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Aliases for CALHM2 Gene

Aliases for CALHM2 Gene

  • Calcium Homeostasis Modulator 2 2 3 5
  • Family With Sequence Similarity 26, Member B 2 3
  • FAM26B 3 4
  • Calcium Homeostasis Modulator Protein 2 3
  • Protein FAM26B 4

External Ids for CALHM2 Gene

Previous HGNC Symbols for CALHM2 Gene

  • FAM26B

Previous GeneCards Identifiers for CALHM2 Gene

  • GC10M105197
  • GC10M105206
  • GC10M098837

Summaries for CALHM2 Gene

GeneCards Summary for CALHM2 Gene

CALHM2 (Calcium Homeostasis Modulator 2) is a Protein Coding gene. GO annotations related to this gene include cation channel activity. An important paralog of this gene is FAM26F.

UniProtKB/Swiss-Prot for CALHM2 Gene

  • Pore-forming subunit of a voltage-gated ion channel.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALHM2 Gene

Genomics for CALHM2 Gene

Regulatory Elements for CALHM2 Gene

Enhancers for CALHM2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CALHM2 on UCSC Golden Path with GeneCards custom track

Promoters for CALHM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CALHM2 Gene

103,446,785 bp from pter
103,452,405 bp from pter
5,621 bases
Minus strand

Genomic View for CALHM2 Gene

Genes around CALHM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALHM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALHM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALHM2 Gene

Proteins for CALHM2 Gene

  • Protein details for CALHM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcium homeostasis modulator protein 2
    Protein Accession:
    Secondary Accessions:
    • D3DR94
    • O95893
    • Q6ZUV9

    Protein attributes for CALHM2 Gene

    323 amino acids
    Molecular mass:
    36175 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CALHM2 Gene


neXtProt entry for CALHM2 Gene

Post-translational modifications for CALHM2 Gene

No Post-translational modifications

Other Protein References for CALHM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CALHM2 Gene

Domains & Families for CALHM2 Gene

Protein Domains for CALHM2 Gene


Suggested Antigen Peptide Sequences for CALHM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM26 family.
  • Belongs to the FAM26 family.
genes like me logo Genes that share domains with CALHM2: view

No data available for Gene Families for CALHM2 Gene

Function for CALHM2 Gene

Molecular function for CALHM2 Gene

UniProtKB/Swiss-Prot Function:
Pore-forming subunit of a voltage-gated ion channel.

Gene Ontology (GO) - Molecular Function for CALHM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005261 cation channel activity IBA --
genes like me logo Genes that share ontologies with CALHM2: view

Phenotypes for CALHM2 Gene

genes like me logo Genes that share phenotypes with CALHM2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CALHM2

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CALHM2 Gene

Localization for CALHM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALHM2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CALHM2 Gene COMPARTMENTS Subcellular localization image for CALHM2 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for CALHM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
genes like me logo Genes that share ontologies with CALHM2: view

Pathways & Interactions for CALHM2 Gene

SuperPathways for CALHM2 Gene

No Data Available

Interacting Proteins for CALHM2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000260743 Q9HA72-CAHM2_HUMAN for CALHM2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CALHM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034220 ion transmembrane transport IBA --
GO:0098655 cation transmembrane transport IEA --
genes like me logo Genes that share ontologies with CALHM2: view

No data available for Pathways by source and SIGNOR curated interactions for CALHM2 Gene

Drugs & Compounds for CALHM2 Gene

No Compound Related Data Available

Transcripts for CALHM2 Gene

Unigene Clusters for CALHM2 Gene

Calcium homeostasis modulator 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CALHM2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e ^ 7
SP1: - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: -
SP7: - -
SP8: - - - - - - - - -
SP9: - - -
SP10: - - - - - - - - - - -
SP11: - - - -
SP12: - - - - - - -
SP13: - - - - - - -

