Aliases for CALCRL Gene
External Ids for CALCRL Gene
Previous GeneCards Identifiers for CALCRL Gene
GeneCards Summary for CALCRL Gene
CALCRL (Calcitonin Receptor Like Receptor) is a Protein Coding gene. Diseases associated with CALCRL include Pheochromocytoma and Migraine With Or Without Aura 1. Among its related pathways are Vascular smooth muscle contraction and Endothelin Pathways. GO annotations related to this gene include G-protein coupled receptor activity and protein transporter activity. An important paralog of this gene is CALCR.
UniProtKB/Swiss-Prot for CALCRL Gene
Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys.