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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CALM2 Gene

protein-coding   GIFtS: 67
GCID: GC02M047272

Calmodulin 2 (Phosphorylase Kinase, Delta)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Calmodulin 2 (Phosphorylase Kinase, Delta)1 2     CALML23
Prepro-Calmodulin 21 2     CAM3
CAMII2     CAM13
PHKD2     CAM23
PHKD22     CAM33
caM2     CAMB3
calmodulin2     CAMC3
LP7057 Protein2     CAMIII3
Phosphorylase Kinase Delta2     CaM3
CALM3     

External Ids:    HGNC: 14451   Entrez Gene: 8052   Ensembl: ENSG000001439337   OMIM: 1141825   UniProtKB: P621583   

Export aliases for CALM2 gene to outside databases

Previous GC identifers: GC02M047405 GC02M047556 GC02M047361 GC02M047298 GC02M047240 GC02M047124


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CALM2 Gene: 
CALM2 (calmodulin 2 (phosphorylase kinase, delta)) is a protein-coding gene. Diseases associated with CALM2 include otomycosis, and phencyclidine abuse, and among its related super-pathways are VEGF and S-1P Signaling and Development Endothelin-1/EDNRA transactivation of EGFR. An important paralog of this gene is CALML3.

UniProtKB/Swiss-Prot: CALM_HUMAN, P62158
Function: Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+).
Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and
phosphatases. Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome
cycle and progression through cytokinesis

Gene Wiki entry for CALM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CALM2 gene promoter:
         TBP   Nkx6-1   FOXO1a   MIF-1   Pax-4a   HNF-4alpha1   FOXO1   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCALM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CALM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CALM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p21   Ensembl cytogenetic band:  2p21   HGNC cytogenetic band: 2p21.3-p21.1

CALM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALM2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M047272:  view genomic region     (about GC identifiers)

Start:
47,272,677 bp from pter      End:
47,403,740 bp from pter
Size:
131,064 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CALM_HUMAN, P62158 (See protein sequence)
Recommended Name: Calmodulin  
Size: 149 amino acids; 16838 Da
Subunit: Interacts with MYO1C and RRAD. Interacts with MYO10 (By similarity). Interacts with CEP97, CEP110,
TTN/titin and SRY. Interacts with USP6; the interaction is calcium dependent. Interacts with CDK5RAP2. Interacts
with SCN5A. Interacts with RYR1 and RYR2. Interacts with FCHO1
Subcellular location: Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed
throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and
the spindle microtubules
Miscellaneous: This protein has four functional calcium-binding sites
Sequence caution: Sequence=CAA36839.1; Type=Erroneous gene model prediction;
6/78 PDB 3D structures from and Proteopedia for CALM2 (see all 78):
1AJI (3D)        1CDL (3D)        1CLL (3D)        1CTR (3D)        1IWQ (3D)        1J7O (3D)    
Secondary accessions: P02593 P70667 P99014 Q13942 Q53S29 Q61379 Q61380 Q96HK3

Explore the universe of human proteins at neXtProt for CALM2: NX_P62158

Explore proteomics data for CALM2 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitination results in a strongly decreased activity (By similarity)
  • UniProtKB: Phosphorylation results in a decreased activity (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P62158

  • CALM2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CALM2 Protein Expression
    REFSEQ proteins: NP_001734.1  
    ENSEMBL proteins: 
     ENSP00000272298   ENSP00000406112   ENSP00000411440   ENSP00000387065  
    Reactome Protein details: P62158
    Human Recombinant Protein Products for CALM2: 
    EMD Millipore Purified and/or Recombinant CALM2 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CALM2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CALM2
    GenScript Custom Purified and Recombinant Proteins Services for CALM2
    Novus Biologicals CALM2 Proteins
    Novus Biologicals CALM2 Lysates
    Sino Biological Recombinant Protein for CALM2
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CALM2
    Cloud-Clone Corp. Proteins for CALM2 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole ----
    GO:0005576extracellular region ----
    GO:0005654nucleoplasm ----
    GO:0005737cytoplasm ----
    GO:0005813centrosome ----

