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Aliases for CALHM4 Gene

Aliases for CALHM4 Gene

  • Calcium Homeostasis Modulator Family Member 4 2 3
  • Family With Sequence Similarity 26 Member D 2 3 5
  • FAM26D 3 4 5
  • C6orf78 3 4
  • Family With Sequence Similarity 26, Member D 2
  • Chromosome 6 Open Reading Frame 78 2
  • Protein FAM26D 3

External Ids for CALHM4 Gene

Previous HGNC Symbols for CALHM4 Gene

  • C6orf78
  • FAM26D

Summaries for CALHM4 Gene

GeneCards Summary for CALHM4 Gene

CALHM4 (Calcium Homeostasis Modulator Family Member 4) is a Protein Coding gene. An important paralog of this gene is CALHM2.

UniProtKB/Swiss-Prot for CALHM4 Gene

  • Pore-forming subunit of a voltage-gated ion channel.

Additional gene information for CALHM4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALHM4 Gene

Genomics for CALHM4 Gene

Regulatory Elements for CALHM4 Gene

Enhancers for CALHM4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H116384 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -139.5 -139543 9.7 PKNOX1 BATF ZNF366 FOS ATF7 ETV6 RUNX3 CREM IKZF2 YY2 DSE CALHM6 CALHM4 CBX3P9 KRT18P22 ENSG00000244158 ENSG00000234117 TRAPPC3L ENSG00000240050 TSPYL1
GH06H116409 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -117.9 -117935 3.1 ZSCAN4 BATF ATF7 ETV6 RUNX3 CREM IKZF2 ELF1 ZNF217 PRDM6 CALHM6 DSE CBX3P9 KRT18P22 ENSG00000244158 CALHM4 ENSG00000234117 RWDD1 PIR34878 PIR33476
GH06H116276 1.4 ENCODE dbSUPER 12.3 -249.6 -249573 5.1 HDGF FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 ZNF766 CALHM6 TSPYL4 CALHM4 TSPYL1 TRAPPC3L KRT18P22 CBX3P9 ENSG00000244158 ENSG00000234117 ZUFSP
GH06H116403 1.4 Ensembl ENCODE dbSUPER 11.3 -123.1 -123125 4.5 PKNOX1 TBL1XR1 ZFP64 ZSCAN5C ZNF350 ZNF143 FOS ETV6 RUNX3 IKZF2 KRT18P22 CALHM4 CBX3P9 CALHM6 ENSG00000244158 ENSG00000234117 TRAPPC3L DSE PIR34878 PIR33476
GH06H116446 1.3 FANTOM5 Ensembl ENCODE 11.8 -81.7 -81734 2.3 PKNOX1 NFIA CEBPB CEBPG RAD21 PRDM6 ZBTB48 POLR2A ZSCAN5C SMC3 CALHM6 CALHM4 ENSG00000234117 DSE ZUFSP CBX3P9 PIR34878
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CALHM4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CALHM4 Gene

Genomic Locations for CALHM4 Gene
chr6:116,528,999-116,561,123
(GRCh38/hg38)
Size:
32,125 bases
Orientation:
Plus strand
chr6:116,850,174-116,880,031
(GRCh37/hg19)

Genomic View for CALHM4 Gene

Genes around CALHM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALHM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALHM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALHM4 Gene

Proteins for CALHM4 Gene

  • Protein details for CALHM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JW98-FA26D_HUMAN
    Recommended name:
    Protein FAM26D
    Protein Accession:
    Q5JW98
    Secondary Accessions:
    • B0QZ25
    • B0QZ27
    • B4DTQ0
    • Q96MK0

    Protein attributes for CALHM4 Gene

    Size:
    314 amino acids
    Molecular mass:
    35060 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CALHM4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CALHM4 Gene

Post-translational modifications for CALHM4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CALHM4 Gene

Domains & Families for CALHM4 Gene

Gene Families for CALHM4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for CALHM4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CALHM4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JW98

UniProtKB/Swiss-Prot:

FA26D_HUMAN :
  • Belongs to the FAM26 family.
Family:
  • Belongs to the FAM26 family.
genes like me logo Genes that share domains with CALHM4: view

Function for CALHM4 Gene

Molecular function for CALHM4 Gene

UniProtKB/Swiss-Prot Function:
Pore-forming subunit of a voltage-gated ion channel.

