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CALM2 Gene

protein-coding   GIFtS: 66
GCID: GC02M047387

Calmodulin 2 (Phosphorylase Kinase, Delta)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calmodulin 2 (Phosphorylase Kinase, Delta)1 2     CALML23
Prepro-Calmodulin 21 2     CAM3
CAMII2     CAM13
PHKD2     CAM23
PHKD22     CAM33
caM2     CAMB3
calmodulin2     CAMC3
LP7057 Protein2     CAMIII3
Phosphorylase Kinase Delta2     CaM3
CALM3     

External Ids:    HGNC: 14451   Entrez Gene: 8052   Ensembl: ENSG000001439337   OMIM: 1141825   UniProtKB: P621583   

Export aliases for CALM2 gene to outside databases

Previous GC identifers: GC02M047405 GC02M047556 GC02M047361 GC02M047298 GC02M047240 GC02M047272 GC02M047124


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CALM2 Gene:
CALM2 (calmodulin 2 (phosphorylase kinase, delta)) is a protein-coding gene. Diseases associated with CALM2 include phencyclidine abuse, and otomycosis. An important paralog of this gene is CALML3.

UniProtKB/Swiss-Prot: CALM_HUMAN, P62158
Function: Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other
proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein
kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the
centrosome cycle and progression through cytokinesis

Gene Wiki entry for CALM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CALM2 gene promoter:
         TBP   Nkx6-1   FOXO1a   MIF-1   Pax-4a   HNF-4alpha1   FOXO1   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCALM2 promoter sequence
   Search Chromatin IP Primers for CALM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CALM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p21   Ensembl cytogenetic band:  2p21   HGNC cytogenetic band: 2p21.3-p21.1

CALM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALM2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M047387:  view genomic region     (about GC identifiers)

Start:
47,387,221 bp from pter      End:
47,403,740 bp from pter
Size:
16,520 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CALM_HUMAN, P62158 (See protein sequence)
Recommended Name: Calmodulin  
Size: 149 amino acids; 16838 Da
Subunit: Interacts with MYO1C and RRAD. Interacts with MYO10 (By similarity). Interacts with CEP97, CCP110,
TTN/titin and SRY. Interacts with USP6; the interaction is calcium dependent. Interacts with CDK5RAP2. Interacts
with SCN5A. Interacts with RYR1 and RYR2. Interacts with FCHO1. Interacts with MIP in a 1:2 stoichiometry; the
interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure
Miscellaneous: This protein has four functional calcium-binding sites
Sequence caution: Sequence=CAA36839.1; Type=Erroneous gene model prediction;
Selected PDB 3D structures from and Proteopedia for CALM2 (see all 84):
1AJI (3D)        1CDL (3D)        1CLL (3D)        1CTR (3D)        1IWQ (3D)        1J7O (3D)    
Secondary accessions: P02593 P70667 P99014 Q13942 Q53S29 Q61379 Q61380 Q96HK3

Explore the universe of human proteins at neXtProt for CALM2: NX_P62158

Explore proteomics data for CALM2 at MOPED

Post-translational modifications: 

  • Ubiquitination results in a strongly decreased activity (By similarity)1
  • Phosphorylation results in a decreased activity (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CALM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001734.1  
    ENSEMBL proteins: 
     ENSP00000272298   ENSP00000406112   ENSP00000411440   ENSP00000387065  
    Reactome Protein details: P62158

    CALM2 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CALM2 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CALM2
    OriGene Protein Over-expression Lysate for CALM2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CALM2
    GenScript Custom Purified and Recombinant Proteins Services for CALM2
    Novus Biologicals CALM2 Proteins
    Novus Biologicals CALM2 Lysates
    Sino Biological Recombinant Protein for CALM2
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CALM2
    Cloud-Clone Corp. Proteins for CALM2

    CALM2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CALM2
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CALM2
    OriGene Custom Antibody Services for CALM2
    Novus Biologicals CALM2 Antibodies
    Abcam antibodies for CALM2
    Cloud-Clone Corp. Antibodies for CALM2
    ThermoFisher Antibody for CALM2
    LSBio Antibodies in human, mouse, rat for CALM2

