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CALCRL Gene

protein-coding   GIFtS: 65
GCID: GC02M188171

Calcitonin Receptor-Like

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calcitonin Receptor-Like1 2
CGRPR2 3 5
Calcitonin Receptor-Like Receptor2 3
CGRP Type 1 Receptor2 3
CRLR2 5
Calcitonin Gene-Related Peptide Type 1 Receptor2

External Ids:    HGNC: 167091   Entrez Gene: 102032   Ensembl: ENSG000000649897   OMIM: 1141905   UniProtKB: Q166023   

Export aliases for CALCRL gene to outside databases

Previous GC identifers: GC02M186419 GC02M186892 GC02M188412 GC02M188035 GC02M187918 GC02M180067


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CALCRL Gene:
CALCRL (calcitonin receptor-like) is a protein-coding gene. Diseases associated with CALCRL include pulpitis, and primary angle-closure glaucoma. GO annotations related to this gene include G-protein coupled receptor activity and calcitonin receptor activity. An important paralog of this gene is GLP1R.

UniProtKB/Swiss-Prot: CALRL_HUMAN, Q16602
Function: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin
together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this
receptor is mediated by G proteins which activate adenylyl cyclase

summary for CALCRL Gene:
Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight
subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The receptors have a wide biological distribution;
high concentrations are found in the brain, lung, liver, heart and spleen with lower expression levels
present in the testes, gastrointestinal tract and thyroid. The main function of CT receptors is to inhibit
bone reabsorption and enhance calcium excretion by the kidneys. AMY receptors are heterodimers of the CT
receptor and receptor activating modifying proteins (RAMP) 1-3, which have been implicated in type II
diabetes pathology. The CALCRL receptor alone is non-functioning, but forms heterodimers with RAMPs to form
the CGRP (CALCRL with RAMP1), AM1 (CALCRL with RAMP2) and AM2 (CALCRL with RAMP3) receptors. Their main
function is inducing vasodilation, which causes hypotension.

Gene Wiki entry for CALCRL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CALCRL gene promoter:
         SRF   STAT1   SRF (504 AA)   ATF-2   GATA-1   CREB   POU2F1   deltaCREB   POU2F1a   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCALCRL promoter sequence
   Search Chromatin IP Primers for CALCRL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CALCRL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32.1   Ensembl cytogenetic band:  2q32.1   HGNC cytogenetic band: 2q21.1-q21.3

CALCRL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CALCRL gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M188171:  view genomic region     (about GC identifiers)

Start:
188,207,846 bp from pter      End:
188,313,187 bp from pter
Size:
105,342 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CALRL_HUMAN, Q16602 (See protein sequence)
Recommended Name: Calcitonin gene-related peptide type 1 receptor precursor  
Size: 461 amino acids; 52929 Da
Subunit: Heterodimer of CALCRL and RAMP3 (By similarity). Heterodimer of CALCRL and RAMP1 or CALCRL and RAMP2
Sequence caution: Sequence=BAF84319.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
4 PDB 3D structures from and Proteopedia for CALCRL:
3AQF (3D)        3N7P (3D)        3N7R (3D)        3N7S (3D)    
Secondary accessions: A8K6G5 A8KAD3 Q53S02 Q53TS5

Explore the universe of human proteins at neXtProt for CALCRL: NX_Q16602

Explore proteomics data for CALCRL at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn66, Asn118, Asn123
  • Modification sites at PhosphoSitePlus

  • See CALCRL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001258680.1  NP_005786.1  

    ENSEMBL proteins: 
     ENSP00000376177   ENSP00000386972   ENSP00000387190   ENSP00000415626   ENSP00000386599  
    Reactome Protein details: Q16602

    CALCRL Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CALCRL Protein
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    Browse OriGene Protein Over-expression Lysates
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    OriGene Custom Protein Services for CALCRL
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    Novus Biologicals CALCRL Proteins
    Novus Biologicals CALCRL Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CALCRL

    CALCRL Antibody Products:

