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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CALM1 Gene

protein-coding   GIFtS: 69
GCID: GC14P090863

Calmodulin 1 (Phosphorylase Kinase, Delta)


(Previous symbol: CALML2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Calmodulin 1 (Phosphorylase Kinase, Delta)1 2     CALM3
CALML21 2 3     CAM3
Prepro-Calmodulin 11 2     CAM13
PHKD2 5     CAM23
CAMI2     CAM33
CPVT42     CAMB3
DD1322     CAMC3
caM2     CAMIII3
calmodulin2     CaM3
Phosphorylase Kinase, Delta Subunit2     

External Ids:    HGNC: 14421   Entrez Gene: 8012   Ensembl: ENSG000001986687   OMIM: 1141805   UniProtKB: P621583   

Export aliases for CALM1 gene to outside databases

Previous GC identifers: GC14P088369 GC14P084679 GC14P088853 GC14P089933 GC14P071038


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CALM1 Gene:
This gene encodes a member of the EF-hand calcium-binding protein family. It is one of three genes which encode an
identical calcium binding protein which is one of the four subunits of phosphorylase kinase. Two pseudogenes have
been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found
for this gene.(provided by RefSeq, Oct 2009)

GeneCards Summary for CALM1 Gene: 
CALM1 (calmodulin 1 (phosphorylase kinase, delta)) is a protein-coding gene. Diseases associated with CALM1 include familial long qt syndrome, and otomycosis, and among its related super-pathways are VEGF and S-1P Signaling and Development Endothelin-1/EDNRA transactivation of EGFR. An important paralog of this gene is CALML3.

UniProtKB/Swiss-Prot: CALM_HUMAN, P62158
Function: Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+).
Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and
phosphatases. Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome
cycle and progression through cytokinesis

Gene Wiki entry for CALM1 (Calmodulin 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CALM1 gene promoter:
         STAT5B   Pax-5   MyoD   C/EBPalpha   CHOP-10   Nkx6-1   E2F-1   E2F   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCALM1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CALM1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CALM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.11   Ensembl cytogenetic band:  14q32.11   HGNC cytogenetic band: 14q32.11

CALM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALM1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P090863:  view genomic region     (about GC identifiers)

Start:
90,862,846 bp from pter      End:
90,874,619 bp from pter
Size:
11,774 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CALM_HUMAN, P62158 (See protein sequence)
Recommended Name: Calmodulin  
Size: 149 amino acids; 16838 Da
Subunit: Interacts with MYO1C and RRAD. Interacts with MYO10 (By similarity). Interacts with CEP97, CEP110,
TTN/titin and SRY. Interacts with USP6; the interaction is calcium dependent. Interacts with CDK5RAP2. Interacts
with SCN5A. Interacts with RYR1 and RYR2. Interacts with FCHO1
Subcellular location: Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed
throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and
the spindle microtubules
Miscellaneous: This protein has four functional calcium-binding sites
Sequence caution: Sequence=CAA36839.1; Type=Erroneous gene model prediction;
6/78 PDB 3D structures from and Proteopedia for CALM1 (see all 78):
1AJI (3D)        1CDL (3D)        1CLL (3D)        1CTR (3D)        1IWQ (3D)        1J7O (3D)    
Secondary accessions: P02593 P70667 P99014 Q13942 Q53S29 Q61379 Q61380 Q96HK3

Explore the universe of human proteins at neXtProt for CALM1: NX_P62158

Explore proteomics data for CALM1 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitination results in a strongly decreased activity (By similarity)
  • UniProtKB: Phosphorylation results in a decreased activity (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P62158

  • CALM1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CALM1 Protein Expression
    REFSEQ proteins: NP_008819.1  
    ENSEMBL proteins: 
     ENSP00000451062   ENSP00000349467   ENSP00000403491   ENSP00000451646   ENSP00000450829  
     ENSP00000442853   ENSP00000450425  
    Reactome Protein details: P62158
    Human Recombinant Protein Products for CALM1: 
    EMD Millipore Purified and/or Recombinant CALM1 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CALM1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CALM1
    GenScript Custom Purified and Recombinant Proteins Services for CALM1
    Novus Biologicals CALM1 Proteins
    Novus Biologicals CALM1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CALM1
    Cloud-Clone Corp. Proteins for CALM1 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole ----
    GO:0005576extracellular region ----
    GO:0005654nucleoplasm ----
    GO:0005737cytoplasm ----
    GO:0005813centrosome ----

