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CALM1 Gene

protein-coding   GIFtS: 69
GCID: GC14P090863

Calmodulin 1 (Phosphorylase Kinase, Delta)


(Previous symbol: CALML2)
  See CALM1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calmodulin 1 (Phosphorylase Kinase, Delta)1 2     CALM3
CALML21 2 3     CAM3
Prepro-Calmodulin 11 2     CAM13
CPVT42 5     CAM23
PHKD2 5     CAM33
CAMI2     CAMB3
DD1322     CAMC3
caM2     CAMIII3
calmodulin2     CaM3
Phosphorylase Kinase, Delta Subunit2     

External Ids:    HGNC: 14421   Entrez Gene: 8012   Ensembl: ENSG000001986687   OMIM: 1141805   UniProtKB: P621583   

Export aliases for CALM1 gene to outside databases

Previous GC identifers: GC14P088369 GC14P084679 GC14P088853 GC14P089933 GC14P071038


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CALM1 Gene:
This gene encodes a member of the EF-hand calcium-binding protein family. It is one of three genes which encode an
identical calcium binding protein which is one of the four subunits of phosphorylase kinase. Two pseudogenes have
been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found
for this gene.(provided by RefSeq, Oct 2009)

GeneCards Summary for CALM1 Gene:
CALM1 (calmodulin 1 (phosphorylase kinase, delta)) is a protein-coding gene. Diseases associated with CALM1 include calm1-related catecholaminergic polymorphic ventricular tachycardia, and ventricular tachycardia, catecholaminergic polymorphic, 4. An important paralog of this gene is CALML3.

UniProtKB/Swiss-Prot: CALM_HUMAN, P62158
Function: Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other
proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein
kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the
centrosome cycle and progression through cytokinesis

Gene Wiki entry for CALM1 (Calmodulin 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CALM1 gene promoter:
         STAT5B   Pax-5   MyoD   C/EBPalpha   CHOP-10   Nkx6-1   E2F-1   E2F   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCALM1 promoter sequence
   Search Chromatin IP Primers for CALM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CALM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.11   Ensembl cytogenetic band:  14q32.11   HGNC cytogenetic band: 14q32.11

CALM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALM1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P090863:  view genomic region     (about GC identifiers)

Start:
90,862,846 bp from pter      End:
90,874,619 bp from pter
Size:
11,774 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CALM_HUMAN, P62158 (See protein sequence)
Recommended Name: Calmodulin  
Size: 149 amino acids; 16838 Da
Subunit: Interacts with MYO1C and RRAD. Interacts with MYO10 (By similarity). Interacts with CEP97, CCP110,
TTN/titin and SRY. Interacts with USP6; the interaction is calcium dependent. Interacts with CDK5RAP2. Interacts
with SCN5A. Interacts with RYR1 and RYR2. Interacts with FCHO1. Interacts with MIP in a 1:2 stoichiometry; the
interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure
Miscellaneous: This protein has four functional calcium-binding sites
Sequence caution: Sequence=CAA36839.1; Type=Erroneous gene model prediction;
Selected PDB 3D structures from and Proteopedia for CALM1 (see all 84):
1AJI (3D)        1CDL (3D)        1CLL (3D)        1CTR (3D)        1IWQ (3D)        1J7O (3D)    
Secondary accessions: P02593 P70667 P99014 Q13942 Q53S29 Q61379 Q61380 Q96HK3

Explore the universe of human proteins at neXtProt for CALM1: NX_P62158

Explore proteomics data for CALM1 at MOPED

Post-translational modifications: 

  • Ubiquitination results in a strongly decreased activity (By similarity)1
  • Phosphorylation results in a decreased activity (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CALM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008819.1  
    ENSEMBL proteins: 
     ENSP00000451062   ENSP00000349467   ENSP00000403491   ENSP00000451646   ENSP00000450829  
     ENSP00000442853   ENSP00000450425  
    Reactome Protein details: P62158

    CALM1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CALM1 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CALM1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CALM1
    GenScript Custom Purified and Recombinant Proteins Services for CALM1
    Novus Biologicals CALM1 Proteins
    Novus Biologicals CALM1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CALM1
    Cloud-Clone Corp. Proteins for CALM1

     
    Search eBioscience for Proteins for CALM1 

    CALM1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CALM1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CALM1  (calmodulin)
    OriGene Antibodies for CALM1
    OriGene Custom Antibody Services for CALM1
    Novus Biologicals CALM1 Antibodies
    Abcam antibodies for CALM1
    Cloud-Clone Corp. Antibodies for CALM1
    ThermoFisher Antibody for CALM1
    LSBio Antibodies in human, mouse, rat for CALM1

