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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CALCRL Gene

protein-coding GIFtS: 62
GCID: GC02M188171

calcitonin receptor-like

Explore 29 diseases affiliated with
CALCRL via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Calcitonin Receptor-Like¹ ²
CGRPR¹ ² ³ ⁵
CRLR¹ ² ⁵
Calcitonin Receptor-Like Receptor² ³
CGRP Type 1 Receptor² ³
Calcitonin Gene-Related Peptide Type 1 Receptor²

External Ids:	HGNC: 16709¹	Entrez Gene: 10203²	Ensembl: ENSG00000064989⁷	OMIM: 114190⁵	UniProtKB: Q16602³

Export aliases for CALCRL gene to outside databases

Previous GC identifers: GC02M186419 GC02M186892 GC02M188412 GC02M188035 GC02M187918 GC02M180067

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CALRL_HUMAN, Q16602

Function: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin

together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is

mediated by G proteins which activate adenylyl cyclase

summary for CALCRL:

Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight

subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The receptors have a wide biological distribution;

high concentrations are found in the brain, lung, liver, heart and spleen with lower expression levels

present in the testes, gastrointestinal tract and thyroid. The main function of CT receptors is to inhibit

bone reabsorption and enhance calcium excretion by the kidneys. AMY receptors are heterodimers of the CT

receptor and receptor activating modifying proteins (RAMP) 1-3, which have been implicated in type II

diabetes pathology. The CALCRL receptor alone is non-functioning, but forms heterodimers with RAMPs to form

the CGRP (CALCRL with RAMP1), AM1 (CALCRL with RAMP2) and AM2 (CALCRL with RAMP3) receptors. Their main

function is inducing vasodilation, which causes hypotension.

Gene Wiki entry for CALCRL

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CALCRL gene promoter:
SRF STAT1 SRF (504 AA) ATF-2 GATA-1 CREB POU2F1 deltaCREB POU2F1a Chx10
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CALCRL promoter sequence

Search SABiosciences Chromatin IP Primers for CALCRL

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CALCRL

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32.1 Ensembl cytogenetic band: 2q32.1 HGNC cytogenetic band: 2q21.1-q21.3

CALCRL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALCRL gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M188171: view genomic region (about GC identifiers)

Start:	188,207,846 bp from pter	End:	188,313,187 bp from pter
Size:	105,342 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CALRL_HUMAN, Q16602 (See protein sequence)

Recommended Name: Calcitonin gene-related peptide type 1 receptor precursor

Size: 461 amino acids; 52929 Da

Subunit: Heterodimer of CALCRL and RAMP3 (By similarity). Heterodimer of CALCRL and RAMP1 or CALCRL and RAMP2

Subcellular location: Cell membrane; Multi-pass membrane protein

Sequence caution: Sequence=BAF84319.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

4 PDB 3D structures from and Proteopedia for CALCRL:

3AQF (3D)

3N7P (3D)

3N7R (3D)

3N7S (3D)

Secondary accessions: A8K6G5 A8KAD3 Q53S02 Q53TS5

Explore the universe of human proteins at neXtProt for CALCRL: NX_Q16602

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q16602

CALCRL Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001258680.1 NP_005786.1

ENSEMBL proteins:

ENSP00000376177 ENSP00000386972 ENSP00000387190 ENSP00000415626 ENSP00000386599

Reactome Protein details: Q16602
Human Recombinant Protein Products for CALCRL:

	EMD Millipore Purified and/or Recombinant CALCRL Protein
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	GenScript Custom Purified and Recombinant Proteins Services for CALCRL
	Novus Biologicals CALCRL Proteins Novus Biologicals CALCRL Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CALCRL

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005764	lysosome	IDA	10882736
GO:0005768	endosome	IDA	10882736
GO:0005783	endoplasmic reticulum	IDA	10882736
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	7818539

CALCRL for ontologies About GeneDecksing

CALCRL Antibody Products:

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	Novus Biologicals CALCRL Antibodies
	Abcam antibodies for CALCRL
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	Search ThermoFisher Antibodies for CALCRL

