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CALHM1 Gene

protein-coding   GIFtS: 45
GCID: GC10M105213

Calcium Homeostasis Modulator 1

(Previous names: family with sequence similarity 26, member C)
(Previous symbol: FAM26C)
  See CALHM1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calcium Homeostasis Modulator 11 2
FAM26C1 2 3 5
Family With Sequence Similarity 26, Member C1 2
Calcium Homeostasis Modulator Protein 12
Protein FAM26C3

External Ids:    HGNC: 234941   Entrez Gene: 2550222   Ensembl: ENSG000001859337   OMIM: 6122345   UniProtKB: Q8IU993   

Export aliases for CALHM1 gene to outside databases

Previous GC identifers: GC10M105204 GC10M098843


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CALHM1 Gene:
This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A
polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's
disease in some populations, but the pathogenicity of this polymorphism is unclear.(provided by RefSeq, Mar 2010)

GeneCards Summary for CALHM1 Gene:
CALHM1 (calcium homeostasis modulator 1) is a protein-coding gene. Diseases associated with CALHM1 include temporal lobe epilepsy, and alzheimer's disease. GO annotations related to this gene include voltage-gated ion channel activity and identical protein binding. An important paralog of this gene is CALHM3.

UniProtKB/Swiss-Prot: CAHM1_HUMAN, Q8IU99
Function: Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and
umami tastes. Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and
umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate
afferent neural gustatory pathways. Acts both as a voltage-gated and calcium-activated ion channel: mediates
neuronal excitability in response to changes in extracellular Ca(2+) concentration. Has poor ion selectivity and
forms a wide pore (around 14 Angstroms) that mediates permeation of Ca(2+), Na(+) and K(+), as well as permeation
of monovalent anions. Acts as an activator of the ERK1 and ERK2 cascade. Triggers endoplasmic reticulum stress by
reducing the calcium content of the endoplasmic reticulum. May indirectly control amyloid precursor protein (APP)
proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CALHM1 gene promoter:
         GR   Pax-5   GR-beta   HNF-4alpha2   NF-kappaB   LCR-F1   HNF-4alpha1   YY1   HEN1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCALHM1 promoter sequence
   Search Chromatin IP Primers for CALHM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CALHM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.33   Ensembl cytogenetic band:  10q24.33   HGNC cytogenetic band: 10q24.33

CALHM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALHM1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M105213:  view genomic region     (about GC identifiers)

Start:
105,213,144 bp from pter      End:
105,218,648 bp from pter
Size:
5,505 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CAHM1_HUMAN, Q8IU99 (See protein sequence)
Recommended Name: Calcium homeostasis modulator protein 1  
Size: 346 amino acids; 38264 Da
Subunit: Homohexamer
Secondary accessions: Q5W091

Explore the universe of human proteins at neXtProt for CALHM1: NX_Q8IU99

Explore proteomics data for CALHM1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn140

  • See CALHM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001001412.3  
    ENSEMBL proteins: 
     ENSP00000329926  

    CALHM1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CALHM1

     
    Search eBioscience for Proteins for CALHM1 

    CALHM1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CALHM1
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    CALHM1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CALHM1
    Cloud-Clone Corp. CLIAs for CALHM1
    Search eBioscience for ELISAs for CALHM1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q8IU99

    UniProtKB/Swiss-Prot: CAHM1_HUMAN, Q8IU99
    Similarity: Belongs to the FAM26 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAHM1_HUMAN, Q8IU99
    Function: Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and
    umami tastes. Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and
    umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate
    afferent neural gustatory pathways. Acts both as a voltage-gated and calcium-activated ion channel: mediates
    neuronal excitability in response to changes in extracellular Ca(2+) concentration. Has poor ion selectivity and
    forms a wide pore (around 14 Angstroms) that mediates permeation of Ca(2+), Na(+) and K(+), as well as permeation
    of monovalent anions. Acts as an activator of the ERK1 and ERK2 cascade. Triggers endoplasmic reticulum stress by
    reducing the calcium content of the endoplasmic reticulum. May indirectly control amyloid precursor protein (APP)
    proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner
    Enzyme regulation: Inhibited by Gd(3+), Ruthenium Red, and Zn(2+) and partially inhibited by 2-aminoethoxydiphenyl
    borate

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005227calcium activated cation channel activity IDA--
    GO:0005244voltage-gated ion channel activity IDA--
    GO:0005262calcium channel activity IEA--
    GO:0042802identical protein binding IPI18585350
         
    Find genes that share ontologies with CALHM1           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Calhm1):
     nervous system 