    CALM1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CALM1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CALM1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CALM1
    Cloud-Clone Corp. CLIAs for CALM1
    Search eBioscience for ELISAs for CALM1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    EFHAND: EF-hand domain containing

    4 InterPro protein domains:
     IPR001125 Recoverin_like
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry P62158

    ProtoNet protein and cluster: P62158

    UniProtKB/Swiss-Prot: CALM_HUMAN, P62158
    Similarity: Belongs to the calmodulin family
    Similarity: Contains 4 EF-hand domains


    Find genes that share domains with CALM1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CALM_HUMAN, P62158
    Function: Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other
    proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein
    kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the
    centrosome cycle and progression through cytokinesis

         Genatlas biochemistry entry for CALM1:
    calmodulin 1,calcium modulated protein

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding ----
    GO:0005515protein binding ----
    GO:0016301kinase activity ----
    GO:0019904protein domain specific binding ----
    GO:0031432titin binding ----
         
    Find genes that share ontologies with CALM1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CALM1:
     Decreased G3BP1 protein expres  Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CALM1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CALM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CALM1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CALM1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CALM1:
    hsa-mir-1 (MIRT024054)

    Block miRNA regulation of human, mouse, rat CALM1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CALM1 (see all 126):
    hsa-miR-579 hsa-miR-193a-3p hsa-miR-3194-5p hsa-miR-15a hsa-miR-3138 hsa-miR-890 hsa-miR-298 hsa-miR-3613-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CALM1
    Predesigned siRNA for gene silencing in human, mouse, rat CALM1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CALM1

    Clone
    Products:
         
    OriGene clones in human, mouse for CALM1 (see all 8)
    OriGene ORF clones in mouse, rat for CALM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CALM1 (NM_006888)
    Sino Biological Human cDNA Clone for CALM1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALM1
    Addgene plasmids for CALM1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CALM1
    Browse ESI BIO Cell Lines and PureStem Progenitors for CALM1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALM1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CALM_HUMAN, P62158: Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Distributed
    throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and
    the spindle microtubules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol4
    extracellular4
    nucleus4
    endoplasmic reticulum3
    golgi apparatus2
    mitochondrion2
    vacuole2
    chloroplast1
    endosome1
    lysosome1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole ----
    GO:0005576extracellular region ----
    GO:0005654nucleoplasm ----
    GO:0005737cytoplasm ----
    GO:0005813centrosome ----

    Find genes that share ontologies with CALM1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CALM1 About   (see all 106)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Ca-dependent events
    DAG and IP3 signaling0.94
    PLC beta mediated events0.67
    EGFR interacts with phospholipase C-gamma0.94
    G-protein mediated events0.65
    PLC-gamma1 signalling0.94
    Phospholipase C-mediated cascade0.59
    CaM pathway0.93
    Opioid Signalling0.54
    2Post NMDA receptor activation events
    Post NMDA receptor activation events0.90
    CREB phosphorylation through the activation of CaMKII0.00
    Activation of NMDA receptor upon glutamate binding and postsynaptic events0.90
    Activation of CaMK IV0.00
    CREB phosphorylation through the activation of Ras0.78
    CaMK IV-mediated phosphorylation of CREB0.00
    Long-term potentiation0.35
    CREB phosphorylation through the activation of CaMKK0.00
    3Development Endothelin 1 EDNRA signaling
    Development Endothelin 1 EDNRA signaling0.41
    GnRH signaling pathway0.38
    Development Endothelin 1 EDNRA transactivation of EGFR0.41
    Inflammatory mediator regulation of TRP channels0.37
    Cytoskeleton remodeling FAK signaling0.41
    Estrogen signaling pathway0.34
    4fMLP Pathway
    CCR3 Pathway in Eosinophils0.44
    Signal transduction Activation of PKC via G Protein coupled receptor0.42
    VEGF and S-1P Signaling0.44
    Alpha-Adrenergic Signaling0.38
    fMLP Pathway0.43
    5ADP signalling through P2Y purinoceptor 12
    Activation of Kainate Receptors upon glutamate binding0.68
    Activation of Ca-permeable Kainate Receptor0.35
    Development Angiotensin signaling via beta Arrestin0.39
    Ionotropic activity of Kainate Receptors0.00


    Find genes that share SuperPaths with CALM1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CALM1
        Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CALM1 (see all 41)
        Intracellular Calcium Signaling
    Visual Cycle in Retinal Rods
    PI3K Signaling in B-Lymphocyte
    Dopamine-DARPP32 Feedback onto cAMP Pathway
    Alpha-Adrenergic Signaling

