CALHM3 Gene
protein-coding GIFtS: 39
GCID: GC10M105223
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calcium homeostasis modulator 3(Previous names: family with sequence similarity 26, member A )
(Previous symbol: FAM26A)
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Aliases
for CALHM3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Calcium Homeostasis Modulator 31 2 | | FAM26A1 2 3 | | BA225H22.71 | | Family With Sequence Similarity 26, Member A1 2 | | Calcium Homeostasis Modulator Protein 32 | | Protein FAM26A3 |
Export aliases for CALHM3 gene to outside databasesPrevious GC identifer: GC10M098863 |
Summaries
for CALHM3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CALHM3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CALHM3 gene promoter:
AhR AML1a NF-kappaB YY1 CREB deltaCREB NF-kappaB2 TGIF NF-kappaB1 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for CALHM3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CALHM3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q24.33 Ensembl cytogenetic band: 10q24.33 HGNC cytogenetic band: 10q24.33CALHM3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M105223: view genomic region
(about GC identifiers)
Start:
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105,232,561 bp from pter |
End:
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105,238,997 bp from pter |
Size:
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6,437 bases |
Orientation:
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minus strand |
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Proteins
for CALHM3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CAHM3_HUMAN, Q86XJ0 (See
protein sequence)Recommended Name: Calcium homeostasis modulator protein 3 Size: 350 amino acids; 39087 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q5W090 Q8IXR2Alternative splicing: 2 isoforms: Q86XJ0-1 Q86XJ0-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CALHM3: NX_Q86XJ0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86XJ0
CALHM3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001123214.1
ENSEMBL proteins: ENSP00000358798
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
CALHM3 for ontologies About GeneDecksing
CALHM3 Antibody Products:
Assay Products for CALHM3: |
Protein
Domains /
Families
for CALHM3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q86XJ0 UniProtKB/Swiss-Prot: CAHM3_HUMAN, Q86XJ0Similarity: Belongs to the FAM26 family |
Function
for CALHM3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CALHM3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CALHM3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CALHM3 (NM_001129742) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CALHM3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALHM3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALHM3 |
4 GenomeRNAi human phenotypes for CALHM3:
|
Pathways & Interactions
for CALHM3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CALHM3
|
Drugs & Compounds
for CALHM3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CALHM3
Search CenterWatch for drugs/clinical trials and news about CALHM3 / CAHM3
|
Transcripts
for CALHM3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CALHM3 gene (2 alternative transcripts): NM_182494.1 NM_001129742.1 Unigene Cluster for CALHM3: Calcium homeostasis modulator 3 Hs.364624 [show with all ESTs]Unigene Representative Sequence: NM_0011297421 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000369783(uc001kxg.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CALHM3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CALHM3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CALHM3 (NM_001129742) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CALHM3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALHM3 |
Additional cDNA sequence: BC039499.1 BC043367.1 1 DOTS entry: DT.95147551 7 AceView cDNA sequences: BM477085 BC039499 BC043367 NM_182494 BQ013291 CF529650 BI260920
GeneLoc Exon Structure
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Expression
for CALHM3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CALHM3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTTCTGGGT
About this image
See CALHM3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CALHM3
SOURCE GeneReport for Unigene cluster: Hs.364624
SABiosciences Custom PCR Arrays for CALHM3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CALHM3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CALHM3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALHM3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALHM3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALHM3 |
Orthologs
for CALHM3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CALHM3 gene from 4/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CALHM31 |
calcium homeostasis modulator 3 |
67.71(n)
62.58(a) |
|
428978 XM_426535.2 XP_426535.2 |
lizard
(Anolis carolinensis) |
Reptilia |
CALHM36 |
-- |
57(a) |
1 ↔ 1 |
3(40739009-40747725) |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC1000051301 |
calcium homeostasis modulator protein 3-like |
56.91(n)
52.73(a) |
|
100005130 XM_001344224.1 XP_001344260.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
clhm-16 |
Protein CLHM-1 |
19(a) |
1 → many |
II(6868899-6870796) |
Species with no ortholog for CALHM3
ENSEMBL Gene Tree for CALHM3 (if available)
TreeFam Gene Tree for CALHM3 (if available) |
Paralogs
for CALHM3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CALHM3 gene
- CALHM12 FAM26D2 FAM26F2 CALHM22 FAM26E2
2 SIMAP similar genes for CALHM3 using alignment to 1 protein entry: CAHM3_HUMAN:CALHM1 CALHM2
CALHM3 for paralogs About GeneDecksing
|
Genomic Variants
for CALHM3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CALHM3 (105232561 - 105238997 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CALHM3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CALHM3 |
|
Disorders
/ Diseases
for CALHM3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CALHM3 for disorders About GeneDecksing
1  disease for CALHM3: About MalaCardsalzheimer's disease
Human Genome Epidemiology (HuGE) Navigator: CALHM3 (2 documents)
Export disorders for CALHM3 gene to outside databases
|
Publications
for CALHM3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CALHM3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CALHM3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk. (PubMed id 18585350)1, 2, 3 Dreses-Werringloer U....Marambaud P. (2008)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Genetic Association Between CALHM1, 2, and 3 Polymorp hisms and Alzheimer's Disease in a Japanese Population. (PubMed id 20164573)1 Shibata N....Arai H. (2010)
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for CALHM3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing CALHM3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CALHM3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CALHM3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CALHM3 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for CALHM3 gene:
Search GeneIP for patents involving CALHM3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CALHM3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CALHM3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CALHM3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CALHM3 | | | OriGene Protein Over-expression Lysate for CALHM3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CALHM3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CALHM3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CALHM3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CALHM3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CALHM3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CALHM3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALHM3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALHM3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALHM3 |
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 |  |  |  | |
| | | | Search Tocris compounds for CALHM3 |
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 | | | CALHM3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALHM3 |
|  |  |  | | | | Search ThermoFisher Antibodies for CALHM3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALHM3 |
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