CALML5 Gene
protein-coding GIFtS: 50
GCID: GC10M005530
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calmodulin-like 5
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Aliases
for CALML5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Calmodulin-Like 51 2 | | CLSP1 2 3 | | Calmodulin-Like Skin Protein2 3 | | Calmodulin-Like Protein 52 |
Export aliases for CALML5 gene to outside databasesPrevious GC identifer: GC10M005494 |
Summaries
for CALML5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CALML5:
This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family ofcalcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes aconformational change when it does so. Abundant expression is detected only in reconstructed epidermis and isrestricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a keyenzyme in the terminal differentiation of keratinocytes. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CALL5_HUMAN, Q9NZT1Function: Binds calcium. May be involved in terminal differentiation of keratinocytes
Gene Wiki entry for CALML5
|
Genomic Views
for CALML5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_008705.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CALML5 gene promoter:
p53 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) STAT5A CUTL1 POU3F2 LCR-F1 GATA-2 POU2F1a HSF2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CALML5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CALML5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10p15.1 Ensembl cytogenetic band: 10p15.1 HGNC cytogenetic band: 10p15.1CALML5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M005530: view genomic region
(about GC identifiers)
Start:
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5,540,658 bp from pter |
End:
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5,541,533 bp from pter |
Size:
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876 bases |
Orientation:
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minus strand |
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Proteins
for CALML5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CALL5_HUMAN, Q9NZT1 (See
protein sequence)Recommended Name: Calmodulin-like protein 5 Size: 146 amino acids; 15893 Da
Subunit: Associates with transglutaminase 3
1 PDB 3D structure from  and Proteopedia  for CALML5:2B1U (3D)
Secondary accessions: Q5SQI3 Q8IXU8Explore the universe of human proteins at neXtProt for CALML5: NX_Q9NZT1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NZT1
CALML5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_059118.2
ENSEMBL proteins: ENSP00000369689
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005625 | soluble fraction |
-- | -- |
CALML5 for ontologies About GeneDecksing
CALML5 Antibody Products:
Assay Products for CALML5: |
Protein
Domains /
Families
for CALML5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CALML5 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NZT1ProtoNet protein and cluster: Q9NZT1 UniProtKB/Swiss-Prot: CALL5_HUMAN, Q9NZT1Similarity: Contains 4 EF-hand domains |
Function
for CALML5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CALL5_HUMAN, Q9NZT1Function: Binds calcium. May be involved in terminal differentiation of keratinocytes
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CALML5 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CALML5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CALML5 (NM_017422) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CALML5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALML5 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005509 | calcium ion binding |
IEA | -- |
CALML5 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CALML5:
|
Pathways & Interactions
for CALML5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Gastric acid secretion | | | 2 | GnRH signaling pathway | | | 3 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 4 | Glioma | | | 5 | Tuberculosis | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for CALML5
5/17 
Kegg Pathways (Kegg details for CALML5) (see all 17):
CALML5 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CALML5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/78 Interacting proteins for CALML5 (Q9NZT13 ENSP000003696894) via UniProtKB, MINT, STRING, and/or I2D (see all 78)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
CALML5 for ontologies About GeneDecksing
|
Drugs & Compounds
for CALML5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CALML5
1 HMDB Compound for CALML5 About this table
Search CenterWatch for drugs/clinical trials and news about CALML5 / CALL5
|
Transcripts
for CALML5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CALML5 gene: NM_017422.4 Unigene Cluster for CALML5: Calmodulin-like 5 Hs.180142 [show with all ESTs]Unigene Representative Sequence: BG6763071 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000380332(uc001iic.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CALML5 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CALML5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CALML5 (NM_017422) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CALML5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALML5 |
Additional cDNA sequence: AF172852.1 AK222744.1 BC039172.1 1 DOTS entry: DT.106513 16 AceView cDNA sequences: BG680086 BG743203 AI791325 BG697492 BG676307 BC039172 NM_017422 AI791495 BG696865 AI791964 AI732667 AA601601 AI732539 AF172852 AA709067 AA505923
GeneLoc Exon Structure
|
Expression
for CALML5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CALML5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCCGCGAGG
About this image
See CALML5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CALML5
SOURCE GeneReport for Unigene cluster: Hs.180142
UniProtKB/Swiss-Prot: CALL5_HUMAN, Q9NZT1Tissue specificity: Particularly abundant in the epidermis where its expression is directly related to keratinocytedifferentiation. Very low expression in lung
SABiosciences Custom PCR Arrays for CALML5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CALML5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CALML5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALML5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALML5 |
Orthologs
for CALML5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CALML5 gene from 1/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG135266 |
-- |
27(a) |
1 → many |
2R(18642745-18643401) |
ENSEMBL Gene Tree for CALML5 (if available)
TreeFam Gene Tree for CALML5 (if available) |
Paralogs
for CALML5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CALML5 gene
- CALML32 CABP52 CABP12 TNNC12 CALM32 CABP42 CABP22 CALM12
- TNNC22 CALML62 CALML42 CABP72 CALN12 CALM22
18/25 SIMAP similar genes for CALML5 using alignment to 1 protein entry: CALL5_HUMAN(see all similar genes):CALM2 CALM3 CALM1 CALML3 CALN1 CETN2
TNNC2 CETN1 TNNC1 CABP1 MYL1 CETN3
CABP2 CALML4 MYL6 SLC25A24 CABP5 CALML6
CALML5 for paralogs About GeneDecksing
|
Genomic Variants
for CALML5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CALML5 (5540658 - 5541533 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CALML5: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CALML5 |
|
Disorders
/ Diseases
for CALML5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CALML5 for disorders About GeneDecksing
OMIM gene information: 605183
OMIM disorders: --
4  diseases for CALML5: About MalaCardsklebsiella pneumonia pertussis tuberculosis
Export disorders for CALML5 gene to outside databases
|
Publications
for CALML5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CALML5 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with CALML5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and cloning of a new calmodulin-like protein from human epidermis. (PubMed id 10777582)1, 2, 3, 9 Mehul B.... Schmidt R. (2000)
- A structural and dynamic characterization of the EF-hand protein CLSP. (PubMed id 16765896)1, 2, 9 Babini E.... Luchinat C. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Influence of calcium on the proteolytic degradation of the calmodulin-like skin protein (calmodulin-like protein 5) in psoriatic epidermis. (PubMed id 16689864)1, 9 Mehul B....Schmidt R. (2006)
- A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (2012)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- Detection and validation of non-synonymous coding SNPs from orthogonal analysis of shotgun proteomics data. (PubMed id 17488105)2 Bunger M.K.... Stephenson J.L. Jr. (2007)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
|
External Searches for CALML5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CALML5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CALML5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CALML5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CALML5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CALML5 gene:
Search GeneIP for patents involving CALML5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CALML5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CALML5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CALML5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CALML5 | | | OriGene Protein Over-expression Lysate for CALML5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CALML5 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CALML5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CALML5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CALML5 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CALML5 | | OriGene Custom Protein Services for CALML5 | | | OriGene Custom Immunoassay Development | | |
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 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CALML5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CALML5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CALML5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALML5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALML5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALML5 |
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| | | | Search Tocris compounds for CALML5 |
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 | | | CALML5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibody for CALML5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALML5 |
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