    2 Cell Signaling Technology (CST) Pathways for CALM1
        Ca, cAMP and Lipid Signaling
    Neuroscience

    Selected GeneGo (Thomson Reuters) Pathways for CALM1 (see all 35)
        Signal transduction cAMP signaling
    Development Endothelin-1/EDNRA signaling
    Immune response CD28 signaling
    Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Signal transduction Activation of PKC via G-Protein coupled receptor

    Selected BioSystems Pathways for CALM1 (see all 26)
        Myometrial Relaxation and Contraction Pathways
    MicroRNAs in cardiomyocyte hypertrophy
    G13 Signaling Pathway
    G Protein Signaling Pathways
    Glycogen Metabolism


    Selected Reactome Pathways for CALM1 (see all 22)
        Glycogen breakdown (glycogenolysis)
    Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
    Inactivation, recovery and regulation of the phototransduction cascade
    DARPP-32 events
    Activation of CaMK IV


    Selected Kegg Pathways  (Kegg details for CALM1) (see all 27):
        Ras signaling pathway
    Rap1 signaling pathway
    Calcium signaling pathway
    Phosphatidylinositol signaling system
    Oocyte meiosis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CALM1: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Cytoskeleton Regulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CALM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CALM1 (P621581, 2, 3 ENSP000003494674) via UniProtKB, MINT, STRING, and/or I2D (see all 694)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CACNA1CQ139361, 2, 3, ENSP000002663764EBI-397435,EBI-1038838 MINT-8087834 MINT-8087891 MINT-8087783 MINT-8087930 MINT-8087912 MINT-8087767 MINT-8087800 MINT-8087819 MINT-8087850 MINT-8087867 I2D: score=6 STRING: ENSP00000266376
    KCNH1O952591, 2, 3, ENSP000002717514EBI-397435,EBI-2909270 MINT-7988123 MINT-7988100 I2D: score=3 STRING: ENSP00000271751
    MYO10Q9HD671, 2, 3, ENSP000003911064EBI-397435,EBI-307061 MINT-6595938 MINT-6596013 I2D: score=3 STRING: ENSP00000391106
    RCHY1Q96PM51, 2, 3, ENSP000003212394EBI-397435,EBI-947779 MINT-5114562 MINT-5114545 I2D: score=2 STRING: ENSP00000321239
    TTNQ8WZ421, 2, 3EBI-397435,EBI-681210 MINT-7899812 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 39):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001975response to amphetamine ----
    GO:0002027regulation of heart rate ----
    GO:0002576platelet degranulation ----
    GO:0005513detection of calcium ion ----
    GO:0005975carbohydrate metabolic process ----

    Find genes that share ontologies with CALM1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CALM1 (CALM)

    2 HMDB Compounds for CALM1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    LoperamideApo-Loperamide (see all 10)53179-11-6--

    Selected DrugBank Compounds for CALM1 (see all 24)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    FelodipineDl-Felodipine (see all 4)72509-76-3targetother2964559 2442519 2833901 4074665 2933041 3178884
    Calcium-- --target--17595168 17537429 17550897 17592724 17612522
    FluphenazineFluorfenazine (see all 6)69-23-8targetinhibitor11409178 1515867 12366848 16661928 10516112
    Loperamide-- 53179-11-6targetinhibitor10991984 2820051 2851449 10949586 2836258
    PhenoxybenzamineFenossibenzamina [Dcit] (see all 6)59-96-1targetinhibitor9100252 6146911 3994963 3134891 3758070
    PimozidePimozida [INN-Spanish] (see all 2)2062-78-4targetinhibitor2386945 6146939 3134891 1965307 2120879
    PromethazineIsopromethazine (see all 12)60-87-7targetinhibitor3022601 3820316 6319437 6433001 6092486
    Dibucaine-- 85-79-0targetinhibitor6262771 8382768 6140014 7680317
    PerphenazineChlorperphenazine (see all 8)58-39-9targetinhibitor11409178 2885243 12366848 10516112
    3''-(Beta-Chloroethyl)-2'',4''-Dioxo-3, 5''-Spiro-Oxazolidino-4-Deacetoxy-Vinblastine-- --target--17139284 17016423 10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CALM1 gene (2 alternative transcripts): 
    NM_006888.4  NM_001166106.1  

    Unigene Cluster for CALM1:

    Calmodulin 1 (phosphorylase kinase, delta)
    Hs.282410  [show with all ESTs]
    Unigene Representative Sequence: NM_006888
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000557020 ENST00000356978(uc001xyl.2 uc010atq.2 uc001xym.2)
    ENST00000447653 ENST00000555132 ENST00000557123 ENST00000556757 ENST00000553995
    ENST00000553630 ENST00000553542 ENST00000553964 ENST00000544280 ENST00000555267
    ENST00000553422 ENST00000554296 ENST00000556721
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CALM1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CALM1 (see all 126):
    hsa-miR-579 hsa-miR-193a-3p hsa-miR-3194-5p hsa-miR-15a hsa-miR-3138 hsa-miR-890 hsa-miR-298 hsa-miR-3613-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CALM1
    Predesigned siRNA for gene silencing in human, mouse, rat CALM1
    Clone
    Products:
         
    OriGene clones in human, mouse for CALM1 (see all 8)
    OriGene ORF clones in mouse, rat for CALM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CALM1 (NM_006888)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALM1
    Addgene plasmids for CALM1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CALM1
    OriGene qSTAR qPCR primer pairs in human, mouse for CALM1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CALM1
      QuantiTect SYBR Green Assays in human, mouse, rat CALM1
      QuantiFast Probe-based Assays in human, mouse, rat CALM1

    Additional mRNA sequence: 

    AK289937.1 AY189287.1 BC000454.2 BC007965.2 BC008597.1 BC011834.2 BC042831.1 BT006818.1 
    BX537677.1 BX648223.1 L37715.1 M27319.1 U16850.1 

    Selected DOTS entries (see all 47):

    DT.95203091  DT.100888491  DT.92463189  DT.91929905  DT.100888511  DT.95111250  DT.120780285  DT.120780231 
    DT.120780225  DT.120780237  DT.100034559  DT.95203069  DT.120780232  DT.95203107  DT.100888490  DT.95203053 
    DT.100888476  DT.100888499  DT.120780329  DT.92463188  DT.95203059  DT.120780148  DT.120780241  DT.120780333 

    Selected AceView cDNA sequences (see all 1535):

    BI772654 BE842534 AV728020 R95963 BE048721 CB159028 AA070962 BC008597 
    AW163770 AI912158 BP371051 AW301226 AA488568 W05654 AI929824 CR611512 
    BM787158 BQ084184 CB963277 BU188852 AW900174 W61315 BU167594 AW051407 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CALM1 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b
    SP1:        -     -           -           -           -           -                           
    SP2:                                      -           -           -                           
    SP3:                                      -           -                                       
    SP4:                                                              -                           
    SP5:        -                                                                                 


    ECgene alternative splicing isoforms for CALM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CALM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAAACTTAG
    CALM1 Expression
    About this image


    CALM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 11 entries
             Thalamus
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
    CALM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CALM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.282410
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CALM1: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Cytoskeleton Regulators in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CALM1 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Calm15 calmodulin 1   --   12 (50.43 cM) 100199435 
    chicken
    (Gallus gallus)
    Aves CALM11 calmodulin 1 (phosphorylase kinase, delta) 91.28(n)
    99.33(a)
      396523  NM_001110364.1  NP_001103834.1 
    lizard
    (Anolis carolinensis)
    Reptilia CALM16
    calmodulin 1 (phosphorylase kinase, delta)
    100(a)
    1 ↔ 1
    1(12510658-12522508)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ030532.12   -- 87.36(n)    BJ030532.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC053150.12   -- 82.59(n)    BC053150.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cam3 calcium ion sensing calcium ion binding 97(a)
    (best of 5)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea cmd-13 calmodulin 97(a)
    (best of 7)
      V(1156006-1157085)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CAM71 CAM7 73.6(n)
    89.93(a)
      823492  NM_114249.3  NP_189967.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g06872001 Os07g0687200 74.94(n)
    90.6(a)
      4344344  NM_001067226.1  NP_001060691.1 


    ENSEMBL Gene Tree for CALM1 (if available)
    TreeFam Gene Tree for CALM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CALM1 gene
    CALM21 2  CALM31 2  CALML32  CABP52  CABP12  TNNC12  CABP42  CABP22  
    CALML62  TNNC22  CALML52  CALML42  
    Selected SIMAP similar genes for CALM1 using alignment to 5 protein entries:     CALM_HUMAN (see all proteins) (see all similar genes):
    CALM2    CALML3    CALM3    CALML5    CETN1    TNNC2
    CETN2    TNNC1    CALN1    CABP1    MYL12B    MYL9
    CABP5    CALML6    CABP2    MYL6    MYL1    MYL4

    Find genes that share paralogs with CALM1           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for CALM1
    PGOHUM00000260211 PGOHUM00000260323 PGOHUM00000260974


