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CALD1 Gene

protein-coding   GIFtS: 66
GCID: GC07P134429

Caldesmon 1

  See CALD1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Caldesmon 11 2     LCAD2
CDM2 3 5     NAG222
H-CAD2     caldesmon2
HCAD2     CAD3
L-CAD2     

External Ids:    HGNC: 14411   Entrez Gene: 8002   Ensembl: ENSG000001227867   OMIM: 1142135   UniProtKB: Q056823   

Export aliases for CALD1 gene to outside databases

Previous GC identifers: GC07P132807 GC07P133866 GC07P133880 GC07P133921 GC07P134114 GC07P128770


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CALD1 Gene:
This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth
muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to
Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the
actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of
smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding
distinct isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for CALD1 Gene:
CALD1 (caldesmon 1) is a protein-coding gene. Diseases associated with CALD1 include breast leiomyosarcoma, and mixed endometrial stromal and smooth muscle tumor. GO annotations related to this gene include actin binding and myosin binding.

UniProtKB/Swiss-Prot: CALD1_HUMAN, Q05682
Function: Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth
muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding
of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the
actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated
by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an
essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral
nerve regeneration (By similarity)

Gene Wiki entry for CALD1 (Caldesmon) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CALD1 gene promoter:
         GR   Nkx2-2   GR-beta   Evi-1   Gfi-1   AREB6   SRY   Sox9   GR-alpha   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 8): CALD1 promoter sequence
   Search Chromatin IP Primers for CALD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CALD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q33   Ensembl cytogenetic band:  7q33   HGNC cytogenetic band: 7q33

CALD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALD1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P134429:  view genomic region     (about GC identifiers)

Start:
134,429,003 bp from pter      End:
134,655,480 bp from pter
Size:
226,478 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 133,808,491-133,999,799     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CALD1_HUMAN, Q05682 (See protein sequence)
Recommended Name: Caldesmon  
Size: 793 amino acids; 93231 Da
Secondary accessions: A8K0X1 Q13978 Q13979 Q14741 Q14742 Q9UD91
Alternative splicing: 6 isoforms:  Q05682-1   Q05682-2   Q05682-3   Q05682-4   Q05682-5   Q05682-6   (No experimental confirmation available. Contains a phosphoserine at position 202)

Explore the universe of human proteins at neXtProt for CALD1: NX_Q05682

Explore proteomics data for CALD1 at MOPED

Post-translational modifications: 

  • In non-muscle cells, phosphorylation by CDK1 during mitosis causes caldesmon to dissociate from microfilaments.
    Phosphorylation reduces caldesmon binding to actin, myosin, and calmodulin as well as its inhibition of
    actomyosin ATPase activity. Phosphorylation also occurs in both quiescent and dividing smooth muscle cells with
    similar effects on the interaction with actin and calmodulin and on microfilaments reorganization. CDK1-mediated
    phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CALD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_004333.1  NP_149129.2  NP_149130.1  NP_149131.1  NP_149347.2  

    ENSEMBL proteins: 
     ENSP00000398826   ENSP00000411476   ENSP00000395710   ENSP00000401988   ENSP00000394715  
     ENSP00000354826   ENSP00000354513   ENSP00000390926   ENSP00000416611   ENSP00000407522  
     ENSP00000393621   ENSP00000419673   ENSP00000355000   ENSP00000376826   ENSP00000445641  
    Reactome Protein details: Q05682

    CALD1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CALD1
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for CALD1
    OriGene Custom Protein Services for CALD1
    GenScript Custom Purified and Recombinant Proteins Services for CALD1
    Novus Biologicals CALD1 Protein
    Novus Biologicals CALD1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CALD1 

    CALD1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CALD1
    R&D Systems Antibodies for CALD1 (Caldesmon/CALD1)
    Cell Signaling Technology (CST) Antibodies for CALD1  (caldesmon)
    OriGene Antibodies for CALD1
    OriGene Custom Antibody Services for CALD1
    Novus Biologicals CALD1 Antibodies
    Abcam antibodies for CALD1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for CALD1
    LSBio Antibodies in human, mouse, rat for CALD1

    CALD1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CALD1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CALD1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CALD1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR006018 Caldesmon_LSP
     IPR006017 Caldesmon