    CALM2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CALM2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CALM2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CALM2
    Cloud-Clone Corp. CLIAs for CALM2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    EFHAND: EF-hand domain containing

    4 InterPro protein domains:
     IPR001125 Recoverin_like
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry P62158

    ProtoNet protein and cluster: P62158

    UniProtKB/Swiss-Prot: CALM_HUMAN, P62158
    Similarity: Belongs to the calmodulin family
    Similarity: Contains 4 EF-hand domains


    CALM2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CALM_HUMAN, P62158
    Function: Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other
    proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein
    kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the
    centrosome cycle and progression through cytokinesis

         Genatlas biochemistry entry for CALM2:
    calmodulin 2,calcium modulated protein

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding ----
    GO:0005515protein binding ----
    GO:0016301kinase activity ----
    GO:0019904protein domain specific binding ----
    GO:0031432titin binding ----
         
    CALM2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CALM2:
     Decreased viability 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CALM2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CALM2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CALM2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CALM2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CALM2:
    hsa-mir-598-3p (MIRT040483), hsa-mir-1 (MIRT005904)

    Block miRNA regulation of human, mouse, rat CALM2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CALM2 (see all 59):
    hsa-miR-576-3p hsa-miR-642a hsa-miR-19b-2* hsa-miR-300 hsa-miR-765 hsa-let-7a-2* hsa-miR-301a hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidCALM2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CALM2
    Predesigned siRNA for gene silencing in human, mouse, rat CALM2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CALM2

    Clone
    Products:
         
    OriGene clones in human, mouse for CALM2 (see all 6)
    OriGene ORF clones in mouse, rat for CALM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CALM2 (NM_001743)
    Sino Biological Human cDNA Clone for CALM2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALM2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CALM2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALM2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CALM_HUMAN, P62158: Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed
    throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and
    the spindle microtubules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol4
    extracellular4
    nucleus4
    endoplasmic reticulum3
    golgi apparatus2
    mitochondrion2
    vacuole2
    chloroplast1
    endosome1
    lysosome1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole ----
    GO:0005576extracellular region ----
    GO:0005654nucleoplasm ----
    GO:0005737cytoplasm ----
    GO:0005813centrosome ----

    CALM2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CALM2 About   (see all 102)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Ca-dependent events
    DAG and IP3 signaling0.94
    PLC beta mediated events0.67
    EGFR interacts with phospholipase C-gamma0.94
    G-protein mediated events0.65
    PLC-gamma1 signalling0.94
    Phospholipase C-mediated cascade0.59
    CaM pathway0.93
    Opioid Signalling0.54
    2Post NMDA receptor activation events
    Post NMDA receptor activation events0.90
    CREB phosphorylation through the activation of CaMKII0.00
    Activation of NMDA receptor upon glutamate binding and postsynaptic events0.90
    Activation of CaMK IV0.00
    CREB phosphorylation through the activation of Ras0.78
    CaMK IV-mediated phosphorylation of CREB0.00
    Long-term potentiation0.35
    CREB phosphorylation through the activation of CaMKK0.00
    3Development Endothelin 1 EDNRA signaling
    Development Endothelin 1 EDNRA signaling0.41
    GnRH signaling pathway0.38
    Development Endothelin 1 EDNRA transactivation of EGFR0.41
    Inflammatory mediator regulation of TRP channels0.37
    Cytoskeleton remodeling FAK signaling0.41
    Estrogen signaling pathway0.34
    4fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    Signal transduction Activation of PKC via G Protein coupled receptor0.42
    VEGF and S-1P Signaling0.44
    Alpha-Adrenergic Signaling0.38
    fMLP Pathway0.43
    5ADP signalling through P2Y purinoceptor 12
    Activation of Kainate Receptors upon glutamate binding0.68
    Activation of Ca-permeable Kainate Receptor0.35
    Development Angiotensin signaling via beta Arrestin0.39
    Ionotropic activity of Kainate Receptors0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CALM2 (see all 41)
        Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods
    PI3K Signaling in B-Lymphocyte
    Dopamine-DARPP32 Feedback onto cAMP Pathway
    Alpha-Adrenergic Signaling