Assay Products for CALCRL:

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	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CALCRL
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CALCRL

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CALCRL for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR001879 GPCR_2_extracellular_dom

IPR003287 GCPR_2_calcitonin_rcpt_fam

IPR000832 GPCR_2_secretin-like

IPR003289 GPCR_2_CGRP1_rcpt

IPR017983 GPCR_2_secretin-like_CS

Graphical View of Domain Structure for InterPro Entry Q16602

ProtoNet protein and cluster: Q16602

3 Blocks protein families:

IPB000832 G-protein coupled receptors family 2 (secretin-like)

IPB003287 Calcitonin receptor family signature

IPB003289 Calcitonin gene-related peptide type 1 receptor signature

UniProtKB/Swiss-Prot: CALRL_HUMAN, Q16602

Similarity: Belongs to the G-protein coupled receptor 2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CALRL_HUMAN, Q16602

Function: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin

together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is

mediated by G proteins which activate adenylyl cyclase

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001605	adrenomedullin receptor activity	IDA	--
GO:0001635	calcitonin gene-related polypeptide receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	TAS	7818539
GO:0004948	calcitonin receptor activity	IEA	--
GO:0005515	protein binding	IPI	9620797

CALCRL for ontologies About GeneDecksing

Phenotypes:
8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Calcrl):

cardiovascular system	cellular	digestive/alimentary	homeostasis/metabolism	immune system
integument	mortality/aging	muscle

CALCRL for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Calcrl^tm1Kmca for CALCRL

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CALCRL

miRNA Products:		OriGene 3'-UTR Clone: CALCRL Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALCRL
		8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate CALCRL (see all 27):
		hsa-miR-361-5p hsa-miR-448 hsa-miR-513c hsa-miR-371-5p hsa-miR-500a hsa-miR-29b-1* hsa-miR-373* hsa-miR-511

		SwitchGear 3'UTR luciferase reporter plasmid: CALCRL 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CALCRL (see all 7) OriGene shRNA RFP: CALCRL OriGene siRNA: CALCRL
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		Sirion Biotech Custom design and validation of potent shRNA sequences against CALCRL

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CALCRL
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Clone Products:		EMD Millipore Clones for the Expression of CALCRL
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CALCRL (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CALCRL OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CALCRL (NM_005795)
		Sino Biological Human cDNA Clone for CALCRL
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALCRL
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCRL

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CALCRL
		Search LifeMap BioReagents cell lines for CALCRL
		Sirion Biotech Customized stable knockdown cell line services for CALCRL Sirion Biotech Customized inducible knockdown cell line services for CALCRL Sirion Biotech Customized stable overexpressing cell line services for CALCRL Sirion Biotech Customized inducible overexpressing cell line services for CALCRL

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALCRL

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Class A/1 (Rhodopsin-like receptors)

GPCR ligand binding

0.75

Neuroactive ligand-receptor interaction

0.38

G beta:gamma signalling through PLC beta

Class B/2 (Secretin family receptors)

0.20

G alpha (s) signalling events

0.14

Calcitonin-like ligand receptors

Calcitonin-like ligand receptors

1.00

Adenylate cyclase-activating neuropeptides

Adenylate cyclase-activating neuropeptides

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CALCRL

Adenylate cyclase-activating neuropeptides

2 BioSystems Pathways for CALCRL

	Endothelin
	GPCRs, Class B Secretin-like

5/7 Reactome Pathways for CALCRL (see all 7)

	GPCR downstream signaling
	Signal Transduction
	Signaling by GPCR
	Calcitonin-like ligand receptors
	GPCR ligand binding

