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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CALM3 Gene

protein-coding GIFtS: 64
GCID: GC19P047105

calmodulin 3 (phosphorylase kinase, delta)

Explore 24 diseases affiliated with
CALM3 via

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Calmodulin 3 (Phosphorylase Kinase, Delta)¹ ²		CAM³
PHKD¹ ²		CAM1³
PHKD3²		CAM2³
CaM³		CAM3³
Calmodulin¹		CAMB³
Prepro-Calmodulin 3²		CAMC³
CALM³		CAMIII³
CALML2³		CaM³

External Ids:	HGNC: 1449¹	Entrez Gene: 808²	Ensembl: ENSG00000160014⁷	OMIM: 114183⁵	UniProtKB: P62158³

Export aliases for CALM3 gene to outside databases

Previous GC identifers: GC19P047748 GC19P047495 GC19P051780 GC19P051797 GC19P051798 GC19P051799 GC19P043529

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CALM_HUMAN, P62158

Function: Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+).

Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.

Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression

through cytokinesis

Gene Wiki entry for CALM3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CALM3 gene promoter:
STAT5B SRF SRF (504 AA) MyoD C/EBPalpha GATA-1 CHOP-10 Max AREB6 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CALM3 promoter sequence

Search SABiosciences Chromatin IP Primers for CALM3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CALM3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2-q13.3 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.2-q13.3

CALM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALM3 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P047105: view genomic region (about GC identifiers)

Start:	47,104,512 bp from pter	End:	47,114,039 bp from pter
Size:	9,528 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CALM_HUMAN, P62158 (See protein sequence)

Recommended Name: Calmodulin

Size: 149 amino acids; 16838 Da

Subunit: Interacts with MYO1C and RRAD. Interacts with MYO10 (By similarity). Interacts with CEP97, CEP110, TTN/titin

and SRY. Interacts with USP6; the interaction is calcium dependent. Interacts with CDK5RAP2. Interacts with SCN5A.

Interacts with RYR1 and RYR2. Interacts with FCHO1

Subcellular location: Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed

throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the

spindle microtubules

Miscellaneous: This protein has four functional calcium-binding sites

Sequence caution: Sequence=CAA36839.1; Type=Erroneous gene model prediction;

6/76 PDB 3D structures from and Proteopedia for CALM3 (see all 76):

1AJI (3D)

1CDL (3D)

1CLL (3D)

1CTR (3D)

1IWQ (3D)

1J7O (3D)

Secondary accessions: P02593 P70667 P99014 Q13942 Q53S29 Q61379 Q61380 Q96HK3

Explore the universe of human proteins at neXtProt for CALM3: NX_P62158

Post-translational modifications:

Ubiquitination results in a strongly decreased activity (By similarity)¹

Phosphorylation results in a decreased activity (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P62158

CALM3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005175.2

ENSEMBL proteins:

ENSP00000291295 ENSP00000375785

Reactome Protein details: P62158
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant CALM3 Protein
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CALM3 OriGene Protein Over-expression Lysate: CALM3 OriGene Custom Protein Services for CALM3
	GenScript Custom Purified and Recombinant Proteins Services for CALM3
	Novus Biologicals CALM3 Proteins Novus Biologicals CALM3 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CALM3

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000922	spindle pole	IDA	16760425
GO:0005576	extracellular region	TAS	--
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	TAS	10899953
GO:0005813	centrosome	IDA	16760425

CALM3 for ontologies About GeneDecksing

CALM3 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CALM3
	Browse R&D Systems for Antibodies
	OriGene Antibodies: CALM3 OriGene Custom Antibody Services for CALM3
	GenScript Custom Superior Antibodies Services for CALM3
	Novus Biologicals CALM3 Antibodies
	Abcam antibodies for CALM3
	Uscn Antibodies for CALM3
	Search ThermoFisher Antibodies for CALM3

Assay Products for CALM3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CALM3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CALM3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CALM3 for domains About GeneDecksing

4 InterPro domains/families:

IPR001125 Recoverin

IPR011992 EF-hand-like_dom

IPR002048 EF_hand_Ca-bd

IPR018247 EF_Hand_1_Ca_BS

Graphical View of Domain Structure for InterPro Entry P62158

ProtoNet protein and cluster: P62158

UniProtKB/Swiss-Prot: CALM_HUMAN, P62158

Similarity: Belongs to the calmodulin family

Similarity: Contains 4 EF-hand domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CALM_HUMAN, P62158

Function: Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+).

Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.

Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression

through cytokinesis

Genatlas biochemistry entry for CALM3:

calmodulin 3,calcium modulated protein

miRNA Products:		miRTarBase miRNAs that target CALM3: hsa-mir-1 (MIRT004467)

		OriGene 3'-UTR Clone: CALM3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALM3
		8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate CALM3 (see all 55):
		hsa-miR-361-5p hsa-miR-513a-5p hsa-miR-938 hsa-miR-25 hsa-miR-29a hsa-miR-765 hsa-miR-486-3p hsa-miR-570

		SwitchGear 3'UTR luciferase reporter plasmid: CALM3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CALM3 (see all 7) OriGene shRNA RFP: CALM3 OriGene siRNA: CALM3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALM3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CALM3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CALM3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CALM3 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CALM3 (NM_005184)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALM3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALM3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CALM3
		Search LifeMap BioReagents cell lines for CALM3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALM3

Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	ISS	--
GO:0005515	protein binding	IPI	18567582
GO:0016301	kinase activity	--	--
GO:0019904	protein domain specific binding	IPI	11984006
GO:0031432	titin binding	IPI	7607248

CALM3 for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for CALM3:

Downregulation of NF-kappaB pa

Increased gamma-H2AX phosphory

Increases Tamoxifen sensitivit

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/86 super-pathways (see all 86) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Development Angiotensin activation of ERK

Development Angiotensin activation of ERK	1.00	Development ACM2 and ACM4 activation of ERK	0.74
Development_Angiotensin activation of ERK	0.98	Development_G-Proteins mediated regulation MARK-ERK signaling	0.66
Development_ACM2 and ACM4 activation of ERK	0.74	Development G-Proteins mediated regulation MARK-ERK signaling	0.66

Development_Endothelin-1/EDNRA transactivation of EGFR

Development_Endothelin-1/EDNRA transactivation of EGFR	1.00	Development_Endothelin-1/EDNRA signaling	0.41
Development Endothelin-1/EDNRA transactivation of EGFR	1.00	Cytoskeleton remodeling_FAK signaling	0.41
Development Endothelin-1/EDNRA signaling	0.41	Cytoskeleton remodeling FAK signaling	0.41

Translation_Translation regulation by Alpha-1 adrenergic receptors

	Translation_Translation regulation by Alpha-1 adrenergic receptors	1.00			Development_Activation of ERK by Alpha-1 adrenergic receptors	0.64
	Translation Translation regulation by Alpha-1 adrenergic receptors	1.00			Development Activation of ERK by Alpha-1 adrenergic receptors	0.64

Cytoskeleton remodeling_RalB regulation pathway

	Cytoskeleton remodeling RalB regulation pathway	1.00			Cytoskeleton remodeling_RalA regulation pathway	0.23
	Cytoskeleton remodeling_RalB regulation pathway	1.00			Cytoskeleton remodeling RalA regulation pathway	0.23

Sweet Taste Signaling

	Sweet Taste Signaling	1.00			Cellular Effects of Sildenafil	0.46
	Melatonin Signaling	0.72			Sperm Motility	0.36

Pathway sources
See GeneCards unified pathways
Show all pathways

5/36 EMD Millipore Pathways for CALM3 (see all 36)

	Translation Translation regulation by Alpha-1 adrenergic receptors
	Development Activation of ERK by Alpha-1 adrenergic receptors
	Immune response CD16 signaling in NK cells
	Cytoskeleton remodeling RalB regulation pathway
	Cytoskeleton remodeling FAK signaling

