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Aliases for CALCRL Gene

Aliases for CALCRL Gene

  • Calcitonin Receptor Like Receptor 2 3 5
  • Calcitonin Receptor-Like Receptor 3 4
  • Calcitonin Receptor-Like 2 3
  • CGRP Type 1 Receptor 3 4
  • CGRPR 3 4
  • Calcitonin Gene-Related Peptide Type 1 Receptor 3
  • CRLR 3

External Ids for CALCRL Gene

Previous GeneCards Identifiers for CALCRL Gene

  • GC02M186419
  • GC02M186892
  • GC02M188171
  • GC02M188412
  • GC02M188035
  • GC02M187918
  • GC02M180067

Summaries for CALCRL Gene

GeneCards Summary for CALCRL Gene

CALCRL (Calcitonin Receptor Like Receptor) is a Protein Coding gene. Diseases associated with CALCRL include Migraine With Or Without Aura 1 and Pheochromocytoma. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and protein transporter activity. An important paralog of this gene is CALCR.

UniProtKB/Swiss-Prot for CALCRL Gene

  • Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Tocris Summary for CALCRL Gene

  • Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys.

Gene Wiki entry for CALCRL Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALCRL Gene

Genomics for CALCRL Gene

Regulatory Elements for CALCRL Gene

Enhancers for CALCRL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CALCRL on UCSC Golden Path with GeneCards custom track

Promoters for CALCRL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CALCRL Gene

Chromosome:
2
Start:
187,341,963 bp from pter
End:
187,448,460 bp from pter
Size:
106,498 bases
Orientation:
Minus strand

Genomic View for CALCRL Gene

Genes around CALCRL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALCRL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALCRL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALCRL Gene

Proteins for CALCRL Gene

  • Protein details for CALCRL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16602-CALRL_HUMAN
    Recommended name:
    Calcitonin gene-related peptide type 1 receptor
    Protein Accession:
    Q16602
    Secondary Accessions:
    • A8K6G5
    • A8KAD3
    • Q53S02
    • Q53TS5

    Protein attributes for CALCRL Gene

    Size:
    461 amino acids
    Molecular mass:
    52929 Da
    Quaternary structure:
    • Heterodimer of CALCRL and RAMP3 (By similarity). Heterodimer of CALCRL and RAMP1 or CALCRL and RAMP2.
    SequenceCaution:
    • Sequence=BAF84319.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CALCRL Gene

neXtProt entry for CALCRL Gene

Post-translational modifications for CALCRL Gene

  • Glycosylation at Asn 66, Asn 118, and Asn 123
  • Modification sites at PhosphoSitePlus

Other Protein References for CALCRL Gene

No data available for DME Specific Peptides for CALCRL Gene

Domains & Families for CALCRL Gene

Gene Families for CALCRL Gene

Suggested Antigen Peptide Sequences for CALCRL Gene

Graphical View of Domain Structure for InterPro Entry

Q16602

UniProtKB/Swiss-Prot:

CALRL_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family.
Family:
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with CALCRL: view

Function for CALCRL Gene

Molecular function for CALCRL Gene

UniProtKB/Swiss-Prot Function:
Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Gene Ontology (GO) - Molecular Function for CALCRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001605 adrenomedullin receptor activity IDA 22102369
GO:0001635 calcitonin gene-related peptide receptor activity IEA --
GO:0004930 G-protein coupled receptor activity TAS 7818539
GO:0004948 calcitonin receptor activity IEA --
GO:0005515 protein binding IPI 9620797
genes like me logo Genes that share ontologies with CALCRL: view
genes like me logo Genes that share phenotypes with CALCRL: view

Animal Models for CALCRL Gene

MGI Knock Outs for CALCRL:

Animal Model Products

CRISPR Products

miRNA for CALCRL Gene

miRTarBase miRNAs that target CALCRL

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CALCRL Gene

Localization for CALCRL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CALCRL Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CALCRL Gene COMPARTMENTS Subcellular localization image for CALCRL gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
lysosome 5
plasma membrane 5
vacuole 5
extracellular 1

Gene Ontology (GO) - Cellular Components for CALCRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA 10882736
GO:0005768 endosome IDA 10882736
GO:0005783 endoplasmic reticulum IDA 10882736
GO:0005886 plasma membrane IDA,TAS --
GO:0005887 integral component of plasma membrane TAS 7818539
genes like me logo Genes that share ontologies with CALCRL: view