2 Kegg Pathways (Kegg details for CALCRL):

	Neuroactive ligand-receptor interaction
	Vascular smooth muscle contraction

CALCRL for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CALCRL

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/8 Interacting proteins for CALCRL (Q16602³ ENSP00000376177⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADM	P35318³, ENSP00000278175⁴	I2D: score=1 STRING: ENSP00000278175
CALCA	P01258³, ENSP00000331746⁴	I2D: score=1 STRING: ENSP00000331746
RAMP2	O60895³, ENSP00000253796⁴	I2D: score=1 STRING: ENSP00000253796
RAMP1	O60894³, ENSP00000254661⁴	I2D: score=3 STRING: ENSP00000254661
RAMP3	O60896³, ENSP00000242249⁴	I2D: score=2 STRING: ENSP00000242249

About this table

Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IDA	--
GO:0006171	cAMP biosynthetic process	IDA	--
GO:0006816	calcium ion transport	IDA	10882736
GO:0006937	regulation of muscle contraction	IEA	--
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	7818539

CALCRL for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CALCRL for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for CALCRL available from Tocris Bioscience About this table

Compound	Action	CAS #
CRSP-1	Endogenous central CT receptor agonist	[697327-12-1]
CGRP 8-37 (human)	CGRP1 receptor antagonist	[119911-68-1]
BIBN 4096	Potent and selective CGRP receptor antagonist	[204697-65-4]
CGRP 8-37 (rat)	CGRP1 receptor antagonist	[129121-73-9]
SUN-B 8155	Non-peptide calcitonin (CT) receptor agonist	[345893-91-6]

8 Novoseek chemical compound relationships for CALCRL gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
bibn 4096 bs	90.9	5	12183333 (3), 19914210 (1)
cyclic amp	30.5	2	12630807 (1)
glibenclamide	28.7	1	9428220 (1)
adenylate	27	3	14631146 (1), 9350848 (1), 12196109 (1)
tunicamycin	19.2	2	11389975 (2)
nitric oxide	0	5	9516404 (1), 14717924 (1), 19441274 (1)
potassium	0	1	9877154 (1)
dexamethasone	0	11	10772950 (4), 15358098 (4)

Search CenterWatch for drugs/clinical trials and news about CALCRL / CALRL

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CALCRL gene (2 alternative transcripts):

NM_001271751.1 NM_005795.5

Unigene Clusters for CALCRL:

Calcitonin receptor-like

Hs.470882 [show with all ESTs], Hs.744587 [show with all ESTs]

Unigene Representative Sequences: NM_005795, DQ280491

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000392370(uc002upv.4 uc010frt.3) ENST00000409998 ENST00000410068

ENST00000447403 ENST00000410102 ENST00000474212 ENST00000485973 ENST00000461244

ENST00000479784(uc002upw.2)

miRNA Products:		OriGene 3'-UTR Clone: CALCRL Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CALCRL
		8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate CALCRL (see all 27):
		hsa-miR-361-5p hsa-miR-448 hsa-miR-513c hsa-miR-371-5p hsa-miR-500a hsa-miR-29b-1* hsa-miR-373* hsa-miR-511

		SwitchGear 3'UTR luciferase reporter plasmid: CALCRL 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against CALCRL

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CALCRL (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CALCRL OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CALCRL (NM_005795)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALCRL
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCRL

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALCRL
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALCRL

Additional cDNA sequence: DQ280491.1

9 DOTS entries:

DT.210868 DT.120960866 DT.99949950 DT.120960838 DT.91989109 DT.120960773 DT.120960823 DT.120960762

DT.91742361

24/77 AceView cDNA sequences (see all 77):

BX471114 AA436933 AY389506 NM_005795 AW272754 AA885023 BU677790 N54728

BX646999 AA961493 AI500611 BG570207 Z28783 BQ883932 BU678000 AA757351

CB270158 BG546194 AI741128 BX509212 CB052426 AI478743 AL700314 AI682490

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for CALCRL (see all 11) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	·	7c	^	8a	·	8b	·	8c	^	9	^	10	^	11	^	12	^	13
SP1:							-		-				-				-
SP2:							-						-				-
SP3:							-		-		-		-				-		-		-		-
SP4:													-
SP5:							-		-		-		-				-

ECgene alternative splicing isoforms for CALCRL

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CALCRL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

CALCRL expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Metanephric Mesenchyme

Metanephric Mesenchyme Cells

Kidney

Skeletal Muscle

Hyoid Arch Muscles

Myoblasts

Skeletal Muscle

Mandibular Arch Muscles

Myoblasts

Skeletal Muscle

Kidney

S-shaped Body

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 8 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

Human umbilical vein endothelial cells (HUVEC) (Primary Cell)

Endothelium

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

Fetal cardiomyocytes (20 weeks) (Primary Cell)

Heart, Myocardium

Beating cell clusters (Spontaneous differen...)