    Selected GeneGo (Thomson Reuters) Pathways for CALM2 (see all 35)
        Signal transduction cAMP signaling
    Development Endothelin-1/EDNRA signaling
    Immune response CD28 signaling
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Signal transduction Activation of PKC via G-Protein coupled receptor

    Selected BioSystems Pathways for CALM2 (see all 25)
        Myometrial Relaxation and Contraction Pathways
    MicroRNAs in cardiomyocyte hypertrophy
    G13 Signaling Pathway
    G Protein Signaling Pathways
    Glycogen Metabolism


    Selected Reactome Pathways for CALM2 (see all 22)
        Glycogen breakdown (glycogenolysis)
    Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
    Inactivation, recovery and regulation of the phototransduction cascade
    DARPP-32 events
    Activation of CaMK IV


    Selected Kegg Pathways  (Kegg details for CALM2) (see all 27):
        Ras signaling pathway
    Rap1 signaling pathway
    Calcium signaling pathway
    Phosphatidylinositol signaling system
    Oocyte meiosis


    CALM2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CALM2
    Interactions:

        Search GeneGlobe Interaction Network for CALM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CALM2 (P621581, 2, 3 ENSP000002722984) via UniProtKB, MINT, STRING, and/or I2D (see all 642)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CACNA1CQ139361, 2, 3, ENSP000002663764EBI-397435,EBI-1038838 MINT-8087834 MINT-8087891 MINT-8087783 MINT-8087930 MINT-8087912 MINT-8087767 MINT-8087800 MINT-8087819 MINT-8087850 MINT-8087867 I2D: score=6 STRING: ENSP00000266376
    KCNH1O952591, 2, 3EBI-397435,EBI-2909270 MINT-7988123 MINT-7988100 I2D: score=3 
    MYO10Q9HD671, 2, 3EBI-397435,EBI-307061 MINT-6595938 MINT-6596013 I2D: score=3 
    RCHY1Q96PM51, 2, 3EBI-397435,EBI-947779 MINT-5114562 MINT-5114545 I2D: score=2 
    YWHAZP631041, 2, 3EBI-397435,EBI-347088 MINT-7899812 MINT-3295975 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 39):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001975response to amphetamine ----
    GO:0002027regulation of heart rate ----
    GO:0002576platelet degranulation ----
    GO:0005513detection of calcium ion ----
    GO:0005975carbohydrate metabolic process ----

    CALM2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CALM2 (CALM)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CALM2 gene: 
    NM_001743.4  

    Unigene Cluster for CALM2:

    Calmodulin 2 (phosphorylase kinase, delta)
    Hs.468442  [show with all ESTs]
    Unigene Representative Sequence: BG110202
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000272298(uc002rvt.2) ENST00000460218 ENST00000432899 ENST00000482532
    ENST00000456319 ENST00000409563 ENST00000484408 ENST00000489742
    miRNA
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    Block miRNA regulation of human, mouse, rat CALM2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CALM2 (see all 59):
    hsa-miR-576-3p hsa-miR-642a hsa-miR-19b-2* hsa-miR-300 hsa-miR-765 hsa-let-7a-2* hsa-miR-301a hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidCALM2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CALM2
    Predesigned siRNA for gene silencing in human, mouse, rat CALM2
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CALM2 (NM_001743)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALM2
    Primer
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    OriGene qPCR primer pairs and template standards for CALM2
    OriGene qSTAR qPCR primer pairs in human, mouse for CALM2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CALM2
      QuantiTect SYBR Green Assays in human, mouse, rat CALM2
      QuantiFast Probe-based Assays in human, mouse, rat CALM2

    Additional mRNA sequence: 

    AK315694.1 BC003354.1 BC006464.1 BC008437.1 BC017385.1 BC018677.1 BC026065.1 BT009916.1 
    CR541990.1 CR542021.1 D45887.1 M19311.1 

    Selected DOTS entries (see all 86):

