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CALM3 Gene

protein-coding   GIFtS: 65
GCID: GC19P047105

Calmodulin 3 (Phosphorylase Kinase, Delta)

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calmodulin 3 (Phosphorylase Kinase, Delta)1 2     CALML23
Prepro-Calmodulin 31 2     CAM3
HEL-S-722     CAM13
PHKD2     CAM23
PHKD32     CAM33
caM2     CAMB3
calmodulin2     CAMC3
Epididymis Secretory Protein Li 722     CAMIII3
CALM3     CaM3

External Ids:    HGNC: 14491   Entrez Gene: 8082   Ensembl: ENSG000001600147   OMIM: 1141835   UniProtKB: P621583   

Export aliases for CALM3 gene to outside databases

Previous GC identifers: GC19P047748 GC19P047495 GC19P051780 GC19P051797 GC19P051798 GC19P051799 GC19P043529


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CALM3 Gene:
CALM3 (calmodulin 3 (phosphorylase kinase, delta)) is a protein-coding gene. Diseases associated with CALM3 include otomycosis, and pseudoachondroplasia. GO annotations related to this gene include ion channel binding and calcium ion binding. An important paralog of this gene is CALML3.

UniProtKB/Swiss-Prot: CALM_HUMAN, P62158
Function: Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other
proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein
kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the
centrosome cycle and progression through cytokinesis

Gene Wiki entry for CALM3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CALM3 gene promoter:
         STAT5B   SRF   SRF (504 AA)   MyoD   C/EBPalpha   GATA-1   CHOP-10   Max   AREB6   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CALM3 promoter sequence
   Search Chromatin IP Primers for CALM3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CALM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2-q13.3   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.2-q13.3

CALM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALM3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P047105:  view genomic region     (about GC identifiers)

Start:
47,104,331 bp from pter      End:
47,114,050 bp from pter
Size:
9,720 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CALM_HUMAN, P62158 (See protein sequence)
Recommended Name: Calmodulin  
Size: 149 amino acids; 16838 Da
Subunit: Interacts with MYO1C and RRAD. Interacts with MYO10 (By similarity). Interacts with CEP97, CCP110,
TTN/titin and SRY. Interacts with USP6; the interaction is calcium dependent. Interacts with CDK5RAP2. Interacts
with SCN5A. Interacts with RYR1 and RYR2. Interacts with FCHO1. Interacts with MIP in a 1:2 stoichiometry; the
interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure
Miscellaneous: This protein has four functional calcium-binding sites
Sequence caution: Sequence=CAA36839.1; Type=Erroneous gene model prediction;
Selected PDB 3D structures from and Proteopedia for CALM3 (see all 84):
1AJI (3D)        1CDL (3D)        1CLL (3D)        1CTR (3D)        1IWQ (3D)        1J7O (3D)    
Secondary accessions: P02593 P70667 P99014 Q13942 Q53S29 Q61379 Q61380 Q96HK3

Explore the universe of human proteins at neXtProt for CALM3: NX_P62158

Explore proteomics data for CALM3 at MOPED

Post-translational modifications: 

  • Ubiquitination results in a strongly decreased activity (By similarity)1
  • Phosphorylation results in a decreased activity (By similarity)1
  • Ubiquitination2 at Lys14, Lys31, Lys95
  • Modification sites at PhosphoSitePlus

  • See CALM3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005175.2  
    ENSEMBL proteins: 
     ENSP00000375785   ENSP00000291295   ENSP00000470308   ENSP00000470502   ENSP00000468877  
     ENSP00000471225   ENSP00000472141  
    Reactome Protein details: P62158

    CALM3 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CALM3 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CALM3
    OriGene Protein Over-expression Lysate for CALM3
    OriGene MassSpec for CALM3
    OriGene Custom Protein Services for CALM3
    GenScript Custom Purified and Recombinant Proteins Services for CALM3
    Novus Biologicals CALM3 Proteins
    Novus Biologicals CALM3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CALM3