HyStem+BMP4-induced MEL2 cells (HyStem+BMP4 inductio...)

Bone

See CALCRL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CALCRL

SOURCE GeneReport for Unigene clusters: Hs.470882 Hs.744587

UniProtKB/Swiss-Prot: CALRL_HUMAN, Q16602

Tissue specificity: Predominantly expressed in the lung and heart

SABiosciences Expression via Pathway-Focused PCR Arrays including CALCRL:

cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat

G Protein Coupled Receptors 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CALCRL Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CALCRL
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CALCRL
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CALCRL

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALCRL

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CALCRL gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CALCRL¹	calcitonin receptor-like	77.3(n) 83.48(a)		423990 NM_001163650.1 NP_001157122.1
lizard (Anolis carolinensis)	Reptilia	CALCRL⁶	--	71(a)	1 ↔ 1	GL343290.1(219300-249259)
African clawed frog (Xenopus laevis)	Amphibia	calcrl-prov²	calcitonin receptor-like	79.64(n)		BC044269.1
zebrafish (Danio rerio)	Actinopterygii	calcrla¹	calcitonin receptor-like a	69.32(n) 73.67(a)		445508 NM_001004010.1 NP_001004010.1
fruit fly (Drosophila melanogaster)	Insecta	EG:BACR25B3.3³ Dh31-R1¹	G-protein coupled receptor protein signaling pathway more³ Diuretic hormone 31 receptor 1¹	28(a)³ 50.38(n)¹ 43.79(a)¹		3A6³ 36475¹ NM_165979.1¹ NP_725278.1¹
worm (Caenorhabditis elegans)	Secernentea	ZK643.3⁶	G-protein coupled receptor ZK643.3	17(a)	possible ortholog	III(8944738-8952870)

ENSEMBL Gene Tree for CALCRL (if available)
TreeFam Gene Tree for CALCRL (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CALCRL gene

GLP1R² GHRHR² GCGR² CALCR² CRHR2² PTH1R² VIPR1² CRHR1²

PTH2R² ADCYAP1R1² SCTR² GLP2R² VIPR2² GIPR²

12 SIMAP similar genes for CALCRL using alignment to 4 protein entries: CALRL_HUMAN (see all proteins):

HCTR-6 CALCR HCTR-5 VIPR1 CRHR2 SCTR

GIPR GCGR GLP1R PTH1R ADCYAP1R1 PTHR2

CALCRL for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs149055460^1,2	C	--	188206360(+)	`TATTG-/ATATATA`	2	--	ds500¹		0	--	--	--	--
rs3079484^1,2	C	--	188206374(+)	`TATATAT/-CAATA`	2	--	ds500¹		1		CSA	2
rs115828358^1,2	F	--	188206448(+)	`TACACA/GTGGCC`	2	--	ds500¹		1		WA	118
rs116219269^1,2	F	--	188206509(+)	`AGGTAC/TCATTT`	2	--	ds500¹		1		WA	118
rs1706276^1,2	C,A,H	--	188206664(+)	`CTTTTG/TTACAA`	2	--	ds500¹		10		NA WA CSA EA	373
rs189833613^1,2		--	188206690(+)	`CAAATA/GTTTAT`	2	--	ut3¹		0	--	--	--	--
rs181290676^1,2		--	188206814(+)	`GATACA/CTGCCA`	2	--	ut3¹		0	--	--	--	--
rs185155466^1,2		--	188206933(+)	`CAGAAC/TGTAAA`	2	--	ut3¹		0	--	--	--	--
rs1728690^1,2	C,F,H	--	188206953(+)	`TTTATG/AGCTGA`	2	--	ut3¹		11		MN NA WA CSA EA	559
rs148650478^1,2		--	188207059(+)	`GCGTGC/TCTCTA`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CALCRL (188207846 - 188313187 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for CALCRL
2 CNVs: 50360 4322
5 Indels: 26514 42512 45917 40398 61870

