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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CALHM2 Gene

protein-coding   GIFtS: 46
GCID: GC10M105206

Calcium Homeostasis Modulator 2

(Previous names: family with sequence similarity 26, member B)
(Previous symbol: FAM26B)
Alzheimer's & Parkinson's Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Calcium Homeostasis Modulator 21 2
FAM26B1 2 3 5
Family With Sequence Similarity 26, Member B1 2
Calcium Homeostasis Modulator Protein 22
Protein FAM26B3

External Ids:    HGNC: 234931   Entrez Gene: 510632   Ensembl: ENSG000001381727   OMIM: 6122355   UniProtKB: Q9HA723   
ORGUL members:         
NONCODE14:n407058      

Export aliases for CALHM2 gene to outside databases

Previous GC identifers: GC10M105197 GC10M098837


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CALHM2 Gene: 
CALHM2 (calcium homeostasis modulator 2) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with CALHM2 include alzheimer's disease. An important paralog of this gene is CALHM1.

UniProtKB/Swiss-Prot: CAHM2_HUMAN, Q9HA72
Function: Pore-forming subunit of a voltage-gated ion channel (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CALHM2 gene promoter:
         AhR   GR   Pax-5   GR-beta   Pax-2   LCR-F1   YY1   GATA-2   HEN1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCALHM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CALHM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CALHM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.33   Ensembl cytogenetic band:  10q24.33   HGNC cytogenetic band: 10q24.33

CALHM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALHM2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M105206:  view genomic region     (about GC identifiers)

Start:
105,206,543 bp from pter      End:
105,212,660 bp from pter
Size:
6,118 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CAHM2_HUMAN, Q9HA72 (See protein sequence)
Recommended Name: Calcium homeostasis modulator protein 2  
Size: 323 amino acids; 36175 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: D3DR94 O95893 Q6ZUV9
Alternative splicing: 3 isoforms:  Q9HA72-1   Q9HA72-2   Q9HA72-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CALHM2: NX_Q9HA72

Explore proteomics data for CALHM2 at MOPED 

CALHM2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

CALHM2 Protein Expression

REFSEQ proteins: NP_057000.2  
ENSEMBL proteins: 
 ENSP00000358803   ENSP00000260743   ENSP00000376927  

Human Recombinant Protein Products for CALHM2: 
Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for CALHM2
OriGene Protein Over-expression Lysate for CALHM2
OriGene MassSpec for CALHM2 
OriGene Custom Protein Services for CALHM2
GenScript Custom Purified and Recombinant Proteins Services for CALHM2
Novus Biologicals CALHM2 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for CALHM2 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral to membrane IEA--

CALHM2 for ontologies           About GeneDecksing



CALHM2 Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for CALHM2
GenScript Custom Superior Antibodies Services for CALHM2
Novus Biologicals CALHM2 Antibody
Abcam antibodies for CALHM2
Cloud-Clone Corp. Antibodies for CALHM2 
Search ThermoFisher Antibodies for CALHM2
Search LSBio for Antibodies for CALHM2 

Assay Products for CALHM2: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for CALHM2
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for CALHM2
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for CALHM2 
Cloud-Clone Corp. CLIAs for CALHM2


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q9HA72

UniProtKB/Swiss-Prot: CAHM2_HUMAN, Q9HA72
Similarity: Belongs to the FAM26 family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: CAHM2_HUMAN, Q9HA72
Function: Pore-forming subunit of a voltage-gated ion channel (By similarity)

Animal Models:

   inGenious Targeting Laboratory - Custom generated mouse model solutions for CALHM2 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CALHM2

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CALHM2 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CALHM2 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALHM2
2 QIAGEN miScript miRNA Assays for microRNAs that regulate CALHM2:
hsa-miR-374a* hsa-miR-3163
SwitchGear 3'UTR luciferase reporter plasmidCALHM2 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for CALHM2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALHM2

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for CALHM2
Sirion Biotech Customized adenovirus for overexpression of CALHM2

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for CALHM2 (see all 7)
OriGene ORF clones in mouse, rat for CALHM2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CALHM2 (NM_015916)
Sino Biological Human cDNA Clone for CALHM2
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALHM2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALHM2
Sirion Biotech Customized lentivirus for stable overexpression of CALHM2 
                     Customized lentivirus expression plasmids for stable overexpression of CALHM2 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for CALHM2
Search LifeMap BioReagents cell lines for CALHM2
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALHM2


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section




Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CALHM2

2 Interacting proteins for CALHM2 (Q9HA723) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
MAPK3P273613I2D: score=1 
PLSCR1O151623I2D: score=1 
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006811ion transport IEA--

CALHM2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CALHM2 (CAHM2)

Search CenterWatch for drugs/clinical trials and news about CALHM2 / CAHM2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CALHM2 gene: 
NM_015916.4  

