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Aliases for CALD1 Gene

Aliases for CALD1 Gene

  • Caldesmon 1 2 3 5
  • CDM 3 4
  • Testis Secretory Sperm-Binding Protein Li 227n 3
  • H-CAD 3
  • L-CAD 3
  • NAG22 3
  • LCAD 3
  • HCAD 3
  • CAD 4

External Ids for CALD1 Gene

Previous GeneCards Identifiers for CALD1 Gene

  • GC07P132807
  • GC07P133866
  • GC07P133880
  • GC07P133921
  • GC07P134114
  • GC07P134429
  • GC07P128770

Summaries for CALD1 Gene

Entrez Gene Summary for CALD1 Gene

  • This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for CALD1 Gene

CALD1 (Caldesmon 1) is a Protein Coding gene. Diseases associated with CALD1 include Kidney Leiomyosarcoma and Inflammatory Leiomyosarcoma. Among its related pathways are Smooth Muscle Contraction and Integrin Pathway. GO annotations related to this gene include actin binding and myosin binding.

UniProtKB/Swiss-Prot for CALD1 Gene

  • Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity).

Gene Wiki entry for CALD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALD1 Gene

Genomics for CALD1 Gene

Regulatory Elements for CALD1 Gene

Enhancers for CALD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CALD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CALD1 Gene

Chromosome:
7
Start:
134,744,252 bp from pter
End:
134,970,729 bp from pter
Size:
226,478 bases
Orientation:
Plus strand

Genomic View for CALD1 Gene

Genes around CALD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALD1 Gene

Proteins for CALD1 Gene

  • Protein details for CALD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05682-CALD1_HUMAN
    Recommended name:
    Caldesmon
    Protein Accession:
    Q05682
    Secondary Accessions:
    • A8K0X1
    • Q13978
    • Q13979
    • Q14741
    • Q14742
    • Q9UD91

    Protein attributes for CALD1 Gene

    Size:
    793 amino acids
    Molecular mass:
    93231 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CALD1 Gene

neXtProt entry for CALD1 Gene

Proteomics data for CALD1 Gene at MOPED

Post-translational modifications for CALD1 Gene

  • In non-muscle cells, phosphorylation by CDK1 during mitosis causes caldesmon to dissociate from microfilaments. Phosphorylation reduces caldesmon binding to actin, myosin, and calmodulin as well as its inhibition of actomyosin ATPase activity. Phosphorylation also occurs in both quiescent and dividing smooth muscle cells with similar effects on the interaction with actin and calmodulin and on microfilaments reorganization. CDK1-mediated phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for CALD1 (Caldesmon/CALD1)
  • Cell Signaling Technology (CST) Antibodies for CALD1 (Caldesmon)

No data available for DME Specific Peptides for CALD1 Gene

Domains & Families for CALD1 Gene

Protein Domains for CALD1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q05682

UniProtKB/Swiss-Prot:

CALD1_HUMAN :
  • The N-terminal part seems to be a myosin/calmodulin-binding domain, and the C-terminal a tropomyosin/actin/calmodulin-binding domain. These two domains are separated by a central helical region in the smooth-muscle form.
  • Belongs to the caldesmon family.
Domain:
  • The N-terminal part seems to be a myosin/calmodulin-binding domain, and the C-terminal a tropomyosin/actin/calmodulin-binding domain. These two domains are separated by a central helical region in the smooth-muscle form.
Family:
  • Belongs to the caldesmon family.
genes like me logo Genes that share domains with CALD1: view

No data available for Gene Families for CALD1 Gene

Function for CALD1 Gene

Molecular function for CALD1 Gene

GENATLAS Biochemistry:
F-actin cross linking protein,caldesmon,with two alternatively spliced forms,high molecular weight in smooth muscle,low molecular weight in non muscle tissues and cells
UniProtKB/Swiss-Prot Function:
Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity).

Gene Ontology (GO) - Molecular Function for CALD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with CALD1: view

Phenotypes for CALD1 Gene

GenomeRNAi human phenotypes for CALD1:
genes like me logo Genes that share phenotypes with CALD1: view

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CALD1 Gene

Localization for CALD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALD1 Gene

Cytoplasm, cytoskeleton. Cytoplasm, myofibril. Note=On thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CALD1 Gene COMPARTMENTS Subcellular localization image for CALD1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
plasma membrane 5
nucleus 3
extracellular 2

Gene Ontology (GO) - Cellular Components for CALD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005856 cytoskeleton TAS 16130169
GO:0005886 plasma membrane IDA --
GO:0030016 myofibril IEA --
genes like me logo Genes that share ontologies with CALD1: view

Pathways & Interactions for CALD1 Gene

genes like me logo Genes that share pathways with CALD1: view

Pathways by source for CALD1 Gene

1 Cell Signaling Technology pathway for CALD1 Gene
1 BioSystems pathway for CALD1 Gene
2 Reactome pathways for CALD1 Gene
1 KEGG pathway for CALD1 Gene
1 GeneGo (Thomson Reuters) pathway for CALD1 Gene
1 Qiagen pathway for CALD1 Gene

SIGNOR curated interactions for CALD1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for CALD1 Gene

None

Drugs & Compounds for CALD1 Gene

(1) Drugs for CALD1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(1) Additional Compounds for CALD1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CALD1: view

