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Aliases for CALHM2 Gene

Aliases for CALHM2 Gene

  • Calcium Homeostasis Modulator 2 2 3 5
  • Family With Sequence Similarity 26, Member B 2 3
  • FAM26B 3 4
  • Calcium Homeostasis Modulator Protein 2 3
  • Protein FAM26B 4

External Ids for CALHM2 Gene

Previous HGNC Symbols for CALHM2 Gene

  • FAM26B

Previous GeneCards Identifiers for CALHM2 Gene

  • GC10M105197
  • GC10M105206
  • GC10M098837

Summaries for CALHM2 Gene

GeneCards Summary for CALHM2 Gene

CALHM2 (Calcium Homeostasis Modulator 2) is a Protein Coding gene. GO annotations related to this gene include cation channel activity. An important paralog of this gene is FAM26E.

UniProtKB/Swiss-Prot for CALHM2 Gene

  • Pore-forming subunit of a voltage-gated ion channel.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALHM2 Gene

Genomics for CALHM2 Gene

Regulatory Elements for CALHM2 Gene

Enhancers for CALHM2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G102772 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +673.7 673720 11.8 FOXA2 PKNOX1 ZFP64 SIN3A YY1 ZNF121 GLIS2 GATA2 FOS ZNF263 PDCD11 SFXN2 ARL3 PPRC1 TAF5 LDB1 AS3MT INA BORCS7 CYP17A1
GH10G102743 1.4 ENCODE dbSUPER 12.4 +708.0 707997 2.7 HDGF PKNOX1 AGO1 ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF207 FOS SFXN2 AS3MT ARL3 PDCD11 PPRC1 CALHM2 WBP1L CYP17A1 PFN1P11 PTGES3P4
GH10G103692 1.5 FANTOM5 ENCODE dbSUPER 10.5 -240.3 -240336 1.5 HDGF PKNOX1 ZNF133 ZNF2 GLIS2 ZNF416 ZNF143 ZNF207 SP3 TSHZ1 ENSG00000260461 SLK PDCD11 CALHM2 STN1 AS3MT ENSG00000222503 GC10M103742
GH10G103470 1.5 FANTOM5 Ensembl ENCODE 10.2 -19.5 -19529 3.1 HDAC1 TBP PKNOX1 KLF17 EGR1 FOS RELB ETV6 IKZF2 CREM NEURL1 AS3MT NEURL1-AS1 CALHM2 RNU11-3P NT5C2 CALHM3 CALHM1
GH10G102449 1.2 ENCODE 12.4 +999.2 999225 8.0 CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 MEF2D GLIS1 ARL3 PDCD11 TAF5 RPARP-AS1 PPRC1 INA CALHM2 KCNIP2-AS1 MFSD13A ST13P13
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CALHM2 on UCSC Golden Path with GeneCards custom track

Promoters for CALHM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000032879 605 1601 PKNOX1 NFIB SIN3A KLF17 NFXL1 BRCA1 RFX5 EGR1 SCRT2 RCOR1

Genomic Location for CALHM2 Gene

Chromosome:
10
Start:
103,446,785 bp from pter
End:
103,452,405 bp from pter
Size:
5,621 bases
Orientation:
Minus strand

Genomic View for CALHM2 Gene

Genes around CALHM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALHM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALHM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALHM2 Gene

Proteins for CALHM2 Gene

  • Protein details for CALHM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HA72-CAHM2_HUMAN
    Recommended name:
    Calcium homeostasis modulator protein 2
    Protein Accession:
    Q9HA72
    Secondary Accessions:
    • D3DR94
    • O95893
    • Q6ZUV9

    Protein attributes for CALHM2 Gene

    Size:
    323 amino acids
    Molecular mass:
    36175 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CALHM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CALHM2 Gene

Post-translational modifications for CALHM2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for CALHM2 Gene

Domains & Families for CALHM2 Gene

Protein Domains for CALHM2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CALHM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HA72

UniProtKB/Swiss-Prot:

CAHM2_HUMAN :
  • Belongs to the FAM26 family.
Family:
  • Belongs to the FAM26 family.
genes like me logo Genes that share domains with CALHM2: view

No data available for Gene Families for CALHM2 Gene

Function for CALHM2 Gene

Molecular function for CALHM2 Gene

UniProtKB/Swiss-Prot Function:
Pore-forming subunit of a voltage-gated ion channel.