    CALM3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CALM3
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CALM3
    OriGene Custom Antibody Services for CALM3
    Novus Biologicals CALM3 Antibodies
    Abcam antibodies for CALM3
    Cloud-Clone Corp. Antibodies for CALM3
    Search ThermoFisher Antibodies for CALM3
    LSBio Antibodies in human, mouse, rat for CALM3

    CALM3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CALM3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CALM3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CALM3
    Cloud-Clone Corp. CLIAs for CALM3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    EFHAND: EF-hand domain containing

    4 InterPro protein domains:
     IPR001125 Recoverin_like
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry P62158

    ProtoNet protein and cluster: P62158

    UniProtKB/Swiss-Prot: CALM_HUMAN, P62158
    Similarity: Belongs to the calmodulin family
    Similarity: Contains 4 EF-hand domains


    CALM3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CALM_HUMAN, P62158
    Function: Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other
    proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein
    kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the
    centrosome cycle and progression through cytokinesis

         Genatlas biochemistry entry for CALM3:
    calmodulin 3,calcium modulated protein

         Gene Ontology (GO): Selected molecular function terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding ISS--
    GO:0005515protein binding IPI10692436
    GO:0008179adenylate cyclase binding IEA--
    GO:0016301kinase activity ----
    GO:0019904protein domain specific binding IPI11984006
         
    CALM3 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for CALM3:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Increased gamma-H2AX phosphory  Increases Tamoxifen sensitivit 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CALM3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CALM3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CALM3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CALM3

    miRNA
    Products:
        
    miRTarBase miRNAs that target CALM3:
    hsa-mir-320a (MIRT044685), hsa-mir-7-5p (MIRT025949), hsa-mir-27b-3p (MIRT046170), hsa-mir-1 (MIRT004467)

    Block miRNA regulation of human, mouse, rat CALM3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CALM3 (see all 55):
    hsa-miR-361-5p hsa-miR-513a-5p hsa-miR-938 hsa-miR-25 hsa-miR-29a hsa-miR-765 hsa-miR-486-3p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidCALM3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CALM3
    Predesigned siRNA for gene silencing in human, mouse, rat CALM3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CALM3

    Clone
    Products:
         
    OriGene clones in human, mouse for CALM3 (see all 6)
    OriGene ORF clones in mouse, rat for CALM3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CALM3 (NM_005184)
    Sino Biological Human cDNA Clone for CALM3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALM3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CALM3
    Browse ESI BIO Cell Lines and PureStem Progenitors for CALM3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALM3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CALM_HUMAN, P62158: Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed
    throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and
    the spindle microtubules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol4
    extracellular4
    nucleus4
    endoplasmic reticulum3
    golgi apparatus2
    mitochondrion2
    vacuole2
    chloroplast1
    endosome1
    lysosome1

    Gene Ontology (GO): Selected cellular component terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IDA16760425
    GO:0005576extracellular region TAS--
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm TAS10899953

    CALM3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CALM3 About   (see all 102)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Ca-dependent events
    DAG and IP3 signaling0.94
    PLC beta mediated events0.67
    EGFR interacts with phospholipase C-gamma0.94
    G-protein mediated events0.65
    PLC-gamma1 signalling0.94
    Phospholipase C-mediated cascade0.59
    CaM pathway0.93
    Opioid Signalling0.54
    2Post NMDA receptor activation events
    Post NMDA receptor activation events0.90
    CREB phosphorylation through the activation of CaMKII0.00
    Activation of NMDA receptor upon glutamate binding and postsynaptic events0.90
    Activation of CaMK IV0.00
    CREB phosphorylation through the activation of Ras0.78
    CaMK IV-mediated phosphorylation of CREB0.00
    Long-term potentiation0.35
    CREB phosphorylation through the activation of CaMKK0.00
    3Development Endothelin 1 EDNRA signaling
    Development Endothelin 1 EDNRA signaling0.41
    GnRH signaling pathway0.38
    Development Endothelin 1 EDNRA transactivation of EGFR0.41
    Inflammatory mediator regulation of TRP channels0.37
    Cytoskeleton remodeling FAK signaling0.41
    Estrogen signaling pathway0.34
    4fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    Signal transduction Activation of PKC via G Protein coupled receptor0.42
    VEGF and S-1P Signaling0.44
    Alpha-Adrenergic Signaling0.38
    fMLP Pathway0.43
    5ADP signalling through P2Y purinoceptor 12
    Activation of Kainate Receptors upon glutamate binding0.68
    Activation of Ca-permeable Kainate Receptor0.35
    Development Angiotensin signaling via beta Arrestin0.39
    Ionotropic activity of Kainate Receptors0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CALM3 (see all 41)
        Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods
    PI3K Signaling in B-Lymphocyte
    Dopamine-DARPP32 Feedback onto cAMP Pathway
    Alpha-Adrenergic Signaling