Pathways & Interactions for CALCRL Gene

genes like me logo Genes that share pathways with CALCRL: view

Gene Ontology (GO) - Biological Process for CALCRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IDA 20596610
GO:0006171 cAMP biosynthetic process IDA 20074556
GO:0006816 calcium ion transport IDA 10882736
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 7818539
genes like me logo Genes that share ontologies with CALCRL: view

No data available for SIGNOR curated interactions for CALCRL Gene

Drugs & Compounds for CALCRL Gene

(10) Drugs for CALCRL Gene - From: ApexBio, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MK-3207 HCl Pharma 0 0
CGRP Pharma 0
AC 187 Pharma Amylin receptor antagonist, Potent and selective, Potent and selective amylin receptor antagonist 0
CGRP (rat) Pharma Potent vasodilator 0
CGRP 8-37 (rat) Pharma CGRP1 receptor antagonist 0

(5) Additional Compounds for CALCRL Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha-CGRP (human)
90954-53-3
BIBN 4096
204697-65-4

(5) Tocris Compounds for CALCRL Gene

Compound Action Cas Number
AC 187 Potent and selective amylin receptor antagonist 151804-77-2
alpha-CGRP (human) CGRP receptor agonist 90954-53-3
BIBN 4096 Potent and selective CGRP receptor antagonist 204697-65-4
CGRP (rat) Potent vasodilator 83651-90-5
CGRP 8-37 (rat) CGRP1 receptor antagonist 129121-73-9

(1) ApexBio Compounds for CALCRL Gene

Compound Action Cas Number
MK-3207 HCl 0 957116-20-0
genes like me logo Genes that share compounds with CALCRL: view

Transcripts for CALCRL Gene

Unigene Clusters for CALCRL Gene

Calcitonin receptor-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CALCRL Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - -
SP2: - - -
SP3: - - - - - - - -
SP4: -
SP5: - - - - -
SP6: - - - - - - -
SP7: - -
SP8: - - - - - -
SP9: - -
SP10:
SP11: - - - -

Relevant External Links for CALCRL Gene

GeneLoc Exon Structure for
CALCRL
ECgene alternative splicing isoforms for
CALCRL

Expression for CALCRL Gene

mRNA expression in normal human tissues for CALCRL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CALCRL Gene

This gene is overexpressed in Lung (x6.1) and Adipose - Visceral (Omentum) (x4.4).

Protein differential expression in normal tissues from HIPED for CALCRL Gene

This gene is overexpressed in Lung (38.1) and Spinal cord (18.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CALCRL Gene



Protein tissue co-expression partners for CALCRL Gene

NURSA nuclear receptor signaling pathways regulating expression of CALCRL Gene:

CALCRL

SOURCE GeneReport for Unigene cluster for CALCRL Gene:

Hs.470882

mRNA Expression by UniProt/SwissProt for CALCRL Gene:

Q16602-CALRL_HUMAN
Tissue specificity: Predominantly expressed in the lung and heart.
genes like me logo Genes that share expression patterns with CALCRL: view

Primer Products

Orthologs for CALCRL Gene

This gene was present in the common ancestor of animals.

Orthologs for CALCRL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CALCRL 34
  • 90.53 (n)
  • 92.41 (a)
CALCRL 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CALCRL 34
  • 90.09 (n)
  • 93.71 (a)
CALCRL 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Calcrl 34
  • 85.36 (n)
  • 90.22 (a)
Calcrl 16
Calcrl 35
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CALCRL 34
  • 99.86 (n)
  • 100 (a)
CALCRL 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Calcrl 34
  • 86.23 (n)
  • 90.87 (a)
oppossum
(Monodelphis domestica)
Mammalia CALCRL 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CALCRL 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves CALCRL 34
  • 77.2 (n)
  • 83.3 (a)
CALCRL 35
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CALCRL 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia calcrl 34
  • 74.55 (n)
  • 84.09 (a)
Str.12334 34
African clawed frog
(Xenopus laevis)
Amphibia calcrl-prov 34
zebrafish
(Danio rerio)
Actinopterygii calcrla 34
  • 69.32 (n)
  • 73.67 (a)
calcrla 35
  • 70 (a)
OneToMany
calcrlb 35
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta EG:BACR25B3.3 36
  • 28 (a)
Dh31-R1 34
  • 50.28 (n)
  • 43.79 (a)
Dh31-R1 35
  • 34 (a)
ManyToMany
hec 35
  • 27 (a)
ManyToMany
Pdfr 35
  • 19 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GPRCAL1 34
  • 49.32 (n)
  • 44.8 (a)
worm
(Caenorhabditis elegans)
Secernentea pdfr-1 35
  • 21 (a)
OneToMany
Species where no ortholog for CALCRL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CALCRL Gene

