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Aliases for CALHM3 Gene

Aliases for CALHM3 Gene

  • Calcium Homeostasis Modulator 3 2 3 5
  • Family With Sequence Similarity 26, Member A 2 3
  • FAM26A 3 4
  • Calcium Homeostasis Modulator Protein 3 3
  • Protein FAM26A 4
  • BA225H22.7 3

External Ids for CALHM3 Gene

Previous HGNC Symbols for CALHM3 Gene

  • FAM26A

Previous GeneCards Identifiers for CALHM3 Gene

  • GC10M105223
  • GC10M098863

Summaries for CALHM3 Gene

GeneCards Summary for CALHM3 Gene

CALHM3 (Calcium Homeostasis Modulator 3) is a Protein Coding gene. GO annotations related to this gene include cation channel activity. An important paralog of this gene is CALHM1.

UniProtKB/Swiss-Prot for CALHM3 Gene

  • Pore-forming subunit of a voltage-gated ion channel.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALHM3 Gene

Genomics for CALHM3 Gene

Regulatory Elements for CALHM3 Gene

Enhancers for CALHM3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F103480 1.2 Ensembl ENCODE 0.8 -1.5 -1520 0.9 NFIA SCRT2 CALHM2 AS3MT CALHM3 NEURL1
GH10F103479 1.2 Ensembl ENCODE 0.8 -0.3 -253 1.0 KLF1 PKNOX1 JUN KLF17 ZNF316 GLIS2 CTBP1 RCOR1 FOSL2 FOS AS3MT CALHM3 NEURL1
GH10F103476 0.7 Ensembl ENCODE 0.8 +2.4 2440 0.8 HDGF CTCF TFAP4 MAX ZIC2 RAD21 RELA POLR2A ZNF143 SMC3 AS3MT MARCKSL1P1 CALHM3 CALHM1
GH10F103482 0.2 ENCODE 0.8 -2.9 -2869 0.2 CTCF LEF1 MAX ZNF48 RAD21 FOXK2 NCOR1 SMC3 GATAD2A SMARCA5 CALHM3 NEURL1
GH10F103469 0.8 FANTOM5 Ensembl ENCODE 0.4 +7.7 7740 4.2 TBP HDAC1 PKNOX1 KLF17 EGR1 ETV6 FOS CREM CBFB JUNB AS3MT NEURL1 NEURL1-AS1 CALHM2 RNU11-3P NT5C2 CALHM3 CALHM1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CALHM3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CALHM3 Gene

Chromosome:
10
Start:
103,472,804 bp from pter
End:
103,479,240 bp from pter
Size:
6,437 bases
Orientation:
Minus strand

Genomic View for CALHM3 Gene

Genes around CALHM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALHM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALHM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALHM3 Gene

Proteins for CALHM3 Gene

  • Protein details for CALHM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XJ0-CAHM3_HUMAN
    Recommended name:
    Calcium homeostasis modulator protein 3
    Protein Accession:
    Q86XJ0
    Secondary Accessions:
    • Q5W090
    • Q8IXR2

    Protein attributes for CALHM3 Gene

    Size:
    350 amino acids
    Molecular mass:
    39087 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CALHM3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CALHM3 Gene

Post-translational modifications for CALHM3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CALHM3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CALHM3 Gene

Domains & Families for CALHM3 Gene

Protein Domains for CALHM3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CALHM3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86XJ0

UniProtKB/Swiss-Prot:

CAHM3_HUMAN :
  • Belongs to the FAM26 family.
Family:
  • Belongs to the FAM26 family.
genes like me logo Genes that share domains with CALHM3: view

No data available for Gene Families for CALHM3 Gene

Function for CALHM3 Gene

Molecular function for CALHM3 Gene

UniProtKB/Swiss-Prot Function:
Pore-forming subunit of a voltage-gated ion channel.

