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Aliases for CALM1 Gene

Aliases for CALM1 Gene

  • Calmodulin 1 (Phosphorylase Kinase, Delta) 2 3
  • Prepro-Calmodulin 1 2 3
  • CALML2 3 4
  • CAM 3 4
  • Phosphorylase Kinase, Delta Subunit 3
  • CALM1 CALM2 CALM3 4
  • CAMIII 4
  • CPVT4 3
  • DD132 3
  • LQT14 3
  • PHKD 3
  • CALM 4
  • CAM1 4
  • CAM2 4
  • CAM3 4
  • CAMB 4
  • CAMC 4
  • CAMI 3

External Ids for CALM1 Gene

Previous HGNC Symbols for CALM1 Gene

  • CALML2

Previous GeneCards Identifiers for CALM1 Gene

  • GC14P088369
  • GC14P084679
  • GC14P088853
  • GC14P089933
  • GC14P090863
  • GC14P071038

Summaries for CALM1 Gene

Entrez Gene Summary for CALM1 Gene

  • This gene encodes a member of the EF-hand calcium-binding protein family. It is one of three genes which encode an identical calcium binding protein which is one of the four subunits of phosphorylase kinase. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

GeneCards Summary for CALM1 Gene

CALM1 (Calmodulin 1 (Phosphorylase Kinase, Delta)) is a Protein Coding gene. Diseases associated with CALM1 include calm1-related catecholaminergic polymorphic ventricular tachycardia and ventricular tachycardia, catecholaminergic polymorphic, 4. Among its related pathways are Immune System and DAG and IP3 signaling. GO annotations related to this gene include calcium ion binding and protein domain specific binding. An important paralog of this gene is CABP2.

UniProtKB/Swiss-Prot for CALM1 Gene

  • Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.

Gene Wiki entry for CALM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALM1 Gene

Genomics for CALM1 Gene

Regulatory Elements for CALM1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CALM1 Gene

Chromosome:
14
Start:
90,396,502 bp from pter
End:
90,408,275 bp from pter
Size:
11,774 bases
Orientation:
Plus strand

Genomic View for CALM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CALM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALM1 Gene

Proteins for CALM1 Gene

  • Protein details for CALM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62158-CALM_HUMAN
    Recommended name:
    Calmodulin
    Protein Accession:
    P62158
    Secondary Accessions:
    • P02593
    • P70667
    • P99014
    • Q13942
    • Q53S29
    • Q61379
    • Q61380
    • Q96HK3

    Protein attributes for CALM1 Gene

    Size:
    149 amino acids
    Molecular mass:
    16838 Da
    Quaternary structure:
    • Interacts with MYO1C, MYO5A and RRAD. Interacts with MYO10 (By similarity). Interacts with CEP97, CCP110, TTN/titin and SRY. Interacts with USP6; the interaction is calcium dependent. Interacts with CDK5RAP2. Interacts with SCN5A. Interacts with RYR1 and RYR2. Interacts with FCHO1. Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure. Interacts with ORAI1; this may play a role in the regulation of ORAI1-mediated calcium transport.
    • Interacts with MYO1C, MYO5A and RRAD. Interacts with MYO10 (By similarity). Interacts with CEP97, CCP110, TTN/titin and SRY. Interacts with USP6; the interaction is calcium dependent. Interacts with CDK5RAP2. Interacts with SCN5A. Interacts with RYR1 and RYR2. Interacts with FCHO1. Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure. Interacts with ORAI1; this may play a role in the regulation of ORAI1-mediated calcium transport.
    • Interacts with MYO1C, MYO5A and RRAD. Interacts with MYO10 (By similarity). Interacts with CEP97, CCP110, TTN/titin and SRY. Interacts with USP6; the interaction is calcium dependent. Interacts with CDK5RAP2. Interacts with SCN5A. Interacts with RYR1 and RYR2. Interacts with FCHO1. Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure. Interacts with ORAI1; this may play a role in the regulation of ORAI1-mediated calcium transport.
    Miscellaneous:
    • This protein has four functional calcium-binding sites
    SequenceCaution:
    • Sequence=CAA36839.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CALM1 Gene

neXtProt entry for CALM1 Gene

Proteomics data for CALM1 Gene at MOPED

Post-translational modifications for CALM1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CALM1 (Calmodulin)

No data available for DME Specific Peptides for CALM1 Gene

Domains & Families for CALM1 Gene

Gene Families for CALM1 Gene

Protein Domains for CALM1 Gene

Graphical View of Domain Structure for InterPro Entry

P62158

UniProtKB/Swiss-Prot:

CALM_HUMAN :
  • Contains 4 EF-hand domains.
  • Belongs to the calmodulin family.
Domain:
  • Contains 4 EF-hand domains.
Family:
  • Belongs to the calmodulin family.
genes like me logo Genes that share domains with CALM1: view

No data available for Suggested Antigen Peptide Sequences for CALM1 Gene

Function for CALM1 Gene

Molecular function for CALM1 Gene

GENATLAS Biochemistry:
calmodulin 1,calcium modulated protein
UniProtKB/Swiss-Prot Function:
Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.