Unigene Cluster for CALHM2:

Calcium homeostasis modulator 2
Hs.241545  [show with all ESTs]
Unigene Representative Sequence: AK125276
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000369788(uc001kxc.3 uc001kxb.3) ENST00000260743(uc001kxa.3)
ENST00000494180 ENST00000463878 ENST00000480642 ENST00000461631 ENST00000474797
ENST00000393235(uc001kxd.1)

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALHM2
2 QIAGEN miScript miRNA Assays for microRNAs that regulate CALHM2:
hsa-miR-374a* hsa-miR-3163
SwitchGear 3'UTR luciferase reporter plasmidCALHM2 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for CALHM2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALHM2
Clone
Products:
     
OriGene clones in human, mouse for CALHM2 (see all 7)
OriGene ORF clones in mouse, rat for CALHM2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CALHM2 (NM_015916)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALHM2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALHM2
Sirion Biotech Customized lentivirus for stable overexpression of CALHM2 
                     Customized lentivirus expression plasmids for stable overexpression of CALHM2 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for CALHM2
OriGene qSTAR qPCR primer pairs in human, mouse for CALHM2
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CALHM2
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALHM2
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALHM2

Additional mRNA sequence: 

AF131810.1 AK022195.1 AK125276.1 BC000039.2 NR_024552.1 NR_046344.1 

11 DOTS entries:

DT.315666  DT.95284754  DT.101958092  DT.91752949  DT.121299076  DT.100784236  DT.100784240  DT.91666285 
DT.95170314  DT.97844790  DT.203101 

24/176 AceView cDNA sequences (see all 176):

BU625595 AK125276 BE218764 CD365394 BM551755 CR614833 AF131810 AL602592 
AI005028 CF265181 BQ029260 CD627317 AI697515 CF272443 BQ005206 BE904641 
NM_015916 BM693426 AU098407 CA432041 BG697889 AI247576 BP377505 BP380146 

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for CALHM2 (see all 13)    About this scheme

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e ^ 7
SP1:              -     -     -     -     -                 -     -                 -     -     -                                                               
SP2:                                                        -     -     -           -     -     -     -     -     -     -                                       
SP3:                                                        -                       -     -     -     -     -     -     -                                       
SP4:                                                        -     -     -           -     -     -     -     -     -     -                             -         
SP5:              -     -     -     -     -     -     -     -     -     -                                                                                       


ECgene alternative splicing isoforms for CALHM2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CALHM2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TATCTAGCTG
CALHM2 Expression
About this image


See CALHM2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CALHM2

SOURCE GeneReport for Unigene cluster: Hs.241545
    SABiosciences Custom PCR Arrays for CALHM2
Primer
Products:
OriGene qPCR primer pairs and template standards for CALHM2
OriGene qSTAR qPCR primer pairs in human, mouse for CALHM2
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CALHM2
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALHM2
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALHM2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALHM2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CALHM2 gene from 6/13 species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Calhm21 , 5 calcium homeostasis modulator 21, 5 87.33(n)1
92.83(a)1
  19 (39.28 cM)5
726911  NM_133746.51  NP_598507.31 
 471053535 
chicken
(Gallus gallus)
Aves CALHM21 calcium homeostasis modulator 2 77.85(n)
79.62(a)
  770753  XM_001234075.2  XP_001234076.1 
lizard
(Anolis carolinensis)
Reptilia CALHM26
Uncharacterized protein
73(a)
1 ↔ 1
3(40697056-40700518)
tropical clawed frog
(Xenopus tropicalis)
Amphibia MGC761652 hypothetical protein MGC76165 74.27(n)    BC063213.1 
zebrafish
(Danio rerio)
Actinopterygii calhm21 calcium homeostasis modulator 2 60.85(n)
60.4(a)
  368657  NM_001003458.1  NP_001003458.1 
worm
(Caenorhabditis elegans)
Secernentea clhm-16
Protein CLHM-1
21(a)
1 → many
II(6868942-6870839)


ENSEMBL Gene Tree for CALHM2 (if available)
TreeFam Gene Tree for CALHM2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CALHM2 gene
CALHM12  CALHM32  FAM26D2  FAM26F2  FAM26E2  
4 SIMAP similar genes for CALHM2 using alignment to 1 protein entry:     CAHM2_HUMAN:
FAM26D    CALHM1    CALHM3    FAM26F