Gene Ontology (GO) - Molecular Function for CALHM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005261 cation channel activity IBA --
genes like me logo Genes that share ontologies with CALHM2: view

Phenotypes for CALHM2 Gene

genes like me logo Genes that share phenotypes with CALHM2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CALHM2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CALHM2 Gene

Localization for CALHM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALHM2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CALHM2 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for CALHM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CALHM2: view

Pathways & Interactions for CALHM2 Gene

SuperPathways for CALHM2 Gene

No Data Available

Interacting Proteins for CALHM2 Gene

Selected Interacting proteins: Q9HA72-CAHM2_HUMAN for CALHM2 Gene via IID

Symbol External ID(s) Details
MAPK3
TNFRSF19

Gene Ontology (GO) - Biological Process for CALHM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0034220 ion transmembrane transport IBA --
GO:0098655 cation transmembrane transport IEA --
genes like me logo Genes that share ontologies with CALHM2: view

No data available for Pathways by source and SIGNOR curated interactions for CALHM2 Gene

Transcripts for CALHM2 Gene

Unigene Clusters for CALHM2 Gene

Calcium homeostasis modulator 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CALHM2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e ^ 7
SP1: - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: -
SP7: - -
SP8: - - - - - - - - -
SP9: - - -
SP10: - - - - - - - - - - -
SP11: - - - -
SP12: - - - - - - -
SP13: - - - - - - -

Relevant External Links for CALHM2 Gene

GeneLoc Exon Structure for
CALHM2
ECgene alternative splicing isoforms for
CALHM2

Expression for CALHM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CALHM2 Gene

Protein differential expression in normal tissues from HIPED for CALHM2 Gene

This gene is overexpressed in Uterus (24.7), Pancreas (13.6), and Ovary (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CALHM2 Gene



NURSA nuclear receptor signaling pathways regulating expression of CALHM2 Gene:

CALHM2

SOURCE GeneReport for Unigene cluster for CALHM2 Gene:

Hs.241545

Evidence on tissue expression from TISSUES for CALHM2 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with CALHM2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CALHM2 Gene

Orthologs for CALHM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CALHM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CALHM2 34 35
  • 99.48 (n)
cow
(Bos Taurus)
Mammalia CALHM2 34 35
  • 89.78 (n)
dog
(Canis familiaris)
Mammalia CALHM2 34 35
  • 89.78 (n)
rat
(Rattus norvegicus)
Mammalia Calhm2 34
  • 87.75 (n)
mouse
(Mus musculus)
Mammalia Calhm2 34 16 35
  • 87.33 (n)
oppossum
(Monodelphis domestica)
Mammalia CALHM2 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CALHM2 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves CALHM2 34 35
  • 77.74 (n)
lizard
(Anolis carolinensis)
Reptilia CALHM2 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia calhm2 34
  • 65.83 (n)
MGC76165 34
zebrafish
(Danio rerio)
Actinopterygii calhm2 34 35
  • 60.85 (n)
CALHM2 (2 of 2) 35
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea clhm-1 35
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 14 (a)
OneToMany
Species where no ortholog for CALHM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CALHM2 Gene

ENSEMBL:
Gene Tree for CALHM2 (if available)
TreeFam:
Gene Tree for CALHM2 (if available)

Paralogs for CALHM2 Gene

Paralogs for CALHM2 Gene

(4) SIMAP similar genes for CALHM2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CALHM2: view

Variants for CALHM2 Gene

Sequence variations from dbSNP and Humsavar for CALHM2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000036322 -- 103,448,308(+) CTCCT(A/G)GCTAA intron-variant
rs1000409972 -- 103,450,555(+) AGGGC(A/G)TGTCC intron-variant, utr-variant-5-prime
rs1000494063 -- 103,447,958(+) CACAC(-/AT)GTGCT intron-variant
rs1000905244 -- 103,452,720(+) GGAGG(G/T)TGTCG upstream-variant-2KB
rs1001108417 -- 103,446,768(+) CAATC(A/G)CACAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CALHM2 Gene

Variant ID Type Subtype PubMed ID
dgv280e212 CNV gain 25503493
dgv965n100 CNV gain 25217958
dgv966n100 CNV gain 25217958
esv3577694 CNV gain 25503493
esv3624413 CNV gain 21293372
esv3624414 CNV gain 21293372
nsv1047382 CNV gain 25217958
nsv518987 CNV loss 19592680
nsv524966 CNV loss 19592680
nsv552060 CNV loss 21841781

Variation tolerance for CALHM2 Gene

Residual Variation Intolerance Score: 58.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.98; 49.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CALHM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CALHM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALHM2 Gene

Disorders for CALHM2 Gene

Relevant External Links for CALHM2

Genetic Association Database (GAD)
CALHM2
Human Genome Epidemiology (HuGE) Navigator
CALHM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CALHM2

No disorders were found for CALHM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CALHM2 Gene

Publications for CALHM2 Gene

  1. A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk. (PMID: 18585350) Dreses-Werringloer U. … Marambaud P. (Cell 2008) 2 3 4 64
  2. Genetic association between CALHM1, 2, and 3 polymorphisms and Alzheimer's disease in a Japanese population. (PMID: 20164573) Shibata N. … Arai H. (J. Alzheimers Dis. 2010) 3 46 64
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64

Products for CALHM2 Gene

Sources for CALHM2 Gene

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