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Aliases for CALML6 Gene

Aliases for CALML6 Gene

  • Calmodulin-Like 6 2 3
  • CAGLP 3 4 6
  • Calglandulin-Like Protein 3 4
  • Calmodulin-Like Protein 6 3
  • EF-Hand Protein 3
  • CALGP 4

External Ids for CALML6 Gene

Summaries for CALML6 Gene

GeneCards Summary for CALML6 Gene

CALML6 (Calmodulin-Like 6) is a Protein Coding gene. Diseases associated with CALML6 include pertussis. Among its related pathways are Ras signaling pathway and Ras signaling pathway. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CABP2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALML6 Gene

Genomics for CALML6 Gene

Genomic Location for CALML6 Gene

Start:
1,914,827 bp from pter
End:
1,917,296 bp from pter
Size:
2,470 bases
Orientation:
Plus strand

Genomic View for CALML6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CALML6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALML6 Gene

Regulatory Elements for CALML6 Gene

Proteins for CALML6 Gene

  • Protein details for CALML6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD86-CALL6_HUMAN
    Recommended name:
    Calmodulin-like protein 6
    Protein Accession:
    Q8TD86
    Secondary Accessions:
    • A2A2M3
    • Q6Q2C4

    Protein attributes for CALML6 Gene

    Size:
    181 amino acids
    Molecular mass:
    20690 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CALML6 Gene

Proteomics data for CALML6 Gene at MOPED

Post-translational modifications for CALML6 Gene

No Post-translational modifications

Other Protein References for CALML6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CALML6 Gene

Domains for CALML6 Gene

Gene Families for CALML6 Gene

HGNC:
  • EFHAND :EF-hand domain containing

Protein Domains for CALML6 Gene

UniProtKB/Swiss-Prot:

CALL6_HUMAN
Domain:
  • Contains 4 EF-hand domains.:
    • Q8TD86
Family:
  • Belongs to the calmodulin family. Calglandulin subfamily.:
    • Q8TD86
genes like me logo Genes that share domains with CALML6: view

Function for CALML6 Gene

Gene Ontology (GO) - Molecular Function for CALML6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with CALML6: view

miRNA for CALML6 Gene

miRTarBase miRNAs that target CALML6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CALML6 Gene

Localization for CALML6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALML6 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CALML6 Gene COMPARTMENTS Subcellular localization image for CALML6 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for CALML6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CALML6: view

Transcripts for CALML6 Gene

mRNA/cDNA for CALML6 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CALML6 Gene

Calmodulin-like 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CALML6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
SP1:
SP2: -

Relevant External Links for CALML6 Gene

GeneLoc Exon Structure for
CALML6
ECgene alternative splicing isoforms for
CALML6

Expression for CALML6 Gene

mRNA expression in normal human tissues for CALML6 Gene

mRNA differential expression in normal tissues according to GTEx for CALML6 Gene

This gene is overexpressed in Muscle - Skeletal (17.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CALML6 Gene

SOURCE GeneReport for Unigene cluster for CALML6 Gene Hs.85902

mRNA Expression by UniProt/SwissProt for CALML6 Gene

Q8TD86-CALL6_HUMAN
Tissue specificity: Expressed in prostate, thymus, heart, skeleton muscle, bone marrow and ovary.
genes like me logo Genes that share expressions with CALML6: view

Orthologs for CALML6 Gene

This gene was present in the common ancestor of animals.

Orthologs for CALML6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CALML6 36
  • 98.34 (n)
  • 98.34 (a)
CALML6 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CALML6 37
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CALML6 36
  • 85.27 (n)
  • 88.37 (a)
CALML6 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CALML6 37
  • 53 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii calml4b 37
  • 28 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17770 37
  • 32 (a)
OneToMany
CG5024 37
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4307 37
  • 44 (a)
OneToOne
Species with no ortholog for CALML6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CALML6 Gene

ENSEMBL:
Gene Tree for CALML6 (if available)
TreeFam:
Gene Tree for CALML6 (if available)

Paralogs for CALML6 Gene

Paralogs for CALML6 Gene

Selected SIMAP similar genes for CALML6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CALML6: view

Variants for CALML6 Gene

Sequence variations from dbSNP and Humsavar for CALML6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2247560 -- 1,915,326(-) TGGTC(C/T)CATGC intron-variant, upstream-variant-2KB
rs2474459 -- 1,913,643(-) TAGAC(A/G)CCTGT upstream-variant-2KB
rs2748986 -- 1,916,417(-) CCGGC(A/C)TGACC intron-variant
rs2748987 -- 1,915,143(-) GACCA(C/T)CTTGT utr-variant-5-prime, upstream-variant-2KB
rs2748988 -- 1,914,918(-) TGGTC(C/T)GTATC utr-variant-5-prime, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CALML6 Gene

Variant ID Type Subtype PubMed ID
dgv9e1 CNV Complex 17122850
nsv834335 CNV Loss 17160897
dgv55n71 CNV Loss 21882294
dgv56n71 CNV Loss 21882294
nsv871672 CNV Loss 21882294
nsv870914 CNV Loss 21882294
nsv10383 CNV Gain 18304495

Relevant External Links for CALML6 Gene

HapMap Linkage Disequilibrium report
CALML6

Disorders for CALML6 Gene

(1) MalaCards Diseases for CALML6 Gene

Search for CALML6 Gene in MalaCards »
genes like me logo Genes that share disorders with CALML6: view

No data available for UniProtKB/Swiss-Prot for CALML6 Gene

Publications for CALML6 Gene

  1. Cloning and characterization of human CAGLP gene encoding a novel EF- hand protein. (PMID: 15621662) Chen S. … Yu L. (DNA Seq. 2004) 3 4 23
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. Proteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine-activated conditions. (PMID: 19294699) Chiarini A. … Dal Pra I. (Proteomics 2009) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CALML6 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CALML6
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CALML6
    • Block miRNA regulation of CALML6 using miScript Target Protectors

    Sources for CALML6 Gene

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