Transcripts for CALD1 Gene

mRNA/cDNA for CALD1 Gene

(8) REFSEQ mRNAs :
(19) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(24) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CALD1 Gene

Caldesmon 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CALD1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a ·
SP1:
SP2: - - - - -
SP3: - - - - - - -
SP4: -
SP5: - - - -
SP6: - - -
SP7: -
SP8: - -
SP9:
SP10:
SP11: -
SP12:

ExUns: 18b ^ 19a · 19b ^ 20a · 20b · 20c
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12:

Relevant External Links for CALD1 Gene

GeneLoc Exon Structure for
CALD1
ECgene alternative splicing isoforms for
CALD1

Expression for CALD1 Gene

mRNA expression in normal human tissues for CALD1 Gene

mRNA differential expression in normal tissues according to GTEx for CALD1 Gene

This gene is overexpressed in Esophagus - Muscularis (x5.4), Artery - Tibial (x4.6), and Colon - Sigmoid (x4.1).

Protein differential expression in normal tissues from HIPED for CALD1 Gene

This gene is overexpressed in Bone marrow stromal cell (11.4), Seminal vesicle (7.6), Colon muscle (7.5), and Urinary Bladder (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CALD1 Gene



SOURCE GeneReport for Unigene cluster for CALD1 Gene Hs.490203

mRNA Expression by UniProt/SwissProt for CALD1 Gene

Q05682-CALD1_HUMAN
Tissue specificity: High-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular-weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart.
genes like me logo Genes that share expression patterns with CALD1: view

Protein tissue co-expression partners for CALD1 Gene

- Elite partner

Primer Products

Orthologs for CALD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CALD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CALD1 35
  • 89.55 (n)
  • 91.59 (a)
CALD1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CALD1 35
  • 85.19 (n)
  • 87.19 (a)
CALD1 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CALD1 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cald1 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CALD1 36
  • 56 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CALD1 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves CALD1 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CALD1 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100124848 35
  • 64.45 (n)
  • 63.57 (a)
Str.12979 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
cald1 36
  • 37 (a)
OneToMany
cald1l 36
  • 54 (a)
OneToMany
Species with no ortholog for CALD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CALD1 Gene

ENSEMBL:
Gene Tree for CALD1 (if available)
TreeFam:
Gene Tree for CALD1 (if available)

Paralogs for CALD1 Gene

Pseudogenes.org Pseudogenes for CALD1 Gene

genes like me logo Genes that share paralogs with CALD1: view

No data available for Paralogs for CALD1 Gene

Variants for CALD1 Gene

Sequence variations from dbSNP and Humsavar for CALD1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_065254 -

Structural Variations from Database of Genomic Variants (DGV) for CALD1 Gene

Variant ID Type Subtype PubMed ID
nsv889223 CNV Gain 21882294
nsv5959 CNV Insertion 18451855
esv2668646 CNV Deletion 23128226
esv29739 CNV Loss 19812545
nsv521781 CNV Loss 19592680
esv2677689 CNV Deletion 23128226
esv2735182 CNV Deletion 23290073
esv4039 CNV Deletion 18987735
nsv365920 CNV Loss 16902084
esv2735183 CNV Deletion 23290073
nsv516148 CNV Loss 19592680
nsv527174 CNV Loss 19592680

Variation tolerance for CALD1 Gene

Residual Variation Intolerance Score: 62.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.02; 60.41% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CALD1 Gene

Disorders for CALD1 Gene

MalaCards: The human disease database

(35) MalaCards diseases for CALD1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
kidney leiomyosarcoma
  • leiomyosarcoma of kidney
inflammatory leiomyosarcoma
gastrointestinal anthrax
breast leiomyosarcoma
  • leiomyosarcoma of the breast
conventional leiomyosarcoma
- elite association - COSMIC cancer census association via MalaCards
Search CALD1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CALD1

Genetic Association Database (GAD)
CALD1
Human Genome Epidemiology (HuGE) Navigator
CALD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CALD1
genes like me logo Genes that share disorders with CALD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CALD1 Gene

Publications for CALD1 Gene

  1. Characterization of cDNA clones encoding a human fibroblast caldesmon isoform and analysis of caldesmon expression in normal and transformed cells. (PMID: 1885618) Novy R.E. … Lin J.J.-C. (J. Biol. Chem. 1991) 2 3 4 67
  2. Differential effects of caldesmon on the intermediate conformational states of polymerizing actin. (PMID: 19889635) Huang R. … Wang C.L. (J. Biol. Chem. 2010) 3 23
  3. Glucocorticoid receptor-mediated expression of caldesmon regulates cell migration via the reorganization of the actin cytoskeleton. (PMID: 18772142) Mayanagi T. … Sobue K. (J. Biol. Chem. 2008) 3 23
  4. The role of caldesmon in the regulation of endothelial cytoskeleton and migration. (PMID: 15521070) Mirzapoiazova T. … Verin A.D. (J. Cell. Physiol. 2005) 3 23
  5. Regulation of microfilament organization by Kaposi sarcoma-associated herpes virus-cyclin.CDK6 phosphorylation of caldesmon. (PMID: 16115893) Cuomo M.E. … Mittnacht S. (J. Biol. Chem. 2005) 3 23

Products for CALD1 Gene

Sources for CALD1 Gene

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