    CALM2 for ontologies           About GeneDecksing



    CALM2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CALM2
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CALM2
    OriGene Custom Antibody Services for CALM2
    GenScript Custom Superior Antibodies Services for CALM2
    Novus Biologicals CALM2 Antibodies
    Abcam antibodies for CALM2
    Cloud-Clone Corp. Antibodies for CALM2 
    ThermoFisher Antibody for CALM2
    LSBio Antibodies in human, mouse, rat for CALM2 

    Assay Products for CALM2: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CALM2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CALM2 
    Cloud-Clone Corp. CLIAs for CALM2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands
    EFHAND: EF-hand domain containing

    4 InterPro protein domains:
     IPR001125 Recoverin
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry P62158

    ProtoNet protein and cluster: P62158

    UniProtKB/Swiss-Prot: CALM_HUMAN, P62158
    Similarity: Belongs to the calmodulin family
    Similarity: Contains 4 EF-hand domains


    CALM2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CALM_HUMAN, P62158
    Function: Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+).
    Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and
    phosphatases. Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome
    cycle and progression through cytokinesis

         Genatlas biochemistry entry for CALM2:
    calmodulin 2,calcium modulated protein

         Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding ----
    GO:0005515protein binding ----
    GO:0016301kinase activity ----
    GO:0019904protein domain specific binding ----
    GO:0031432titin binding ----
         
    CALM2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CALM2:
     Decreased viability 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CALM2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CALM2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CALM2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CALM2 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CALM2:
    hsa-mir-1 (MIRT005904)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALM2
    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate CALM2 (see all 59):
    hsa-miR-576-3p hsa-miR-642a hsa-miR-19b-2* hsa-miR-300 hsa-miR-765 hsa-let-7a-2* hsa-miR-301a hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidCALM2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CALM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALM2

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CALM2

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CALM2 (see all 7)
    OriGene ORF clones in mouse, rat for CALM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CALM2 (NM_001743)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALM2
    Sirion Biotech Customized lentivirus for stable overexpression of CALM2 
                         Customized lentivirus expression plasmids for stable overexpression of CALM2 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CALM2
    Search LifeMap BioReagents cell lines for CALM2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALM2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CALM2 About   (see all 83)                                                                                              See pathways by source

    SuperPathContained pathways About
    1fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    Signal transduction Activation of PKC via G-Protein coupled receptor0.42
    VEGF and S-1P Signaling0.44
    Alpha-Adrenergic Signaling0.38
    fMLP Pathway0.43
    Signal transduction Calcium signaling0.34
    2Development Endothelin-1/EDNRA signaling
    Development Endothelin-1/EDNRA signaling0.41
    GnRH signaling pathway0.38
    Development Endothelin-1/EDNRA transactivation of EGFR0.41
    Estrogen signaling pathway0.34
    Cytoskeleton remodeling FAK signaling0.41
    3Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Alzheimer's disease0.46
    Alzheimers Disease0.44
    4Signal transduction cAMP signaling
    Signal transduction cAMP signaling0.44
    G Protein Signaling Pathways0.44
    5Immune response IFN gamma signaling pathway
    Immune response IFN gamma signaling pathway0.43
    IFN-gamma pathway0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/36 EMD Millipore Pathways for CALM2 (see all 36)
        Translation Translation regulation by Alpha-1 adrenergic receptors
    Development Activation of ERK by Alpha-1 adrenergic receptors
    Immune response CD16 signaling in NK cells
    Cytoskeleton remodeling RalB regulation pathway
    Cytoskeleton remodeling FAK signaling

    5/41 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CALM2 (see all 41)
        Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods
    PI3K Signaling in B-Lymphocyte
    Dopamine-DARPP32 Feedback onto cAMP Pathway
    Alpha-Adrenergic Signaling

    5/35 GeneGo (Thomson Reuters) Pathways for CALM2 (see all 35)
        Signal transduction cAMP signaling
    Development Endothelin-1/EDNRA signaling
    Immune response CD28 signaling
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Signal transduction Activation of PKC via G-Protein coupled receptor