    Graphical View of Domain Structure for InterPro Entry Q05682

    ProtoNet protein and cluster: Q05682

    1 Blocks protein domain: IPB006017 Caldesmon signature

    UniProtKB/Swiss-Prot: CALD1_HUMAN, Q05682
    Domain: The N-terminal part seems to be a myosin/calmodulin-binding domain, and the C-terminal a
    tropomyosin/actin/calmodulin-binding domain. These two domains are separated by a central helical region in the
    smooth-muscle form
    Similarity: Belongs to the caldesmon family


    Find genes that share domains with CALD1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CALD1_HUMAN, Q05682
    Function: Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth
    muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding
    of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the
    actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated
    by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an
    essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral
    nerve regeneration (By similarity)

         Genatlas biochemistry entry for CALD1:
    F-actin cross linking protein,caldesmon,with two alternatively spliced forms,high molecular weight in smooth
    muscle,low molecular weight in non muscle tissues and cells

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005516calmodulin binding IEA--
    GO:0005523tropomyosin binding TAS1555769
    GO:0017022myosin binding IEA--
         
    Find genes that share ontologies with CALD1           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cald1):
     growth/size/body  mortality/aging  muscle  renal/urinary system 

    Find genes that share phenotypes with CALD1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cald1tm1Claw for CALD1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CALD1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CALD1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CALD1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CALD1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CALD1:
    hsa-mir-122-5p (MIRT023307), hsa-mir-149-5p (MIRT045412), hsa-mir-15a-5p (MIRT051318), hsa-mir-21-5p (MIRT030858), hsa-mir-34a-5p (MIRT025321)

    Block miRNA regulation of human, mouse, rat CALD1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CALD1 (see all 73):
    hsa-miR-3146 hsa-miR-106a hsa-miR-199a-3p hsa-miR-30d hsa-miR-374a hsa-miR-138-2* hsa-miR-519a hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmidCALD1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CALD1
    Predesigned siRNA for gene silencing in human, mouse, rat CALD1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CALD1

    Clone
    Products:
         
    OriGene clones in human, mouse for CALD1 (see all 27)
    OriGene ORF clones in mouse, rat for CALD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): CALD1 (NM_004342)
    Sino Biological Human cDNA Clone for CALD1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALD1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CALD1
    Browse ESI BIO Cell Lines and PureStem Progenitors for CALD1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALD1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CALD1_HUMAN, Q05682: Cytoplasm, cytoskeleton (By similarity). Cytoplasm, myofibril (By similarity). Note=On thin
    filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle) (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol4
    plasma membrane4
    nucleus3
    extracellular2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton TAS16130169
    GO:0005886plasma membrane IDA--
    GO:0015629actin cytoskeleton IDA--
    GO:0016020membrane ----

    Find genes that share ontologies with CALD1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CALD1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Striated Muscle Contraction
    Muscle contraction0.61
    Smooth Muscle Contraction0.47
    2Development Angiotensin activation of ERK
    Development ACM2 and ACM4 activation of ERK0.74
    3Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43
    4Integrin Pathway
    Transendothelial Migration of Leukocytes0.38
    5Oxytocin signaling pathway
    Vascular smooth muscle contraction0.32


    Find genes that share SuperPaths with CALD1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CALD1
        Transendothelial Migration of Leukocytes

    1 Cell Signaling Technology (CST) Pathway for CALD1
        Cytoskeletal Signaling

    1 GeneGo (Thomson Reuters) Pathway for CALD1
        Development ACM2 and ACM4 activation of ERK

    1 BioSystems Pathway for CALD1
        Myometrial Relaxation and Contraction Pathways


    1 Reactome Pathway for CALD1
        Smooth Muscle Contraction


    1 Kegg Pathway  (Kegg details for CALD1):
        Vascular smooth muscle contraction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CALD1: 
              Cytoskeleton Regulators in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CALD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CALD1 (Q056823 ENSP000003548264) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=6 STRING: ENSP00000349467
    CALM2P621583I2D: score=6 
    CALM3P621583I2D: score=6 
    SHC1P293533, ENSP000004013034I2D: score=3 STRING: ENSP00000401303
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement TAS16130169
    GO:0006936muscle contraction TAS--

    Find genes that share ontologies with CALD1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CALD1

    1 HMDB Compound for CALD1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 Novoseek inferred chemical compound relationship for CALD1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    actomyosin 59.7 1 1555769 (1)



    Find genes that share compounds with CALD1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CALD1 gene (5 alternative transcripts): 
    NM_004342.6  NM_033138.3  NM_033139.3  NM_033140.3  NM_033157.3  