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CALM1 (see all 319)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0692234
    Ventricular tachycardia, catecholaminergic polymorphic, 4 (CPVT4)4--see VAR_0692232 N S mis40--------
    VAR_0692224
    Ventricular tachycardia, catecholaminergic polymorphic, 4 (CPVT4)4--see VAR_0692222 N I mis40--------
    rs619890661,2
    C--71047057(+) CTTAAA/GGAAAA 1 -- ut310--------
    rs1839178491,2
    --71846579(+) CACTGC/GAACCT 1 -- us2k10--------
    rs1471057821,2
    --71846581(+) CTGCAA/GCCTCC 1 -- us2k10--------
    rs37597091,2
    C--71846583(-) tcggaC/Ggttgc 1 -- us2k10--------
    rs1871138661,2
    --71846587(+) CCTCCA/GATGCC 1 -- us2k10--------
    rs37597081,2
    C,F,H--71846736(-) ATCACG/AAGGTC 1 -- us2k18Minor allele frequency- A:0.11NA WA CSA 18
    rs1471682751,2
    --71846820(+) ATAAGA/GAGTTT 1 -- us2k10--------
    rs1395364641,2
    --71846873(+) TAAAAC/TTAATT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CALM1 (90862846 - 90874619 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CALM1: --
    Human Gene Mutation Database (HGMD): CALM1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CALM1
    DNA2.0 Custom Variant and Variant Library Synthesis for CALM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 114180   
    OMIM disorders: 614916  
    UniProtKB/Swiss-Prot: CALM_HUMAN, P62158
  • Ventricular tachycardia, catecholaminergic polymorphic, 4 (CPVT4) [MIM:614916]: An arrhythmogenic
    disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac
    arrest and cause sudden death. Patients present with recurrent syncope, seizures, or sudden death after physical
    activity or emotional stress. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • 5 diseases for CALM1:    
    About MalaCards
    calm1-related catecholaminergic polymorphic ventricular tachycardia    ventricular tachycardia, catecholaminergic polymorphic, 4    otomycosis    ventricular tachycardia, catecholaminergic polymorphic, 2
    catecholaminergic polymorphic ventricular tachycardia

    8 diseases from the University of Copenhagen DISEASES database for CALM1:
    Vascular disease     Cancer     Cholera     Pertussis
    Toxic encephalopathy     Otomycosis     Pseudoachondroplasia     Malignant hyperthermia

    Find genes that share disorders with CALM1           About GenesLikeMe

    Genetic Association Database (GAD): CALM1
    Human Genome Epidemiology (HuGE) Navigator: CALM1 (19 documents)

    Export disorders for CALM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CALM1 gene, integrated from 10 sources (see all 391):
    (articles sorted by number of sources associating them with CALM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and nucleotide sequence of a cDNA encoding human calmodulin. (PubMed id 6385987)1, 2, 3 Wawrzynczak E.J. and Perham R.N. (Biochem. Int. 1984)
    2. Mutations in calmodulin cause ventricular tachycardia and sudden cardiac death. (PubMed id 23040497)1, 2 Nyegaard M.... Borglum A.D. (Am. J. Hum. Genet. 2012)
    3. Solution NMR structure of Apo-calmodulin in complex with the IQ motif of human cardiac sodium channel NaV1.5. (PubMed id 21167176)1, 2 Chagot B. and Chazin W.J. (J. Mol. Biol. 2011)
    4. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. ( a journal of cerebral circulation 2009)
    7. Lack of association between the CALM1 core promoter polymorphism (-16C/T) and susceptibility to knee osteoarthritis in a Chinese Han population. (PubMed id 18940010)1, 4 Shi D....Jiang Q. (BMC Med. Genet. 2008)
    8. [Is calmodulin 1 gene/estrogen receptor-alpha gene polymorphisms correlated with double curve pattern of adolescent idiopathic scoliosis?]. (PubMed id 19080622)1, 4 Zhao D....Wang Y.P. (Zhonghua Yi Xue Za Zhi 2008)
    9. Association of the CALM1 core promoter polymorphism with knee osteoarthritis in patients of Greek origin. (PubMed id 18452398)1, 4 Poulou M....Tzetis M. (Genet. Test. 2008)
    10. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1, 4 Shiffman D....Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 801 HGNC: 1442 AceView: CALM1 Ensembl:ENSG00000198668 euGenes: HUgn801
    ECgene: CALM1 Kegg: 801 H-InvDB: CALM1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CALM1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CALM1 Genetics and Cytogenetics in Oncology and Haematology
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/105

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CALM1 gene:
    Search GeneIP for patents involving CALM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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