    CALM1 for ontologies           About GeneDecksing



    CALM1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CALM1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CALM1  (calmodulin)
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    OriGene Custom Antibody Services for CALM1
    GenScript Custom Superior Antibodies Services for CALM1
    Novus Biologicals CALM1 Antibodies
    Abcam antibodies for CALM1
    Cloud-Clone Corp. Antibodies for CALM1 
    ThermoFisher Antibody for CALM1
    LSBio Antibodies in human, mouse, rat for CALM1 

    Assay Products for CALM1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CALM1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CALM1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CALM1 
    Cloud-Clone Corp. CLIAs for CALM1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands
    EFHAND: EF-hand domain containing

    4 InterPro protein domains:
     IPR001125 Recoverin
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry P62158

    ProtoNet protein and cluster: P62158

    UniProtKB/Swiss-Prot: CALM_HUMAN, P62158
    Similarity: Belongs to the calmodulin family
    Similarity: Contains 4 EF-hand domains


    CALM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CALM_HUMAN, P62158
    Function: Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+).
    Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and
    phosphatases. Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome
    cycle and progression through cytokinesis

         Genatlas biochemistry entry for CALM1:
    calmodulin 1,calcium modulated protein

         Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding ----
    GO:0005515protein binding ----
    GO:0016301kinase activity ----
    GO:0019904protein domain specific binding ----
    GO:0031432titin binding ----
         
    CALM1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CALM1:
     Decreased G3BP1 protein expres  Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CALM1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CALM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CALM1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CALM1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALM1
    8/126 QIAGEN miScript miRNA Assays for microRNAs that regulate CALM1 (see all 126):
    hsa-miR-579 hsa-miR-193a-3p hsa-miR-3194-5p hsa-miR-15a hsa-miR-3138 hsa-miR-890 hsa-miR-298 hsa-miR-3613-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CALM1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALM1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CALM1
    Sirion Biotech Customized adenovirus for overexpression of CALM1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CALM1 (see all 9)
    OriGene ORF clones in mouse, rat for CALM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CALM1 (NM_006888)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALM1
    Sirion Biotech Customized lentivirus for stable overexpression of CALM1 
                         Customized lentivirus expression plasmids for stable overexpression of CALM1 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CALM1
    Search LifeMap BioReagents cell lines for CALM1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALM1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CALM1 About   (see all 109)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    Signal transduction Activation of PKC via G-Protein coupled receptor0.42
    VEGF and S-1P Signaling0.44
    Alpha-Adrenergic Signaling0.38
    fMLP Pathway0.43
    Signal transduction Calcium signaling0.34
    2Development Endothelin-1/EDNRA signaling
    Development Endothelin-1/EDNRA signaling0.41
    GnRH signaling pathway0.38
    Development Endothelin-1/EDNRA transactivation of EGFR0.41
    Estrogen signaling pathway0.34
    Cytoskeleton remodeling FAK signaling0.41
    3Visual signal transduction- Rods
    The phototransduction cascade0.54
    Phototransduction0.46
    Inactivation, recovery and regulation of the phototransduction cascade0.51
    4Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Alzheimer's disease0.46
    Alzheimers Disease0.44
    5Signal transduction cAMP signaling
    Signal transduction cAMP signaling0.44
    G Protein Signaling Pathways0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/36 EMD Millipore Pathways for CALM1 (see all 36)
        Translation Translation regulation by Alpha-1 adrenergic receptors
    Development Activation of ERK by Alpha-1 adrenergic receptors
    Immune response CD16 signaling in NK cells
    Cytoskeleton remodeling RalB regulation pathway
    Cytoskeleton remodeling FAK signaling

    1 R&D Systems Pathway for CALM1
        Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    5/41 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CALM1 (see all 41)
        Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods
    PI3K Signaling in B-Lymphocyte
    Dopamine-DARPP32 Feedback onto cAMP Pathway
    Alpha-Adrenergic Signaling

    2 Cell Signaling Technology (CST) Pathways for CALM1
        Ca, cAMP and Lipid Signaling
    Neuroscience

    5/35 GeneGo (Thomson Reuters) Pathways for CALM1 (see all 35)
        Signal transduction cAMP signaling
    Development Endothelin-1/EDNRA signaling
    Immune response CD28 signaling
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Signal transduction Activation of PKC via G-Protein coupled receptor

    5/25 BioSystems Pathways for CALM1 (see all 25)
        MicroRNAs in cardiomyocyte hypertrophy
    Myometrial Relaxation and Contraction Pathways
    G13 Signaling Pathway
    G Protein Signaling Pathways
    Glycogen Metabolism

    5/70        Reactome Pathways for CALM1 (see all 70)
        Glycogen breakdown (glycogenolysis)
    Inositol phosphate metabolism
    Visual phototransduction
    Activation of CaMK IV
    Signaling by PDGF


