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Aliases for CALCRL Gene

Aliases for CALCRL Gene

  • Calcitonin Receptor Like Receptor 2 3 5
  • Calcitonin Receptor-Like Receptor 3 4
  • CGRP Type 1 Receptor 3 4
  • CGRPR 3 4
  • Calcitonin Receptor-Like 2
  • CRLR 3

External Ids for CALCRL Gene

Previous GeneCards Identifiers for CALCRL Gene

  • GC02M186419
  • GC02M186892
  • GC02M188171
  • GC02M188412
  • GC02M188035
  • GC02M187918
  • GC02M180067

Summaries for CALCRL Gene

GeneCards Summary for CALCRL Gene

CALCRL (Calcitonin Receptor Like Receptor) is a Protein Coding gene. Diseases associated with CALCRL include migraine with or without aura 1 and gastroesophageal junction adenocarcinoma. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and protein transporter activity. An important paralog of this gene is MGC57346-CRHR1.

UniProtKB/Swiss-Prot for CALCRL Gene

  • Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Tocris Summary for CALCRL Gene

  • Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys.

Gene Wiki entry for CALCRL Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALCRL Gene

Genomics for CALCRL Gene

Regulatory Elements for CALCRL Gene

Genomic Location for CALCRL Gene

Chromosome:
2
Start:
187,341,963 bp from pter
End:
187,448,460 bp from pter
Size:
106,498 bases
Orientation:
Minus strand

Genomic View for CALCRL Gene

Genes around CALCRL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALCRL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALCRL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALCRL Gene

Proteins for CALCRL Gene

  • Protein details for CALCRL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16602-CALRL_HUMAN
    Recommended name:
    Calcitonin gene-related peptide type 1 receptor
    Protein Accession:
    Q16602
    Secondary Accessions:
    • A8K6G5
    • A8KAD3
    • Q53S02
    • Q53TS5

    Protein attributes for CALCRL Gene

    Size:
    461 amino acids
    Molecular mass:
    52929 Da
    Quaternary structure:
    • Heterodimer of CALCRL and RAMP3 (By similarity). Heterodimer of CALCRL and RAMP1 or CALCRL and RAMP2.
    SequenceCaution:
    • Sequence=BAF84319.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CALCRL Gene

neXtProt entry for CALCRL Gene

Proteomics data for CALCRL Gene at MOPED

Post-translational modifications for CALCRL Gene

  • Glycosylation at Asn 66, Asn 118, and Asn 123
  • Modification sites at PhosphoSitePlus

Other Protein References for CALCRL Gene

Antibody Products

No data available for DME Specific Peptides for CALCRL Gene

Domains & Families for CALCRL Gene

Gene Families for CALCRL Gene

Suggested Antigen Peptide Sequences for CALCRL Gene

Graphical View of Domain Structure for InterPro Entry

Q16602

UniProtKB/Swiss-Prot:

CALRL_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family.
Family:
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with CALCRL: view

Function for CALCRL Gene

Molecular function for CALCRL Gene

UniProtKB/Swiss-Prot Function:
Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Gene Ontology (GO) - Molecular Function for CALCRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004948 calcitonin receptor activity IEA --
genes like me logo Genes that share ontologies with CALCRL: view
genes like me logo Genes that share phenotypes with CALCRL: view

Animal Models for CALCRL Gene

MGI Knock Outs for CALCRL:

Animal Model Products

CRISPR Products

miRNA for CALCRL Gene

miRTarBase miRNAs that target CALCRL

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CALCRL Gene

Localization for CALCRL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALCRL Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CALCRL Gene COMPARTMENTS Subcellular localization image for CALCRL gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
lysosome 5
plasma membrane 5
vacuole 5
extracellular 1

Gene Ontology (GO) - Cellular Components for CALCRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IDA 10882736
genes like me logo Genes that share ontologies with CALCRL: view

Pathways & Interactions for CALCRL Gene

genes like me logo Genes that share pathways with CALCRL: view

Pathways by source for CALCRL Gene

Gene Ontology (GO) - Biological Process for CALCRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IDA 20596610
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA --
GO:0007507 heart development IEA --
GO:0015031 protein transport IDA 9620797
genes like me logo Genes that share ontologies with CALCRL: view

No data available for SIGNOR curated interactions for CALCRL Gene

Drugs & Compounds for CALCRL Gene

(6) Drugs for CALCRL Gene - From: Novoseek and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CGRP Pharma 0

(8) Additional Compounds for CALCRL Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha-CGRP (human)
90954-53-3
Calcitonin (salmon)
47931-85-1
CGRP (rat)
83651-90-5
PHM 27 (human)
118025-43-7
SUN-B 8155
345893-91-6
genes like me logo Genes that share compounds with CALCRL: view

Transcripts for CALCRL Gene

Unigene Clusters for CALCRL Gene

Calcitonin receptor-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CALCRL Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - -
SP2: - - -
SP3: - - - - - - - -
SP4: -
SP5: - - - - -
SP6: - - - - - - -
SP7: - -
SP8: - - - - - -
SP9: - -
SP10:
SP11: - - - -

Relevant External Links for CALCRL Gene

GeneLoc Exon Structure for
CALCRL
ECgene alternative splicing isoforms for
CALCRL

Expression for CALCRL Gene

mRNA expression in normal human tissues for CALCRL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CALCRL Gene

This gene is overexpressed in Lung (x6.1) and Adipose - Visceral (Omentum) (x4.4).