    5/25 BioSystems Pathways for CALM2 (see all 25)
        MicroRNAs in cardiomyocyte hypertrophy
    Myometrial Relaxation and Contraction Pathways
    G13 Signaling Pathway
    G Protein Signaling Pathways
    Glycogen Metabolism


    5/70        Reactome Pathways for CALM2 (see all 70)
        Glycogen breakdown (glycogenolysis)
    Inositol phosphate metabolism
    Visual phototransduction
    Activation of CaMK IV
    Signaling by PDGF


    5/22         Kegg Pathways  (Kegg details for CALM2) (see all 22):
        Calcium signaling pathway
    Phosphatidylinositol signaling system
    Oocyte meiosis
    Vascular smooth muscle contraction
    Circadian entrainment


    CALM2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CALM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/553 Interacting proteins for CALM2 (P621581, 2, 3 ENSP000002722984) via UniProtKB, MINT, STRING, and/or I2D (see all 553)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CACNA1CQ139361, 2, 3, ENSP000002663764EBI-397435,EBI-1038838 MINT-8087834 MINT-8087891 MINT-8087783 MINT-8087930 MINT-8087912 MINT-8087767 MINT-8087800 MINT-8087819 MINT-8087850 MINT-8087867 I2D: score=6 STRING: ENSP00000266376
    KCNH1O952591, 2, 3EBI-397435,EBI-2909270 MINT-7988123 MINT-7988100 I2D: score=3 
    FKBP8Q143182, 3MINT-58231 MINT-58233 MINT-58242 MINT-58244 I2D: score=4 
    RALAP112332, 3MINT-15766 MINT-15764 MINT-15765 I2D: score=4 
    RALBP112342, 3MINT-16957 MINT-16956 MINT-16955 I2D: score=4 
    About this table

    Gene Ontology (GO): 5/39 biological process terms (GO ID links to tree view) (see all 39):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001975response to amphetamine ----
    GO:0002027regulation of heart rate ----
    GO:0002576platelet degranulation ----
    GO:0005513detection of calcium ion ----
    GO:0005975carbohydrate metabolic process ----

    CALM2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CALM2 (CALM)

    Search CenterWatch for drugs/clinical trials and news about CALM2 / CALM

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CALM2 gene: 
    NM_001743.4  

    Unigene Cluster for CALM2:

    Calmodulin 2 (phosphorylase kinase, delta)
    Hs.468442  [show with all ESTs]
    Unigene Representative Sequence: BG110202
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000496939 ENST00000464527 ENST00000422269(uc010fbd.3) ENST00000482548
    ENST00000272298(uc002rvt.2) ENST00000460218 ENST00000432899 ENST00000482532
    ENST00000456319 ENST00000409563 ENST00000484408 ENST00000489742
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALM2
    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate CALM2 (see all 59):
    hsa-miR-576-3p hsa-miR-642a hsa-miR-19b-2* hsa-miR-300 hsa-miR-765 hsa-let-7a-2* hsa-miR-301a hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidCALM2 3' UTR sequence
    Inhib. RNA
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    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALM2
    Sirion Biotech Customized lentivirus for stable overexpression of CALM2 
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALM2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALM2

    Additional mRNA sequence: 

    AK315694.1 BC003354.1 BC006464.1 BC008437.1 BC017385.1 BC018677.1 BC026065.1 BT009916.1 
    CR541990.1 CR542021.1 D45887.1 M19311.1 

    24/86 DOTS entries (see all 86):

    DT.91881591  DT.95294800  DT.91784270  DT.100719696  DT.87017757  DT.92352590  DT.91790606  DT.100719701 
    DT.100719674  DT.87012055  DT.95319794  DT.100719692  DT.100719691  DT.91784298  DT.95230387  DT.95358900 
    DT.120954094  DT.91784266  DT.100719698  DT.100719682  DT.102842826  DT.91784191  DT.100719693  DT.100719648 

    24/3731 AceView cDNA sequences (see all 3731):