5/41 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CALM3 (see all 41)

	Intracellular Calcium Signaling
	Visual Cycle in Retinal Rods
	PI3K Signaling in B-Lymphocyte
	Dopamine-DARPP32 Feedback onto cAMP Pathway
	Alpha-Adrenergic Signaling

5/35 GeneGo (Thomson Reuters) Pathways for CALM3 (see all 35)

	Signal transduction cAMP signaling
	Development Endothelin-1/EDNRA signaling
	Immune response CD28 signaling
	Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
	Signal transduction Activation of PKC via G-Protein coupled receptor

5/25 BioSystems Pathways for CALM3 (see all 25)

	Myometrial Relaxation and Contraction Pathways
	G13 Signaling Pathway
	MicroRNAs in cardiomyocyte hypertrophy
	Calcium Regulation in the Cardiac Cell
	G Protein Signaling Pathways

5/66 Reactome Pathways for CALM3 (see all 66)

	Glycogen breakdown (glycogenolysis)
	Inositol phosphate metabolism
	Activation of CaMK IV
	Signaling by PDGF
	Activation of NMDA receptor upon glutamate binding and postsynaptic events

5/17 Kegg Pathways (Kegg details for CALM3) (see all 17):

	Calcium signaling pathway
	Phosphatidylinositol signaling system
	Oocyte meiosis
	Vascular smooth muscle contraction
	Long-term potentiation

CALM3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CALM3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/547 Interacting proteins for CALM3 (P62158^{1, 2, 3} ENSP00000291295⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 547)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CACNA1C	Q13936¹^,²^,³	EBI-397435,EBI-1038838 MINT-8087834 MINT-8087891 MINT-8087783 MINT-8087930 MINT-8087912 MINT-8087767 MINT-8087800 MINT-8087819 MINT-8087850 MINT-8087867 I2D: score=6
KCNH1	O95259¹^,²^,³	EBI-397435,EBI-2909270 MINT-7988123 MINT-7988100 I2D: score=3
FKBP8	Q14318²^,³	MINT-58231 MINT-58233 MINT-58242 MINT-58244 I2D: score=4
RALA	P11233²^,³	MINT-15766 MINT-15764 MINT-15765 I2D: score=4
RALB	P11234²^,³	MINT-16957 MINT-16956 MINT-16955 I2D: score=4

About this table

Gene Ontology (GO): 5/31 biological process terms (GO ID links to tree view) (see all 31): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002027	regulation of heart rate	IMP	--
GO:0002576	platelet degranulation	TAS	--
GO:0005513	detection of calcium ion	IMP	--
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0005980	glycogen catabolic process	TAS	--

CALM3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CALM3
Search CenterWatch for drugs/clinical trials and news about CALM3 / CALM

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CALM3 gene:

NM_005184.2

Unigene Cluster for CALM3:

Calmodulin 3 (phosphorylase kinase, delta)

Hs.515487 [show with all ESTs]

Unigene Representative Sequence: AK094964

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000477244 ENST00000291295(uc002pew.3 uc010ekp.3 uc010xyc.2)

ENST00000391918 ENST00000482455 ENST00000486500

miRNA Products:		OriGene 3'-UTR Clone: CALM3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALM3
		8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate CALM3 (see all 55):
		hsa-miR-361-5p hsa-miR-513a-5p hsa-miR-938 hsa-miR-25 hsa-miR-29a hsa-miR-765 hsa-miR-486-3p hsa-miR-570

		SwitchGear 3'UTR luciferase reporter plasmid: CALM3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CALM3 (see all 7) OriGene shRNA RFP: CALM3 OriGene siRNA: CALM3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALM3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CALM3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CALM3 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CALM3 (NM_005184)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALM3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALM3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CALM3 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALM3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALM3

Additional cDNA sequence:

AK094964.1 AK124456.1 AK295927.1 AK310762.1 AL050207.1 BC005137.2 BC006182.1 BT006855.1

J04046.1

24/71 DOTS entries (see all 71):