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    Novus Biologicals CALCRL Antibodies
    Abcam antibodies for CALCRL
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    ThermoFisher Antibodies for CALCRL
    LSBio Antibodies in human, mouse, rat for CALCRL

    CALCRL Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. CLIAs for CALCRL


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CALCR: GPCR / Class B : Calcitonin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: calcitonin receptor-like receptor
    Calcitonin receptors

    Selected InterPro protein domains (see all 6):
     IPR001879 GPCR_2_extracellular_dom
     IPR003287 GCPR_2_calcitonin_rcpt_fam
     IPR000832 GPCR_2_secretin-like
     IPR003289 GPCR_2_CGRP1_rcpt
     IPR017983 GPCR_2_secretin-like_CS

    Graphical View of Domain Structure for InterPro Entry Q16602

    ProtoNet protein and cluster: Q16602

    3 Blocks protein domains:
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB003287 Calcitonin receptor family signature
    IPB003289 Calcitonin gene-related peptide type 1 receptor signature


    UniProtKB/Swiss-Prot: CALRL_HUMAN, Q16602
    Similarity: Belongs to the G-protein coupled receptor 2 family


    CALCRL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CALRL_HUMAN, Q16602
    Function: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin
    together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this
    receptor is mediated by G proteins which activate adenylyl cyclase

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001605adrenomedullin receptor activity IDA--
    GO:0001635calcitonin gene-related polypeptide receptor activity IEA--
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity TAS7818539
    GO:0004948calcitonin receptor activity IEA--
         
    CALCRL for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Calcrl):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  hematopoietic system 
     homeostasis/metabolism  immune system  integument  mortality/aging  muscle 
     reproductive system 

    CALCRL for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Calcrltm1Kmca for CALCRL

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CALCRL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CALCRL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CALCRL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CALCRL

    miRNA
    Products:
        
    miRTarBase miRNAs that target CALCRL:
    hsa-mir-124-3p (MIRT022193)

    Block miRNA regulation of human, mouse, rat CALCRL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CALCRL (see all 27):
    hsa-miR-361-5p hsa-miR-448 hsa-miR-513c hsa-miR-371-5p hsa-miR-500a hsa-miR-29b-1* hsa-miR-373* hsa-miR-511
    SwitchGear 3'UTR luciferase reporter plasmidCALCRL 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CALCRL
    Predesigned siRNA for gene silencing in human, mouse, rat CALCRL

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CALCRL

    Clone
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    OriGene clones in human, mouse for CALCRL (see all 6)
    OriGene ORF clones in mouse, rat for CALCRL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CALCRL (NM_005795)
    Sino Biological Human cDNA Clone for CALCRL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALCRL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCRL

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALCRL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CALRL_HUMAN, Q16602: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    endosome5
    lysosome5
    plasma membrane5
    vacuole5
    extracellular2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005764lysosome IDA10882736
    GO:0005768endosome IDA10882736
    GO:0005783endoplasmic reticulum IDA10882736
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7818539

    CALCRL for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CALCRL About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3ADP signalling through P2Y purinoceptor 12
    Class B/2 (Secretin family receptors)0.36
    Calcitonin-like ligand receptors0.00
    4Oxytocin signaling pathway
    Vascular smooth muscle contraction0.32
    5GPCRs, Class B Secretin-like
    GPCRs, Class B Secretin-like

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for CALCRL
        GPCRs, Class B Secretin-like
    Endothelin


    2 Reactome Pathways for CALCRL
        Calcitonin-like ligand receptors
    G alpha (s) signalling events


    2 Kegg Pathways  (Kegg details for CALCRL):
        Neuroactive ligand-receptor interaction
    Vascular smooth muscle contraction