    AI631037 BQ637455 CR624584 AA679409 BG576769 BE896872 CB123864 AW770299 
    AW196702 BE779354 BQ881807 CR541990 BQ049922 AA563836 CF454214 BF968647 
    BM787591 BU162056 BU789504 BE897776 BQ880996 CD368485 BG656190 BI091374 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CALM2    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
    SP1:              -           -     -                                             
    SP2:                                -                                             
    SP3:                          -     -                                             
    SP4:                                                                              


    ECgene alternative splicing isoforms for CALM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CALM2 expression in normal human tissues (normalized intensities)      CALM2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTTGTTGA
    CALM2 Expression
    About this image


    CALM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/46 selected tissues (see all 46) fully expand
     
     Brain (Nervous System)    fully expand to see all 13 entries
             Thalamus
             brain/forebrain/telencephalon   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Lung (Respiratory System)    fully expand to see all 5 entries
             Stem Bronchi
             lung ; pneumocytes   
     
     Epithelium
             cervix, uterine ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   

    See CALM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CALM2

    SOURCE GeneReport for Unigene cluster: Hs.468442
        SABiosciences Custom PCR Arrays for CALM2
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALM2
    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CALM2 gene from 10/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Calm25 calmodulin 2   --   17 (57.49 cM) 87433412 
    chicken
    (Gallus gallus)
    Aves CALM11 calmodulin 1 (phosphorylase kinase, delta) 86.58(n)
    99.33(a)
      396523  NM_001110364.1  NP_001103834.1 
    lizard
    (Anolis carolinensis)
    Reptilia CALM16
    Uncharacterized protein
    100(a)
    1 ↔ 1
    GL343739.1(54024-70590)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC054973.12   -- 91.66(n)    BC054973.1 
    zebrafish
    (Danio rerio)
    Actinopterygii calm2d2 calmodulin 2, delta 83.75(n)   336121  BC059427.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cam1 , 3 calcium ion sensing calcium ion binding3
    Calmodulin1
    97(a)
    (best of 5)3
    77.4(n)1
    97.99(a)1
      363291  NM_078986.21  NP_523710.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cmd-11 , 3 calmodulin3
    Protein CMD-11
    97(a)
    (best of 7)3
    75.39(n)1
    97.99(a)1
      V(1156006-1157085)3
    1786141  NM_070985.41  NP_503386.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CMD1(YBR109C)4 Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin less   --   2(458362-457919) 852406  NP_009667.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CAM41 calmodulin 4 74.72(n)
    89.26(a)
      842959  NM_105312.3  NP_176814.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g04911001 hypothetical protein 71.81(n)
    90.6(a)
      4339172  NM_001062442.1  NP_001055907.1 


    ENSEMBL Gene Tree for CALM2 (if available)
    TreeFam Gene Tree for CALM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CALM2 gene
    CALM11 2  CALM31 2  CALML32  CABP52  CABP12  TNNC12  CABP42  CABP22  
    CALML62  TNNC22  CALML52  CABP72  CALML42  CALN12  
    18/71 SIMAP similar genes for CALM2 using alignment to 5 protein entries:     CALM_HUMAN (see all proteins) (see all similar genes):
    CALM1    OK/SW-cl.41    CALML3    CALM3    C9orf85    FP6651
    X-linked retinopathy protein    CLTA    LOC100996426    CALML5    CETN1    C3orf64
    TNNC2    CETN2    FP6778    SH2B3    LOC100996577    TNNC1

    CALM2 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for CALM2
    PGOHUM00000238832 PGOHUM00000248379 PGOHUM00000248475 PGOHUM00000237500 PGOHUM00000232696