Gene Ontology (GO) - Molecular Function for CALHM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005261 cation channel activity IBA --
genes like me logo Genes that share ontologies with CALHM3: view
genes like me logo Genes that share phenotypes with CALHM3: view

Animal Model Products

miRNA for CALHM3 Gene

miRTarBase miRNAs that target CALHM3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CALHM3 Gene

Localization for CALHM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALHM3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CALHM3 Gene COMPARTMENTS Subcellular localization image for CALHM3 gene
Compartment Confidence
plasma membrane 4
nucleus 3
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CALHM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CALHM3: view

Pathways & Interactions for CALHM3 Gene

SuperPathways for CALHM3 Gene

No Data Available

Interacting Proteins for CALHM3 Gene

Gene Ontology (GO) - Biological Process for CALHM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0034220 ion transmembrane transport IBA --
GO:0098655 cation transmembrane transport IEA --
genes like me logo Genes that share ontologies with CALHM3: view

No data available for Pathways by source and SIGNOR curated interactions for CALHM3 Gene

Transcripts for CALHM3 Gene

mRNA/cDNA for CALHM3 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CALHM3 Gene

Calcium homeostasis modulator 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CALHM3 Gene

No ASD Table

Relevant External Links for CALHM3 Gene

GeneLoc Exon Structure for
CALHM3
ECgene alternative splicing isoforms for
CALHM3

Expression for CALHM3 Gene

mRNA expression in normal human tissues for CALHM3 Gene

mRNA differential expression in normal tissues according to GTEx for CALHM3 Gene

This gene is overexpressed in Testis (x6.4) and Pancreas (x5.5).

NURSA nuclear receptor signaling pathways regulating expression of CALHM3 Gene:

CALHM3

SOURCE GeneReport for Unigene cluster for CALHM3 Gene:

Hs.364624

mRNA Expression by UniProt/SwissProt for CALHM3 Gene:

Q86XJ0-CAHM3_HUMAN
Tissue specificity: Specifically expressed in circumvallate taste bud cells.
genes like me logo Genes that share expression patterns with CALHM3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CALHM3 Gene

Orthologs for CALHM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CALHM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CALHM3 34 35
  • 99.22 (n)
cow
(Bos Taurus)
Mammalia CALHM3 34 35
  • 88.28 (n)
dog
(Canis familiaris)
Mammalia CALHM3 34 35
  • 87.79 (n)
mouse
(Mus musculus)
Mammalia Calhm3 35
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Calhm3 34
  • 82.95 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CALHM3 35
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CALHM3 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves CALHM3 34 35
  • 67.6 (n)
lizard
(Anolis carolinensis)
Reptilia CALHM3 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489522 34
  • 64.63 (n)
zebrafish
(Danio rerio)
Actinopterygii calhm3 34 35
  • 56.47 (n)
worm
(Caenorhabditis elegans)
Secernentea clhm-1 35
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 12 (a)
OneToMany
Species where no ortholog for CALHM3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CALHM3 Gene

ENSEMBL:
Gene Tree for CALHM3 (if available)
TreeFam:
Gene Tree for CALHM3 (if available)

Paralogs for CALHM3 Gene

Paralogs for CALHM3 Gene

(2) SIMAP similar genes for CALHM3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CALHM3: view

Variants for CALHM3 Gene

Sequence variations from dbSNP and Humsavar for CALHM3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs11191700 -- 103,474,153(+) CATCC(A/G)TCCTG intron-variant
rs11191701 -- 103,474,282(+) TAAAT(C/T)CGTCA intron-variant
rs11191702 -- 103,474,429(+) CCATC(C/T)ATCAT intron-variant
rs11191703 -- 103,474,702(+) CACCC(A/G)CCTCG intron-variant
rs11191704 -- 103,475,711(+) TGTGT(A/C)GTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CALHM3 Gene

Variant ID Type Subtype PubMed ID
dgv966n100 CNV gain 25217958
esv3577694 CNV gain 25503493
nsv518987 CNV loss 19592680
nsv524966 CNV loss 19592680

Variation tolerance for CALHM3 Gene

Gene Damage Index Score: 7.29; 81.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CALHM3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CALHM3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALHM3 Gene

Disorders for CALHM3 Gene

Relevant External Links for CALHM3

Genetic Association Database (GAD)
CALHM3
Human Genome Epidemiology (HuGE) Navigator
CALHM3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CALHM3

No disorders were found for CALHM3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CALHM3 Gene

Publications for CALHM3 Gene

  1. A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk. (PMID: 18585350) Dreses-Werringloer U. … Marambaud P. (Cell 2008) 2 3 4 64
  2. Genetic association between CALHM1, 2, and 3 polymorphisms and Alzheimer's disease in a Japanese population. (PMID: 20164573) Shibata N. … Arai H. (J. Alzheimers Dis. 2010) 3 46 64
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for CALHM3 Gene

Sources for CALHM3 Gene

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