    Selected GeneGo (Thomson Reuters) Pathways for CALM3 (see all 35)
        Signal transduction cAMP signaling
    Development Endothelin-1/EDNRA signaling
    Immune response CD28 signaling
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Signal transduction Activation of PKC via G-Protein coupled receptor

    Selected BioSystems Pathways for CALM3 (see all 25)
        Myometrial Relaxation and Contraction Pathways
    MicroRNAs in cardiomyocyte hypertrophy
    G13 Signaling Pathway
    G Protein Signaling Pathways
    Glycogen Metabolism


    Selected Reactome Pathways for CALM3 (see all 22)
        Glycogen breakdown (glycogenolysis)
    Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
    Inactivation, recovery and regulation of the phototransduction cascade
    DARPP-32 events
    Activation of CaMK IV


    Selected Kegg Pathways  (Kegg details for CALM3) (see all 27):
        Ras signaling pathway
    Rap1 signaling pathway
    Calcium signaling pathway
    Phosphatidylinositol signaling system
    Oocyte meiosis


    CALM3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CALM3
    Interactions:

        Search GeneGlobe Interaction Network for CALM3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CALM3 (P621581, 2, 3 ENSP000002912954) via UniProtKB, MINT, STRING, and/or I2D (see all 640)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CACNA1CQ139361, 2, 3EBI-397435,EBI-1038838 MINT-8087834 MINT-8087891 MINT-8087783 MINT-8087930 MINT-8087912 MINT-8087767 MINT-8087800 MINT-8087819 MINT-8087850 MINT-8087867 I2D: score=6 
    MYO10Q9HD671, 2, 3, ENSP000003911064EBI-397435,EBI-307061 MINT-6595938 MINT-6596013 I2D: score=3 STRING: ENSP00000391106
    KCNH1O952591, 2, 3EBI-397435,EBI-2909270 MINT-7988123 MINT-7988100 I2D: score=3 
    RCHY1Q96PM51, 2, 3EBI-397435,EBI-947779 MINT-5114562 MINT-5114545 I2D: score=2 
    YWHAZP631041, 2, 3EBI-397435,EBI-347088 MINT-7899812 MINT-3295975 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 46):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001975response to amphetamine IEA--
    GO:0002027regulation of heart rate IMP--
    GO:0002576platelet degranulation TAS--
    GO:0005513detection of calcium ion IMP--
    GO:0005975carbohydrate metabolic process TAS--

    CALM3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CALM3 (CALM)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CALM3 gene: 
    NM_005184.2  

    Unigene Cluster for CALM3:

    Calmodulin 3 (phosphorylase kinase, delta)
    Hs.515487  [show with all ESTs]
    Unigene Representative Sequence: AK094964
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391918 ENST00000291295(uc002pew.3 uc010ekp.3 uc010xyc.2)
    ENST00000597743 ENST00000477244 ENST00000598871 ENST00000602169 ENST00000594523
    ENST00000597868 ENST00000599839 ENST00000596362 ENST00000482455 ENST00000486500
    ENST00000595072
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CALM3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CALM3 (see all 55):
    hsa-miR-361-5p hsa-miR-513a-5p hsa-miR-938 hsa-miR-25 hsa-miR-29a hsa-miR-765 hsa-miR-486-3p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidCALM3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CALM3
    Predesigned siRNA for gene silencing in human, mouse, rat CALM3
    Clone
    Products:
         