Relevant External Links for CALHM2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CALHM2 Gene

mRNA expression in normal human tissues for CALHM2 Gene

Protein differential expression in normal tissues from HIPED for CALHM2 Gene

This gene is overexpressed in Uterus (24.7), Pancreas (13.6), and Ovary (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CALHM2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CALHM2 Gene:


SOURCE GeneReport for Unigene cluster for CALHM2 Gene:

genes like me logo Genes that share expression patterns with CALHM2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CALHM2 Gene

Orthologs for CALHM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CALHM2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CALHM2 34
  • 89.78 (n)
  • 90.71 (a)
  • 91 (a)
(Canis familiaris)
Mammalia CALHM2 34
  • 89.78 (n)
  • 91.95 (a)
  • 92 (a)
(Mus musculus)
Mammalia Calhm2 34
  • 87.33 (n)
  • 92.83 (a)
Calhm2 16
Calhm2 35
  • 92 (a)
(Pan troglodytes)
Mammalia CALHM2 34
  • 99.48 (n)
  • 99.38 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Calhm2 34
  • 87.75 (n)
  • 92.83 (a)
(Monodelphis domestica)
Mammalia CALHM2 35
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia CALHM2 35
  • 85 (a)
(Gallus gallus)
Aves CALHM2 34
  • 77.74 (n)
  • 79.62 (a)
  • 80 (a)
(Anolis carolinensis)
Reptilia CALHM2 35
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia calhm2 34
  • 65.83 (n)
  • 69.72 (a)
MGC76165 34
(Danio rerio)
Actinopterygii calhm2 34
  • 60.85 (n)
  • 60.4 (a)
calhm2 35
  • 58 (a)
CALHM2 (2 of 2) 35
  • 52 (a)
(Caenorhabditis elegans)
Secernentea clhm-1 35
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 14 (a)
Species where no ortholog for CALHM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CALHM2 Gene

Gene Tree for CALHM2 (if available)
Gene Tree for CALHM2 (if available)

Paralogs for CALHM2 Gene

Paralogs for CALHM2 Gene

(4) SIMAP similar genes for CALHM2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CALHM2: view

Variants for CALHM2 Gene

Sequence variations from dbSNP and Humsavar for CALHM2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs2232662 - 103,447,544(-) TCGGC(A/G/T)TGGTG nc-transcript-variant, reference, synonymous-codon, missense
rs2232660 - 103,449,535(-) GTTCG(G/T)GGACC nc-transcript-variant, reference, missense
rs3837347 -- 103,451,653(-) tcctc(-/CTCCTC)ctgtt intron-variant, upstream-variant-2KB
rs2232658 -- 103,450,224(-) AGTGA(A/G)CAGTG intron-variant, utr-variant-5-prime
rs2232659 -- 103,449,656(-) GCTCC(A/G)CCGCC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CALHM2 Gene

Variant ID Type Subtype PubMed ID
dgv280e212 CNV gain 25503493
dgv965n100 CNV gain 25217958
dgv966n100 CNV gain 25217958
esv3577694 CNV gain 25503493
esv3624413 CNV gain 21293372
esv3624414 CNV gain 21293372
nsv1047382 CNV gain 25217958
nsv518987 CNV loss 19592680
nsv524966 CNV loss 19592680
nsv552060 CNV loss 21841781

Variation tolerance for CALHM2 Gene

Residual Variation Intolerance Score: 58.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.98; 49.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CALHM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALHM2 Gene

Disorders for CALHM2 Gene

Relevant External Links for CALHM2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CALHM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CALHM2 Gene

Publications for CALHM2 Gene

  1. A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk. (PMID: 18585350) Dreses-Werringloer U. … Marambaud P. (Cell 2008) 2 3 4 65
  2. Genetic association between CALHM1, 2, and 3 polymorphisms and Alzheimer's disease in a Japanese population. (PMID: 20164573) Shibata N. … Arai H. (J. Alzheimers Dis. 2010) 3 46 65
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 65

Products for CALHM2 Gene

Sources for CALHM2 Gene

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