Gene Ontology (GO) - Molecular Function for CALM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding ISS --
GO:0005515 protein binding IPI 3111527
GO:0008179 adenylate cyclase binding IEA --
GO:0016301 kinase activity --
GO:0019901 protein kinase binding IPI 20668654
genes like me logo Genes that share ontologies with CALM1: view
genes like me logo Genes that share phenotypes with CALM1: view

Animal Model Products

miRNA for CALM1 Gene

miRTarBase miRNAs that target CALM1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CALM1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CALM1 Gene

Localization for CALM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALM1 Gene

Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CALM1 Gene COMPARTMENTS Subcellular localization image for CALM1 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
nucleus 5
plasma membrane 5
cytosol 4
endoplasmic reticulum 3
chloroplast 2
golgi apparatus 2
lysosome 2
mitochondrion 2
vacuole 2
endosome 1

Gene Ontology (GO) - Cellular Components for CALM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 16760425
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm TAS 10899953
genes like me logo Genes that share ontologies with CALM1: view

Pathways & Interactions for CALM1 Gene

SuperPathways for CALM1 Gene

Superpath Contained pathways
1 Interleukin receptor SHC signaling
2 DAG and IP3 signaling
3 Post NMDA receptor activation events
4 Development Angiotensin activation of ERK
5 Development Endothelin-1/EDNRA signaling
genes like me logo Genes that share pathways with CALM1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Cytoskeleton Regulators in human,mouse,rat
    • cAMP / Ca2+ Signaling PathwayFinder in human,mouse,rat

Gene Ontology (GO) - Biological Process for CALM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0001975 response to amphetamine IEA --
GO:0002027 regulation of heart rate IMP 23040497
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with CALM1: view

No data available for SIGNOR curated interactions for CALM1 Gene

Drugs & Compounds for CALM1 Gene

(25) Drugs for CALM1 Gene - From: DrugBank, HMDB, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aprindine Approved Pharma inhibitor, Target 0
Bepridil Approved, Withdrawn Pharma Pore Blocker, blocker, Target, binder 0
Flunarizine Approved Pharma blocker, Target 3
Dibucaine Approved Pharma Target, inhibitor 0
Felodipine Approved, Investigational Pharma Potentiation, Activator, Target, other 21
genes like me logo Genes that share compounds with CALM1: view

Transcripts for CALM1 Gene

Unigene Clusters for CALM1 Gene

Calmodulin 1 (phosphorylase kinase, delta):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CALM1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CALM1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b
SP1: - - - - - -
SP2: - - -
SP3: - -
SP4: -
SP5: -
SP6: - - - -

Relevant External Links for CALM1 Gene

GeneLoc Exon Structure for
CALM1
ECgene alternative splicing isoforms for
CALM1

Expression for CALM1 Gene

mRNA expression in normal human tissues for CALM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CALM1 Gene

This gene is overexpressed in Lavage (13.7), Bone (10.1), and Brain (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CALM1 Gene



SOURCE GeneReport for Unigene cluster for CALM1 Gene Hs.282410

genes like me logo Genes that share expression patterns with CALM1: view

Protein tissue co-expression partners for CALM1 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CALM1 Gene

Orthologs for CALM1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CALM1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CALM 35
  • 84.34 (n)
  • 98.66 (a)
CALM 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CALM2 35
  • 85.23 (n)
  • 100 (a)
CALM3 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Calm1 16
Calm1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CALM1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CALM1 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CALM1 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves CALM1 35
  • 91.28 (n)
  • 99.33 (a)
CALM 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CALM1 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10372 35
zebrafish
(Danio rerio)
Actinopterygii calm3a 36
  • 100 (a)
ManyToMany
calm3b 36
  • 100 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta And 37
  • 67 (a)
Cam 37
  • 97 (a)
CG11165 37
  • 53 (a)
Mlc-c 37
  • 46 (a)
TpnC41C 37
  • 45 (a)
Cam 36
  • 98 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cal-1 37
  • 68 (a)
cal-2 37
  • 65 (a)
cal-3 37
  • 59 (a)
cal-4 37
  • 59 (a)
cmd-1 37
  • 97 (a)
F12A10.5 37
  • 45 (a)
Y73B3A.12 37
  • 76 (a)
cal-6 36
  • 76 (a)
ManyToMany
cmd-1 36
  • 98 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMD1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons CAM7 35
  • 73.6 (n)
  • 89.93 (a)
rice
(Oryza sativa)
Liliopsida Os07g0687200 35
  • 74.94 (n)
  • 90.6 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04120 35
  • 70.02 (n)
  • 85.23 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cam1 35
  • 68.97 (n)
  • 76.55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10340 36
  • 97 (a)
OneToMany
Species with no ortholog for CALM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CALM1 Gene

ENSEMBL:
Gene Tree for CALM1 (if available)
TreeFam:
Gene Tree for CALM1 (if available)

Paralogs for CALM1 Gene

Pseudogenes.org Pseudogenes for CALM1 Gene

genes like me logo Genes that share paralogs with CALM1: view

Variants for CALM1 Gene

Sequence variations from dbSNP and Humsavar for CALM1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs5871 -- 90,405,134(+) TTTGT(C/T)TAGTA utr-variant-3-prime
rs15414 -- 90,408,180(+) GATGG(A/G)GGACC utr-variant-3-prime
rs1058903 -- 90,407,454(+) TTGAG(C/T)GAGGC utr-variant-3-prime
rs1059285 -- 90,405,453(+) ACCTT(C/T)TGAAC utr-variant-3-prime
rs1059296 -- 90,405,799(+) TGGAC(A/G)TGTAG utr-variant-3-prime

Variation tolerance for CALM1 Gene

Residual Variation Intolerance Score: 53.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CALM1 Gene

HapMap Linkage Disequilibrium report
CALM1
Human Gene Mutation Database (HGMD)
CALM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CALM1 Gene

Disorders for CALM1 Gene

MalaCards: The human disease database

(29) MalaCards diseases for CALM1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

UniProtKB/Swiss-Prot

CALM_HUMAN
  • Long QT syndrome 14 (LQT14) [MIM:616247]: A form of long QT syndrome, a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. {ECO:0000269 PubMed:23388215, ECO:0000269 PubMed:24076290}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Long QT syndrome 15 (LQT15) [MIM:616249]: A form of long QT syndrome, a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. {ECO:0000269 PubMed:23388215, ECO:0000269 PubMed:24917665}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Ventricular tachycardia, catecholaminergic polymorphic, 4 (CPVT4) [MIM:614916]: An arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Patients present with recurrent syncope, seizures, or sudden death after physical activity or emotional stress. {ECO:0000269 PubMed:23040497}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CALM1

Genetic Association Database (GAD)
CALM1
Human Genome Epidemiology (HuGE) Navigator
CALM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CALM1
genes like me logo Genes that share disorders with CALM1: view

No data available for Genatlas for CALM1 Gene

Publications for CALM1 Gene

  1. Melatonin, an endogenous-specific inhibitor of estrogen receptor alpha via calmodulin. (PMID: 15229223) del RA-o B. … Ramos S. (J. Biol. Chem. 2004) 25 26 67
  2. Vasorelaxant effect of flavonoids through calmodulin inhibition: Ex vivo, in vitro, and in silico approaches. (PMID: 21129983) Torres-Piedra M. … Estrada-Soto S. (Bioorg. Med. Chem. 2011) 25 26
  3. Rapid and transient stimulation of intracellular reactive oxygen species by melatonin in normal and tumor leukocytes. (PMID: 19463840) Radogna F. … Ghibelli L. (Toxicol. Appl. Pharmacol. 2009) 25 26
  4. Participation of glucose transporters on atrial natriuretic peptide-induced glucose uptake by adult and neonatal cardiomyocytes under oxygenation and hypoxia. (PMID: 17537429) Sosa V. … Guarner V. (Eur. J. Pharmacol. 2007) 25 26
  5. The calponin homology domain of Vav1 associates with calmodulin and is prerequisite to T cell antigen receptor-induced calcium release in Jurkat T lymphocytes. (PMID: 17550897) Zhou Z. … Cao Y. (J. Biol. Chem. 2007) 25 26

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