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Aliases for CALHM6 Gene

Aliases for CALHM6 Gene

  • Calcium Homeostasis Modulator Family Member 6 2 3
  • Family With Sequence Similarity 26 Member F 2 3 5
  • FAM26F 3 4 5
  • IFN Regulatory Factor 3-Dependent NK-Activating Molecule 2 3
  • C6orf187 3 4
  • Family With Sequence Similarity 26, Member F 2
  • Chromosome 6 Open Reading Frame 187 2
  • Protein FAM26F 3
  • DJ93H18.5 3
  • INAM 3

External Ids for CALHM6 Gene

Previous HGNC Symbols for CALHM6 Gene

  • C6orf187
  • FAM26F

Summaries for CALHM6 Gene

GeneCards Summary for CALHM6 Gene

CALHM6 (Calcium Homeostasis Modulator Family Member 6) is a Protein Coding gene. An important paralog of this gene is CALHM5.

UniProtKB/Swiss-Prot for CALHM6 Gene

  • Pore-forming subunit of a voltage-gated ion channel.

Additional gene information for CALHM6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALHM6 Gene

Genomics for CALHM6 Gene

Regulatory Elements for CALHM6 Gene

Enhancers for CALHM6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H116461 1.3 FANTOM5 Ensembl ENCODE 41.7 +2.3 2285 4 MXI1 BACH1 MAX BMI1 E2F1 CTBP1 ZNF316 POLR2A SCRT2 RUNX3 CALHM6 DSE ENSG00000234117 TRAPPC3L RWDD1 TSPYL1 ZUFSP ENSG00000244158
GH06H116450 1.3 FANTOM5 Ensembl ENCODE 35.3 -10.1 -10060 1 L3MBTL2 GTF2E2 MAX ELF1 NFIC IKZF1 EED ZNF24 MLLT1 RUNX3 CALHM6 ENSG00000234117 CALHM4 RSPH4A DSE ZUFSP CBX3P9 PIR34878
GH06H116384 1.8 FANTOM5 Ensembl ENCODE dbSUPER 24.2 -71.9 -71914 9 PKNOX1 BATF ZNF366 FOS ATF7 ETV6 RUNX3 CREM IKZF2 YY2 DSE CALHM6 CALHM4 CBX3P9 KRT18P22 ENSG00000244158 ENSG00000234117 TRAPPC3L ENSG00000240050 TSPYL1
GH06H116409 1.6 FANTOM5 Ensembl ENCODE dbSUPER 20.9 -50.3 -50306 3 ZSCAN4 BATF ATF7 ETV6 RUNX3 CREM IKZF2 ELF1 ZNF217 PRDM6 CALHM6 DSE CBX3P9 KRT18P22 ENSG00000244158 CALHM4 ENSG00000234117 RWDD1 PIR34878 PIR33476
GH06H116446 1.3 FANTOM5 Ensembl ENCODE 25.7 -14.1 -14105 2 PKNOX1 NFIA CEBPB CEBPG RAD21 PRDM6 ZBTB48 POLR2A ZSCAN5C SMC3 CALHM6 CALHM4 ENSG00000234117 DSE ZUFSP CBX3P9 PIR34878
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CALHM6 on UCSC Golden Path with GeneCards custom track

Promoters for CALHM6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000201674 830 801 MXI1 BACH1 MAX BMI1 E2F1 CTBP1 POLR2A EZH2 ZNF687 RNF2

Genomic Location for CALHM6 Gene

Chromosome:
6
Start:
116,461,370 bp from pter
End:
116,463,782 bp from pter
Size:
2,413 bases
Orientation:
Plus strand

Genomic View for CALHM6 Gene

Genes around CALHM6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALHM6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALHM6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALHM6 Gene

Proteins for CALHM6 Gene

  • Protein details for CALHM6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5R3K3-FA26F_HUMAN
    Recommended name:
    Protein FAM26F
    Protein Accession:
    Q5R3K3
    Secondary Accessions:
    • B9EJB0
    • Q5R3K4

    Protein attributes for CALHM6 Gene

    Size:
    315 amino acids
    Molecular mass:
    34458 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CALHM6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CALHM6 Gene

Post-translational modifications for CALHM6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CALHM6 Gene

No data available for DME Specific Peptides for CALHM6 Gene

Domains & Families for CALHM6 Gene

Gene Families for CALHM6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CALHM6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CALHM6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5R3K3

UniProtKB/Swiss-Prot:

FA26F_HUMAN :
  • Belongs to the FAM26 family.
Family:
  • Belongs to the FAM26 family.
genes like me logo Genes that share domains with CALHM6: view

Function for CALHM6 Gene

Molecular function for CALHM6 Gene

UniProtKB/Swiss-Prot Function:
Pore-forming subunit of a voltage-gated ion channel.