DT.97864702 DT.95237912 DT.101985876 DT.100041378 DT.87018048 DT.100887267 DT.100887283 DT.92036375

DT.95226396 DT.91722585 DT.100887294 DT.92011535 DT.95237965 DT.97862986 DT.100045324 DT.100045322

DT.100887285 DT.121469377 DT.91802787 DT.100758537 DT.121469381 DT.100887311 DT.100887307 DT.91762799

24/1153 AceView cDNA sequences (see all 1153):

CK905948 BM466396 BQ722712 BX645356 BM928808 BQ438076 BE262263 AA376590

BQ929461 CB850957 BQ270655 CB044678 CA438508 CD519082 BE885440 BQ272313

CB153679 BQ895901 BQ723151 BM856244 BM905955 BU187154 BX441969 CR603846

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for CALM3 (see all 12) About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	·	3c	·	3d	^	4a	·	4b	^	5a	·	5b	·	5c	^	6	^	7	^	8	^	9
SP1:			-		-		-		-
SP2:					-		-		-
SP3:					-		-		-														-		-
SP4:					-		-		-
SP5:					-		-		-

ECgene alternative splicing isoforms for CALM3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CALM3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCCGTGCCC

About this image
See CALM3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CALM3

SOURCE GeneReport for Unigene cluster: Hs.515487

SABiosciences Custom PCR Arrays for CALM3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CALM3 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALM3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALM3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALM3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CALM3 gene from 7/32 species (see all 32) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CALM1¹	calmodulin 1 (phosphorylase kinase, delta)	82.55(n) 99.33(a)		396523 NM_001110364.1 NP_001103834.1
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	--	99(a) 67(a) (see all 3)	possible ortholog possible ortholog (see all 3)	GL343568.1(347088-358586) GL343728.1(65478-65930)
zebrafish (Danio rerio)	Actinopterygii	BC059500.1²	--	84.97(n)		368217 BC059500.1
fruit fly (Drosophila melanogaster)	Insecta	Cam^{1 , 3}	calcium ion sensing calcium ion binding³ Calmodulin¹	96(a) (best of 5)³ 81.21(n)¹ 97.99(a)¹		36329¹ NM_078986.2¹ NP_523710.1¹
worm (Caenorhabditis elegans)	Secernentea	cmd-1^{1 , 3}	calmodulin³ Protein CMD-1¹	96(a) (best of 6)³ 80.76(n)¹ 97.99(a)¹		V(1156006-1157085)³ 178614¹ NM_070985.4¹ NP_503386.1¹
thale cress (Arabidopsis thaliana)	eudicotyledons	CAM4¹	calmodulin 4	76.51(n) 89.26(a)		842959 NM_105312.3 NP_176814.1
rice (Oryza sativa)	Liliopsida	Os.10290²	O.sativa mRNA for calmodulin	80.73(n)		AF042839.1

ENSEMBL Gene Tree for CALM3 (if available)
TreeFam Gene Tree for CALM3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CALM3 gene

CALM1¹ ² CALM2¹ ² CALML3² CABP5² CABP1² TNNC1² CABP4² CABP2²

TNNC2² CALML6² CALML5² CALML4² CABP7² CALN1²

18/59 SIMAP similar genes for CALM3 using alignment to 3 protein entries: CALM_HUMAN (see all proteins) (see all similar genes):