    DT.91881591  DT.95294800  DT.91784270  DT.100719696  DT.87017757  DT.92352590  DT.91790606  DT.100719701 
    DT.100719674  DT.87012055  DT.95319794  DT.100719692  DT.100719691  DT.91784298  DT.95230387  DT.95358900 
    DT.120954094  DT.91784266  DT.100719698  DT.100719682  DT.102842826  DT.91784191  DT.100719693  DT.100719648 

    Selected AceView cDNA sequences (see all 3731):

    AA494360 BQ933629 CR605737 BG575946 BM770662 BG656503 BU183936 CB141431 
    BQ216349 BG576769 BF058156 CR607251 T16437 AL533404 BE269074 AA346016 
    BM829529 BP340714 BI091774 BF475667 AV714980 CB156488 BM742475 BQ428201 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CALM2    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
    SP1:              -           -     -                                             
    SP2:                                -                                             
    SP3:                          -     -                                             
    SP4:                                                                              


    ECgene alternative splicing isoforms for CALM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CALM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTTGTTGA
    CALM2 Expression
    About this image


    CALM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 24) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Primary Oocyte Primary Follicle
             Oviduct
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Secondary Spermatocyte Seminiferous Tubules
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
    CALM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CALM2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.468442
        Custom PCR Arrays for CALM2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CALM2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CALM2
    QuantiTect SYBR Green Assays in human, mouse, rat CALM2
    QuantiFast Probe-based Assays in human, mouse, rat CALM2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CALM2 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Calm25 calmodulin 2   --   17 (57.49 cM) 87433412 
    chicken
    (Gallus gallus)
    Aves CALM11 calmodulin 1 (phosphorylase kinase, delta) 86.58(n)
    99.33(a)
      396523  NM_001110364.1  NP_001103834.1 
    lizard
    (Anolis carolinensis)
    Reptilia CALM26
    calmodulin 2 (phosphorylase kinase, delta)
    100(a)
    1 ↔ 1
    2(143449986-143470806)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC054973.12   -- 91.66(n)    BC054973.1 
    zebrafish
    (Danio rerio)
    Actinopterygii calm2d2 calmodulin 2, delta 83.75(n)   336121  BC059427.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cam3 calcium ion sensing calcium ion binding 97(a)
    (best of 5)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea cmd-13 calmodulin 97(a)
    (best of 7)
      V(1156006-1157085)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CAM71 CAM7 75.39(n)
    89.93(a)
      823492  NM_114249.3  NP_189967.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g06872001 Os07g0687200 75.17(n)
    90.6(a)
      4344344  NM_001067226.1  NP_001060691.1 


    ENSEMBL Gene Tree for CALM2 (if available)
    TreeFam Gene Tree for CALM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CALM2 gene
    CALM11 2  CALM31 2  CALML32  CABP52  CABP12  TNNC12  CABP42  CABP22  
    CALML62  TNNC22  CALML52  CALML42  
    Selected SIMAP similar genes for CALM2 using alignment to 5 protein entries:     CALM_HUMAN (see all proteins) (see all similar genes):
    CALM1    OK/SW-cl.41    CALML3    CALM3    C9orf85    FP6651
    X-linked retinopathy protein    CLTA    CALML5    CETN1    C3orf64    TNNC2
    CETN2    FP6778    SH2B3    TNNC1    GPD2    HC6

    CALM2 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for CALM2
    PGOHUM00000238832 PGOHUM00000248379 PGOHUM00000248475 PGOHUM00000237500 PGOHUM00000232696


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CALM2 (see all 531)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1915679641,2
    --47386725(+) AAAACC/TATAAA 1 -- int10--------
    rs1509427671,2
    --47386960(+) ATGGTC/GGTGGA 1 -- int10--------
    rs1845403411,2
    --47387083(+) CCTTAC/TTTTGT 1 -- int10--------
    rs67511201,2
    H--47387097(+) TCTTAT/CTTTCT 1 -- int14Minor allele frequency- C:0.00NS EA 420
    rs170363201,2
    C,F,H--47387187(+) CCATAT/CGCTTC 1 -- int120Minor allele frequency- C:0.17NA NS EA CSA WA 2468
    rs1164214421,2
    C,F--47387253(+) TATTTT/CCAAAA 1 -- ut311Minor allele frequency- C:0.03WA 118
    rs1398123651,2
    C--47387290(+) TCAGAC/TGCAGA 1 -- ut310--------
    rs1875110421,2
    --47387326(+) TTTTAC/TTGGAA 1 -- ut310--------
    rs749591501,2
    C,F--47387346(+) ACAACT/CTGGAA 1 -- ut311Minor allele frequency- C:0.02WA 118
    rs1445392421,2
    --47387404(+) CAAAGA/TTTAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CALM2 (47387221 - 47403740 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CALM2: --
    Human Gene Mutation Database (HGMD): CALM2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CALM2
    DNA2.0 Custom Variant and Variant Library Synthesis for CALM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 114182    OMIM disorders: --

    UniProtKB/Swiss-Prot: CALM_HUMAN, P62158
  • Ventricular tachycardia, catecholaminergic polymorphic, 4 (CPVT4) [MIM:614916]: An arrhythmogenic
    disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac
    arrest and cause sudden death. Patients present with recurrent syncope, seizures, or sudden death after physical
    activity or emotional stress. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • Selected diseases for CALM2 (see all 29):    
    About MalaCards
    phencyclidine abuse    otomycosis    pseudoachondroplasia    senior-loken syndrome
    malignant hyperthermia    toxic encephalopathy    lissencephaly    pertussis
    vascular disease    cholera    labyrinthitis    osteoarthritis
    ataxia    hiv-1    tuberculosis    retinitis
    tonsillitis    alzheimer's disease    obesity    hepatocellular carcinoma

    8 diseases from the University of Copenhagen DISEASES database for CALM2:
    Vascular disease     Cholera     Cancer     Pertussis
    Toxic encephalopathy     Otomycosis     Pseudoachondroplasia     Malignant hyperthermia

    CALM2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CALM2
    Human Genome Epidemiology (HuGE) Navigator: CALM2 (10 documents)

    Export disorders for CALM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CALM2 gene, integrated from 10 sources (see all 132):
    (articles sorted by number of sources associating them with CALM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (PubMed id 21546767)1, 4 Murea M....Freedman B.I. (Am. J. Nephrol. 2011)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Identification of sequence polymorphisms in CALM2 and analysis of association with hip osteoarthritis in a Japanese population. (PubMed id 20198394)1, 4 Mototani H....Ikegawa S. (J. Bone Miner. Metab. 2010)
    5. Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. (PubMed id 19584346)1, 4 Vasan R.S....Blankenberg S. (JAMA 2009)
    6. The association of common polymorphisms in the QPCT gene with bone mineral density in the Chinese population. (PubMed id 17687619)1, 4 Huang Q.Y. and Kung A.W. (J. Hum. Genet. 2007)
    7. Calcium/calmodulin regulates ubiquitination of the ubiquitin-specific protease TRE17/USP6. (PubMed id 16127172)1, 2 Shen C.... Chou M.M. (J. Biol. Chem. 2005)
    8. Crystal structure of a MARCKS peptide containing the calmodulin- binding domain in complex with Ca2+-calmodulin. (PubMed id 12577052)1, 2 Yamauchi E.... Taniguchi H. (Nat. Struct. Biol. 2003)
    9. Characterization of the human CALM2 calmodulin gene and comparison of the transcriptional activity of CALM1, CALM2 and CALM3. (PubMed id 9681195)1, 2 Toutenhoofd S.L.... Strehler E.E. (Cell Calcium 1998)
    10. Structural organization of the human CaMIII calmodulin gene. (PubMed id 2223880)1, 2 Koller M.... Strehler E.E. (Biochim. Biophys. Acta 1990)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 805 HGNC: 1445 AceView: CALM2 Ensembl:ENSG00000143933 euGenes: HUgn805
    ECgene: CALM2 Kegg: 805 H-InvDB: CALM2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CALM2 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/105

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CALM2 gene:
    Search GeneIP for patents involving CALM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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