Phenotypes From GWAS Catalog for CALHM6 Gene

Gene Ontology (GO) - Molecular Function for CALHM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005261 cation channel activity IBA --
genes like me logo Genes that share ontologies with CALHM6: view
genes like me logo Genes that share phenotypes with CALHM6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CALHM6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CALHM6 Gene

Localization for CALHM6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALHM6 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CALHM6 gene
Compartment Confidence
plasma membrane 5
nucleus 2

Gene Ontology (GO) - Cellular Components for CALHM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CALHM6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CALHM6 Gene

Pathways & Interactions for CALHM6 Gene

SuperPathways for CALHM6 Gene

No Data Available

Interacting Proteins for CALHM6 Gene

Gene Ontology (GO) - Biological Process for CALHM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0034220 ion transmembrane transport IBA --
GO:0098655 cation transmembrane transport IEA --
genes like me logo Genes that share ontologies with CALHM6: view

No data available for Pathways by source and SIGNOR curated interactions for CALHM6 Gene

Drugs & Compounds for CALHM6 Gene

No Compound Related Data Available

Transcripts for CALHM6 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CALHM6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CALHM6 Gene

No ASD Table

Relevant External Links for CALHM6 Gene

GeneLoc Exon Structure for
CALHM6
ECgene alternative splicing isoforms for
CALHM6

Expression for CALHM6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of CALHM6 Gene:

CALHM6

Evidence on tissue expression from TISSUES for CALHM6 Gene

  • Lung(2.9)
  • Spleen(2.3)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with CALHM6: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CALHM6 Gene

Orthologs for CALHM6 Gene

This gene was present in the common ancestor of animals.

Orthologs for CALHM6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM26F 34 33
  • 99.47 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FAM26F 33 34
  • 85.38 (n)
cow
(Bos Taurus)
Mammalia FAM26F 33 34
  • 85.36 (n)
rat
(Rattus norvegicus)
Mammalia Fam26f 33
  • 77.38 (n)
mouse
(Mus musculus)
Mammalia Fam26f 16 34 33
  • 77.14 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 59 (a)
OneToMany
-- 34
  • 42 (a)
OneToMany
chicken
(Gallus gallus)
Aves FAM26F 33 34
  • 59.41 (n)
lizard
(Anolis carolinensis)
Reptilia FAM26F 34
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731134 33
  • 58.88 (n)
zebrafish
(Danio rerio)
Actinopterygii fam26f 34 33
  • 51.08 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea clhm-1 34
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 16 (a)
OneToMany
Species where no ortholog for CALHM6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CALHM6 Gene

ENSEMBL:
Gene Tree for CALHM6 (if available)
TreeFam:
Gene Tree for CALHM6 (if available)

Paralogs for CALHM6 Gene

Paralogs for CALHM6 Gene

genes like me logo Genes that share paralogs with CALHM6: view

Variants for CALHM6 Gene

Sequence variations from dbSNP and Humsavar for CALHM6 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000611244 -- 116,463,212(+) AACTT(C/T)ATCTG intron-variant
rs1000937351 -- 116,460,701(+) GTCTA(G/T)TCCCC upstream-variant-2KB
rs1000955888 -- 116,463,462(+) AAAGA(A/G)AATAT reference, synonymous-codon
rs1001389699 -- 116,461,087(+) TGGGT(A/T)CAACT upstream-variant-2KB
rs1001442558 -- 116,462,463(+) TGCCG(C/T)TGGCG intron-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CALHM6 Gene

Variant ID Type Subtype PubMed ID
nsv523972 CNV gain 19592680
nsv830783 CNV gain 17160897

Variation tolerance for CALHM6 Gene

Gene Damage Index Score: 9.46; 88.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CALHM6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CALHM6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALHM6 Gene

Disorders for CALHM6 Gene

Relevant External Links for CALHM6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CALHM6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CALHM6

No disorders were found for CALHM6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CALHM6 Gene

Publications for CALHM6 Gene

  1. Structural and functional annotation of human FAM26F: A multifaceted protein having a critical role in the immune system. (PMID: 27784631) Malik U … Asghar K (Gene 2017) 2 3 60
  2. FAM26F: An Enigmatic Protein Having a Complex Role in the Immune System. (PMID: 27645024) Malik U … Javed A (International reviews of immunology 2016) 2 3 60
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 60
  4. A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis. (PMID: 25082827) Julià A … Marsal S (Human molecular genetics 2014) 3 60
  5. CBFβ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. (PMID: 23333304) Kim DY … Gross JD (Molecular cell 2013) 3 60

Products for CALHM6 Gene

Sources for CALHM6 Gene

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