    CALCRL for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CALCRL: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CALCRL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for CALCRL (Q166021, 3 ENSP000003761774) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALCAP068811, ENSP000003317464EBI-962878,EBI-962928 I2D: score=1 STRING: ENSP00000331746
    ADMP353183, ENSP000002781754I2D: score=1 STRING: ENSP00000278175
    RAMP2O608953, ENSP000002537964I2D: score=1 STRING: ENSP00000253796
    RAMP1O608943, ENSP000002546614I2D: score=3 STRING: ENSP00000254661
    RAMP3O608963, ENSP000002422494I2D: score=2 STRING: ENSP00000242249
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IDA--
    GO:0006171cAMP biosynthetic process IDA--
    GO:0006816calcium ion transport IDA10882736
    GO:0006937regulation of muscle contraction IEA--
    GO:0007166cell surface receptor signaling pathway ----

    CALCRL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for CALCRL available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AC 187Potent and selective amylin receptor antagonist[151804-77-2]
    CGRP 8-37 (rat)CGRP1 receptor antagonist[129121-73-9]
    CGRP 8-37 (human)CGRP1 receptor antagonist[119911-68-1]
    BIBN 4096Potent and selective CGRP receptor antagonist[204697-65-4]
    alpha-CGRP (human)CGRP receptor agonist[90954-53-3]

    8 Novoseek inferred chemical compound relationships for CALCRL gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bibn 4096 bs 90.9 5 12183333 (3), 19914210 (1)
    cyclic amp 30.5 2 12630807 (1)
    glibenclamide 28.7 1 9428220 (1)
    adenylate 27 3 14631146 (1), 9350848 (1), 12196109 (1)
    tunicamycin 19.2 2 11389975 (2)
    nitric oxide 0 5 9516404 (1), 14717924 (1), 19441274 (1)
    potassium 0 1 9877154 (1)
    dexamethasone 0 11 10772950 (4), 15358098 (4)



    CALCRL for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CALCRL gene (2 alternative transcripts): 
    NM_001271751.1  NM_005795.5  

    Unigene Cluster for CALCRL:

    Calcitonin receptor-like
    Hs.470882  [show with all ESTs]
    Unigene Representative Sequence: NM_005795
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392370(uc002upv.4 uc010frt.3) ENST00000409998 ENST00000410068
    ENST00000447403 ENST00000410102 ENST00000474212 ENST00000485973 ENST00000461244
    ENST00000479784(uc002upw.2)
    miRNA
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    Block miRNA regulation of human, mouse, rat CALCRL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CALCRL (see all 27):
    hsa-miR-361-5p hsa-miR-448 hsa-miR-513c hsa-miR-371-5p hsa-miR-500a hsa-miR-29b-1* hsa-miR-373* hsa-miR-511
    SwitchGear 3'UTR luciferase reporter plasmidCALCRL 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CALCRL
    Predesigned siRNA for gene silencing in human, mouse, rat CALCRL
    Clone
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    OriGene clones in human, mouse for CALCRL (see all 6)
    OriGene ORF clones in mouse, rat for CALCRL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CALCRL (NM_005795)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CALCRL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CALCRL
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CALCRL
    OriGene qSTAR qPCR primer pairs in human, mouse for CALCRL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CALCRL
      QuantiTect SYBR Green Assays in human, mouse, rat CALCRL
      QuantiFast Probe-based Assays in human, mouse, rat CALCRL

    Additional mRNA sequence: 

    AK291630.1 AK292998.1 AY389506.1 L76380.1 U17473.1 

    5 DOTS entries:

    DT.210868  DT.99949950  DT.120960773  DT.120960866  DT.120960762 

    Selected AceView cDNA sequences (see all 77):

    NM_005795 AA436933 AA961493 AA885023 AY389506 AI500611 BU677790 N54728 
    AW272754 BX471114 BX646999 AI478743 BG548162 AI741128 Z28783 BX474361 
    BQ883932 AL599885 BX480040 AW090287 BQ893529 CB052425 BX509212 AA757351 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CALCRL (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                    -     -           -           -                                                                     
    SP2:                    -                 -           -                                                                     
    SP3:                    -     -     -     -           -     -     -     -                                                   
    SP4:                                      -                                                                                 
    SP5:                    -     -     -     -           -                                                                     


    ECgene alternative splicing isoforms for CALCRL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CALCRL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CALCRL Expression
    About this image