ENSEMBL:
Gene Tree for CALCRL (if available)
TreeFam:
Gene Tree for CALCRL (if available)

Paralogs for CALCRL Gene

(9) SIMAP similar genes for CALCRL Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CALCRL: view

Variants for CALCRL Gene

Sequence variations from dbSNP and Humsavar for CALCRL Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs13391909 - 187,385,548(+) ACCAT(A/T)AAAAA reference, missense
rs34010553 - 187,359,233(-) TGCTA(G/T)AAGCT reference, missense
rs698577 - 187,385,574(+) AAAAT(A/G/T)CAGGG reference, missense
rs1056599 -- 187,345,791(-) TTATT(C/G/T)ACCCC utr-variant-3-prime
rs1102486 -- 187,356,754(+) cccat(C/G)tgaca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CALCRL Gene

Variant ID Type Subtype PubMed ID
dgv2113n106 CNV deletion 24896259
dgv4132n100 CNV loss 25217958
esv1009899 CNV deletion 20482838
esv1045156 CNV deletion 17803354
esv2249015 CNV deletion 18987734
esv2721246 CNV deletion 23290073
esv2840124 CNV deletion 24192839
esv3033 CNV loss 18987735
esv3560691 CNV deletion 23714750
esv3593690 CNV loss 21293372
esv6916 CNV loss 19470904
esv992040 CNV deletion 20482838
nsv1011800 CNV loss 25217958
nsv1073001 CNV deletion 25765185
nsv1160891 CNV duplication 26073780
nsv459989 CNV loss 19166990
nsv474198 CNV novel sequence insertion 20440878
nsv517687 CNV loss 19592680
nsv584036 CNV loss 21841781
nsv584037 CNV loss 21841781
nsv834487 CNV gain 17160897
nsv834488 CNV gain+loss 17160897
nsv954711 CNV deletion 24416366
nsv979157 CNV duplication 23825009

Variation tolerance for CALCRL Gene

Residual Variation Intolerance Score: 35.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CALCRL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CALCRL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALCRL Gene

Disorders for CALCRL Gene

MalaCards: The human disease database

(3) MalaCards diseases for CALCRL Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
migraine with or without aura 1
  • migraine
pheochromocytoma
  • pheochromocytoma, modifier of
gastroesophageal junction adenocarcinoma
  • adenocarcinoma of cardioesophageal junction
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CALCRL

Genetic Association Database (GAD)
CALCRL
Human Genome Epidemiology (HuGE) Navigator
CALCRL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CALCRL
genes like me logo Genes that share disorders with CALCRL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CALCRL Gene

Publications for CALCRL Gene

  1. Investigation of the association between CALCRL polymorphisms and primary angle closure glaucoma. (PMID: 19898635) Cao D. … Mao Z. (Mol. Vis. 2009) 3 22 46 65
  2. Lack of linkage and association of adrenomedullin and its receptor genes in French Caucasian rheumatoid arthritis trio families. (PMID: 19210874) Michou L. … LiotAc F. (Clin. Exp. Rheumatol. 2008) 3 22 46 65
  3. Association study of calcitonin-receptor-like receptor gene in essential hypertension. (PMID: 15797661) Sano M. … Kokubun S. (Am. J. Hypertens. 2005) 3 22 46 65
  4. A cDNA encoding the calcitonin gene-related peptide type 1 receptor. (PMID: 8626685) Aiyar N. … Li Y. (J. Biol. Chem. 1996) 2 3 4 65
  5. A human orphan calcitonin receptor-like structure. (PMID: 7818539) Fluehmann B. … Born W. (Biochem. Biophys. Res. Commun. 1995) 2 3 4 65

Products for CALCRL Gene

Sources for CALCRL Gene

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