Protein differential expression in normal tissues from HIPED for CALCRL Gene

This gene is overexpressed in Lung (38.1) and Spinal cord (18.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CALCRL Gene



SOURCE GeneReport for Unigene cluster for CALCRL Gene Hs.470882

mRNA Expression by UniProt/SwissProt for CALCRL Gene

Q16602-CALRL_HUMAN
Tissue specificity: Predominantly expressed in the lung and heart.
genes like me logo Genes that share expression patterns with CALCRL: view

Protein tissue co-expression partners for CALCRL Gene

Primer Products

In Situ Assay Products

Orthologs for CALCRL Gene

This gene was present in the common ancestor of animals.

Orthologs for CALCRL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CALCRL 36
  • 100 (a)
OneToOne
CALCRL 35
  • 99.86 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia CALCRL 35
  • 90.53 (n)
  • 92.41 (a)
CALCRL 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CALCRL 36
  • 94 (a)
OneToOne
CALCRL 35
  • 90.09 (n)
  • 93.71 (a)
mouse
(Mus musculus)
Mammalia Calcrl 16
Calcrl 36
  • 89 (a)
OneToOne
Calcrl 35
  • 85.36 (n)
  • 90.22 (a)
oppossum
(Monodelphis domestica)
Mammalia CALCRL 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CALCRL 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Calcrl 35
  • 86.23 (n)
  • 90.87 (a)
chicken
(Gallus gallus)
Aves CALCRL 35
  • 77.2 (n)
  • 83.3 (a)
CALCRL 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CALCRL 36
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia calcrl-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia calcrl 35
  • 74.55 (n)
  • 84.09 (a)
Str.12334 35
zebrafish
(Danio rerio)
Actinopterygii calcrla 36
  • 70 (a)
OneToMany
calcrlb 36
  • 63 (a)
OneToMany
calcrla 35
  • 69.32 (n)
  • 73.67 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRCAL1 35
  • 49.32 (n)
  • 44.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dh31-R1 36
  • 34 (a)
ManyToMany
hec 36
  • 27 (a)
ManyToMany
Pdfr 36
  • 19 (a)
ManyToMany
EG:BACR25B3.3 37
  • 28 (a)
Dh31-R1 35
  • 50.28 (n)
  • 43.79 (a)
worm
(Caenorhabditis elegans)
Secernentea pdfr-1 36
  • 21 (a)
OneToMany
Species with no ortholog for CALCRL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CALCRL Gene

ENSEMBL:
Gene Tree for CALCRL (if available)
TreeFam:
Gene Tree for CALCRL (if available)

Paralogs for CALCRL Gene

(9) SIMAP similar genes for CALCRL Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CALCRL: view

Variants for CALCRL Gene

Sequence variations from dbSNP and Humsavar for CALCRL Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs13391909 - 187,385,548(+) ACCAT(A/T)AAAAA reference, missense
rs34010553 - 187,359,233(-) TGCTA(G/T)AAGCT reference, missense
rs698577 - 187,385,574(+) AAAAT(A/G/T)CAGGG reference, missense
rs858745 -- 187,352,080(+) CAAAC(C/T)TCTCA intron-variant
rs858746 -- 187,352,702(+) TTTAT(A/G)GAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CALCRL Gene

Variant ID Type Subtype PubMed ID
nsv834487 CNV Gain 17160897
esv2249015 CNV Deletion 18987734
esv3033 CNV Deletion 18987735
esv2721246 CNV Deletion 23290073
esv992040 CNV Deletion 20482838
esv1045156 CNV Deletion 17803354
esv6916 CNV Loss 19470904
dgv4393n71 CNV Loss 21882294
nsv875560 CNV Loss 21882294
dgv4394n71 CNV Loss 21882294
nsv517687 CNV Loss 19592680
dgv4395n71 CNV Loss 21882294
dgv4396n71 CNV Loss 21882294
nsv834488 CNV Gain+Loss 17160897
esv1009899 CNV Deletion 20482838
nsv459989 CNV Loss 19166990

Variation tolerance for CALCRL Gene

Residual Variation Intolerance Score: 35.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CALCRL Gene

HapMap Linkage Disequilibrium report
CALCRL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALCRL Gene

Disorders for CALCRL Gene

MalaCards: The human disease database

(2) MalaCards diseases for CALCRL Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
migraine with or without aura 1
  • migraine
gastroesophageal junction adenocarcinoma
  • adenocarcinoma of cardioesophageal junction
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CALCRL

Genetic Association Database (GAD)
CALCRL
Human Genome Epidemiology (HuGE) Navigator
CALCRL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CALCRL
genes like me logo Genes that share disorders with CALCRL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CALCRL Gene

Publications for CALCRL Gene

  1. A cDNA encoding the calcitonin gene-related peptide type 1 receptor. (PMID: 8626685) Aiyar N. … Li Y. (J. Biol. Chem. 1996) 2 3 4 67
  2. Activation of calcitonin receptor and calcitonin receptor-like receptor by membrane-anchored ligands. (PMID: 19903822) Chang C.L. … Hsu S.Y. (J. Biol. Chem. 2010) 3 23
  3. Mapping interaction sites within the N-terminus of the calcitonin gene-related peptide receptor; the role of residues 23-60 of the calcitonin receptor-like receptor. (PMID: 19913063) Barwell J. … Poyner D.R. (Peptides 2010) 3 23
  4. Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2. (PMID: 20074556) Kuwasako K. … Kato J. (Biochem. Biophys. Res. Commun. 2010) 3 23
  5. Flow cytometric analysis of the calcitonin receptor-like receptor domains responsible for cell-surface translocation of receptor activity-modifying proteins. (PMID: 19394311) Kuwasako K. … Kato J. (Biochem. Biophys. Res. Commun. 2009) 3 23

Products for CALCRL Gene

Sources for CALCRL Gene

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