    Unigene Cluster for CALD1:

    Caldesmon 1
    Hs.490203  [show with all ESTs]
    Unigene Representative Sequence: NM_033138
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000417172 ENST00000436461 ENST00000422748 ENST00000454108 ENST00000475772
    ENST00000430085 ENST00000462181 ENST00000482470(uc003vry.3) ENST00000361675(uc011kpv.2)
    ENST00000361901 ENST00000498254 ENST00000489019 ENST00000445569 ENST00000435928
    ENST00000443197(uc010lmn.3) ENST00000424922 ENST00000495522 ENST00000496024

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CALD1 (see all 73):
    hsa-miR-3146 hsa-miR-106a hsa-miR-199a-3p hsa-miR-30d hsa-miR-374a hsa-miR-138-2* hsa-miR-519a hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmidCALD1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CALD1
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): CALD1 (NM_004342)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALD1
    Primer
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    OriGene qPCR primer pairs and template standards for CALD1
    OriGene qSTAR qPCR primer pairs in human, mouse for CALD1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CALD1
      QuantiTect SYBR Green Assays in human, mouse, rat CALD1
      QuantiFast Probe-based Assays in human, mouse, rat CALD1

    Additional mRNA sequence: 

    AB062484.1 AF315788.1 AJ223812.1 AK289686.1 AK298524.1 AK300282.1 AK304729.1 BC005006.1 
    BC014035.2 BC015839.1 BC040354.1 BC061926.1 BX538339.1 BX648808.1 BX649088.1 D90452.1 
    D90453.1 M64110.1 M83216.1 

    Selected DOTS entries (see all 61):

    DT.92363185  DT.92356093  DT.100804334  DT.75179907  DT.100887643  DT.100887640  DT.95144198  DT.91734996 
    DT.121060716  DT.121061155  DT.91718961  DT.95325381  DT.91949878  DT.120376  DT.121060633  DT.121061097 
    DT.91773458  DT.92011164  DT.121061167  DT.121060876  DT.408386  DT.95303419  DT.100887647  DT.100887631 

    2 AceView cDNA sequences:

    BF001035 AI888318 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CALD1 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a ·
    SP1:                                                                                                                                                            
    SP2:                    -           -                 -     -     -                                                                                             
    SP3:                    -           -           -     -     -     -     -                                                                                       
    SP4:                                                                                                        -                                                   
    SP5:                    -           -                 -     -                                                                                                   

    ExUns: 18b ^ 19a · 19b ^ 20a · 20b · 20c
    SP1:        -                           
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for CALD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CALD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTGTGAAT
    CALD1 Expression
    About this image


    CALD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 28) fully expand
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 8 entries
             Vascular Smooth Muscle Cells Aortic Arch Arteries
             Vascular smooth muscle-like cells
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Vascular Smooth Muscle Cells Veins
             Human umbilical vein endothelial cells (HUVEC)
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Vascular Smooth Muscle Cells Splanchnic Mesoderm
     
     Heart (Cardiovascular System)
             Vascular Smooth Muscle Cells Aortic Arch Arteries
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Human embryonic stem cells (family)
    CALD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CALD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.490203

    UniProtKB/Swiss-Prot: CALD1_HUMAN, Q05682
    Tissue specificity: High-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles,
    whereas low-molecular-weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and
    cells. Not expressed in skeletal muscle or heart

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CALD1: 
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              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CALD1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cald15 caldesmon 1   --   6 (15.07 cM) 34598500 
    chicken
    (Gallus gallus)
    Aves CALD16
    caldesmon
    60(a)
    1 ↔ 1
    1(62400842-62587151)
    lizard
    (Anolis carolinensis)
    Reptilia CALD16
    caldesmon 1
    60(a)
    1 ↔ 1
    5(14626513-14710217)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.129792 Transcribed sequence with moderate similarity to protein more 77.66(n)    BX722942.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AI545879.12   -- 78.82(n)   322909  AI545879.1 


    ENSEMBL Gene Tree for CALD1 (if available)
    TreeFam Gene Tree for CALD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CALD1 gene
    2 SIMAP similar genes for CALD1 using alignment to 12 protein entries:     CALD1_HUMAN (see all proteins):
    DKFZp686P03208    DKFZp779D0769

    Find genes that share paralogs with CALD1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CALD1
    PGOHUM00000233576


