC(A/C)TGACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CALML6 Gene

Variant ID Type Subtype PubMed ID
dgv9e1 CNV Complex 17122850
nsv834335 CNV Loss 17160897
dgv55n71 CNV Loss 21882294
dgv56n71 CNV Loss 21882294
nsv871672 CNV Loss 21882294
nsv870914 CNV Loss 21882294
nsv10383 CNV Gain 18304495

Variation tolerance for CALML6 Gene

Residual Variation Intolerance Score: 78.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.24; 81.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CALML6 Gene

HapMap Linkage Disequilibrium report
CALML6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALML6 Gene

Disorders for CALML6 Gene

Relevant External Links for CALML6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CALML6

No disorders were found for CALML6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CALML6 Gene

Publications for CALML6 Gene

  1. Cloning and characterization of human CAGLP gene encoding a novel EF- hand protein. (PMID: 15621662) Chen S. … Yu L. (DNA Seq. 2004) 3 4 23 67
  2. Proteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine-activated conditions. (PMID: 19294699) Chiarini A. … Dal Pra I. (Proteomics 2009) 3
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CALML6 Gene

Sources for CALML6 Gene

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