CALML4 Gene
protein-coding GIFtS : 45
GCID: GC15 M068483
calmodulin-like 4
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Aliasesfor CALML4 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Calmodulin-Like 4 1 2 NY-BR-201 2 Serologically Defined Breast Cancer Antigen NY-BR-202 3 MGC48091 Calmodulin-Like Protein 42
Export aliases for CALML4 gene to outside databases Previous GC identifers: GC15M066198 GC15M066270 GC15M045313
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Summariesfor CALML4 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor CALML4 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000015.9 NC_018926.1 NT_010194.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CALML4 gene promoter: STAT1 AP-1 STAT4 STAT1beta STAT5A CUTL1 STAT1alpha GATA-1 STAT2 STAT3 Other transcription factors Search SABiosciences Chromatin IP Primers for CALML4 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CALML4
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 15q23 Ensembl cytogenetic band: 15q23 HGNC cytogenetic band: 15q22.31 CALML4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 15 GeneLoc Exon Structure
GeneLoc location for GC15M068483: view genomic region
(about GC identifiers )
Start:
68,483,043 bp from pter
End:
68,498,448 bp from pter
Size:
15,406 bases
Orientation:
minus strand
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Proteinsfor CALML4 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CALL4_HUMAN, Q96GE6 (See
protein sequence )Recommended Name: Calmodulin-like protein 4 Size : 196 amino acids; 21883 Da
Sequence caution : Sequence=AAG48255.1; Type=Frameshift; Positions=Several; Sequence=BAG59377.1; Type=Erroneousinitiation;
Secondary accessions : B4DL15 Q6N048 Q9H286Alternative splicing : 3 isoforms : Q96GE6-1 Q96GE6-2 Q96GE6-3 Explore the universe of human proteins at neXtProt for CALML4: NX_Q96GE6 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q96GE6 CALML4 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001026903.2 NP_219501.2 ENSEMBL proteins: ENSP00000432629 ENSP00000378848 ENSP00000400755 ENSP00000435285 ENSP00000419081 ENSP00000456532 ENSP00000438177 Human Recombinant Protein Products: CALML4 Antibody Products: Assay Products for CALML4:
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Protein
Domains / Familiesfor CALML4 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
CALML4 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q96GE6 ProtoNet protein and cluster: Q96GE6
UniProtKB/Swiss-Prot: CALL4_HUMAN, Q96GE6 Similarity : Belongs to the calmodulin familySimilarity : Contains 4 EF-hand domains
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Functionfor CALML4 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CALML4 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CALML4 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): CALML4 (NM_033429 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CALML4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CALML4
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALML4
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005509 calcium ion binding
IEA --
CALML4 for ontologies About GeneDecksing 3 GenomeRNAi human phenotypes for CALML4 :
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Pathways & Interactionsfor CALML4 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CALML4
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Drugs & Compoundsfor CALML4 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for CALML4 Search CenterWatch for drugs/clinical trials and news about CALML4 / CALL4
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Transcriptsfor CALML4 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CALML4 gene (2 alternative transcripts): NM_001031733.2 NM_033429.2 Unigene Cluster for CALML4:
Calmodulin-like 4 Hs.709550 [show with all ESTs ] Unigene Representative Sequence: NM_033429 8 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000478113 ENST00000395465 (uc002arb.3 uc002arc.3 uc002ard.3 uc002are.3 uc010bhz.3 )ENST00000448060 ENST00000395463 ENST00000467188 ENST00000467889 ENST00000354678 ENST00000540479 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CALML4 (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CALML4 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): CALML4 (NM_033429 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CALML4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CALML4
Additional cDNA sequence: AF308287.1 AK092628.1 AK096198.1 AK296804.1 BC009516.2 BC015215.2 BX640817.1
11 DOTS entries : DT.97782925 DT.86821411
DT.406414 DT.121060515 DT.100781593 DT.121060512 DT.212554 DT.100781592 DT.121060506 DT.121060540 DT.75148774 24/345 AceView cDNA sequences (see all 345 ):
AX747637 BU679598 AA995083 BU683374 AA447765 AI560410 AI554557 BX640702 AI307668 CA455197 BM793802 CR598967 AI493009 AI754515 AI935982 BG026786 CD676818 AA281437 CA446197 AI651175 BQ027452 CD742719 BF064123 BU689640 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CALML4 (see all 6 ) About this scheme ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e SP1 :     -   -                 SP2 :       -                 SP3 :     -   -   -               SP4 :       -   -               SP5 :     -   -   -   -            
ECgene alternative splicing isoforms for CALML4
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Expression for CALML4 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CALML4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GTATGAGTAG
About this image CALML4 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 2 LifeMap In Vivo Development Anatomical Compartments/Cells Tissue Anatomical Compartment
Cell Category (developmental path) Eye Outer Nuclear Layer Mature Rod Cells Photoreceptors, Retina Brain Choroid Plexus Brain Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See CALML4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CALML4 SOURCE GeneReport for Unigene cluster: Hs.709550 UniProtKB/Swiss-Prot: CALL4_HUMAN, Q96GE6 Tissue specificity : Expressed in breast cancer cell lines SABiosciences Custom PCR Arrays for CALML4 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CALML4Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat CALML4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CALML4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CALML4 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALML4
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Orthologsfor CALML4 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for CALML4 gene from 5/18 species (see all 18 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
CALML41
calmodulin-like 4
68.63(n) 65.36(a)
 
427515 XM_425089.3 XP_425089.3
lizard (Anolis carolinensis)
Reptilia
CALML46
--
65(a)
1 ↔ 1
GL343467.1(735087-741986)
zebrafish (Danio rerio)
Actinopterygii
Dr.157362
Transcribed sequence with weak similarity to protein spP02593 (H.sapiens) CALM_HUMAN Calmodulin less
71.65(n)
 
AL924036.1
fruit fly (Drosophila melanogaster)
Insecta
CG172726 Eip63F-16
Ecdysone-induced protein 63F 1
38(a) 17(a)
1 ↔ 1possible ortholog
3R(16649035-16649951) 3L(3909973-3935617)
rice (Oryza sativa)
Liliopsida
--
OsCML9 - Calmodulin-related calcium sensor protein...
31(a)
possible ortholog
5(24067532-24068539)
ENSEMBL Gene Tree for CALML4 (if available)TreeFam Gene Tree for CALML4 (if available)
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Paralogsfor CALML4 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for CALML4 gene CALML3 2 CABP5 2 CABP1 2 TNNC1 2 CALM3 2 CABP4 2 CABP2 2 CALM1 2 TNNC2 2 CALML6 2 CALML5 2 CABP7 2 CALN1 2 CALM2 2 18/22 SIMAP similar genes for CALML4 using alignment to 5 protein entries: CALL4_HUMAN (see all proteins )
(see all similar genes ):DKFZp686D05174 CALM3 CALM2 CALML3 CALM1 MYL4 CALML5 CETN1 CETN2 TNNC1 MYL2 TNNC2 MYL6 CALML6 MRLC3 MYL12A MYL9 MYL12B
CALML4 for paralogs About GeneDecksing
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Genomic Variantsfor CALML4 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 15 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for CALML4 (68483043 - 68498448 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for CALML4: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CALML4
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Disorders
/ Diseasesfor CALML4 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
CALML4 for disorders About GeneDecksing 2 diseases for CALML4 : About MalaCards breast cancer gout Export disorders for CALML4 gene to outside databases
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Publicationsfor CALML4 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CALML4 gene integrated from 9 sources : (articles sorted by number of sources associating them with CALML4) Utopia : connect your pdf to the dynamic world of online information
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. (PubMed id 12747765) 1 , 2 Scanlan M.J.... Old L.J. (2001) The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005) 2 Bechtel S.... Schupp I. (2007) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171) 2 Zody M.C....Nusbaum C. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for CALML4 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CALML4 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CALML4 gene
(According to HUGE )
About This Section --
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Specialized Databases showing CALML4 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for CALML4 gene: Search GeneIP for patents involving CALML4 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CALML4 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for CALML4 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for CALML4 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CALML4 OriGene Protein Over-expression Lysate for CALML4 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for CALML4 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CALML4 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CALML4 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for CALML4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for CALML4 OriGene Custom Protein Services for CALML4 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CALML4 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CALML4 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CALML4 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat CALML4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CALML4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CALML4
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CALML4 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALML4
ThermoFisher Antibodies for CALML4
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CALML4
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Aliases for CALML4
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Disorders / Diseases for CALML4
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Expression for CALML4
Function for CALML4
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Pathways / Interactions for CALML4
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Transcripts for CALML4
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