CALHM2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/134 SNPs in CALHM2 are shown (see all 134)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 10 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1403594331,2
--105206551(+) TTTTAA/GTAAGA 3 -- ut31 nc-transcript-variant0--------
rs1847155481,2
--105206633(+) CACTGC/TTGCGC 3 -- ut31 nc-transcript-variant0--------
rs65801,2
C,F,O,A,H--105206874(+) CCAAGC/TAGTGC 3 -- ut31 nc-transcript-variantese325Minor allele frequency- N:0.00MN EA NA NS CSA WA EU 3327
rs2014272431,2
C--105206948(+) GGGGCC/TGCGCC 4 A syn10--------
rs617449461,2
F--105207094(+) AATCAC/GTTCCT 4 L V mis11Minor allele frequency- G:0.44NS 18
rs2004583231,2
--105207101(+) TCCTCA/GTCATC 4 D syn10--------
rs22326631,2
C,F,A,H--105207176(-) ACGGCC/TGAGGT 4 A syn1 ese318Minor allele frequency- T:0.09NS EA NA CSA WA EU 7259
rs1998349451,2
--105207183(+) CCGTGC/TGCTGG 4 H R mis10--------
rs1439536191,2
C,F--105207194(+) AACAGC/TTGGTC 4 Q syn12Minor allele frequency- T:0.00NA EU 5875
rs1996969921,2
C--105207196(+) CAGCTA/GGTCCT 4 Q * stg10--------

HapMap Linkage Disequilibrium report for CALHM2 (105206543 - 105212660 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for CALHM2:    About this table     
Variant IDTypeSubtypePubMed ID
nsv524966CNV Loss19592680
nsv518987CNV Loss19592680

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing CALHM2
DNA2.0 Custom Variant and Variant Library Synthesis for CALHM2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 612235    OMIM disorders: --

2 diseases for CALHM2:    About MalaCards
alzheimer's disease    


CALHM2 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
Genetic Association Database (GAD): CALHM2
Human Genome Epidemiology (HuGE) Navigator: CALHM2 (2 documents)

Export disorders for CALHM2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CALHM2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CALHM2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk. (PubMed id 18585350)1, 2, 3 Dreses-Werringloer U....Marambaud P. (2008)
  2. Genetic Association Between CALHM1, 2, and 3 Polymorp hisms and Alzheimer's Disease in a Japanese Population. (PubMed id 20164573)1, 4 Shibata N....Arai H. (2010)
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  6. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
  7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  9. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (1997)
  10. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1 Andersson B.... Gibbs R.A. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 51063 HGNC: 23493 AceView: FAM26B Ensembl:ENSG00000138172 euGenes: HUgn51063
ECgene: CALHM2 H-InvDB: CALHM2

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CALHM2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for CALHM2 gene:
Search GeneIP for patents involving CALHM2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
 EMD Millipore Custom Antibody & Bulk Services
 EMD Millipore Preclinical / Clinical Development Services
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 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CALHM2  
 OriGene qPCR primer pairs and template standards for CALHM2   OriGene Protein Over-expression Lysate for CALHM2  
 OriGene MassSpec something-or-other for CALHM2   OriGene clones in human, mouse for CALHM2  
 OriGene qSTAR qPCR primer pairs in human, mouse for CALHM2   OriGene Purified Protein for CALHM2  
 OriGene ORF clones in mouse, rat for CALHM2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for CALHM2   OriGene Custom Protein Services for CALHM2  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CALHM2
 QIAGEN SeqTarget long-range PCR primers for resequencing CALHM2
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CALHM2
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CALHM2
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALHM2
 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALHM2
 GenScript Custom Purified and Recombinant Proteins Services for CALHM2 GenScript cDNA clones with any tag delivered in your preferred vector for CALHM2
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 GenScript Custom overexpressing Cell Line Services for CALHM2 CloneReady with Over 120,000 Genes
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 Regulatory tfbs in CALHM2 promoter
 Search Chromatin IP Primers for CALHM2
 RT2 qPCR Primer Assay in human, mouse, rat CALHM2
 Search GNC Networks for CALHM2
 SABiosciences Custom PCR Arrays for CALHM2
 Search Tocris compounds for CALHM2 (CAHM2)
 Browse Sino Biological Proteins and Antibodies
 Browse Sino Biological Cell Lysates
 cDNA Clones for CALHM2
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
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 CALHM2 lysates
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 See all of Abcam's Antibodies, Kits and Proteins for CALHM2
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 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins




 Proteins for CALHM2
 Antibodies for CALHM2
 ELISAs for CALHM2
 CLIAs for CALHM2
 Search LifeMap BioReagents cell lines for CALHM2
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALHM2
 SwitchGear 3'UTR luciferase reporter plasmids for CALHM2
 SwitchGear Promoter luciferase reporter plasmids for CALHM2
 Search ThermoFisher Antibodies for CALHM2
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALHM2
 inGenious Targeting Laboratory - Custom generated mouse model solutions for CALHM2
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CALHM2
Customized:
 lentivirus for stable overexpression of CALHM2
 lentivirus expression plasmids for stable overexpression of CALHM2
 adenovirus for overexpression of CALHM2
 Search LSBio for Antibodies for CALHM2
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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Category
(GIFtS: 73)
transforming growth factor, beta 1
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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