    Find genes that share phenotypes with CALHM1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Calhm1tm1Geno for CALHM1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CALHM1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CALHM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CALHM1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CALHM1

    miRNA
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    Block miRNA regulation of human, mouse, rat CALHM1 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate CALHM1:
    hsa-miR-200c hsa-miR-3150b-3p hsa-miR-429 hsa-miR-29a* hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidCALHM1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CALHM1
    Predesigned siRNA for gene silencing in human, mouse, rat CALHM1

    Gene Editing
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    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALHM1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CAHM1_HUMAN, Q8IU99: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass
    membrane protein. Note=Colocalizes with HSPA5 at the endoplasmic reticulum
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane5
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005887integral component of plasma membrane IDA--

    Find genes that share ontologies with CALHM1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CALHM1
    Interactions:

        Search GeneGlobe Interaction Network for CALHM1

    1 Interacting protein for CALHM1 (Q8IU991) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALHM1Q8IU991EBI-1790341,EBI-1790341
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006812cation transport IDA--
    GO:0015867ATP transport ISS--
    GO:0034765regulation of ion transmembrane transport IDA--
    GO:0050913sensory perception of bitter taste ISS--
    GO:0050916sensory perception of sweet taste ISS--

    Find genes that share ontologies with CALHM1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CALHM1 (CAHM1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CALHM1 gene: 
    NM_001001412.3  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000329905(uc001kxe.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CALHM1 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate CALHM1:
    hsa-miR-200c hsa-miR-3150b-3p hsa-miR-429 hsa-miR-29a* hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidCALHM1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CALHM1
    Predesigned siRNA for gene silencing in human, mouse, rat CALHM1
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CALHM1 (NM_001001412)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALHM1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CALHM1
    OriGene qSTAR qPCR primer pairs in human, mouse for CALHM1
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat CALHM1
      QuantiTect SYBR Green Assays in human, mouse, rat CALHM1
      QuantiFast Probe-based Assays in human, mouse, rat CALHM1

    5 AceView cDNA sequences:

    NM_001001412 BC036193 BC036208 BI546641 BI546543 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CALHM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTCCATCCT
    CALHM1 Expression
    About this image

    CALHM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CALHM1 Protein Expression

    UniProtKB/Swiss-Prot: CAHM1_HUMAN, Q8IU99
    Tissue specificity: Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y
    cells. Specifically expressed in circumvallate taste bud cells

        Custom PCR Arrays for CALHM1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALHM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CALHM1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Calhm11 , 5 calcium homeostasis modulator 11, 5 85.56(n)1
    93.02(a)1
      19 (39.36 cM)5
    5467291  NM_001081271.11  NP_001074740.11 
     471410355 
    chicken
    (Gallus gallus)
    Aves CALHM11 calcium homeostasis modulator 1 74.17(n)
    72.37(a)
      428977  XM_426534.3  XP_426534.2 
    lizard
    (Anolis carolinensis)
    Reptilia CALHM16
    calcium homeostasis modulator 1
    74(a)
    1 ↔ 1
    3(40725917-40729283)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia calhm11 calcium homeostasis modulator 1 66.67(n)
    68.67(a)
      101734555  XM_004916472.1  XP_004916529.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018871271 calcium homeostasis modulator protein 1-like 64.59(n)
    60(a)
      101887127  XM_005160119.1  XP_005160176.1 
    worm
    (Caenorhabditis elegans)
    Secernentea clhm-16
    Protein CLHM-1 (clhm-1) mRNA, complete cds
    16(a)
    1 → many
    II(6868942-6870839) WBGene00016626


    ENSEMBL Gene Tree for CALHM1 (if available)
    TreeFam Gene Tree for CALHM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CALHM1 gene
    CALHM32  FAM26D2  FAM26F2  FAM26E2  CALHM22  
    2 SIMAP similar genes for CALHM1 using alignment to 1 protein entry:     CAHM1_HUMAN:
    CALHM3    CALHM2

    Find genes that share paralogs with CALHM1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    CAHM1_HUMAN, Q8IU99: Leu-86 causes a dysregulation of Ca(2+) homeostasis and amyloid precursor protein (APP) metabolism
    and has been suggested to be a risk factor for the development of Alzheimer disease (PubMed:18585350,
    PubMed:20061624, PubMed:20164592). However, this association with Alzheimer disease could not be confirmed in a
    number of studies performed in different populations (PubMed:19472444, PubMed:19070563, PubMed:19191331,
    PubMed:19191332, PubMed:19545933, PubMed:19655363, PubMed:21378601). According to a meta-analysis study, Leu-86
    is likely not a genetic determinant of Alzheimer disease but may modulate age of onset by interacting with the
    effect of the APOE*4 allele of the APOE gene (PubMed:20847397)