CALM1 CALM2 CALML3 CALML5 CETN1 CETN2

TNNC2 TNNC1 GPD2 CABP1 CABP5 CABP2

CALML6 MYL12B MYL9 MYL6 CALN1 MRLC3

CALM3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs143845026^1,2		--	47102591(+)	`ACGAA-/CCCC CAGCC`	2	--	us2k¹ int¹		0	--	--	--	--
rs9676749^1,2	C,F,	--	47102660(+)	`GGGATT/GGTAGT`	2	--	int¹ us2k¹		8		NA WA CSA EA	368
rs139734418^1,2		--	47102775(+)	`CAGGCA/GGATCA`	2	--	int¹ us2k¹		0	--	--	--	--
rs193154241^1,2		--	47102868(+)	`AGTGGC/TGGGTG`	2	--	us2k¹ int¹		0	--	--	--	--
rs149248204^1,2		--	47102930(+)	`GGGAGA/GCGGAG`	2	--	us2k¹ int¹		0	--	--	--	--
rs61240078^1,2		--	47102969(+)	`CACTCC/TAGCCT`	2	--	us2k¹ int¹		0	--	--	--	--
rs144425351^1,2		--	47103053(+)	`TTACCA/GTGAGG`	2	--	us2k¹ int¹		0	--	--	--	--
rs188893890^1,2		--	47103132(+)	`AACATC/TGGTGA`	2	--	us2k¹ int¹		0	--	--	--	--
rs7258489^1,2	C,F,A,H,	--	47103141(+)	`GATCAC/TATTTT`	2	--	us2k¹ int¹		18		NS EA NA WA	2336
rs148435524^1,2		--	47103187(+)	`ATTAAA/GGGCAT`	2	--	us2k¹ int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CALM3 (47104512 - 47114039 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CALM3: --
Human Gene Mutation Database (HGMD): CALM3

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CALM3

DNA2.0 Custom Variant and Variant Library Synthesis for CALM3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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CALM3 for disorders           About GeneDecksing

OMIM gene information: 114183    OMIM disorders: --

20/24 diseases for CALM3 (see all 24):    About MalaCards

senior-loken syndrome xy sex reversal sex reversal multiple epiphyseal dysplasia

hypertrophic cardiomyopathy familial hypertrophic cardiomyopathy epiphyseal dysplasia toxic encephalopathy

pseudoachondroplasia macular degeneration cardiomyopathy brain disease

cholera pertussis lung carcinoma ataxia

tuberculosis immunodeficiency carcinoma malaria

8 diseases from the University of Copenhagen DISEASES database for CALM3:

Vascular disease Cholera Cancer Pertussis

Toxic encephalopathy Otomycosis Pseudoachondroplasia Malignant hyperthermia

Human Genome Epidemiology (HuGE) Navigator: CALM3 (8 documents)

Export disorders for CALM3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CALM3 gene, integrated from 9 sources (see all 137):
(articles sorted by number of sources associating them with CALM3)

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Cep97 and CP110 suppress a cilia assembly program. (PubMed id 17719545)^{1, 2} Spektor A.... Dynlacht B.D. (2007)
CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability. (PubMed id 16760425)^{1, 2} Tsang W.Y.... Dynlacht B.D. (2006)
Insights into voltage-gated calcium channel regulation from the structure of the CaV1.2 IQ domain-Ca2+/calmodulin complex. (PubMed id 16299511)^{1, 2} Van Petegem F.... Minor D.L. Jr. (2005)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{1, 2} Rush J.... Comb M.J. (2005)
Calcium/calmodulin regulates ubiquitination of the ubiquitin-specific protease TRE17/USP6. (PubMed id 16127172)^{1, 2} Shen C....Chou M.M. (2005)
Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor. (PubMed id 15719022)^{1, 2} Shen Y.... Tang W.-J. (2005)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
Defective calmodulin-mediated nuclear transport of the sex- determining region of the Y chromosome (SRY) in XY sex reversal. (PubMed id 15746192)^{1, 2} Sim H.... Harley V.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)^{1, 2} Heilig R.... Weissenbach J. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 808	HGNC: 1449	AceView: CALM3	Ensembl:ENSG00000160014	euGenes: HUgn808
ECgene: CALM3	Kegg: 808	H-InvDB: CALM3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CALM3	Pharmacogenomics, SNPs, Pathways
Protein Spotlight	http://web.expasy.org/spotlight/back_issues/sptlt105.shtml

Intellectual Property for CALM3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CALM3 gene:
Search GeneIP for patents involving CALM3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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calmodulin 3 (phosphorylase kinase, delta)

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CALM3 Gene

calmodulin 3 (phosphorylase kinase, delta)

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