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Aliases for CALML5 Gene

Aliases for CALML5 Gene

  • Calmodulin-Like 5 2 3
  • Calmodulin-Like Skin Protein 2 3 4
  • CLSP 3 4
  • Calmodulin-Like Protein 5 3

External Ids for CALML5 Gene

Summaries for CALML5 Gene

Entrez Gene Summary for CALML5 Gene

  • This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes. [provided by RefSeq, Jul 2008]

GeneCards Summary for CALML5 Gene

CALML5 (Calmodulin-Like 5) is a Protein Coding gene. Diseases associated with CALML5 include pertussis. Among its related pathways are Ras signaling pathway and Ras signaling pathway. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CABP2.

UniProtKB/Swiss-Prot for CALML5 Gene

  • Binds calcium. May be involved in terminal differentiation of keratinocytes

Gene Wiki entry for CALML5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALML5 Gene

Genomics for CALML5 Gene

Genomic Location for CALML5 Gene

5,498,695 bp from pter
5,499,570 bp from pter
876 bases
Minus strand

Genomic View for CALML5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CALML5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALML5 Gene

Regulatory Elements for CALML5 Gene

Proteins for CALML5 Gene

  • Protein details for CALML5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calmodulin-like protein 5
    Protein Accession:
    Secondary Accessions:
    • Q5SQI3
    • Q8IXU8

    Protein attributes for CALML5 Gene

    146 amino acids
    Molecular mass:
    15893 Da
    Quaternary structure:
    • Associates with transglutaminase 3

    Three dimensional structures from OCA and Proteopedia for CALML5 Gene

neXtProt entry for CALML5 Gene

Proteomics data for CALML5 Gene at MOPED

Post-translational modifications for CALML5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CALML5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CALML5 Gene

Domains for CALML5 Gene

Gene Families for CALML5 Gene

  • EFHAND :EF-hand domain containing

Protein Domains for CALML5 Gene


  • Contains 4 EF-hand domains.:
    • Q9NZT1
genes like me logo Genes that share domains with CALML5: view

Function for CALML5 Gene

Molecular function for CALML5 Gene

UniProtKB/Swiss-Prot Function: Binds calcium. May be involved in terminal differentiation of keratinocytes

Gene Ontology (GO) - Molecular Function for CALML5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with CALML5: view

Phenotypes for CALML5 Gene

GenomeRNAi human phenotypes for CALML5:
genes like me logo Genes that share phenotypes with CALML5: view

miRNA for CALML5 Gene

miRTarBase miRNAs that target CALML5

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CALML5 Gene

Localization for CALML5 Gene

Subcellular locations from

Jensen Localization Image for CALML5 Gene COMPARTMENTS Subcellular localization image for CALML5 gene
Compartment Confidence
cytosol 3
extracellular 2
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CALML5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CALML5: view

Pathways for CALML5 Gene

genes like me logo Genes that share pathways with CALML5: view

Pathways by source for CALML5 Gene

Gene Ontology (GO) - Biological Process for CALML5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10777582
GO:0008544 epidermis development TAS 10777582
genes like me logo Genes that share ontologies with CALML5: view

Compounds for CALML5 Gene

(1) HMDB Compounds for CALML5 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
genes like me logo Genes that share compounds with CALML5: view

Transcripts for CALML5 Gene

mRNA/cDNA for CALML5 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CALML5 Gene

Calmodulin-like 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CALML5 Gene

No ASD Table

Relevant External Links for CALML5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CALML5 Gene

mRNA expression in normal human tissues for CALML5 Gene

mRNA differential expression in normal tissues according to GTEx for CALML5 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (26.1) and Skin - Not Sun Exposed (Suprapubic) (20.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CALML5 Gene

SOURCE GeneReport for Unigene cluster for CALML5 Gene Hs.180142

mRNA Expression by UniProt/SwissProt for CALML5 Gene

Tissue specificity: Particularly abundant in the epidermis where its expression is directly related to keratinocyte differentiation. Very low expression in lung
genes like me logo Genes that share expressions with CALML5: view

