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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CALM2 Gene

protein-coding GIFtS: 66
GCID: GC02M047272

calmodulin 2 (phosphorylase kinase, delta)

Explore 18 diseases affiliated with
CALM2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Calmodulin 2 (Phosphorylase Kinase, Delta)¹ ²		CALML2³
CAMII¹ ²		CAM³
PHKD¹ ²		CAM1³
PHKD2²		CAM2³
CaM³		CAM3³
Calmodulin¹		CAMB³
LP7057 Protein²		CAMC³
Phosphorylase Kinase Delta²		CAMIII³
Prepro-Calmodulin 2²		CaM³
CALM³

External Ids:	HGNC: 1445¹	Entrez Gene: 805²	Ensembl: ENSG00000143933⁷	OMIM: 114182⁵	UniProtKB: P62158³

Export aliases for CALM2 gene to outside databases

Previous GC identifers: GC02M047405 GC02M047556 GC02M047361 GC02M047298 GC02M047240 GC02M047124

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CALM_HUMAN, P62158

Function: Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+).

Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.

Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression

through cytokinesis

Gene Wiki entry for CALM2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CALM2 gene promoter:
TBP Nkx6-1 FOXO1a MIF-1 Pax-4a HNF-4alpha1 FOXO1 FOXL1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CALM2 promoter sequence

Search SABiosciences Chromatin IP Primers for CALM2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CALM2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p21 Ensembl cytogenetic band: 2p21 HGNC cytogenetic band: 2p21.3-p21.1

CALM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALM2 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M047272: view genomic region (about GC identifiers)

Start:	47,272,677 bp from pter	End:	47,403,740 bp from pter
Size:	131,064 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CALM_HUMAN, P62158 (See protein sequence)

Recommended Name: Calmodulin

Size: 149 amino acids; 16838 Da

Subunit: Interacts with MYO1C and RRAD. Interacts with MYO10 (By similarity). Interacts with CEP97, CEP110, TTN/titin

and SRY. Interacts with USP6; the interaction is calcium dependent. Interacts with CDK5RAP2. Interacts with SCN5A.

Interacts with RYR1 and RYR2. Interacts with FCHO1

Subcellular location: Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed

throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the

spindle microtubules

Miscellaneous: This protein has four functional calcium-binding sites

Sequence caution: Sequence=CAA36839.1; Type=Erroneous gene model prediction;

6/76 PDB 3D structures from and Proteopedia for CALM2 (see all 76):

1AJI (3D)

1CDL (3D)

1CLL (3D)

1CTR (3D)

1IWQ (3D)

1J7O (3D)

Secondary accessions: P02593 P70667 P99014 Q13942 Q53S29 Q61379 Q61380 Q96HK3

Explore the universe of human proteins at neXtProt for CALM2: NX_P62158

Post-translational modifications:

Ubiquitination results in a strongly decreased activity (By similarity)¹

Phosphorylation results in a decreased activity (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P62158

CALM2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001734.1

ENSEMBL proteins:

ENSP00000272298 ENSP00000406112 ENSP00000411440 ENSP00000387065

Reactome Protein details: P62158
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant CALM2 Protein
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: CALM2 OriGene Custom Protein Services for CALM2
	GenScript Custom Purified and Recombinant Proteins Services for CALM2
	Novus Biologicals CALM2 Proteins Novus Biologicals CALM2 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CALM2
	Uscn Proteins for CALM2

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000922	spindle pole	--	--
GO:0005576	extracellular region	--	--
GO:0005654	nucleoplasm	--	--
GO:0005737	cytoplasm	--	--
GO:0005813	centrosome	--	--

CALM2 for ontologies About GeneDecksing

CALM2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CALM2
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 2): CALM2 OriGene Custom Antibody Services for CALM2
	GenScript Custom Superior Antibodies Services for CALM2
	Novus Biologicals CALM2 Antibodies
	Abcam antibodies for CALM2
	Uscn Antibodies for CALM2
	ThermoFisher Antibody for CALM2

Assay Products for CALM2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CALM2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CALM2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CALM2 for domains About GeneDecksing

4 InterPro domains/families:

IPR001125 Recoverin

IPR011992 EF-hand-like_dom

IPR002048 EF_hand_Ca-bd

IPR018247 EF_Hand_1_Ca_BS

Graphical View of Domain Structure for InterPro Entry P62158

ProtoNet protein and cluster: P62158

UniProtKB/Swiss-Prot: CALM_HUMAN, P62158

Similarity: Belongs to the calmodulin family

Similarity: Contains 4 EF-hand domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CALM_HUMAN, P62158

Function: Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+).

Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.

Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression

through cytokinesis

Genatlas biochemistry entry for CALM2:

calmodulin 2,calcium modulated protein

miRNA Products:		miRTarBase miRNAs that target CALM2: hsa-mir-1 (MIRT005904)

		OriGene 3'-UTR Clone: CALM2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALM2
		8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate CALM2 (see all 59):
		hsa-miR-576-3p hsa-miR-642a hsa-miR-19b-2* hsa-miR-300 hsa-miR-765 hsa-let-7a-2* hsa-miR-301a hsa-miR-507

		SwitchGear 3'UTR luciferase reporter plasmid: CALM2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CALM2 (see all 7) OriGene shRNA RFP: CALM2 OriGene siRNA: CALM2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALM2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CALM2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CALM2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CALM2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CALM2 (NM_001743)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALM2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALM2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CALM2
		Search LifeMap BioReagents cell lines for CALM2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALM2

Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	--	--
GO:0005515	protein binding	--	--
GO:0016301	kinase activity	--	--
GO:0019904	protein domain specific binding	--	--
GO:0031432	titin binding	--	--

CALM2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CALM2:

Decreased viability

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/86 super-pathways (see all 86) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Development Angiotensin activation of ERK

Development Angiotensin activation of ERK	1.00	Development ACM2 and ACM4 activation of ERK	0.74
Development_Angiotensin activation of ERK	0.98	Development_G-Proteins mediated regulation MARK-ERK signaling	0.66
Development_ACM2 and ACM4 activation of ERK	0.74	Development G-Proteins mediated regulation MARK-ERK signaling	0.66

Development_Endothelin-1/EDNRA transactivation of EGFR

Development_Endothelin-1/EDNRA transactivation of EGFR	1.00	Development_Endothelin-1/EDNRA signaling	0.41
Development Endothelin-1/EDNRA transactivation of EGFR	1.00	Cytoskeleton remodeling_FAK signaling	0.41
Development Endothelin-1/EDNRA signaling	0.41	Cytoskeleton remodeling FAK signaling	0.41

Translation_Translation regulation by Alpha-1 adrenergic receptors

	Translation_Translation regulation by Alpha-1 adrenergic receptors	1.00			Development_Activation of ERK by Alpha-1 adrenergic receptors	0.64
	Translation Translation regulation by Alpha-1 adrenergic receptors	1.00			Development Activation of ERK by Alpha-1 adrenergic receptors	0.64

Cytoskeleton remodeling_RalB regulation pathway

	Cytoskeleton remodeling RalB regulation pathway	1.00			Cytoskeleton remodeling_RalA regulation pathway	0.23
	Cytoskeleton remodeling_RalB regulation pathway	1.00			Cytoskeleton remodeling RalA regulation pathway	0.23

Sweet Taste Signaling

	Sweet Taste Signaling	1.00			Cellular Effects of Sildenafil	0.46
	Melatonin Signaling	0.72			Sperm Motility	0.36

Pathway sources
See GeneCards unified pathways
Show all pathways

5/36 EMD Millipore Pathways for CALM2 (see all 36)

	Translation Translation regulation by Alpha-1 adrenergic receptors
	Development Activation of ERK by Alpha-1 adrenergic receptors
	Immune response CD16 signaling in NK cells
	Cytoskeleton remodeling RalB regulation pathway
	Cytoskeleton remodeling FAK signaling

5/41 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CALM2 (see all 41)

	Intracellular Calcium Signaling
	Visual Cycle in Retinal Rods
	PI3K Signaling in B-Lymphocyte
	Dopamine-DARPP32 Feedback onto cAMP Pathway
	Alpha-Adrenergic Signaling

5/35 GeneGo (Thomson Reuters) Pathways for CALM2 (see all 35)

	Signal transduction cAMP signaling
	Development Endothelin-1/EDNRA signaling
	Immune response CD28 signaling
	Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
	Signal transduction Activation of PKC via G-Protein coupled receptor

5/25 BioSystems Pathways for CALM2 (see all 25)

	Myometrial Relaxation and Contraction Pathways
	G Protein Signaling Pathways
	MicroRNAs in cardiomyocyte hypertrophy
	G13 Signaling Pathway
	Calcium Regulation in the Cardiac Cell

5/66 Reactome Pathways for CALM2 (see all 66)

	Glycogen breakdown (glycogenolysis)
	Inositol phosphate metabolism
	Activation of CaMK IV
	Signaling by PDGF
	Activation of NMDA receptor upon glutamate binding and postsynaptic events

5/17 Kegg Pathways (Kegg details for CALM2) (see all 17):

	Calcium signaling pathway
	Phosphatidylinositol signaling system
	Oocyte meiosis
	Vascular smooth muscle contraction
	Long-term potentiation

CALM2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CALM2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/547 Interacting proteins for CALM2 (P62158^{1, 2, 3} ENSP00000272298⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 547)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CACNA1C	Q13936¹^,²^,³, ENSP00000266376⁴	EBI-397435,EBI-1038838 MINT-8087834 MINT-8087891 MINT-8087783 MINT-8087930 MINT-8087912 MINT-8087767 MINT-8087800 MINT-8087819 MINT-8087850 MINT-8087867 I2D: score=6 STRING: ENSP00000266376
KCNH1	O95259¹^,²^,³	EBI-397435,EBI-2909270 MINT-7988123 MINT-7988100 I2D: score=3
FKBP8	Q14318²^,³	MINT-58231 MINT-58233 MINT-58242 MINT-58244 I2D: score=4
RALA	P11233²^,³	MINT-15766 MINT-15764 MINT-15765 I2D: score=4
RALB	P11234²^,³	MINT-16957 MINT-16956 MINT-16955 I2D: score=4

About this table

Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002576	platelet degranulation	--	--
GO:0005975	carbohydrate metabolic process	--	--
GO:0005980	glycogen catabolic process	--	--
GO:0006006	glucose metabolic process	--	--
GO:0006936	muscle contraction	--	--

CALM2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CALM2
Search CenterWatch for drugs/clinical trials and news about CALM2 / CALM

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CALM2 gene:

NM_001743.4

Unigene Cluster for CALM2:

Calmodulin 2 (phosphorylase kinase, delta)

Hs.468442 [show with all ESTs]

Unigene Representative Sequence: BG110202

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000496939 ENST00000464527 ENST00000422269(uc010fbd.3) ENST00000482548

ENST00000272298(uc002rvt.2) ENST00000460218 ENST00000432899 ENST00000482532

ENST00000456319 ENST00000409563 ENST00000484408 ENST00000489742

miRNA Products:		OriGene 3'-UTR Clone: CALM2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALM2
		8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate CALM2 (see all 59):
		hsa-miR-576-3p hsa-miR-642a hsa-miR-19b-2* hsa-miR-300 hsa-miR-765 hsa-let-7a-2* hsa-miR-301a hsa-miR-507

		SwitchGear 3'UTR luciferase reporter plasmid: CALM2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CALM2 (see all 7) OriGene shRNA RFP: CALM2 OriGene siRNA: CALM2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALM2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CALM2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CALM2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CALM2 (NM_001743)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALM2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALM2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CALM2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CALM2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALM2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALM2

Additional cDNA sequence:

AK315694.1 BC003354.1 BC006464.1 BC008437.1 BC017385.1 BC018677.1 BC026065.1 BT009916.1

CR541990.1 CR542021.1 D45887.1 M19311.1

24/85 DOTS entries (see all 85):

DT.91881591 DT.95294800 DT.91784270 DT.100719696 DT.92352590 DT.87017757 DT.91790606 DT.100719701

DT.100719674 DT.87012055 DT.95319794 DT.100719692 DT.91784298 DT.95230387 DT.95358900 DT.100719691

DT.120954094 DT.91784266 DT.100719698 DT.102842826 DT.91784191 DT.100719693 DT.100719682 DT.100719676

24/3731 AceView cDNA sequences (see all 3731):