    OriGene clones in human, mouse for CALM3 (see all 6)
    OriGene ORF clones in mouse, rat for CALM3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CALM3 (NM_005184)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALM3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CALM3
    OriGene qSTAR qPCR primer pairs in human, mouse for CALM3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CALM3
      QuantiTect SYBR Green Assays in human, mouse, rat CALM3
      QuantiFast Probe-based Assays in human, mouse, rat CALM3

    Additional mRNA sequence: 

    AK094964.1 AK124456.1 AK295927.1 AK310762.1 AL050207.1 BC005137.2 BC006182.1 BT006855.1 
    J04046.1 

    Selected DOTS entries (see all 71):

    DT.97864702  DT.95237912  DT.101985876  DT.100041378  DT.100887267  DT.87018048  DT.100887283  DT.92036375 
    DT.95226396  DT.100887294  DT.91722585  DT.92011535  DT.95237965  DT.97862986  DT.100045324  DT.100045322 
    DT.100887285  DT.121469377  DT.91802787  DT.121469381  DT.100758537  DT.100887311  DT.100887307  DT.91762799 

    Selected AceView cDNA sequences (see all 1153):

    BQ049883 AJ706927 CR604087 BU623836 BX441420 AW498616 BU154024 CB155198 
    CD620032 BQ720734 BG910560 BF953883 BM469393 CB148700 BQ055565 BQ674240 
    CR616035 BG393570 BE260353 AA295748 H14317 BF894566 BQ229481 AA455818 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CALM3 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9
    SP1:        -     -     -     -                                                                     
    SP2:              -     -     -                                                                     
    SP3:              -     -     -                                         -     -                     
    SP4:              -     -     -                                                                     
    SP5:              -     -     -                                                                     


    ECgene alternative splicing isoforms for CALM3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CALM3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCCGTGCCC
    CALM3 Expression
    About this image


    CALM3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Lung (Respiratory System)
             Stem Bronchi
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
    CALM3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CALM3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515487
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CALM3 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Calm35 calmodulin 3   --   7 (9.15 cM) 16915379 
    chicken
    (Gallus gallus)
    Aves CALM11 calmodulin 1 (phosphorylase kinase, delta) 82.55(n)
    99.33(a)
      396523  NM_001110364.1  NP_001103834.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    99(a)
    100(a)
    many ↔ many
    many ↔ many
    GL343568.1(347088-358586)
    GL343739.1(54024-70590)
    zebrafish
    (Danio rerio)
    Actinopterygii BC059500.12   -- 84.97(n)   368217  BC059500.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cam3 calcium ion sensing calcium ion binding 96(a)
    (best of 5)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea cmd-13 calmodulin 96(a)
    (best of 6)
      V(1156006-1157085)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CAM71 CAM7 78.08(n)
    89.93(a)
      823492  NM_114249.3  NP_189967.1 
    rice
    (Oryza sativa)
    Liliopsida Os.102902 O.sativa mRNA for calmodulin 80.73(n)    AF042839.1 


    ENSEMBL Gene Tree for CALM3 (if available)
    TreeFam Gene Tree for CALM3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CALM3 gene
    CALM11 2  CALM21 2  CALML32  CABP52  CABP12  TNNC12  CABP42  CABP22  
    CALML62  TNNC22  CALML52  CALML42  
    Selected SIMAP similar genes for CALM3 using alignment to 3 protein entries:     CALM_HUMAN (see all proteins) (see all similar genes):
    CALM2    CALM1    CALML3    CALML5    TNNC2    CETN1
    CETN2    TNNC1    CABP5    CALML6    CALN1    CABP1
    MYL1    MYL12B    MYL9    MYL4    CABP2    CALML4