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CALD1 (see all 3537)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1453335951,2
    C--128790547(+) TCTAA-/TTTTTTT 3 -- int10--------
    rs350278601,2
    C--128795112(+) TTTTTT/-AATTA 3 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs1431141391,2
    C--128799145(+) AGTTA-/TTGTT 
            
    TTATT
    3 -- int10--------
    rs113692431,2
    C--128806738(+) ACAAA-/ACAAAC 3 -- int10--------
    rs614595861,2
    C--128868356(+) ATAAA-/GGGTAAT 3 -- int11Minor allele frequency- GG:0.00NA 2
    rs38396771,2
    C--128954648(+) GAACTG/-AGTTT 5 -- int11Minor allele frequency- -:0.00NA 2
    rs2020303301,2
    --133830867(+) GCTAA-/ATT   
       CGTGT
    ATTTT
    3 -- int10--------
    rs1433154921,2
    C--133830868(+) CTAAA-/TTC   
      GTGTAT
    TTTTT
    3 -- int10--------
    rs669177791,2
    C--133830876(+) CTAAATTCGT   
      GTAT
    /-
    TTTTT
    6 -- int1 cds11Minor allele frequency- -:0.50NA 2
    rs671718841,2
    C--133831193(+) TGTAG-/TATATAT 3 -- int10--------

    HapMap Linkage Disequilibrium report for CALD1 (134429003 - 134655480 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CALD1 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2668646CNV Deletion23128226
    esv2677689CNV Deletion23128226
    esv4039CNV Deletion18987735
    esv2735183CNV Deletion23290073
    esv2735182CNV Deletion23290073
    nsv5959CNV Insertion18451855
    nsv521781CNV Loss19592680
    nsv365920CNV Loss16902084
    nsv516148CNV Loss19592680
    esv29739CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CALD1
    DNA2.0 Custom Variant and Variant Library Synthesis for CALD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 114213    OMIM disorders: --

    9 diseases for CALD1:    
    About MalaCards
    breast leiomyosarcoma    mixed endometrial stromal and smooth muscle tumor    kidney leiomyosarcoma    myofibroma
    vulvar leiomyoma    endometrial stromal nodule    pseudosarcomatous fibromatosis    atypical polypoid adenomyoma
    vascular cancer

    14 diseases from the University of Copenhagen DISEASES database for CALD1:
    Leiomyosarcoma     Leiomyoma     Endometrial stromal sarcoma     Smooth muscle tumor
    Vascular cancer     Myofibroma     Mixed endometrial stromal and smooth muscle tumor     Kidney leiomyosarcoma
    Pseudosarcomatous fibromatosis     Hemangiopericytoma     Vulvar leiomyoma     Sarcoma
    Breast leiomyosarcoma     Endometrial stromal nodule

    Find genes that share disorders with CALD1           About GenesLikeMe

    Genetic Association Database (GAD): CALD1
    Human Genome Epidemiology (HuGE) Navigator: CALD1 (3 documents)

    Export disorders for CALD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CALD1 gene, integrated from 10 sources (see all 81):
    (articles sorted by number of sources associating them with CALD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of cDNA clones encoding a human fibroblast caldesmon isoform and analysis of caldesmon expression in normal and transformed cells. (PubMed id 1885618)1, 2, 3 Novy R.E.... Lin J.J.-C. (J. Biol. Chem. 1991)
    2. Genomic structure of the human caldesmon gene. (PubMed id 1465449)1, 2, 9 Hayashi K.... Sobue K. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    3. Cloning of cDNAs encoding human caldesmons. (PubMed id 1555769)1, 2, 9 Humphrey M.B.... Bryan J. (Gene 1992)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Association between variation in the actin-binding gene caldesmon and diabetic nephropathy in type 1 diabetes. (PubMed id 15047636)1, 4 Conway B.R....Fogarty D.G. (Diabetes 2004)
    9. Differential effects of caldesmon on the intermediate conformational states of polymerizing actin. (PubMed id 19889635)1, 9 Huang R....Wang C.L. (J. Biol. Chem. 2010)
    10. Regulation of microfilament organization by Kaposi sarcoma-associated herpes virus-cyclin.CDK6 phosphorylation of caldesmon. (PubMed id 16115893)1, 9 Cuomo M.E....Mittnacht S. (J. Biol. Chem. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 800 HGNC: 1441 AceView: CALD1.3 Ensembl:ENSG00000122786 euGenes: HUgn800
    ECgene: CALD1 Kegg: 800 H-InvDB: CALD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CALD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CALD1 gene:
    Search GeneIP for patents involving CALD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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