CR541990 BC003354 BM831954 AA063058 BG387896 CB141431 AW163041 CB112243

CR605737 AW023319 AW629575 AI423804 BQ712378 AW196878 BP382975 CB161931

AI858373 AW190729 BF058156 CR605016 BP369728 CB135535 BQ224095 AW517235

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CALM2 About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5a	·	5b	^	6	^	7	^	8a	·	8b	·	8c	·	8d
SP1:					-				-		-
SP2:											-
SP3:									-		-
SP4:

ECgene alternative splicing isoforms for CALM2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CALM2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGTTGTTGA

About this image

CALM2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Primary Follicle

Primary Oocyte

Female Gametocytes, Germ Cells

Testis

Seminiferous Tubules

Secondary Spermatocyte

Germ Cells, Male Gametocytes

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CALM2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CALM2

SOURCE GeneReport for Unigene cluster: Hs.468442

SABiosciences Custom PCR Arrays for CALM2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CALM2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CALM2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALM2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALM2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALM2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CALM2 gene from 8/31 species (see all 31) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CALM1¹	calmodulin 1 (phosphorylase kinase, delta)	86.58(n) 99.33(a)		396523 NM_001110364.1 NP_001103834.1
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	--	99(a) 67(a) (see all 3)	possible ortholog possible ortholog (see all 3)	GL343568.1(347088-358586) GL343728.1(65478-65930)
African clawed frog (Xenopus laevis)	Amphibia	BC054973.1²	--	91.66(n)		BC054973.1
zebrafish (Danio rerio)	Actinopterygii	calm2d²	calmodulin 2, delta	83.75(n)		336121 BC059427.1
fruit fly (Drosophila melanogaster)	Insecta	Cam^{1 , 3}	calcium ion sensing calcium ion binding³ Calmodulin¹	97(a) (best of 5)³ 77.4(n)¹ 97.99(a)¹		36329¹ NM_078986.2¹ NP_523710.1¹
worm (Caenorhabditis elegans)	Secernentea	cmd-1^{1 , 3}	calmodulin³ Protein CMD-1¹	97(a) (best of 7)³ 75.39(n)¹ 97.99(a)¹		V(1156006-1157085)³ 178614¹ NM_070985.4¹ NP_503386.1¹
thale cress (Arabidopsis thaliana)	eudicotyledons	CAM4¹	calmodulin 4	74.72(n) 89.26(a)		842959 NM_105312.3 NP_176814.1
rice (Oryza sativa)	Liliopsida	Os05g0491100¹	hypothetical protein	71.81(n) 90.6(a)		4339172 NM_001062442.1 NP_001055907.1

ENSEMBL Gene Tree for CALM2 (if available)
TreeFam Gene Tree for CALM2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CALM2 gene

CALM1¹ ² CALM3¹ ² CALML3² CABP5² CABP1² TNNC1² CABP4² CABP2²

TNNC2² CALML6² CALML5² CALML4² CABP7² CALN1²

18/61 SIMAP similar genes for CALM2 using alignment to 4 protein entries: CALM_HUMAN (see all proteins) (see all similar genes):

CALM1 CALM3 OK/SW-cl.41 CALML3 C9orf85 FP6651

X-linked retinopathy protein CLTA CALML5 CETN1 C3orf64 TNNC2

CETN2 FP6778 SH2B3 TNNC1 HC6 LOC100996300

CALM2 for paralogs About GeneDecksing

5 Pseudogenes.org Pseudogenes for CALM2
PGOHUM00000238832 PGOHUM00000248379 PGOHUM00000248475 PGOHUM00000237500 PGOHUM00000232696