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CALCRL for disorders           About GeneDecksing

OMIM gene information: 114190    OMIM disorders: --

20/29 diseases for CALCRL (see all 29):    About MalaCards

angle-closure glaucoma primary angle-closure glaucoma thyroiditis pulpitis

glaucoma hellp syndrome essential hypertension myocardial infarction

migraine pheochromocytoma rheumatoid arthritis glioblastoma

pancreatic cancer osteosarcoma sepsis leiomyoma

pertussis hypertension gingivitis pancreatitis

2 diseases from the University of Copenhagen DISEASES database for CALCRL:

Migraine Primary angle-closure glaucoma

10/13 Novoseek disease relationships for CALCRL gene (see all 13) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pheochromocytoma	46.5	4	17102095 (2), 16178438 (1)
migraine	39.5	6	17508187 (2), 19328288 (1)
glioblastoma	17.1	2	11943713 (1)
glioma	9.82	9	14747444 (4), 16719406 (2), 11943713 (1)
pancreatic cancer	9.09	5	17290391 (3), 17363587 (1)
glioblastoma multiforme	7.41	1	16719406 (1)
osteosarcoma	3.93	1	9350848 (1)
preeclampsia	1.48	7	19441274 (2), 11905404 (1), 15623815 (1)
heart failure	0.319	4	15300632 (1)
ischemia	0	1	12824306 (1)

Genetic Association Database (GAD): CALCRL
Human Genome Epidemiology (HuGE) Navigator: CALCRL (7 documents)

Export disorders for CALCRL gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CALCRL gene, integrated from 9 sources (see all 239):
(articles sorted by number of sources associating them with CALCRL)

Utopia: connect your pdf to the dynamic
world of online information

A cDNA encoding the calcitonin gene-related peptide type 1 receptor. (PubMed id 8626685)^{1, 2, 3} Aiyar N.... Li Y. (1996)
A human orphan calcitonin receptor-like structure. (PubMed id 7818539)^{1, 2, 3} Fluehmann B.... Born W. (1995)
Association study of calcitonin-receptor-like receptor gene in essential hypertension. (PubMed id 15797661)^{1, 4, 9} Sano M....Kokubun S. (2005)
Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding. (PubMed id 22102369)^{1, 2} Kusano S.... Yokoyama S. (2012)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
Glycosylation of human CRLR at Asn123 is required for ligand binding and signaling. (PubMed id 11389975)^{1, 9} Kamitani S. and Sakata T. (2001)
Receptor activity modifying proteins interaction with human and porcine calcitonin receptor-like receptor (CRLR) in HEK-293 cells. (PubMed id 11693189)^{1, 9} Aiyar N....Nambi P. (2001)
Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2. (PubMed id 20074556)^{1, 9} Kuwasako K....Kato J. (2010)
Protein-protein interaction and not glycosylation determines the binding selectivity of heterodimers between the calcitonin receptor-like receptor and the receptor activity-modifying proteins. (PubMed id 11387328)^{1, 9} Hilairet S....Bouvier M. (2001)
Visualization of the calcitonin receptor-like receptor and its receptor activity-modifying proteins during internalization and recycling. (PubMed id 10882736)^{1, 9} Kuwasako K....Sakata T. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10203	HGNC: 16709	AceView: CALCRL	Ensembl:ENSG00000064989	euGenes: HUgn10203
ECgene: CALCRL	Kegg: 10203	H-InvDB: CALCRL

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CALCRL	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CALCRL gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CALCRL gene:
Search GeneIP for patents involving CALCRL

GeneCards and IP:
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calcitonin receptor-like

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CALCRL Gene

calcitonin receptor-like

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