    5/22         Kegg Pathways  (Kegg details for CALM1) (see all 22):
        Calcium signaling pathway
    Phosphatidylinositol signaling system
    Oocyte meiosis
    Vascular smooth muscle contraction
    Circadian entrainment


    CALM1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CALM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/612 Interacting proteins for CALM1 (P621581, 2, 3 ENSP000003494674) via UniProtKB, MINT, STRING, and/or I2D (see all 612)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CACNA1CQ139361, 2, 3, ENSP000002663764EBI-397435,EBI-1038838 MINT-8087834 MINT-8087891 MINT-8087783 MINT-8087930 MINT-8087912 MINT-8087767 MINT-8087800 MINT-8087819 MINT-8087850 MINT-8087867 I2D: score=6 STRING: ENSP00000266376
    KCNH1O952591, 2, 3, ENSP000002717514EBI-397435,EBI-2909270 MINT-7988123 MINT-7988100 I2D: score=3 STRING: ENSP00000271751
    RALBP112342, 3, ENSP000002725194MINT-16957 MINT-16956 MINT-16955 I2D: score=4 STRING: ENSP00000272519
    MYO10Q9HD672, 3, ENSP000003911064MINT-6595938 MINT-6596013 I2D: score=3 STRING: ENSP00000391106
    NFKB2Q006532, 3, ENSP000001894444MINT-48738 MINT-48603 I2D: score=2 STRING: ENSP00000189444
    About this table

    Gene Ontology (GO): 5/39 biological process terms (GO ID links to tree view) (see all 39):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001975response to amphetamine ----
    GO:0002027regulation of heart rate ----
    GO:0002576platelet degranulation ----
    GO:0005513detection of calcium ion ----
    GO:0005975carbohydrate metabolic process ----

    CALM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CALM1 (CALM)

    2 HMDB Compounds for CALM1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    LoperamideApo-Loperamide (see all 10)53179-11-6--

    10/24 DrugBank Compounds for CALM1 (see all 24)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    FelodipineDl-Felodipine (see all 4)72509-76-3targetother2964559 2442519 2833901 4074665 2933041 3178884
    Calcium-- --target--17595168 17537429 17550897 17592724 17612522
    FluphenazineFluorfenazine (see all 6)69-23-8targetinhibitor11409178 1515867 12366848 16661928 10516112
    Loperamide-- 53179-11-6targetinhibitor10991984 2820051 2851449 10949586 2836258
    PhenoxybenzamineFenossibenzamina [Dcit] (see all 6)59-96-1targetinhibitor9100252 6146911 3994963 3134891 3758070
    PimozidePimozida [INN-Spanish] (see all 2)2062-78-4targetinhibitor2386945 6146939 3134891 1965307 2120879
    PromethazineIsopromethazine (see all 12)60-87-7targetinhibitor3022601 3820316 6319437 6433001 6092486
    Dibucaine-- 85-79-0targetinhibitor6262771 8382768 6140014 7680317
    PerphenazineChlorperphenazine (see all 8)58-39-9targetinhibitor11409178 2885243 12366848 10516112
    3''-(Beta-Chloroethyl)-2'',4''-Dioxo-3, 5''-Spiro-Oxazolidino-4-Deacetoxy-Vinblastine-- --target--17139284 17016423 10592235

    Search CenterWatch for drugs/clinical trials and news about CALM1 / CALM

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CALM1 gene (2 alternative transcripts): 
    NM_006888.4  NM_001166106.1  

    Unigene Cluster for CALM1:

    Calmodulin 1 (phosphorylase kinase, delta)
    Hs.282410  [show with all ESTs]
    Unigene Representative Sequence: NM_006888
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000557020 ENST00000356978(uc001xyl.2 uc010atq.2 uc001xym.2)
    ENST00000447653 ENST00000555132 ENST00000557123 ENST00000556757 ENST00000553995
    ENST00000553630 ENST00000553542 ENST00000553964 ENST00000544280 ENST00000555267
    ENST00000553422 ENST00000554296 ENST00000556721
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/126 QIAGEN miScript miRNA Assays for microRNAs that regulate CALM1 (see all 126):
    hsa-miR-579 hsa-miR-193a-3p hsa-miR-3194-5p hsa-miR-15a hsa-miR-3138 hsa-miR-890 hsa-miR-298 hsa-miR-3613-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALM1
    Clone
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    OriGene clones in human, mouse for CALM1 (see all 9)
    OriGene ORF clones in mouse, rat for CALM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CALM1 (NM_006888)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALM1
    Sirion Biotech Customized lentivirus for stable overexpression of CALM1 
                         Customized lentivirus expression plasmids for stable overexpression of CALM1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CALM1
    OriGene qSTAR qPCR primer pairs in human, mouse for CALM1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CALM1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALM1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALM1

