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Aliases for CALHM3 Gene

Aliases for CALHM3 Gene

  • Calcium Homeostasis Modulator 3 2 3
  • Family With Sequence Similarity 26, Member A 2 3
  • FAM26A 3 4
  • Protein FAM26A 4
  • BA225H22.7 3

External Ids for CALHM3 Gene

Previous HGNC Symbols for CALHM3 Gene

  • FAM26A

Previous GeneCards Identifiers for CALHM3 Gene

  • GC10M105223
  • GC10M098863

Summaries for CALHM3 Gene

GeneCards Summary for CALHM3 Gene

CALHM3 (Calcium Homeostasis Modulator 3) is a Protein Coding gene. GO annotations related to this gene include cation channel activity. An important paralog of this gene is FAM26F.

UniProtKB/Swiss-Prot for CALHM3 Gene

  • Pore-forming subunit of a voltage-gated ion channel.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALHM3 Gene

Genomics for CALHM3 Gene

Regulatory Elements for CALHM3 Gene

Genomic Location for CALHM3 Gene

103,472,804 bp from pter
103,479,240 bp from pter
6,437 bases
Minus strand

Genomic View for CALHM3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CALHM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALHM3 Gene

Proteins for CALHM3 Gene

  • Protein details for CALHM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcium homeostasis modulator protein 3
    Protein Accession:
    Secondary Accessions:
    • Q5W090
    • Q8IXR2

    Protein attributes for CALHM3 Gene

    350 amino acids
    Molecular mass:
    39087 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CALHM3 Gene


neXtProt entry for CALHM3 Gene

Proteomics data for CALHM3 Gene at MOPED

Post-translational modifications for CALHM3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CALHM3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CALHM3 Gene

Domains & Families for CALHM3 Gene

Protein Domains for CALHM3 Gene


Suggested Antigen Peptide Sequences for CALHM3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM26 family.
  • Belongs to the FAM26 family.
genes like me logo Genes that share domains with CALHM3: view

No data available for Gene Families for CALHM3 Gene

Function for CALHM3 Gene

Molecular function for CALHM3 Gene

UniProtKB/Swiss-Prot Function:
Pore-forming subunit of a voltage-gated ion channel.

Gene Ontology (GO) - Molecular Function for CALHM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005261 cation channel activity IBA --
genes like me logo Genes that share ontologies with CALHM3: view
genes like me logo Genes that share phenotypes with CALHM3: view

Animal Model Products

CRISPR Products

miRNA for CALHM3 Gene

miRTarBase miRNAs that target CALHM3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CALHM3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CALHM3 Gene

Localization for CALHM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALHM3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CALHM3 Gene COMPARTMENTS Subcellular localization image for CALHM3 gene
Compartment Confidence
nucleus 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for CALHM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
genes like me logo Genes that share ontologies with CALHM3: view

Pathways & Interactions for CALHM3 Gene

SuperPathways for CALHM3 Gene

No Data Available

Interacting Proteins for CALHM3 Gene

Gene Ontology (GO) - Biological Process for CALHM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006812 cation transport --
GO:0034220 ion transmembrane transport IBA --
GO:0098655 cation transmembrane transport IBA --
genes like me logo Genes that share ontologies with CALHM3: view

No data available for Pathways by source and SIGNOR curated interactions for CALHM3 Gene

Drugs & Compounds for CALHM3 Gene

No Compound Related Data Available

Transcripts for CALHM3 Gene

mRNA/cDNA for CALHM3 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CALHM3 Gene

Calcium homeostasis modulator 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CALHM3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CALHM3 Gene

No ASD Table

Relevant External Links for CALHM3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CALHM3 Gene

mRNA expression in normal human tissues for CALHM3 Gene

mRNA differential expression in normal tissues according to GTEx for CALHM3 Gene

This gene is overexpressed in Testis (x6.4) and Pancreas (x5.5).

SOURCE GeneReport for Unigene cluster for CALHM3 Gene Hs.364624

mRNA Expression by UniProt/SwissProt for CALHM3 Gene

Tissue specificity: Specifically expressed in circumvallate taste bud cells.
genes like me logo Genes that share expression patterns with CALHM3: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CALHM3 Gene

Orthologs for CALHM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CALHM3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CALHM3 35
  • 88.28 (n)
  • 88.37 (a)
  • 88 (a)
(Canis familiaris)
Mammalia CALHM3 35
  • 87.79 (n)
  • 90.41 (a)
  • 91 (a)
(Pan troglodytes)
Mammalia CALHM3 35
  • 99.22 (n)
  • 99.13 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Calhm3 35
  • 82.95 (n)
  • 85.47 (a)
(Monodelphis domestica)
Mammalia CALHM3 36
  • 66 (a)
(Mus musculus)
Mammalia Calhm3 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia CALHM3 36
  • 68 (a)
(Gallus gallus)
Aves CALHM3 35
  • 67.6 (n)
  • 62.19 (a)
  • 62 (a)
(Anolis carolinensis)
Reptilia CALHM3 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489522 35
  • 64.63 (n)
  • 65.31 (a)
(Danio rerio)
Actinopterygii calhm3 35
  • 56.47 (n)
  • 52.05 (a)
calhm3 36
  • 49 (a)
(Caenorhabditis elegans)
Secernentea clhm-1 36
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 12 (a)
Species with no ortholog for CALHM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CALHM3 Gene

Gene Tree for CALHM3 (if available)
Gene Tree for CALHM3 (if available)

Paralogs for CALHM3 Gene

Paralogs for CALHM3 Gene

(2) SIMAP similar genes for CALHM3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CALHM3: view

Variants for CALHM3 Gene

Sequence variations from dbSNP and Humsavar for CALHM3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs2860194 -- 103,477,030(+) TGGGA(A/C)AATTC intron-variant
rs2986034 -- 103,472,823(+) ACTAA(A/G)GTCAT utr-variant-3-prime
rs2986035 -- 103,473,353(+) GCGGT(C/T)CACCT missense, reference
rs3014198 -- 103,474,011(+) GTGTC(C/G)TTGTA intron-variant
rs3014199 -- 103,476,168(+) GCACT(C/T)CCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CALHM3 Gene

Variant ID Type Subtype PubMed ID
nsv518987 CNV Loss 19592680
nsv524966 CNV Loss 19592680

Variation tolerance for CALHM3 Gene

Gene Damage Index Score: 7.29; 81.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CALHM3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALHM3 Gene

Disorders for CALHM3 Gene

Relevant External Links for CALHM3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CALHM3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CALHM3 Gene

Publications for CALHM3 Gene

  1. A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk. (PMID: 18585350) Dreses-Werringloer U. … Marambaud P. (Cell 2008) 2 67
  2. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PMID: 23974872) Ripke S. … Sullivan P.F. (Nat. Genet. 2013) 67
  3. Genetic association between CALHM1, 2, and 3 polymorphisms and Alzheimer's disease in a Japanese population. (PMID: 20164573) Shibata N. … Arai H. (J. Alzheimers Dis. 2010) 67
  4. Expression of genes encoding multi-transmembrane proteins in specific primate taste cell populations. (PMID: 19997627) Moyer B.D. … Zlotnik A. (PLoS ONE 2009) 67
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 67

Products for CALHM3 Gene

Sources for CALHM3 Gene

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