    CALCRL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Ureteric Bud Cells Ureteric Bud
             S-shaped Body
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Bone (Muscoskeletal System)
             HyStem+BMP4-induced MEL2 cells
     
     Oligodendrocytes (Nervous System)
             Oligodendrocyte progenitor cells
     
     Endothelium (Cardiovascular System)
             Human umbilical vein endothelial cells (HUVEC)
    CALCRL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CALCRL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.470882

    UniProtKB/Swiss-Prot: CALRL_HUMAN, Q16602
    Tissue specificity: Predominantly expressed in the lung and heart

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CALCRL: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CALCRL
    OriGene qSTAR qPCR primer pairs in human, mouse for CALCRL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CALCRL
    QuantiTect SYBR Green Assays in human, mouse, rat CALCRL
    QuantiFast Probe-based Assays in human, mouse, rat CALCRL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CALCRL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CALCRL gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Calcrl1 , 5 calcitonin receptor-like1, 5 85.36(n)1
    90.22(a)1
      2 (49.38 cM)5
    545981  NM_018782.21  NP_061252.21 
     843306265 
    chicken
    (Gallus gallus)
    Aves CALCRL1 calcitonin receptor-like 77.2(n)
    83.3(a)
      423990  NM_001163650.1  NP_001157122.1 
    lizard
    (Anolis carolinensis)
    Reptilia CALCRL6
    calcitonin receptor-like
    73(a)
    1 ↔ 1
    GL343290.1(219300-249259)
    African clawed frog
    (Xenopus laevis)
    Amphibia calcrl-prov2 calcitonin receptor-like 79.64(n)    BC044269.1 
    zebrafish
    (Danio rerio)
    Actinopterygii calcrla1 calcitonin receptor-like a 69.32(n)
    73.67(a)
      445508  NM_001004010.1  NP_001004010.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta EG:BACR25B3.33
    Dh31-R11
    G-protein coupled receptor protein
    signaling pathway more3
    Diuretic hormone 31 receptor 11
    28(a)3
    50.28(n)1
    43.79(a)1
      3A63
    364751  NM_001274021.11  NP_001260950.11 
    worm
    (Caenorhabditis elegans)
    Secernentea pdfr-16
    Protein PDFR-1, isoform c (pdfr-1) mRNA, complete ...
    21(a)
    1 → many
    III(6632841-6652083) WBGene00015735


    ENSEMBL Gene Tree for CALCRL (if available)
    TreeFam Gene Tree for CALCRL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CALCRL gene
    GLP1R2  GHRHR2  GCGR2  CALCR2  PTH1R2  CRHR22  VIPR12  CRHR12  
    PTH2R2  SCTR2  ADCYAP1R12  GLP2R2  VIPR22  GIPR2  
    9 SIMAP similar genes for CALCRL using alignment to 4 protein entries:     CALRL_HUMAN (see all proteins):
    CALCR    VIPR1    CRHR2    SCTR    GCGR    GIPR
    GLP1R    PTH1R    ADCYAP1R1

    CALCRL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CALCRL (see all 1793)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1158283581,2
    F--188206448(+) TACACA/GTGGCC 2 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1162192691,2
    F--188206509(+) AGGTAC/TCATTT 2 -- ds50011Minor allele frequency- T:0.02WA 118
    rs17062761,2
    C,A,H--188206664(+) cttttG/Ttacaa 2 -- ds500110Minor allele frequency- T:0.29NA WA CSA EA 373
    rs1898336131,2
    --188206690(+) CAAATA/GTTTAT 2 -- ut310--------
    rs1812906761,2
    --188206814(+) GATACA/CTGCCA 2 -- ut310--------
    rs1851554661,2
    --188206933(+) CAGAAC/TGTAAA 2 -- ut310--------
    rs17286901,2
    C,F,H--188206953(+) TTTATG/AGCTGA 2 -- ut3111Minor allele frequency- A:0.35MN NA WA CSA EA 559
    rs1486504781,2
    --188207059(+) GCGTGC/TCTCTA 2 -- ut310--------
    rs15282331,2
    C,F,O,A,H--188207245(+) CAACAG/ATAGGC 2 -- ut3119Minor allele frequency- A:0.35MN NS EA NA WA CSA 1339
    rs1411464551,2
    --188207246(+) AACAAC/TAGGCC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for CALCRL (188207846 - 188313187 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CALCRL (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1009899CNV Deletion20482838
    esv1045156CNV Deletion17803354
    esv2721246CNV Deletion23290073
    esv992040CNV Deletion20482838
    esv2249015CNV Deletion18987734
    esv3033CNV Deletion18987735
    dgv4396n71CNV Loss21882294
    dgv4394n71CNV Loss21882294
    dgv4395n71CNV Loss21882294
    dgv4393n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CALCRL
    DNA2.0 Custom Variant and Variant Library Synthesis for CALCRL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 114190    OMIM disorders: --