    Additional mRNA sequence: 

    AK289937.1 AY189287.1 BC000454.2 BC007965.2 BC008597.1 BC011834.2 BC042831.1 BT006818.1 
    BX537677.1 BX648223.1 L37715.1 M27319.1 U16850.1 

    24/47 DOTS entries (see all 47):

    DT.95203091  DT.100888491  DT.92463189  DT.91929905  DT.100888511  DT.95111250  DT.120780285  DT.120780231 
    DT.120780225  DT.120780237  DT.100034559  DT.95203069  DT.120780232  DT.95203107  DT.100888490  DT.95203053 
    DT.100888476  DT.100888499  DT.120780329  DT.92463188  DT.95203059  DT.120780148  DT.120780241  DT.120780333 

    24/1535 AceView cDNA sequences (see all 1535):

    BQ631228 BM786894 AA935946 AU122722 BU581272 AU185119 CB963277 BM559015 
    R76277 BC000454 W05654 H60495 BM976467 BI438647 BM928061 BQ067830 
    BX483234 BE500967 AI698465 AI077697 AI936204 BF594603 N42353 CB111623 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CALM1 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b
    SP1:        -     -           -           -           -           -                           
    SP2:                                      -           -           -                           
    SP3:                                      -           -                                       
    SP4:                                                              -                           
    SP5:        -                                                                                 


    ECgene alternative splicing isoforms for CALM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CALM1 expression in normal human tissues (normalized intensities)      CALM1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAAACTTAG
    CALM1 Expression
    About this image


    CALM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/24 selected tissues (see all 24) fully expand
     
     Brain (Nervous System)    fully expand to see all 22 entries
             Thalamus
             Globus Pallidus   
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             T Helper Cells Thymus
             mouse/organ system/cardiovascular system   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/atrium   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina

    See CALM1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CALM1

    SOURCE GeneReport for Unigene cluster: Hs.282410
        SABiosciences Expression via Pathway-Focused PCR Arrays including CALM1: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Cytoskeleton Regulators in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CALM1 gene from 10/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Calm15 calmodulin 1   --   12 (50.43 cM) 100199435 
    chicken
    (Gallus gallus)
    Aves CALM11 calmodulin 1 (phosphorylase kinase, delta) 91.28(n)
    99.33(a)
      396523  NM_001110364.1  NP_001103834.1 
    lizard
    (Anolis carolinensis)
    Reptilia CALM16
    CALM16
    Uncharacterized protein
    99(a)
    100(a)
    possible ortholog
    1 ↔ 1
    GL343568.1(347088-358586)
    1(12510658-12522508)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ030532.12   -- 87.36(n)    BJ030532.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC053150.12   -- 82.59(n)    BC053150.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cam1 , 3 calcium ion sensing calcium ion binding3
    Calmodulin1
    97(a)
    (best of 5)3
    77.63(n)1
    97.99(a)1
      363291  NM_078986.21  NP_523710.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cmd-11 , 3 calmodulin3
    Protein CMD-11
    97(a)
    (best of 7)3
    76.96(n)1
    97.99(a)1
      V(1156006-1157085)3
    1786141  NM_070985.41  NP_503386.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CMD1(YBR109C)4 Calmodulin; Ca++ binding protein that regulates Ca++ more   --   2(458362-457919) 852406  NP_009667.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CAM41 calmodulin 4 73.83(n)
    89.26(a)
      842959  NM_105312.3  NP_176814.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g04911001 hypothetical protein 73.83(n)
    90.6(a)
      4339172  NM_001062442.1  NP_001055907.1 


    ENSEMBL Gene Tree for CALM1 (if available)
    TreeFam Gene Tree for CALM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CALM1 gene
    CALM21 2  CALM31 2  CALML32  CABP52  CABP12  TNNC12  CABP42  CABP22  
    CALML62  TNNC22  CALML52  CABP72  CALML42  CALN12  
    18/50 SIMAP similar genes for CALM1 using alignment to 6 protein entries:     CALM_HUMAN (see all proteins) (see all similar genes):
    CALM2    CALML3    CALM3    CALML5    CETN1    TNNC2
    CETN2    TNNC1    CALN1    CABP1    CABP5    MYL12B
    MYL9    CALML6    CABP2    MYL6    MRLC3    MYL1