    CALM3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CALM3 (see all 203)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1907467661,2
    --47106462(+) GACACA/GGACCT 1 -- int10--------
    rs1809186951,2
    --47106463(+) ACACAA/GACCTG 1 -- int10--------
    rs1429952901,2
    C--47106483(+) TTGCC-/TGCTAC 1 -- int10--------
    rs1851774791,2
    --47106483(+) CTTGCC/GGCTAC 1 -- int10--------
    rs1499889521,2
    C--47106584(+) AACTAA/GTTTCT 1 -- int10--------
    rs43801461,2
    C,F,A,H--47106634(+) CACTGT/GTAACT 1 -- int124Minor allele frequency- G:0.15NS EA NA WA CSA 2351
    rs1896849621,2
    C--47106683(+) GGCCCA/GGGTGA 1 -- int10--------
    rs1138957901,2
    C,F--47106810(+) CTTGTC/TCAGCC 1 -- int10--------
    rs1452094381,2
    C--47107307(+) GGCTCA/GCTTTT 1 -- int10--------
    rs1863244231,2
    --47107493(+) CCTAAA/GGGATG 1 -- int10--------

    HapMap Linkage Disequilibrium report for CALM3 (47104331 - 47114050 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CALM3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3961n71CNV Loss21882294
    nsv833849CNV Loss17160897

    Human Gene Mutation Database (HGMD): CALM3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CALM3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 114183    OMIM disorders: --

    UniProtKB/Swiss-Prot: CALM_HUMAN, P62158
  • Ventricular tachycardia, catecholaminergic polymorphic, 4 (CPVT4) [MIM:614916]: An arrhythmogenic
    disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac
    arrest and cause sudden death. Patients present with recurrent syncope, seizures, or sudden death after physical
    activity or emotional stress. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • Selected diseases for CALM3 (see all 27):    
    About MalaCards
    otomycosis    pseudoachondroplasia    senior-loken syndrome    multiple epiphyseal dysplasia
    malignant hyperthermia    familial hypertrophic cardiomyopathy    hypertrophic cardiomyopathy    toxic encephalopathy
    lissencephaly    pertussis    brain disease    vascular disease
    cholera    hiv-1    ataxia    tuberculosis
    inflammatory bowel disease    retinitis    alzheimer's disease    obesity

    8 diseases from the University of Copenhagen DISEASES database for CALM3:
    Vascular disease     Cholera     Cancer     Pertussis
    Toxic encephalopathy     Otomycosis     Pseudoachondroplasia     Malignant hyperthermia

    CALM3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CALM3
    Human Genome Epidemiology (HuGE) Navigator: CALM3 (8 documents)

    Export disorders for CALM3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CALM3 gene, integrated from 10 sources (see all 145):
    (articles sorted by number of sources associating them with CALM3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    2. A new polymorphism in human calmodulin III gene promoter is a potential modifier gene for familial hypertrophic cardiomyopathy. (PubMed id 19429631)1, 4 Friedrich F.W....Carrier L. (Eur. Heart J. 2009)
    3. Cep97 and CP110 suppress a cilia assembly program. (PubMed id 17719545)1, 2 Spektor A.... Dynlacht B.D. (Cell 2007)
    4. CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability. (PubMed id 16760425)1, 2 Tsang W.Y.... Dynlacht B.D. (Mol. Biol. Cell 2006)
    5. Insights into voltage-gated calcium channel regulation from the structure of the CaV1.2 IQ domain-Ca2+/calmodulin complex. (PubMed id 16299511)1, 2 Van Petegem F.... Minor D.L. Jr. (Nat. Struct. Mol. Biol. 2005)
    6. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    7. Calcium/calmodulin regulates ubiquitination of the ubiquitin-specific protease TRE17/USP6. (PubMed id 16127172)1, 2 Shen C.... Chou M.M. (J. Biol. Chem. 2005)
    8. Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor. (PubMed id 15719022)1, 2 Shen Y.... Tang W.-J. (EMBO J. 2005)
    9. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    10. Defective calmodulin-mediated nuclear transport of the sex- determining region of the Y chromosome (SRY) in XY sex reversal. (PubMed id 15746192)1, 2 Sim H.... Harley V.R. (Mol. Endocrinol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 808 HGNC: 1449 AceView: CALM3 Ensembl:ENSG00000160014 euGenes: HUgn808
    ECgene: CALM3 Kegg: 808 H-InvDB: CALM3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CALM3 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/105

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CALM3 gene:
    Search GeneIP for patents involving CALM3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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