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Aliases for CALML4 Gene

Aliases for CALML4 Gene

  • Calmodulin Like 4 2 3 5
  • Serologically Defined Breast Cancer Antigen NY-BR-20 3 4
  • Calmodulin-Like 4 2 3
  • NY-BR-20 3

External Ids for CALML4 Gene

Previous GeneCards Identifiers for CALML4 Gene

  • GC15M066198
  • GC15M066270
  • GC15M068483
  • GC15M045313

Summaries for CALML4 Gene

GeneCards Summary for CALML4 Gene

CALML4 (Calmodulin Like 4) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CABP2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALML4 Gene

Genomics for CALML4 Gene

Regulatory Elements for CALML4 Gene

Promoters for CALML4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CALML4 on UCSC Golden Path with GeneCards custom track

Genomic Location for CALML4 Gene

Chromosome:
15
Start:
68,190,705 bp from pter
End:
68,206,110 bp from pter
Size:
15,406 bases
Orientation:
Minus strand

Genomic View for CALML4 Gene

Genes around CALML4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALML4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALML4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALML4 Gene

Proteins for CALML4 Gene

  • Protein details for CALML4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GE6-CALL4_HUMAN
    Recommended name:
    Calmodulin-like protein 4
    Protein Accession:
    Q96GE6
    Secondary Accessions:
    • B4DL15
    • F8W6Y4
    • Q6MZY3
    • Q6N048
    • Q9H286

    Protein attributes for CALML4 Gene

    Size:
    196 amino acids
    Molecular mass:
    21883 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG48255.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=BAG59377.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CALML4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CALML4 Gene

Proteomics data for CALML4 Gene at MOPED

Post-translational modifications for CALML4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for CALML4

No data available for DME Specific Peptides for CALML4 Gene

Domains & Families for CALML4 Gene

Gene Families for CALML4 Gene

Protein Domains for CALML4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CALML4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96GE6

UniProtKB/Swiss-Prot:

CALL4_HUMAN :
  • Contains 4 EF-hand domains.
  • Belongs to the calmodulin family.
Domain:
  • Contains 4 EF-hand domains.
Family:
  • Belongs to the calmodulin family.
genes like me logo Genes that share domains with CALML4: view

Function for CALML4 Gene

genes like me logo Genes that share phenotypes with CALML4: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CALML4 Gene

Localization for CALML4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CALML4 Gene COMPARTMENTS Subcellular localization image for CALML4 gene
Compartment Confidence
cytosol 3
nucleus 3
golgi apparatus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CALML4 Gene

Pathways & Interactions for CALML4 Gene

SuperPathways for CALML4 Gene

No Data Available

Interacting Proteins for CALML4 Gene

Gene Ontology (GO) - Biological Process for CALML4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CALML4 Gene

Drugs & Compounds for CALML4 Gene

No Compound Related Data Available

Transcripts for CALML4 Gene

Unigene Clusters for CALML4 Gene

Calmodulin-like 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CALML4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e
SP1: - -
SP2: -
SP3: - - -
SP4: - -
SP5: - - - -
SP6:

Relevant External Links for CALML4 Gene

GeneLoc Exon Structure for
CALML4
ECgene alternative splicing isoforms for
CALML4

Expression for CALML4 Gene

mRNA expression in normal human tissues for CALML4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CALML4 Gene

This gene is overexpressed in Colon - Transverse (x8.0).

Protein differential expression in normal tissues from HIPED for CALML4 Gene

This gene is overexpressed in Plasma (27.3), Fetal gut (10.3), Liver (7.9), and Prostate (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CALML4 Gene



SOURCE GeneReport for Unigene cluster for CALML4 Gene Hs.709550

mRNA Expression by UniProt/SwissProt for CALML4 Gene

Q96GE6-CALL4_HUMAN
Tissue specificity: Expressed in breast cancer cell lines.
genes like me logo Genes that share expression patterns with CALML4: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for CALML4 Gene

Orthologs for CALML4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CALML4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CALML4 35
  • 88.45 (n)
  • 88.89 (a)
CALML4 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CALML4 35
  • 87.3 (n)
  • 86.39 (a)
CALML4 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Calml4 35
  • 86.06 (n)
  • 89.54 (a)
Calml4 16
Calml4 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CALML4 35
  • 98.81 (n)
  • 97.96 (a)
CALML4 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Calml4 35
  • 85.4 (n)
  • 88.89 (a)
oppossum
(Monodelphis domestica)
Mammalia CALML4 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CALML4 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves CALML4 35
  • 68.85 (n)
  • 65.36 (a)
CALML4 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CALML4 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia calml4 35
  • 66.23 (n)
  • 63.4 (a)
zebrafish
(Danio rerio)
Actinopterygii calml4a 35
  • 67.54 (n)
  • 67.32 (a)
Dr.15736 35
calml4a 36
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG30378 36
  • 28 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToOne
Species with no ortholog for CALML4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CALML4 Gene

ENSEMBL:
Gene Tree for CALML4 (if available)
TreeFam:
Gene Tree for CALML4 (if available)

Paralogs for CALML4 Gene

Paralogs for CALML4 Gene

genes like me logo Genes that share paralogs with CALML4: view

Variants for CALML4 Gene

Sequence variations from dbSNP and Humsavar for CALML4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs3803381 - 68,205,295(+) ACCGC(A/G)TTCAG nc-transcript-variant, reference, missense, utr-variant-5-prime
rs2280217 - 68,197,472(+) GACTC(G/T)TGAGT intron-variant, reference, missense
rs938640 -- 68,201,410(+) AGAGG(A/G)CTGCC intron-variant
rs2280216 -- 68,197,118(+) CACTA(A/G)ATGAA intron-variant
rs3743089 -- 68,198,157(-) GGGAA(G/T)TTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CALML4 Gene

Variant ID Type Subtype PubMed ID
nsv1581 CNV Insertion 18451855

Variation tolerance for CALML4 Gene

Residual Variation Intolerance Score: 65.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.23; 40.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CALML4 Gene

HapMap Linkage Disequilibrium report
CALML4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALML4 Gene

Disorders for CALML4 Gene

Relevant External Links for CALML4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CALML4

No disorders were found for CALML4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CALML4 Gene

Publications for CALML4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. (PMID: 23377640) (Am J Psychiatry 2013) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. (PMID: 12747765) Scanlan M.J. … Old L.J. (Cancer Immun. 2001) 3

Products for CALML4 Gene

Sources for CALML4 Gene

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