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CALML5 Gene

protein-coding   GIFtS: 54
GCID: GC10M005530

Calmodulin-Like 5

  See CALML5-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calmodulin-Like 51 2
Calmodulin-Like Skin Protein1 2 3
CLSP2 3
Calmodulin-Like Protein 52

External Ids:    HGNC: 181801   Entrez Gene: 518062   Ensembl: ENSG000001783727   OMIM: 6051835   UniProtKB: Q9NZT13   

Export aliases for CALML5 gene to outside databases

Previous GC identifer: GC10M005494


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CALML5 Gene:
This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family
of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and
undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed
epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase
3, shown to be a key enzyme in the terminal differentiation of keratinocytes. (provided by RefSeq, Jul 2008)

GeneCards Summary for CALML5 Gene:
CALML5 (calmodulin-like 5) is a protein-coding gene. Diseases associated with CALML5 include pertussis. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CALML3.

UniProtKB/Swiss-Prot: CALL5_HUMAN, Q9NZT1
Function: Binds calcium. May be involved in terminal differentiation of keratinocytes

Gene Wiki entry for CALML5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_008705.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CALML5 gene promoter:
         p53   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   STAT5A   CUTL1   POU3F2   LCR-F1   GATA-2   POU2F1a   HSF2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCALML5 promoter sequence
   Search Chromatin IP Primers for CALML5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CALML5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15.1   Ensembl cytogenetic band:  10p15.1   HGNC cytogenetic band: 10p15.1

CALML5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALML5 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M005530:  view genomic region     (about GC identifiers)

Start:
5,540,658 bp from pter      End:
5,541,533 bp from pter
Size:
876 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CALL5_HUMAN, Q9NZT1 (See protein sequence)
Recommended Name: Calmodulin-like protein 5  
Size: 146 amino acids; 15893 Da
Subunit: Associates with transglutaminase 3
1 PDB 3D structure from and Proteopedia for CALML5:
2B1U (3D)    
Secondary accessions: Q5SQI3 Q8IXU8

Explore the universe of human proteins at neXtProt for CALML5: NX_Q9NZT1

Explore proteomics data for CALML5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CALML5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_059118.2  
    ENSEMBL proteins: 
     ENSP00000369689  

    CALML5 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    3 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry Q9NZT1

    ProtoNet protein and cluster: Q9NZT1

    UniProtKB/Swiss-Prot: CALL5_HUMAN, Q9NZT1
    Similarity: Contains 4 EF-hand domains


    Find genes that share domains with CALML5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CALL5_HUMAN, Q9NZT1
    Function: Binds calcium. May be involved in terminal differentiation of keratinocytes

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
         
    Find genes that share ontologies with CALML5           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CALML5:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CALML5
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    miRTarBase miRNAs that target CALML5:
    hsa-mir-335-5p (MIRT018952), hsa-mir-9-5p (MIRT021412)

    Block miRNA regulation of human, mouse, rat CALML5 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CALML5
    SwitchGear 3'UTR luciferase reporter plasmidCALML5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CALML5

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    extracellular2
    nucleus2
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CALML5 About   (see all 21)  
    See pathways by source

    SuperPathContained pathways About
    1Alzheimer's disease
    Alzheimers Disease0.44
    Alzheimer's disease0.44
    2Development Endothelin 1 EDNRA signaling
    GnRH signaling pathway0.38
    Estrogen signaling pathway0.34
    Inflammatory mediator regulation of TRP channels0.37
    3Circadian entrainment
    Circadian entrainment0.40
    Dopaminergic synapse0.37
    4Ras signaling pathway
    Rap1 signaling pathway0.36
    Ras signaling pathway0.36
    5Salivary secretion
    Salivary secretion0.34
    Gastric acid secretion0.34


    Find genes that share SuperPaths with CALML5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CALML5
        Alzheimers Disease



    Selected Kegg Pathways  (Kegg details for CALML5) (see all 27):
        Ras signaling pathway
    Rap1 signaling pathway
    Calcium signaling pathway
    Phosphatidylinositol signaling system
    Oocyte meiosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CALML5
    Interactions:

        GeneGlobe Interaction Network for CALML5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CALML5 (Q9NZT13 ENSP000003696894) via UniProtKB, MINT, STRING, and/or I2D (see all 79)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAGED1Q9Y5V33, ENSP000003648474I2D: score=2 STRING: ENSP00000364847
    USP1O947823, ENSP000003435264I2D: score=2 STRING: ENSP00000343526
    SLX4Q8IY923, ENSP000002940084I2D: score=1 STRING: ENSP00000294008
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    TGM3Q081883, ENSP000003708674I2D: score=1 STRING: ENSP00000370867
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS10777582
    GO:0008544epidermis development TAS10777582

    Find genes that share ontologies with CALML5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CALML5 (CALL5)

    1 HMDB Compound for CALML5    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CALML5 gene: 
    NM_017422.4  

    Unigene Cluster for CALML5:

    Calmodulin-like 5
    Hs.180142  [show with all ESTs]
    Unigene Representative Sequence: BG676307
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000380332(uc001iic.2)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat CALML5
      QuantiFast Probe-based Assays in human, mouse, rat CALML5

    Additional mRNA sequence: 

    AF172852.1 AK222744.1 BC039172.1 

    1 DOTS entry:

    DT.106513 

    16 AceView cDNA sequences:

    AI791495 BG676307 NM_017422 BC039172 BG680086 BG743203 AI791325 AI791964 
    BG696865 BG697492 AI732539 AA601601 AI732667 AF172852 AA709067 AA505923 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CALML5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCCGCGAGG
    CALML5 Expression
    About this image