Phenotypes From GWAS Catalog for CALHM4 Gene

Gene Ontology (GO) - Molecular Function for CALHM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005261 cation channel activity IBA --
genes like me logo Genes that share ontologies with CALHM4: view
genes like me logo Genes that share phenotypes with CALHM4: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CALHM4 Gene

Localization for CALHM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALHM4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CALHM4 gene
Compartment Confidence
plasma membrane 3
extracellular 3

Gene Ontology (GO) - Cellular Components for CALHM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CALHM4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CALHM4 Gene

Pathways & Interactions for CALHM4 Gene

SuperPathways for CALHM4 Gene

No Data Available

Interacting Proteins for CALHM4 Gene

Gene Ontology (GO) - Biological Process for CALHM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0034220 ion transmembrane transport IBA --
GO:0098655 cation transmembrane transport IEA --
genes like me logo Genes that share ontologies with CALHM4: view

No data available for Pathways by source and SIGNOR curated interactions for CALHM4 Gene

Drugs & Compounds for CALHM4 Gene

No Compound Related Data Available

Transcripts for CALHM4 Gene

mRNA/cDNA for CALHM4 Gene

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CALHM4 Gene

No ASD Table

Relevant External Links for CALHM4 Gene

GeneLoc Exon Structure for
CALHM4
ECgene alternative splicing isoforms for
CALHM4

Expression for CALHM4 Gene

NURSA nuclear receptor signaling pathways regulating expression of CALHM4 Gene:

CALHM4
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CALHM4 Gene

Orthologs for CALHM4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CALHM4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM26D 33 34
  • 99.61 (n)
dog
(Canis familiaris)
Mammalia FAM26D 33 34
  • 86.94 (n)
cow
(Bos Taurus)
Mammalia FAM26D 33 34
  • 84.12 (n)
mouse
(Mus musculus)
Mammalia Fam26d 33 16 34
  • 80.51 (n)
rat
(Rattus norvegicus)
Mammalia Fam26d 33
  • 80.31 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM26D 34
  • 35 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM26D 34
  • 23 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea clhm-1 34
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 6 (a)
OneToMany
Species where no ortholog for CALHM4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CALHM4 Gene

ENSEMBL:
Gene Tree for CALHM4 (if available)
TreeFam:
Gene Tree for CALHM4 (if available)

Paralogs for CALHM4 Gene

Paralogs for CALHM4 Gene

genes like me logo Genes that share paralogs with CALHM4: view

Variants for CALHM4 Gene

Sequence variations from dbSNP and Humsavar for CALHM4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000057975 -- 116,528,385(+) CCAGA(A/G)GTACA intron-variant, upstream-variant-2KB
rs1000100044 -- 116,554,642(+) ATACA(A/T)TACCA intron-variant
rs1000160627 -- 116,553,060(+) CAGAG(C/G)GAGAC intron-variant, upstream-variant-2KB
rs1000213322 -- 116,553,606(+) TCAGC(C/T)GTAAT intron-variant, utr-variant-5-prime
rs1000388554 -- 116,559,689(+) TAAAA(A/G)GGATG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CALHM4 Gene

Variant ID Type Subtype PubMed ID
nsv523972 CNV gain 19592680
nsv830783 CNV gain 17160897

Variation tolerance for CALHM4 Gene

Residual Variation Intolerance Score: 78.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.19; 69.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CALHM4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CALHM4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALHM4 Gene

Disorders for CALHM4 Gene

Relevant External Links for CALHM4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CALHM4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CALHM4

No disorders were found for CALHM4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CALHM4 Gene

Publications for CALHM4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for CALHM4 Gene

Sources for CALHM4 Gene

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