    CALM1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for CALM1
    PGOHUM00000260211 PGOHUM00000260323 PGOHUM00000260974


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/319 SNPs in CALM1 are shown (see all 319)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0692234
    Ventricular tachycardia, catecholaminergic polymorphic 4 (CPVT4)4--see VAR_0692232 N S mis40--------
    VAR_0692224
    Ventricular tachycardia, catecholaminergic polymorphic 4 (CPVT4)4--see VAR_0692222 N I mis40--------
    VAR_0485854
    ----see VAR_0485852 M T mis40--------
    rs619890661,2
    C--71047057(+) CTTAAA/GGAAAA 1 -- ut310--------
    rs1839178491,2
    --71846579(+) CACTGC/GAACCT 1 -- us2k10--------
    rs1471057821,2
    --71846581(+) CTGCAA/GCCTCC 1 -- us2k10--------
    rs37597091,2
    C--71846583(-) tcggaC/Ggttgc 1 -- us2k10--------
    rs1871138661,2
    --71846587(+) CCTCCA/GATGCC 1 -- us2k10--------
    rs37597081,2
    C,F,H--71846736(-) ATCACG/AAGGTC 1 -- us2k18Minor allele frequency- A:0.11NA WA CSA 18
    rs1471682751,2
    --71846820(+) ATAAGA/GAGTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CALM1 (90862846 - 90874619 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CALM1: --

    Human Gene Mutation Database (HGMD): CALM1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CALM1
    DNA2.0 Custom Variant and Variant Library Synthesis for CALM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 114180    OMIM disorders: --

    UniProtKB/Swiss-Prot: CALM_HUMAN, P62158
  • Ventricular tachycardia, catecholaminergic polymorphic 4 (CPVT4) [MIM:614916]: An arrhythmogenic disorder
    characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest
    and cause sudden death. Patients present with recurrent syncope, seizures, or sudden death after physical
    activity or emotional stress. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • 20/33 diseases for CALM1 (see all 33):    About MalaCards
    familial long qt syndrome    otomycosis    pseudoachondroplasia    multiple epiphyseal dysplasia
    malignant hyperthermia    lymphangioleiomyomatosis    scoliosis    toxic encephalopathy
    lissencephaly    hiv type 1    tetanus    tuberous sclerosis
    temporal lobe epilepsy    brain disease    anorexia nervosa    pertussis
    cholera    vascular disease    osteoarthritis    cystic fibrosis

    8 diseases from the University of Copenhagen DISEASES database for CALM1:
    Vascular disease     Cancer     Cholera     Pertussis
    Toxic encephalopathy     Otomycosis     Pseudoachondroplasia     Malignant hyperthermia

    CALM1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): CALM1
    Human Genome Epidemiology (HuGE) Navigator: CALM1 (19 documents)

    Export disorders for CALM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CALM1 gene, integrated from 9 sources (see all 379):
    (articles sorted by number of sources associating them with CALM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and nucleotide sequence of a cDNA encoding human calmodulin. (PubMed id 6385987)1, 2, 3 Wawrzynczak E.J. and Perham R.N. (1984)
    2. Mutations in calmodulin cause ventricular tachycardia and sudden cardiac death. (PubMed id 23040497)1, 2 Nyegaard M.... Borglum A.D. (2012)
    3. Solution NMR structure of Apo-calmodulin in complex with the IQ motif of human cardiac sodium channel NaV1.5. (PubMed id 21167176)1, 2 Chagot B. and Chazin W.J. (2011)
    4. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (2010)
    5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    6. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. (2009)
    7. Lack of association between the CALM1 core promoter polymorphism (-16C/T) and susceptibility to knee osteoarthritis in a Chinese Han population. (PubMed id 18940010)1, 4 Shi D....Jiang Q. (2008)
    8. [Is camodulin1 gene/estrogen receptor-alpha gene polymorphisms correlated with double curve pattern of adolescent idiopathic scoliosis?] (PubMed id 19080622)1, 4 Zhao D....Wang Y.P. (2008)
    9. Association of the CALM1 core promoter polymorphism with knee osteoarthritis in patients of Greek origin. (PubMed id 18452398)1, 4 Poulou M....Tzetis M. (2008)
    10. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1, 4 Shiffman D....Psaty B.M. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 801 HGNC: 1442 AceView: CALM1 Ensembl:ENSG00000198668 euGenes: HUgn801
    ECgene: CALM1 Kegg: 801 H-InvDB: CALM1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CALM1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CALM1 Genetics and Cytogenetics in Oncology and Haematology
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt105.shtml

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CALM1 gene:
    Search GeneIP for patents involving CALM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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