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/531 SNPs in CALM2 are shown (see all 531)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1915679641,2
    --47386725(+) AAAACC/TATAAA 1 -- int10--------
    rs1509427671,2
    --47386960(+) ATGGTC/GGTGGA 1 -- int10--------
    rs1845403411,2
    --47387083(+) CCTTAC/TTTTGT 1 -- int10--------
    rs67511201,2
    H--47387097(+) TCTTAT/CTTTCT 1 -- int14Minor allele frequency- C:0.00NS EA 420
    rs170363201,2
    C,F,H--47387187(+) CCATAT/CGCTTC 1 -- int120Minor allele frequency- C:0.17NA NS EA CSA WA 2468
    rs1164214421,2
    C,F--47387253(+) TATTTT/CCAAAA 1 -- ut311Minor allele frequency- C:0.03WA 118
    rs1398123651,2
    C--47387290(+) TCAGAC/TGCAGA 1 -- ut310--------
    rs1875110421,2
    --47387326(+) TTTTAC/TTGGAA 1 -- ut310--------
    rs749591501,2
    C,F--47387346(+) ACAACT/CTGGAA 1 -- ut311Minor allele frequency- C:0.02WA 118
    rs1445392421,2
    --47387404(+) CAAAGA/TTTAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CALM2 (47272677 - 47403740 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CALM2: --

    Human Gene Mutation Database (HGMD): CALM2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CALM2
    DNA2.0 Custom Variant and Variant Library Synthesis for CALM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 114182    OMIM disorders: --

    UniProtKB/Swiss-Prot: CALM_HUMAN, P62158
  • Ventricular tachycardia, catecholaminergic polymorphic 4 (CPVT4) [MIM:614916]: An arrhythmogenic disorder
    characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest
    and cause sudden death. Patients present with recurrent syncope, seizures, or sudden death after physical
    activity or emotional stress. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • 20/22 diseases for CALM2 (see all 22):    About MalaCards
    otomycosis    phencyclidine abuse    pseudoachondroplasia    senior-loken syndrome
    malignant hyperthermia    toxic encephalopathy    scoliosis    lissencephaly
    hiv type 1    cholera    pertussis    vascular disease
    macular degeneration    osteoarthritis    ataxia    retinitis
    tuberculosis    hepatocellular carcinoma    alzheimer's disease    endotheliitis

    8 diseases from the University of Copenhagen DISEASES database for CALM2:
    Vascular disease     Cholera     Cancer     Pertussis
    Toxic encephalopathy     Otomycosis     Pseudoachondroplasia     Malignant hyperthermia

    CALM2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CALM2
    Human Genome Epidemiology (HuGE) Navigator: CALM2 (10 documents)

    Export disorders for CALM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CALM2 gene, integrated from 9 sources (see all 129):
    (articles sorted by number of sources associating them with CALM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (PubMed id 21546767)1, 4 Murea M....Freedman B.I. (2011)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    4. Identification of sequence polymorphisms in CALM2 and analysis of association with hip osteoarthritis in a Japanese population. (PubMed id 20198394)1, 4 Mototani H....Ikegawa S. (2010)
    5. Genetic variants associated with cardiac structure an d function: a meta-analysis and replication of genome-wide association data. (PubMed id 19584346)1, 4 Vasan R.S....Blankenberg S. (2009)
    6. The association of common polymorphisms in the QPCT gene with bone mineral density in the Chinese population. (PubMed id 17687619)1, 4 Huang Q.Y. and Kung A.W. (2007)
    7. Calcium/calmodulin regulates ubiquitination of the ubiquitin-specific protease TRE17/USP6. (PubMed id 16127172)1, 2 Shen C....Chou M.M. (2005)
    8. Crystal structure of a MARCKS peptide containing the calmodulin- binding domain in complex with Ca2+-calmodulin. (PubMed id 12577052)1, 2 Yamauchi E.... Taniguchi H. (2003)
    9. Characterization of the human CALM2 calmodulin gene and comparison of the transcriptional activity of CALM1, CALM2 and CALM3. (PubMed id 9681195)1, 2 Toutenhoofd S.L.... Strehler E.E. (1998)
    10. Structural organization of the human CaMIII calmodulin gene. (PubMed id 2223880)1, 2 Koller M.... Strehler E.E. (1990)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 805 HGNC: 1445 AceView: CALM2 Ensembl:ENSG00000143933 euGenes: HUgn805
    ECgene: CALM2 Kegg: 805 H-InvDB: CALM2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CALM2 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt105.shtml

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CALM2 gene:
    Search GeneIP for patents involving CALM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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