    CALML5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CALML5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.180142

    UniProtKB/Swiss-Prot: CALL5_HUMAN, Q9NZT1
    Tissue specificity: Particularly abundant in the epidermis where its expression is directly related to
    keratinocyte differentiation. Very low expression in lung

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CALML5 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Calm41 , 5 calmodulin 41, 5 63.85(n)1
    52.11(a)1
      13 (2.15 cM)5
    807961  NM_020036.41  NP_064420.21 
     38377575 
    zebrafish
    (Danio rerio)
    Actinopterygii tnnc1b6
    troponin C type 1b (slow)
    29(a)
    many ↔ many
    23(20398636-20401146) ENSDARG00000037539
    fruit fly
    (Drosophila melanogaster)
    Insecta CG319606
    CG111656
    (see all 3)
    --
    39(a)
    35(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    2L(3784947-3785622)
    2R(3837344-3837970)
    worm
    (Caenorhabditis elegans)
    Secernentea cal-26
    cal-16
    (see all 4)
    Protein CAL-1, isoform b
    (see all 4)
    36(a)
    36(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    II(8960712-8961570) WBGene00000286
    V(12514876-12517205) WBGene00000285
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CMD16
    Calmodulin; Ca++ binding protein that regulates Ca...
    37(a)
    1 → many
    II(457919-458362) YBR109C


    ENSEMBL Gene Tree for CALML5 (if available)
    TreeFam Gene Tree for CALML5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CALML5 gene
    CALML32  CABP52  CABP12  TNNC12  CALM32  CABP42  CABP22  CALM12  
    CALML62  TNNC22  CALML42  CALM22  
    Selected SIMAP similar genes for CALML5 using alignment to 1 protein entry:     CALL5_HUMAN(see all similar genes):
    CALM2    CALM1    CALM3    CALML3    CALN1    CETN2
    TNNC2    CETN1    TNNC1    CABP1    MYL1    CETN3
    CABP2    MYL6    CALML4    SLC25A24    CABP5    CALML6

    Find genes that share paralogs with CALML5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CALML5 (see all 88)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1881444441,2
    --5540172(+) TCAGAC/TACACA 1 -- ds50010--------
    rs1128311351,2
    C--5540210(+) GCACAC/GAAGGA 1 -- ds50012Minor allele frequency- G:0.03CSA WA 120
    rs1916404631,2
    C--5540234(+) AAACAA/TACAGA 1 -- ds50010--------
    rs1382282881,2
    --5540280(+) ATACAC/GACACA 1 -- ds50010--------
    rs1495553291,2
    C--5540310(+) ACACAA/CAGACG 1 -- ds50010--------
    rs46237831,2
    C--5540429(-) AGGACC/TTGGGC 1 -- ds50012Minor allele frequency- T:0.00NA 4
    rs741130801,2
    C,F--5540569(+) GTTCTG/CCCACC 1 -- ds50012Minor allele frequency- C:0.04WA 120
    rs1430889451,2
    --5540580(+) CAGGT-/GAGAGGG
    GTGGGCTGG
    GAGAG
    1 -- ds50010--------
    rs1835969051,2
    --5540602(+) AAGGAA/GCCCTG 1 -- ds50010--------
    rs1888858161,2
    --5540731(+) AAGGGA/GGACCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CALML5 (5540658 - 5541533 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CALML5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv894783CNV Loss21882294
    nsv894798CNV Loss21882294
    dgv600n71CNV Loss21882294
    nsv831774CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605183    OMIM disorders: --

    1 disease for CALML5:    
    About MalaCards
    pertussis


    Find genes that share disorders with CALML5           About GenesLikeMe


    Export disorders for CALML5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CALML5 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with CALML5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and cloning of a new calmodulin-like protein from human epidermis. (PubMed id 10777582)1, 2, 3, 9 Mehul B.... Schmidt R. (J. Biol. Chem. 2000)
    2. A structural and dynamic characterization of the EF-hand protein CLSP. (PubMed id 16765896)1, 2, 9 Babini E.... Luchinat C. (Structure 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Influence of calcium on the proteolytic degradation of the calmodulin-like skin protein (calmodulin-like protein 5) in psoriatic epidermis. (PubMed id 16689864)1, 9 MAchul B....Schmidt R. (Exp. Dermatol. 2006)
    5. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    6. Secreted calmodulin-like skin protein inhibits neuronal death in cell-based Alzheimer's disease models via the heterotrimeric Humanin receptor. (PubMed id 23519124)1 Hashimoto Y....Matsuoka M. (amp 2013)
    7. Specific expression of k63-linked ubiquitination of calmodulin-like protein 5 in breast cancer of premenopausal patients. (PubMed id 24146193)1 Debald M....Walgenbach-BrA1nagel G. (J. Cancer Res. Clin. Oncol. 2013)
    8. A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (Biochem. J. 2012)
    9. Viral immune modulators perturb the human molecular network by common and unique strategies. (PubMed id 22810585)1 Pichlmair A....Superti-Furga G. (Nature 2012)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51806 HGNC: 18180 AceView: CALML5 Ensembl:ENSG00000178372 euGenes: HUgn51806
    ECgene: CALML5 Kegg: 51806 H-InvDB: CALML5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CALML5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CALML5 gene:
    Search GeneIP for patents involving CALML5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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