Orthologs for CALML5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CALML5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CALML5 36
  • 98.17 (n)
  • 95.89 (a)
  • 96 (a)
(Bos Taurus)
Mammalia CALML5 36
  • 72.41 (n)
  • 57.93 (a)
  • 56 (a)
(Canis familiaris)
Mammalia CALML5 36
  • 76.48 (n)
  • 58.22 (a)
  • 57 (a)
(Mus musculus)
Mammalia Calm4 36
  • 63.85 (n)
  • 52.11 (a)
Calm4 16
(Monodelphis domestica)
Mammalia -- 37
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia CALML5 37
  • 44 (a)
(Rattus norvegicus)
Mammalia Calml5 36
  • 64.84 (n)
  • 52.05 (a)
(Danio rerio)
Actinopterygii tnnc1b 37
  • 29 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11165 37
  • 35 (a)
CG31958 37
  • 31 (a)
CG31960 37
  • 39 (a)
(Caenorhabditis elegans)
Secernentea cal-1 37
  • 36 (a)
cal-2 37
  • 36 (a)
cal-3 37
  • 24 (a)
cal-4 37
  • 25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMD1 37
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7047 37
  • 34 (a)
Species with no ortholog for CALML5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CALML5 Gene

Gene Tree for CALML5 (if available)
Gene Tree for CALML5 (if available)

Paralogs for CALML5 Gene

Paralogs for CALML5 Gene

Selected SIMAP similar genes for CALML5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CALML5: view

Variants for CALML5 Gene

Sequence variations from dbSNP and Humsavar for CALML5 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs4623783 -- 5,498,466(-) AGGAC(C/T)TGGGC downstream-variant-500B
rs4881465 -- 5,498,803(+) CAAGG(G/T)CTGGA utr-variant-3-prime
rs4881466 -- 5,500,146(+) TGCCT(A/G)TAACT upstream-variant-2KB
rs10904516 - 5,499,218(-) GGCGA(A/G)GAAGG reference, missense
rs10904517 -- 5,499,220(-) GCGGC(A/G)AAGAA synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for CALML5 Gene

Variant ID Type Subtype PubMed ID
nsv894783 CNV Loss 21882294
nsv831774 CNV Gain 17160897
dgv600n71 CNV Loss 21882294
nsv894798 CNV Loss 21882294

Relevant External Links for CALML5 Gene

HapMap Linkage Disequilibrium report

Disorders for CALML5 Gene

(1) MalaCards Diseases for CALML5 Gene

Search for CALML5 Gene in MalaCards »
genes like me logo Genes that share disorders with CALML5: view

No data available for UniProtKB/Swiss-Prot for CALML5 Gene

Publications for CALML5 Gene

  1. Identification and cloning of a new calmodulin-like protein from human epidermis. (PMID: 10777582) Mehul B. … Schmidt R. (J. Biol. Chem. 2000) 2 3 4 23
  2. A structural and dynamic characterization of the EF-hand protein CLSP. (PMID: 16765896) Babini E. … Luchinat C. (Structure 2006) 3 4 23
  3. Influence of calcium on the proteolytic degradation of the calmodulin-like skin protein (calmodulin-like protein 5) in psoriatic epidermis. (PMID: 16689864) MAchul B. … Schmidt R. (Exp. Dermatol. 2006) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Large-scale analysis of the human ubiquitin-related proteome. (PMID: 16196087) Matsumoto M. … Nakayama K.I. (Proteomics 2005) 3

Products for CALML5 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CALML5
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CALML5
    • Block miRNA regulation of CALML5 using miScript Target Protectors
    • antibodies-online proteins for CALML5
    • antibodies-online antibodies for CALML5
    • antibodies-online kits for CALML5

    Sources for CALML5 Gene

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