    Selected SNPs for CALHM1 (see all 208)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30141801,2
    C,F,A,H--98843954(+) TTCTTA/CTTATT 1 -- ut31 trp39Minor allele frequency- C:0.21EA NS WA NA CSA 780
    rs1925249591,2
    --98843968(+) ATTATC/TACTTT 1 -- ut310--------
    rs1124771141,2
    C--105213177(+) TCTTCTTA/-TTCTT 1 -- cds11Minor allele frequency- -:0.50CSA 2
    rs1879301171,2
    --105574787(+) ACCAAA/GTTCTG 1 -- ds50010--------
    rs744615401,2
    F--105574951(+) TCTTTA/CTTCTT 1 -- ut312Minor allele frequency- C:0.04WA NA 238
    rs106474141,2
    C--105574960(+) TCTTC-/TTATTCTT 1 -- cds1 trp30--------
    rs1826448571,2
    --105575262(+) CCTCCA/GGGCCT 1 -- ut310--------
    rs1394345161,2
    C--105575553(+) GAGGGC/TGGTGC 1 -- ut310--------
    rs111916921,2
    C,F,H--105575554(+) AGGGCG/AGTGCT 1 -- ut3120Minor allele frequency- A:0.27NA NS EA 2364
    rs1881137401,2
    --105575601(+) AGATGC/GAAGCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CALHM1 (105213144 - 105218648 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CALHM1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv524966CNV Loss19592680
    nsv437692CNV Loss16327808
    nsv518987CNV Loss19592680

    Human Gene Mutation Database (HGMD): CALHM1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CALHM1
    DNA2.0 Custom Variant and Variant Library Synthesis for CALHM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612234   
    OMIM disorders: 605526  
    2 diseases for CALHM1:    
    About MalaCards
    temporal lobe epilepsy    alzheimer's disease

    1 disease from the University of Copenhagen DISEASES database for CALHM1:
    Alzheimer's disease

    Find genes that share disorders with CALHM1           About GenesLikeMe

    Genetic Association Database (GAD): CALHM1
    Human Genome Epidemiology (HuGE) Navigator: CALHM1 (16 documents)

    Export disorders for CALHM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CALHM1 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with CALHM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CALHM1 variant is not associated with Alzheimer's disease among Asians. (PubMed id 19545933)1, 2, 4 Tan E.K....Zhao Y. (Neurobiol. Aging 2011)
    2. CALHM1 P86L polymorphism is a risk factor for Alzheimer's disease in the Chinese population. (PubMed id 20061624)1, 2, 4 Cui P.J.... Chen S.D. (J. Alzheimers Dis. 2010)
    3. The P86L common allele of CALHM1 does not influence risk for Alzheimer disease in Japanese cohorts. (PubMed id 19655363)1, 2, 4 Inoue K.... Goto Y. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    4. No association between CALHM1 variation and risk of Alzheimer disease. (PubMed id 19191331)1, 2, 4 Minster R.L.... Kamboh M.I. (Hum. Mutat. 2009)
    5. CALHM1 polymorphism is not associated with late-onset Alzheimer disease. (PubMed id 19472444)1, 2, 4 Beecham G.W.... Pericak-Vance M.A. (Ann. Hum. Genet. 2009)
    6. No association between CALHM1 and risk for Alzheimer dementia in a Belgian population. (PubMed id 19191332)1, 2, 4 Sleegers K.... Van Broeckhoven C. (Hum. Mutat. 2009)
    7. A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk. (PubMed id 18585350)1, 2, 3 Dreses-Werringloer U....Marambaud P. (Cell 2008)
    8. Structural and functional similarities of calcium homeostasis modulator 1 (CALHM1) ion channel with connexins, pannexins, and innexins. (PubMed id 23300080)1, 2 Siebert A.P.... Foskett J.K. (J. Biol. Chem. 2013)
    9. CALHM1 controls Ca2+-dependent MEK/ERK/RSK/MSK signaling in neurons. (PubMed id 23345406)1, 2 Dreses-Werringloer U.... Marambaud P. (J. Cell Sci. 2013)
    10. No association between CALHM1 polymorphism and Alzheimer's disease risk in a Hungarian population. (PubMed id 21378601)1, 2 Feher A.... Janka Z. (Psychiatr. Genet. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 255022 HGNC: 23494 AceView: FAM26C Ensembl:ENSG00000185933 euGenes: HUgn255022
    ECgene: CALHM1 H-InvDB: CALHM1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CALHM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for CALHM1 gene:
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