    Selected diseases for CALCRL (see all 30):    
    About MalaCards
    pulpitis    primary angle-closure glaucoma    hellp syndrome    asperger syndrome
    pheochromocytoma    migraine    glioblastoma multiforme    sepsis
    thyroiditis    osteosarcoma    glaucoma    hyperparathyroidism
    leiomyoma    pertussis    gingivitis    essential hypertension
    pancreatic cancer    ischemia    hypertension    infertility

    2 diseases from the University of Copenhagen DISEASES database for CALCRL:
    Migraine     Primary angle-closure glaucoma

    CALCRL for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CALCRL gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pheochromocytoma 46.5 4 17102095 (2), 16178438 (1)
    migraine 39.5 6 17508187 (2), 19328288 (1)
    glioblastoma 17.1 2 11943713 (1)
    glioma 9.82 9 14747444 (4), 16719406 (2), 11943713 (1)
    pancreatic cancer 9.09 5 17290391 (3), 17363587 (1)
    glioblastoma multiforme 7.41 1 16719406 (1)
    osteosarcoma 3.93 1 9350848 (1)
    preeclampsia 1.48 7 19441274 (2), 11905404 (1), 15623815 (1)
    heart failure 0.319 4 15300632 (1)
    ischemia 0 1 12824306 (1)

    Genetic Association Database (GAD): CALCRL
    Human Genome Epidemiology (HuGE) Navigator: CALCRL (7 documents)

    Export disorders for CALCRL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CALCRL gene, integrated from 10 sources (see all 240):
    (articles sorted by number of sources associating them with CALCRL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A cDNA encoding the calcitonin gene-related peptide type 1 receptor. (PubMed id 8626685)1, 2, 3 Aiyar N.... Li Y. (J. Biol. Chem. 1996)
    2. A human orphan calcitonin receptor-like structure. (PubMed id 7818539)1, 2, 3 Fluehmann B.... Born W. (Biochem. Biophys. Res. Commun. 1995)
    3. Lack of linkage and association of adrenomedullin and its receptor genes in French Caucasian rheumatoid arthritis trio families. (PubMed id 19210874)1, 4, 9 Michou L....LiotAc F. (Clin. Exp. Rheumatol. 2008)
    4. Investigation of the association between CALCRL polymorphisms and primary angle closure glaucoma. (PubMed id 19898635)1, 4, 9 Cao D....Mao Z. (Mol. Vis. 2009)
    5. Association study of calcitonin-receptor-like receptor gene in essential hypertension. (PubMed id 15797661)1, 4, 9 Sano M....Kokubun S. (Am. J. Hypertens. 2005)
    6. Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding. (PubMed id 22102369)1, 2 Kusano S.... Yokoyama S. (Protein Sci. 2012)
    7. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    9. Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. (PubMed id 19598235)1, 4 Chakrabarti B....Baron-Cohen S. (Autism Res 2009)
    10. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10203 HGNC: 16709 AceView: CALCRL Ensembl:ENSG00000064989 euGenes: HUgn10203
    ECgene: CALCRL Kegg: 10203 H-InvDB: CALCRL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CALCRL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CALCRL gene:
    Search GeneIP for patents involving CALCRL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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