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs191567964^1,2		--	47386725(+)	`AAAACC/TATAAA`	1	--	int¹		0	--	--	--	--
rs150942767^1,2		--	47386960(+)	`ATGGTC/GGTGGA`	1	--	int¹		0	--	--	--	--
rs184540341^1,2		--	47387083(+)	`CCTTAC/TTTTGT`	1	--	int¹		0	--	--	--	--
rs6751120^1,2	H	--	47387097(+)	`TCTTAT/CTTTCT`	1	--	int¹		4		NS EA	420
rs17036320^1,2	C,F,H,	--	47387187(+)	`CCATAT/CGCTTC`	1	--	int¹		20		NA NS EA CSA WA	2468
rs116421442^1,2	F,	--	47387253(+)	`TATTTT/CCAAAA`	1	--	ut3¹		1		WA	118
rs139812365^1,2		--	47387290(+)	`TCAGAC/TGCAGA`	1	--	ut3¹		0	--	--	--	--
rs187511042^1,2		--	47387326(+)	`TTTTAC/TTGGAA`	1	--	ut3¹		0	--	--	--	--
rs74959150^1,2	F,	--	47387346(+)	`ACAACT/CTGGAA`	1	--	ut3¹		1		WA	118
rs144539242^1,2		--	47387404(+)	`CAAAGA/TTTAAA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CALM2 (47272677 - 47403740 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CALM2: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CALM2

DNA2.0 Custom Variant and Variant Library Synthesis for CALM2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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CALM2 for disorders           About GeneDecksing

OMIM gene information: 114182    OMIM disorders: --

18 diseases for CALM2:    About MalaCards

senior-loken syndrome xy sex reversal sex reversal phencyclidine abuse

macular degeneration scoliosis pertussis hepatocellular carcinoma

osteoarthritis ataxia tuberculosis immunodeficiency

carcinoma malaria neuronitis hiv type 1

breast cancer retinitis

8 diseases from the University of Copenhagen DISEASES database for CALM2:

Vascular disease Cholera Cancer Pertussis

Toxic encephalopathy Otomycosis Pseudoachondroplasia Malignant hyperthermia

Human Genome Epidemiology (HuGE) Navigator: CALM2 (10 documents)

Export disorders for CALM2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CALM2 gene, integrated from 9 sources (see all 114):
(articles sorted by number of sources associating them with CALM2)

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Calcium/calmodulin regulates ubiquitination of the ubiquitin-specific protease TRE17/USP6. (PubMed id 16127172)^{1, 2} Shen C....Chou M.M. (2005)
Crystal structure of a MARCKS peptide containing the calmodulin- binding domain in complex with Ca2+-calmodulin. (PubMed id 12577052)^{1, 2} Yamauchi E.... Taniguchi H. (2003)
Characterization of the human CALM2 calmodulin gene and comparison of the transcriptional activity of CALM1, CALM2 and CALM3. (PubMed id 9681195)^{1, 2} Toutenhoofd S.L.... Strehler E.E. (1998)
Structural organization of the human CaMIII calmodulin gene. (PubMed id 2223880)^{1, 2} Koller M.... Strehler E.E. (1990)
Molecular analysis of human and rat calmodulin complementary DNA clones. Evidence for additional active genes in these species. (PubMed id 2445749)^{1, 2} Sengupta B.... Detera-Wadleigh S.D. (1987)
Cell type-specific regulation of calmodulin 2 expression by mutant p53. (PubMed id 15225611)^{1, 9} Knaup K.X. and Roemer K. (2004)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Crystallographic basis for calcium regulation of sodiu m channels. (PubMed id 22331908)¹ Sarhan M.F....Ahern C.A. (2012)
F-box protein FBXL2 targets cyclin D2 for ubiquitinati on and degradation to inhibit leukemic cell proliferation. (PubMed id 22323446)¹ Chen B.B....Mallampalli R.K. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 805	HGNC: 1445	AceView: CALM2	Ensembl:ENSG00000143933	euGenes: HUgn805
ECgene: CALM2	Kegg: 805	H-InvDB: CALM2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CALM2	Pharmacogenomics, SNPs, Pathways
Protein Spotlight	http://web.expasy.org/spotlight/back_issues/sptlt105.shtml

Intellectual Property for CALM2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CALM2 gene:
Search GeneIP for patents involving CALM2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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calmodulin 2 (phosphorylase kinase, delta)

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CALM2 (Gene Symbol)
Calmodulin 2 (Phosphorylase Kinase, Delta)
CAMII
PHKD
PHKD2
CaM
Calmodulin
LP7057 Protein
Phosphorylase Kinase Delta
Prepro-Calmodulin 2
CALM
CALML2
CAM
CAM1
CAM2
CAM3
CAMB
CAMC
CAMIII
CaM

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CALM2 Gene

calmodulin 2 (phosphorylase kinase, delta)

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